BTF3P8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein polyglutamylation (GO:0018095)6.06783790
2proteasome assembly (GO:0043248)6.04598097
3estrogen biosynthetic process (GO:0006703)5.04319718
4polyamine biosynthetic process (GO:0006596)4.81233154
5base-excision repair, AP site formation (GO:0006285)4.31020001
6regulation of immunoglobulin secretion (GO:0051023)4.30790796
7DNA deamination (GO:0045006)4.22312186
8regulation of isotype switching to IgG isotypes (GO:0048302)4.09121470
9thalamus development (GO:0021794)3.88904054
10adenosine metabolic process (GO:0046085)3.83196877
11axoneme assembly (GO:0035082)3.82409222
12negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.82390362
13cullin deneddylation (GO:0010388)3.80186582
14polyamine metabolic process (GO:0006595)3.77085681
15mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.74837599
16mitochondrial respiratory chain complex I assembly (GO:0032981)3.74837599
17NADH dehydrogenase complex assembly (GO:0010257)3.74837599
18GTP biosynthetic process (GO:0006183)3.73423474
19protein deneddylation (GO:0000338)3.70248051
20somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.69739012
21somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.69739012
22isotype switching (GO:0045190)3.69739012
23regulation of chronic inflammatory response (GO:0002676)3.68754543
24GPI anchor biosynthetic process (GO:0006506)3.61481990
25organelle disassembly (GO:1903008)3.59259805
26cellular biogenic amine biosynthetic process (GO:0042401)3.58302270
27regulation of MHC class II biosynthetic process (GO:0045346)3.57915779
28positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.55194080
29amine biosynthetic process (GO:0009309)3.52671577
30regulation of podosome assembly (GO:0071801)3.52550261
31negative regulation of systemic arterial blood pressure (GO:0003085)3.38562042
32negative regulation of heart rate (GO:0010459)3.37662231
33ribonucleoprotein complex disassembly (GO:0032988)3.35508197
34transcription elongation from RNA polymerase III promoter (GO:0006385)3.34934704
35termination of RNA polymerase III transcription (GO:0006386)3.34934704
36GPI anchor metabolic process (GO:0006505)3.33962739
37aldehyde catabolic process (GO:0046185)3.33875567
38chaperone-mediated protein transport (GO:0072321)3.33330689
39protein targeting to mitochondrion (GO:0006626)3.32442362
40water-soluble vitamin biosynthetic process (GO:0042364)3.32117792
41negative regulation of potassium ion transmembrane transport (GO:1901380)3.30431316
42regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.29318550
43regulation of mitotic spindle checkpoint (GO:1903504)3.29205424
44regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.29205424
45DNA demethylation (GO:0080111)3.28376014
46protein complex biogenesis (GO:0070271)3.28354004
47somatic diversification of immune receptors via somatic mutation (GO:0002566)3.26129761
48somatic hypermutation of immunoglobulin genes (GO:0016446)3.26129761
49negative regulation of sodium ion transport (GO:0010766)3.19711683
50piRNA metabolic process (GO:0034587)3.19547336
51nucleotide transmembrane transport (GO:1901679)3.19509322
52rRNA modification (GO:0000154)3.17339132
53arginine catabolic process (GO:0006527)3.14340892
54preassembly of GPI anchor in ER membrane (GO:0016254)3.12900476
55tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.10026834
56RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.10026834
57mitochondrial respiratory chain complex assembly (GO:0033108)3.04605397
58kinetochore assembly (GO:0051382)3.02851142
59glycolipid biosynthetic process (GO:0009247)3.02235464
60UTP metabolic process (GO:0046051)3.01346249
61establishment of protein localization to mitochondrion (GO:0072655)2.97376409
62protein localization to mitochondrion (GO:0070585)2.95727520
63positive regulation of activated T cell proliferation (GO:0042104)2.95264560
64DNA damage response, detection of DNA damage (GO:0042769)2.94972426
65UTP biosynthetic process (GO:0006228)2.93944978
66CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.86680639
67cytidine deamination (GO:0009972)2.86464931
68cytidine metabolic process (GO:0046087)2.86464931
69cytidine catabolic process (GO:0006216)2.86464931
70regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.86350569
71ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.85965585
72drug transport (GO:0015893)2.84929766
73kinetochore organization (GO:0051383)2.82945111
74CTP metabolic process (GO:0046036)2.81557490
75CTP biosynthetic process (GO:0006241)2.81557490
76DNA replication-dependent nucleosome assembly (GO:0006335)2.77106040
77DNA replication-dependent nucleosome organization (GO:0034723)2.77106040
78response to oxygen radical (GO:0000305)2.74953481
79DNA dealkylation (GO:0035510)2.72169778
80negative regulation of T-helper cell differentiation (GO:0045623)2.72104153
81negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.72104153
82pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.71592175
83rRNA methylation (GO:0031167)2.71150724
84pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.69934706
85negative regulation of appetite (GO:0032099)2.69126191
86negative regulation of response to food (GO:0032096)2.69126191
87chromatin remodeling at centromere (GO:0031055)2.68835482
88CENP-A containing nucleosome assembly (GO:0034080)2.68654635
89oligosaccharide biosynthetic process (GO:0009312)2.67554451
90photoreceptor cell maintenance (GO:0045494)2.65345080
91isoprenoid biosynthetic process (GO:0008299)2.63962312
92pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.63259504
93negative regulation of nitric oxide biosynthetic process (GO:0045019)2.62426093
94regulation of tight junction assembly (GO:2000810)2.61855225
95guanosine-containing compound biosynthetic process (GO:1901070)2.59934954
96positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.59932404
97pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.59395905
98negative regulation by host of viral transcription (GO:0043922)2.56968945
99positive regulation of isotype switching (GO:0045830)2.56077995
100establishment of protein localization to mitochondrial membrane (GO:0090151)2.54464352

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse7.45799365
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.04040610
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.77018083
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.56982321
5EST1_17652178_ChIP-ChIP_JURKAT_Human2.99132758
6VDR_22108803_ChIP-Seq_LS180_Human2.94807916
7IRF1_19129219_ChIP-ChIP_H3396_Human2.74276934
8ZNF274_21170338_ChIP-Seq_K562_Hela2.73669783
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.69581732
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.68670285
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.55197382
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.43365966
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.38309237
14TAF15_26573619_Chip-Seq_HEK293_Human2.17415677
15VDR_23849224_ChIP-Seq_CD4+_Human2.14093820
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.05073711
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.02829857
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.00428808
19ELK1_19687146_ChIP-ChIP_HELA_Human1.98197965
20EZH2_22144423_ChIP-Seq_EOC_Human1.97639711
21FOXP3_21729870_ChIP-Seq_TREG_Human1.88851804
22MYC_18940864_ChIP-ChIP_HL60_Human1.86088750
23EWS_26573619_Chip-Seq_HEK293_Human1.83579189
24E2F4_17652178_ChIP-ChIP_JURKAT_Human1.82731674
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.81843922
26HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.80609490
27FUS_26573619_Chip-Seq_HEK293_Human1.80295012
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.78616744
29PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64626166
30IGF1R_20145208_ChIP-Seq_DFB_Human1.61537752
31GBX2_23144817_ChIP-Seq_PC3_Human1.58474126
32NOTCH1_21737748_ChIP-Seq_TLL_Human1.56899957
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.54511151
34MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.50293569
35CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.49042955
36AUTS2_25519132_ChIP-Seq_293T-REX_Human1.47908414
37MYC_18555785_ChIP-Seq_MESCs_Mouse1.47655049
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.47602192
39P300_19829295_ChIP-Seq_ESCs_Human1.47524315
40GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.46464444
41SRF_21415370_ChIP-Seq_HL-1_Mouse1.44336902
42POU3F2_20337985_ChIP-ChIP_501MEL_Human1.42827198
43ELF1_17652178_ChIP-ChIP_JURKAT_Human1.42220647
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.38204995
45PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.35973496
46TP53_22573176_ChIP-Seq_HFKS_Human1.35091431
47EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.33591381
48GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.33267991
49POU5F1_16153702_ChIP-ChIP_HESCs_Human1.29704572
50PCGF2_27294783_Chip-Seq_NPCs_Mouse1.26894681
51KLF5_20875108_ChIP-Seq_MESCs_Mouse1.26735005
52CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.26317756
53FOXA1_27270436_Chip-Seq_PROSTATE_Human1.24166364
54FOXA1_25329375_ChIP-Seq_VCAP_Human1.24166364
55HOXB4_20404135_ChIP-ChIP_EML_Mouse1.23537201
56CTBP2_25329375_ChIP-Seq_LNCAP_Human1.22530700
57IKZF1_21737484_ChIP-ChIP_HCT116_Human1.19725710
58TTF2_22483619_ChIP-Seq_HELA_Human1.19034102
59CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.18138088
60DCP1A_22483619_ChIP-Seq_HELA_Human1.13132896
61HTT_18923047_ChIP-ChIP_STHdh_Human1.12462002
62ERG_20517297_ChIP-Seq_VCAP_Human1.11433927
63CBP_20019798_ChIP-Seq_JUKART_Human1.08937789
64IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.08937789
65PADI4_21655091_ChIP-ChIP_MCF-7_Human1.03429035
66NANOG_19829295_ChIP-Seq_ESCs_Human1.02081319
67SOX2_19829295_ChIP-Seq_ESCs_Human1.02081319
68PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.01215127
69NCOR_22424771_ChIP-Seq_293T_Human0.99415557
70EZH2_27294783_Chip-Seq_NPCs_Mouse0.99130242
71GABP_19822575_ChIP-Seq_HepG2_Human0.99068714
72TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98891223
73TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98472335
74BCAT_22108803_ChIP-Seq_LS180_Human0.97267534
75FOXA1_21572438_ChIP-Seq_LNCaP_Human0.94672629
76SOX2_16153702_ChIP-ChIP_HESCs_Human0.93177620
77GATA3_21878914_ChIP-Seq_MCF-7_Human0.93060125
78SOX2_18555785_ChIP-Seq_MESCs_Mouse0.92606728
79AR_20517297_ChIP-Seq_VCAP_Human0.92582720
80CRX_20693478_ChIP-Seq_RETINA_Mouse0.92246637
81FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.91772632
82UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91342739
83RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.90056574
84PRDM14_20953172_ChIP-Seq_ESCs_Human0.88452862
85MYC_18358816_ChIP-ChIP_MESCs_Mouse0.84904650
86NANOG_16153702_ChIP-ChIP_HESCs_Human0.84799726
87NELFA_20434984_ChIP-Seq_ESCs_Mouse0.84567443
88GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.82873816
89LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81766218
90LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.80504496
91PHF8_20622853_ChIP-Seq_HELA_Human0.80134644
92IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.79894172
93RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79497299
94NFE2_27457419_Chip-Seq_LIVER_Mouse0.78955741
95NANOG_20526341_ChIP-Seq_ESCs_Human0.76427434
96FLI1_21867929_ChIP-Seq_TH2_Mouse0.75472504
97TAL1_26923725_Chip-Seq_HPCs_Mouse0.75195014
98ER_23166858_ChIP-Seq_MCF-7_Human0.74866425
99SUZ12_27294783_Chip-Seq_NPCs_Mouse0.74373644
100YY1_22570637_ChIP-Seq_MALME-3M_Human0.74248882

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology3.97011244
2MP0008875_abnormal_xenobiotic_pharmacok3.53136773
3MP0001348_abnormal_lacrimal_gland2.98039492
4MP0002837_dystrophic_cardiac_calcinosis2.83391683
5MP0003718_maternal_effect2.68584706
6MP0000465_gastrointestinal_hemorrhage2.57150352
7MP0008872_abnormal_physiological_respon2.52689014
8MP0008877_abnormal_DNA_methylation2.48900706
9MP0002736_abnormal_nociception_after2.48138455
10MP0001968_abnormal_touch/_nociception2.44660889
11MP0005085_abnormal_gallbladder_physiolo2.37262934
12MP0003186_abnormal_redox_activity2.25924292
13MP0006082_CNS_inflammation2.21518086
14MP0001873_stomach_inflammation2.19367997
15MP0010094_abnormal_chromosome_stability2.16198005
16MP0003693_abnormal_embryo_hatching2.08522469
17MP0002102_abnormal_ear_morphology1.96331094
18MP0008007_abnormal_cellular_replicative1.92712103
19MP0002876_abnormal_thyroid_physiology1.91249868
20MP0006072_abnormal_retinal_apoptosis1.89903606
21MP0001835_abnormal_antigen_presentation1.87010494
22MP0005551_abnormal_eye_electrophysiolog1.86821385
23MP0005645_abnormal_hypothalamus_physiol1.78385779
24MP0003252_abnormal_bile_duct1.75833859
25MP0005646_abnormal_pituitary_gland1.72033156
26MP0004142_abnormal_muscle_tone1.69831718
27MP0008058_abnormal_DNA_repair1.69638937
28MP0010368_abnormal_lymphatic_system1.57507357
29MP0006276_abnormal_autonomic_nervous1.55751428
30MP0006292_abnormal_olfactory_placode1.50674166
31MP0002638_abnormal_pupillary_reflex1.50012484
32MP0005464_abnormal_platelet_physiology1.48457240
33MP0005167_abnormal_blood-brain_barrier1.47061734
34MP0001529_abnormal_vocalization1.40099121
35MP0005671_abnormal_response_to1.38514928
36MP0004957_abnormal_blastocyst_morpholog1.38306412
37MP0003122_maternal_imprinting1.37663527
38MP0002138_abnormal_hepatobiliary_system1.37181383
39MP0005253_abnormal_eye_physiology1.37064386
40MP0005636_abnormal_mineral_homeostasis1.35627045
41MP0003646_muscle_fatigue1.34267213
42MP0001293_anophthalmia1.29515801
43MP0003195_calcinosis1.28107251
44MP0003567_abnormal_fetal_cardiomyocyte1.25484146
45MP0005084_abnormal_gallbladder_morpholo1.23842758
46MP0003787_abnormal_imprinting1.22891695
47MP0001664_abnormal_digestion1.22621846
48MP0003786_premature_aging1.20911365
49MP0002160_abnormal_reproductive_system1.19738889
50MP0003763_abnormal_thymus_physiology1.19508294
51MP0000569_abnormal_digit_pigmentation1.16679369
52MP0004145_abnormal_muscle_electrophysio1.14553320
53MP0001188_hyperpigmentation1.10335176
54MP0009697_abnormal_copulation1.09116387
55MP0005174_abnormal_tail_pigmentation1.08430204
56MP0009745_abnormal_behavioral_response1.04798418
57MP0004084_abnormal_cardiac_muscle1.02931764
58MP0005075_abnormal_melanosome_morpholog1.02811189
59MP0001764_abnormal_homeostasis0.99921542
60MP0004742_abnormal_vestibular_system0.99339452
61MP0005310_abnormal_salivary_gland0.97540124
62MP0001984_abnormal_olfaction0.96893567
63MP0008004_abnormal_stomach_pH0.96100789
64MP0002396_abnormal_hematopoietic_system0.93166368
65MP0005365_abnormal_bile_salt0.92420171
66MP0009765_abnormal_xenobiotic_induced0.91044957
67MP0004147_increased_porphyrin_level0.90931909
68MP0002067_abnormal_sensory_capabilities0.90930494
69MP0002733_abnormal_thermal_nociception0.90156603
70MP0003121_genomic_imprinting0.89273877
71MP0006036_abnormal_mitochondrial_physio0.87094824
72MP0002163_abnormal_gland_morphology0.85114520
73MP0001881_abnormal_mammary_gland0.83893649
74MP0003959_abnormal_lean_body0.83123531
75MP0009333_abnormal_splenocyte_physiolog0.81905644
76MP0005584_abnormal_enzyme/coenzyme_acti0.80019837
77MP0005387_immune_system_phenotype0.79579000
78MP0001790_abnormal_immune_system0.79579000
79MP0002272_abnormal_nervous_system0.78928085
80MP0003698_abnormal_male_reproductive0.76950037
81MP0001905_abnormal_dopamine_level0.76768681
82MP0001929_abnormal_gametogenesis0.76466112
83MP0002210_abnormal_sex_determination0.75293833
84MP0005389_reproductive_system_phenotype0.74566403
85MP0001324_abnormal_eye_pigmentation0.74429681
86MP0002557_abnormal_social/conspecific_i0.73458225
87MP0005670_abnormal_white_adipose0.73390153
88MP0002277_abnormal_respiratory_mucosa0.73354947
89MP0000653_abnormal_sex_gland0.72112673
90MP0000372_irregular_coat_pigmentation0.69366135
91MP0004043_abnormal_pH_regulation0.68747740
92MP0005410_abnormal_fertilization0.68721495
93MP0005195_abnormal_posterior_eye0.67695695
94MP0002229_neurodegeneration0.67677492
95MP0002572_abnormal_emotion/affect_behav0.67061950
96MP0002132_abnormal_respiratory_system0.66969591
97MP0000689_abnormal_spleen_morphology0.66918314
98MP0009764_decreased_sensitivity_to0.66096408
99MP0000778_abnormal_nervous_system0.64856470
100MP0001800_abnormal_humoral_immune0.64639962

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of macular pigmentation (HP:0008002)5.76327722
2Reduced antithrombin III activity (HP:0001976)4.79123355
3Absent rod-and cone-mediated responses on ERG (HP:0007688)4.70614266
4Abnormal rod and cone electroretinograms (HP:0008323)4.35938629
5Decreased central vision (HP:0007663)4.11388051
6Congenital stationary night blindness (HP:0007642)3.97678182
7Dyschromatopsia (HP:0007641)3.83848740
8Colon cancer (HP:0003003)3.45203329
9Facial hemangioma (HP:0000329)3.32209979
10Abolished electroretinogram (ERG) (HP:0000550)3.02780182
11Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.01776411
12Abnormality of alanine metabolism (HP:0010916)3.01776411
13Hyperalaninemia (HP:0003348)3.01776411
14Abnormal protein glycosylation (HP:0012346)2.99248770
15Abnormal glycosylation (HP:0012345)2.99248770
16Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.99248770
17Abnormal protein N-linked glycosylation (HP:0012347)2.99248770
18Severe visual impairment (HP:0001141)2.98034879
19Stomatitis (HP:0010280)2.74488717
20Macular degeneration (HP:0000608)2.73354912
21Abnormality of the labia minora (HP:0012880)2.72384376
22Central scotoma (HP:0000603)2.70201516
23Renal cortical cysts (HP:0000803)2.61531370
24Short tibia (HP:0005736)2.55695653
25Pendular nystagmus (HP:0012043)2.54738838
26Short 1st metacarpal (HP:0010034)2.54100458
27Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.54100458
28Self-mutilation (HP:0000742)2.53266137
29Capillary hemangiomas (HP:0005306)2.51935899
303-Methylglutaconic aciduria (HP:0003535)2.50072194
31Aplasia/Hypoplasia of the tibia (HP:0005772)2.43219685
32Medial flaring of the eyebrow (HP:0010747)2.43205910
33Unsteady gait (HP:0002317)2.39523292
34Microretrognathia (HP:0000308)2.35634655
35Poor suck (HP:0002033)2.32528929
36Abnormality of the 1st metacarpal (HP:0010009)2.27968418
37Abnormal pupillary function (HP:0007686)2.27172710
38Abnormality of the prostate (HP:0008775)2.26747373
39Conjugated hyperbilirubinemia (HP:0002908)2.24817799
40Nephronophthisis (HP:0000090)2.24021436
41Increased CSF lactate (HP:0002490)2.21419323
42Abnormality of the columella (HP:0009929)2.13155806
43Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.11528232
44Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.11452844
45Abnormality of the renal cortex (HP:0011035)2.11126513
46Chromosomal breakage induced by crosslinking agents (HP:0003221)2.08406773
47Prostate neoplasm (HP:0100787)2.03210635
48Cone-rod dystrophy (HP:0000548)2.01923191
49Abnormality of the phalanges of the 5th finger (HP:0004213)2.00605162
50Hepatocellular necrosis (HP:0001404)2.00223827
51Abnormality of midbrain morphology (HP:0002418)1.99785302
52Molar tooth sign on MRI (HP:0002419)1.99785302
53Large for gestational age (HP:0001520)1.98568470
54Mitochondrial inheritance (HP:0001427)1.96517880
55Attenuation of retinal blood vessels (HP:0007843)1.96119339
56Pancreatic cysts (HP:0001737)1.95712766
57Progressive inability to walk (HP:0002505)1.94398161
58Abnormality of the phalanges of the 2nd finger (HP:0009541)1.93786041
59Polyphagia (HP:0002591)1.91623397
60Generalized hypotonia (HP:0001290)1.90924269
61Increased serum lactate (HP:0002151)1.90319066
62Optic disc pallor (HP:0000543)1.87016634
63Acute necrotizing encephalopathy (HP:0006965)1.84222215
64Lactic acidosis (HP:0003128)1.82638217
65Growth hormone deficiency (HP:0000824)1.82342465
66Hypoplasia of the thymus (HP:0000778)1.82240107
67Hepatic necrosis (HP:0002605)1.81562046
68Parakeratosis (HP:0001036)1.81550702
69Increased IgM level (HP:0003496)1.81120461
70Constricted visual fields (HP:0001133)1.79861443
71Nephrogenic diabetes insipidus (HP:0009806)1.79850552
72Decreased activity of mitochondrial respiratory chain (HP:0008972)1.79256488
73Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.79256488
74Decreased electroretinogram (ERG) amplitude (HP:0000654)1.76902743
75Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.76875477
76Protruding tongue (HP:0010808)1.76662104
77Brushfield spots (HP:0001088)1.75506891
78IgG deficiency (HP:0004315)1.73968638
79Thoracolumbar scoliosis (HP:0002944)1.73772066
80Lissencephaly (HP:0001339)1.73658689
81Abnormal mitochondria in muscle tissue (HP:0008316)1.72534159
82Meckel diverticulum (HP:0002245)1.72498120
83Asplenia (HP:0001746)1.71765639
84Keratoconus (HP:0000563)1.71217307
85Increased corneal curvature (HP:0100692)1.71217307
86Petechiae (HP:0000967)1.70514438
87Overlapping toe (HP:0001845)1.70477341
88Aplasia/Hypoplasia of the spleen (HP:0010451)1.70454742
89Congenital primary aphakia (HP:0007707)1.70422733
90Gait imbalance (HP:0002141)1.68974174
91Acute encephalopathy (HP:0006846)1.68905201
92Inability to walk (HP:0002540)1.68626134
93Palpebral edema (HP:0100540)1.67455014
94Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.67101295
95Astigmatism (HP:0000483)1.66939306
96Albinism (HP:0001022)1.66825434
97Methylmalonic aciduria (HP:0012120)1.66619535
98Scotoma (HP:0000575)1.65289863
99Abnormality of aspartate family amino acid metabolism (HP:0010899)1.64727908
100Abnormality of T cell physiology (HP:0011840)1.62905553

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK3.72302606
2EIF2AK13.47677045
3ZAK3.18470545
4TXK3.07198405
5TNIK2.78295779
6MAP4K22.37520211
7BCR2.31847309
8DAPK22.18282254
9TRIM282.04685273
10SRPK12.03499832
11VRK21.98795451
12MAP4K11.80250569
13WNK31.78593645
14PIM21.76466247
15MAP2K71.76108496
16BUB11.74870557
17ADRBK21.65033774
18FLT31.60443444
19KDR1.54345107
20NUAK11.49604722
21MAPK131.46004312
22PRKG21.43900509
23VRK11.38448289
24GRK11.37447893
25CSNK1G31.30539496
26ERBB31.29494120
27MKNK11.28831011
28MST41.27502426
29BMPR1B1.20241096
30PLK21.19260032
31DAPK11.17918886
32ITK1.15146149
33DYRK21.14809176
34TEC1.12737417
35TAOK31.10729884
36BRAF1.09204207
37CSNK1G21.07176051
38PLK31.06146284
39PINK11.05660907
40TNK21.05154576
41CSNK1A1L1.04159652
42STK41.02740232
43WNK40.98302408
44MAP3K40.97151702
45ARAF0.95757411
46RPS6KA40.95164328
47MKNK20.90602581
48CSNK1G10.90557203
49BCKDK0.88295070
50GRK50.87569672
51TIE10.86841753
52TLK10.86715588
53STK390.85827900
54EIF2AK20.83313997
55AKT30.82885504
56CDC70.82395445
57EIF2AK30.82073274
58WEE10.81853011
59LMTK20.79720560
60TSSK60.79695226
61TAF10.78967851
62PRKCQ0.75433442
63NME10.71957688
64PLK40.70044145
65STK160.67172232
66BRD40.63927227
67OXSR10.63826197
68GRK70.61901795
69ATR0.59651265
70RPS6KA50.59594524
71DAPK30.58861379
72CAMKK20.55327945
73CASK0.53544725
74INSRR0.53417522
75GRK60.51195643
76MAPK100.48476861
77PLK10.48187471
78ACVR1B0.47481271
79NLK0.46951270
80PRKCE0.45677283
81CSF1R0.44883272
82RPS6KA60.44873664
83PTK2B0.43657110
84PHKG10.42033423
85PHKG20.42033423
86ERBB20.41655431
87ADRBK10.40491573
88NEK10.39756145
89RPS6KA10.36419125
90CSNK1A10.35823782
91PIM10.35548508
92MYLK0.34948196
93PAK30.34943197
94CSNK2A10.34665129
95FRK0.34465159
96STK30.33839380
97ATM0.33105861
98ABL20.32985170
99MAPKAPK50.32589806
100PRKACA0.32235956

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053103.46652269
2Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.29226797
3Allograft rejection_Homo sapiens_hsa053303.07760477
4Protein export_Homo sapiens_hsa030603.03797005
5Autoimmune thyroid disease_Homo sapiens_hsa053202.99027491
6Proteasome_Homo sapiens_hsa030502.77312475
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.65366942
8RNA polymerase_Homo sapiens_hsa030202.46955717
9Vitamin B6 metabolism_Homo sapiens_hsa007502.26372255
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.22938846
11Oxidative phosphorylation_Homo sapiens_hsa001901.87507111
12Fatty acid elongation_Homo sapiens_hsa000621.82963560
13Cysteine and methionine metabolism_Homo sapiens_hsa002701.79125489
14Parkinsons disease_Homo sapiens_hsa050121.78993672
15Phototransduction_Homo sapiens_hsa047441.68077556
16Basal transcription factors_Homo sapiens_hsa030221.65076204
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.63277743
18Homologous recombination_Homo sapiens_hsa034401.58481806
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.54630622
20Arginine and proline metabolism_Homo sapiens_hsa003301.47879568
21DNA replication_Homo sapiens_hsa030301.44625860
22Nitrogen metabolism_Homo sapiens_hsa009101.43714852
23Steroid biosynthesis_Homo sapiens_hsa001001.43507043
24Caffeine metabolism_Homo sapiens_hsa002321.41045112
25Fanconi anemia pathway_Homo sapiens_hsa034601.39542243
26Graft-versus-host disease_Homo sapiens_hsa053321.36366297
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.35732195
28Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.34184598
29Pyrimidine metabolism_Homo sapiens_hsa002401.33118272
30Butanoate metabolism_Homo sapiens_hsa006501.31394463
31Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.28247225
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.26097855
33Mismatch repair_Homo sapiens_hsa034301.25320531
34Propanoate metabolism_Homo sapiens_hsa006401.25016913
35Base excision repair_Homo sapiens_hsa034101.22593861
36Selenocompound metabolism_Homo sapiens_hsa004501.17517816
37Sulfur metabolism_Homo sapiens_hsa009201.16336477
38Ribosome_Homo sapiens_hsa030101.15224405
39Non-homologous end-joining_Homo sapiens_hsa034501.14779917
40Huntingtons disease_Homo sapiens_hsa050161.14037672
41Peroxisome_Homo sapiens_hsa041461.12988868
42Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.12105576
43Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.08920371
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.02510622
45Nucleotide excision repair_Homo sapiens_hsa034201.01515039
46Ether lipid metabolism_Homo sapiens_hsa005651.00767628
47Primary bile acid biosynthesis_Homo sapiens_hsa001200.96854866
48Hematopoietic cell lineage_Homo sapiens_hsa046400.96431660
49Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.96244419
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.94270983
51Primary immunodeficiency_Homo sapiens_hsa053400.89991358
52Alzheimers disease_Homo sapiens_hsa050100.89053315
53Carbon metabolism_Homo sapiens_hsa012000.88833133
54Arachidonic acid metabolism_Homo sapiens_hsa005900.87576119
55Purine metabolism_Homo sapiens_hsa002300.87419355
56Linoleic acid metabolism_Homo sapiens_hsa005910.87357376
57Ovarian steroidogenesis_Homo sapiens_hsa049130.84662430
58Spliceosome_Homo sapiens_hsa030400.83851607
59beta-Alanine metabolism_Homo sapiens_hsa004100.83391973
60Rheumatoid arthritis_Homo sapiens_hsa053230.83173591
61Pentose and glucuronate interconversions_Homo sapiens_hsa000400.82140045
62RNA transport_Homo sapiens_hsa030130.81714486
63Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.79829074
64Nicotine addiction_Homo sapiens_hsa050330.79772831
65Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.78791665
66Type I diabetes mellitus_Homo sapiens_hsa049400.75907959
67Salivary secretion_Homo sapiens_hsa049700.74081718
68Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.71930649
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.70973051
70Chemical carcinogenesis_Homo sapiens_hsa052040.69385897
71Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.66997359
72RNA degradation_Homo sapiens_hsa030180.66822732
73Pentose phosphate pathway_Homo sapiens_hsa000300.65142886
74Biosynthesis of amino acids_Homo sapiens_hsa012300.64903900
75Metabolic pathways_Homo sapiens_hsa011000.64660200
76Fatty acid degradation_Homo sapiens_hsa000710.64483607
77Tryptophan metabolism_Homo sapiens_hsa003800.63456686
78Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.61561940
79Retinol metabolism_Homo sapiens_hsa008300.61472161
80T cell receptor signaling pathway_Homo sapiens_hsa046600.60787489
81Glutathione metabolism_Homo sapiens_hsa004800.58442027
82Cardiac muscle contraction_Homo sapiens_hsa042600.54666603
83Systemic lupus erythematosus_Homo sapiens_hsa053220.51888843
84alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.50626994
85Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49490279
86Long-term depression_Homo sapiens_hsa047300.45718590
87Mineral absorption_Homo sapiens_hsa049780.45185937
88Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43022194
89Olfactory transduction_Homo sapiens_hsa047400.42293171
90Pyruvate metabolism_Homo sapiens_hsa006200.40269468
91Starch and sucrose metabolism_Homo sapiens_hsa005000.39324192
92Cell cycle_Homo sapiens_hsa041100.37417079
93One carbon pool by folate_Homo sapiens_hsa006700.37078925
94Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.36102992
95Glycerophospholipid metabolism_Homo sapiens_hsa005640.36055606
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.34926920
97Viral myocarditis_Homo sapiens_hsa054160.31722787
98Antigen processing and presentation_Homo sapiens_hsa046120.30292168
99GABAergic synapse_Homo sapiens_hsa047270.30247405
100Serotonergic synapse_Homo sapiens_hsa047260.29846801

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