BTRC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. The encoded protein mediates degradation of CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), targeting it for degradation and thus activating nuclear factor kappa-B. Alternatively spliced transcript variants have been described. A related pseudogene exists in chromosome 6. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.02134997
2positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.58844162
3synaptic vesicle docking involved in exocytosis (GO:0016081)5.16067897
4synaptic vesicle maturation (GO:0016188)5.13078545
5synaptic vesicle exocytosis (GO:0016079)5.09058325
6regulation of synaptic vesicle exocytosis (GO:2000300)4.76436149
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.58139224
8regulation of synaptic vesicle transport (GO:1902803)4.49226501
9locomotory exploration behavior (GO:0035641)4.47037338
10positive regulation of synapse maturation (GO:0090129)4.44091021
11glutamate secretion (GO:0014047)4.43130132
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.99692531
13neuromuscular process controlling posture (GO:0050884)3.98612988
14protein localization to synapse (GO:0035418)3.94481356
15vocalization behavior (GO:0071625)3.91744672
16neurotransmitter secretion (GO:0007269)3.86865716
17regulation of glutamate receptor signaling pathway (GO:1900449)3.76847277
18regulation of neuronal synaptic plasticity (GO:0048168)3.70330999
19synaptic transmission, glutamatergic (GO:0035249)3.63614209
20regulation of synapse structural plasticity (GO:0051823)3.61703826
21ionotropic glutamate receptor signaling pathway (GO:0035235)3.52415424
22regulation of long-term neuronal synaptic plasticity (GO:0048169)3.48241154
23neuronal action potential propagation (GO:0019227)3.47964465
24postsynaptic membrane organization (GO:0001941)3.47086913
25neuron cell-cell adhesion (GO:0007158)3.42114893
26exploration behavior (GO:0035640)3.41163058
27positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.40979560
28regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.39185636
29neuron-neuron synaptic transmission (GO:0007270)3.36633472
30regulation of synapse maturation (GO:0090128)3.35643400
31positive regulation of membrane potential (GO:0045838)3.32620558
32membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.28826609
33long-term memory (GO:0007616)3.27163882
34L-amino acid import (GO:0043092)3.26754033
35amino acid import (GO:0043090)3.26473604
36neurotransmitter-gated ion channel clustering (GO:0072578)3.22677091
37regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.20761763
38glutamate receptor signaling pathway (GO:0007215)3.20621291
39neurotransmitter transport (GO:0006836)3.18585898
40presynaptic membrane assembly (GO:0097105)3.18543157
41synaptic vesicle endocytosis (GO:0048488)3.15195232
42dendritic spine morphogenesis (GO:0060997)3.09431421
43presynaptic membrane organization (GO:0097090)3.06429082
44gamma-aminobutyric acid transport (GO:0015812)3.05679328
45regulation of dendritic spine morphogenesis (GO:0061001)3.03787629
46regulation of synaptic plasticity (GO:0048167)3.01965058
47positive regulation of synaptic transmission, GABAergic (GO:0032230)3.01653322
48regulation of neurotransmitter secretion (GO:0046928)3.01119911
49neuronal ion channel clustering (GO:0045161)2.99927308
50cell communication by electrical coupling (GO:0010644)2.99209552
51cellular potassium ion homeostasis (GO:0030007)2.94872577
52neuromuscular process controlling balance (GO:0050885)2.94577099
53positive regulation of neurotransmitter transport (GO:0051590)2.93194205
54membrane depolarization during action potential (GO:0086010)2.92785039
55layer formation in cerebral cortex (GO:0021819)2.91783190
56regulation of excitatory postsynaptic membrane potential (GO:0060079)2.90695565
57cerebellar Purkinje cell differentiation (GO:0021702)2.89139560
58response to pheromone (GO:0019236)2.88879392
59innervation (GO:0060384)2.88525552
60regulation of neurotransmitter transport (GO:0051588)2.86275007
61regulation of neurotransmitter levels (GO:0001505)2.85848586
62cell migration in hindbrain (GO:0021535)2.85462011
63cell communication involved in cardiac conduction (GO:0086065)2.85073398
64cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.84994661
65regulation of postsynaptic membrane potential (GO:0060078)2.84524873
66phosphorelay signal transduction system (GO:0000160)2.78742415
67neuron recognition (GO:0008038)2.78294312
68positive regulation of neurotransmitter secretion (GO:0001956)2.77530075
69vesicle transport along microtubule (GO:0047496)2.77484571
70prepulse inhibition (GO:0060134)2.77205560
71striatum development (GO:0021756)2.76929732
72auditory behavior (GO:0031223)2.75839935
73behavioral fear response (GO:0001662)2.74851499
74behavioral defense response (GO:0002209)2.74851499
75negative regulation of synaptic transmission, GABAergic (GO:0032229)2.73755028
76axonal fasciculation (GO:0007413)2.72781053
77regulation of calcium ion-dependent exocytosis (GO:0017158)2.71567423
78sodium ion export (GO:0071436)2.71130836
79G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.70805066
80synaptic vesicle transport (GO:0048489)2.70276513
81establishment of synaptic vesicle localization (GO:0097480)2.70276513
82neuromuscular process (GO:0050905)2.70211876
83dendrite morphogenesis (GO:0048813)2.68453857
84regulation of DNA methylation (GO:0044030)2.68186147
85regulation of vesicle fusion (GO:0031338)2.67841603
86regulation of synaptic transmission, glutamatergic (GO:0051966)2.67371431
87dendritic spine organization (GO:0097061)2.65773495
88negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.65685953
89positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.65523830
90negative regulation of dendrite morphogenesis (GO:0050774)2.64499599
91positive regulation of dendritic spine development (GO:0060999)2.64465233
92regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.64038646
93activation of protein kinase A activity (GO:0034199)2.63692157
94cerebellar granule cell differentiation (GO:0021707)2.62123248
95negative regulation of potassium ion transmembrane transport (GO:1901380)2.61850743
96long-term synaptic potentiation (GO:0060291)2.61084657
97membrane hyperpolarization (GO:0060081)2.60941449
98pyrimidine nucleobase catabolic process (GO:0006208)2.60742681
99organelle transport along microtubule (GO:0072384)2.60594151
100cerebral cortex radially oriented cell migration (GO:0021799)2.59182907
101calcium ion-dependent exocytosis (GO:0017156)2.58429576
102proline transport (GO:0015824)2.58125309
103regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.56626972
104regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.56626972
105response to auditory stimulus (GO:0010996)2.56457137
106regulation of dendritic spine development (GO:0060998)2.55272283
107startle response (GO:0001964)2.55131130
108transmission of nerve impulse (GO:0019226)2.54255505
109GMP metabolic process (GO:0046037)2.53795777
110establishment of mitochondrion localization (GO:0051654)2.53583021
111membrane depolarization (GO:0051899)2.53077398
112righting reflex (GO:0060013)2.52432084
113negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.52207950
114synaptic transmission (GO:0007268)2.51979540
115fear response (GO:0042596)2.51674843
116synapse assembly (GO:0007416)2.51049275
117positive regulation of dendritic spine morphogenesis (GO:0061003)2.51023587
118establishment of vesicle localization (GO:0051650)2.49987703
119negative regulation of microtubule depolymerization (GO:0007026)2.49866311
120cerebellar Purkinje cell layer development (GO:0021680)2.48882331
121regulation of synaptic transmission (GO:0050804)2.48183830
122chemosensory behavior (GO:0007635)2.47996575
123positive regulation of synaptic transmission (GO:0050806)2.47731961
124cytoskeletal anchoring at plasma membrane (GO:0007016)2.46946170
125regulation of synaptic transmission, dopaminergic (GO:0032225)2.44162328
126apical protein localization (GO:0045176)2.43905467
127regulation of respiratory system process (GO:0044065)2.43736568
128cullin deneddylation (GO:0010388)2.43609486
129long-chain fatty acid biosynthetic process (GO:0042759)2.43425243
130adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.43384282
131neuron projection extension (GO:1990138)2.42844337
132retinal cone cell development (GO:0046549)2.41541933
133cochlea development (GO:0090102)2.41267575
134learning (GO:0007612)2.41113357
135establishment of nucleus localization (GO:0040023)2.39154025
136regulation of microtubule depolymerization (GO:0031114)2.38995819
137positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.37021455
138negative regulation of microtubule polymerization or depolymerization (GO:0031111)2.34222437
139behavioral response to cocaine (GO:0048148)2.31560980
140regulation of cAMP-dependent protein kinase activity (GO:2000479)2.30225560
141cellular sodium ion homeostasis (GO:0006883)2.29487782
142central nervous system projection neuron axonogenesis (GO:0021952)2.29346336
143axon extension (GO:0048675)2.29091353
144negative regulation of hormone biosynthetic process (GO:0032353)2.28105551
145regulation of dendrite morphogenesis (GO:0048814)2.26155319
146DNA unwinding involved in DNA replication (GO:0006268)2.26143618
147regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.26048876

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.39639711
2REST_21632747_ChIP-Seq_MESCs_Mouse3.22328178
3CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.90860048
4* REST_18959480_ChIP-ChIP_MESCs_Mouse2.85181754
5RARB_27405468_Chip-Seq_BRAIN_Mouse2.74138558
6RBPJ_22232070_ChIP-Seq_NCS_Mouse2.57121056
7NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.50486664
8CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.30695727
9GBX2_23144817_ChIP-Seq_PC3_Human2.27244561
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.21930086
11EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.14723457
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.07695386
13ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.01808335
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.00819210
15E2F7_22180533_ChIP-Seq_HELA_Human1.94862632
16DROSHA_22980978_ChIP-Seq_HELA_Human1.94843442
17* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.94767247
18SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.90289747
19SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.89096608
20JARID2_20064375_ChIP-Seq_MESCs_Mouse1.81540885
21* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.81318126
22JARID2_20075857_ChIP-Seq_MESCs_Mouse1.69766725
23CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.69551047
24SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.67092805
25EZH2_27304074_Chip-Seq_ESCs_Mouse1.62770441
26JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.62722834
27EP300_21415370_ChIP-Seq_HL-1_Mouse1.61964785
28ERG_21242973_ChIP-ChIP_JURKAT_Human1.60004338
29MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.57741467
30* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.57618191
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.56564765
32SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.56408487
33RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.55947901
34* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.54903700
35EZH2_18974828_ChIP-Seq_MESCs_Mouse1.54267108
36RNF2_18974828_ChIP-Seq_MESCs_Mouse1.54267108
37EZH2_27294783_Chip-Seq_ESCs_Mouse1.52511977
38MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.49481892
39SUZ12_27294783_Chip-Seq_ESCs_Mouse1.49399293
40TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49357811
41CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.47377854
42ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.47142001
43IKZF1_21737484_ChIP-ChIP_HCT116_Human1.42778518
44* ETS1_20019798_ChIP-Seq_JURKAT_Human1.42358278
45YAP1_20516196_ChIP-Seq_MESCs_Mouse1.40186267
46TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.39218070
47MTF2_20144788_ChIP-Seq_MESCs_Mouse1.39176313
48PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.39108321
49CTBP2_25329375_ChIP-Seq_LNCAP_Human1.38277747
50* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.37945364
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.37071136
52HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.36946656
53RNF2_27304074_Chip-Seq_ESCs_Mouse1.36926827
54* NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.36366510
55* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.36051651
56ZNF274_21170338_ChIP-Seq_K562_Hela1.34869514
57* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33190357
58* SMAD3_21741376_ChIP-Seq_EPCs_Human1.32987093
59MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.30218654
60SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.29552565
61AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.28037956
62* HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.27564675
63* TCF4_23295773_ChIP-Seq_U87_Human1.26620617
64TET1_21490601_ChIP-Seq_MESCs_Mouse1.26562759
65SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.26077649
66GATA1_26923725_Chip-Seq_HPCs_Mouse1.25979463
67TAF15_26573619_Chip-Seq_HEK293_Human1.25678170
68* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25282252
69YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.25064470
70POU3F2_20337985_ChIP-ChIP_501MEL_Human1.25043450
71IGF1R_20145208_ChIP-Seq_DFB_Human1.24428023
72ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.23614858
73PIAS1_25552417_ChIP-Seq_VCAP_Human1.22908920
74P53_22127205_ChIP-Seq_FIBROBLAST_Human1.22178603
75SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.21959933
76TBX3_20139965_ChIP-Seq_MESCs_Mouse1.21208687
77* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.20852226
78NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.20720515
79TBX3_20139965_ChIP-Seq_ESCs_Mouse1.20350882
80* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.18777427
81ZNF217_24962896_ChIP-Seq_MCF-7_Human1.18564972
82P300_19829295_ChIP-Seq_ESCs_Human1.17997170
83* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17157264
84CDX2_19796622_ChIP-Seq_MESCs_Mouse1.16231764
85FUS_26573619_Chip-Seq_HEK293_Human1.13611814
86TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13186663
87EED_16625203_ChIP-ChIP_MESCs_Mouse1.11945588
88TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11571984
89PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.10702374
90SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.10578585
91ISL1_27105846_Chip-Seq_CPCs_Mouse1.10543475
92NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.09386317
93CBX2_27304074_Chip-Seq_ESCs_Mouse1.09070505
94* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.08934617
95POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.08906910
96AR_21572438_ChIP-Seq_LNCaP_Human1.08726354
97POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06577092
98TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06577092
99STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.05755348
100SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.05431094
101TP53_16413492_ChIP-PET_HCT116_Human1.05377079
102TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04646227
103MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.04004813
104DNAJC2_21179169_ChIP-ChIP_NT2_Human1.03549782
105SMC4_20622854_ChIP-Seq_HELA_Human1.02271774
106TCF4_18268006_ChIP-ChIP_LS174T_Human1.02040805
107CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.01983554
108CTBP1_25329375_ChIP-Seq_LNCAP_Human1.01684589
109RNF2_27304074_Chip-Seq_NSC_Mouse0.99251165
110EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.99102890
111RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.98153334
112SMAD4_21799915_ChIP-Seq_A2780_Human0.97874368
113* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.96477739
114* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.96005919
115SOX2_21211035_ChIP-Seq_LN229_Gbm0.95577875
116TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95385275
117KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.94867285
118WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.94366255
119PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.94305463
120SALL1_21062744_ChIP-ChIP_HESCs_Human0.93353074
121TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.92446701
122NANOG_18555785_Chip-Seq_ESCs_Mouse0.92440764
123KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.91014872
124RING1B_27294783_Chip-Seq_NPCs_Mouse0.90706253
125* AR_19668381_ChIP-Seq_PC3_Human0.89845095
126* OCT4_19829295_ChIP-Seq_ESCs_Human0.89581902
127RING1B_27294783_Chip-Seq_ESCs_Mouse0.87735842
128STAT3_23295773_ChIP-Seq_U87_Human0.87515666
129OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.86661975
130KLF4_19829295_ChIP-Seq_ESCs_Human0.85441364
131HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.85178894
132NANOG_18555785_ChIP-Seq_MESCs_Mouse0.84553270
133CTCF_27219007_Chip-Seq_Bcells_Human0.83661486
134SOX9_26525672_Chip-Seq_HEART_Mouse0.83379190
135CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83064805
136* GABP_19822575_ChIP-Seq_HepG2_Human0.82180280
137NANOG_21062744_ChIP-ChIP_HESCs_Human0.81439532
138E2F1_17053090_ChIP-ChIP_MCF-7_Human0.80640655
139NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.80148262
140KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.79921965
141* KDM2B_26808549_Chip-Seq_K562_Human0.78795003
142MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.78066661
143POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.75883045
144SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.75717977
145DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.74908580
146ZFP281_27345836_Chip-Seq_ESCs_Mouse0.74868782
147ZFP57_27257070_Chip-Seq_ESCs_Mouse0.74675291
148ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.73928085
149* CIITA_25753668_ChIP-Seq_RAJI_Human0.73679303
150YY1_22570637_ChIP-Seq_MALME-3M_Human0.73246076

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.41476599
2MP0003880_abnormal_central_pattern3.81068746
3MP0003635_abnormal_synaptic_transmissio3.38442301
4MP0004270_analgesia3.03477838
5MP0009046_muscle_twitch2.78158730
6MP0002063_abnormal_learning/memory/cond2.74982263
7MP0002064_seizures2.60095114
8MP0009745_abnormal_behavioral_response2.55062772
9MP0002734_abnormal_mechanical_nocicepti2.31529548
10MP0002572_abnormal_emotion/affect_behav2.31371296
11MP0005423_abnormal_somatic_nervous2.28045658
12MP0002822_catalepsy2.27639771
13MP0001968_abnormal_touch/_nociception2.23342787
14MP0002272_abnormal_nervous_system2.17113138
15MP0006072_abnormal_retinal_apoptosis2.08142843
16MP0001486_abnormal_startle_reflex2.03857338
17MP0002909_abnormal_adrenal_gland1.93793273
18MP0002653_abnormal_ependyma_morphology1.80183878
19MP0003122_maternal_imprinting1.79743298
20MP0003879_abnormal_hair_cell1.78713680
21MP0008877_abnormal_DNA_methylation1.74715127
22MP0005551_abnormal_eye_electrophysiolog1.74103038
23MP0002067_abnormal_sensory_capabilities1.72521254
24MP0002733_abnormal_thermal_nociception1.71963687
25MP0006292_abnormal_olfactory_placode1.71816629
26MP0001970_abnormal_pain_threshold1.71030375
27MP0000566_synostosis1.70298010
28MP0005646_abnormal_pituitary_gland1.69446670
29MP0001984_abnormal_olfaction1.68963718
30MP0005645_abnormal_hypothalamus_physiol1.67853755
31MP0002184_abnormal_innervation1.67471262
32MP0001440_abnormal_grooming_behavior1.65427297
33MP0001529_abnormal_vocalization1.64953368
34MP0004811_abnormal_neuron_physiology1.61726226
35MP0003123_paternal_imprinting1.61021281
36MP0002736_abnormal_nociception_after1.57828979
37MP0008569_lethality_at_weaning1.56630254
38MP0003787_abnormal_imprinting1.56017412
39MP0001501_abnormal_sleep_pattern1.52904839
40MP0002638_abnormal_pupillary_reflex1.52428476
41MP0002735_abnormal_chemical_nociception1.51459721
42MP0006276_abnormal_autonomic_nervous1.48405496
43MP0004924_abnormal_behavior1.48291892
44MP0005386_behavior/neurological_phenoty1.48291892
45MP0009780_abnormal_chondrocyte_physiolo1.47134569
46MP0002557_abnormal_social/conspecific_i1.45258485
47MP0008260_abnormal_autophagy1.45000700
48MP0004147_increased_porphyrin_level1.44838601
49MP0000955_abnormal_spinal_cord1.43791221
50MP0000013_abnormal_adipose_tissue1.41456458
51MP0000751_myopathy1.39915599
52MP0000778_abnormal_nervous_system1.35131071
53MP0002882_abnormal_neuron_morphology1.34279895
54MP0010386_abnormal_urinary_bladder1.33513538
55MP0001502_abnormal_circadian_rhythm1.29511806
56MP0001299_abnormal_eye_distance/1.29351243
57MP0004145_abnormal_muscle_electrophysio1.25910317
58MP0005187_abnormal_penis_morphology1.25651920
59MP0002066_abnormal_motor_capabilities/c1.25423601
60MP0003329_amyloid_beta_deposits1.24545146
61MP0008789_abnormal_olfactory_epithelium1.21957727
62MP0001188_hyperpigmentation1.21916127
63MP0003121_genomic_imprinting1.21875500
64MP0005253_abnormal_eye_physiology1.20899555
65MP0008057_abnormal_DNA_replication1.20349472
66MP0004885_abnormal_endolymph1.19114357
67MP0004233_abnormal_muscle_weight1.17062604
68MP0000749_muscle_degeneration1.15673722
69MP0004043_abnormal_pH_regulation1.14616499
70MP0004142_abnormal_muscle_tone1.14193508
71MP0001905_abnormal_dopamine_level1.12985705
72MP0003693_abnormal_embryo_hatching1.12713178
73MP0005394_taste/olfaction_phenotype1.12425990
74MP0005499_abnormal_olfactory_system1.12425990
75MP0001346_abnormal_lacrimal_gland1.10480403
76MP0010030_abnormal_orbit_morphology1.10194246
77MP0002152_abnormal_brain_morphology1.09396457
78MP0003283_abnormal_digestive_organ1.08013008
79MP0005623_abnormal_meninges_morphology1.07904515
80MP0002229_neurodegeneration1.07903650
81MP0005409_darkened_coat_color1.06630435
82* MP0003111_abnormal_nucleus_morphology1.02674005
83MP0001177_atelectasis1.02650180
84MP0002233_abnormal_nose_morphology1.02456738
85MP0004858_abnormal_nervous_system1.00567413
86MP0003937_abnormal_limbs/digits/tail_de0.99596879
87MP0000631_abnormal_neuroendocrine_gland0.99251156
88MP0000579_abnormal_nail_morphology0.98244807
89MP0004084_abnormal_cardiac_muscle0.93385288
90MP0003119_abnormal_digestive_system0.91666231
91MP0002069_abnormal_eating/drinking_beha0.88740253
92MP0002876_abnormal_thyroid_physiology0.88219329
93MP0002234_abnormal_pharynx_morphology0.87444957
94MP0002752_abnormal_somatic_nervous0.86820801
95* MP0003698_abnormal_male_reproductive0.86073963
96MP0003950_abnormal_plasma_membrane0.82507616
97MP0002084_abnormal_developmental_patter0.81329534
98MP0001986_abnormal_taste_sensitivity0.80023311
99MP0003633_abnormal_nervous_system0.79659475
100MP0003938_abnormal_ear_development0.79606742
101MP0003656_abnormal_erythrocyte_physiolo0.78148557
102MP0003631_nervous_system_phenotype0.77169587
103MP0003935_abnormal_craniofacial_develop0.75447590
104MP0000569_abnormal_digit_pigmentation0.75022648
105MP0003861_abnormal_nervous_system0.74954038
106MP0008872_abnormal_physiological_respon0.74658545
107MP0004036_abnormal_muscle_relaxation0.74564811
108MP0000428_abnormal_craniofacial_morphol0.73541553
109MP0002090_abnormal_vision0.73084578
110MP0003890_abnormal_embryonic-extraembry0.72972186
111MP0003718_maternal_effect0.72570465
112MP0002081_perinatal_lethality0.72381707
113MP0003137_abnormal_impulse_conducting0.71826024
114MP0002751_abnormal_autonomic_nervous0.71502499
115MP0002269_muscular_atrophy0.71371918
116MP0004215_abnormal_myocardial_fiber0.69260512
117MP0001963_abnormal_hearing_physiology0.68683629
118MP0003646_muscle_fatigue0.68224642
119MP0002697_abnormal_eye_size0.67462369
120MP0003634_abnormal_glial_cell0.67360372
121* MP0001929_abnormal_gametogenesis0.66865624
122MP0002102_abnormal_ear_morphology0.66194154
123MP0006138_congestive_heart_failure0.66178593
124MP0005410_abnormal_fertilization0.66177044
125MP0008058_abnormal_DNA_repair0.65539657
126MP0004087_abnormal_muscle_fiber0.65265743
127MP0002085_abnormal_embryonic_tissue0.63981361
128MP0001485_abnormal_pinna_reflex0.63728287
129MP0003755_abnormal_palate_morphology0.63697506
130MP0001293_anophthalmia0.63467667
131MP0004085_abnormal_heartbeat0.63044158
132MP0006035_abnormal_mitochondrial_morpho0.62629750
133* MP0002161_abnormal_fertility/fecundity0.62558945

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.90067974
2Myokymia (HP:0002411)5.16253334
3Visual hallucinations (HP:0002367)4.34338768
4Focal seizures (HP:0007359)4.28666454
5Epileptic encephalopathy (HP:0200134)4.07423720
6Atonic seizures (HP:0010819)3.53929377
7Febrile seizures (HP:0002373)3.48690092
8Absence seizures (HP:0002121)3.43789454
9Progressive cerebellar ataxia (HP:0002073)3.39585716
10Ankle clonus (HP:0011448)3.38971906
11Decreased number of large peripheral myelinated nerve fibers (HP:0003387)3.30908757
12Dialeptic seizures (HP:0011146)3.29888787
13Abnormality of the lower motor neuron (HP:0002366)3.29627006
14Generalized tonic-clonic seizures (HP:0002069)3.12224424
15Congenital stationary night blindness (HP:0007642)2.99398727
16Cerebral hypomyelination (HP:0006808)2.91857373
17Ventricular fibrillation (HP:0001663)2.88966076
18Epileptiform EEG discharges (HP:0011182)2.68944233
19Broad-based gait (HP:0002136)2.65970916
20Papillary thyroid carcinoma (HP:0002895)2.65160643
21EEG with generalized epileptiform discharges (HP:0011198)2.65025207
22Delusions (HP:0000746)2.60931500
23Genetic anticipation (HP:0003743)2.54096947
24Poor eye contact (HP:0000817)2.52479717
25Hypsarrhythmia (HP:0002521)2.51947558
26Unsteady gait (HP:0002317)2.49933814
27Depression (HP:0000716)2.47327421
28Abnormality of the labia minora (HP:0012880)2.45502216
29Gait imbalance (HP:0002141)2.41945892
30Abnormal eating behavior (HP:0100738)2.41342919
31Supranuclear gaze palsy (HP:0000605)2.39735850
32Bundle branch block (HP:0011710)2.39345484
33Gaze-evoked nystagmus (HP:0000640)2.36878897
34Truncal ataxia (HP:0002078)2.36359995
35Action tremor (HP:0002345)2.36230372
36Urinary bladder sphincter dysfunction (HP:0002839)2.34802430
37Lower limb muscle weakness (HP:0007340)2.32686524
38Impaired vibration sensation in the lower limbs (HP:0002166)2.31602349
39Impaired social interactions (HP:0000735)2.29008669
40Abnormal social behavior (HP:0012433)2.29008669
41Abnormality of the septum pellucidum (HP:0007375)2.27927696
42Failure to thrive in infancy (HP:0001531)2.27681450
43Mutism (HP:0002300)2.27083436
44Drooling (HP:0002307)2.22978321
45Excessive salivation (HP:0003781)2.22978321
46Bony spicule pigmentary retinopathy (HP:0007737)2.22145797
47CNS hypomyelination (HP:0003429)2.21878510
48Impaired smooth pursuit (HP:0007772)2.21560969
49Anxiety (HP:0000739)2.19640049
50Clonus (HP:0002169)2.17544466
51Absent septum pellucidum (HP:0001331)2.15259122
52Hyperventilation (HP:0002883)2.14595437
53Congenital primary aphakia (HP:0007707)2.13895610
54Medial flaring of the eyebrow (HP:0010747)2.13557148
55Pancreatic fibrosis (HP:0100732)2.12637145
56Hepatoblastoma (HP:0002884)2.12423275
57Abnormality of the corticospinal tract (HP:0002492)2.12148356
58Postural instability (HP:0002172)2.12131351
59Bradykinesia (HP:0002067)2.11947542
60Dysdiadochokinesis (HP:0002075)2.11664933
61Absent speech (HP:0001344)2.11233493
62Fetal akinesia sequence (HP:0001989)2.11040335
63Abnormal rod and cone electroretinograms (HP:0008323)2.10371592
64Spastic gait (HP:0002064)2.09670698
65Aplasia involving bones of the upper limbs (HP:0009823)2.08219054
66Aplasia of the phalanges of the hand (HP:0009802)2.08219054
67Aplasia involving bones of the extremities (HP:0009825)2.08219054
68Polyphagia (HP:0002591)2.08105206
69Amyotrophic lateral sclerosis (HP:0007354)2.07125793
70Hemiparesis (HP:0001269)2.06804976
71Peripheral hypomyelination (HP:0007182)2.06348403
72Central scotoma (HP:0000603)2.06218137
73Nephrogenic diabetes insipidus (HP:0009806)2.03326897
74Vertebral arch anomaly (HP:0008438)1.98356753
75Torticollis (HP:0000473)1.97451454
76Shoulder girdle muscle weakness (HP:0003547)1.95930157
77Abnormality of ocular smooth pursuit (HP:0000617)1.94673283
78Agitation (HP:0000713)1.94572674
79Abnormality of cochlea (HP:0000375)1.94337166
80Alacrima (HP:0000522)1.93116596
81Urinary urgency (HP:0000012)1.92747232
82Sleep apnea (HP:0010535)1.92296603
83Hammertoe (HP:0001765)1.91472608
84Dysmetric saccades (HP:0000641)1.90015169
85Dysautonomia (HP:0002459)1.88573336
86Neurofibrillary tangles (HP:0002185)1.88327341
87Focal dystonia (HP:0004373)1.88124115
88Tetraplegia (HP:0002445)1.86618131
89Restlessness (HP:0000711)1.84963860
90Annular pancreas (HP:0001734)1.84479492
91Limb dystonia (HP:0002451)1.83794710
92Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.83127933
93Sudden death (HP:0001699)1.83026090
94Atrophy/Degeneration involving motor neurons (HP:0007373)1.82157595
95Obstructive sleep apnea (HP:0002870)1.81791210
96Spinal muscular atrophy (HP:0007269)1.80910679
97Progressive inability to walk (HP:0002505)1.80730607
98Cutaneous finger syndactyly (HP:0010554)1.80670960
99Poor coordination (HP:0002370)1.80331877
100Pheochromocytoma (HP:0002666)1.80055019
101Abnormality of binocular vision (HP:0011514)1.79954371
102Diplopia (HP:0000651)1.79954371
103Insomnia (HP:0100785)1.79278469
104Decreased lacrimation (HP:0000633)1.77744722
105Supernumerary spleens (HP:0009799)1.77467062
106Apathy (HP:0000741)1.76175002
107Diastasis recti (HP:0001540)1.76171409
108Abnormality of macular pigmentation (HP:0008002)1.75385951
109Dysmetria (HP:0001310)1.75334868
110Deep palmar crease (HP:0006191)1.75011320
111Absent rod-and cone-mediated responses on ERG (HP:0007688)1.74417042
112Impaired vibratory sensation (HP:0002495)1.73395933
113Calcaneovalgus deformity (HP:0001848)1.73316412
114Tracheomalacia (HP:0002779)1.71887173
115Pointed chin (HP:0000307)1.71697496
116Cerebral inclusion bodies (HP:0100314)1.70446706
117Amblyopia (HP:0000646)1.69367525
118High anterior hairline (HP:0009890)1.65682646
119Inability to walk (HP:0002540)1.65579355
120Abnormal EKG (HP:0003115)1.64310692
121Bronchomalacia (HP:0002780)1.64224387
122Pancreatic cysts (HP:0001737)1.64139906
123Exercise-induced muscle cramps (HP:0003710)1.63865397
124Abnormality of pain sensation (HP:0010832)1.63823950
125Impaired pain sensation (HP:0007328)1.63823950
126Split foot (HP:0001839)1.63767632
127Abnormality of midbrain morphology (HP:0002418)1.62300640
128Molar tooth sign on MRI (HP:0002419)1.62300640
129Craniofacial dystonia (HP:0012179)1.62164977
130Neuroendocrine neoplasm (HP:0100634)1.61891055
131Abnormality of the left ventricular outflow tract (HP:0011103)1.61467910
132Subaortic stenosis (HP:0001682)1.61467910
133Type II diabetes mellitus (HP:0005978)1.60834396
134Scotoma (HP:0000575)1.60795401
135Cortical dysplasia (HP:0002539)1.60103181
136Poor suck (HP:0002033)1.59437478
137Intention tremor (HP:0002080)1.59364427
138Specific learning disability (HP:0001328)1.59251629
139Stereotypic behavior (HP:0000733)1.58136048
140Cutaneous syndactyly (HP:0012725)1.57901194
141Lower limb amyotrophy (HP:0007210)1.57397150
142Abnormality of the phalanges of the hallux (HP:0010057)1.56187363
143Patent foramen ovale (HP:0001655)1.55404523
144Male infertility (HP:0003251)1.54644600
145Diminished motivation (HP:0000745)1.51964998
146Overriding aorta (HP:0002623)1.51021081
147Partial agenesis of the corpus callosum (HP:0001338)1.50500799
148Septo-optic dysplasia (HP:0100842)1.50419272
149Hand muscle atrophy (HP:0009130)1.50396193
150Morphological abnormality of the inner ear (HP:0011390)1.50022557
151Termporal pattern (HP:0011008)1.49651906
152Insidious onset (HP:0003587)1.49651906
153Heterotopia (HP:0002282)1.49074489
154Neuronal loss in central nervous system (HP:0002529)1.48229114

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK38L3.76914308
2NTRK33.51241981
3EPHA43.37324869
4MAP3K93.35661695
5MARK13.13608871
6PNCK2.63847777
7AKT32.58458929
8NEK12.55343217
9PRKD32.22120188
10MAP3K42.19976806
11MINK12.11202014
12ARAF2.07306716
13BUB12.04626255
14MAP2K72.00184920
15PAK61.90991029
16WNK11.82053232
17DAPK21.73120510
18NTRK21.71932938
19PINK11.67468357
20BRAF1.64500913
21DAPK11.64101589
22TSSK61.61181848
23BRSK11.57494046
24NTRK11.54767741
25STK381.54132059
26WEE11.52614606
27WNK31.51018473
28BCR1.46012106
29TRIM281.44524638
30CCNB11.41589655
31KSR11.40581285
32KSR21.39630410
33CASK1.37638275
34PRKCG1.37584990
35MAP3K121.35850153
36CAMKK11.32616497
37BRD41.29612270
38STK161.28430496
39CDK191.26562628
40OBSCN1.20707981
41CDK51.16023560
42CAMKK21.15299735
43DMPK1.13145005
44MAP2K41.12041842
45MAPK131.09591161
46PLK21.07204238
47UHMK11.05674337
48LMTK21.05350373
49PDK41.04887708
50PDK31.04887708
51TAOK11.02514457
52CDK121.00933765
53GRK50.99716833
54PLK30.98326872
55LATS20.96751180
56CDK180.89944746
57CDK150.87380612
58CAMK1G0.85644220
59SGK4940.84034140
60SGK2230.84034140
61CDK140.83577452
62RAF10.83188261
63ALK0.83055361
64CSNK1A1L0.81676316
65PRPF4B0.80270851
66PAK30.79413183
67CDK11A0.79214583
68DYRK1A0.78440122
69NME10.78280364
70CSNK1G10.77881259
71SGK20.77053606
72TTK0.72654432
73LATS10.71487428
74EIF2AK10.71186383
75CSNK1G30.70700694
76TYRO30.70331376
77PHKG20.67613791
78PHKG10.67613791
79CAMK10.67104081
80FGFR20.67038562
81PLK10.65467905
82CAMK40.63764583
83CSNK1D0.63510081
84PTK20.61013628
85BMPR20.60920537
86CDC42BPA0.60756727
87PDK20.60314230
88EPHA20.59646457
89MAPK150.58678181
90RIPK40.58678138
91MAPK100.58642415
92MET0.58204488
93LIMK10.58060441
94CDC70.57659242
95SIK20.57332106
96CSNK1G20.56981038
97TNIK0.56954670
98MARK20.56407012
99MAP3K50.55432684
100AURKA0.55247228
101CAMK2A0.54388584
102SCYL20.53993791
103ICK0.52641359
104CAMK2G0.51921916
105CAMK2B0.51770788
106SGK30.51345852
107CAMK2D0.50138950
108PLK40.49643711
109STK240.49499624
110DYRK30.49177956
111MAP3K20.48691235
112PRKAA10.48597285
113PKN10.48183914
114STK110.47739946
115CHEK20.46876575
116EEF2K0.46646321
117RPS6KB10.45799388
118BRSK20.44330518
119PRKCE0.44085242
120RPS6KA30.43920412
121FES0.43283760
122PRKCZ0.43072636
123SGK10.41709094
124SRPK10.41409942
125CSNK1E0.41357665
126DYRK20.39317217
127PRKCI0.39281993
128NEK60.38635842
129TAOK20.38127715

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047214.04734941
2Nicotine addiction_Homo sapiens_hsa050333.55453656
3GABAergic synapse_Homo sapiens_hsa047272.69175724
4Olfactory transduction_Homo sapiens_hsa047402.62332719
5Circadian entrainment_Homo sapiens_hsa047132.45690247
6Amphetamine addiction_Homo sapiens_hsa050312.42809132
7Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.39291269
8Insulin secretion_Homo sapiens_hsa049112.29874887
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.29125969
10Morphine addiction_Homo sapiens_hsa050322.20155462
11Long-term potentiation_Homo sapiens_hsa047202.16417116
12Glutamatergic synapse_Homo sapiens_hsa047242.14439915
13Phototransduction_Homo sapiens_hsa047442.11420853
14Dopaminergic synapse_Homo sapiens_hsa047282.02114688
15Collecting duct acid secretion_Homo sapiens_hsa049661.91842300
16Regulation of autophagy_Homo sapiens_hsa041401.91768073
17Vitamin B6 metabolism_Homo sapiens_hsa007501.79956795
18* Oocyte meiosis_Homo sapiens_hsa041141.72210004
19Cholinergic synapse_Homo sapiens_hsa047251.60790157
20Taste transduction_Homo sapiens_hsa047421.57525589
21Salivary secretion_Homo sapiens_hsa049701.51876924
22Cocaine addiction_Homo sapiens_hsa050301.51677560
23Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.49344623
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.47560082
25Oxytocin signaling pathway_Homo sapiens_hsa049211.36842009
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.36109203
27Serotonergic synapse_Homo sapiens_hsa047261.30590162
28Proteasome_Homo sapiens_hsa030501.27224805
29Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.27107838
30Calcium signaling pathway_Homo sapiens_hsa040201.25435290
31Gastric acid secretion_Homo sapiens_hsa049711.25025056
32Dilated cardiomyopathy_Homo sapiens_hsa054141.24761849
33Long-term depression_Homo sapiens_hsa047301.22237212
34Vibrio cholerae infection_Homo sapiens_hsa051101.21441218
35Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.17143487
36Gap junction_Homo sapiens_hsa045401.13307454
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.11065369
38Type II diabetes mellitus_Homo sapiens_hsa049301.10954521
39Renin secretion_Homo sapiens_hsa049241.08943586
40Adherens junction_Homo sapiens_hsa045201.08877002
41Fructose and mannose metabolism_Homo sapiens_hsa000511.06904827
42RNA transport_Homo sapiens_hsa030131.05682665
43Phosphatidylinositol signaling system_Homo sapiens_hsa040701.04629898
44* Hippo signaling pathway_Homo sapiens_hsa043901.03610467
45* Circadian rhythm_Homo sapiens_hsa047101.02223701
46GnRH signaling pathway_Homo sapiens_hsa049121.01806529
47Tight junction_Homo sapiens_hsa045301.01129774
48RNA polymerase_Homo sapiens_hsa030200.98863862
49mTOR signaling pathway_Homo sapiens_hsa041500.95773639
50cAMP signaling pathway_Homo sapiens_hsa040240.95753578
51Estrogen signaling pathway_Homo sapiens_hsa049150.95398590
52Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.94719211
53Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.94638631
54Glycerophospholipid metabolism_Homo sapiens_hsa005640.94604665
55Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.90852762
56Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.86099327
57Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.85517927
58* Hedgehog signaling pathway_Homo sapiens_hsa043400.82512502
59Maturity onset diabetes of the young_Homo sapiens_hsa049500.82308775
60ErbB signaling pathway_Homo sapiens_hsa040120.81785223
61cGMP-PKG signaling pathway_Homo sapiens_hsa040220.81210884
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81020599
63Cardiac muscle contraction_Homo sapiens_hsa042600.80236749
64mRNA surveillance pathway_Homo sapiens_hsa030150.80090007
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79816324
66Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.79722292
67Alcoholism_Homo sapiens_hsa050340.79144249
68* Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.75354088
69Inositol phosphate metabolism_Homo sapiens_hsa005620.74929397
70Glioma_Homo sapiens_hsa052140.71119667
71Vascular smooth muscle contraction_Homo sapiens_hsa042700.68775546
72Renal cell carcinoma_Homo sapiens_hsa052110.68532826
73Purine metabolism_Homo sapiens_hsa002300.68379150
74Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68215735
75Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67449202
76Melanogenesis_Homo sapiens_hsa049160.67412730
77Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.67411673
78Bile secretion_Homo sapiens_hsa049760.66484678
79Basal cell carcinoma_Homo sapiens_hsa052170.66144576
80Ras signaling pathway_Homo sapiens_hsa040140.66017540
81Endocytosis_Homo sapiens_hsa041440.64514785
82Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63764307
83AMPK signaling pathway_Homo sapiens_hsa041520.62873610
84Non-homologous end-joining_Homo sapiens_hsa034500.62442166
85Rap1 signaling pathway_Homo sapiens_hsa040150.61880137
86Glucagon signaling pathway_Homo sapiens_hsa049220.58793738
87Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58689879
88SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56614246
892-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.56410185
90Lysine degradation_Homo sapiens_hsa003100.54881017
91Arginine biosynthesis_Homo sapiens_hsa002200.53343684
92Spliceosome_Homo sapiens_hsa030400.50923237
93Choline metabolism in cancer_Homo sapiens_hsa052310.50120631
94ECM-receptor interaction_Homo sapiens_hsa045120.49972071
95Axon guidance_Homo sapiens_hsa043600.49779488
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.49136899
97Neurotrophin signaling pathway_Homo sapiens_hsa047220.48909883
98Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.48537424
99Steroid biosynthesis_Homo sapiens_hsa001000.47156015
100MicroRNAs in cancer_Homo sapiens_hsa052060.46932742
101Central carbon metabolism in cancer_Homo sapiens_hsa052300.46625894
102Pancreatic secretion_Homo sapiens_hsa049720.46498194
103Focal adhesion_Homo sapiens_hsa045100.45935064
104Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.45585411
105Ovarian steroidogenesis_Homo sapiens_hsa049130.45530533
106Basal transcription factors_Homo sapiens_hsa030220.45400235
107MAPK signaling pathway_Homo sapiens_hsa040100.45283986
108Insulin signaling pathway_Homo sapiens_hsa049100.44869552
109Type I diabetes mellitus_Homo sapiens_hsa049400.44312689
110Cell cycle_Homo sapiens_hsa041100.44166036
111Arginine and proline metabolism_Homo sapiens_hsa003300.42988445
112Cysteine and methionine metabolism_Homo sapiens_hsa002700.42725594
113Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42088543
114Endometrial cancer_Homo sapiens_hsa052130.41251563
115Dorso-ventral axis formation_Homo sapiens_hsa043200.41032225
116Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40874435
117Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40849769
118Thyroid hormone synthesis_Homo sapiens_hsa049180.39758218
119Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.38484573
120Colorectal cancer_Homo sapiens_hsa052100.37261303
121* Wnt signaling pathway_Homo sapiens_hsa043100.36661133
122Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36412221
123Mismatch repair_Homo sapiens_hsa034300.33688006
124Pyrimidine metabolism_Homo sapiens_hsa002400.32541733
125Biosynthesis of amino acids_Homo sapiens_hsa012300.31745192
126Base excision repair_Homo sapiens_hsa034100.30958467

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