BTD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene functions to recycle protein-bound biotin by cleaving biocytin (biotin-epsilon-lysine), a normal product of carboxylase degradation, resulting in regeneration of free biotin. The encoded protein has also been shown to have biotinyl transferase activity. Mutations in this gene are associated with biotinidase deficiency. Multiple transcript variants encoding different isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.99957385
2L-phenylalanine catabolic process (GO:0006559)6.99957385
3L-phenylalanine metabolic process (GO:0006558)6.75521839
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.75521839
5aromatic amino acid family catabolic process (GO:0009074)6.22405365
6epoxygenase P450 pathway (GO:0019373)5.90555413
7glyoxylate metabolic process (GO:0046487)5.74748833
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.74605829
9alpha-linolenic acid metabolic process (GO:0036109)5.56889453
10tryptophan catabolic process (GO:0006569)5.52402063
11indole-containing compound catabolic process (GO:0042436)5.52402063
12indolalkylamine catabolic process (GO:0046218)5.52402063
13bile acid biosynthetic process (GO:0006699)5.38172674
14kynurenine metabolic process (GO:0070189)5.34368025
15cysteine metabolic process (GO:0006534)5.34256095
16tryptophan metabolic process (GO:0006568)5.24599596
17sulfur amino acid catabolic process (GO:0000098)5.14869690
18exogenous drug catabolic process (GO:0042738)5.05271537
19peptidyl-glutamic acid carboxylation (GO:0017187)5.01600348
20protein carboxylation (GO:0018214)5.01600348
21high-density lipoprotein particle remodeling (GO:0034375)4.95213398
22negative regulation of fibrinolysis (GO:0051918)4.94888756
23lysine metabolic process (GO:0006553)4.84278320
24lysine catabolic process (GO:0006554)4.84278320
25fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.80682225
26serine family amino acid catabolic process (GO:0009071)4.75579385
27urea cycle (GO:0000050)4.74477035
28urea metabolic process (GO:0019627)4.74477035
29omega-hydroxylase P450 pathway (GO:0097267)4.69928180
30regulation of fibrinolysis (GO:0051917)4.66814405
31complement activation, alternative pathway (GO:0006957)4.63723416
32regulation of protein activation cascade (GO:2000257)4.62729456
33amino-acid betaine metabolic process (GO:0006577)4.58242182
34homocysteine metabolic process (GO:0050667)4.57038706
35bile acid metabolic process (GO:0008206)4.54782867
36glucuronate metabolic process (GO:0019585)4.54121049
37uronic acid metabolic process (GO:0006063)4.54121049
38aromatic amino acid family metabolic process (GO:0009072)4.52012362
39regulation of cholesterol esterification (GO:0010872)4.50227047
40phenylpropanoid metabolic process (GO:0009698)4.48001828
41reverse cholesterol transport (GO:0043691)4.47287920
42tyrosine metabolic process (GO:0006570)4.42988312
43regulation of triglyceride catabolic process (GO:0010896)4.41634392
44nitrogen cycle metabolic process (GO:0071941)4.36448213
45drug metabolic process (GO:0017144)4.34529533
46alpha-amino acid catabolic process (GO:1901606)4.34073425
47regulation of complement activation (GO:0030449)4.33862254
48plasma lipoprotein particle remodeling (GO:0034369)4.31924332
49protein-lipid complex remodeling (GO:0034368)4.31924332
50macromolecular complex remodeling (GO:0034367)4.31924332
51negative regulation of protein activation cascade (GO:2000258)4.18524713
52ethanol oxidation (GO:0006069)4.17588422
53serine family amino acid metabolic process (GO:0009069)4.14220097
54plasma lipoprotein particle clearance (GO:0034381)4.12857883
55serine family amino acid biosynthetic process (GO:0009070)4.12616413
56triglyceride homeostasis (GO:0070328)4.10519331
57acylglycerol homeostasis (GO:0055090)4.10519331
58cellular ketone body metabolic process (GO:0046950)4.10027523
59negative regulation of cholesterol transport (GO:0032375)4.09110957
60negative regulation of sterol transport (GO:0032372)4.09110957
61glycine metabolic process (GO:0006544)4.08035795
62cellular amino acid catabolic process (GO:0009063)4.06098960
63short-chain fatty acid metabolic process (GO:0046459)4.05602623
64coenzyme catabolic process (GO:0009109)4.04413605
65cellular modified amino acid catabolic process (GO:0042219)4.01474886
66negative regulation of complement activation (GO:0045916)3.98806755
67phospholipid efflux (GO:0033700)3.98668215
68NADH metabolic process (GO:0006734)3.97984667
69indolalkylamine metabolic process (GO:0006586)3.88296539
70glutamate metabolic process (GO:0006536)3.87434171
71daunorubicin metabolic process (GO:0044597)3.86511538
72polyketide metabolic process (GO:0030638)3.86511538
73doxorubicin metabolic process (GO:0044598)3.86511538
74drug transmembrane transport (GO:0006855)3.85887014
75cellular biogenic amine catabolic process (GO:0042402)3.85006062
76amine catabolic process (GO:0009310)3.85006062
77benzene-containing compound metabolic process (GO:0042537)3.83311515
78cellular glucuronidation (GO:0052695)3.82984296
79aldehyde catabolic process (GO:0046185)3.82681405
80blood coagulation, intrinsic pathway (GO:0007597)3.79133918
81low-density lipoprotein particle remodeling (GO:0034374)3.77334531
82acetyl-CoA metabolic process (GO:0006084)3.76938631
83fat-soluble vitamin biosynthetic process (GO:0042362)3.75213700
84plasma lipoprotein particle assembly (GO:0034377)3.75143077
85imidazole-containing compound metabolic process (GO:0052803)3.73003010
86drug catabolic process (GO:0042737)3.71875871
87cholesterol efflux (GO:0033344)3.70809285
88bile acid and bile salt transport (GO:0015721)3.70801655
89fatty acid beta-oxidation (GO:0006635)3.70408886
90urate metabolic process (GO:0046415)3.69007644
91arginine metabolic process (GO:0006525)3.69002719
92carboxylic acid catabolic process (GO:0046395)3.68136213
93organic acid catabolic process (GO:0016054)3.68136213
94carnitine metabolic process (GO:0009437)3.65176689
95fatty acid oxidation (GO:0019395)3.63893698
96aspartate family amino acid catabolic process (GO:0009068)3.63527994
97fibrinolysis (GO:0042730)3.60159701
98regulation of plasminogen activation (GO:0010755)3.60039277
99lipid oxidation (GO:0034440)3.58343062
100ketone body metabolic process (GO:1902224)3.58316260
101valine metabolic process (GO:0006573)3.57755079
102monocarboxylic acid catabolic process (GO:0072329)3.57623138
103very-low-density lipoprotein particle assembly (GO:0034379)3.56949661
1042-oxoglutarate metabolic process (GO:0006103)3.56346616
105cofactor catabolic process (GO:0051187)3.56222620
106fatty acid catabolic process (GO:0009062)3.52353880
107positive regulation of lipoprotein lipase activity (GO:0051006)3.49566872
108positive regulation of triglyceride lipase activity (GO:0061365)3.49566872
109L-ascorbic acid metabolic process (GO:0019852)3.48232892
110cholesterol homeostasis (GO:0042632)3.46680802
111heme transport (GO:0015886)3.46199682
112positive regulation of fatty acid beta-oxidation (GO:0032000)3.45992143
113positive regulation of lipid catabolic process (GO:0050996)3.44861459
114very long-chain fatty acid metabolic process (GO:0000038)3.44531965
115complement activation (GO:0006956)3.43608700
116negative regulation of lipase activity (GO:0060192)3.43395024
117complement activation, classical pathway (GO:0006958)3.43076383
118xenobiotic catabolic process (GO:0042178)3.41262676
119negative regulation of blood coagulation (GO:0030195)3.36981910
120negative regulation of hemostasis (GO:1900047)3.36981910
121aminoglycoside antibiotic metabolic process (GO:0030647)3.35486183
122negative regulation of coagulation (GO:0050819)3.34146033
123ethanol metabolic process (GO:0006067)3.33736490
124S-adenosylmethionine metabolic process (GO:0046500)3.32942438
125intestinal epithelial cell development (GO:0060576)3.20163874
126primary alcohol metabolic process (GO:0034308)3.19204531
127acute-phase response (GO:0006953)3.15837138
128transcytosis (GO:0045056)3.12484866
129intestinal cholesterol absorption (GO:0030299)3.09673161
130negative regulation of wound healing (GO:0061045)3.02336195
131oxaloacetate metabolic process (GO:0006107)3.02055458
132L-alpha-amino acid transmembrane transport (GO:1902475)3.00453506
133xenobiotic metabolic process (GO:0006805)2.99172494
134vitamin biosynthetic process (GO:0009110)2.97282959
135regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.95265899
136response to nitrosative stress (GO:0051409)2.95227579
137negative regulation of humoral immune response (GO:0002921)2.93152972
138hormone catabolic process (GO:0042447)2.91768765
139protein activation cascade (GO:0072376)2.88751455
140primary alcohol catabolic process (GO:0034310)2.86830262
141glycoside metabolic process (GO:0016137)2.85488891
142intestinal absorption (GO:0050892)2.85327492
143oxidative demethylation (GO:0070989)2.84569818
144phospholipid homeostasis (GO:0055091)2.82787707
145positive regulation of cellular amine metabolic process (GO:0033240)2.81915510
146retinal metabolic process (GO:0042574)2.81761488

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.79434789
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.74245325
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.15789353
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.01348184
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.81801132
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.74487603
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.69559194
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.78977768
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.56674192
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.98047386
11* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.90030668
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.80184849
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.55197264
14CLOCK_20551151_ChIP-Seq_293T_Human2.21445402
15* SRF_21415370_ChIP-Seq_HL-1_Mouse2.11509784
16HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.06926250
17ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.2106811
18EST1_17652178_ChIP-ChIP_JURKAT_Human1.91437873
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.91135299
20* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.90074092
21PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.76571500
22SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.72176150
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.64325976
24TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.64300056
25GATA1_22025678_ChIP-Seq_K562_Human1.60761678
26CREB1_15753290_ChIP-ChIP_HEK293T_Human1.60263629
27RARG_19884340_ChIP-ChIP_MEFs_Mouse1.56332806
28STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.56285744
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.52454403
30FOXA2_19822575_ChIP-Seq_HepG2_Human1.45216217
31NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.40524666
32STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.36871971
33THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.35587662
34HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.34867638
35IRF8_22096565_ChIP-ChIP_GC-B_Human1.30763471
36HNF4A_19822575_ChIP-Seq_HepG2_Human1.26484340
37PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.25262843
38* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.24163064
39IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.22956198
40EOMES_21245162_ChIP-Seq_HESCs_Human1.16746332
41CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.15304853
42KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.13344182
43KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.13344182
44KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.13344182
45ELK1_19687146_ChIP-ChIP_HELA_Human1.12083219
46TFEB_21752829_ChIP-Seq_HELA_Human1.10404327
47EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.05331359
48RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.05037570
49HTT_18923047_ChIP-ChIP_STHdh_Human1.03613066
50ETS1_20019798_ChIP-Seq_JURKAT_Human1.02933122
51* ELK1_22589737_ChIP-Seq_MCF10A_Human1.02687121
52SOX2_27498859_Chip-Seq_STOMACH_Mouse1.02576342
53RXRA_24833708_ChIP-Seq_LIVER_Mouse1.01564531
54ESR2_21235772_ChIP-Seq_MCF-7_Human1.01290538
55ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.99037470
56PADI4_21655091_ChIP-ChIP_MCF-7_Human0.98793861
57* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.98243418
58CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.96418305
59CBP_21632823_ChIP-Seq_H3396_Human0.95988328
60CDX2_22108803_ChIP-Seq_LS180_Human0.95534950
61* PIAS1_25552417_ChIP-Seq_VCAP_Human0.94982547
62FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94347665
63TRIM28_21343339_ChIP-Seq_HEK293_Human0.94322152
64* FOXA1_27270436_Chip-Seq_PROSTATE_Human0.94061166
65* FOXA1_25329375_ChIP-Seq_VCAP_Human0.94061166
66SOX17_20123909_ChIP-Seq_XEN_Mouse0.93307096
67ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.93154707
68CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.92579898
69GATA4_25053715_ChIP-Seq_YYC3_Human0.90532777
70DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.89552344
71* FOXA1_21572438_ChIP-Seq_LNCaP_Human0.89515390
72ESR1_21235772_ChIP-Seq_MCF-7_Human0.89223475
73EZH2_27294783_Chip-Seq_NPCs_Mouse0.86353916
74HOXB4_20404135_ChIP-ChIP_EML_Mouse0.86199680
75CDX2_19796622_ChIP-Seq_MESCs_Mouse0.85965345
76SALL4_18804426_ChIP-ChIP_XEN_Mouse0.85772118
77HNFA_21074721_ChIP-Seq_CACO-2_Human0.85442275
78* ERG_20517297_ChIP-Seq_VCAP_Human0.84809934
79VDR_23849224_ChIP-Seq_CD4+_Human0.84757901
80HIF1A_21447827_ChIP-Seq_MCF-7_Human0.84127220
81TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84039239
82NFE2_27457419_Chip-Seq_LIVER_Mouse0.83211418
83DCP1A_22483619_ChIP-Seq_HELA_Human0.82612457
84PHF8_20622853_ChIP-Seq_HELA_Human0.81634754
85LXR_22292898_ChIP-Seq_THP-1_Human0.80725587
86SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.79928206
87PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.79754652
88CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.79419966
89GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.79045941
90GATA3_24758297_ChIP-Seq_MCF-7_Human0.78855895
91* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.77709740
92* KAP1_22055183_ChIP-Seq_ESCs_Mouse0.77036381
93* CJUN_26792858_Chip-Seq_BT549_Human0.76877484
94BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.76336844
95NRF2_20460467_ChIP-Seq_MEFs_Mouse0.76009870
96NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.76009870
97ESR1_15608294_ChIP-ChIP_MCF-7_Human0.75836312
98ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.73745978
99* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.73675134
100* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.73184767
101AUTS2_25519132_ChIP-Seq_293T-REX_Human0.70933644
102GATA6_21074721_ChIP-Seq_CACO-2_Human0.70707651
103RAD21_21589869_ChIP-Seq_MESCs_Mouse0.70134160
104RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.69818678
105SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.68972405
106FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.68347907
107Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.67866264
108* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.67414570
109GATA1_19941827_ChIP-Seq_MEL_Mouse0.67062536
110SCL_19346495_ChIP-Seq_HPC-7_Human0.66745957
111ZNF263_19887448_ChIP-Seq_K562_Human0.66149870
112FOXO3_23340844_ChIP-Seq_DLD1_Human0.66082972
113ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.66064831
114GATA1_19941826_ChIP-Seq_K562_Human0.65092688
115PPAR_26484153_Chip-Seq_NCI-H1993_Human0.63571296
116EGR1_19032775_ChIP-ChIP_M12_Human0.62329875
117GATA2_19941826_ChIP-Seq_K562_Human0.62220464
118NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.61928187
119* AR_20517297_ChIP-Seq_VCAP_Human0.60907468
120GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.60501847
121SOX2_20726797_ChIP-Seq_SW620_Human0.59622641
122RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.59074769
123BRD4_27068464_Chip-Seq_AML-cells_Mouse0.58208016
124FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.57250959
125STAT3_1855785_ChIP-Seq_MESCs_Mouse0.57158708
126GATA2_21666600_ChIP-Seq_HMVEC_Human0.56729997
127RARA_24833708_ChIP-Seq_LIVER_Mouse0.56044320
128CEBPB_22108803_ChIP-Seq_LS180_Human0.54695103
129PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.53929421
130NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.52832627
131RACK7_27058665_Chip-Seq_MCF-7_Human0.52583947
132FOXA1_25552417_ChIP-Seq_VCAP_Human0.52374108
133RARB_24833708_ChIP-Seq_LIVER_Mouse0.52260076
134P63_26484246_Chip-Seq_KERATINOCYTES_Human0.51664149
135TBX20_22328084_ChIP-Seq_HEART_Mouse0.51621898
136TBX20_22080862_ChIP-Seq_HEART_Mouse0.51621898
137FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.51232449
138CDX2_20551321_ChIP-Seq_CACO-2_Human0.50360660
139SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.49946738
140BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.49824806
141ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.49380802
142CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.48303925
143LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.48264634
144AR_21909140_ChIP-Seq_LNCAP_Human0.47871223
145CSB_26484114_Chip-Seq_FIBROBLAST_Human0.47437365
146PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.47204171
147SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.46991715
148PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.46296209
149MYC_19915707_ChIP-ChIP_AK7_Human0.45736429
150* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.45350132
151TAF2_19829295_ChIP-Seq_ESCs_Human0.44949739
152ESET_19884257_ChIP-Seq_ESCs_Mouse0.44655303
153ELK3_25401928_ChIP-Seq_HUVEC_Human0.43695234
154GATA6_25053715_ChIP-Seq_YYC3_Human0.43536232
155SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.43221522

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.74754165
2MP0005360_urolithiasis7.20282866
3MP0005085_abnormal_gallbladder_physiolo5.51795789
4MP0005365_abnormal_bile_salt5.40890600
5MP0008875_abnormal_xenobiotic_pharmacok4.59827399
6MP0003806_abnormal_nucleotide_metabolis3.96316446
7MP0003252_abnormal_bile_duct3.55455750
8MP0009840_abnormal_foam_cell3.44987875
9MP0010329_abnormal_lipoprotein_level3.28530700
10MP0005332_abnormal_amino_acid2.99905047
11MP0003195_calcinosis2.87204171
12MP0005083_abnormal_biliary_tract2.65893170
13MP0001666_abnormal_nutrient_absorption2.32516542
14MP0004019_abnormal_vitamin_homeostasis2.30745049
15MP0003191_abnormal_cellular_cholesterol2.29417731
16MP0002118_abnormal_lipid_homeostasis2.04042669
17MP0000609_abnormal_liver_physiology2.03609578
18MP0002138_abnormal_hepatobiliary_system2.00405536
19MP0003011_delayed_dark_adaptation1.78187136
20MP0005319_abnormal_enzyme/_coenzyme1.78059106
21MP0003186_abnormal_redox_activity1.70507049
22MP0005584_abnormal_enzyme/coenzyme_acti1.67368313
23MP0009643_abnormal_urine_homeostasis1.57021479
24MP0001764_abnormal_homeostasis1.52334241
25MP0003868_abnormal_feces_composition1.49176319
26MP0005451_abnormal_body_composition1.41967318
27MP0003172_abnormal_lysosome_physiology1.41273140
28MP0003656_abnormal_erythrocyte_physiolo1.32440499
29MP0009697_abnormal_copulation1.28613667
30MP0003705_abnormal_hypodermis_morpholog1.28022098
31MP0000372_irregular_coat_pigmentation1.25905533
32MP0009780_abnormal_chondrocyte_physiolo1.22557656
33MP0005075_abnormal_melanosome_morpholog1.18978297
34MP0000598_abnormal_liver_morphology1.16966218
35MP0010368_abnormal_lymphatic_system1.16042817
36MP0003941_abnormal_skin_development1.12157570
37MP0000604_amyloidosis1.11589945
38MP0005636_abnormal_mineral_homeostasis1.11012623
39MP0009764_decreased_sensitivity_to1.10684598
40MP0002837_dystrophic_cardiac_calcinosis1.10402463
41MP0008438_abnormal_cutaneous_collagen1.06420495
42MP0000015_abnormal_ear_pigmentation1.06263805
43MP0005670_abnormal_white_adipose1.05427751
44MP0002254_reproductive_system_inflammat1.05327823
45MP0005408_hypopigmentation1.03768527
46MP0005647_abnormal_sex_gland1.02290443
47MP0005379_endocrine/exocrine_gland_phen1.00098455
48MP0009763_increased_sensitivity_to0.99777915
49MP0008469_abnormal_protein_level0.99528713
50MP0010386_abnormal_urinary_bladder0.97658538
51MP0009384_cardiac_valve_regurgitation0.96710391
52MP0004272_abnormal_basement_membrane0.92417863
53MP0002638_abnormal_pupillary_reflex0.91372343
54MP0002971_abnormal_brown_adipose0.89617957
55MP0002938_white_spotting0.89181474
56MP0002090_abnormal_vision0.88508830
57MP0001661_extended_life_span0.87303465
58MP0009642_abnormal_blood_homeostasis0.85917991
59MP0006036_abnormal_mitochondrial_physio0.85906608
60MP0004130_abnormal_muscle_cell0.84727855
61MP0003718_maternal_effect0.82821340
62MP0005666_abnormal_adipose_tissue0.82771180
63MP0003724_increased_susceptibility_to0.82737896
64MP0003690_abnormal_glial_cell0.82639170
65MP0002909_abnormal_adrenal_gland0.80757167
66MP0000371_diluted_coat_color0.79523794
67MP0005058_abnormal_lysosome_morphology0.79353300
68MP0001756_abnormal_urination0.78778623
69MP0001919_abnormal_reproductive_system0.76784550
70MP0002136_abnormal_kidney_physiology0.76583103
71MP0005376_homeostasis/metabolism_phenot0.75963057
72MP0001944_abnormal_pancreas_morphology0.75190597
73MP0009765_abnormal_xenobiotic_induced0.74460122
74MP0010234_abnormal_vibrissa_follicle0.74011942
75MP0000538_abnormal_urinary_bladder0.72956950
76MP0003329_amyloid_beta_deposits0.72756164
77MP0003953_abnormal_hormone_level0.72525917
78MP0005084_abnormal_gallbladder_morpholo0.71716077
79MP0003300_gastrointestinal_ulcer0.71516094
80MP0002693_abnormal_pancreas_physiology0.70671511
81MP0001324_abnormal_eye_pigmentation0.68809008
82MP0009785_altered_susceptibility_to0.67993807
83MP0002078_abnormal_glucose_homeostasis0.66865788
84MP0005220_abnormal_exocrine_pancreas0.66554663
85MP0005334_abnormal_fat_pad0.66202713
86MP0005464_abnormal_platelet_physiology0.65627431
87MP0005174_abnormal_tail_pigmentation0.64446257
88MP0000013_abnormal_adipose_tissue0.63914009
89MP0005389_reproductive_system_phenotype0.62561036
90MP0004185_abnormal_adipocyte_glucose0.62109611
91MP0000639_abnormal_adrenal_gland0.60358105
92MP0005535_abnormal_body_temperature0.59449692
93MP0004147_increased_porphyrin_level0.59250633
94MP0003638_abnormal_response/metabolism_0.59132609
95MP0005248_abnormal_Harderian_gland0.59080656
96MP0008004_abnormal_stomach_pH0.58570839
97MP0002876_abnormal_thyroid_physiology0.56494011
98MP0003436_decreased_susceptibility_to0.55958402
99MP0000249_abnormal_blood_vessel0.55915052
100MP0001853_heart_inflammation0.55527941
101MP0004043_abnormal_pH_regulation0.55527573
102MP0002132_abnormal_respiratory_system0.55128009
103MP0005165_increased_susceptibility_to0.54427399
104MP0000230_abnormal_systemic_arterial0.51866039
105MP0001881_abnormal_mammary_gland0.51344604
106MP0005410_abnormal_fertilization0.49284244
107MP0002277_abnormal_respiratory_mucosa0.48422492
108MP0002168_other_aberrant_phenotype0.48268418
109MP0005266_abnormal_metabolism0.48077252
110MP0003075_altered_response_to0.47713390
111MP0005164_abnormal_response_to0.46927648
112MP0009115_abnormal_fat_cell0.46642581
113MP0009053_abnormal_anal_canal0.46369742
114MP0005395_other_phenotype0.46318199
115MP0002295_abnormal_pulmonary_circulatio0.46062617
116MP0003279_aneurysm0.45895645
117MP0002060_abnormal_skin_morphology0.45014718
118MP0005023_abnormal_wound_healing0.44990407
119MP0006082_CNS_inflammation0.44727131
120MP0001765_abnormal_ion_homeostasis0.43994179
121MP0002928_abnormal_bile_duct0.43719262
122MP0001958_emphysema0.43658385
123MP0005595_abnormal_vascular_smooth0.42440416
124MP0001845_abnormal_inflammatory_respons0.41682313
125MP0006054_spinal_hemorrhage0.41560800
126MP0004883_abnormal_blood_vessel0.41243231
127MP0005448_abnormal_energy_balance0.40236973
128MP0005166_decreased_susceptibility_to0.40026102
129MP0008873_increased_physiological_sensi0.39983119
130MP0002135_abnormal_kidney_morphology0.39925755
131MP0005375_adipose_tissue_phenotype0.39484644
132MP0002970_abnormal_white_adipose0.38859255
133MP0001243_abnormal_dermal_layer0.38432049
134MP0002796_impaired_skin_barrier0.37398776
135MP0001533_abnormal_skeleton_physiology0.37191955

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.77375930
2Intrahepatic cholestasis (HP:0001406)6.60424986
3Deep venous thrombosis (HP:0002625)6.54165209
4Xanthomatosis (HP:0000991)6.02549586
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.81637876
6Prolonged partial thromboplastin time (HP:0003645)5.49359058
7Hypobetalipoproteinemia (HP:0003563)5.39026819
8Hyperlipoproteinemia (HP:0010980)5.10739891
9Complement deficiency (HP:0004431)4.50404915
10* Hyperammonemia (HP:0001987)4.45919065
11Hyperglycinuria (HP:0003108)4.45359281
12Abnormality of glycine metabolism (HP:0010895)4.36857716
13Abnormality of serine family amino acid metabolism (HP:0010894)4.36857716
14* Ketosis (HP:0001946)4.30020588
15Abnormality of glutamine family amino acid metabolism (HP:0010902)4.29440262
16Hypolipoproteinemia (HP:0010981)4.27073093
17Joint hemorrhage (HP:0005261)4.24779676
18Hyperglycinemia (HP:0002154)4.20418314
19Abnormality of the common coagulation pathway (HP:0010990)4.03557000
20Abnormality of sulfur amino acid metabolism (HP:0004339)4.00856523
21Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.95647767
22Abnormality of aspartate family amino acid metabolism (HP:0010899)3.94336600
23Hypoalphalipoproteinemia (HP:0003233)3.93778917
24Epidermoid cyst (HP:0200040)3.82358983
25Abnormality of fatty-acid metabolism (HP:0004359)3.71630237
26Abnormality of methionine metabolism (HP:0010901)3.70787450
27Fat malabsorption (HP:0002630)3.68423738
28Hypoglycemic coma (HP:0001325)3.66811417
29Delayed CNS myelination (HP:0002188)3.50273232
30Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.45589450
31Abnormality of the intrinsic pathway (HP:0010989)3.35089295
32Abnormality of complement system (HP:0005339)3.28705052
33Reduced antithrombin III activity (HP:0001976)3.25796460
34Abnormality of pyrimidine metabolism (HP:0004353)3.25329007
35Hypercholesterolemia (HP:0003124)3.19947751
36* Ketoacidosis (HP:0001993)3.10045772
37Vacuolated lymphocytes (HP:0001922)3.07576090
38Vascular calcification (HP:0004934)3.06409767
39Hyperbilirubinemia (HP:0002904)3.05047484
40Abnormality of nucleobase metabolism (HP:0010932)3.04055348
41Abnormality of vitamin metabolism (HP:0100508)3.02981332
42Abnormality of purine metabolism (HP:0004352)2.93418519
43Dicarboxylic aciduria (HP:0003215)2.92632822
44Abnormality of dicarboxylic acid metabolism (HP:0010995)2.92632822
45Acute encephalopathy (HP:0006846)2.90814536
46Steatorrhea (HP:0002570)2.89047622
47Abnormality of serum amino acid levels (HP:0003112)2.86718270
48Conjugated hyperbilirubinemia (HP:0002908)2.83017492
49Myocardial infarction (HP:0001658)2.81138932
50Cardiovascular calcification (HP:0011915)2.80973679
51Gout (HP:0001997)2.79790250
52Hepatocellular carcinoma (HP:0001402)2.79557344
53Generalized aminoaciduria (HP:0002909)2.77134152
54Acute necrotizing encephalopathy (HP:0006965)2.71949943
55* Metabolic acidosis (HP:0001942)2.68135140
56* Lethargy (HP:0001254)2.59634327
57Mucopolysacchariduria (HP:0008155)2.58317866
58Urinary glycosaminoglycan excretion (HP:0003541)2.58317866
59Abnormality of polysaccharide metabolism (HP:0011012)2.56987163
60Abnormality of glycosaminoglycan metabolism (HP:0004371)2.56987163
61Abnormality of mucopolysaccharide metabolism (HP:0011020)2.56987163
62Abnormal mitochondria in muscle tissue (HP:0008316)2.53935464
63Spontaneous abortion (HP:0005268)2.50577279
64Systemic lupus erythematosus (HP:0002725)2.50473560
65Amyloidosis (HP:0011034)2.47537723
66Progressive macrocephaly (HP:0004481)2.46020848
67Abnormality of vitamin B metabolism (HP:0004340)2.44457511
68Hyperinsulinemic hypoglycemia (HP:0000825)2.43253550
69Skin nodule (HP:0200036)2.38252859
70Hyperphosphaturia (HP:0003109)2.36315769
71Mitral stenosis (HP:0001718)2.34947457
72Methylmalonic aciduria (HP:0012120)2.33155426
73Hepatic necrosis (HP:0002605)2.32402121
74Hydroxyprolinuria (HP:0003080)2.31033931
75Abnormality of proline metabolism (HP:0010907)2.31033931
76Cerebral edema (HP:0002181)2.29640468
77Malnutrition (HP:0004395)2.29627563
78Megaloblastic anemia (HP:0001889)2.28704565
79Retinal atrophy (HP:0001105)2.28482382
80Irritability (HP:0000737)2.28205358
81Mitochondrial inheritance (HP:0001427)2.26350286
82Late onset (HP:0003584)2.22831938
83Pancreatitis (HP:0001733)2.22746754
84Gingival bleeding (HP:0000225)2.22559690
85Enlarged kidneys (HP:0000105)2.21598353
86Methylmalonic acidemia (HP:0002912)2.20140139
87Spastic diplegia (HP:0001264)2.19518546
88Abnormal gallbladder morphology (HP:0012437)2.17131866
89Alkalosis (HP:0001948)2.16739999
90* Vomiting (HP:0002013)2.15940258
91Proximal tubulopathy (HP:0000114)2.15675803
92Type I transferrin isoform profile (HP:0003642)2.14302693
93Acanthocytosis (HP:0001927)2.13111974
94Esophageal varix (HP:0002040)2.11668835
95Cholecystitis (HP:0001082)2.10592344
96Abnormal gallbladder physiology (HP:0012438)2.10592344
97Progressive neurologic deterioration (HP:0002344)2.10427619
98Cholelithiasis (HP:0001081)2.09557880
99Opisthotonus (HP:0002179)2.09372799
100Abnormality of the vitamin B12 metabolism (HP:0004341)2.09321999
101Nephritis (HP:0000123)2.09286477
102Hepatocellular necrosis (HP:0001404)2.09001316
103Neonatal onset (HP:0003623)2.07745674
104Brushfield spots (HP:0001088)2.07174784
105Hyperuricemia (HP:0002149)2.04256244
106Increased purine levels (HP:0004368)2.04256244
107Pigmentary retinal degeneration (HP:0001146)2.04253294
108Prolonged neonatal jaundice (HP:0006579)2.03733239
109Glomerulonephritis (HP:0000099)2.03700593
110Sensorimotor neuropathy (HP:0007141)2.03164630
111Thrombophlebitis (HP:0004418)2.02743757
112Abnormal cartilage morphology (HP:0002763)2.02563796
113Rickets (HP:0002748)2.01740743
114Conjunctival hamartoma (HP:0100780)2.00646141
115Abnormal enzyme/coenzyme activity (HP:0012379)1.98798430
116Renal Fanconi syndrome (HP:0001994)1.98612774
117Abnormality of glycolipid metabolism (HP:0010969)1.97980394
118Abnormality of liposaccharide metabolism (HP:0010968)1.97980394
119Abnormality of glycosphingolipid metabolism (HP:0004343)1.97980394
120Glycosuria (HP:0003076)1.97077273
121Abnormality of urine glucose concentration (HP:0011016)1.97077273
122Hyperglycemia (HP:0003074)1.97004134
123Hypoglycemic seizures (HP:0002173)1.96064910
124Menorrhagia (HP:0000132)1.95624000
125Abnormality of transition element cation homeostasis (HP:0011030)1.95500402
126Abnormal tarsal ossification (HP:0008369)1.94409979
127Abnormality of iron homeostasis (HP:0011031)1.93826766
128Hypophosphatemic rickets (HP:0004912)1.93146535
129Hypertriglyceridemia (HP:0002155)1.90506596
130Recurrent gram-negative bacterial infections (HP:0005420)1.88420313
131Increased CSF lactate (HP:0002490)1.88048543
132CNS demyelination (HP:0007305)1.85824357
133Elevated hepatic transaminases (HP:0002910)1.84932469
134Dysostosis multiplex (HP:0000943)1.84400188
135Abnormal urine phosphate concentration (HP:0012599)1.84309802
136Hemorrhage of the eye (HP:0011885)1.83201805
137Nausea (HP:0002018)1.81016631
138Elevated alkaline phosphatase (HP:0003155)1.78163892
139Confusion (HP:0001289)1.77537087

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.57632694
2MST45.31491089
3SIK14.41813898
4ERN14.33023712
5STK163.91817489
6FGFR43.74548060
7VRK23.48790074
8TXK3.43200150
9MAPKAPK33.12481058
10TRIB32.89956258
11BMPR1B2.86586160
12FLT32.48622175
13TRIM282.32325434
14AKT32.13432092
15EIF2AK32.08573338
16MAP3K122.03308492
17ACVR1B2.02870625
18TESK12.00093404
19TGFBR21.91280689
20NUAK11.90222128
21PKN21.87302250
22TIE11.85918617
23ERBB41.84070150
24KDR1.81877168
25EPHB11.76696862
26TAOK31.75966638
27MST1R1.74619791
28ZAK1.73728514
29TYK21.71984216
30MAPK111.70661530
31FER1.69773494
32PTK61.67687021
33VRK11.66284895
34INSRR1.64185029
35NEK11.58264378
36KIT1.55243677
37TRPM71.54818184
38PIK3CG1.54700720
39EEF2K1.52791228
40TBK11.52325230
41GRK11.50659163
42PAK41.47515760
43EIF2AK11.42448164
44MAPKAPK51.41527692
45ABL21.33370635
46NEK91.33086929
47FGFR21.32691249
48WNK41.23289670
49MET1.13322480
50PRKAA21.10197892
51LRRK21.09399909
52JAK21.06602092
53PLK31.05897834
54LIMK11.05128121
55MAPK151.04760740
56ILK1.04311283
57MAP4K11.03437045
58MAPK41.02964050
59EPHA31.02119898
60GRK61.01299880
61STK31.00118624
62OXSR10.96890861
63MAPK120.96695414
64JAK10.93833919
65EPHA20.92322778
66CSF1R0.92217772
67MAP3K70.91325492
68MAP2K30.90875648
69JAK30.88411393
70PIM20.86403963
71MAP3K100.84759546
72NME20.82437544
73MAP2K70.82325879
74STK100.81765932
75MAP3K130.80835169
76MYLK0.80428949
77YES10.78238639
78MAP4K20.77781781
79STK38L0.76303560
80NME10.75895707
81CAMK1D0.75867075
82BTK0.75479385
83CSK0.75440875
84CSNK1G30.74130175
85LATS10.73196486
86GSK3A0.72047063
87TESK20.71561123
88IRAK30.71156234
89IKBKE0.70660443
90PDGFRA0.70631768
91WNK30.70548864
92TAF10.70509771
93IKBKB0.69325337
94PBK0.67378517
95TAOK20.66997414
96MAP3K140.66194739
97MAP3K110.64597409
98FRK0.61292267
99MAP3K30.60777333
100TAOK10.60375036
101MAPK70.60306146
102DYRK1B0.59883134
103MAP2K40.59368134
104STK390.59248423
105ITK0.58640377
106CDK60.57659621
107PINK10.54951212
108PRKCQ0.54216686
109IGF1R0.52818228
110ERBB20.51484211
111PRKACG0.51313768
112FGFR30.49277966
113MAP3K50.49141631
114GRK70.49023930
115LMTK20.48310887
116CSNK1G10.48061637
117CSNK1A1L0.47777421
118ZAP700.46829504
119MATK0.45096475
120PTK20.44811228
121CSNK1G20.44225765
122PDK20.43524245
123NLK0.43266013
124PAK30.41515162
125DAPK10.40852376
126PRKACB0.40811426
127PDPK10.39652966
128PRKCZ0.39465575
129PRKAA10.38546445
130LYN0.36286742
131PAK20.35802283
132DDR20.35301444
133TGFBR10.35178263
134TEC0.34494681
135RPS6KB20.34399037
136CAMK2G0.33579292
137TTK0.33045329
138FGFR10.32382738
139BUB10.32358555
140CHUK0.32025623
141MAP3K20.30995432
142DAPK30.30979373
143ICK0.30741178
144PAK10.29810928
145CDK40.29302879
146PRKCE0.28781918
147PTK2B0.28754365
148EPHB20.28671981
149PRKG20.28187643
150PRKCG0.28092000
151MAP2K20.27641029
152SGK2230.27351228
153SGK4940.27351228
154EGFR0.27106802
155RIPK10.26911570
156PRKG10.26384067
157TSSK60.26334609
158OBSCN0.25997614
159PRKACA0.25405588
160DYRK20.25336490
161ABL10.25206379

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.01635494
2Nitrogen metabolism_Homo sapiens_hsa009103.26101916
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.24941416
4Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.95751576
5Fatty acid degradation_Homo sapiens_hsa000712.75635349
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.73402551
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.69488797
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.69121563
9Arginine biosynthesis_Homo sapiens_hsa002202.65108338
10Tryptophan metabolism_Homo sapiens_hsa003802.60004515
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.56385367
12Complement and coagulation cascades_Homo sapiens_hsa046102.48064639
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.28317599
14Propanoate metabolism_Homo sapiens_hsa006402.27076479
15Butanoate metabolism_Homo sapiens_hsa006502.23238135
16Peroxisome_Homo sapiens_hsa041462.22177354
17Fatty acid metabolism_Homo sapiens_hsa012122.15716175
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.01764211
19PPAR signaling pathway_Homo sapiens_hsa033202.00719954
20Proteasome_Homo sapiens_hsa030501.92575646
21Histidine metabolism_Homo sapiens_hsa003401.89680271
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.85415294
23Chemical carcinogenesis_Homo sapiens_hsa052041.82172139
24beta-Alanine metabolism_Homo sapiens_hsa004101.79289483
25Fatty acid elongation_Homo sapiens_hsa000621.78083512
26Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.77720907
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.76323147
28Caffeine metabolism_Homo sapiens_hsa002321.67973946
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.62562140
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.62505213
31Drug metabolism - other enzymes_Homo sapiens_hsa009831.61101869
32Retinol metabolism_Homo sapiens_hsa008301.57559771
33Sulfur metabolism_Homo sapiens_hsa009201.55452544
34Staphylococcus aureus infection_Homo sapiens_hsa051501.54544078
35Pyruvate metabolism_Homo sapiens_hsa006201.52915299
36Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.48854020
37Steroid biosynthesis_Homo sapiens_hsa001001.46858266
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.45340935
39Bile secretion_Homo sapiens_hsa049761.43489858
40Oxidative phosphorylation_Homo sapiens_hsa001901.43138801
41Selenocompound metabolism_Homo sapiens_hsa004501.42423282
42Phenylalanine metabolism_Homo sapiens_hsa003601.36173835
43Starch and sucrose metabolism_Homo sapiens_hsa005001.32966191
44Tyrosine metabolism_Homo sapiens_hsa003501.29846815
45Folate biosynthesis_Homo sapiens_hsa007901.29092884
46Carbon metabolism_Homo sapiens_hsa012001.26843763
47Biosynthesis of amino acids_Homo sapiens_hsa012301.19197785
48Cysteine and methionine metabolism_Homo sapiens_hsa002701.17449306
49Arginine and proline metabolism_Homo sapiens_hsa003301.08516198
50Cyanoamino acid metabolism_Homo sapiens_hsa004601.07486096
51ABC transporters_Homo sapiens_hsa020101.07032770
52Sulfur relay system_Homo sapiens_hsa041221.06837485
53Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.05168661
54Fat digestion and absorption_Homo sapiens_hsa049751.04705698
55* Vitamin digestion and absorption_Homo sapiens_hsa049770.99683773
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.96591225
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.94927393
58Glutathione metabolism_Homo sapiens_hsa004800.87726165
59Lysine degradation_Homo sapiens_hsa003100.83527781
60Parkinsons disease_Homo sapiens_hsa050120.83089506
61Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.78477766
62Glycerolipid metabolism_Homo sapiens_hsa005610.78292702
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.77226229
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.77169929
65Maturity onset diabetes of the young_Homo sapiens_hsa049500.76013540
66Vitamin B6 metabolism_Homo sapiens_hsa007500.74709866
67Pentose phosphate pathway_Homo sapiens_hsa000300.72449594
68Fatty acid biosynthesis_Homo sapiens_hsa000610.71020071
69One carbon pool by folate_Homo sapiens_hsa006700.68896182
70Mineral absorption_Homo sapiens_hsa049780.64958379
71Alzheimers disease_Homo sapiens_hsa050100.59620380
72Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.56560332
73Collecting duct acid secretion_Homo sapiens_hsa049660.53363256
74Sphingolipid metabolism_Homo sapiens_hsa006000.52509182
75* Metabolic pathways_Homo sapiens_hsa011000.51771858
76Huntingtons disease_Homo sapiens_hsa050160.49704191
77N-Glycan biosynthesis_Homo sapiens_hsa005100.49470379
78Vibrio cholerae infection_Homo sapiens_hsa051100.40297046
79RNA polymerase_Homo sapiens_hsa030200.33742322
80Pertussis_Homo sapiens_hsa051330.33182628
81Galactose metabolism_Homo sapiens_hsa000520.31835329
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.30475609
83Insulin resistance_Homo sapiens_hsa049310.26942610
84Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.26022370
85alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.22819792
86Fructose and mannose metabolism_Homo sapiens_hsa000510.20917738
87Prion diseases_Homo sapiens_hsa050200.16422238
88Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.12255916
89Linoleic acid metabolism_Homo sapiens_hsa005910.11632558
90Glycosaminoglycan degradation_Homo sapiens_hsa005310.11621546
91Glycerophospholipid metabolism_Homo sapiens_hsa005640.10829234
92Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.07019765
93AMPK signaling pathway_Homo sapiens_hsa041520.03292063
94Renin-angiotensin system_Homo sapiens_hsa046140.01903873
95Other glycan degradation_Homo sapiens_hsa005110.01757776
96Glucagon signaling pathway_Homo sapiens_hsa049220.01475293
97Amoebiasis_Homo sapiens_hsa05146-0.1829489
98Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1791650
99Ether lipid metabolism_Homo sapiens_hsa00565-0.1734658
100Insulin signaling pathway_Homo sapiens_hsa04910-0.1601705
101Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1452222
102Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1342230
103Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1283213
104Protein export_Homo sapiens_hsa03060-0.1280685
105Hepatitis C_Homo sapiens_hsa05160-0.1179728
106Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.1106233
107Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0501113
108Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0497031
109Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0467034
110Malaria_Homo sapiens_hsa05144-0.0334717
111Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0217108
112Protein digestion and absorption_Homo sapiens_hsa04974-0.0041926
113Lysosome_Homo sapiens_hsa04142-0.0032698

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