BTN1A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Butyrophilin is the major protein associated with fat droplets in the milk. It is a member of the immunoglobulin superfamily. It may have a cell surface receptor function. The human butyrophilin gene is localized in the major histocompatibility complex (MHC) class I region of 6p and may have arisen relatively recently in evolution by the shuffling of exons between 2 ancestral gene families NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pattern specification involved in kidney development (GO:0061004)9.85811910
2intestinal cholesterol absorption (GO:0030299)8.41813583
3pyrimidine-containing compound transmembrane transport (GO:0072531)8.09979753
4regulation of vascular endothelial growth factor signaling pathway (GO:1900746)7.78892092
5fatty-acyl-CoA biosynthetic process (GO:0046949)7.69154858
6long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)7.55492797
7acyl-CoA biosynthetic process (GO:0071616)7.36934084
8thioester biosynthetic process (GO:0035384)7.36934084
9regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)7.23531040
10lactation (GO:0007595)7.13898284
11alpha-linolenic acid metabolic process (GO:0036109)6.84764401
12regulation of sequestering of triglyceride (GO:0010889)6.69553959
13negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)6.57385187
14sterol catabolic process (GO:0016127)6.56696311
15cholesterol catabolic process (GO:0006707)6.56696311
16linoleic acid metabolic process (GO:0043651)6.51677445
17positive regulation of p38MAPK cascade (GO:1900745)6.47168999
18mammary gland epithelial cell differentiation (GO:0060644)6.40946464
19regulation of phospholipid biosynthetic process (GO:0071071)6.31169315
20phospholipid homeostasis (GO:0055091)6.22931540
21nucleoside transmembrane transport (GO:1901642)6.03877954
22ectoderm development (GO:0007398)6.03753156
23secretion by tissue (GO:0032941)5.91472306
24carnitine shuttle (GO:0006853)5.88139461
25intestinal absorption (GO:0050892)5.83513121
26fatty acid transmembrane transport (GO:1902001)5.81146730
27long-chain fatty-acyl-CoA metabolic process (GO:0035336)5.78358412
28biotin metabolic process (GO:0006768)5.54216176
29fatty-acyl-CoA metabolic process (GO:0035337)5.42126862
30ceramide catabolic process (GO:0046514)5.30371346
31negative regulation of protein kinase B signaling (GO:0051898)5.22496453
32segment specification (GO:0007379)5.19984352
33N-acetylneuraminate metabolic process (GO:0006054)5.06608768
34mitochondrial calcium ion transport (GO:0006851)4.99263198
35body fluid secretion (GO:0007589)4.92361271
36tooth mineralization (GO:0034505)4.91197126
37positive regulation of osteoblast proliferation (GO:0033690)4.84569065
38O-glycan processing (GO:0016266)4.78831356
39embryonic process involved in female pregnancy (GO:0060136)4.77619984
40regulation of acrosome reaction (GO:0060046)4.68783851
41nucleobase catabolic process (GO:0046113)4.61851376
42negative regulation of endothelial cell proliferation (GO:0001937)4.61739035
43nucleoside transport (GO:0015858)4.61009764
44regulation of apoptotic process involved in morphogenesis (GO:1902337)4.58740908
45acetyl-CoA metabolic process (GO:0006084)4.50640169
46GDP-mannose metabolic process (GO:0019673)4.49064482
47folic acid transport (GO:0015884)4.48460505
48regulation of p38MAPK cascade (GO:1900744)4.40421956
49positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.33428457
50regulation of penile erection (GO:0060405)4.33389977
51growth hormone receptor signaling pathway (GO:0060396)4.33169822
52carnitine transmembrane transport (GO:1902603)4.32538359
53triglyceride biosynthetic process (GO:0019432)4.31066940
54phagocytosis, recognition (GO:0006910)4.28682339
55regulation of apoptotic cell clearance (GO:2000425)4.28328987
56acylglycerol biosynthetic process (GO:0046463)4.17294613
57neutral lipid biosynthetic process (GO:0046460)4.17294613
58negative regulation of keratinocyte proliferation (GO:0010839)4.16584315
59response to host immune response (GO:0052572)4.11347018
60response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.11347018
61lipid storage (GO:0019915)4.07942098
62coenzyme A biosynthetic process (GO:0015937)4.03086967
63tricarboxylic acid metabolic process (GO:0072350)3.99296073
64regulation of toll-like receptor 4 signaling pathway (GO:0034143)3.98516343
65response to phenylpropanoid (GO:0080184)3.97961199
66CDP-diacylglycerol biosynthetic process (GO:0016024)3.95280625
67copper ion transport (GO:0006825)3.92770284
68long-chain fatty acid transport (GO:0015909)3.92554310
69amino-acid betaine transport (GO:0015838)3.90512107
70carnitine transport (GO:0015879)3.90512107
71regulation of triglyceride biosynthetic process (GO:0010866)3.89738378
72Golgi transport vesicle coating (GO:0048200)3.85492108
73COPI coating of Golgi vesicle (GO:0048205)3.85492108
74positive regulation of reactive oxygen species metabolic process (GO:2000379)3.83410528
75positive regulation of macrophage cytokine production (GO:0060907)3.82682953
76CDP-diacylglycerol metabolic process (GO:0046341)3.77684195
77negative regulation of epithelial cell differentiation (GO:0030857)3.76473463
78regulation of triglyceride metabolic process (GO:0090207)3.76472235
79nucleotide-sugar biosynthetic process (GO:0009226)3.73500704
80positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.71392476
81negative regulation of lipid catabolic process (GO:0050995)3.71192980
82regulation of endothelial cell differentiation (GO:0045601)3.70072238
83glutathione biosynthetic process (GO:0006750)3.69407924
84oligosaccharide metabolic process (GO:0009311)3.66730202
85response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.64803383
86response to host (GO:0075136)3.64803383
87response to host defenses (GO:0052200)3.64803383
88cellular response to growth hormone stimulus (GO:0071378)3.62514278
89intracellular lipid transport (GO:0032365)3.62494110
90negative regulation of fatty acid transport (GO:2000192)3.62168562
91regulation of macrophage cytokine production (GO:0010935)3.58331360
92positive regulation of toll-like receptor signaling pathway (GO:0034123)3.57593604
93zinc ion transport (GO:0006829)3.55033777
94negative regulation of execution phase of apoptosis (GO:1900118)3.53577001
95galactose metabolic process (GO:0006012)3.52843467
96regulation of vasculogenesis (GO:2001212)3.52324390
97positive regulation of triglyceride metabolic process (GO:0090208)3.51743142
98fatty acid transport (GO:0015908)3.51700088
99cellular carbohydrate biosynthetic process (GO:0034637)3.48490900
100nonribosomal peptide biosynthetic process (GO:0019184)3.48018273
101regulation of clathrin-mediated endocytosis (GO:2000369)3.46463803
102regulation of execution phase of apoptosis (GO:1900117)3.41860115
103detection of molecule of bacterial origin (GO:0032490)3.38464646
104angiogenesis involved in wound healing (GO:0060055)3.36748763
105proximal/distal pattern formation (GO:0009954)3.36557473
106transcytosis (GO:0045056)3.30860033
107purine nucleobase metabolic process (GO:0006144)3.28469091
108positive regulation of chemokine secretion (GO:0090197)3.24907647
109low-density lipoprotein particle clearance (GO:0034383)3.24003840
110negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)3.21938832
111positive regulation of lipid storage (GO:0010884)3.20948930
112positive regulation of tissue remodeling (GO:0034105)3.19790092
113valine metabolic process (GO:0006573)3.19720119
114mitochondrion distribution (GO:0048311)3.19039876
115sphingolipid catabolic process (GO:0030149)3.18842287
116positive regulation of histone deacetylation (GO:0031065)3.17562517
117branched-chain amino acid metabolic process (GO:0009081)3.15335714
118temperature homeostasis (GO:0001659)3.14226767
119protein O-linked glycosylation (GO:0006493)3.12653293
120regulation of cholesterol storage (GO:0010885)3.12159638
121hemidesmosome assembly (GO:0031581)3.11479144
122sialylation (GO:0097503)3.09780638
123mammary gland development (GO:0030879)3.08527202
124cellular response to vitamin D (GO:0071305)3.08025290
125thioester metabolic process (GO:0035383)3.06816238
126acyl-CoA metabolic process (GO:0006637)3.06816238
127branched-chain amino acid catabolic process (GO:0009083)3.05619788
128purine nucleoside bisphosphate biosynthetic process (GO:0034033)3.02297241
129ribonucleoside bisphosphate biosynthetic process (GO:0034030)3.02297241
130nucleoside bisphosphate biosynthetic process (GO:0033866)3.02297241
131urate metabolic process (GO:0046415)3.02224532
132regulation of fatty acid oxidation (GO:0046320)2.99798481
133regulation of chemokine secretion (GO:0090196)2.98476335
134steroid catabolic process (GO:0006706)2.96153120
135heme transport (GO:0015886)2.95556139
136regulation of triglyceride catabolic process (GO:0010896)2.95527140
137positive regulation of triglyceride lipase activity (GO:0061365)2.94687957
138positive regulation of lipoprotein lipase activity (GO:0051006)2.94687957
139regulation of lipid storage (GO:0010883)2.94143683
140insulin-like growth factor receptor signaling pathway (GO:0048009)2.92855493
141coenzyme A metabolic process (GO:0015936)2.92055528
142regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.90598420
143regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.90598420
144iron ion import (GO:0097286)2.90379931
145positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.88534571
146type B pancreatic cell proliferation (GO:0044342)2.87996508
147membrane lipid catabolic process (GO:0046466)2.83735587
148acrosome assembly (GO:0001675)2.80355922
149short-chain fatty acid metabolic process (GO:0046459)2.79152179
150negative regulation of cell fate commitment (GO:0010454)2.78561302
151detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)2.77941306
152regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)2.65729466
153nucleoside diphosphate biosynthetic process (GO:0009133)2.65443602
154negative regulation of transcription by competitive promoter binding (GO:0010944)2.52464414
155peptide biosynthetic process (GO:0043043)2.50943725
156negative regulation of leukocyte migration (GO:0002686)2.49651683
157digestive system process (GO:0022600)2.48103825
158detection of chemical stimulus involved in sensory perception of taste (GO:0050912)2.45811243
159triglyceride metabolic process (GO:0006641)2.43274100
160citrulline biosynthetic process (GO:0019240)2.42742434
161pantothenate metabolic process (GO:0015939)2.42660422
162oligosaccharide biosynthetic process (GO:0009312)12.4606204

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse7.86015121
2ESR1_21235772_ChIP-Seq_MCF-7_Human5.58383116
3TP63_17297297_ChIP-ChIP_HaCaT_Human5.05858301
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.80787962
5ESR2_21235772_ChIP-Seq_MCF-7_Human4.11220803
6STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.56967735
7PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.28207665
8IRF8_21731497_ChIP-ChIP_J774_Mouse3.07761782
9CLOCK_20551151_ChIP-Seq_293T_Human2.94758011
10AR_21572438_ChIP-Seq_LNCaP_Human2.74452800
11ZNF217_24962896_ChIP-Seq_MCF-7_Human2.51269957
12SRY_22984422_ChIP-ChIP_TESTIS_Rat2.18907877
13TRIM28_21343339_ChIP-Seq_HEK293_Human2.18205439
14ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.18026994
15ZNF263_19887448_ChIP-Seq_K562_Human2.02695429
16TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.00163360
17PPAR_26484153_Chip-Seq_NCI-H1993_Human1.98721144
18FOXO3_23340844_ChIP-Seq_DLD1_Human1.97666527
19SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.97506297
20TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.96206764
21RXR_22108803_ChIP-Seq_LS180_Human1.95226059
22ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.87806762
23ESR1_15608294_ChIP-ChIP_MCF-7_Human1.83979012
24EGR1_23403033_ChIP-Seq_LIVER_Mouse1.80233417
25RXR_22158963_ChIP-Seq_LIVER_Mouse1.79945561
26NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.76283390
27PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.75869262
28SOX2_20726797_ChIP-Seq_SW620_Human1.74503814
29LXR_22158963_ChIP-Seq_LIVER_Mouse1.71143420
30CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.70998631
31ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.68774632
32FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.59805413
33SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.59802736
34HTT_18923047_ChIP-ChIP_STHdh_Human1.58894039
35TCF3_18692474_ChIP-Seq_MEFs_Mouse1.58316294
36LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.53607602
37ESR1_20079471_ChIP-ChIP_T-47D_Human1.52918528
38SOX9_24532713_ChIP-Seq_HFSC_Mouse1.50747979
39IRF8_27001747_Chip-Seq_BMDM_Mouse1.50364111
40* FLI1_21867929_ChIP-Seq_CD8_Mouse1.49733594
41STAT1_20625510_ChIP-Seq_HELA_Human1.49716482
42SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.46291373
43* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.45128535
44TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.44742130
45ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.43892352
46KLF5_25053715_ChIP-Seq_YYC3_Human1.43799376
47NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.41036948
48EP300_21415370_ChIP-Seq_HL-1_Mouse1.40672348
49* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.39314943
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.38392884
51LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.38199755
52ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.36217331
53STAT3_1855785_ChIP-Seq_MESCs_Mouse1.35931820
54PPARA_22158963_ChIP-Seq_LIVER_Mouse1.31873241
55SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.31755939
56GATA3_24758297_ChIP-Seq_MCF-7_Human1.30190255
57EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.29909624
58* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.29761269
59SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.29689763
60* GATA4_25053715_ChIP-Seq_YYC3_Human1.28035999
61* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.26794468
62GATA1_22025678_ChIP-Seq_K562_Human1.25743429
63POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.25742207
64PKCTHETA_26484144_Chip-Seq_BREAST_Human1.25453888
65GATA2_21666600_ChIP-Seq_HMVEC_Human1.24554277
66EGR1_19374776_ChIP-ChIP_THP-1_Human1.22233295
67RUNX1_27514584_Chip-Seq_MCF-7_Human1.22015604
68SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.21362691
69SOX2_27498859_Chip-Seq_STOMACH_Mouse1.19551514
70TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.18946678
71CJUN_26792858_Chip-Seq_BT549_Human1.17635445
72CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.17302996
73AHR_22903824_ChIP-Seq_MCF-7_Human1.16599128
74FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.16096380
75RUNX1_27457419_Chip-Seq_LIVER_Mouse1.15615993
76JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.14618568
77CTNNB1_20460455_ChIP-Seq_HCT116_Human1.12858596
78AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.12836565
79TP63_23658742_ChIP-Seq_EP156T_Human1.12607842
80PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.12549113
81SMC4_20622854_ChIP-Seq_HELA_Human1.12014324
82TP53_18474530_ChIP-ChIP_U2OS_Human1.11349480
83* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.11226124
84KAP1_22055183_ChIP-Seq_ESCs_Mouse1.11118345
85* CTCF_26484167_Chip-Seq_Bcells_Mouse1.10168065
86GATA1_22383799_ChIP-Seq_G1ME_Mouse1.09528414
87AR_25329375_ChIP-Seq_VCAP_Human1.08102463
88FOXM1_26456572_ChIP-Seq_MCF-7_Human1.07938700
89TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06189587
90TBX20_22328084_ChIP-Seq_HEART_Mouse1.05055145
91TBX20_22080862_ChIP-Seq_HEART_Mouse1.05055145
92KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.04915684
93POU3F2_20337985_ChIP-ChIP_501MEL_Human1.04764996
94ERG_21242973_ChIP-ChIP_JURKAT_Human1.04679381
95TP53_16413492_ChIP-PET_HCT116_Human1.04590926
96RACK7_27058665_Chip-Seq_MCF-7_Human1.04108904
97SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.01587502
98SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.01587502
99STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.01526605
100TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.01034001
101HIF1A_21447827_ChIP-Seq_MCF-7_Human1.00857170
102TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.99171187
103FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.98825599
104SMC1_22415368_ChIP-Seq_MEFs_Mouse0.98484469
105NANOG_21062744_ChIP-ChIP_HESCs_Human0.97588930
106PU1_27457419_Chip-Seq_LIVER_Mouse0.97202945
107FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97027341
108TDRD3_21172665_ChIP-Seq_MCF-7_Human0.96763389
109ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.95963773
110SA1_27219007_Chip-Seq_ERYTHROID_Human0.95259768
111GATA2_19941826_ChIP-Seq_K562_Human0.94490438
112NFYA_21822215_ChIP-Seq_K562_Human0.93399078
113TCF4_22108803_ChIP-Seq_LS180_Human0.93254208
114P63_26484246_Chip-Seq_KERATINOCYTES_Human0.92712177
115SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.91732040
116NRF2_20460467_ChIP-Seq_MEFs_Mouse0.91267566
117NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.91267566
118CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.91175610
119GATA1_19941826_ChIP-Seq_K562_Human0.90510177
120POU5F1_16518401_ChIP-PET_MESCs_Mouse0.90425586
121NANOG_18692474_ChIP-Seq_MEFs_Mouse0.90012884
122RBPJ_21746931_ChIP-Seq_IB4_Human0.89869725
123AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89722605
124SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.89262376
125RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.88697395
126MYB_21317192_ChIP-Seq_ERMYB_Mouse0.87542992
127CBP_21632823_ChIP-Seq_H3396_Human0.87046117
128CBX2_22325352_ChIP-Seq_293T-Rex_Human0.86900476
129PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.86771046
130CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86607471
131GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.86577951
132SALL4_18804426_ChIP-ChIP_XEN_Mouse0.86548345
133SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86191977
134PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86182723
135SOX2_18692474_ChIP-Seq_MEFs_Mouse0.85629989
136ERG_20517297_ChIP-Seq_VCAP_Human0.85603354
137BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.85545505
138* FOXA1_25552417_ChIP-Seq_VCAP_Human0.85367359
139GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.84838642
140CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.84165635
141STAT1_17558387_ChIP-Seq_HELA_Human0.84139782
142E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.83826923
143GATA2_22383799_ChIP-Seq_G1ME_Mouse0.83576863
144GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.81664764
145VDR_24787735_ChIP-Seq_THP-1_Human0.81285697
146GATA6_25053715_ChIP-Seq_YYC3_Human0.81061554
147NFIB_24661679_ChIP-Seq_LUNG_Mouse0.80781784
148* PU_27001747_Chip-Seq_BMDM_Mouse0.79703458
149FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.79598510
150ARNT_22903824_ChIP-Seq_MCF-7_Human0.79403709
151FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.79041519
152Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.78788943
153SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.78696947
154CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.77969453
155NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.77911393
156CHD1_26751641_Chip-Seq_LNCaP_Human0.77435172
157TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.76781633

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle4.38850145
2MP0002254_reproductive_system_inflammat3.69921892
3MP0003300_gastrointestinal_ulcer3.41941655
4MP0003136_yellow_coat_color3.28221506
5* MP0000627_abnormal_mammary_gland3.27279978
6MP0005083_abnormal_biliary_tract3.21548823
7MP0003718_maternal_effect3.10096797
8MP0003303_peritoneal_inflammation2.86752355
9MP0001873_stomach_inflammation2.84971853
10MP0004147_increased_porphyrin_level2.84926304
11MP0004130_abnormal_muscle_cell2.69358062
12MP0003011_delayed_dark_adaptation2.58183240
13MP0004019_abnormal_vitamin_homeostasis2.55853055
14MP0004264_abnormal_extraembryonic_tissu2.48444079
15MP0002796_impaired_skin_barrier2.04641132
16* MP0001881_abnormal_mammary_gland12.0901797
17MP0003705_abnormal_hypodermis_morpholog1.98905601
18MP0005395_other_phenotype1.85116971
19MP0002098_abnormal_vibrissa_morphology1.70630252
20MP0005085_abnormal_gallbladder_physiolo1.68758306
21MP0004043_abnormal_pH_regulation1.68577540
22MP0002009_preneoplasia1.66387442
23MP0005666_abnormal_adipose_tissue1.66351596
24MP0005360_urolithiasis1.63883142
25MP0005410_abnormal_fertilization1.59735753
26MP0005670_abnormal_white_adipose1.59277348
27MP0005058_abnormal_lysosome_morphology1.38029892
28MP0001664_abnormal_digestion1.31483390
29MP0000678_abnormal_parathyroid_gland1.28809762
30MP0008004_abnormal_stomach_pH1.26942088
31MP0002118_abnormal_lipid_homeostasis1.26671629
32MP0000377_abnormal_hair_follicle1.25559515
33MP0005171_absent_coat_pigmentation1.24984354
34MP0001666_abnormal_nutrient_absorption1.21829178
35MP0005375_adipose_tissue_phenotype1.21800249
36MP0008260_abnormal_autophagy1.20251656
37MP0003566_abnormal_cell_adhesion1.18639315
38MP0005501_abnormal_skin_physiology1.18566012
39MP0010678_abnormal_skin_adnexa1.16936439
40MP0010329_abnormal_lipoprotein_level1.12628891
41MP0000490_abnormal_crypts_of1.11181430
42MP0003936_abnormal_reproductive_system1.10853472
43MP0009384_cardiac_valve_regurgitation1.08274650
44MP0004185_abnormal_adipocyte_glucose1.07775488
45MP0004272_abnormal_basement_membrane1.07711531
46MP0002396_abnormal_hematopoietic_system1.07647833
47MP0009764_decreased_sensitivity_to1.01319427
48MP0010352_gastrointestinal_tract_polyps1.00290171
49MP0002168_other_aberrant_phenotype0.97504312
50MP0003045_fibrosis0.96234520
51MP0001663_abnormal_digestive_system0.92980122
52MP0002896_abnormal_bone_mineralization0.90877373
53MP0005076_abnormal_cell_differentiation0.90053485
54MP0002971_abnormal_brown_adipose0.88484475
55MP0005448_abnormal_energy_balance0.88048984
56MP0005334_abnormal_fat_pad0.86692308
57MP0003656_abnormal_erythrocyte_physiolo0.85803524
58MP0009765_abnormal_xenobiotic_induced0.82470265
59MP0008438_abnormal_cutaneous_collagen0.81199698
60MP0003448_altered_tumor_morphology0.80954422
61MP0001849_ear_inflammation0.79661530
62MP0002970_abnormal_white_adipose0.79210871
63MP0001216_abnormal_epidermal_layer0.79172399
64MP0000639_abnormal_adrenal_gland0.78591686
65MP0001177_atelectasis0.77223814
66MP0005275_abnormal_skin_tensile0.76242995
67MP0009278_abnormal_bone_marrow0.74022443
68MP0005584_abnormal_enzyme/coenzyme_acti0.73005868
69MP0005381_digestive/alimentary_phenotyp0.72873013
70MP0001727_abnormal_embryo_implantation0.72307741
71MP0005535_abnormal_body_temperature0.72025909
72MP0005645_abnormal_hypothalamus_physiol0.71515483
73MP0005636_abnormal_mineral_homeostasis0.70476570
74MP0005220_abnormal_exocrine_pancreas0.70172756
75MP0009379_abnormal_foot_pigmentation0.69547711
76MP0002282_abnormal_trachea_morphology0.69229092
77MP0005365_abnormal_bile_salt0.68658570
78MP0003453_abnormal_keratinocyte_physiol0.67518573
79MP0001984_abnormal_olfaction0.67245842
80MP0000613_abnormal_salivary_gland0.65828266
81MP0003950_abnormal_plasma_membrane0.65645311
82MP0005023_abnormal_wound_healing0.65251255
83MP0000003_abnormal_adipose_tissue0.64671234
84MP0004924_abnormal_behavior0.64479120
85MP0005386_behavior/neurological_phenoty0.64479120
86MP0004947_skin_inflammation0.64442228
87MP0008770_decreased_survivor_rate0.64250441
88MP0000609_abnormal_liver_physiology0.63576202
89MP0001879_abnormal_lymphatic_vessel0.62056921
90MP0002060_abnormal_skin_morphology0.62007542
91MP0003787_abnormal_imprinting0.60791231
92MP0001851_eye_inflammation0.59036825
93MP0009931_abnormal_skin_appearance0.56222299
94MP0002139_abnormal_hepatobiliary_system0.55939547
95MP0000427_abnormal_hair_cycle0.55424362
96MP0003075_altered_response_to0.55197921
97MP0005164_abnormal_response_to0.53486565
98MP0002148_abnormal_hypersensitivity_rea0.53391345
99MP0005452_abnormal_adipose_tissue0.53385349
100MP0000858_altered_metastatic_potential0.53264138
101MP0003699_abnormal_female_reproductive0.52497299
102MP0005408_hypopigmentation0.52292536
103MP0002078_abnormal_glucose_homeostasis0.51067309
104MP0005332_abnormal_amino_acid0.50789452
105MP0004883_abnormal_blood_vessel0.50051336
106MP0003948_abnormal_gas_homeostasis0.49508863
107MP0004858_abnormal_nervous_system0.48462945
108MP0003953_abnormal_hormone_level0.47678049
109MP0001958_emphysema0.47203588
110MP0010771_integument_phenotype0.46842478
111MP0009763_increased_sensitivity_to0.46576037
112MP0001533_abnormal_skeleton_physiology0.46474072
113MP0005388_respiratory_system_phenotype0.46046992
114MP0002133_abnormal_respiratory_system0.46046992
115MP0003795_abnormal_bone_structure0.45988484
116MP0003959_abnormal_lean_body0.45506075
117MP0005165_increased_susceptibility_to0.44927543
118MP0009643_abnormal_urine_homeostasis0.44586117
119MP0000759_abnormal_skeletal_muscle0.43902559
120MP0001544_abnormal_cardiovascular_syste0.43661595
121MP0005385_cardiovascular_system_phenoty0.43661595
122MP0009642_abnormal_blood_homeostasis0.42490907
123MP0001765_abnormal_ion_homeostasis0.42370091
124MP0002332_abnormal_exercise_endurance0.41310474
125MP0000013_abnormal_adipose_tissue0.41200962
126MP0003690_abnormal_glial_cell0.40381882
127MP0002135_abnormal_kidney_morphology0.39647015
128MP0000579_abnormal_nail_morphology0.39574235
129MP0003172_abnormal_lysosome_physiology0.38132159
130MP0005451_abnormal_body_composition0.37343918
131MP0009785_altered_susceptibility_to0.34728773
132MP0008789_abnormal_olfactory_epithelium0.33776952
133MP0001756_abnormal_urination0.33669788
134MP0008874_decreased_physiological_sensi0.32860594
135MP0000371_diluted_coat_color0.32519138
136MP0004782_abnormal_surfactant_physiolog0.32425452
137MP0005319_abnormal_enzyme/_coenzyme0.28781342
138MP0003195_calcinosis0.28651157
139MP0005499_abnormal_olfactory_system0.28558600
140MP0005394_taste/olfaction_phenotype0.28558600
141MP0003984_embryonic_growth_retardation0.28116660
142MP0001764_abnormal_homeostasis0.28060011
143MP0001853_heart_inflammation0.27291859
144MP0009333_abnormal_splenocyte_physiolog0.26986000
145MP0002088_abnormal_embryonic_growth/wei0.26118954
146MP0001542_abnormal_bone_strength0.26058075
147MP0002419_abnormal_innate_immunity0.25862203
148MP0002693_abnormal_pancreas_physiology0.25629639
149MP0002089_abnormal_postnatal_growth/wei0.25088893
150MP0000598_abnormal_liver_morphology0.24066918

Predicted human phenotypes

RankGene SetZ-score
1Hyperactive renin-angiotensin system (HP:0000841)6.89603577
2Decreased circulating renin level (HP:0003351)6.66408211
3Abnormality of purine metabolism (HP:0004352)6.55396619
4Amelogenesis imperfecta (HP:0000705)6.52032588
5Congenital ichthyosiform erythroderma (HP:0007431)5.52190580
6Gout (HP:0001997)5.34465316
7Axonal loss (HP:0003447)5.23667228
8Tubulointerstitial nephritis (HP:0001970)4.77577954
9Thin bony cortex (HP:0002753)4.63922636
10Hypokalemic alkalosis (HP:0001949)4.48337826
11Overgrowth (HP:0001548)4.40414151
12Abnormality of calcium-phosphate metabolism (HP:0100530)4.34796322
13Ectropion (HP:0000656)4.24218488
14Pili torti (HP:0003777)4.09274652
15Epidermoid cyst (HP:0200040)4.08782146
16Hyperlipoproteinemia (HP:0010980)4.00036265
17Hyperkalemia (HP:0002153)3.99767449
18Abnormality of nucleobase metabolism (HP:0010932)3.98310870
19Right ventricular cardiomyopathy (HP:0011663)3.96438031
20Chronic bronchitis (HP:0004469)3.90515072
21Hydronephrosis (HP:0000126)3.85630457
22Curly hair (HP:0002212)3.83319787
23Metaphyseal dysplasia (HP:0100255)3.82073921
24Nephritis (HP:0000123)3.79602387
25Enlarged epiphyses (HP:0010580)3.78936843
26Hyperaldosteronism (HP:0000859)3.69080767
27Aortic aneurysm (HP:0004942)3.59718310
28Myocardial infarction (HP:0001658)3.59329678
29Abnormality of renal excretion (HP:0011036)3.53785325
30Subcapsular cataract (HP:0000523)3.47539010
31Stridor (HP:0010307)3.41471935
32Onycholysis (HP:0001806)3.28941009
33Abnormality of renal resorption (HP:0011038)3.22205199
34Tubulointerstitial fibrosis (HP:0005576)3.19910653
35Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.17139888
36Skin nodule (HP:0200036)3.17099402
37Hypotension (HP:0002615)3.16617912
38Atrophic scars (HP:0001075)3.13560221
39Protuberant abdomen (HP:0001538)3.12033049
40Hyponatremia (HP:0002902)3.11344943
41Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.11266625
42Neurodegeneration (HP:0002180)3.09624555
43Abnormality of renin-angiotensin system (HP:0000847)3.07666091
44Hypoplasia of dental enamel (HP:0006297)3.03236347
45Metaphyseal irregularity (HP:0003025)2.98040883
46Tubular atrophy (HP:0000092)2.95501566
47Xanthomatosis (HP:0000991)2.94610136
48Glomerulosclerosis (HP:0000096)2.93995428
49Abnormal tarsal ossification (HP:0008369)2.93387011
50Abnormal auditory evoked potentials (HP:0006958)2.88653913
51Abnormality of chloride homeostasis (HP:0011422)2.81198368
52Aplasia cutis congenita (HP:0001057)2.77053186
53Nausea (HP:0002018)2.76740993
54Milia (HP:0001056)2.76067521
55Turricephaly (HP:0000262)2.74436133
56Flat acetabular roof (HP:0003180)2.69885394
57Hypoplasia of the iris (HP:0007676)2.64241398
58Abnormality of the dental pulp (HP:0006479)2.61260467
59Aortic dissection (HP:0002647)2.60712254
60Delayed epiphyseal ossification (HP:0002663)2.59630228
61Bone cyst (HP:0012062)2.57965339
62Abnormality of dental color (HP:0011073)2.57114665
63Widely patent fontanelles and sutures (HP:0004492)2.55290528
64Cortical dysplasia (HP:0002539)2.54225708
65Premature skin wrinkling (HP:0100678)2.51660993
66Renal salt wasting (HP:0000127)2.50395494
67Asymmetry of the thorax (HP:0001555)2.50137467
68Adrenal overactivity (HP:0002717)2.50119935
69Abnormality of sodium homeostasis (HP:0010931)2.50081457
70Hyperuricemia (HP:0002149)2.47882848
71Increased purine levels (HP:0004368)2.47882848
72Biliary tract neoplasm (HP:0100574)2.44145435
73Epiphyseal dysplasia (HP:0002656)2.42147585
74Hyperparathyroidism (HP:0000843)2.35448825
75Rickets (HP:0002748)2.35248198
76Aneurysm (HP:0002617)2.32708061
77Enlarged penis (HP:0000040)2.31748920
78Abnormal hair laboratory examination (HP:0003328)2.30870411
79Cerebral aneurysm (HP:0004944)2.30143652
80White forelock (HP:0002211)2.30119509
81Insulin-resistant diabetes mellitus (HP:0000831)2.28517562
82Intrahepatic cholestasis (HP:0001406)2.27324987
83Premature loss of primary teeth (HP:0006323)2.21737167
84Wide cranial sutures (HP:0010537)2.21226804
85Abdominal distention (HP:0003270)2.20889574
86Poor eye contact (HP:0000817)2.19004170
87Alkalosis (HP:0001948)2.18473600
88Hepatosplenomegaly (HP:0001433)2.16567407
89Loss of speech (HP:0002371)2.14490482
90Tetraparesis (HP:0002273)2.14433592
91Autoamputation (HP:0001218)2.13782349
92Retrobulbar optic neuritis (HP:0100654)2.12350998
93Optic neuritis (HP:0100653)2.12350998
94Arterial tortuosity (HP:0005116)2.11119663
95Metabolic acidosis (HP:0001942)2.10172556
96Azoospermia (HP:0000027)2.06752027
97Osteolytic defects of the phalanges of the hand (HP:0009771)2.06226070
98Osteolytic defects of the hand bones (HP:0009699)2.06226070
99Abnormal epiphyseal ossification (HP:0010656)2.05609976
100Abnormality of transition element cation homeostasis (HP:0011030)2.04933391
101Elevated alkaline phosphatase (HP:0003155)2.04450140
102Hypercholesterolemia (HP:0003124)2.02307933
103Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.01921377
104Reduced antithrombin III activity (HP:0001976)2.00829609
105Glomerulonephritis (HP:0000099)2.00524513
106Buphthalmos (HP:0000557)2.00443284
107Abnormality of the anterior chamber (HP:0000593)1.99728591
108Patchy hypopigmentation of hair (HP:0011365)1.97538171
109Nephrolithiasis (HP:0000787)1.97349317
110Hypokalemia (HP:0002900)1.94669610
111Sparse lateral eyebrow (HP:0005338)1.94192810
112Orchitis (HP:0100796)1.94044334
113Abnormality of nail color (HP:0100643)1.94010623
114Polar cataract (HP:0010696)1.94007390
115Symptomatic seizures (HP:0011145)1.93265038
116Exostoses (HP:0100777)1.92881311
117Abnormality of the periventricular white matter (HP:0002518)1.91261549
118Vascular tortuosity (HP:0004948)1.91259075
119Vacuolated lymphocytes (HP:0001922)1.91232200
120Alopecia of scalp (HP:0002293)1.90825002
121Germ cell neoplasia (HP:0100728)1.90478886
122Pustule (HP:0200039)1.90005061
123Hypophosphatemia (HP:0002148)1.89474108
124Vascular calcification (HP:0004934)1.89066623
125Abnormality of the renal cortex (HP:0011035)1.86914438
126Hyperglycinuria (HP:0003108)1.86756437
127Paraparesis (HP:0002385)1.86499286
128Ketoacidosis (HP:0001993)1.86164118
129Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.85833559
130Abnormal enzyme/coenzyme activity (HP:0012379)1.85782510
131Cardiovascular calcification (HP:0011915)1.85650807
132Spastic tetraparesis (HP:0001285)1.85518013
133Macroorchidism (HP:0000053)1.83730370
134Pancreatitis (HP:0001733)1.81008338
135Erythroderma (HP:0001019)1.80418400
136Abnormality of alkaline phosphatase activity (HP:0004379)1.80060163
137Abnormality of the costochondral junction (HP:0000919)1.80037172
138Long toe (HP:0010511)1.79436563
139Abnormality of vision evoked potentials (HP:0000649)1.78594403
140Abnormality of glycine metabolism (HP:0010895)1.77287559
141Abnormality of serine family amino acid metabolism (HP:0010894)1.77287559
142Cortical visual impairment (HP:0100704)1.76994755
143Heterochromia iridis (HP:0001100)1.76084513
144Hypohidrosis (HP:0000966)1.75649877
145Hyperphosphatemia (HP:0002905)1.75627130
146Ketosis (HP:0001946)1.74801833
147Shallow orbits (HP:0000586)1.73100079
148Genu varum (HP:0002970)1.72852410
149Postnatal microcephaly (HP:0005484)1.72813595
150Epiphyseal stippling (HP:0010655)1.72247834
151Rough bone trabeculation (HP:0100670)1.71511953
152Impaired social interactions (HP:0000735)1.70372611
153Abnormal social behavior (HP:0012433)1.70372611
154Hyperglycinemia (HP:0002154)1.69892239
155Posterior subcapsular cataract (HP:0007787)1.68816561
156Abnormality of aromatic amino acid family metabolism (HP:0004338)1.66357725
157Abnormality of fatty-acid metabolism (HP:0004359)1.64281568
158Opisthotonus (HP:0002179)1.62284331
159Primary adrenal insufficiency (HP:0008207)1.61987389
160Congenital glaucoma (HP:0001087)1.61213443
161Asymmetric septal hypertrophy (HP:0001670)1.61103877
162Dysostosis multiplex (HP:0000943)1.60463624
163Spastic paraparesis (HP:0002313)1.60112920
164Flat occiput (HP:0005469)1.58091879
165Dehydration (HP:0001944)1.57831083
166Increased serum ferritin (HP:0003281)1.56393391
167Increased serum pyruvate (HP:0003542)1.56279456
168Tubulointerstitial abnormality (HP:0001969)1.53139804

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK16.64893840
2CAMK1D5.65258961
3CAMK1G4.40913015
4PKN24.33989963
5EEF2K3.29173681
6TRIB33.26328911
7ICK2.81657723
8MAP2K62.76598123
9LATS12.62547585
10PIK3CA2.56140128
11PDK42.47620273
12PDK32.47620273
13ARAF2.43059477
14NME22.41037229
15TESK12.27297718
16EPHA32.22605769
17PTK62.13670743
18ERN12.11328862
19STK38L2.10420288
20EPHB11.93935579
21PDGFRB1.84934486
22RIPK11.80085487
23PDK21.79614239
24MAP3K91.64703247
25BMPR21.63514645
26PRKAA21.60417777
27KSR21.52347206
28MAPKAPK31.49215148
29BCKDK1.47313483
30TESK21.40695632
31RET1.39240083
32ZAP701.37103747
33STK161.37099070
34TGFBR21.36838408
35SCYL21.36226910
36BRAF1.28238302
37MOS1.22532323
38MAP3K71.19384823
39STK381.18924214
40MAP3K131.18604932
41FER1.12926240
42TRPM71.11301538
43MAPKAPK51.09243869
44DAPK21.07405228
45FRK1.00587827
46RPS6KB20.98296905
47STK390.97915196
48RIPK40.96751451
49PINK10.94110158
50STK30.93916168
51CSNK2A20.87550137
52LRRK20.86546001
53BMX0.81842871
54PRKAA10.80810248
55EPHA20.71091674
56CAMK10.70366348
57JAK30.69692075
58IRAK40.69518089
59WNK40.66286367
60JAK10.64659698
61PRKCD0.64257370
62CAMK2D0.64060571
63GSK3A0.63967028
64CAMK2G0.61978959
65ILK0.61693704
66DDR20.61147266
67TAOK30.59479978
68IRAK30.58279349
69MAP2K20.57544864
70PTK20.57474207
71JAK20.57336424
72TAOK20.56929859
73SGK4940.55090625
74SGK2230.55090625
75LIMK10.54596533
76IRAK20.54198270
77MET0.53806171
78TAOK10.53244772
79IGF1R0.53211455
80EIF2AK10.52740424
81NEK90.52489998
82CDK60.51979299
83CHUK0.51931431
84MYLK0.51618776
85MATK0.51130244
86MAP3K20.49265249
87MAPK120.49000573
88CAMK2B0.48802545
89GRK60.48329561
90CSNK1A10.48218643
91MTOR0.47576170
92NLK0.47419846
93IKBKE0.47064949
94RPS6KA20.46982716
95PRKCG0.45941390
96FGFR40.44851312
97GRK70.44196243
98NEK60.43620312
99EIF2AK30.43505006
100EIF2AK20.42470827
101LMTK20.40184953
102PIM10.39134498
103RPS6KB10.38930187
104NUAK10.38903117
105FGFR30.38595094
106TBK10.37567318
107LATS20.37078318
108CDK90.37057153
109RAF10.36919746
110MAP2K10.35727500
111PIK3CG0.35212888
112CSF1R0.34100030
113TYK20.32839505
114PRKD20.31493253
115LYN0.30318939
116MAPK110.28564870
117MAP3K10.24722195
118PAK10.24648081
119MAP3K80.23781564
120SMG10.23454736
121PAK20.22962282
122PRKD10.22719005
123TIE10.22620454
124FLT30.22147661
125IRAK10.21571452
126MAP3K30.20361606
127PDGFRA0.19433149
128CASK0.19047346
129SRC0.18835341
130PRKCZ0.18733223
131MST1R0.17461123
132MARK30.17450833
133MAP3K60.17311930
134WNK10.15146157
135EGFR0.14859748
136PTK2B0.14467371
137MAP3K140.13701329
138PDK10.13066614
139PDPK10.12922923
140SGK30.12171105
141BCR0.12099509
142FGR0.10548397
143SGK20.09983818
144BTK0.09821809

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000619.43582523
2Caffeine metabolism_Homo sapiens_hsa002328.90097851
3Galactose metabolism_Homo sapiens_hsa000523.46816336
4Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.91236085
5Fatty acid metabolism_Homo sapiens_hsa012122.43435987
6Prolactin signaling pathway_Homo sapiens_hsa049172.28114675
7Propanoate metabolism_Homo sapiens_hsa006402.20429852
8Pyruvate metabolism_Homo sapiens_hsa006201.96142066
9Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.69916088
10Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.63291436
11PPAR signaling pathway_Homo sapiens_hsa033201.55266671
12Cyanoamino acid metabolism_Homo sapiens_hsa004601.47698938
13Nitrogen metabolism_Homo sapiens_hsa009101.43772489
14Steroid biosynthesis_Homo sapiens_hsa001001.30086771
15Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.16432683
16N-Glycan biosynthesis_Homo sapiens_hsa005101.11549115
17Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.02622869
18Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.00077064
19Fatty acid elongation_Homo sapiens_hsa000620.88342262
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.86177182
21Adipocytokine signaling pathway_Homo sapiens_hsa049200.84905861
22AMPK signaling pathway_Homo sapiens_hsa041520.84798410
23Insulin resistance_Homo sapiens_hsa049310.84237449
24Protein export_Homo sapiens_hsa030600.82081020
25Fatty acid degradation_Homo sapiens_hsa000710.73644191
26Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.72389216
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.69157915
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.66164080
29Pancreatic cancer_Homo sapiens_hsa052120.65462509
30Peroxisome_Homo sapiens_hsa041460.64218245
31Drug metabolism - other enzymes_Homo sapiens_hsa009830.61020815
32beta-Alanine metabolism_Homo sapiens_hsa004100.58909715
33Histidine metabolism_Homo sapiens_hsa003400.57640303
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.56449007
35Acute myeloid leukemia_Homo sapiens_hsa052210.54635996
36Amoebiasis_Homo sapiens_hsa051460.54235142
37Toxoplasmosis_Homo sapiens_hsa051450.52252994
38Carbon metabolism_Homo sapiens_hsa012000.50204754
39Fat digestion and absorption_Homo sapiens_hsa049750.49717167
40Glycerolipid metabolism_Homo sapiens_hsa005610.49574806
41Chronic myeloid leukemia_Homo sapiens_hsa052200.49356361
42ECM-receptor interaction_Homo sapiens_hsa045120.49102973
43Toll-like receptor signaling pathway_Homo sapiens_hsa046200.48112219
44Insulin signaling pathway_Homo sapiens_hsa049100.48037098
45Pentose phosphate pathway_Homo sapiens_hsa000300.47850394
46Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47227374
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.47138612
48Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.47126938
49Primary bile acid biosynthesis_Homo sapiens_hsa001200.44742132
50Small cell lung cancer_Homo sapiens_hsa052220.44285522
51Sulfur relay system_Homo sapiens_hsa041220.44110589
522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.43981615
53Hepatitis C_Homo sapiens_hsa051600.43920550
54mTOR signaling pathway_Homo sapiens_hsa041500.43715756
55AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.40992683
56Fructose and mannose metabolism_Homo sapiens_hsa000510.39856884
57Ether lipid metabolism_Homo sapiens_hsa005650.38612730
58Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36526516
59Folate biosynthesis_Homo sapiens_hsa007900.36023657
60Mineral absorption_Homo sapiens_hsa049780.35887931
61Intestinal immune network for IgA production_Homo sapiens_hsa046720.35790485
62Tight junction_Homo sapiens_hsa045300.35389812
63Rheumatoid arthritis_Homo sapiens_hsa053230.35079722
64Starch and sucrose metabolism_Homo sapiens_hsa005000.34431508
65Glucagon signaling pathway_Homo sapiens_hsa049220.34097181
66Vitamin digestion and absorption_Homo sapiens_hsa049770.33826357
67Focal adhesion_Homo sapiens_hsa045100.32255842
68Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.32245556
69Pancreatic secretion_Homo sapiens_hsa049720.29901691
70Adherens junction_Homo sapiens_hsa045200.29872287
71Colorectal cancer_Homo sapiens_hsa052100.29681239
72Bladder cancer_Homo sapiens_hsa052190.29323634
73Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.29192943
74Endometrial cancer_Homo sapiens_hsa052130.28862176
75Carbohydrate digestion and absorption_Homo sapiens_hsa049730.27484047
76Biosynthesis of amino acids_Homo sapiens_hsa012300.27360609
77alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27192047
78Arginine and proline metabolism_Homo sapiens_hsa003300.27109986
79Hepatitis B_Homo sapiens_hsa051610.26594161
80Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.26166218
81Purine metabolism_Homo sapiens_hsa002300.25947335
82Central carbon metabolism in cancer_Homo sapiens_hsa052300.25808205
83Proteoglycans in cancer_Homo sapiens_hsa052050.25656504
84Vibrio cholerae infection_Homo sapiens_hsa051100.25630606
85Sulfur metabolism_Homo sapiens_hsa009200.25373968
86Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.24842091
87FoxO signaling pathway_Homo sapiens_hsa040680.24570870
88Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.24315301
89HIF-1 signaling pathway_Homo sapiens_hsa040660.23829208
90Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.23733043
91Hippo signaling pathway_Homo sapiens_hsa043900.23611977
92SNARE interactions in vesicular transport_Homo sapiens_hsa041300.23447191
93Metabolic pathways_Homo sapiens_hsa011000.23087469
94Endocytosis_Homo sapiens_hsa041440.22855798
95Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.22417960
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.21944369
97Gastric acid secretion_Homo sapiens_hsa049710.21384211
98Renal cell carcinoma_Homo sapiens_hsa052110.20525658
99Leukocyte transendothelial migration_Homo sapiens_hsa046700.20418276
100Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.19786579
101Malaria_Homo sapiens_hsa051440.19168178
102ErbB signaling pathway_Homo sapiens_hsa040120.19133021
103Phagosome_Homo sapiens_hsa041450.18390662
104Pertussis_Homo sapiens_hsa051330.18202356
105Circadian rhythm_Homo sapiens_hsa047100.16726716
106Collecting duct acid secretion_Homo sapiens_hsa049660.16367594
107Legionellosis_Homo sapiens_hsa051340.15992357
108Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.14907129
109Glutathione metabolism_Homo sapiens_hsa004800.14801348
110Maturity onset diabetes of the young_Homo sapiens_hsa049500.14286462
111Dorso-ventral axis formation_Homo sapiens_hsa043200.13884446
112Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.13472036
113One carbon pool by folate_Homo sapiens_hsa006700.13372910
114Leishmaniasis_Homo sapiens_hsa051400.13088095
115VEGF signaling pathway_Homo sapiens_hsa043700.12874887
116Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.12521138
117Tuberculosis_Homo sapiens_hsa051520.12499748
118Lysosome_Homo sapiens_hsa041420.11937917
119MicroRNAs in cancer_Homo sapiens_hsa052060.11758192
120Melanoma_Homo sapiens_hsa052180.11502154
121TNF signaling pathway_Homo sapiens_hsa046680.10869392
122Linoleic acid metabolism_Homo sapiens_hsa005910.10284495
123Arginine biosynthesis_Homo sapiens_hsa002200.09192456
124Salivary secretion_Homo sapiens_hsa049700.09141956
125Butanoate metabolism_Homo sapiens_hsa006500.08956900
126Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.08736840
127Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.08580997
128Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.05399350
129Arachidonic acid metabolism_Homo sapiens_hsa005900.01859983
130Ovarian steroidogenesis_Homo sapiens_hsa049130.00560144
131Pentose and glucuronate interconversions_Homo sapiens_hsa000400.00297758
132Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0694788
133Estrogen signaling pathway_Homo sapiens_hsa04915-0.0614902
134Cholinergic synapse_Homo sapiens_hsa04725-0.0572256
135Staphylococcus aureus infection_Homo sapiens_hsa05150-0.0557598
136Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623-0.0401726
137GnRH signaling pathway_Homo sapiens_hsa04912-0.0253300
138Tryptophan metabolism_Homo sapiens_hsa00380-0.0242251
139Vitamin B6 metabolism_Homo sapiens_hsa00750-0.0191782
140Cysteine and methionine metabolism_Homo sapiens_hsa00270-0.0142132

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