BTN2A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the immunoglobulin superfamily. The gene is located in a cluster of butyrophilin-like genes in the juxta-telomeric region of the major histocompatibility complex on chromosome 6. A pseudogene of this gene has been identified in this cluster. The encoded protein is an integral plasma membrane protein involved in lipid, fatty-acid, and sterol metabolism. Alterations in this gene may be associated with several disease states including metabolic syndrome. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)6.19557852
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.19557852
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.46136107
4positive regulation of gamma-delta T cell activation (GO:0046645)5.31551603
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.24920745
6positive regulation by symbiont of host defense response (GO:0052509)5.04333717
7modulation by symbiont of host defense response (GO:0052031)5.04333717
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.04333717
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.04333717
10positive regulation by organism of defense response of other organism involved in symbiotic interact5.04333717
11modulation by symbiont of host immune response (GO:0052553)5.04333717
12antigen processing and presentation of endogenous antigen (GO:0019883)4.93480313
13antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.82408610
14neutrophil activation involved in immune response (GO:0002283)4.46669372
15response to peptidoglycan (GO:0032494)4.34410510
16detection of other organism (GO:0098543)4.33011482
17macrophage activation involved in immune response (GO:0002281)4.27925540
18positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.19950909
19positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.18349689
20regulation of B cell receptor signaling pathway (GO:0050855)4.16975062
21detection of bacterium (GO:0016045)4.12106263
22leukocyte aggregation (GO:0070486)4.07369138
23negative regulation of interleukin-12 production (GO:0032695)4.03997964
24detection of molecule of bacterial origin (GO:0032490)4.01787381
25regulation of interferon-beta biosynthetic process (GO:0045357)3.88268628
26negative regulation of lymphocyte mediated immunity (GO:0002707)3.87800775
27regulation of gamma-delta T cell activation (GO:0046643)3.86706765
28detection of external biotic stimulus (GO:0098581)3.85745678
29type I interferon signaling pathway (GO:0060337)3.72735130
30cellular response to type I interferon (GO:0071357)3.72735130
31response to type I interferon (GO:0034340)3.70133135
32neutrophil activation (GO:0042119)3.69453181
33response to interleukin-15 (GO:0070672)3.65790338
34cellular extravasation (GO:0045123)3.62900370
35response to muramyl dipeptide (GO:0032495)3.62731274
36regulation of T cell tolerance induction (GO:0002664)3.60955665
37granulocyte activation (GO:0036230)3.55997324
38antigen processing and presentation via MHC class Ib (GO:0002475)3.49182896
39negative regulation of T cell mediated immunity (GO:0002710)3.41963338
40negative regulation of leukocyte mediated immunity (GO:0002704)3.40458614
41negative thymic T cell selection (GO:0045060)3.39400154
42detection of biotic stimulus (GO:0009595)3.38750160
43negative T cell selection (GO:0043383)3.37225072
44response to host immune response (GO:0052572)3.36621835
45response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.36621835
46regulation of tolerance induction (GO:0002643)3.34445481
47regulation of dendritic cell antigen processing and presentation (GO:0002604)3.29296044
48regulation of gamma-delta T cell differentiation (GO:0045586)3.25945892
49cellular response to interleukin-15 (GO:0071350)3.22960296
50immunoglobulin mediated immune response (GO:0016064)3.22953999
51respiratory burst (GO:0045730)3.22877381
52microglial cell activation (GO:0001774)3.22305763
53germinal center formation (GO:0002467)3.21187076
54negative regulation of erythrocyte differentiation (GO:0045647)3.20027193
55response to host (GO:0075136)3.18716283
56response to host defenses (GO:0052200)3.18716283
57response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.18716283
58macrophage activation (GO:0042116)3.18423328
59neutrophil mediated immunity (GO:0002446)3.17215390
60interferon-gamma-mediated signaling pathway (GO:0060333)3.17035714
61myeloid cell activation involved in immune response (GO:0002275)3.15352251
62positive regulation of tolerance induction (GO:0002645)3.10064243
63regulation of mast cell degranulation (GO:0043304)3.08902309
64tolerance induction (GO:0002507)3.07552433
65regulation of T-helper 2 cell differentiation (GO:0045628)3.00615800
66defense response to protozoan (GO:0042832)2.99729969
67regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.99580480
68lipopolysaccharide-mediated signaling pathway (GO:0031663)2.98129657
69B cell receptor signaling pathway (GO:0050853)2.96244690
70NIK/NF-kappaB signaling (GO:0038061)2.95465666
71production of molecular mediator involved in inflammatory response (GO:0002532)2.94469196
72T cell migration (GO:0072678)2.93840299
73positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.92607732
74activated T cell proliferation (GO:0050798)2.90938235
75positive thymic T cell selection (GO:0045059)2.90188573
76myeloid leukocyte mediated immunity (GO:0002444)2.89912979
77regulation of necroptotic process (GO:0060544)2.87985688
78negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.87659691
79positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.87513134
80positive regulation of interferon-alpha production (GO:0032727)2.86457879
81leukocyte migration involved in inflammatory response (GO:0002523)2.84435917
82regulation of B cell differentiation (GO:0045577)2.84230915
83regulation of natural killer cell mediated immunity (GO:0002715)2.84015710
84regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.84015710
85regulation of mast cell activation involved in immune response (GO:0033006)2.83422850
86negative regulation of type 2 immune response (GO:0002829)2.83387125
87regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.83183739
88negative regulation of innate immune response (GO:0045824)2.77326356
89regulation of T cell mediated cytotoxicity (GO:0001914)2.76882248
90regulation of interferon-alpha production (GO:0032647)2.76564380
91regulation of myeloid leukocyte mediated immunity (GO:0002886)2.74309624
92T cell selection (GO:0045058)2.71631837
93positive T cell selection (GO:0043368)2.71581396
94I-kappaB phosphorylation (GO:0007252)2.69993557
95negative regulation of cytokine production involved in immune response (GO:0002719)2.69965191
96response to protozoan (GO:0001562)2.68364987
97response to interferon-alpha (GO:0035455)2.68249188
98regulation of regulatory T cell differentiation (GO:0045589)2.66857680
99interferon-gamma secretion (GO:0072643)2.66387384
100negative regulation of glycoprotein biosynthetic process (GO:0010561)2.65191365

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.34878056
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.52367775
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.08318758
4IRF8_21731497_ChIP-ChIP_J774_Mouse4.01784089
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.59568584
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.55469230
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.28831817
8IRF8_27001747_Chip-Seq_BMDM_Mouse3.13626106
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.92795109
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.91617766
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.82583781
12SMAD_19615063_ChIP-ChIP_OVARY_Human2.82380874
13RUNX_20019798_ChIP-Seq_JUKART_Human2.73175085
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.71829852
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.70027335
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.64234714
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.42067226
18* SPI1_23547873_ChIP-Seq_NB4_Human2.37030249
19MAF_26560356_Chip-Seq_TH1_Human2.27853670
20SPI1_23127762_ChIP-Seq_K562_Human2.27300639
21MYB_26560356_Chip-Seq_TH2_Human2.27232592
22FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.25525404
23VDR_24763502_ChIP-Seq_THP-1_Human2.23606684
24RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.22904429
25NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.21769657
26RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.19114884
27STAT4_19710469_ChIP-ChIP_TH1__Mouse2.16680895
28Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.15483020
29VDR_21846776_ChIP-Seq_THP-1_Human2.11733364
30SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.04131594
31RUNX1_22412390_ChIP-Seq_EML_Mouse2.02565277
32CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.98589512
33E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.97463944
34UTX_26944678_Chip-Seq_JUKART_Human1.97037301
35VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.96327567
36KDM2B_26808549_Chip-Seq_SUP-B15_Human1.96181886
37BRD4_27068464_Chip-Seq_AML-cells_Mouse1.92832523
38MYB_26560356_Chip-Seq_TH1_Human1.92489973
39TCF7_22412390_ChIP-Seq_EML_Mouse1.87570123
40VDR_24787735_ChIP-Seq_THP-1_Human1.77342010
41KDM2B_26808549_Chip-Seq_DND41_Human1.76521335
42KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.74148607
43MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.73753239
44MAF_26560356_Chip-Seq_TH2_Human1.72692766
45THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.71868859
46SCL_19346495_ChIP-Seq_HPC-7_Human1.68278171
47MYC_22102868_ChIP-Seq_BL_Human1.67797149
48ELK3_25401928_ChIP-Seq_HUVEC_Human1.66421483
49KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.60695954
50GATA3_27048872_Chip-Seq_THYMUS_Human1.58408542
51CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.55765734
52GATA2_21666600_ChIP-Seq_HMVEC_Human1.54948688
53LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.53130381
54ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.50638767
55LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.46254586
56PU_27001747_Chip-Seq_BMDM_Mouse1.39482738
57GATA1_19941827_ChIP-Seq_MEL_Mouse1.38751633
58TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.37520662
59KDM2B_26808549_Chip-Seq_JURKAT_Human1.35773560
60GATA2_22383799_ChIP-Seq_G1ME_Mouse1.34804090
61TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.29676371
62CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.26890223
63GATA3_26560356_Chip-Seq_TH2_Human1.23117924
64PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23019794
65PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20721232
66PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16654483
67CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16605070
68GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.16391183
69FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.15139872
70NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.12542599
71GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12224314
72PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11356385
73SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.11114193
74CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10761738
75STAT6_21828071_ChIP-Seq_BEAS2B_Human1.08221763
76BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.07734806
77GATA1_22383799_ChIP-Seq_G1ME_Mouse1.02688467
78SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99529187
79LXR_22292898_ChIP-Seq_THP-1_Human0.99277543
80RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.97463627
81SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.94771370
82CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.94001748
83GATA1_19941826_ChIP-Seq_K562_Human0.93160608
84PU.1_20513432_ChIP-Seq_Bcells_Mouse0.92605270
85GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91628864
86IKZF1_21737484_ChIP-ChIP_HCT116_Human0.86745684
87STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.86382158
88RARG_19884340_ChIP-ChIP_MEFs_Mouse0.85831432
89* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85719403
90CTCF_27219007_Chip-Seq_ERYTHROID_Human0.82125951
91KDM2B_26808549_Chip-Seq_K562_Human0.81800299
92RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79378109
93RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.77342470
94STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.77085126
95GATA2_19941826_ChIP-Seq_K562_Human0.76945167
96ELF1_17652178_ChIP-ChIP_JURKAT_Human0.76727480
97TFEB_21752829_ChIP-Seq_HELA_Human0.75978332
98TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.74592509
99BCL6_27268052_Chip-Seq_Bcells_Human0.74423082
100FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.72580056

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.89244950
2MP0003436_decreased_susceptibility_to4.48317152
3MP0003303_peritoneal_inflammation3.74320592
4MP0001835_abnormal_antigen_presentation3.46854092
5MP0002419_abnormal_innate_immunity2.86452492
6MP0009785_altered_susceptibility_to2.84839030
7MP0006082_CNS_inflammation2.80548722
8MP0001800_abnormal_humoral_immune2.79744106
9MP0005387_immune_system_phenotype2.79083546
10MP0001790_abnormal_immune_system2.79083546
11MP0005000_abnormal_immune_tolerance2.77740618
12MP0005671_abnormal_response_to2.77186727
13MP0005025_abnormal_response_to2.63985754
14MP0002723_abnormal_immune_serum2.50417185
15MP0000685_abnormal_immune_system2.49278490
16MP0002452_abnormal_antigen_presenting2.42041857
17MP0003300_gastrointestinal_ulcer2.36012296
18MP0002420_abnormal_adaptive_immunity2.32978594
19MP0001819_abnormal_immune_cell2.31535449
20MP0001533_abnormal_skeleton_physiology2.30903813
21MP0002148_abnormal_hypersensitivity_rea2.28479903
22MP0003172_abnormal_lysosome_physiology2.22664461
23MP0003191_abnormal_cellular_cholesterol2.19975155
24MP0003763_abnormal_thymus_physiology2.17036119
25MP0003828_pulmonary_edema2.09295659
26MP0002405_respiratory_system_inflammati2.08171637
27MP0008260_abnormal_autophagy1.97289657
28MP0004947_skin_inflammation1.90570789
29MP0005451_abnormal_body_composition1.85515477
30MP0002398_abnormal_bone_marrow1.77114899
31MP0004510_myositis1.76904492
32MP0000716_abnormal_immune_system1.75676951
33MP0010155_abnormal_intestine_physiology1.71128763
34MP0009764_decreased_sensitivity_to1.70550688
35MP0001845_abnormal_inflammatory_respons1.68437639
36MP0005464_abnormal_platelet_physiology1.67227004
37MP0009333_abnormal_splenocyte_physiolog1.55835561
38MP0000858_altered_metastatic_potential1.52291516
39MP0000689_abnormal_spleen_morphology1.47651802
40MP0005397_hematopoietic_system_phenotyp1.45928398
41MP0001545_abnormal_hematopoietic_system1.45928398
42MP0002722_abnormal_immune_system1.44297548
43MP0002998_abnormal_bone_remodeling1.42807831
44MP0004883_abnormal_blood_vessel1.42731732
45MP0008469_abnormal_protein_level1.40173143
46MP0009278_abnormal_bone_marrow1.38696477
47MP0002132_abnormal_respiratory_system1.37744080
48MP0003866_abnormal_defecation1.36486981
49MP0002429_abnormal_blood_cell1.35346701
50MP0005164_abnormal_response_to1.33342869
51MP0005058_abnormal_lysosome_morphology1.32517882
52MP0001851_eye_inflammation1.30970462
53MP0000703_abnormal_thymus_morphology1.29972029
54MP0002396_abnormal_hematopoietic_system1.29945418
55MP0001853_heart_inflammation1.27961048
56MP0003279_aneurysm1.26896215
57MP0000465_gastrointestinal_hemorrhage1.25889522
58MP0005310_abnormal_salivary_gland1.21794612
59MP0003656_abnormal_erythrocyte_physiolo1.19925398
60MP0003448_altered_tumor_morphology1.19067780
61MP0000604_amyloidosis1.17854886
62MP0002933_joint_inflammation1.17317343
63MP0002166_altered_tumor_susceptibility1.12509679
64MP0000015_abnormal_ear_pigmentation1.12145627
65MP0003091_abnormal_cell_migration1.11396610
66MP0003075_altered_response_to1.10584545
67MP0003183_abnormal_peptide_metabolism1.05313525
68MP0005390_skeleton_phenotype1.04769927
69MP0006054_spinal_hemorrhage1.00153389
70MP0008004_abnormal_stomach_pH0.99426141
71MP0000343_altered_response_to0.98769597
72MP0004808_abnormal_hematopoietic_stem0.98310283
73MP0002332_abnormal_exercise_endurance0.98277629
74MP0003690_abnormal_glial_cell0.96761082
75MP0005166_decreased_susceptibility_to0.95665882
76MP0010368_abnormal_lymphatic_system0.94362752
77MP0003221_abnormal_cardiomyocyte_apopto0.92072411
78MP0004381_abnormal_hair_follicle0.90044695
79MP0002277_abnormal_respiratory_mucosa0.89855702
80MP0003329_amyloid_beta_deposits0.88777595
81MP0008438_abnormal_cutaneous_collagen0.88349980
82MP0001958_emphysema0.87740939
83MP0000767_abnormal_smooth_muscle0.86521032
84MP0003795_abnormal_bone_structure0.82818226
85MP0003566_abnormal_cell_adhesion0.81255731
86MP0002006_tumorigenesis0.78704740
87MP0009763_increased_sensitivity_to0.78646903
88MP0000249_abnormal_blood_vessel0.78323540
89MP0003045_fibrosis0.74422253
90MP0001542_abnormal_bone_strength0.71995242
91MP0005409_darkened_coat_color0.71014870
92MP0001663_abnormal_digestive_system0.69318008
93MP0003705_abnormal_hypodermis_morpholog0.68821026
94MP0002009_preneoplasia0.67817730
95MP0009765_abnormal_xenobiotic_induced0.61156309
96MP0005388_respiratory_system_phenotype0.60768806
97MP0002133_abnormal_respiratory_system0.60768806
98MP0009840_abnormal_foam_cell0.60666562
99MP0008874_decreased_physiological_sensi0.57407034
100MP0002928_abnormal_bile_duct0.55786455

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.79623458
2Myositis (HP:0100614)5.30775818
3Orchitis (HP:0100796)5.08993889
4Recurrent bacterial skin infections (HP:0005406)4.94815454
5Recurrent abscess formation (HP:0002722)4.83781192
6Abnormality of macrophages (HP:0004311)4.80134699
7Optic neuritis (HP:0100653)4.77945222
8Retrobulbar optic neuritis (HP:0100654)4.77945222
9Gastrointestinal infarctions (HP:0005244)4.56522839
10Elevated erythrocyte sedimentation rate (HP:0003565)4.32641828
11Stomatitis (HP:0010280)4.25336833
12Peritonitis (HP:0002586)4.10983014
13Recurrent gram-negative bacterial infections (HP:0005420)3.97563989
14Mediastinal lymphadenopathy (HP:0100721)3.87633852
15Abnormal delayed hypersensitivity skin test (HP:0002963)3.86616144
16Recurrent fungal infections (HP:0002841)3.73255934
17Vasculitis (HP:0002633)3.43737083
18Recurrent skin infections (HP:0001581)3.43538861
19Recurrent cutaneous fungal infections (HP:0011370)3.37119543
20Chronic mucocutaneous candidiasis (HP:0002728)3.37119543
21Keratoconjunctivitis sicca (HP:0001097)3.29303064
22Meningitis (HP:0001287)3.29033283
23Obstructive lung disease (HP:0006536)3.27612024
24Chronic obstructive pulmonary disease (HP:0006510)3.27612024
25Encephalitis (HP:0002383)3.24899387
26Spontaneous hematomas (HP:0007420)3.19641130
27Abnormality of T cell number (HP:0011839)3.09560639
28Increased IgM level (HP:0003496)3.09531729
29T lymphocytopenia (HP:0005403)3.07445317
30Chest pain (HP:0100749)3.07202129
31Gingivitis (HP:0000230)3.01828960
32Keratoconjunctivitis (HP:0001096)2.97141229
33Pulmonary infiltrates (HP:0002113)2.96852396
34Episodic fever (HP:0001954)2.88335063
35Abnormality of the peritoneum (HP:0002585)2.87688094
36Leukocytosis (HP:0001974)2.84561180
37Increased IgE level (HP:0003212)2.82942498
38Hemoptysis (HP:0002105)2.82689190
39Urticaria (HP:0001025)2.79347891
40Gingival bleeding (HP:0000225)2.72801212
41Arterial thrombosis (HP:0004420)2.72778801
42Cellulitis (HP:0100658)2.72174246
43Recurrent viral infections (HP:0004429)2.56465729
44Amyloidosis (HP:0011034)2.47398576
45Abnormality of T cells (HP:0002843)2.47286068
46Pulmonary embolism (HP:0002204)2.46988470
47Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.44978088
48Prolonged bleeding time (HP:0003010)2.43951392
49Epistaxis (HP:0000421)2.39421498
50Granulocytopenia (HP:0001913)2.37386446
51Hypochromic anemia (HP:0001931)2.37214431
52Hypergammaglobulinemia (HP:0010702)2.34871983
53Hypochromic microcytic anemia (HP:0004840)2.34784741
54Inflammation of the large intestine (HP:0002037)2.34627806
55Pustule (HP:0200039)2.29848271
56Gastrointestinal inflammation (HP:0004386)2.29563290
57Anorexia (HP:0002039)2.27497066
58Abnormality of glycolipid metabolism (HP:0010969)2.23531911
59Abnormality of liposaccharide metabolism (HP:0010968)2.23531911
60Abnormality of glycosphingolipid metabolism (HP:0004343)2.23531911
61Acute hepatic failure (HP:0006554)2.22639944
62Abnormality of the pleura (HP:0002103)2.21482409
63Panhypogammaglobulinemia (HP:0003139)2.21274823
64Glomerulopathy (HP:0100820)2.20248473
65Lymphopenia (HP:0001888)2.16599409
66Abnormality of cells of the lymphoid lineage (HP:0012140)2.13162682
67Autoimmune thrombocytopenia (HP:0001973)2.12981111
68Eosinophilia (HP:0001880)2.11942219
69Keratitis (HP:0000491)2.11263619
70Loss of speech (HP:0002371)2.10970739
71Colitis (HP:0002583)2.10177924
72Gangrene (HP:0100758)2.09581829
73Abnormality of T cell physiology (HP:0011840)2.06962491
74Abnormality of the endocardium (HP:0004306)2.03648123
75Recurrent bronchitis (HP:0002837)2.02088355
76Dysostosis multiplex (HP:0000943)2.01372337
77Dilatation of the ascending aorta (HP:0005111)1.99264732
78Sepsis (HP:0100806)1.97806904
79Osteomyelitis (HP:0002754)1.97159832
80Abnormality of the pericardium (HP:0001697)1.96392040
81Interstitial pulmonary disease (HP:0006530)1.93927206
82Myocardial infarction (HP:0001658)1.92120319
83Agammaglobulinemia (HP:0004432)1.89849119
84Viral hepatitis (HP:0006562)1.89644412
85Abnormality of eosinophils (HP:0001879)1.88309861
86Hematochezia (HP:0002573)1.85581178
87Skin ulcer (HP:0200042)1.84717982
88Vertigo (HP:0002321)1.84673207
89Abnormality of polysaccharide metabolism (HP:0011012)1.82658341
90Abnormality of glycosaminoglycan metabolism (HP:0004371)1.82658341
91Abnormality of mucopolysaccharide metabolism (HP:0011020)1.82658341
92Joint swelling (HP:0001386)1.82000631
93Gastrointestinal stroma tumor (HP:0100723)1.79851394
94Autoimmune hemolytic anemia (HP:0001890)1.79715364
95Hepatosplenomegaly (HP:0001433)1.79147221
96Amaurosis fugax (HP:0100576)1.79091509
97Subacute progressive viral hepatitis (HP:0006572)1.78831929
98Systemic lupus erythematosus (HP:0002725)1.78776509
99Papilledema (HP:0001085)1.78702702
100Choroideremia (HP:0001139)1.76523076

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK43.67111765
2MAP4K13.32603092
3TYK22.93564672
4PRPF4B2.74779830
5BLK2.71310429
6ERN12.60064938
7IRAK42.52231851
8CSK2.41884210
9MAP3K142.41064187
10MAP2K32.34838691
11MAP3K132.25839070
12JAK32.13627982
13TXK2.09743982
14SIK32.03254531
15ZAP701.97537254
16IKBKE1.93327809
17EPHB11.86950022
18FES1.84573475
19GRK61.80940491
20MAP3K31.76833932
21TBK11.76055802
22TNK21.73417514
23JAK11.69343656
24FGR1.58180052
25SIK21.52980516
26HCK1.48730162
27TAOK11.37449969
28BTK1.36310754
29JAK21.32290626
30SYK1.31682281
31MAP3K111.31333487
32RIPK11.29135829
33PRKD21.26870149
34TGFBR21.17302742
35LCK1.17027937
36KSR21.15348270
37TAOK31.11532264
38LYN1.11408405
39TEC1.10092031
40MAP3K11.09666411
41KIT1.09138432
42FGFR41.08566287
43IKBKB1.08331813
44GRK71.07231433
45MATK1.06093220
46CSF1R1.05866606
47MARK21.05661641
48ITK1.01285462
49IRAK31.00596166
50BMPR21.00443516
51CDC42BPA0.99725552
52TAOK20.96077963
53STK100.95603870
54DYRK1B0.93385456
55MARK30.92019178
56MAP3K70.91890708
57CAMKK20.82778694
58FGFR30.81883399
59TESK20.78111148
60YES10.77214540
61PDK10.73681124
62STK380.73014110
63IRAK10.68829502
64TIE10.68589819
65IRAK20.66670870
66FYN0.66479319
67PTK60.66077195
68CDK120.63920636
69SIK10.61849537
70PRKCQ0.60815107
71MOS0.60397501
72MAPK70.59918167
73HIPK20.58885673
74PDPK10.58695384
75TRIB30.57716243
76MAP3K50.55650072
77PTK2B0.54355297
78KSR10.48946836
79RAF10.47544359
80MAPK120.46950901
81MAP3K60.44605648
82EPHA30.43829864
83DYRK30.43034125
84PDGFRB0.40931943
85CHUK0.40885455
86PRKG20.40455281
87SGK30.39913575
88CAMKK10.39644965
89RPS6KC10.39127332
90RPS6KL10.39127332
91BRD40.38961855
92RET0.38106942
93DDR20.37853529
94MAPKAPK20.37750930
95PIK3CG0.37307356
96PIM10.37234590
97BCR0.32112759
98LRRK20.32103937
99MAP2K60.32053566
100STK160.31708328

Predicted pathways (KEGG)

RankGene SetZ-score
1Osteoclast differentiation_Homo sapiens_hsa043802.70809942
2Leishmaniasis_Homo sapiens_hsa051402.66163372
3Toll-like receptor signaling pathway_Homo sapiens_hsa046202.15939562
4Staphylococcus aureus infection_Homo sapiens_hsa051502.08319294
5Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.06082764
6Graft-versus-host disease_Homo sapiens_hsa053322.02589522
7NOD-like receptor signaling pathway_Homo sapiens_hsa046211.97115262
8Tuberculosis_Homo sapiens_hsa051521.95659264
9NF-kappa B signaling pathway_Homo sapiens_hsa040641.94929567
10Allograft rejection_Homo sapiens_hsa053301.93844581
11Primary immunodeficiency_Homo sapiens_hsa053401.92240580
12B cell receptor signaling pathway_Homo sapiens_hsa046621.92129777
13RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.90636713
14Measles_Homo sapiens_hsa051621.82464525
15TNF signaling pathway_Homo sapiens_hsa046681.80662127
16Autoimmune thyroid disease_Homo sapiens_hsa053201.74321820
17T cell receptor signaling pathway_Homo sapiens_hsa046601.70376872
18Malaria_Homo sapiens_hsa051441.69543465
19Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.69514985
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.66571023
21Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.62186595
22Other glycan degradation_Homo sapiens_hsa005111.62166922
23Toxoplasmosis_Homo sapiens_hsa051451.56394779
24Chemokine signaling pathway_Homo sapiens_hsa040621.54777466
25Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.54481024
26Acute myeloid leukemia_Homo sapiens_hsa052211.49521510
27Influenza A_Homo sapiens_hsa051641.49227436
28Antigen processing and presentation_Homo sapiens_hsa046121.48210650
29Hematopoietic cell lineage_Homo sapiens_hsa046401.44601385
30Herpes simplex infection_Homo sapiens_hsa051681.40257641
31Legionellosis_Homo sapiens_hsa051341.40149412
32Phagosome_Homo sapiens_hsa041451.38910411
33Jak-STAT signaling pathway_Homo sapiens_hsa046301.38489516
34African trypanosomiasis_Homo sapiens_hsa051431.38395149
35Viral myocarditis_Homo sapiens_hsa054161.35703220
36Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.35467201
37Hepatitis B_Homo sapiens_hsa051611.32125241
38Type I diabetes mellitus_Homo sapiens_hsa049401.30904170
39Salmonella infection_Homo sapiens_hsa051321.30016675
40Shigellosis_Homo sapiens_hsa051311.28683612
41Pertussis_Homo sapiens_hsa051331.27825664
42Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.24884224
43Rheumatoid arthritis_Homo sapiens_hsa053231.21821101
44Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.15994412
45AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.15357838
46Hepatitis C_Homo sapiens_hsa051601.14971101
47Leukocyte transendothelial migration_Homo sapiens_hsa046701.11942871
48Non-small cell lung cancer_Homo sapiens_hsa052231.11588284
49Intestinal immune network for IgA production_Homo sapiens_hsa046721.08846566
50Chronic myeloid leukemia_Homo sapiens_hsa052201.07197536
51Lysosome_Homo sapiens_hsa041421.01332038
52Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.00777391
53Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.00234761
54Pancreatic cancer_Homo sapiens_hsa052120.97072397
55Apoptosis_Homo sapiens_hsa042100.96224040
56Glycosaminoglycan degradation_Homo sapiens_hsa005310.91308003
57Prolactin signaling pathway_Homo sapiens_hsa049170.89977781
58Platelet activation_Homo sapiens_hsa046110.89927643
59Neurotrophin signaling pathway_Homo sapiens_hsa047220.89904153
60Endocytosis_Homo sapiens_hsa041440.88207979
61Notch signaling pathway_Homo sapiens_hsa043300.85494432
62VEGF signaling pathway_Homo sapiens_hsa043700.84617557
63SNARE interactions in vesicular transport_Homo sapiens_hsa041300.82496614
64Adipocytokine signaling pathway_Homo sapiens_hsa049200.80164561
65Asthma_Homo sapiens_hsa053100.79495418
66Amoebiasis_Homo sapiens_hsa051460.79180535
67Sphingolipid signaling pathway_Homo sapiens_hsa040710.74743285
68Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.71440972
69Renal cell carcinoma_Homo sapiens_hsa052110.70870162
70FoxO signaling pathway_Homo sapiens_hsa040680.70496303
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.68899969
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.68596935
73Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64528539
74Phosphatidylinositol signaling system_Homo sapiens_hsa040700.64424514
75GnRH signaling pathway_Homo sapiens_hsa049120.63989479
76Epstein-Barr virus infection_Homo sapiens_hsa051690.60010671
77Dorso-ventral axis formation_Homo sapiens_hsa043200.58679502
78Choline metabolism in cancer_Homo sapiens_hsa052310.58194043
79mTOR signaling pathway_Homo sapiens_hsa041500.57075972
80Inositol phosphate metabolism_Homo sapiens_hsa005620.55347587
81MAPK signaling pathway_Homo sapiens_hsa040100.55130977
82Endometrial cancer_Homo sapiens_hsa052130.54372638
83HIF-1 signaling pathway_Homo sapiens_hsa040660.53253076
84HTLV-I infection_Homo sapiens_hsa051660.52466084
85Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51897143
86Rap1 signaling pathway_Homo sapiens_hsa040150.51346807
87ErbB signaling pathway_Homo sapiens_hsa040120.51197129
88Bladder cancer_Homo sapiens_hsa052190.49726185
89Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48912108
90Insulin resistance_Homo sapiens_hsa049310.48291359
91Transcriptional misregulation in cancer_Homo sapiens_hsa052020.47924101
92Viral carcinogenesis_Homo sapiens_hsa052030.46858476
93Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46544819
94Proteoglycans in cancer_Homo sapiens_hsa052050.44784002
95Estrogen signaling pathway_Homo sapiens_hsa049150.41631679
96Colorectal cancer_Homo sapiens_hsa052100.38761493
97Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38748649
98Prostate cancer_Homo sapiens_hsa052150.38080557
99Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.36849754
100Focal adhesion_Homo sapiens_hsa045100.35676902

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »