BTF3P11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1signal peptide processing (GO:0006465)7.19366279
2ribosomal small subunit biogenesis (GO:0042274)6.81342500
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.12180933
4ATP synthesis coupled proton transport (GO:0015986)5.95175690
5energy coupled proton transport, down electrochemical gradient (GO:0015985)5.95175690
6viral transcription (GO:0019083)5.47908203
7protein prenylation (GO:0018342)5.44230398
8prenylation (GO:0097354)5.44230398
9ribosomal large subunit biogenesis (GO:0042273)5.33510276
10translational termination (GO:0006415)5.26182521
11cytochrome complex assembly (GO:0017004)5.07584890
12L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.91603393
13GTP biosynthetic process (GO:0006183)4.88438953
14translational elongation (GO:0006414)4.86694043
15SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.84672302
16valine metabolic process (GO:0006573)4.81662067
17respiratory chain complex IV assembly (GO:0008535)4.75787166
18cotranslational protein targeting to membrane (GO:0006613)4.74236184
19protein targeting to ER (GO:0045047)4.73714318
20chaperone-mediated protein transport (GO:0072321)4.59331346
21DNA deamination (GO:0045006)4.58754415
22ribosomal small subunit assembly (GO:0000028)4.55954088
23branched-chain amino acid catabolic process (GO:0009083)4.51919055
24establishment of protein localization to endoplasmic reticulum (GO:0072599)4.45444304
25respiratory electron transport chain (GO:0022904)4.42362274
26protein localization to endoplasmic reticulum (GO:0070972)4.39565767
27electron transport chain (GO:0022900)4.35449939
28mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.30193475
29L-methionine salvage (GO:0071267)4.24919749
30L-methionine biosynthetic process (GO:0071265)4.24919749
31amino acid salvage (GO:0043102)4.24919749
32UTP biosynthetic process (GO:0006228)4.21204254
33UTP metabolic process (GO:0046051)4.06939522
34pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.04438893
35protein complex biogenesis (GO:0070271)3.96814050
36cellular protein complex disassembly (GO:0043624)3.95731738
37translation (GO:0006412)3.90572948
38translational initiation (GO:0006413)3.88222323
39nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.88060208
40viral life cycle (GO:0019058)3.86479410
41purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.82823167
42mitochondrial respiratory chain complex assembly (GO:0033108)3.79539026
43maturation of 5.8S rRNA (GO:0000460)3.79514858
44maturation of SSU-rRNA (GO:0030490)3.79369596
45pseudouridine synthesis (GO:0001522)3.77123092
46purine nucleoside triphosphate biosynthetic process (GO:0009145)3.75679026
47ribonucleoprotein complex biogenesis (GO:0022613)3.71889082
48guanosine-containing compound biosynthetic process (GO:1901070)3.69331128
49regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.67214822
50exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.61713840
51seminiferous tubule development (GO:0072520)3.61385969
52pyrimidine nucleotide catabolic process (GO:0006244)3.57875057
53rRNA modification (GO:0000154)3.56148998
54regulation of translation in response to stress (GO:0043555)3.52678163
55branched-chain amino acid metabolic process (GO:0009081)3.51799485
56proteasome assembly (GO:0043248)3.49547552
57nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.49519060
58ATP biosynthetic process (GO:0006754)3.49470814
59pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.47423079
60regulation of podosome assembly (GO:0071801)3.47012317
61cellular component biogenesis (GO:0044085)3.43370396
62mitochondrion transport along microtubule (GO:0047497)3.41833685
63establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.41833685
64methionine biosynthetic process (GO:0009086)3.39243316
65CTP metabolic process (GO:0046036)3.34522610
66CTP biosynthetic process (GO:0006241)3.34522610
67ribonucleoside triphosphate biosynthetic process (GO:0009201)3.31806485
68regulation of mitochondrial translation (GO:0070129)3.27540760
69pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.24505645
70establishment of protein localization to mitochondrial membrane (GO:0090151)3.24305494
71cardiovascular system development (GO:0072358)3.22111755
72purine nucleotide salvage (GO:0032261)3.19683103
73rRNA methylation (GO:0031167)3.18725194
74cytokinetic process (GO:0032506)3.18440167
75hydrogen ion transmembrane transport (GO:1902600)3.16140529
76protein targeting to membrane (GO:0006612)3.14362712
77oxidative phosphorylation (GO:0006119)3.12838123
78protein complex disassembly (GO:0043241)3.11773473
79protein maturation by protein folding (GO:0022417)3.09874235
80pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.09071194
81RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.05043475
82tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.05043475
83protein targeting to mitochondrion (GO:0006626)3.02380248
84nuclear-transcribed mRNA catabolic process (GO:0000956)3.02299859
85establishment of mitochondrion localization (GO:0051654)3.01743309
86nucleoside diphosphate phosphorylation (GO:0006165)3.00232181
87nucleoside triphosphate biosynthetic process (GO:0009142)2.98338440
88deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.96983699
89negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.96307378
90protein neddylation (GO:0045116)2.96088348
91pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.94515125
92negative regulation of membrane potential (GO:0045837)2.94194224
93mast cell activation involved in immune response (GO:0002279)2.92638817
94mast cell degranulation (GO:0043303)2.92638817
95proton transport (GO:0015992)2.91228149
96pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.90672118
97NADH dehydrogenase complex assembly (GO:0010257)2.90458339
98mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.90458339
99mitochondrial respiratory chain complex I assembly (GO:0032981)2.90458339
100negative regulation of heart rate (GO:0010459)2.90221641

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.36137427
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.35522169
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.64675341
4EST1_17652178_ChIP-ChIP_JURKAT_Human4.29455047
5ELF1_17652178_ChIP-ChIP_JURKAT_Human4.10888418
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.08211934
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.27997611
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.02434663
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.02087048
10MYC_18555785_ChIP-Seq_MESCs_Mouse3.01181796
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.82472120
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.68761945
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.66497377
14VDR_23849224_ChIP-Seq_CD4+_Human2.64182663
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.42160461
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.41556757
17PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.37824561
18VDR_22108803_ChIP-Seq_LS180_Human2.32361858
19EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.28423760
20FOXP3_21729870_ChIP-Seq_TREG_Human2.27629829
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.21533294
22MYC_18358816_ChIP-ChIP_MESCs_Mouse2.20050560
23YY1_21170310_ChIP-Seq_MESCs_Mouse2.18166054
24CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.06931200
25SRF_21415370_ChIP-Seq_HL-1_Mouse2.03079503
26ELK1_19687146_ChIP-ChIP_HELA_Human1.87558160
27PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.80718344
28ZNF274_21170338_ChIP-Seq_K562_Hela1.78609361
29FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.77566586
30CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.77170253
31BP1_19119308_ChIP-ChIP_Hs578T_Human1.73089141
32XRN2_22483619_ChIP-Seq_HELA_Human1.67482485
33THAP11_20581084_ChIP-Seq_MESCs_Mouse1.63818515
34MYC_19079543_ChIP-ChIP_MESCs_Mouse1.58429872
35DCP1A_22483619_ChIP-Seq_HELA_Human1.57216509
36POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.53012827
37SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.52176557
38E2F7_22180533_ChIP-Seq_HELA_Human1.51285143
39MYC_19030024_ChIP-ChIP_MESCs_Mouse1.48279571
40PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.48220205
41TTF2_22483619_ChIP-Seq_HELA_Human1.43176596
42HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.40778531
43E2F1_18555785_ChIP-Seq_MESCs_Mouse1.39445281
44SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.38792364
45TP53_22573176_ChIP-Seq_HFKS_Human1.38752857
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.29501782
47FLI1_27457419_Chip-Seq_LIVER_Mouse1.25443191
48EGR1_23403033_ChIP-Seq_LIVER_Mouse1.24937261
49CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.23010218
50IRF8_22096565_ChIP-ChIP_GC-B_Human1.22705560
51AR_21572438_ChIP-Seq_LNCaP_Human1.21700332
52HOXB4_20404135_ChIP-ChIP_EML_Mouse1.20497052
53ERG_20517297_ChIP-Seq_VCAP_Human1.19679611
54GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.16330362
55ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.15465617
56TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.14666259
57HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.14267328
58GABP_19822575_ChIP-Seq_HepG2_Human1.13776050
59BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.12211796
60TAF2_19829295_ChIP-Seq_ESCs_Human1.10304472
61PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10303718
62STAT4_19710469_ChIP-ChIP_TH1__Mouse1.10280949
63EWS_26573619_Chip-Seq_HEK293_Human1.09679247
64POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.08108931
65CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.05020026
66MYB_26560356_Chip-Seq_TH2_Human1.03034895
67AUTS2_25519132_ChIP-Seq_293T-REX_Human1.02938757
68NANOG_20526341_ChIP-Seq_ESCs_Human1.01301888
69AR_20517297_ChIP-Seq_VCAP_Human1.00091424
70MYC_18940864_ChIP-ChIP_HL60_Human0.98859657
71FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.97155041
72FOXA1_27270436_Chip-Seq_PROSTATE_Human0.96332137
73FOXA1_25329375_ChIP-Seq_VCAP_Human0.96332137
74FOXH1_21741376_ChIP-Seq_EPCs_Human0.95881579
75POU5F1_16153702_ChIP-ChIP_HESCs_Human0.95712553
76FOXA1_21572438_ChIP-Seq_LNCaP_Human0.94727652
77ELK1_22589737_ChIP-Seq_MCF10A_Human0.94072614
78PCGF2_27294783_Chip-Seq_ESCs_Mouse0.91677005
79SOX2_18555785_ChIP-Seq_MESCs_Mouse0.90536310
80EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.90345533
81BMI1_23680149_ChIP-Seq_NPCS_Mouse0.89761414
82GATA3_21878914_ChIP-Seq_MCF-7_Human0.89457125
83NANOG_19829295_ChIP-Seq_ESCs_Human0.88725492
84SOX2_19829295_ChIP-Seq_ESCs_Human0.88725492
85MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.87768056
86LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.87711371
87ERA_21632823_ChIP-Seq_H3396_Human0.86690026
88BCL6_27268052_Chip-Seq_Bcells_Human0.86637873
89EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.84011826
90KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.82855854
91NANOG_18555785_ChIP-Seq_MESCs_Mouse0.82357432
92NCOR_22424771_ChIP-Seq_293T_Human0.81235036
93SPI1_23547873_ChIP-Seq_NB4_Human0.80395076
94ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.79958873
95FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79583484
96FOXH1_21741376_ChIP-Seq_ESCs_Human0.77732276
97KDM5A_27292631_Chip-Seq_BREAST_Human0.77224777
98SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.77167749
99GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.77164979
100SOX2_21211035_ChIP-Seq_LN229_Human0.76987633

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation8.28258810
2MP0005671_abnormal_response_to3.87749079
3MP0003646_muscle_fatigue3.72378786
4MP0005397_hematopoietic_system_phenotyp2.93393608
5MP0001545_abnormal_hematopoietic_system2.93393608
6MP0004145_abnormal_muscle_electrophysio2.50702834
7MP0001873_stomach_inflammation2.39157554
8MP0001835_abnormal_antigen_presentation2.36528336
9MP0004858_abnormal_nervous_system2.19944584
10MP0002163_abnormal_gland_morphology2.19271621
11MP0008058_abnormal_DNA_repair2.01933378
12MP0000685_abnormal_immune_system1.88558614
13MP0005645_abnormal_hypothalamus_physiol1.88160260
14MP0008875_abnormal_xenobiotic_pharmacok1.84905497
15MP0003880_abnormal_central_pattern1.83661493
16MP0008789_abnormal_olfactory_epithelium1.81552603
17MP0002837_dystrophic_cardiac_calcinosis1.73905582
18MP0006072_abnormal_retinal_apoptosis1.70311261
19MP0005503_abnormal_tendon_morphology1.60715227
20MP0005387_immune_system_phenotype1.59488741
21MP0001790_abnormal_immune_system1.59488741
22MP0001529_abnormal_vocalization1.59471058
23MP0002102_abnormal_ear_morphology1.58735281
24MP0002095_abnormal_skin_pigmentation1.54542431
25MP0002277_abnormal_respiratory_mucosa1.53554145
26MP0009785_altered_susceptibility_to1.53514809
27MP0008872_abnormal_physiological_respon1.52599274
28MP0003693_abnormal_embryo_hatching1.52243080
29MP0001800_abnormal_humoral_immune1.50316886
30MP0006036_abnormal_mitochondrial_physio1.48088442
31MP0001919_abnormal_reproductive_system1.46577633
32MP0003718_maternal_effect1.39869543
33MP0002638_abnormal_pupillary_reflex1.38345058
34MP0003195_calcinosis1.37095438
35MP0003011_delayed_dark_adaptation1.35659579
36MP0005379_endocrine/exocrine_gland_phen1.35406318
37MP0005360_urolithiasis1.32359723
38MP0003763_abnormal_thymus_physiology1.29566741
39MP0005389_reproductive_system_phenotype1.25441943
40MP0003724_increased_susceptibility_to1.24838199
41MP0009333_abnormal_splenocyte_physiolog1.24811404
42MP0003866_abnormal_defecation1.22398569
43MP0005551_abnormal_eye_electrophysiolog1.19103159
44MP0004957_abnormal_blastocyst_morpholog1.13077883
45MP0008877_abnormal_DNA_methylation1.12809666
46MP0005000_abnormal_immune_tolerance1.12746476
47MP0001853_heart_inflammation1.10258013
48MP0001348_abnormal_lacrimal_gland1.10197605
49MP0005636_abnormal_mineral_homeostasis1.08929912
50MP0002723_abnormal_immune_serum1.08360917
51MP0006082_CNS_inflammation1.06711354
52MP0003186_abnormal_redox_activity1.06217240
53MP0002736_abnormal_nociception_after1.04941939
54MP0002148_abnormal_hypersensitivity_rea1.04880136
55MP0001663_abnormal_digestive_system1.02399523
56MP0005085_abnormal_gallbladder_physiolo1.02294232
57MP0002420_abnormal_adaptive_immunity1.00216419
58MP0002132_abnormal_respiratory_system0.99993775
59MP0005025_abnormal_response_to0.98937485
60MP0003786_premature_aging0.98121547
61MP0002160_abnormal_reproductive_system0.97569583
62MP0001819_abnormal_immune_cell0.96747583
63MP0002452_abnormal_antigen_presenting0.95039806
64MP0000569_abnormal_digit_pigmentation0.92836155
65MP0005410_abnormal_fertilization0.91479161
66MP0004885_abnormal_endolymph0.86051973
67MP0005174_abnormal_tail_pigmentation0.85947757
68MP0002938_white_spotting0.85734796
69MP0005499_abnormal_olfactory_system0.84800042
70MP0005394_taste/olfaction_phenotype0.84800042
71MP0004147_increased_porphyrin_level0.84577725
72MP0000049_abnormal_middle_ear0.83891732
73MP0005332_abnormal_amino_acid0.80219347
74MP0001845_abnormal_inflammatory_respons0.79482700
75MP0000858_altered_metastatic_potential0.75689773
76MP0008995_early_reproductive_senescence0.75533304
77MP0000716_abnormal_immune_system0.73923265
78MP0008932_abnormal_embryonic_tissue0.73162326
79MP0002398_abnormal_bone_marrow0.72626135
80MP0001905_abnormal_dopamine_level0.72102278
81MP0000372_irregular_coat_pigmentation0.71082890
82MP0009046_muscle_twitch0.69010919
83MP0010155_abnormal_intestine_physiology0.68657626
84MP0001119_abnormal_female_reproductive0.67822278
85MP0005381_digestive/alimentary_phenotyp0.65255635
86MP0005646_abnormal_pituitary_gland0.64925515
87MP0001968_abnormal_touch/_nociception0.64842790
88MP0003638_abnormal_response/metabolism_0.64519347
89MP0002210_abnormal_sex_determination0.64259565
90MP0006035_abnormal_mitochondrial_morpho0.63202281
91MP0005377_hearing/vestibular/ear_phenot0.63079318
92MP0003878_abnormal_ear_physiology0.63079318
93MP0005670_abnormal_white_adipose0.62274002
94MP0002429_abnormal_blood_cell0.62087093
95MP0001765_abnormal_ion_homeostasis0.61869830
96MP0001756_abnormal_urination0.60909965
97MP0005395_other_phenotype0.59751535
98MP0000477_abnormal_intestine_morphology0.59625149
99MP0002166_altered_tumor_susceptibility0.59326070
100MP0004782_abnormal_surfactant_physiolog0.59295901

Predicted human phenotypes

RankGene SetZ-score
1Absent rod-and cone-mediated responses on ERG (HP:0007688)6.85994723
2Decreased central vision (HP:0007663)5.55743198
3Pendular nystagmus (HP:0012043)5.52338352
4Abnormal rod and cone electroretinograms (HP:0008323)4.64618023
5Acute necrotizing encephalopathy (HP:0006965)4.53505148
6Acanthocytosis (HP:0001927)4.48285851
7Disinhibition (HP:0000734)4.32436637
8Mitochondrial inheritance (HP:0001427)4.19152173
9Abnormal mitochondria in muscle tissue (HP:0008316)4.10660418
10Cerebral hypomyelination (HP:0006808)4.07705669
11Self-mutilation (HP:0000742)4.07371225
12Increased CSF lactate (HP:0002490)4.03142689
13Personality changes (HP:0000751)3.86239272
14Progressive macrocephaly (HP:0004481)3.85393772
15Acute encephalopathy (HP:0006846)3.78693613
16Hepatocellular necrosis (HP:0001404)3.64977644
17Acute hepatic failure (HP:0006554)3.57889344
18Attenuation of retinal blood vessels (HP:0007843)3.53802490
19Increased hepatocellular lipid droplets (HP:0006565)3.49713889
20Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.29209629
21Abnormality of alanine metabolism (HP:0010916)3.29209629
22Hyperalaninemia (HP:0003348)3.29209629
23Increased corneal curvature (HP:0100692)3.28934862
24Keratoconus (HP:0000563)3.28934862
25Hepatic necrosis (HP:0002605)3.23198195
26Cerebral edema (HP:0002181)3.19668218
273-Methylglutaconic aciduria (HP:0003535)3.15110737
28Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.07587730
29Decreased activity of mitochondrial respiratory chain (HP:0008972)3.07587730
30Aplastic anemia (HP:0001915)3.06752668
31Increased serum lactate (HP:0002151)2.99464522
32Optic disc pallor (HP:0000543)2.97002083
33Increased intramyocellular lipid droplets (HP:0012240)2.96049868
34Lipid accumulation in hepatocytes (HP:0006561)2.87515756
35Renal Fanconi syndrome (HP:0001994)2.82474564
36Exertional dyspnea (HP:0002875)2.82074696
37Dyskinesia (HP:0100660)2.75393138
38Inappropriate behavior (HP:0000719)2.62423637
39Carpal bone hypoplasia (HP:0001498)2.60571848
40Hypothermia (HP:0002045)2.60526933
41Lactic acidosis (HP:0003128)2.58244505
42Stomatitis (HP:0010280)2.54813442
43Macrocytic anemia (HP:0001972)2.52927225
44CNS hypomyelination (HP:0003429)2.47708467
45Pallor (HP:0000980)2.47072146
46IgG deficiency (HP:0004315)2.42238731
47Unsteady gait (HP:0002317)2.41218146
48Respiratory failure (HP:0002878)2.39350625
49CNS demyelination (HP:0007305)2.37160823
50Respiratory difficulties (HP:0002880)2.36455786
51Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.34419150
52Elevated erythrocyte sedimentation rate (HP:0003565)2.33789411
53Increased muscle lipid content (HP:0009058)2.28967880
54Hyperphosphaturia (HP:0003109)2.28387255
55Degeneration of the lateral corticospinal tracts (HP:0002314)2.21842262
56Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.21842262
57Agitation (HP:0000713)2.19600677
58Choreoathetosis (HP:0001266)2.18640768
59Irregular epiphyses (HP:0010582)2.16028016
60Lethargy (HP:0001254)2.12878500
61Abnormal number of erythroid precursors (HP:0012131)2.12556091
62Chronic bronchitis (HP:0004469)2.11738558
63Delayed CNS myelination (HP:0002188)2.06136146
64Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.04920504
65Congenital stationary night blindness (HP:0007642)2.03460157
66Exercise intolerance (HP:0003546)2.00417978
67Microretrognathia (HP:0000308)1.99052210
68Abnormality of cells of the erythroid lineage (HP:0012130)1.97674944
69Premature ovarian failure (HP:0008209)1.96753087
70Cleft eyelid (HP:0000625)1.96136138
71Leukodystrophy (HP:0002415)1.95301434
72Hypoalbuminemia (HP:0003073)1.93370983
73Abnormal albumin level (HP:0012116)1.93370983
74Emotional lability (HP:0000712)1.93056336
75Constricted visual fields (HP:0001133)1.89299406
76Limb hypertonia (HP:0002509)1.88887097
77Type 2 muscle fiber atrophy (HP:0003554)1.84831655
78Macular degeneration (HP:0000608)1.84302979
79Reticulocytopenia (HP:0001896)1.78684390
80Abnormality of serum amino acid levels (HP:0003112)1.77801632
81Abnormality of renal resorption (HP:0011038)1.77765882
82Type II lissencephaly (HP:0007260)1.75073162
83Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.74491793
84Oligomenorrhea (HP:0000876)1.73988230
85Progressive microcephaly (HP:0000253)1.73285596
86Secondary amenorrhea (HP:0000869)1.71035985
87Psychosis (HP:0000709)1.70893999
88Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.70470237
89Poikilocytosis (HP:0004447)1.69823465
90Generalized aminoaciduria (HP:0002909)1.67861995
91Abnormal urine phosphate concentration (HP:0012599)1.67252247
92Severe muscular hypotonia (HP:0006829)1.67115427
93Muscle fiber atrophy (HP:0100295)1.66501401
94Rectovaginal fistula (HP:0000143)1.64903355
95Rectal fistula (HP:0100590)1.64903355
96Vasculitis (HP:0002633)1.64205221
97Hypoproteinemia (HP:0003075)1.60193587
98Memory impairment (HP:0002354)1.58607193
99Abnormality of urine glucose concentration (HP:0011016)1.57698974
100Glycosuria (HP:0003076)1.57698974

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME26.59779431
2BMPR24.97840311
3MUSK4.05064282
4BCKDK3.30005573
5TXK2.78903134
6RIPK42.75633459
7VRK22.60954647
8CDK192.45964397
9GRK12.37665284
10NUAK12.37151735
11TIE12.31575017
12MAP4K12.30166855
13TLK11.99194616
14KDR1.98161883
15MST41.92707221
16WNK31.91521399
17BUB11.81054628
18ADRBK21.54583683
19PDK21.51824549
20TAOK31.47208041
21ZAK1.44975613
22VRK11.25245852
23NME11.18554655
24IKBKB1.10412898
25EPHA31.07867176
26CDC71.07187948
27LRRK21.05331291
28PBK1.04644291
29TSSK61.04596527
30DYRK21.02716795
31OXSR11.01367154
32ITK0.95732698
33PIK3CG0.93775698
34INSRR0.88736025
35RPS6KA50.86715563
36PLK40.85857324
37MYLK0.79612198
38TEC0.78637267
39FRK0.76390550
40CDK40.73257833
41OBSCN0.70657571
42LCK0.69857244
43GRK60.69683382
44WNK40.69325735
45BTK0.68395605
46ACVR1B0.67682208
47DAPK10.67555344
48CSNK2A10.65797316
49CSK0.65134565
50SYK0.65013043
51FES0.62966881
52MAP4K20.62879949
53GRK50.61124806
54JAK30.60514147
55BMPR1B0.57995295
56PRKCG0.55890141
57MAP3K130.55886484
58CSNK2A20.54544236
59MAP3K90.52911313
60GRK70.50489388
61PRKACA0.50412658
62PLK30.49585972
63KIT0.48652276
64ADRBK10.45492160
65ABL20.45457442
66PASK0.44340900
67ARAF0.43819658
68PIM20.43212314
69AURKA0.41306073
70PLK10.41157196
71TGFBR10.41057002
72CSF1R0.41056705
73MAP3K40.40891613
74TAF10.40064542
75AURKB0.39777763
76ILK0.39294206
77MAP3K120.37049580
78PRKCA0.36067258
79PRKCB0.35800394
80IKBKE0.35616061
81TESK20.35506939
82CDK80.34047622
83ALK0.33242652
84PHKG10.32577086
85PHKG20.32577086
86NEK10.31613739
87DAPK30.29598676
88PRKCQ0.29260001
89PRKG10.27593175
90PRKACG0.27531535
91SRPK10.26666726
92CAMK2A0.25995330
93STK110.25916348
94PIM10.25898657
95CDK70.25457490
96MAPKAPK50.25356246
97PRKCI0.25056188
98MOS0.24537985
99RPS6KA40.24375844
100CHEK20.23634174

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.02468892
2Oxidative phosphorylation_Homo sapiens_hsa001904.15807902
3Asthma_Homo sapiens_hsa053103.93787079
4Allograft rejection_Homo sapiens_hsa053303.27793698
5Parkinsons disease_Homo sapiens_hsa050123.25210340
6Proteasome_Homo sapiens_hsa030503.23926907
7Autoimmune thyroid disease_Homo sapiens_hsa053203.22169003
8Intestinal immune network for IgA production_Homo sapiens_hsa046723.04049047
9Graft-versus-host disease_Homo sapiens_hsa053322.34003396
10Alzheimers disease_Homo sapiens_hsa050102.27813258
11RNA polymerase_Homo sapiens_hsa030202.20731677
12Huntingtons disease_Homo sapiens_hsa050162.19821310
13Protein export_Homo sapiens_hsa030602.19087618
14Type I diabetes mellitus_Homo sapiens_hsa049402.02975086
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.01198261
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.91984344
17One carbon pool by folate_Homo sapiens_hsa006701.86257259
18Cardiac muscle contraction_Homo sapiens_hsa042601.81839091
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.66308489
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.65460762
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.63342465
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.59447697
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.58203410
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.55652003
25Rheumatoid arthritis_Homo sapiens_hsa053231.52820293
26Primary immunodeficiency_Homo sapiens_hsa053401.52324936
27Antigen processing and presentation_Homo sapiens_hsa046121.44259663
28RNA degradation_Homo sapiens_hsa030181.32290518
29Sulfur relay system_Homo sapiens_hsa041221.30812063
30Phototransduction_Homo sapiens_hsa047441.12894775
31Hematopoietic cell lineage_Homo sapiens_hsa046401.09921504
32Pyrimidine metabolism_Homo sapiens_hsa002401.08797780
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.07978652
34Viral myocarditis_Homo sapiens_hsa054161.07729831
35DNA replication_Homo sapiens_hsa030301.06558565
36Basal transcription factors_Homo sapiens_hsa030220.98559958
37Homologous recombination_Homo sapiens_hsa034400.96432270
38Collecting duct acid secretion_Homo sapiens_hsa049660.96190763
39Staphylococcus aureus infection_Homo sapiens_hsa051500.92017739
40Selenocompound metabolism_Homo sapiens_hsa004500.89942226
41Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.84904005
42Nitrogen metabolism_Homo sapiens_hsa009100.81700886
43Purine metabolism_Homo sapiens_hsa002300.80393776
44RNA transport_Homo sapiens_hsa030130.78922283
45Base excision repair_Homo sapiens_hsa034100.78003688
46Sulfur metabolism_Homo sapiens_hsa009200.77852179
47Leishmaniasis_Homo sapiens_hsa051400.74317757
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.68068049
49Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.66694443
50Systemic lupus erythematosus_Homo sapiens_hsa053220.65965242
51Vitamin B6 metabolism_Homo sapiens_hsa007500.65507802
52Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.64827565
53SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62547137
54Linoleic acid metabolism_Homo sapiens_hsa005910.60536363
55Metabolic pathways_Homo sapiens_hsa011000.58736060
56Retinol metabolism_Homo sapiens_hsa008300.58107737
57Olfactory transduction_Homo sapiens_hsa047400.56975877
58Maturity onset diabetes of the young_Homo sapiens_hsa049500.56437508
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56189143
60Spliceosome_Homo sapiens_hsa030400.55762841
61T cell receptor signaling pathway_Homo sapiens_hsa046600.52019450
62NF-kappa B signaling pathway_Homo sapiens_hsa040640.48181189
63Fanconi anemia pathway_Homo sapiens_hsa034600.47955613
64Tryptophan metabolism_Homo sapiens_hsa003800.47919592
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.47096413
66Arachidonic acid metabolism_Homo sapiens_hsa005900.47060604
67Pyruvate metabolism_Homo sapiens_hsa006200.44317519
68Pancreatic secretion_Homo sapiens_hsa049720.39546972
69Nucleotide excision repair_Homo sapiens_hsa034200.37425743
70Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.37355914
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.36641406
72Chemical carcinogenesis_Homo sapiens_hsa052040.35177543
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.34372247
74Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.32288116
75Tyrosine metabolism_Homo sapiens_hsa003500.31777739
76Drug metabolism - other enzymes_Homo sapiens_hsa009830.31386531
77Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.31253315
78Cysteine and methionine metabolism_Homo sapiens_hsa002700.30856385
79alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30212811
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.29408436
81Primary bile acid biosynthesis_Homo sapiens_hsa001200.29316039
82Phagosome_Homo sapiens_hsa041450.28904473
83Mismatch repair_Homo sapiens_hsa034300.27262227
84Glycerophospholipid metabolism_Homo sapiens_hsa005640.26553418
85Fat digestion and absorption_Homo sapiens_hsa049750.25446493
86Mineral absorption_Homo sapiens_hsa049780.24046203
87Herpes simplex infection_Homo sapiens_hsa051680.22886255
88Peroxisome_Homo sapiens_hsa041460.22679020
89Folate biosynthesis_Homo sapiens_hsa007900.21747236
90Propanoate metabolism_Homo sapiens_hsa006400.21298768
91Epstein-Barr virus infection_Homo sapiens_hsa051690.16671415
92Malaria_Homo sapiens_hsa051440.15702196
93Salivary secretion_Homo sapiens_hsa049700.14330925
94Glutathione metabolism_Homo sapiens_hsa004800.13934535
95Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.13912868
96Renin-angiotensin system_Homo sapiens_hsa046140.13638814
97Pentose and glucuronate interconversions_Homo sapiens_hsa000400.12351368
98Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.12284652
99Ether lipid metabolism_Homo sapiens_hsa005650.11676778
100Arginine biosynthesis_Homo sapiens_hsa002200.11079098

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