BTF3P13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of protein localization to mitochondrial membrane (GO:0090151)4.67840815
2xenobiotic catabolic process (GO:0042178)4.60078460
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.49774959
4response to pheromone (GO:0019236)4.41237066
5chaperone mediated protein folding requiring cofactor (GO:0051085)4.38020531
6proteasome assembly (GO:0043248)4.26629274
7mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.15280875
8mitochondrial respiratory chain complex I assembly (GO:0032981)4.15280875
9NADH dehydrogenase complex assembly (GO:0010257)4.15280875
10ATP synthesis coupled proton transport (GO:0015986)4.10292641
11energy coupled proton transport, down electrochemical gradient (GO:0015985)4.10292641
12GTP biosynthetic process (GO:0006183)4.07887227
13positive regulation of prostaglandin secretion (GO:0032308)3.99427208
14protein complex biogenesis (GO:0070271)3.93385713
15phenylpropanoid metabolic process (GO:0009698)3.87269134
16regulation of immunoglobulin secretion (GO:0051023)3.85066614
17water-soluble vitamin biosynthetic process (GO:0042364)3.79522937
18transcription elongation from RNA polymerase III promoter (GO:0006385)3.77209280
19termination of RNA polymerase III transcription (GO:0006386)3.77209280
20chaperone-mediated protein transport (GO:0072321)3.68434818
21mitochondrial respiratory chain complex assembly (GO:0033108)3.64465890
22UTP biosynthetic process (GO:0006228)3.58990295
23UTP metabolic process (GO:0046051)3.58309825
24protein localization to cilium (GO:0061512)3.46664236
25ribosomal large subunit biogenesis (GO:0042273)3.44480884
26DNA deamination (GO:0045006)3.37619052
27cell wall macromolecule catabolic process (GO:0016998)3.34706228
28preassembly of GPI anchor in ER membrane (GO:0016254)3.34380888
29pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.31267095
30somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.29348346
31somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.29348346
32isotype switching (GO:0045190)3.29348346
33piRNA metabolic process (GO:0034587)3.25223453
34protein refolding (GO:0042026)3.23799793
35protein prenylation (GO:0018342)3.19737272
36prenylation (GO:0097354)3.19737272
37regulation of prostaglandin secretion (GO:0032306)3.16287627
38DNA damage response, detection of DNA damage (GO:0042769)3.15776357
39termination of RNA polymerase I transcription (GO:0006363)3.14636714
40pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.13600904
41transcription elongation from RNA polymerase I promoter (GO:0006362)3.06603812
42CTP metabolic process (GO:0046036)3.03834376
43CTP biosynthetic process (GO:0006241)3.03834376
44regulation of meiosis I (GO:0060631)3.02944925
452-deoxyribonucleotide biosynthetic process (GO:0009265)3.01238873
46deoxyribose phosphate biosynthetic process (GO:0046385)3.01238873
47magnesium ion transport (GO:0015693)3.00974974
48autophagic vacuole fusion (GO:0000046)2.93231747
49tryptophan metabolic process (GO:0006568)2.91077361
50protein deneddylation (GO:0000338)2.88649302
51cell wall macromolecule metabolic process (GO:0044036)2.85522209
52benzene-containing compound metabolic process (GO:0042537)2.83636252
53mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.81647376
54type B pancreatic cell development (GO:0003323)2.80879336
55mitochondrial calcium ion transport (GO:0006851)2.79238095
56pseudouridine synthesis (GO:0001522)2.78386127
57pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.78256590
58synapsis (GO:0007129)2.76780287
59exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.76479642
60negative regulation of acute inflammatory response (GO:0002674)2.76374464
61mannosylation (GO:0097502)2.74700431
62pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.74300639
63purine nucleoside triphosphate biosynthetic process (GO:0009145)2.73578812
64nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.71401672
65guanosine-containing compound biosynthetic process (GO:1901070)2.70646263
66plasma membrane fusion (GO:0045026)2.68692801
67aggressive behavior (GO:0002118)2.68221113
68regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.66585460
69regulation of mitotic spindle checkpoint (GO:1903504)2.66585460
70pyrimidine ribonucleoside biosynthetic process (GO:0046132)2.65399298
71somite development (GO:0061053)2.65317630
72protein-cofactor linkage (GO:0018065)2.63112736
73purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.62450023
74GPI anchor metabolic process (GO:0006505)2.62069222
75regulation of female receptivity (GO:0045924)2.61445681
76DNA methylation involved in gamete generation (GO:0043046)2.60584824
77electron transport chain (GO:0022900)2.58053938
78toxin metabolic process (GO:0009404)2.56960215
79respiratory electron transport chain (GO:0022904)2.56709400
80regulation of mitochondrial translation (GO:0070129)2.56221961
81pyrimidine nucleotide biosynthetic process (GO:0006221)2.55897218
82female mating behavior (GO:0060180)2.55560761
83intraciliary transport (GO:0042073)2.55404175
84maturation of 5.8S rRNA (GO:0000460)2.55222005
85transcription initiation from RNA polymerase I promoter (GO:0006361)2.54311401
86cullin deneddylation (GO:0010388)2.54136158
87transcription from RNA polymerase I promoter (GO:0006360)2.52131899
88positive regulation of mast cell degranulation (GO:0043306)2.51994283
89positive regulation of mast cell activation involved in immune response (GO:0033008)2.51994283
90parental behavior (GO:0060746)2.51964922
91spermatid nucleus differentiation (GO:0007289)2.49102944
92regulation of penile erection (GO:0060405)2.48461868
93pyrimidine ribonucleotide biosynthetic process (GO:0009220)2.47426909
94nucleoside diphosphate phosphorylation (GO:0006165)2.47305256
95oxidative phosphorylation (GO:0006119)2.46400510
96RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.46111667
97tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.46111667
98positive regulation of icosanoid secretion (GO:0032305)2.45861918
99protein neddylation (GO:0045116)2.45528075
100nucleotide transmembrane transport (GO:1901679)2.44449953

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.38169975
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.76523471
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.65489565
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.22689202
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.02151016
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.76692642
7VDR_22108803_ChIP-Seq_LS180_Human2.68304735
8ZNF274_21170338_ChIP-Seq_K562_Hela2.60707894
9EWS_26573619_Chip-Seq_HEK293_Human2.50556932
10TAF15_26573619_Chip-Seq_HEK293_Human2.47929630
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.39933344
12ELK1_19687146_ChIP-ChIP_HELA_Human2.37636473
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.34026414
14RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.18240541
15PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.16959678
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.14697546
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.10323502
18NOTCH1_21737748_ChIP-Seq_TLL_Human2.04831542
19IGF1R_20145208_ChIP-Seq_DFB_Human2.04441339
20VDR_23849224_ChIP-Seq_CD4+_Human1.99706149
21GBX2_23144817_ChIP-Seq_PC3_Human1.87559973
22JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.85964390
23CTBP1_25329375_ChIP-Seq_LNCAP_Human1.85687846
24PADI4_21655091_ChIP-ChIP_MCF-7_Human1.84214935
25MYC_18940864_ChIP-ChIP_HL60_Human1.78822765
26ETS1_20019798_ChIP-Seq_JURKAT_Human1.76164731
27ZFP57_27257070_Chip-Seq_ESCs_Mouse1.75122299
28EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.71963655
29GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.70221290
30TP53_22573176_ChIP-Seq_HFKS_Human1.68444644
31IRF8_21731497_ChIP-ChIP_J774_Mouse1.67474431
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.66192165
33P300_19829295_ChIP-Seq_ESCs_Human1.63338762
34CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.60188310
35FOXP3_21729870_ChIP-Seq_TREG_Human1.60076796
36UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.59367484
37NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.56513566
38IRF1_19129219_ChIP-ChIP_H3396_Human1.52620200
39ER_23166858_ChIP-Seq_MCF-7_Human1.49452433
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.49344050
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40968593
42NANOG_19829295_ChIP-Seq_ESCs_Human1.40322656
43SOX2_19829295_ChIP-Seq_ESCs_Human1.40322656
44EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.40295894
45HTT_18923047_ChIP-ChIP_STHdh_Human1.38859895
46PCGF2_27294783_Chip-Seq_ESCs_Mouse1.37026800
47AR_20517297_ChIP-Seq_VCAP_Human1.35853032
48AUTS2_25519132_ChIP-Seq_293T-REX_Human1.33952665
49ELF1_17652178_ChIP-ChIP_JURKAT_Human1.33220574
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.30689622
51CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.28971469
52CREB1_15753290_ChIP-ChIP_HEK293T_Human1.26398809
53FOXH1_21741376_ChIP-Seq_EPCs_Human1.22666475
54FUS_26573619_Chip-Seq_HEK293_Human1.22414559
55MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.22253657
56RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.22180969
57SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21919385
58ERG_20517297_ChIP-Seq_VCAP_Human1.20989844
59CDX2_22108803_ChIP-Seq_LS180_Human1.20974125
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.20873497
61GATA3_21878914_ChIP-Seq_MCF-7_Human1.20712744
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.20561986
63CBP_20019798_ChIP-Seq_JUKART_Human1.20561986
64AR_25329375_ChIP-Seq_VCAP_Human1.17849879
65AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16753582
66TDRD3_21172665_ChIP-Seq_MCF-7_Human1.16726193
67SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16598712
68FOXA1_21572438_ChIP-Seq_LNCaP_Human1.13926244
69NFE2_27457419_Chip-Seq_LIVER_Mouse1.12648570
70EZH2_27294783_Chip-Seq_NPCs_Mouse1.11886757
71RNF2_27304074_Chip-Seq_NSC_Mouse1.11403974
72FOXA1_27270436_Chip-Seq_PROSTATE_Human1.11384329
73FOXA1_25329375_ChIP-Seq_VCAP_Human1.11384329
74POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.10637686
75EZH2_22144423_ChIP-Seq_EOC_Human1.08657412
76OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08094668
77PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.06348015
78POU5F1_16153702_ChIP-ChIP_HESCs_Human1.05267649
79FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.03558932
80PCGF2_27294783_Chip-Seq_NPCs_Mouse1.02473450
81HOXB4_20404135_ChIP-ChIP_EML_Mouse1.01958034
82TCF4_23295773_ChIP-Seq_U87_Human1.01320784
83SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00376657
84TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99585140
85PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.99281625
86EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98770341
87CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.98657554
88TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97616304
89RBPJ_21746931_ChIP-Seq_IB4_Human0.97299277
90PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.97206040
91TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96669791
92POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96669791
93NANOG_18555785_Chip-Seq_ESCs_Mouse0.96519590
94TCF4_22108803_ChIP-Seq_LS180_Human0.96169219
95PRDM14_20953172_ChIP-Seq_ESCs_Human0.95690838
96MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95007254
97BCAT_22108803_ChIP-Seq_LS180_Human0.94341798
98FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.94303897
99HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.94126389
100SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.93627685

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008875_abnormal_xenobiotic_pharmacok4.68431745
2MP0003787_abnormal_imprinting3.58558841
3MP0001835_abnormal_antigen_presentation3.44694661
4MP0008877_abnormal_DNA_methylation3.21297979
5MP0003718_maternal_effect3.10639951
6MP0006072_abnormal_retinal_apoptosis3.01172372
7MP0002277_abnormal_respiratory_mucosa2.60125194
8MP0002102_abnormal_ear_morphology2.55871692
9MP0001984_abnormal_olfaction2.41096670
10MP0005646_abnormal_pituitary_gland2.35795597
11MP0008872_abnormal_physiological_respon2.30299653
12MP0006292_abnormal_olfactory_placode2.26349522
13MP0002160_abnormal_reproductive_system2.15326526
14MP0003806_abnormal_nucleotide_metabolis2.06875369
15MP0004885_abnormal_endolymph1.98594742
16MP0000631_abnormal_neuroendocrine_gland1.96711906
17MP0004133_heterotaxia1.93194795
18MP0002272_abnormal_nervous_system1.68366345
19MP0005551_abnormal_eye_electrophysiolog1.63118675
20MP0005084_abnormal_gallbladder_morpholo1.62480516
21MP0005389_reproductive_system_phenotype1.61969500
22MP0000372_irregular_coat_pigmentation1.61474684
23MP0005671_abnormal_response_to1.60888002
24MP0005075_abnormal_melanosome_morpholog1.55151631
25MP0005410_abnormal_fertilization1.50086655
26MP0001986_abnormal_taste_sensitivity1.49046069
27MP0001764_abnormal_homeostasis1.47068991
28MP0003121_genomic_imprinting1.40333046
29MP0002653_abnormal_ependyma_morphology1.38142896
30MP0008789_abnormal_olfactory_epithelium1.37801799
31MP0002138_abnormal_hepatobiliary_system1.35066713
32MP0008775_abnormal_heart_ventricle1.31187058
33MP0002938_white_spotting1.28259744
34MP0006036_abnormal_mitochondrial_physio1.26839216
35MP0002234_abnormal_pharynx_morphology1.23790071
36MP0005187_abnormal_penis_morphology1.22945403
37MP0000647_abnormal_sebaceous_gland1.21820294
38MP0001968_abnormal_touch/_nociception1.20523394
39MP0001529_abnormal_vocalization1.17442750
40MP0001756_abnormal_urination1.16614284
41MP0001873_stomach_inflammation1.16184525
42MP0005253_abnormal_eye_physiology1.10641437
43MP0001929_abnormal_gametogenesis1.09950638
44MP0003195_calcinosis1.08893706
45MP0009697_abnormal_copulation1.08609569
46MP0005085_abnormal_gallbladder_physiolo1.08515728
47MP0003011_delayed_dark_adaptation1.07734021
48MP0004142_abnormal_muscle_tone1.04951916
49MP0003122_maternal_imprinting1.04738653
50MP0002693_abnormal_pancreas_physiology1.01909013
51MP0009745_abnormal_behavioral_response1.00422077
52MP0005167_abnormal_blood-brain_barrier0.98980267
53MP0002736_abnormal_nociception_after0.98774378
54MP0002233_abnormal_nose_morphology0.98685780
55MP0005171_absent_coat_pigmentation0.98472913
56MP0002876_abnormal_thyroid_physiology0.96984467
57MP0002751_abnormal_autonomic_nervous0.96631400
58MP0006082_CNS_inflammation0.95991102
59MP0005503_abnormal_tendon_morphology0.95882923
60MP0003186_abnormal_redox_activity0.95660542
61MP0004019_abnormal_vitamin_homeostasis0.94886357
62MP0000013_abnormal_adipose_tissue0.92301617
63MP0000427_abnormal_hair_cycle0.91156006
64MP0001963_abnormal_hearing_physiology0.90578166
65MP0004145_abnormal_muscle_electrophysio0.90051960
66MP0000026_abnormal_inner_ear0.89978234
67MP0005360_urolithiasis0.89853997
68MP0005377_hearing/vestibular/ear_phenot0.89696347
69MP0003878_abnormal_ear_physiology0.89696347
70MP0001299_abnormal_eye_distance/0.89428917
71MP0002163_abnormal_gland_morphology0.88610927
72MP0001944_abnormal_pancreas_morphology0.86215028
73MP0004134_abnormal_chest_morphology0.82994181
74MP0003868_abnormal_feces_composition0.82257403
75MP0002210_abnormal_sex_determination0.81618137
76MP0003638_abnormal_response/metabolism_0.81610460
77MP0004147_increased_porphyrin_level0.81552387
78MP0002734_abnormal_mechanical_nocicepti0.81496634
79MP0003698_abnormal_male_reproductive0.81379938
80MP0002837_dystrophic_cardiac_calcinosis0.80698268
81MP0008007_abnormal_cellular_replicative0.78601948
82MP0000653_abnormal_sex_gland0.78284416
83MP0000639_abnormal_adrenal_gland0.78209358
84MP0006276_abnormal_autonomic_nervous0.78009528
85MP0001293_anophthalmia0.77183682
86MP0002735_abnormal_chemical_nociception0.72853435
87MP0006035_abnormal_mitochondrial_morpho0.72507428
88MP0002229_neurodegeneration0.72372133
89MP0003938_abnormal_ear_development0.71815114
90MP0009046_muscle_twitch0.70954940
91MP0001145_abnormal_male_reproductive0.69445233
92MP0000470_abnormal_stomach_morphology0.69108751
93MP0004924_abnormal_behavior0.68430018
94MP0005386_behavior/neurological_phenoty0.68430018
95MP0005220_abnormal_exocrine_pancreas0.68298160
96MP0003786_premature_aging0.64952962
97MP0002572_abnormal_emotion/affect_behav0.63592498
98MP0000383_abnormal_hair_follicle0.63433350
99MP0000049_abnormal_middle_ear0.63246388
100MP0002184_abnormal_innervation0.62488925

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)4.21506603
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.21506603
3Cerebral palsy (HP:0100021)4.17099132
4Stomatitis (HP:0010280)3.95375352
5Acute necrotizing encephalopathy (HP:0006965)3.76619733
6Abnormality of the prostate (HP:0008775)3.58057909
7Absent/shortened dynein arms (HP:0200106)3.53062437
8Dynein arm defect of respiratory motile cilia (HP:0012255)3.53062437
9Acute encephalopathy (HP:0006846)3.30046668
10Progressive macrocephaly (HP:0004481)3.26812527
11Hemoptysis (HP:0002105)3.18240517
12Abnormal mitochondria in muscle tissue (HP:0008316)3.03861776
13Median cleft lip (HP:0000161)3.00946159
14Abnormality of the nasal septum (HP:0000419)2.99449295
15Hypothermia (HP:0002045)2.98092758
16Obstructive lung disease (HP:0006536)2.94491530
17Chronic obstructive pulmonary disease (HP:0006510)2.94491530
18Medial flaring of the eyebrow (HP:0010747)2.89224747
193-Methylglutaconic aciduria (HP:0003535)2.82407100
20Mesomelia (HP:0003027)2.80682689
21Abnormality of the corticospinal tract (HP:0002492)2.80647969
22Ureteral obstruction (HP:0006000)2.63939043
23Cerebral edema (HP:0002181)2.59109667
24Hypoproteinemia (HP:0003075)2.58341800
25Adrenal hypoplasia (HP:0000835)2.55670774
26Increased IgM level (HP:0003496)2.51369176
27Constricted visual fields (HP:0001133)2.47643337
28Colon cancer (HP:0003003)2.43415549
29Abnormality of the pleura (HP:0002103)2.40323678
30Mitochondrial inheritance (HP:0001427)2.39549069
31Congenital stationary night blindness (HP:0007642)2.38008968
32Increased CSF lactate (HP:0002490)2.36801926
33Pancreatic cysts (HP:0001737)2.35424350
34Ureteral stenosis (HP:0000071)2.35121648
35Central scotoma (HP:0000603)2.34683465
36Chin dimple (HP:0010751)2.32432345
37Dyschromatopsia (HP:0007641)2.31023177
38Abnormal rod and cone electroretinograms (HP:0008323)2.29394586
39Large for gestational age (HP:0001520)2.28829185
40Congenital, generalized hypertrichosis (HP:0004540)2.27111486
41Septo-optic dysplasia (HP:0100842)2.26496215
42Congenital primary aphakia (HP:0007707)2.25771452
43Growth hormone deficiency (HP:0000824)2.24954748
44Multiple enchondromatosis (HP:0005701)2.22706189
45Neoplasm of the colon (HP:0100273)2.21852798
46Insulin-resistant diabetes mellitus (HP:0000831)2.21297459
47Abnormal ciliary motility (HP:0012262)2.18911299
48Gait imbalance (HP:0002141)2.15632308
49Nephrogenic diabetes insipidus (HP:0009806)2.12461924
50Aplasia/Hypoplasia of the fovea (HP:0008060)2.10412137
51Hypoplasia of the fovea (HP:0007750)2.10412137
52Type II lissencephaly (HP:0007260)2.09424598
53Supernumerary spleens (HP:0009799)2.07174279
54Hypoplasia of the pons (HP:0012110)2.06833188
55Abnormality of male internal genitalia (HP:0000022)2.05533782
56Aplasia/hypoplasia of the uterus (HP:0008684)2.04632856
57Short phalanx of the thumb (HP:0009660)2.02911522
58Aplastic anemia (HP:0001915)2.01898652
59Hyperinsulinemic hypoglycemia (HP:0000825)2.01372604
60Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.98536301
61Abnormality of alanine metabolism (HP:0010916)1.98536301
62Hyperalaninemia (HP:0003348)1.98536301
63Abnormal respiratory motile cilium physiology (HP:0012261)1.97595479
64Severe muscular hypotonia (HP:0006829)1.97129821
65Decreased electroretinogram (ERG) amplitude (HP:0000654)1.96084394
66Hyperglycemia (HP:0003074)1.96060425
67Absent rod-and cone-mediated responses on ERG (HP:0007688)1.95375393
68Neoplasm of the adrenal cortex (HP:0100641)1.94939704
69Abnormality of the pericardium (HP:0001697)1.93416080
70Abnormal biliary tract physiology (HP:0012439)1.93311121
71Bile duct proliferation (HP:0001408)1.93311121
72Nephronophthisis (HP:0000090)1.91938780
73Decreased central vision (HP:0007663)1.90806334
74Termporal pattern (HP:0011008)1.89931033
75Insidious onset (HP:0003587)1.89931033
76Abnormality of the vasculature of the conjunctiva (HP:0008054)1.89666464
77Abnormal number of erythroid precursors (HP:0012131)1.89388198
78Type 2 muscle fiber atrophy (HP:0003554)1.89150849
79Scotoma (HP:0000575)1.88057395
80Gastrointestinal infarctions (HP:0005244)1.87267206
81Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.86027415
82Depressed nasal tip (HP:0000437)1.85954861
83Optic disc pallor (HP:0000543)1.85083393
84Abnormality of the pons (HP:0007361)1.83958989
85True hermaphroditism (HP:0010459)1.82438799
86Hypomagnesemia (HP:0002917)1.81620550
87Abnormal sex determination (HP:0012244)1.79157728
88Sex reversal (HP:0012245)1.79157728
89Abnormality of the fovea (HP:0000493)1.77426396
90Abnormality of macular pigmentation (HP:0008002)1.76990242
91Bilateral microphthalmos (HP:0007633)1.76731876
92Abnormality of aspartate family amino acid metabolism (HP:0010899)1.76574345
93Impaired vibration sensation in the lower limbs (HP:0002166)1.74624279
94Abnormality of the middle phalanges of the toes (HP:0010183)1.73660194
95Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.73372557
96Short 1st metacarpal (HP:0010034)1.73372557
97IgA deficiency (HP:0002720)1.73328621
98Cerebellar dysplasia (HP:0007033)1.72501823
99Facial cleft (HP:0002006)1.72208439
100Arthropathy (HP:0003040)1.70871365

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.50712400
2NUAK13.35621679
3TIE13.35085716
4MAPKAPK53.04726689
5VRK22.84783054
6ADRBK22.83019184
7FES2.67505029
8EIF2AK32.57503472
9INSRR2.54628320
10BCKDK2.38979859
11NME12.27561985
12STK162.15140395
13MKNK22.11993927
14TAF12.11458772
15TAOK12.09936870
16TAOK32.09629688
17MAP4K22.04436918
18BMPR1B1.93638902
19GRK11.86247259
20PBK1.81311766
21MST41.73618865
22WNK31.73502858
23FER1.63911961
24CSNK1G31.59265420
25TLK11.57543920
26TNIK1.55880605
27PINK11.55050493
28VRK11.49980060
29CSNK1A1L1.44010111
30MKNK11.43661851
31EPHA31.42885905
32CSNK1G11.41828763
33CSNK1G21.29470441
34TSSK61.28228081
35NLK1.25879822
36MYLK1.13919020
37PLK31.11637965
38CDK191.07952529
39DAPK31.04448982
40STK391.00821579
41DYRK20.95404665
42ACVR1B0.92644960
43OXSR10.91840235
44WNK40.90216036
45IKBKB0.88289891
46MAP3K120.86270710
47GRK50.85164904
48PHKG20.84133605
49PHKG10.84133605
50PLK20.84098311
51ZAK0.81484015
52CDK30.77674995
53EIF2AK10.77409206
54PRKCE0.75593553
55RPS6KA50.74273830
56IRAK10.71165758
57TEC0.69929239
58CSNK1A10.68780865
59CDC70.68738911
60DAPK10.65498043
61TNK20.64599393
62BMPR20.63314555
63KIT0.62691672
64PRKG10.61732873
65PLK40.60950975
66PASK0.54281913
67STK110.51564971
68KDR0.50871481
69ILK0.50863458
70MAP3K40.50140075
71PIM10.48664174
72CAMK10.48377271
73ITK0.48329863
74DAPK20.48286919
75PRKCG0.47343382
76TGFBR20.46662415
77CDK80.45069545
78TGFBR10.44254534
79CAMK2A0.42905620
80IRAK30.41060602
81ADRBK10.40545632
82HIPK20.40095354
83LATS10.39543205
84CDK90.39271230
85PRKCA0.37956630
86CSNK2A20.37598745
87EIF2AK20.36652350
88PRKACA0.34664555
89AURKA0.34326949
90CSNK1E0.33759578
91PLK10.33635607
92TRIM280.33327534
93MAP3K90.32511058
94EPHA40.30752496
95CSNK2A10.30434976
96OBSCN0.30137865
97FGFR20.30030830
98RPS6KB20.24937640
99PRKCD0.24100397
100MAP2K60.20922373

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053105.40982183
2Allograft rejection_Homo sapiens_hsa053304.29759863
3Autoimmune thyroid disease_Homo sapiens_hsa053204.05208573
4Intestinal immune network for IgA production_Homo sapiens_hsa046723.94257727
5Protein export_Homo sapiens_hsa030603.07091854
6Maturity onset diabetes of the young_Homo sapiens_hsa049502.92653668
7Graft-versus-host disease_Homo sapiens_hsa053322.78709588
8Type I diabetes mellitus_Homo sapiens_hsa049402.72812349
9Oxidative phosphorylation_Homo sapiens_hsa001902.52877042
10Proteasome_Homo sapiens_hsa030502.44223042
11RNA polymerase_Homo sapiens_hsa030202.12950051
12Rheumatoid arthritis_Homo sapiens_hsa053232.12471548
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.11804704
14Antigen processing and presentation_Homo sapiens_hsa046121.95661462
15Basal transcription factors_Homo sapiens_hsa030221.93402810
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.91632319
17Parkinsons disease_Homo sapiens_hsa050121.81720069
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.79811510
19Ribosome_Homo sapiens_hsa030101.79567703
20Staphylococcus aureus infection_Homo sapiens_hsa051501.57712053
21Phototransduction_Homo sapiens_hsa047441.56165321
22Collecting duct acid secretion_Homo sapiens_hsa049661.53738328
23Homologous recombination_Homo sapiens_hsa034401.42331561
24Viral myocarditis_Homo sapiens_hsa054161.31910167
25Mismatch repair_Homo sapiens_hsa034301.31315624
26Caffeine metabolism_Homo sapiens_hsa002321.16243327
27Huntingtons disease_Homo sapiens_hsa050161.09982720
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.06741934
29Alzheimers disease_Homo sapiens_hsa050101.05500476
30Cardiac muscle contraction_Homo sapiens_hsa042601.04609585
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.03776680
32RNA degradation_Homo sapiens_hsa030181.03432746
33Systemic lupus erythematosus_Homo sapiens_hsa053220.98014138
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97917102
35Sulfur metabolism_Homo sapiens_hsa009200.96344594
36Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.96082998
37Linoleic acid metabolism_Homo sapiens_hsa005910.93042921
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.90837192
39RNA transport_Homo sapiens_hsa030130.89160376
40SNARE interactions in vesicular transport_Homo sapiens_hsa041300.88103999
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.86657028
42Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.82838441
43Leishmaniasis_Homo sapiens_hsa051400.80766918
44Pyrimidine metabolism_Homo sapiens_hsa002400.80511828
45Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.79572509
46Primary bile acid biosynthesis_Homo sapiens_hsa001200.79404223
47Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.77241407
48Tryptophan metabolism_Homo sapiens_hsa003800.75592470
49Spliceosome_Homo sapiens_hsa030400.75472163
50Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.73163076
51Nicotine addiction_Homo sapiens_hsa050330.72969230
52Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.68569626
53Vitamin B6 metabolism_Homo sapiens_hsa007500.66458076
54Chemical carcinogenesis_Homo sapiens_hsa052040.66439962
55Primary immunodeficiency_Homo sapiens_hsa053400.62648567
56Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62643368
57Retinol metabolism_Homo sapiens_hsa008300.59391169
58Cysteine and methionine metabolism_Homo sapiens_hsa002700.59185508
59Steroid hormone biosynthesis_Homo sapiens_hsa001400.59033298
60Non-homologous end-joining_Homo sapiens_hsa034500.57693554
61Olfactory transduction_Homo sapiens_hsa047400.55680213
62Phagosome_Homo sapiens_hsa041450.53553653
63DNA replication_Homo sapiens_hsa030300.52592117
64Peroxisome_Homo sapiens_hsa041460.51700028
65Regulation of autophagy_Homo sapiens_hsa041400.51446719
66Arachidonic acid metabolism_Homo sapiens_hsa005900.50442320
67alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.49534344
68Nucleotide excision repair_Homo sapiens_hsa034200.47924530
69GABAergic synapse_Homo sapiens_hsa047270.47469988
70Purine metabolism_Homo sapiens_hsa002300.46682802
71Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45554578
72Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.45409482
73Propanoate metabolism_Homo sapiens_hsa006400.42938501
74Hematopoietic cell lineage_Homo sapiens_hsa046400.41259644
75Ether lipid metabolism_Homo sapiens_hsa005650.40841388
76Synaptic vesicle cycle_Homo sapiens_hsa047210.40594583
77Epstein-Barr virus infection_Homo sapiens_hsa051690.39808995
78Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.35761780
79Fanconi anemia pathway_Homo sapiens_hsa034600.35681608
80Taste transduction_Homo sapiens_hsa047420.35338157
81Metabolic pathways_Homo sapiens_hsa011000.35152793
82Ovarian steroidogenesis_Homo sapiens_hsa049130.33920589
83Pyruvate metabolism_Homo sapiens_hsa006200.33619381
84Toxoplasmosis_Homo sapiens_hsa051450.31087658
85Nitrogen metabolism_Homo sapiens_hsa009100.29810895
86Mineral absorption_Homo sapiens_hsa049780.28389174
87Herpes simplex infection_Homo sapiens_hsa051680.27519495
88Base excision repair_Homo sapiens_hsa034100.26037338
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.25696366
90Oocyte meiosis_Homo sapiens_hsa041140.25573262
91Selenocompound metabolism_Homo sapiens_hsa004500.24794747
92Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.24658135
93Glutathione metabolism_Homo sapiens_hsa004800.23964662
94Serotonergic synapse_Homo sapiens_hsa047260.23589560
95Hedgehog signaling pathway_Homo sapiens_hsa043400.21843417
96One carbon pool by folate_Homo sapiens_hsa006700.21544624
97Histidine metabolism_Homo sapiens_hsa003400.21443583
98Vitamin digestion and absorption_Homo sapiens_hsa049770.20746208
99Influenza A_Homo sapiens_hsa051640.17182794
100Renin-angiotensin system_Homo sapiens_hsa046140.16899071

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