BTBD9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus encodes a BTB/POZ domain-containing protein. This domain is known to be involved in protein-protein interactions. Polymorphisms at this locus have been reported to be associated with susceptibility to Restless Legs Syndrome and may also be associated with Tourette Syndrome. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)6.62645892
2histone H4-K12 acetylation (GO:0043983)6.62308211
3neuronal action potential (GO:0019228)5.88819515
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.88177399
5response to pheromone (GO:0019236)5.86209181
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.50799331
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.37026280
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.35151658
9locomotory exploration behavior (GO:0035641)5.11381901
10positive regulation of action potential (GO:0045760)5.10285437
11protein localization to synapse (GO:0035418)5.09385694
12regulation of glutamate receptor signaling pathway (GO:1900449)5.03062396
13synaptic vesicle docking involved in exocytosis (GO:0016081)5.02038676
14ionotropic glutamate receptor signaling pathway (GO:0035235)4.99804092
15vocalization behavior (GO:0071625)4.91941852
16regulation of synaptic vesicle exocytosis (GO:2000300)4.90741449
17synaptic vesicle maturation (GO:0016188)4.83542510
18synaptic vesicle exocytosis (GO:0016079)4.80831197
19glutamate secretion (GO:0014047)4.65616261
20regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.50858322
21gamma-aminobutyric acid transport (GO:0015812)4.47392249
22neuron cell-cell adhesion (GO:0007158)4.44188106
23exploration behavior (GO:0035640)4.42812667
24glutamate receptor signaling pathway (GO:0007215)4.39446057
25* regulation of synaptic vesicle transport (GO:1902803)4.36723408
26synaptic transmission, glutamatergic (GO:0035249)4.32352044
27regulation of neuronal synaptic plasticity (GO:0048168)4.16347837
28neuron recognition (GO:0008038)4.14704123
29positive regulation of synapse maturation (GO:0090129)4.08366292
30axonal fasciculation (GO:0007413)3.94750484
31dendritic spine morphogenesis (GO:0060997)3.88796704
32regulation of long-term neuronal synaptic plasticity (GO:0048169)3.87866887
33layer formation in cerebral cortex (GO:0021819)3.85694352
34neurotransmitter secretion (GO:0007269)3.82425892
35cellular response to ATP (GO:0071318)3.78047947
36dendrite morphogenesis (GO:0048813)3.77573513
37neuron-neuron synaptic transmission (GO:0007270)3.76320552
38cerebellar Purkinje cell differentiation (GO:0021702)3.71109388
39regulation of excitatory postsynaptic membrane potential (GO:0060079)3.70687417
40regulation of synapse structural plasticity (GO:0051823)3.69364773
41postsynaptic membrane organization (GO:0001941)3.69015311
42regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.66911226
43positive regulation of membrane potential (GO:0045838)3.64020095
44central nervous system projection neuron axonogenesis (GO:0021952)3.63383100
45G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.61914570
46neurotransmitter-gated ion channel clustering (GO:0072578)3.61572191
47regulation of posttranscriptional gene silencing (GO:0060147)3.60615644
48regulation of gene silencing by miRNA (GO:0060964)3.60615644
49regulation of gene silencing by RNA (GO:0060966)3.60615644
50regulation of postsynaptic membrane potential (GO:0060078)3.60310190
51cilium or flagellum-dependent cell motility (GO:0001539)3.60161495
52action potential (GO:0001508)3.59479636
53regulation of vesicle fusion (GO:0031338)3.55137976
54* long-term memory (GO:0007616)3.46444783
55proline transport (GO:0015824)3.44120191
56regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.42759633
57positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.42759633
58regulation of action potential (GO:0098900)3.42221951
59regulation of synaptic plasticity (GO:0048167)3.37933978
60innervation (GO:0060384)3.37551128
61negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.37537899
62negative regulation of translation, ncRNA-mediated (GO:0040033)3.37537899
63regulation of translation, ncRNA-mediated (GO:0045974)3.37537899
64neuron maturation (GO:0042551)3.37184113
65epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.33096544
66cytoplasmic mRNA processing body assembly (GO:0033962)3.32385278
67interkinetic nuclear migration (GO:0022027)3.29698467
68behavioral response to ethanol (GO:0048149)3.29070223
69neuronal action potential propagation (GO:0019227)3.28695929
70regulation of synapse maturation (GO:0090128)3.28607968
71long-term synaptic potentiation (GO:0060291)3.28456375
72sulfation (GO:0051923)3.28434089
73auditory behavior (GO:0031223)3.27925264
74regulation of neurotransmitter secretion (GO:0046928)3.26881945
75positive regulation of neurotransmitter secretion (GO:0001956)3.25735754
76pyrimidine nucleobase catabolic process (GO:0006208)3.24324308
77positive regulation of dendritic spine morphogenesis (GO:0061003)3.23392040
78presynaptic membrane assembly (GO:0097105)3.21943284
79positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.21907548
80mechanosensory behavior (GO:0007638)3.21335883
81parturition (GO:0007567)3.20089684
82behavioral fear response (GO:0001662)3.18536724
83behavioral defense response (GO:0002209)3.18536724
84G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.17697843
85ovulation cycle (GO:0042698)3.16802325
86positive regulation of synaptic transmission, GABAergic (GO:0032230)3.16589996
87positive regulation of fatty acid beta-oxidation (GO:0032000)3.16439604
88fear response (GO:0042596)3.14821376
89nerve growth factor signaling pathway (GO:0038180)3.14637734
90adaptation of signaling pathway (GO:0023058)3.14525537
91synaptic vesicle endocytosis (GO:0048488)3.14113836
92positive regulation of potassium ion transmembrane transport (GO:1901381)3.12963292
93activation of protein kinase A activity (GO:0034199)3.11314122
94reflex (GO:0060004)3.11006921
95regulation of dendritic spine morphogenesis (GO:0061001)3.09706570
96positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.09319089
97response to auditory stimulus (GO:0010996)3.08910931
98positive regulation of mRNA catabolic process (GO:0061014)3.08397158
99cell migration in hindbrain (GO:0021535)3.07330893
100regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.07292136
101membrane depolarization (GO:0051899)3.06998809
102dendritic spine organization (GO:0097061)3.06230789
103kynurenine metabolic process (GO:0070189)3.06110648
104transmission of nerve impulse (GO:0019226)3.05787302
105neurotransmitter transport (GO:0006836)3.05457920
106gamma-aminobutyric acid signaling pathway (GO:0007214)3.05394463
107regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.04498620
108positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.04498620
109endoderm formation (GO:0001706)3.02283555
110positive regulation of dendritic spine development (GO:0060999)3.02256963
111cellular potassium ion homeostasis (GO:0030007)3.02151023
112opioid receptor signaling pathway (GO:0038003)3.01942599
113regulation of synaptic transmission, glutamatergic (GO:0051966)3.01696491
114hindbrain development (GO:0030902)3.01395156
115cell proliferation in forebrain (GO:0021846)3.01231118
116membrane depolarization during action potential (GO:0086010)2.98941329
117neuron remodeling (GO:0016322)2.98220528
118positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.97669752
119negative regulation of sodium ion transport (GO:0010766)2.97624906
120synapse assembly (GO:0007416)2.95916448
121central nervous system neuron axonogenesis (GO:0021955)2.95456314
122membrane hyperpolarization (GO:0060081)2.94309045
123indole-containing compound catabolic process (GO:0042436)2.94131167
124indolalkylamine catabolic process (GO:0046218)2.94131167
125tryptophan catabolic process (GO:0006569)2.94131167
126spinal cord motor neuron differentiation (GO:0021522)2.93931307
127positive regulation of CREB transcription factor activity (GO:0032793)2.92988096
128regulation of calcium ion-dependent exocytosis (GO:0017158)2.92240618
129membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.91813277
130protein polyglutamylation (GO:0018095)2.91525677
131glycerophospholipid catabolic process (GO:0046475)2.91434308
132urinary tract smooth muscle contraction (GO:0014848)2.89856702
133cerebellum development (GO:0021549)2.89277380
134positive regulation of neurotransmitter transport (GO:0051590)2.86524206
135regulation of neurotransmitter transport (GO:0051588)2.85910161
136nucleobase catabolic process (GO:0046113)2.85081688
137presynaptic membrane organization (GO:0097090)2.85032178
138detection of calcium ion (GO:0005513)2.84527646
139cardiovascular system development (GO:0072358)2.83029798
140learning (GO:0007612)2.82245141
141regulation of respiratory system process (GO:0044065)2.81249596
142musculoskeletal movement (GO:0050881)2.81080720
143multicellular organismal movement (GO:0050879)2.81080720
144regulation of neurotransmitter levels (GO:0001505)2.79771985
145startle response (GO:0001964)2.79645604
146kidney morphogenesis (GO:0060993)2.79191719
147regulation of dendritic spine development (GO:0060998)2.77815862
148* serotonin metabolic process (GO:0042428)2.77584456
149regulation of ARF protein signal transduction (GO:0032012)2.77013895
150negative regulation of microtubule polymerization (GO:0031115)2.77002216
151vesicle transport along microtubule (GO:0047496)2.76558691
152positive regulation of synaptic transmission (GO:0050806)2.76320109
153somite development (GO:0061053)2.76100487
154* regulation of synaptic transmission (GO:0050804)2.76075539
155cell differentiation in hindbrain (GO:0021533)2.76000591
156regulation of mesoderm development (GO:2000380)2.74486650
157cellular anion homeostasis (GO:0030002)2.73918630
158negative regulation of synaptic transmission, GABAergic (GO:0032229)2.73484376
159dopamine biosynthetic process (GO:0042416)2.73296243
160phosphatidylserine acyl-chain remodeling (GO:0036150)2.73264972
161peristalsis (GO:0030432)2.73097667
162negative regulation of systemic arterial blood pressure (GO:0003085)2.69862733
163synaptic transmission, cholinergic (GO:0007271)2.68414720
164histone H4-K5 acetylation (GO:0043981)2.68186404
165histone H4-K8 acetylation (GO:0043982)2.68186404
166positive regulation of sodium ion transmembrane transport (GO:1902307)2.67408058
167spinal cord development (GO:0021510)2.67143064
168fucose catabolic process (GO:0019317)2.64619826
169L-fucose metabolic process (GO:0042354)2.64619826
170L-fucose catabolic process (GO:0042355)2.64619826
171phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.62496376
172positive regulation of cAMP-mediated signaling (GO:0043950)2.62250382
173positive regulation of mRNA 3-end processing (GO:0031442)2.62025413
174forebrain neuron differentiation (GO:0021879)2.59291849
175phosphatidylinositol acyl-chain remodeling (GO:0036149)2.58899919
176indolalkylamine metabolic process (GO:0006586)2.58106813
177dorsal/ventral neural tube patterning (GO:0021904)2.55952732
178cell differentiation in spinal cord (GO:0021515)2.55938467
179positive regulation of fatty acid oxidation (GO:0046321)2.55460938
180positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.55036960
181positive regulation of synapse assembly (GO:0051965)2.54825470
182neuronal stem cell maintenance (GO:0097150)2.52080591
183tryptophan metabolic process (GO:0006568)2.49967623
184neuromuscular synaptic transmission (GO:0007274)2.46733875
185regulation of mRNA catabolic process (GO:0061013)2.45248273

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.40815206
2GBX2_23144817_ChIP-Seq_PC3_Human3.77807443
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.02281708
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.92773938
5* REST_21632747_ChIP-Seq_MESCs_Mouse2.81957561
6RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.81452732
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.81158550
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.59257350
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.51690511
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.51690511
11RARB_27405468_Chip-Seq_BRAIN_Mouse2.50093486
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.49120157
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.48214973
14DROSHA_22980978_ChIP-Seq_HELA_Human2.46725566
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.46107458
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.40824457
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.40274237
18MTF2_20144788_ChIP-Seq_MESCs_Mouse2.36238877
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.32257633
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.31316950
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.30982654
22* REST_18959480_ChIP-ChIP_MESCs_Mouse2.29798881
23VDR_22108803_ChIP-Seq_LS180_Human2.29119087
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.20868637
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.17366879
26EED_16625203_ChIP-ChIP_MESCs_Mouse2.08934400
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.06830880
28IKZF1_21737484_ChIP-ChIP_HCT116_Human2.00161064
29MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.96583340
30CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.89452645
31EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.88656102
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.83452739
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.77059137
34ZNF274_21170338_ChIP-Seq_K562_Hela1.69861256
35TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.64854580
36* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.64422623
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.62240213
38EWS_26573619_Chip-Seq_HEK293_Human1.55475998
39* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.51946268
40SMAD4_21799915_ChIP-Seq_A2780_Human1.49484800
41BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.46467070
42IGF1R_20145208_ChIP-Seq_DFB_Human1.41488664
43VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.40748422
44FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.39412530
45RING1B_27294783_Chip-Seq_ESCs_Mouse1.38054301
46UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.37218510
47AR_21572438_ChIP-Seq_LNCaP_Human1.34983090
48PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.30821016
49HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.30155136
50RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.29901444
51FUS_26573619_Chip-Seq_HEK293_Human1.29823223
52ZFP57_27257070_Chip-Seq_ESCs_Mouse1.29795067
53CBX2_27304074_Chip-Seq_ESCs_Mouse1.28863671
54* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.27986269
55RNF2_27304074_Chip-Seq_NSC_Mouse1.27070643
56NR3C1_23031785_ChIP-Seq_PC12_Mouse1.26602150
57RING1B_27294783_Chip-Seq_NPCs_Mouse1.26594691
58P300_19829295_ChIP-Seq_ESCs_Human1.25633772
59TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24870182
60* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.24771032
61SMAD3_21741376_ChIP-Seq_EPCs_Human1.24319558
62ER_23166858_ChIP-Seq_MCF-7_Human1.24066000
63SALL1_21062744_ChIP-ChIP_HESCs_Human1.23065382
64* AR_19668381_ChIP-Seq_PC3_Human1.22545401
65* SOX2_21211035_ChIP-Seq_LN229_Gbm1.22356023
66STAT3_23295773_ChIP-Seq_U87_Human1.22044107
67AR_25329375_ChIP-Seq_VCAP_Human1.20045086
68GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17697366
69SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17548723
70DNAJC2_21179169_ChIP-ChIP_NT2_Human1.16763379
71TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15641794
72BMI1_23680149_ChIP-Seq_NPCS_Mouse1.15337607
73ERG_21242973_ChIP-ChIP_JURKAT_Human1.14985890
74* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.14081464
75TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14024130
76POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14024130
77* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.13790044
78LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13732036
79* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11399675
80* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10275356
81TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.10058438
82SMAD4_21741376_ChIP-Seq_EPCs_Human1.09667929
83* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.08264962
84IRF1_19129219_ChIP-ChIP_H3396_Human1.07913080
85KDM2B_26808549_Chip-Seq_K562_Human1.07658010
86EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06863563
87WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.04641801
88ARNT_22903824_ChIP-Seq_MCF-7_Human1.04542939
89* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04249691
90P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03274283
91MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.02868114
92* KDM2B_26808549_Chip-Seq_REH_Human1.02183926
93TAF15_26573619_Chip-Seq_HEK293_Human1.02165436
94PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.02072023
95* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.01946158
96TCF4_23295773_ChIP-Seq_U87_Human1.00582753
97ZFP281_18757296_ChIP-ChIP_E14_Mouse1.00174871
98SMAD3_21741376_ChIP-Seq_HESCs_Human1.00124817
99* PRDM14_20953172_ChIP-Seq_ESCs_Human0.99593559
100* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99095193
101KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.99005283
102TP53_20018659_ChIP-ChIP_R1E_Mouse0.98893725
103* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98451992
104FLI1_27457419_Chip-Seq_LIVER_Mouse0.98109551
105OCT1_27270436_Chip-Seq_PROSTATE_Human0.97106355
106SMAD3_21741376_ChIP-Seq_ESCs_Human0.96726242
107CBP_20019798_ChIP-Seq_JUKART_Human0.95669438
108IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.95669438
109TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95210713
110FLI1_21867929_ChIP-Seq_TH2_Mouse0.94911970
111OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.94521126
112* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.94477919
113CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.94146375
114NRF2_20460467_ChIP-Seq_MEFs_Mouse0.93044947
115NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.93044947
116AHR_22903824_ChIP-Seq_MCF-7_Human0.92882488
117NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92733044
118* PIAS1_25552417_ChIP-Seq_VCAP_Human0.92643108
119CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92002996
120SMAD4_21741376_ChIP-Seq_HESCs_Human0.91107320
121GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89820341
122TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.89211637
123* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.88425978
124DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.87638414
125AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.86108800
126* RUNX2_22187159_ChIP-Seq_PCA_Human0.86089015
127BCAT_22108803_ChIP-Seq_LS180_Human0.85769734
128* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.84578200
129* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84436231
130TP53_16413492_ChIP-PET_HCT116_Human0.82107503
131ZFP281_27345836_Chip-Seq_ESCs_Mouse0.81743978

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.76633891
2MP0003880_abnormal_central_pattern5.20035865
3MP0003635_abnormal_synaptic_transmissio4.00881448
4MP0004270_analgesia3.32291875
5MP0002063_abnormal_learning/memory/cond3.31622980
6MP0009745_abnormal_behavioral_response3.13298969
7MP0001968_abnormal_touch/_nociception2.89923262
8MP0002064_seizures2.88157078
9MP0003646_muscle_fatigue2.79791356
10MP0002572_abnormal_emotion/affect_behav2.77651336
11MP0005423_abnormal_somatic_nervous2.72133661
12MP0004133_heterotaxia2.62596806
13MP0001986_abnormal_taste_sensitivity2.52547326
14MP0002735_abnormal_chemical_nociception2.51295124
15MP0009046_muscle_twitch2.34560196
16MP0001486_abnormal_startle_reflex2.27826348
17MP0002736_abnormal_nociception_after2.25590074
18MP0002734_abnormal_mechanical_nocicepti2.24317315
19MP0003195_calcinosis2.22141739
20MP0002272_abnormal_nervous_system2.13692487
21MP0000778_abnormal_nervous_system2.10987677
22MP0002733_abnormal_thermal_nociception2.05896948
23MP0000569_abnormal_digit_pigmentation2.03141315
24MP0001501_abnormal_sleep_pattern2.02589643
25MP0006276_abnormal_autonomic_nervous2.02272173
26MP0003787_abnormal_imprinting2.01839369
27MP0001440_abnormal_grooming_behavior1.94894079
28MP0004858_abnormal_nervous_system1.92911373
29MP0002184_abnormal_innervation1.90284732
30MP0002067_abnormal_sensory_capabilities1.89779591
31MP0002557_abnormal_social/conspecific_i1.88009222
32MP0001970_abnormal_pain_threshold1.83838310
33MP0003136_yellow_coat_color1.83194309
34MP0001502_abnormal_circadian_rhythm1.79708859
35MP0002909_abnormal_adrenal_gland1.78822841
36MP0004811_abnormal_neuron_physiology1.77816825
37MP0008961_abnormal_basal_metabolism1.77265286
38MP0002160_abnormal_reproductive_system1.75002097
39MP0003119_abnormal_digestive_system1.74963990
40MP0003183_abnormal_peptide_metabolism1.72983529
41MP0004130_abnormal_muscle_cell1.69576170
42MP0003122_maternal_imprinting1.66454579
43MP0010386_abnormal_urinary_bladder1.65580115
44MP0008569_lethality_at_weaning1.65388167
45MP0001984_abnormal_olfaction1.61732721
46MP0001485_abnormal_pinna_reflex1.61469783
47MP0005646_abnormal_pituitary_gland1.60968057
48MP0008877_abnormal_DNA_methylation1.60460372
49MP0009780_abnormal_chondrocyte_physiolo1.56279837
50MP0000955_abnormal_spinal_cord1.54327124
51MP0002638_abnormal_pupillary_reflex1.46329108
52MP0002882_abnormal_neuron_morphology1.46017813
53MP0005389_reproductive_system_phenotype1.44526003
54MP0005645_abnormal_hypothalamus_physiol1.43903091
55MP0000427_abnormal_hair_cycle1.41739430
56MP0003879_abnormal_hair_cell1.41012220
57MP0005386_behavior/neurological_phenoty1.38936978
58MP0004924_abnormal_behavior1.38936978
59MP0002822_catalepsy1.38594513
60MP0002066_abnormal_motor_capabilities/c1.32572012
61MP0010030_abnormal_orbit_morphology1.30765878
62MP0001188_hyperpigmentation1.29880275
63MP0003315_abnormal_perineum_morphology1.24964826
64MP0000534_abnormal_ureter_morphology1.23650262
65MP0003329_amyloid_beta_deposits1.22621865
66MP0006292_abnormal_olfactory_placode1.21371953
67MP0002653_abnormal_ependyma_morphology1.20702850
68MP0002152_abnormal_brain_morphology1.14199293
69MP0003011_delayed_dark_adaptation1.11458316
70MP0001905_abnormal_dopamine_level1.10739018
71MP0005551_abnormal_eye_electrophysiolog1.06694283
72MP0004510_myositis1.06542934
73MP0002069_abnormal_eating/drinking_beha1.05250815
74MP0003172_abnormal_lysosome_physiology1.05053619
75MP0005174_abnormal_tail_pigmentation1.04792469
76MP0003942_abnormal_urinary_system1.04294242
77MP0003633_abnormal_nervous_system1.03521085
78MP0000230_abnormal_systemic_arterial1.02554810
79MP0000049_abnormal_middle_ear1.01801242
80MP0004043_abnormal_pH_regulation1.01486545
81MP0005535_abnormal_body_temperature0.98926476
82MP0002089_abnormal_postnatal_growth/wei0.98863169
83MP0000631_abnormal_neuroendocrine_gland0.97809234
84MP0004885_abnormal_endolymph0.97322970
85MP0001529_abnormal_vocalization0.96514873
86MP0005448_abnormal_energy_balance0.94023924
87MP0000026_abnormal_inner_ear0.91945735
88MP0004742_abnormal_vestibular_system0.91426927
89MP0002229_neurodegeneration0.90787692
90MP0004142_abnormal_muscle_tone0.90189421
91MP0005248_abnormal_Harderian_gland0.89412295
92MP0003632_abnormal_nervous_system0.87143492
93MP0001765_abnormal_ion_homeostasis0.87081395
94MP0009250_abnormal_appendicular_skeleto0.85154723
95MP0005195_abnormal_posterior_eye0.84519647
96MP0001919_abnormal_reproductive_system0.84286457
97MP0005499_abnormal_olfactory_system0.84069607
98MP0005394_taste/olfaction_phenotype0.84069607
99MP0003303_peritoneal_inflammation0.83713002
100MP0003283_abnormal_digestive_organ0.82251404
101MP0002928_abnormal_bile_duct0.82225855
102MP0003631_nervous_system_phenotype0.80870777
103MP0003937_abnormal_limbs/digits/tail_de0.80021002
104MP0002277_abnormal_respiratory_mucosa0.79036395
105MP0001664_abnormal_digestion0.78834236
106MP0003938_abnormal_ear_development0.78786506
107MP0008872_abnormal_physiological_respon0.77645851
108MP0003959_abnormal_lean_body0.75266502
109MP0008775_abnormal_heart_ventricle0.75218697
110MP0005083_abnormal_biliary_tract0.74936784
111MP0002234_abnormal_pharynx_morphology0.73921630
112MP0002752_abnormal_somatic_nervous0.73663972
113MP0006072_abnormal_retinal_apoptosis0.73320083
114MP0001963_abnormal_hearing_physiology0.73309489
115MP0003121_genomic_imprinting0.72727440
116MP0002876_abnormal_thyroid_physiology0.71582048
117MP0005253_abnormal_eye_physiology0.71143225
118MP0003861_abnormal_nervous_system0.69250834
119MP0004085_abnormal_heartbeat0.68254215
120MP0008874_decreased_physiological_sensi0.68183002
121MP0002102_abnormal_ear_morphology0.67720046
122MP0002837_dystrophic_cardiac_calcinosis0.67249843
123MP0005171_absent_coat_pigmentation0.65911609
124MP0003075_altered_response_to0.64715955
125MP0005187_abnormal_penis_morphology0.63534341
126MP0002138_abnormal_hepatobiliary_system0.62787366
127MP0005379_endocrine/exocrine_gland_phen0.62489753
128MP0003634_abnormal_glial_cell0.61916558
129MP0002090_abnormal_vision0.61654315
130MP0009379_abnormal_foot_pigmentation0.61612423
131MP0000678_abnormal_parathyroid_gland0.61492323
132MP0001177_atelectasis0.61262213
133MP0004145_abnormal_muscle_electrophysio0.60964400
134MP0003137_abnormal_impulse_conducting0.60713647
135MP0002751_abnormal_autonomic_nervous0.60629407
136MP0003890_abnormal_embryonic-extraembry0.59484529
137MP0000015_abnormal_ear_pigmentation0.59412720

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.06554688
2Myokymia (HP:0002411)5.31884244
3Focal seizures (HP:0007359)4.69720664
4Epileptic encephalopathy (HP:0200134)4.63483907
5Visual hallucinations (HP:0002367)4.56531286
6Abnormality of pyruvate family amino acid metabolism (HP:0010915)4.52628815
7Abnormality of alanine metabolism (HP:0010916)4.52628815
8Hyperalaninemia (HP:0003348)4.52628815
9Progressive cerebellar ataxia (HP:0002073)4.17513673
10Febrile seizures (HP:0002373)4.10265452
11Abnormality of the lower motor neuron (HP:0002366)3.82167728
12Supranuclear gaze palsy (HP:0000605)3.79987171
13Pancreatic cysts (HP:0001737)3.70043169
14Atonic seizures (HP:0010819)3.69373194
15Excessive salivation (HP:0003781)3.64269311
16Drooling (HP:0002307)3.64269311
17Decreased circulating renin level (HP:0003351)3.62411093
18Hyperventilation (HP:0002883)3.56341676
19Absence seizures (HP:0002121)3.56320939
20Amblyopia (HP:0000646)3.54614874
21Abnormality of secondary sexual hair (HP:0009888)3.37108442
22Abnormality of the axillary hair (HP:0100134)3.37108442
23Congenital stationary night blindness (HP:0007642)3.36122369
24Nephronophthisis (HP:0000090)3.32234587
25Dialeptic seizures (HP:0011146)3.29079971
26True hermaphroditism (HP:0010459)3.27858127
27Pancreatic fibrosis (HP:0100732)3.27844289
28Ankle clonus (HP:0011448)3.23450354
29Molar tooth sign on MRI (HP:0002419)3.21925999
30Abnormality of midbrain morphology (HP:0002418)3.21925999
31Broad-based gait (HP:0002136)3.17956841
32Abnormal pancreas size (HP:0012094)3.10254355
33Mutism (HP:0002300)3.07105244
34Genetic anticipation (HP:0003743)3.07017245
35Clumsiness (HP:0002312)3.02356321
36Depression (HP:0000716)2.96788704
37Hyperactive renin-angiotensin system (HP:0000841)2.95801408
38Protruding tongue (HP:0010808)2.95596772
39Epileptiform EEG discharges (HP:0011182)2.94688002
40Congenital sensorineural hearing impairment (HP:0008527)2.92645222
41Papilledema (HP:0001085)2.89286444
42Generalized tonic-clonic seizures (HP:0002069)2.87217295
43Abnormal respiratory motile cilium morphology (HP:0005938)2.86484143
44Abnormal respiratory epithelium morphology (HP:0012253)2.86484143
45Birth length less than 3rd percentile (HP:0003561)2.86286857
46Poor eye contact (HP:0000817)2.84924571
47Bone cyst (HP:0012062)2.82852547
48Osteomalacia (HP:0002749)2.80696178
49EEG with generalized epileptiform discharges (HP:0011198)2.78648353
50Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.78124537
51Truncal ataxia (HP:0002078)2.77537493
52Abnormality of the renal medulla (HP:0100957)2.77215905
53Furrowed tongue (HP:0000221)2.72605105
54Irregular vertebral endplates (HP:0003301)2.71596971
55Stereotypic behavior (HP:0000733)2.66789789
56Action tremor (HP:0002345)2.66104445
57Abnormality of the vertebral endplates (HP:0005106)2.65135711
58Tubular atrophy (HP:0000092)2.64066964
59Dysmetria (HP:0001310)2.61643862
60Aplasia/Hypoplasia of the tibia (HP:0005772)2.59465378
61Absent speech (HP:0001344)2.57925417
62Impaired vibration sensation in the lower limbs (HP:0002166)2.56712738
63Gaze-evoked nystagmus (HP:0000640)2.55761003
64Failure to thrive in infancy (HP:0001531)2.55142598
65Impaired smooth pursuit (HP:0007772)2.53021090
66Hyperkalemia (HP:0002153)2.52646517
67Agitation (HP:0000713)2.51982080
68Hypsarrhythmia (HP:0002521)2.49868966
69Dysdiadochokinesis (HP:0002075)2.49306541
70Anxiety (HP:0000739)2.45675114
71Abnormal social behavior (HP:0012433)2.42581233
72Impaired social interactions (HP:0000735)2.42581233
73Hemiparesis (HP:0001269)2.40560944
74Patellar aplasia (HP:0006443)2.40353170
75Amyotrophic lateral sclerosis (HP:0007354)2.40111366
76Abnormal eating behavior (HP:0100738)2.39989154
77Pheochromocytoma (HP:0002666)2.38198337
78Type II lissencephaly (HP:0007260)2.35144397
79Large for gestational age (HP:0001520)2.34457242
80Curly hair (HP:0002212)2.33744973
81Aplasia/Hypoplasia of the patella (HP:0006498)2.33722606
82Inappropriate behavior (HP:0000719)2.32637230
83Urinary bladder sphincter dysfunction (HP:0002839)2.30304277
84Inability to walk (HP:0002540)2.30100596
85Progressive inability to walk (HP:0002505)2.29918857
86Urinary urgency (HP:0000012)2.29770637
87Tinnitus (HP:0000360)2.29135427
88Spastic gait (HP:0002064)2.28487252
89Congenital, generalized hypertrichosis (HP:0004540)2.28247517
90Gait imbalance (HP:0002141)2.28171330
91Hyperaldosteronism (HP:0000859)2.28006927
92Cystic liver disease (HP:0006706)2.26912494
93Ulnar claw (HP:0001178)2.26792860
94Abnormality of salivation (HP:0100755)2.26004940
95Abnormality of ocular smooth pursuit (HP:0000617)2.24926963
96Chorioretinal atrophy (HP:0000533)2.24489416
97Dynein arm defect of respiratory motile cilia (HP:0012255)2.23572320
98Absent/shortened dynein arms (HP:0200106)2.23572320
99Partial agenesis of the corpus callosum (HP:0001338)2.20637772
100Conjunctival hamartoma (HP:0100780)2.18994696
101Hip contracture (HP:0003273)2.17929189
102Deep palmar crease (HP:0006191)2.15738181
103Open mouth (HP:0000194)2.12676538
104Blue irides (HP:0000635)2.10120642
105Pendular nystagmus (HP:0012043)2.08479430
106Polyphagia (HP:0002591)2.08291292
107Postural instability (HP:0002172)2.05881483
108Neuroendocrine neoplasm (HP:0100634)2.04945325
109Abnormality of binocular vision (HP:0011514)2.04781246
110Diplopia (HP:0000651)2.04781246
111Large eyes (HP:0001090)2.03737905
112Cerebral inclusion bodies (HP:0100314)2.03076097
113Anophthalmia (HP:0000528)2.01354577
114Attenuation of retinal blood vessels (HP:0007843)2.00380326
115Prominent supraorbital ridges (HP:0000336)2.00338616
116Limb dystonia (HP:0002451)2.00051133
117Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.00012938
118Tented upper lip vermilion (HP:0010804)1.98469552
119Male pseudohermaphroditism (HP:0000037)1.98184190
120Lissencephaly (HP:0001339)1.97774808
121Nephrogenic diabetes insipidus (HP:0009806)1.97578109
122Bradykinesia (HP:0002067)1.96617851
123Apathy (HP:0000741)1.96071483
124Obstructive sleep apnea (HP:0002870)1.95740706
125Exotropia (HP:0000577)1.95317800
126Chronic otitis media (HP:0000389)1.95093780
127Pointed chin (HP:0000307)1.94979299
128Abolished electroretinogram (ERG) (HP:0000550)1.94006703
129Meningioma (HP:0002858)1.92738594
130Scanning speech (HP:0002168)1.92524936
131Neurodegeneration (HP:0002180)1.91996807
132Sclerocornea (HP:0000647)1.91413756
133Esotropia (HP:0000565)1.91281343
134Macroorchidism (HP:0000053)1.91090284
135Confusion (HP:0001289)1.90880889
136Hemiplegia (HP:0002301)1.90742579
137Psychosis (HP:0000709)1.90031335
138Specific learning disability (HP:0001328)1.87932887
139Medial flaring of the eyebrow (HP:0010747)1.87157234
140Hypoplasia of the brainstem (HP:0002365)1.86226624
141Aplasia/Hypoplasia of the brainstem (HP:0007362)1.86226624
142Diminished motivation (HP:0000745)1.85987922
143Hamartoma of the eye (HP:0010568)1.85367475
144Neurofibrillary tangles (HP:0002185)1.84850873
145Annular pancreas (HP:0001734)1.83800965
146Fair hair (HP:0002286)1.83034217
147Abnormality of the nasal septum (HP:0000419)1.82626406
148Generalized hypopigmentation of hair (HP:0011358)1.82511721
149Limited hip movement (HP:0008800)1.82007948
150Macroglossia (HP:0000158)1.81975165
151Optic nerve hypoplasia (HP:0000609)1.81443168
152Decreased electroretinogram (ERG) amplitude (HP:0000654)1.81352862
153Focal dystonia (HP:0004373)1.81136380
154Lower limb muscle weakness (HP:0007340)1.80128480
155Sleep apnea (HP:0010535)1.80016865
156Torticollis (HP:0000473)1.79936748
157Abnormality of the renal cortex (HP:0011035)1.79675994
158Abnormality of the corticospinal tract (HP:0002492)1.79000487
159Tubulointerstitial fibrosis (HP:0005576)1.78858925
160Hypoventilation (HP:0002791)1.78622224
161Ventricular fibrillation (HP:0001663)1.78466648
162Insomnia (HP:0100785)1.78064765
163Abnormality of calcium-phosphate metabolism (HP:0100530)1.76802511
164Absent hair (HP:0002298)1.76611303
165Increased corneal curvature (HP:0100692)1.76401127
166Keratoconus (HP:0000563)1.76401127
167Spinal muscular atrophy (HP:0007269)1.75737922
168Short hallux (HP:0010109)1.75650993
169Hypoplastic ischia (HP:0003175)1.75649666
170Decreased central vision (HP:0007663)1.75054956
171Mesangial abnormality (HP:0001966)1.74469907
172Concave nail (HP:0001598)1.73712668
173Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.73663038
174Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.72987127
175Abnormal drinking behavior (HP:0030082)1.69802093

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.77504393
2FRK4.71097618
3ACVR1B4.30407286
4MARK14.14828829
5EPHA43.79979424
6ADRBK23.64365543
7MAP3K93.54839649
8PNCK3.51278091
9BMPR1B3.23887811
10MAP3K42.67057279
11MAP2K72.65194384
12TLK12.57686213
13MINK12.44053087
14DAPK22.43279443
15TNIK2.32881855
16ZAK2.30680477
17CASK2.25832044
18SIK22.19357365
19NTRK22.06974989
20GRK12.03702343
21PRKD31.92589556
22FES1.89084185
23KSR11.84640791
24PAK61.83432503
25PINK11.80593661
26RIPK41.80190384
27MAPK131.79640915
28LMTK21.76750610
29DAPK11.63481240
30KSR21.62682500
31MAP3K21.59799636
32PRPF4B1.56403546
33TGFBR11.54528171
34CDK51.50498152
35MAP3K121.49390740
36NTRK11.46498907
37GRK51.46080780
38MAP2K41.42058808
39UHMK11.39731243
40CAMKK11.27252291
41MARK21.23952920
42TYRO31.22154680
43STK381.09776810
44MAP3K131.06617749
45WNK41.06154823
46RPS6KA61.01018679
47NEK91.00963065
48PRKCG0.99181834
49PTK2B0.99077970
50MKNK20.96558822
51CAMK10.96274577
52WNK30.96058964
53PIK3CA0.93743263
54DYRK1A0.92323185
55RPS6KA40.90693124
56PLK20.89097938
57CDK190.86635435
58CAMK2A0.86525052
59NME10.84802851
60CSNK1G20.81771715
61TRPM70.81624812
62SIK30.79725894
63PHKG20.79639796
64PHKG10.79639796
65SGK2230.77877863
66SGK4940.77877863
67PRKCQ0.77465172
68TAOK10.76711302
69CAMK1D0.76128105
70RPS6KA50.75466413
71ICK0.74100745
72MAP3K70.73612336
73MAP2K10.73291929
74RET0.72991248
75IRAK10.72465231
76SCYL20.69498581
77RAF10.66972934
78MAP3K10.66930557
79PAK30.66290424
80CAMK40.65087643
81CAMK2B0.64864973
82SGK10.64375050
83CDK180.64205573
84DYRK20.64104449
85NEK20.64034844
86ERBB20.61229959
87STK110.60265078
88SGK20.59810104
89CDK150.59528926
90PKN10.59471327
91HIPK20.58054672
92PRKCZ0.57373635
93CDK140.55135732
94PRKCH0.54421048
95TAOK20.54302152
96BMPR20.53481072
97PDGFRB0.52873656
98CDK30.52660312
99CDK11A0.52451661
100FGR0.52126059
101IRAK40.52027392
102PDK10.51275265
103CAMK1G0.50933007
104CHUK0.50238297
105CDC42BPA0.49517927
106TAOK30.48583078
107TIE10.48570112
108INSRR0.46630741
109PRKACA0.45286162
110NUAK10.44500586
111RPS6KA20.43498092
112RPS6KA30.43217496
113FYN0.42987680
114SGK30.40809181
115MAP2K20.40801669
116PRKCE0.40670443
117PLK40.40453139
118FER0.40182329
119BRAF0.38941150
120DYRK30.38650127
121CAMKK20.38635563
122GRK60.38262321
123MAPK120.37963918
124WNK10.37148681
125GRK70.36491128
126SYK0.35842606
127MAPK150.35786367
128AKT30.35301706
129MAPK100.34930148
130PRKAA10.34896240
131ERBB30.33771313
132PRKD20.33377352
133ALK0.33178704
134PDPK10.32909240
135ARAF0.32256380
136PDGFRA0.31709810
137ADRBK10.30345189
138DAPK30.30138575
139OXSR10.30109015
140MELK0.28906010
141PRKCB0.28678910
142CSNK1D0.27895540
143MAPK90.27856365
144EPHB20.27752021
145IKBKB0.25823581
146CSNK1A10.24518316
147MAP3K110.24278277
148PRKCA0.24118368
149PRKACG0.24010376
150PRKAA20.22067641
151TEC0.21587040
152MUSK0.21341329

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.46034137
2Synaptic vesicle cycle_Homo sapiens_hsa047212.88752171
3Circadian entrainment_Homo sapiens_hsa047132.79054018
4Long-term potentiation_Homo sapiens_hsa047202.71649762
5Linoleic acid metabolism_Homo sapiens_hsa005912.66376865
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.57334488
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.50868236
8Glutamatergic synapse_Homo sapiens_hsa047242.49940611
9Olfactory transduction_Homo sapiens_hsa047402.45100517
10Nitrogen metabolism_Homo sapiens_hsa009102.42841296
11GABAergic synapse_Homo sapiens_hsa047272.38758022
12Amphetamine addiction_Homo sapiens_hsa050312.38591274
13Morphine addiction_Homo sapiens_hsa050322.32645179
14Insulin secretion_Homo sapiens_hsa049112.28543174
15Dopaminergic synapse_Homo sapiens_hsa047282.18415962
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.14815720
17Selenocompound metabolism_Homo sapiens_hsa004502.03507812
18Aldosterone synthesis and secretion_Homo sapiens_hsa049252.01182905
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.94693357
20Cholinergic synapse_Homo sapiens_hsa047251.94480164
21Salivary secretion_Homo sapiens_hsa049701.93379993
22Ether lipid metabolism_Homo sapiens_hsa005651.86137862
23Taste transduction_Homo sapiens_hsa047421.81106255
24Long-term depression_Homo sapiens_hsa047301.72975491
25Renin secretion_Homo sapiens_hsa049241.70846610
26Cocaine addiction_Homo sapiens_hsa050301.69523129
27Oxytocin signaling pathway_Homo sapiens_hsa049211.63391436
28Gastric acid secretion_Homo sapiens_hsa049711.63323105
29Serotonergic synapse_Homo sapiens_hsa047261.63097158
30Type II diabetes mellitus_Homo sapiens_hsa049301.56804752
31Calcium signaling pathway_Homo sapiens_hsa040201.53477652
32GnRH signaling pathway_Homo sapiens_hsa049121.49720358
33Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.48708597
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.44970934
35Intestinal immune network for IgA production_Homo sapiens_hsa046721.39351988
36Phototransduction_Homo sapiens_hsa047441.36350946
37Gap junction_Homo sapiens_hsa045401.33723648
38Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.31293768
39Axon guidance_Homo sapiens_hsa043601.30827163
40Estrogen signaling pathway_Homo sapiens_hsa049151.30374817
41cAMP signaling pathway_Homo sapiens_hsa040241.28733429
42Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.27591854
43Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.26906110
44Tryptophan metabolism_Homo sapiens_hsa003801.23417795
45Phosphatidylinositol signaling system_Homo sapiens_hsa040701.22366652
46Glioma_Homo sapiens_hsa052141.17437785
47ErbB signaling pathway_Homo sapiens_hsa040121.15826370
48cGMP-PKG signaling pathway_Homo sapiens_hsa040221.13645973
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.13088282
50Collecting duct acid secretion_Homo sapiens_hsa049661.11805642
51Butanoate metabolism_Homo sapiens_hsa006501.11108360
52ABC transporters_Homo sapiens_hsa020101.06400107
53Melanogenesis_Homo sapiens_hsa049161.00967699
54Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.99036222
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98676980
56Fatty acid biosynthesis_Homo sapiens_hsa000610.97782900
57Circadian rhythm_Homo sapiens_hsa047100.95474615
58Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.93977031
59Neurotrophin signaling pathway_Homo sapiens_hsa047220.90665556
60Phospholipase D signaling pathway_Homo sapiens_hsa040720.90508323
61Vascular smooth muscle contraction_Homo sapiens_hsa042700.89702992
62Steroid hormone biosynthesis_Homo sapiens_hsa001400.86697599
63Vibrio cholerae infection_Homo sapiens_hsa051100.86648900
64Choline metabolism in cancer_Homo sapiens_hsa052310.85707324
65Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.84909245
66Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.84611540
67Melanoma_Homo sapiens_hsa052180.83193924
68Arachidonic acid metabolism_Homo sapiens_hsa005900.83158475
69VEGF signaling pathway_Homo sapiens_hsa043700.82216930
70Dorso-ventral axis formation_Homo sapiens_hsa043200.80828708
71Pancreatic secretion_Homo sapiens_hsa049720.80332010
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77560204
73Chemical carcinogenesis_Homo sapiens_hsa052040.77125764
74Caffeine metabolism_Homo sapiens_hsa002320.76159385
75Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.75913265
76Carbohydrate digestion and absorption_Homo sapiens_hsa049730.74811879
77Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.74352422
78Sulfur relay system_Homo sapiens_hsa041220.72679984
79MAPK signaling pathway_Homo sapiens_hsa040100.71906583
80Basal cell carcinoma_Homo sapiens_hsa052170.71328989
81mTOR signaling pathway_Homo sapiens_hsa041500.71287620
82Histidine metabolism_Homo sapiens_hsa003400.71107725
83Cyanoamino acid metabolism_Homo sapiens_hsa004600.70908601
84Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.68878199
85Glucagon signaling pathway_Homo sapiens_hsa049220.68445663
86Oocyte meiosis_Homo sapiens_hsa041140.67874205
87Thyroid hormone synthesis_Homo sapiens_hsa049180.67438779
88Hedgehog signaling pathway_Homo sapiens_hsa043400.66534079
89Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65458158
90Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.64811236
91Asthma_Homo sapiens_hsa053100.64598989
92Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.64002600
93Endometrial cancer_Homo sapiens_hsa052130.63824072
94Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.61530295
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60993952
96Glycerolipid metabolism_Homo sapiens_hsa005610.60801107
97Type I diabetes mellitus_Homo sapiens_hsa049400.60775096
98Maturity onset diabetes of the young_Homo sapiens_hsa049500.60720498
99Retinol metabolism_Homo sapiens_hsa008300.60672165
100Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60417922
101Ras signaling pathway_Homo sapiens_hsa040140.58865818
102Alcoholism_Homo sapiens_hsa050340.57344408
103Prolactin signaling pathway_Homo sapiens_hsa049170.56279560
104Inositol phosphate metabolism_Homo sapiens_hsa005620.56147133
105Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.55905991
106Wnt signaling pathway_Homo sapiens_hsa043100.55273564
107Chemokine signaling pathway_Homo sapiens_hsa040620.54445939
108Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54427251
109Insulin signaling pathway_Homo sapiens_hsa049100.53389141
110Colorectal cancer_Homo sapiens_hsa052100.53048291
111Renal cell carcinoma_Homo sapiens_hsa052110.52521705
112Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.52431031
113Endocytosis_Homo sapiens_hsa041440.52269317
114Non-small cell lung cancer_Homo sapiens_hsa052230.52232461
115Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51731488
116Rap1 signaling pathway_Homo sapiens_hsa040150.50632314
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.50173775
118Prion diseases_Homo sapiens_hsa050200.49712911
119Bile secretion_Homo sapiens_hsa049760.48697904
120Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47592850
121Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.45791485
122Dilated cardiomyopathy_Homo sapiens_hsa054140.45191516
123Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.44432682
124Adipocytokine signaling pathway_Homo sapiens_hsa049200.41377746
125Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40959346
126B cell receptor signaling pathway_Homo sapiens_hsa046620.38707139
127Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38567367
128T cell receptor signaling pathway_Homo sapiens_hsa046600.38541273
129Starch and sucrose metabolism_Homo sapiens_hsa005000.38090711
130Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.37648395
131Cardiac muscle contraction_Homo sapiens_hsa042600.36694599
132Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.36081691
133Hippo signaling pathway_Homo sapiens_hsa043900.35935407
134Primary bile acid biosynthesis_Homo sapiens_hsa001200.35741435
135Peroxisome_Homo sapiens_hsa041460.34583493
136Platelet activation_Homo sapiens_hsa046110.34497996
137African trypanosomiasis_Homo sapiens_hsa051430.34254141
138Glycerophospholipid metabolism_Homo sapiens_hsa005640.33981226
139Fat digestion and absorption_Homo sapiens_hsa049750.33062558
140TGF-beta signaling pathway_Homo sapiens_hsa043500.32907912
141Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.32157848
142beta-Alanine metabolism_Homo sapiens_hsa004100.31681109
143Ovarian steroidogenesis_Homo sapiens_hsa049130.29692372
144Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.28244820
145Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28157235

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