BTF3L4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein neddylation (GO:0045116)4.70263512
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.68406263
3energy coupled proton transport, down electrochemical gradient (GO:0015985)4.26455156
4ATP synthesis coupled proton transport (GO:0015986)4.26455156
5chaperone-mediated protein transport (GO:0072321)4.14858651
6cullin deneddylation (GO:0010388)4.09090420
7protein deneddylation (GO:0000338)3.86096701
8pyrimidine nucleobase catabolic process (GO:0006208)3.77319731
9proteasome assembly (GO:0043248)3.60935191
10establishment of integrated proviral latency (GO:0075713)3.56783645
11CENP-A containing nucleosome assembly (GO:0034080)3.38645967
12mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.35006706
13chromatin remodeling at centromere (GO:0031055)3.29644791
14negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.29029029
15regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.28202839
16regulation of mitotic spindle checkpoint (GO:1903504)3.28202839
17spliceosomal complex assembly (GO:0000245)3.26311369
18ribosomal small subunit biogenesis (GO:0042274)3.25083541
197-methylguanosine mRNA capping (GO:0006370)3.21256723
20maturation of 5.8S rRNA (GO:0000460)3.19792868
21anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.17145499
22maturation of SSU-rRNA (GO:0030490)3.16615656
23RNA capping (GO:0036260)3.15664730
247-methylguanosine RNA capping (GO:0009452)3.15664730
25somatic hypermutation of immunoglobulin genes (GO:0016446)3.15627098
26somatic diversification of immune receptors via somatic mutation (GO:0002566)3.15627098
27regulation of helicase activity (GO:0051095)3.14545922
28termination of RNA polymerase III transcription (GO:0006386)3.14334868
29transcription elongation from RNA polymerase III promoter (GO:0006385)3.14334868
30cotranslational protein targeting to membrane (GO:0006613)3.14327766
31presynaptic membrane assembly (GO:0097105)3.14083709
32positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.13853889
33DNA replication-independent nucleosome organization (GO:0034724)3.13684993
34DNA replication-independent nucleosome assembly (GO:0006336)3.13684993
35spliceosomal snRNP assembly (GO:0000387)3.12747696
36SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.12684345
37viral transcription (GO:0019083)3.12449416
38negative regulation of DNA recombination (GO:0045910)3.12185207
39regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.11462932
40viral mRNA export from host cell nucleus (GO:0046784)3.11221548
41translational termination (GO:0006415)3.09829586
42respiratory electron transport chain (GO:0022904)3.07157840
43nucleobase catabolic process (GO:0046113)3.06856188
44protein targeting to ER (GO:0045047)3.05623620
45rRNA modification (GO:0000154)3.02626861
46neural tube formation (GO:0001841)3.00817354
47electron transport chain (GO:0022900)3.00771825
48negative regulation of ligase activity (GO:0051352)2.96237594
49negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.96237594
50protein-cofactor linkage (GO:0018065)2.95070460
51DNA double-strand break processing (GO:0000729)2.94883242
52protein complex biogenesis (GO:0070271)2.94433791
53NADH dehydrogenase complex assembly (GO:0010257)2.94343798
54mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.94343798
55mitochondrial respiratory chain complex I assembly (GO:0032981)2.94343798
56negative regulation of DNA-dependent DNA replication (GO:2000104)2.93311293
57histone H2A acetylation (GO:0043968)2.93046106
58positive regulation of mitochondrial fission (GO:0090141)2.92560864
59deoxyribose phosphate biosynthetic process (GO:0046385)2.92345206
602-deoxyribonucleotide biosynthetic process (GO:0009265)2.92345206
61deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.91983384
62establishment of protein localization to endoplasmic reticulum (GO:0072599)2.90517024
63protein localization to endoplasmic reticulum (GO:0070972)2.90389408
64establishment of protein localization to mitochondrial membrane (GO:0090151)2.90017393
65water-soluble vitamin biosynthetic process (GO:0042364)2.90002254
66limb bud formation (GO:0060174)2.89447588
67histone exchange (GO:0043486)2.88218314
68positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.85822178
69mitotic metaphase plate congression (GO:0007080)2.83261551
70ribosomal small subunit assembly (GO:0000028)2.82562618
71protein K11-linked ubiquitination (GO:0070979)2.81280980
72DNA ligation (GO:0006266)2.81216682
73kinetochore assembly (GO:0051382)2.79956589
74kinetochore organization (GO:0051383)2.79230542
75translational initiation (GO:0006413)2.78184629
76intraciliary transport (GO:0042073)2.76837149
77nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.75465728
78regulation of cellular amino acid metabolic process (GO:0006521)2.75189124
79mitochondrial respiratory chain complex assembly (GO:0033108)2.74829905
80respiratory chain complex IV assembly (GO:0008535)2.74702255
81deoxyribonucleotide biosynthetic process (GO:0009263)2.74562021
82resolution of meiotic recombination intermediates (GO:0000712)2.73386128
83organelle disassembly (GO:1903008)2.72850659
84exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.72646574
85establishment of viral latency (GO:0019043)2.71340883
86neuron cell-cell adhesion (GO:0007158)2.70889827
87translation (GO:0006412)2.70681492
88rRNA methylation (GO:0031167)2.69465558
89positive regulation of ligase activity (GO:0051351)2.69043349
90presynaptic membrane organization (GO:0097090)2.69014904
91translational elongation (GO:0006414)2.68550866
92GTP biosynthetic process (GO:0006183)2.68518893
93cellular protein complex disassembly (GO:0043624)2.65786495
94peptidyl-histidine modification (GO:0018202)2.65387308
95regulation of mitochondrial translation (GO:0070129)2.64358225
96nonmotile primary cilium assembly (GO:0035058)2.63745220
97protein localization to cilium (GO:0061512)2.63624196
98pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.63023496
99DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.61889048
100non-recombinational repair (GO:0000726)2.61340774
101double-strand break repair via nonhomologous end joining (GO:0006303)2.61340774
102positive regulation of synapse assembly (GO:0051965)2.59827167
103DNA catabolic process, exonucleolytic (GO:0000738)2.59462871
104guanosine-containing compound biosynthetic process (GO:1901070)2.57553373
105DNA replication checkpoint (GO:0000076)2.57171167
106replication fork processing (GO:0031297)2.56377156
107histone arginine methylation (GO:0034969)2.56359019
108signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.55589471
109intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.55589471
110negative regulation of telomere maintenance (GO:0032205)2.55244887
111DNA damage response, detection of DNA damage (GO:0042769)2.55008902
112regulation of ubiquitin-protein transferase activity (GO:0051438)2.54731499
113nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.54701078
114regulation of development, heterochronic (GO:0040034)2.54586260
115signal transduction involved in cell cycle checkpoint (GO:0072395)2.54046387
116signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.53364315
117signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.53364315
118signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.53364315
119peptidyl-arginine omega-N-methylation (GO:0035247)2.53152050
120peptidyl-arginine N-methylation (GO:0035246)2.53005612
121peptidyl-arginine methylation (GO:0018216)2.53005612
122transcription elongation from RNA polymerase II promoter (GO:0006368)2.52862729
123protein targeting to mitochondrion (GO:0006626)2.51656364
124signal transduction involved in DNA integrity checkpoint (GO:0072401)2.51167086
125signal transduction involved in DNA damage checkpoint (GO:0072422)2.51167086
126postsynaptic membrane organization (GO:0001941)2.50865459
127sequestering of actin monomers (GO:0042989)2.50707441
128regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.50434179
129transcription-coupled nucleotide-excision repair (GO:0006283)2.50371952
130DNA replication-dependent nucleosome assembly (GO:0006335)2.50042879
131DNA replication-dependent nucleosome organization (GO:0034723)2.50042879
132ribosomal large subunit biogenesis (GO:0042273)2.49782279
133attachment of spindle microtubules to kinetochore (GO:0008608)2.49095547
134metaphase plate congression (GO:0051310)2.47707782
135centriole replication (GO:0007099)2.45572963
136protein K6-linked ubiquitination (GO:0085020)2.45076981
137somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.43714914
138somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.43714914
139isotype switching (GO:0045190)2.43714914
140telomere maintenance via telomerase (GO:0007004)2.39373951
141ribonucleoprotein complex disassembly (GO:0032988)2.39330015
142negative regulation of transcription regulatory region DNA binding (GO:2000678)2.38509852
143L-serine metabolic process (GO:0006563)2.35670222
144somite development (GO:0061053)2.34932424
145mitotic spindle checkpoint (GO:0071174)2.34832356
146RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.34326876
147tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.34326876
148histone mRNA metabolic process (GO:0008334)2.33797202
149mannosylation (GO:0097502)2.33646760
150spindle checkpoint (GO:0031577)2.33532687
151regulation of centriole replication (GO:0046599)2.32667173
152regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.32480265
153mismatch repair (GO:0006298)2.30598633
154postreplication repair (GO:0006301)2.30490487
155DNA integration (GO:0015074)2.29877341
156cilium morphogenesis (GO:0060271)2.29596963
157microtubule depolymerization (GO:0007019)2.28875092
158gamma-aminobutyric acid transport (GO:0015812)2.26665315
159olfactory bulb development (GO:0021772)2.25946027
160cytochrome complex assembly (GO:0017004)2.25639422
161GPI anchor metabolic process (GO:0006505)2.25149667

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.82181467
2* MYC_18555785_ChIP-Seq_MESCs_Mouse3.36224224
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.35528809
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.35311007
5RBPJ_22232070_ChIP-Seq_NCS_Mouse3.12818996
6HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.97312991
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.72131520
8CREB1_15753290_ChIP-ChIP_HEK293T_Human2.67794093
9IGF1R_20145208_ChIP-Seq_DFB_Human2.67312168
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.65672798
11E2F7_22180533_ChIP-Seq_HELA_Human2.59263872
12* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.52997201
13* MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.50441851
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.48073259
15EZH2_22144423_ChIP-Seq_EOC_Human2.46207896
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.39486582
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.36760006
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.36114577
19SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.35608114
20E2F4_17652178_ChIP-ChIP_JURKAT_Human2.26319149
21* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.12094263
22NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.07121568
23FUS_26573619_Chip-Seq_HEK293_Human2.03909625
24* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.03449715
25MYC_18358816_ChIP-ChIP_MESCs_Mouse2.02784349
26ELK1_19687146_ChIP-ChIP_HELA_Human2.02093079
27FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.97647095
28* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.96481585
29PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.95070736
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.91392375
31EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.89257544
32DCP1A_22483619_ChIP-Seq_HELA_Human1.88989660
33VDR_23849224_ChIP-Seq_CD4+_Human1.84869377
34TAF15_26573619_Chip-Seq_HEK293_Human1.81830958
35TTF2_22483619_ChIP-Seq_HELA_Human1.80879871
36XRN2_22483619_ChIP-Seq_HELA_Human1.80135818
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.80072799
38* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.76788234
39* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.74248333
40YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.72838465
41CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.71852139
42VDR_22108803_ChIP-Seq_LS180_Human1.70322484
43POU5F1_16153702_ChIP-ChIP_HESCs_Human1.56490606
44GBX2_23144817_ChIP-Seq_PC3_Human1.56281132
45ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.56197103
46TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.55538897
47GABP_19822575_ChIP-Seq_HepG2_Human1.55146348
48FOXM1_23109430_ChIP-Seq_U2OS_Human1.54320177
49* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.48762378
50CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.48172318
51EWS_26573619_Chip-Seq_HEK293_Human1.47600593
52ZNF274_21170338_ChIP-Seq_K562_Hela1.46665922
53FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.45933184
54FOXP3_21729870_ChIP-Seq_TREG_Human1.45239276
55POU3F2_20337985_ChIP-ChIP_501MEL_Human1.44674737
56CTBP2_25329375_ChIP-Seq_LNCAP_Human1.42089160
57MYCN_18555785_ChIP-Seq_MESCs_Mouse1.41674672
58SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38898020
59BMI1_23680149_ChIP-Seq_NPCS_Mouse1.38708654
60PADI4_21655091_ChIP-ChIP_MCF-7_Human1.37073618
61POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.36324963
62PCGF2_27294783_Chip-Seq_ESCs_Mouse1.35801734
63SRF_21415370_ChIP-Seq_HL-1_Mouse1.35470098
64* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.35370456
65CBX2_27304074_Chip-Seq_ESCs_Mouse1.35290151
66MYC_18940864_ChIP-ChIP_HL60_Human1.34529467
67MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.33283255
68GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33130320
69ZFX_18555785_ChIP-Seq_MESCs_Mouse1.29643567
70YY1_21170310_ChIP-Seq_MESCs_Mouse1.29272602
71ELF1_17652178_ChIP-ChIP_JURKAT_Human1.28970237
72UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.27544720
73CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.26000232
74IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.24542738
75CBP_20019798_ChIP-Seq_JUKART_Human1.24542738
76RNF2_27304074_Chip-Seq_NSC_Mouse1.23390494
77* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.22533356
78ELK1_22589737_ChIP-Seq_MCF10A_Human1.22291727
79ZFP57_27257070_Chip-Seq_ESCs_Mouse1.22251080
80AR_21909140_ChIP-Seq_LNCAP_Human1.21413198
81OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20621188
82AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20036457
83SALL1_21062744_ChIP-ChIP_HESCs_Human1.19248570
84TP63_19390658_ChIP-ChIP_HaCaT_Human1.19206953
85ER_23166858_ChIP-Seq_MCF-7_Human1.15987814
86SOX2_18555785_ChIP-Seq_MESCs_Mouse1.15338321
87CTBP1_25329375_ChIP-Seq_LNCAP_Human1.14021281
88GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.13362793
89* SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.13218826
90PIAS1_25552417_ChIP-Seq_VCAP_Human1.12535203
91SMAD4_21799915_ChIP-Seq_A2780_Human1.11838692
92KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.10218660
93SMAD3_21741376_ChIP-Seq_EPCs_Human1.09676334
94GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08575393
95POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.08492491
96TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08465028
97REST_19997604_ChIP-ChIP_NEURONS_Mouse1.08318979
98EZH2_27304074_Chip-Seq_ESCs_Mouse1.07020032
99FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.06637765
100SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05606578
101EZH2_27294783_Chip-Seq_NPCs_Mouse1.05576525
102SOX2_16153702_ChIP-ChIP_HESCs_Human1.04390413
103NANOG_18555785_Chip-Seq_ESCs_Mouse1.03737293
104KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03557442
105PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.03393507
106TP53_22573176_ChIP-Seq_HFKS_Human1.03383872
107SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.02881424
108TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02493116
109* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.02125940
110ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.01768173
111AR_25329375_ChIP-Seq_VCAP_Human1.01748603
112SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.01150637
113E2F1_21310950_ChIP-Seq_MCF-7_Human0.98571620
114EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97804992
115RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.97431081
116HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.95696245
117* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.95602156
118PCGF2_27294783_Chip-Seq_NPCs_Mouse0.95250856
119NANOG_19829295_ChIP-Seq_ESCs_Human0.94806166
120SOX2_19829295_ChIP-Seq_ESCs_Human0.94806166
121NFE2_27457419_Chip-Seq_LIVER_Mouse0.94188061
122EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.93065352
123PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.92905953
124* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92718635
125NANOG_16153702_ChIP-ChIP_HESCs_Human0.91667702
126CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.90364070
127FLI1_27457419_Chip-Seq_LIVER_Mouse0.89987720
128DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.89925899
129SOX9_26525672_Chip-Seq_HEART_Mouse0.88776110
130PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.86918966
131CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.86362465
132P300_19829295_ChIP-Seq_ESCs_Human0.85750936
133NANOG_18555785_ChIP-Seq_MESCs_Mouse0.85595823
134TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.84091095
135CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.83332821
136* SOX17_20123909_ChIP-Seq_XEN_Mouse0.82094019
137IRF1_19129219_ChIP-ChIP_H3396_Human0.79226914

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.29499867
2MP0006292_abnormal_olfactory_placode2.60903603
3MP0003693_abnormal_embryo_hatching2.57576051
4MP0003123_paternal_imprinting2.48963442
5MP0004957_abnormal_blastocyst_morpholog2.40307326
6MP0002638_abnormal_pupillary_reflex2.27077954
7MP0009379_abnormal_foot_pigmentation2.21005637
8MP0008877_abnormal_DNA_methylation2.18793585
9MP0003121_genomic_imprinting2.07411926
10MP0003122_maternal_imprinting2.05850079
11MP0001529_abnormal_vocalization2.02120377
12MP0006276_abnormal_autonomic_nervous1.99303507
13MP0008932_abnormal_embryonic_tissue1.96387197
14MP0003315_abnormal_perineum_morphology1.86875133
15MP0003787_abnormal_imprinting1.81407240
16MP0003718_maternal_effect1.75599789
17MP0002938_white_spotting1.72822210
18MP0004270_analgesia1.71009714
19MP0001293_anophthalmia1.68223356
20MP0002234_abnormal_pharynx_morphology1.67710377
21MP0010030_abnormal_orbit_morphology1.66878394
22MP0002653_abnormal_ependyma_morphology1.64442981
23MP0000049_abnormal_middle_ear1.63715421
24MP0000778_abnormal_nervous_system1.61790450
25MP0000631_abnormal_neuroendocrine_gland1.61553070
26MP0003567_abnormal_fetal_cardiomyocyte1.58251935
27MP0010094_abnormal_chromosome_stability1.57009332
28MP0004133_heterotaxia1.56695923
29MP0002734_abnormal_mechanical_nocicepti1.54635297
30MP0002282_abnormal_trachea_morphology1.52328766
31MP0005253_abnormal_eye_physiology1.51244238
32MP0003937_abnormal_limbs/digits/tail_de1.51130219
33MP0006072_abnormal_retinal_apoptosis1.50602236
34MP0008789_abnormal_olfactory_epithelium1.50593673
35MP0003077_abnormal_cell_cycle1.46790734
36MP0009697_abnormal_copulation1.45178557
37MP0005646_abnormal_pituitary_gland1.45140705
38MP0010386_abnormal_urinary_bladder1.43405595
39MP0009046_muscle_twitch1.42165047
40MP0001968_abnormal_touch/_nociception1.41900688
41MP0008058_abnormal_DNA_repair1.40967123
42MP0002102_abnormal_ear_morphology1.40879701
43MP0003938_abnormal_ear_development1.40451990
44MP0002184_abnormal_innervation1.39168688
45MP0009250_abnormal_appendicular_skeleto1.35456098
46MP0000537_abnormal_urethra_morphology1.34547212
47MP0005551_abnormal_eye_electrophysiolog1.33521590
48MP0002837_dystrophic_cardiac_calcinosis1.33035095
49MP0008995_early_reproductive_senescence1.32903014
50MP0003119_abnormal_digestive_system1.31275636
51MP0002736_abnormal_nociception_after1.30893418
52MP0003890_abnormal_embryonic-extraembry1.29760821
53MP0004147_increased_porphyrin_level1.28431413
54MP0005084_abnormal_gallbladder_morpholo1.27519013
55MP0008057_abnormal_DNA_replication1.26977819
56MP0003635_abnormal_synaptic_transmissio1.26773913
57MP0001188_hyperpigmentation1.25216347
58MP0003111_abnormal_nucleus_morphology1.24332652
59MP0005187_abnormal_penis_morphology1.21718247
60MP0001905_abnormal_dopamine_level1.21484324
61MP0002163_abnormal_gland_morphology1.20304144
62MP0001286_abnormal_eye_development1.20272300
63MP0002063_abnormal_learning/memory/cond1.19694303
64MP0005499_abnormal_olfactory_system1.19596604
65MP0005394_taste/olfaction_phenotype1.19596604
66MP0000647_abnormal_sebaceous_gland1.18841235
67MP0002822_catalepsy1.17481932
68MP0002751_abnormal_autonomic_nervous1.17406361
69MP0003942_abnormal_urinary_system1.17165327
70MP0005645_abnormal_hypothalamus_physiol1.16825441
71MP0002249_abnormal_larynx_morphology1.15828430
72MP0008007_abnormal_cellular_replicative1.15443154
73MP0002572_abnormal_emotion/affect_behav1.10729121
74MP0003755_abnormal_palate_morphology1.07663622
75MP0000566_synostosis1.06037396
76MP0002090_abnormal_vision1.05451908
77MP0003861_abnormal_nervous_system1.04620407
78MP0005379_endocrine/exocrine_gland_phen1.02884980
79MP0002067_abnormal_sensory_capabilities1.02548193
80MP0001984_abnormal_olfaction1.02437114
81MP0005408_hypopigmentation1.02352518
82MP0002233_abnormal_nose_morphology1.01966923
83MP0002272_abnormal_nervous_system1.01454657
84MP0004859_abnormal_synaptic_plasticity1.01434498
85MP0004142_abnormal_muscle_tone1.01091159
86MP0002557_abnormal_social/conspecific_i1.01071132
87MP0003385_abnormal_body_wall1.00644923
88MP0005391_vision/eye_phenotype1.00249396
89MP0002210_abnormal_sex_determination0.99549748
90MP0005423_abnormal_somatic_nervous0.99175334
91MP0005503_abnormal_tendon_morphology0.99049988
92MP0002697_abnormal_eye_size0.98939092
93MP0009745_abnormal_behavioral_response0.98480151
94MP0003786_premature_aging0.97532696
95MP0002752_abnormal_somatic_nervous0.97157031
96MP0002177_abnormal_outer_ear0.95994780
97MP0004811_abnormal_neuron_physiology0.95189236
98MP0003646_muscle_fatigue0.93848677
99MP0003011_delayed_dark_adaptation0.93289487
100MP0005248_abnormal_Harderian_gland0.93184320
101MP0002735_abnormal_chemical_nociception0.91743223
102MP0001485_abnormal_pinna_reflex0.90952687
103MP0005367_renal/urinary_system_phenotyp0.90189091
104MP0000516_abnormal_urinary_system0.90189091
105MP0000026_abnormal_inner_ear0.89498076
106MP0002160_abnormal_reproductive_system0.89370909
107MP0001486_abnormal_startle_reflex0.88856195
108MP0003136_yellow_coat_color0.88515171
109MP0001177_atelectasis0.88446766
110MP0006035_abnormal_mitochondrial_morpho0.87272299
111MP0000653_abnormal_sex_gland0.86178788
112MP0000372_irregular_coat_pigmentation0.85310754
113MP0003195_calcinosis0.85249609
114MP0002116_abnormal_craniofacial_bone0.85225245
115MP0002085_abnormal_embryonic_tissue0.85107432
116MP0004233_abnormal_muscle_weight0.84696142
117MP0005195_abnormal_posterior_eye0.84585687
118MP0002114_abnormal_axial_skeleton0.84133935
119MP0002152_abnormal_brain_morphology0.83744595
120MP0003221_abnormal_cardiomyocyte_apopto0.83653774
121MP0001929_abnormal_gametogenesis0.83624655
122MP0002882_abnormal_neuron_morphology0.83362967
123MP0000678_abnormal_parathyroid_gland0.82563835
124MP0000955_abnormal_spinal_cord0.81928477
125MP0001970_abnormal_pain_threshold0.81723578
126MP0001145_abnormal_male_reproductive0.81720932
127MP0001697_abnormal_embryo_size0.81165709
128MP0006036_abnormal_mitochondrial_physio0.81122961
129MP0004215_abnormal_myocardial_fiber0.81002523
130MP0005386_behavior/neurological_phenoty0.80229774
131MP0004924_abnormal_behavior0.80229774

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)3.94030555
2Abnormal mitochondria in muscle tissue (HP:0008316)3.57683181
3Mitochondrial inheritance (HP:0001427)3.35705762
4Increased hepatocellular lipid droplets (HP:0006565)3.32936544
5Progressive macrocephaly (HP:0004481)3.28190888
6Increased CSF lactate (HP:0002490)3.07340734
7Acute encephalopathy (HP:0006846)2.97445484
8Decreased activity of mitochondrial respiratory chain (HP:0008972)2.91594195
9Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.91594195
10Abnormality of the labia minora (HP:0012880)2.89609439
11Abnormality of glycolysis (HP:0004366)2.81360127
12Increased serum pyruvate (HP:0003542)2.81360127
13Hepatocellular necrosis (HP:0001404)2.79509170
14Lipid accumulation in hepatocytes (HP:0006561)2.76677989
15Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.63541801
16Birth length less than 3rd percentile (HP:0003561)2.60277824
17Renal Fanconi syndrome (HP:0001994)2.55046594
18Methylmalonic acidemia (HP:0002912)2.53498598
19Patellar aplasia (HP:0006443)2.53270205
20Aplasia/Hypoplasia of the patella (HP:0006498)2.46060847
21Cortical dysplasia (HP:0002539)2.45360044
22Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.45106978
23Abnormality of alanine metabolism (HP:0010916)2.45106978
24Hyperalaninemia (HP:0003348)2.45106978
25Fibular aplasia (HP:0002990)2.42013960
26Nephronophthisis (HP:0000090)2.41762845
27Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.41499319
28Hepatic necrosis (HP:0002605)2.34614360
29Breast hypoplasia (HP:0003187)2.33571549
30Abnormal pancreas size (HP:0012094)2.33081265
31Hyperglycinemia (HP:0002154)2.29758030
32Aplasia/hypoplasia of the uterus (HP:0008684)2.29701453
33Medulloblastoma (HP:0002885)2.28426990
34Adrenal hypoplasia (HP:0000835)2.28313968
35Lissencephaly (HP:0001339)2.24971037
36Colon cancer (HP:0003003)2.19438571
37Hyperinsulinemic hypoglycemia (HP:0000825)2.18422547
38Supernumerary spleens (HP:0009799)2.17621090
39Aplastic anemia (HP:0001915)2.12730327
40Nephroblastoma (Wilms tumor) (HP:0002667)2.12378312
41Medial flaring of the eyebrow (HP:0010747)2.09882882
42Abnormality of chromosome stability (HP:0003220)2.09504087
43Meckel diverticulum (HP:0002245)2.09374416
44Aplasia/Hypoplasia of the sternum (HP:0006714)2.08603714
45Pancreatic fibrosis (HP:0100732)2.08565603
46True hermaphroditism (HP:0010459)2.07263246
47Embryonal renal neoplasm (HP:0011794)2.07154612
48Gait imbalance (HP:0002141)2.06926970
49Congenital primary aphakia (HP:0007707)2.06908181
50Drooling (HP:0002307)2.06775371
51Lactic acidosis (HP:0003128)2.06631084
52Ependymoma (HP:0002888)2.05814330
53Carpal bone hypoplasia (HP:0001498)2.05659883
54Rhabdomyosarcoma (HP:0002859)2.04959845
55Hepatoblastoma (HP:0002884)2.02280650
56Aplasia/Hypoplasia of the uvula (HP:0010293)2.02168529
57Abnormality of cells of the erythroid lineage (HP:0012130)2.01301913
58Abnormality of the ileum (HP:0001549)2.00696373
59Limb dystonia (HP:0002451)1.99568487
60Focal motor seizures (HP:0011153)1.99460661
61Increased serum lactate (HP:0002151)1.98336746
62Exercise intolerance (HP:0003546)1.97549991
63Increased intramyocellular lipid droplets (HP:0012240)1.97547786
64Reticulocytopenia (HP:0001896)1.97116951
653-Methylglutaconic aciduria (HP:0003535)1.96854823
66Pancreatic cysts (HP:0001737)1.96050099
67Volvulus (HP:0002580)1.95739059
68Specific learning disability (HP:0001328)1.95547243
69Hypothermia (HP:0002045)1.94989723
70Intestinal atresia (HP:0011100)1.94792495
71Polyphagia (HP:0002591)1.93086173
72Diastasis recti (HP:0001540)1.92506767
73Progressive inability to walk (HP:0002505)1.92361375
74Abnormality of the renal medulla (HP:0100957)1.91928657
75Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.90959954
76Optic disc pallor (HP:0000543)1.90097923
77Respiratory difficulties (HP:0002880)1.89873870
78Nephrogenic diabetes insipidus (HP:0009806)1.89826110
79Postaxial hand polydactyly (HP:0001162)1.88993237
80Glioma (HP:0009733)1.88733507
81Optic nerve hypoplasia (HP:0000609)1.87410835
82Congenital, generalized hypertrichosis (HP:0004540)1.86455845
83Abnormality of the metopic suture (HP:0005556)1.86065334
84Short tibia (HP:0005736)1.85645889
85Aplasia/Hypoplasia of the tibia (HP:0005772)1.84927798
86Atonic seizures (HP:0010819)1.83285440
87Broad-based gait (HP:0002136)1.82630038
88Horseshoe kidney (HP:0000085)1.82585095
89Shoulder girdle muscle weakness (HP:0003547)1.82269733
90Abnormality of the astrocytes (HP:0100707)1.81917558
91Astrocytoma (HP:0009592)1.81917558
92Aplasia/Hypoplasia of the tongue (HP:0010295)1.81333725
93Stenosis of the external auditory canal (HP:0000402)1.79870111
94Methylmalonic aciduria (HP:0012120)1.79820899
95Decreased testicular size (HP:0008734)1.79697615
96Exertional dyspnea (HP:0002875)1.79154133
97Anencephaly (HP:0002323)1.78708289
98Retinal dysplasia (HP:0007973)1.78433693
99Excessive salivation (HP:0003781)1.77821177
100Cerebral hypomyelination (HP:0006808)1.77571000
101Respiratory failure (HP:0002878)1.77201689
102Sloping forehead (HP:0000340)1.76673925
103Septo-optic dysplasia (HP:0100842)1.76453000
104Dandy-Walker malformation (HP:0001305)1.76138196
105Broad foot (HP:0001769)1.74833401
106Abnormal lung lobation (HP:0002101)1.74743080
107Inability to walk (HP:0002540)1.74408269
108Pachygyria (HP:0001302)1.74104992
109Postaxial foot polydactyly (HP:0001830)1.73933952
110Abnormality of serum amino acid levels (HP:0003112)1.73799951
111Preaxial hand polydactyly (HP:0001177)1.73360556
112Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.73177385
113Abnormal number of erythroid precursors (HP:0012131)1.72853838
114Sclerocornea (HP:0000647)1.72032353
115Macrocytic anemia (HP:0001972)1.71637333
116Abolished electroretinogram (ERG) (HP:0000550)1.70989016
117Molar tooth sign on MRI (HP:0002419)1.70192749
118Abnormality of midbrain morphology (HP:0002418)1.70192749
119Poor suck (HP:0002033)1.70120091
120Gastrointestinal atresia (HP:0002589)1.69523419
121Hypsarrhythmia (HP:0002521)1.68898648
122Type II lissencephaly (HP:0007260)1.68436985
123Aplasia involving forearm bones (HP:0009822)1.68264537
124Absent forearm bone (HP:0003953)1.68264537
125Oligodactyly (HP:0012165)1.67162188
126Anophthalmia (HP:0000528)1.66295935
127Muscular hypotonia of the trunk (HP:0008936)1.66266215
128Scrotal hypoplasia (HP:0000046)1.66219149
129Abnormality of the hip-girdle musculature (HP:0001445)1.65759409
130Abnormality of the musculature of the pelvis (HP:0001469)1.65759409
131Hyperventilation (HP:0002883)1.65439980
132Abnormality of serine family amino acid metabolism (HP:0010894)1.65307740
133Abnormality of glycine metabolism (HP:0010895)1.65307740
134Short 1st metacarpal (HP:0010034)1.65235450
135Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.65235450
136Triphalangeal thumb (HP:0001199)1.65231231
137Oral leukoplakia (HP:0002745)1.65127541
138Narrow forehead (HP:0000341)1.64984282
139Split foot (HP:0001839)1.64367206
140Genital tract atresia (HP:0001827)1.64071870
141Poor coordination (HP:0002370)1.63507433
142Atrophy/Degeneration involving motor neurons (HP:0007373)1.63492496
143Abnormality of the duodenum (HP:0002246)1.63434155
144Renal cortical cysts (HP:0000803)1.63191079
145Leukodystrophy (HP:0002415)1.62572656
146Neoplasm of the adrenal gland (HP:0100631)1.62225255
147Febrile seizures (HP:0002373)1.61035189
148Absent radius (HP:0003974)1.60550457
149Pallor (HP:0000980)1.60543497
150Vaginal atresia (HP:0000148)1.59883826
151High anterior hairline (HP:0009890)1.59708979
152Shawl scrotum (HP:0000049)1.58641729
153Cerebral edema (HP:0002181)1.58279518
154Rimmed vacuoles (HP:0003805)1.58207982
155Abnormality of the anterior horn cell (HP:0006802)1.57984445
156Degeneration of anterior horn cells (HP:0002398)1.57984445
157Myokymia (HP:0002411)1.57379215
158Oligodactyly (hands) (HP:0001180)1.56180175
159Aplasia/Hypoplasia of the fibula (HP:0006492)1.55198464
160Depressed nasal ridge (HP:0000457)1.55197943
161Sparse lateral eyebrow (HP:0005338)1.54250395

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM283.40629259
2SRPK13.37666733
3EIF2AK13.04227047
4CASK2.91194813
5STK162.84631209
6BUB12.79107221
7WEE12.38878811
8CCNB12.35555032
9MAP4K22.18227400
10DYRK22.16010014
11MAP2K72.13840616
12MAP3K122.13410440
13MKNK12.09962676
14CDC72.02474077
15MARK11.99639882
16NTRK31.93345849
17NME11.93100255
18EIF2AK31.87432474
19MAPK131.76551162
20STK38L1.72292350
21MKNK21.71746617
22CDK191.70289410
23MAP3K41.68636446
24VRK11.67827449
25BRSK21.67441798
26PLK41.66272734
27PLK31.61895794
28PLK21.60843767
29VRK21.58005687
30LIMK11.56214835
31DYRK31.54523569
32NUAK11.50469744
33ZAK1.46784579
34CSNK1A1L1.45453994
35TAF11.34496200
36CDK81.33962755
37GRK11.23019030
38NEK11.20492415
39STK241.20141673
40BCR1.16644685
41MST41.16459745
42BRAF1.14509358
43WNK31.13929853
44TLK11.13677032
45PASK1.12409575
46RPS6KA41.12347063
47ERBB31.12112309
48PNCK1.11447242
49UHMK11.11393724
50BRSK11.08506906
51PLK11.07609086
52EPHA41.06350733
53MUSK1.02157830
54DYRK1A1.01210455
55AKT30.99090366
56PBK0.97984083
57AURKA0.97437713
58TSSK60.97168945
59BMPR20.94787737
60LATS20.93521896
61ILK0.90696004
62TTK0.90626859
63MINK10.90214002
64BMPR1B0.90161643
65CAMK2B0.86616187
66CDK30.85776522
67BCKDK0.85487047
68KSR10.83569726
69PAK30.82867101
70PRKCE0.81866675
71AURKB0.80250537
72PINK10.80045395
73DAPK10.79099674
74ADRBK20.78624676
75PDK40.77499342
76PDK30.77499342
77YES10.73359231
78FGFR20.70508172
79ACVR1B0.69366960
80CHEK20.68671409
81ERBB40.68397779
82NLK0.68023986
83CDK140.65607352
84CSNK1G30.63932938
85TESK10.62938506
86EIF2AK20.61577718
87FER0.58910279
88CAMK2A0.57816123
89CDK90.57255512
90ADRBK10.57108406
91MAP2K40.55450997
92CAMKK20.55323891
93PRKCG0.55073383
94CDK180.54905173
95CSNK2A10.54602620
96MAP3K90.53807089
97ARAF0.52295658
98NME20.50166546
99OXSR10.50000949
100INSRR0.49908294
101SIK30.49358212
102STK390.49319070
103MYLK0.48850696
104CSNK2A20.48237051
105CDK150.48001901
106ATR0.45880487
107EPHA30.45044163
108CDK11A0.45022274
109CSNK1G20.44272378
110MAP3K60.43811225
111TESK20.43675109
112TGFBR10.41897068
113FRK0.41372121
114CSNK1G10.41115231
115ATM0.40709509
116CSNK1E0.40652780
117TNIK0.40254266
118NTRK20.38940944
119WNK40.38635099
120CSNK1A10.38543382
121GRK50.38445883
122CDK10.37860336
123CAMK2D0.37230846
124CDK70.37213415
125SGK20.36894578
126CSNK1D0.36369114
127PRKCI0.35359490
128SGK2230.33856325
129SGK4940.33856325
130FGFR10.33740364
131NEK20.32802908
132RPS6KA50.31519509
133PRKACB0.30869457

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.93089463
2Ribosome_Homo sapiens_hsa030103.69413357
3Oxidative phosphorylation_Homo sapiens_hsa001903.54714924
4Protein export_Homo sapiens_hsa030603.37472970
5RNA polymerase_Homo sapiens_hsa030203.29229705
6Parkinsons disease_Homo sapiens_hsa050123.04238651
7Spliceosome_Homo sapiens_hsa030402.88584632
8DNA replication_Homo sapiens_hsa030302.62536076
9Huntingtons disease_Homo sapiens_hsa050162.59073673
10Mismatch repair_Homo sapiens_hsa034302.57473678
11RNA transport_Homo sapiens_hsa030132.35109883
12Alzheimers disease_Homo sapiens_hsa050102.23387546
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.21696531
14Basal transcription factors_Homo sapiens_hsa030222.13686682
15Pyrimidine metabolism_Homo sapiens_hsa002402.12932376
16Homologous recombination_Homo sapiens_hsa034402.01268703
17Nucleotide excision repair_Homo sapiens_hsa034201.99490567
18Cell cycle_Homo sapiens_hsa041101.98264230
19RNA degradation_Homo sapiens_hsa030181.91156660
20Steroid biosynthesis_Homo sapiens_hsa001001.90822387
21Propanoate metabolism_Homo sapiens_hsa006401.89869972
22Nicotine addiction_Homo sapiens_hsa050331.75497404
23Cardiac muscle contraction_Homo sapiens_hsa042601.54784906
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.52948462
25Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.51533765
26Butanoate metabolism_Homo sapiens_hsa006501.51060275
27Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.47086312
28Oocyte meiosis_Homo sapiens_hsa041141.45949271
29Vibrio cholerae infection_Homo sapiens_hsa051101.42223253
30Fatty acid elongation_Homo sapiens_hsa000621.41199820
31Base excision repair_Homo sapiens_hsa034101.40713213
32Purine metabolism_Homo sapiens_hsa002301.33548863
33mRNA surveillance pathway_Homo sapiens_hsa030151.33344811
34Collecting duct acid secretion_Homo sapiens_hsa049661.27042027
35Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.26785547
36Selenocompound metabolism_Homo sapiens_hsa004501.25383197
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.25135667
38Fanconi anemia pathway_Homo sapiens_hsa034601.23003804
39Maturity onset diabetes of the young_Homo sapiens_hsa049501.20091675
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.16416876
41Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.14041349
42Non-homologous end-joining_Homo sapiens_hsa034501.12257810
43Synaptic vesicle cycle_Homo sapiens_hsa047211.06782549
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.05784745
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.00399534
46Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.00063004
47Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.99827468
48Amphetamine addiction_Homo sapiens_hsa050310.97340880
49Peroxisome_Homo sapiens_hsa041460.94132157
50Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.93946720
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.93909654
52Dopaminergic synapse_Homo sapiens_hsa047280.92335294
53Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.90894020
54Vitamin B6 metabolism_Homo sapiens_hsa007500.87637551
55SNARE interactions in vesicular transport_Homo sapiens_hsa041300.83197211
56Long-term potentiation_Homo sapiens_hsa047200.82967513
57Taste transduction_Homo sapiens_hsa047420.82724937
58Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.80652613
59Serotonergic synapse_Homo sapiens_hsa047260.78201780
60beta-Alanine metabolism_Homo sapiens_hsa004100.73694204
61Alcoholism_Homo sapiens_hsa050340.67951848
62Hedgehog signaling pathway_Homo sapiens_hsa043400.65430598
632-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.65028363
64Epstein-Barr virus infection_Homo sapiens_hsa051690.63850633
65Wnt signaling pathway_Homo sapiens_hsa043100.62065164
66Fatty acid metabolism_Homo sapiens_hsa012120.61718575
67Phototransduction_Homo sapiens_hsa047440.61243840
68TGF-beta signaling pathway_Homo sapiens_hsa043500.61132512
69Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.60917235
70GABAergic synapse_Homo sapiens_hsa047270.60642806
71Pyruvate metabolism_Homo sapiens_hsa006200.59495219
72Circadian entrainment_Homo sapiens_hsa047130.57621643
73One carbon pool by folate_Homo sapiens_hsa006700.57599248
74Tryptophan metabolism_Homo sapiens_hsa003800.57110475
75Long-term depression_Homo sapiens_hsa047300.56965181
76Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.56247687
77Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.55999128
78Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.55624569
79Hippo signaling pathway_Homo sapiens_hsa043900.53917594
80Cysteine and methionine metabolism_Homo sapiens_hsa002700.53075078
81Circadian rhythm_Homo sapiens_hsa047100.52635656
82p53 signaling pathway_Homo sapiens_hsa041150.52345169
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52117391
84Glutamatergic synapse_Homo sapiens_hsa047240.51959243
85Nitrogen metabolism_Homo sapiens_hsa009100.51788332
86Morphine addiction_Homo sapiens_hsa050320.48228807
87Biosynthesis of amino acids_Homo sapiens_hsa012300.47233601
88Insulin secretion_Homo sapiens_hsa049110.47037258
89Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.46951782
90Axon guidance_Homo sapiens_hsa043600.46710514
91Primary bile acid biosynthesis_Homo sapiens_hsa001200.46684889
92Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.46572547
93Metabolic pathways_Homo sapiens_hsa011000.45923391
94Arginine and proline metabolism_Homo sapiens_hsa003300.44420550
95N-Glycan biosynthesis_Homo sapiens_hsa005100.44358281
96Cocaine addiction_Homo sapiens_hsa050300.43476507
97Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41827368
98Folate biosynthesis_Homo sapiens_hsa007900.41796542
99Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39955048
100Systemic lupus erythematosus_Homo sapiens_hsa053220.38855342
101Melanogenesis_Homo sapiens_hsa049160.37975458
102Sulfur metabolism_Homo sapiens_hsa009200.35947656
103Gap junction_Homo sapiens_hsa045400.34064848
104Ether lipid metabolism_Homo sapiens_hsa005650.33156323
105Cholinergic synapse_Homo sapiens_hsa047250.32871008
106Thyroid cancer_Homo sapiens_hsa052160.31899814
107Regulation of autophagy_Homo sapiens_hsa041400.31347806
108Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.30576469
109Tyrosine metabolism_Homo sapiens_hsa003500.29922655
110Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.28021530
111Colorectal cancer_Homo sapiens_hsa052100.25177701
112Oxytocin signaling pathway_Homo sapiens_hsa049210.24695617
113Renin secretion_Homo sapiens_hsa049240.23379267
114Calcium signaling pathway_Homo sapiens_hsa040200.22044013
115Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.21909062
116Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.21638957
117Basal cell carcinoma_Homo sapiens_hsa052170.21528924
118Olfactory transduction_Homo sapiens_hsa047400.19726230
119Glucagon signaling pathway_Homo sapiens_hsa049220.18954560
120Linoleic acid metabolism_Homo sapiens_hsa005910.18663014
121Melanoma_Homo sapiens_hsa052180.15906839
122Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.15713616
123Glutathione metabolism_Homo sapiens_hsa004800.15471787
124Carbon metabolism_Homo sapiens_hsa012000.15097526
125Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.13988669

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