BTBD6P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)7.33449554
2B cell receptor signaling pathway (GO:0050853)7.08855322
3regulation of B cell receptor signaling pathway (GO:0050855)6.41408057
4regulation of gamma-delta T cell activation (GO:0046643)5.38210751
5regulation of gamma-delta T cell differentiation (GO:0045586)5.28316994
6positive regulation of B cell differentiation (GO:0045579)5.17413778
7positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.17249282
8regulation of B cell differentiation (GO:0045577)4.90161922
9positive thymic T cell selection (GO:0045059)4.54221513
10negative regulation of cell killing (GO:0031342)4.49861041
11negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.49861041
12B cell homeostasis (GO:0001782)4.38365347
13CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)4.33877907
14antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.33128329
15regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.31621409
16antigen processing and presentation of endogenous antigen (GO:0019883)4.27975336
17modulation by symbiont of host immune response (GO:0052553)4.26065171
18positive regulation by symbiont of host defense response (GO:0052509)4.26065171
19modulation by symbiont of host defense response (GO:0052031)4.26065171
20modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.26065171
21modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.26065171
22positive regulation by organism of defense response of other organism involved in symbiotic interact4.26065171
23immunoglobulin mediated immune response (GO:0016064)4.15952762
24antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.13460812
25negative thymic T cell selection (GO:0045060)3.97342037
26potassium ion export (GO:0071435)3.93176724
27T cell migration (GO:0072678)3.89924916
28B cell proliferation (GO:0042100)3.86408125
29antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.80478706
30histone H3-K36 demethylation (GO:0070544)3.80380326
31positive T cell selection (GO:0043368)3.79628434
32regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.78162274
33negative T cell selection (GO:0043383)3.77985931
34macrophage activation involved in immune response (GO:0002281)3.77945416
35thymic T cell selection (GO:0045061)3.70243552
36positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.65367786
37defense response to protozoan (GO:0042832)3.65061554
38regulation of interferon-beta biosynthetic process (GO:0045357)3.64629235
39T cell selection (GO:0045058)3.61527972
40positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.51347440
41antigen receptor-mediated signaling pathway (GO:0050851)3.47054730
42tolerance induction (GO:0002507)3.44885807
43regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.44436479
44response to protozoan (GO:0001562)3.44327989
45germinal center formation (GO:0002467)3.37670487
46T cell lineage commitment (GO:0002360)3.36708153
47NIK/NF-kappaB signaling (GO:0038061)3.33939362
48positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.33754873
49positive regulation of protein homooligomerization (GO:0032464)3.32603020
50regulation of antigen processing and presentation (GO:0002577)3.30321371
51detection of bacterium (GO:0016045)3.28381141
52membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.25592154
53detection of other organism (GO:0098543)3.24591545
54cellular extravasation (GO:0045123)3.22978326
55regulation of B cell proliferation (GO:0030888)3.20399438
56interferon-gamma-mediated signaling pathway (GO:0060333)3.18815266
57negative regulation of B cell proliferation (GO:0030889)3.17856124
58response to interleukin-15 (GO:0070672)3.16743130
59positive regulation of interferon-alpha production (GO:0032727)3.16709487
60response to type I interferon (GO:0034340)3.15253350
61positive regulation of granulocyte differentiation (GO:0030854)3.12121622
62cellular response to type I interferon (GO:0071357)3.10386309
63type I interferon signaling pathway (GO:0060337)3.10386309
64B cell mediated immunity (GO:0019724)3.10197037
65regulation of protein heterodimerization activity (GO:0043497)3.09331812
66lymphocyte homeostasis (GO:0002260)3.09316916
67antigen processing and presentation via MHC class Ib (GO:0002475)3.07074766
68cranial suture morphogenesis (GO:0060363)3.04118172
69cellular response to interleukin-15 (GO:0071350)3.03605275
70production of molecular mediator involved in inflammatory response (GO:0002532)3.03507824
71respiratory burst (GO:0045730)3.02270990
72regulation of mast cell activation (GO:0033003)3.01203014
73positive regulation of B cell proliferation (GO:0030890)3.00777361
74negative regulation of toll-like receptor signaling pathway (GO:0034122)3.00468923
75positive regulation of B cell activation (GO:0050871)3.00353834
76regulation of interferon-alpha production (GO:0032647)2.97477612
77negative regulation of T cell mediated immunity (GO:0002710)2.96679254
78positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.96271894
79negative regulation of lymphocyte mediated immunity (GO:0002707)2.94071280
80leukocyte aggregation (GO:0070486)2.92941108
81regulation of alpha-beta T cell proliferation (GO:0046640)2.91863426
82natural killer cell differentiation (GO:0001779)2.86481633
83negative regulation of DNA repair (GO:0045738)2.83510969
84positive regulation of mast cell activation (GO:0033005)2.82015239
85regulation of mast cell degranulation (GO:0043304)2.81616102
86regulation of MHC class I biosynthetic process (GO:0045343)2.79881945
87negative regulation of leukocyte mediated immunity (GO:0002704)2.79141233
88membrane repolarization during action potential (GO:0086011)2.77851729
89response to host immune response (GO:0052572)2.77455296
90response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.77455296
91T cell homeostasis (GO:0043029)2.77128775
92T cell costimulation (GO:0031295)2.76066085
93determination of adult lifespan (GO:0008340)2.73761317
94negative regulation of innate immune response (GO:0045824)2.73251645
95regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.72245690
96regulation of B cell apoptotic process (GO:0002902)2.71869933
97lymphocyte costimulation (GO:0031294)2.71757049
98negative regulation of T-helper cell differentiation (GO:0045623)2.71670266
99negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.71670266
100leukocyte homeostasis (GO:0001776)2.71150207

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.74285789
2MYC_22102868_ChIP-Seq_BL_Human4.86967541
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.76930756
4VDR_21846776_ChIP-Seq_THP-1_Human3.48725399
5E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human3.45936894
6SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.44268929
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.43865731
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.41212297
9VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human3.24346540
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.22061512
11MAF_26560356_Chip-Seq_TH1_Human2.74249194
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.72606730
13MYB_26560356_Chip-Seq_TH2_Human2.72405077
14VDR_24763502_ChIP-Seq_THP-1_Human2.53941371
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.50815770
16SPI1_23547873_ChIP-Seq_NB4_Human2.35145270
17MYB_26560356_Chip-Seq_TH1_Human2.32364724
18UTX_26944678_Chip-Seq_JUKART_Human2.32133911
19RUNX_20019798_ChIP-Seq_JUKART_Human2.32013926
20CIITA_25753668_ChIP-Seq_RAJI_Human2.31841119
21ELF1_17652178_ChIP-ChIP_JURKAT_Human2.30840817
22SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.26648816
23STAT4_19710469_ChIP-ChIP_TH1__Mouse2.25546884
24IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.18006849
25FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.17327159
26SCL_19346495_ChIP-Seq_HPC-7_Human2.16661414
27IRF8_27001747_Chip-Seq_BMDM_Mouse2.15343587
28MAF_26560356_Chip-Seq_TH2_Human2.06483921
29KDM2B_26808549_Chip-Seq_SUP-B15_Human2.06108737
30SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.94489816
31KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.92144680
32TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.89690604
33RUNX1_22412390_ChIP-Seq_EML_Mouse1.88446884
34RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.85223081
35NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.81337503
36KDM2B_26808549_Chip-Seq_DND41_Human1.80649238
37GATA1_22025678_ChIP-Seq_K562_Human1.79595701
38TCF7_22412390_ChIP-Seq_EML_Mouse1.78756120
39BRD4_27068464_Chip-Seq_AML-cells_Mouse1.78350962
40SPI1_23127762_ChIP-Seq_K562_Human1.74162393
41KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.68640560
42STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.67210856
43EGR1_19374776_ChIP-ChIP_THP-1_Human1.64449969
44TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.61425033
45NOTCH1_21737748_ChIP-Seq_TLL_Human1.61009310
46GATA3_27048872_Chip-Seq_THYMUS_Human1.58185124
47FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.55160416
48MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.54850734
49MYB_21317192_ChIP-Seq_ERMYB_Mouse1.52106690
50ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.50862075
51BCOR_27268052_Chip-Seq_Bcells_Human1.49884347
52BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.48422564
53SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.44876550
54NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.44346735
55NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.41052579
56PU.1_20513432_ChIP-Seq_Bcells_Mouse1.38748565
57TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.37962177
58NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.37240690
59GATA1_19941827_ChIP-Seq_MEL_Mouse1.37172626
60LXR_22292898_ChIP-Seq_THP-1_Human1.35712141
61GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24696268
62BCL6_27268052_Chip-Seq_Bcells_Human1.24193799
63ELK3_25401928_ChIP-Seq_HUVEC_Human1.23438225
64RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.20882516
65IKZF1_21737484_ChIP-ChIP_HCT116_Human1.20676447
66GATA1_22383799_ChIP-Seq_G1ME_Mouse1.19189133
67PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12897247
68GATA2_22383799_ChIP-Seq_G1ME_Mouse1.11665943
69PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08963959
70LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.08166621
71P300_27268052_Chip-Seq_Bcells_Human1.07828650
72KDM2B_26808549_Chip-Seq_JURKAT_Human1.06238945
73GATA1_19941826_ChIP-Seq_K562_Human1.05478929
74VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.04881315
75CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04592290
76ELF1_20517297_ChIP-Seq_JURKAT_Human1.02948638
77GATA3_26560356_Chip-Seq_TH2_Human1.02771357
78SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.01622090
79PU_27001747_Chip-Seq_BMDM_Mouse1.01610158
80PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01295166
81FOXP3_21729870_ChIP-Seq_TREG_Human1.01004103
82PHF8_20622854_ChIP-Seq_HELA_Human0.96124884
83KDM5A_27292631_Chip-Seq_BREAST_Human0.95102154
84SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.94527961
85CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94410328
86CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94343153
87SA1_27219007_Chip-Seq_ERYTHROID_Human0.93289067
88NCOR1_26117541_ChIP-Seq_K562_Human0.93253769
89P68_20966046_ChIP-Seq_HELA_Human0.92515174
90CTCF_21964334_ChIP-Seq_BJAB-B_Human0.92470692
91CTCF_27219007_Chip-Seq_ERYTHROID_Human0.92342023
92GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91018675
93RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90466253
94SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89375857
95YY1_21170310_ChIP-Seq_MESCs_Mouse0.88427325
96VDR_24787735_ChIP-Seq_THP-1_Human0.87948055
97LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.86596463
98ERG_20887958_ChIP-Seq_HPC-7_Mouse0.85997714
99FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85940051
100Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.84915901

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.00792068
2MP0003763_abnormal_thymus_physiology3.80976296
3MP0001800_abnormal_humoral_immune3.72654490
4MP0000685_abnormal_immune_system3.52379194
5MP0003303_peritoneal_inflammation3.35010177
6MP0001790_abnormal_immune_system3.33464774
7MP0005387_immune_system_phenotype3.33464774
8MP0005671_abnormal_response_to3.08031123
9MP0002452_abnormal_antigen_presenting2.91489838
10MP0005000_abnormal_immune_tolerance2.85483452
11MP0002420_abnormal_adaptive_immunity2.71777231
12MP0002723_abnormal_immune_serum2.68169661
13MP0001819_abnormal_immune_cell2.67462118
14MP0003436_decreased_susceptibility_to2.48082706
15MP0002398_abnormal_bone_marrow2.46565927
16MP0005377_hearing/vestibular/ear_phenot2.46216674
17MP0003878_abnormal_ear_physiology2.46216674
18MP0002396_abnormal_hematopoietic_system2.39029121
19MP0000716_abnormal_immune_system2.28830225
20MP0005310_abnormal_salivary_gland2.26766341
21MP0005025_abnormal_response_to2.23942037
22MP0000689_abnormal_spleen_morphology2.21882422
23MP0005075_abnormal_melanosome_morpholog2.21827558
24MP0002419_abnormal_innate_immunity2.19364609
25MP0002138_abnormal_hepatobiliary_system2.10161089
26MP0002405_respiratory_system_inflammati2.07962433
27MP0002722_abnormal_immune_system2.07873543
28MP0008260_abnormal_autophagy2.07417768
29MP0003300_gastrointestinal_ulcer2.03107132
30MP0001873_stomach_inflammation1.94282159
31MP0002429_abnormal_blood_cell1.90068439
32MP0005464_abnormal_platelet_physiology1.86201573
33MP0000703_abnormal_thymus_morphology1.85037283
34MP0009333_abnormal_splenocyte_physiolog1.77902227
35MP0002148_abnormal_hypersensitivity_rea1.77837272
36MP0003183_abnormal_peptide_metabolism1.77177590
37MP0003172_abnormal_lysosome_physiology1.77154888
38MP0008057_abnormal_DNA_replication1.71865526
39MP0009785_altered_susceptibility_to1.69384809
40MP0003724_increased_susceptibility_to1.58354196
41MP0003787_abnormal_imprinting1.56303306
42MP0004381_abnormal_hair_follicle1.52775224
43MP0000015_abnormal_ear_pigmentation1.51626186
44MP0001845_abnormal_inflammatory_respons1.47474357
45MP0001663_abnormal_digestive_system1.35579040
46MP0010155_abnormal_intestine_physiology1.26431010
47MP0002132_abnormal_respiratory_system1.26341385
48MP0002928_abnormal_bile_duct1.25166666
49MP0002166_altered_tumor_susceptibility1.23367608
50MP0005058_abnormal_lysosome_morphology1.20905306
51MP0000371_diluted_coat_color1.11847797
52MP0003091_abnormal_cell_migration1.11370637
53MP0004947_skin_inflammation1.11215035
54MP0005451_abnormal_body_composition1.09585829
55MP0000569_abnormal_digit_pigmentation1.07717455
56MP0008995_early_reproductive_senescence1.05454787
57MP0001853_heart_inflammation1.03778211
58MP0008961_abnormal_basal_metabolism1.02557660
59MP0008469_abnormal_protein_level1.00388306
60MP0006035_abnormal_mitochondrial_morpho0.99850003
61MP0002254_reproductive_system_inflammat0.98124160
62MP0004808_abnormal_hematopoietic_stem0.97880678
63MP0005381_digestive/alimentary_phenotyp0.97614168
64MP0003866_abnormal_defecation0.97607241
65MP0002009_preneoplasia0.93594019
66MP0002019_abnormal_tumor_incidence0.91306002
67MP0008877_abnormal_DNA_methylation0.88667980
68MP0000490_abnormal_crypts_of0.86351476
69MP0001919_abnormal_reproductive_system0.86042443
70MP0008874_decreased_physiological_sensi0.84523764
71MP0001348_abnormal_lacrimal_gland0.83455977
72MP0003077_abnormal_cell_cycle0.83107486
73MP0001533_abnormal_skeleton_physiology0.82189197
74MP0005645_abnormal_hypothalamus_physiol0.79907384
75MP0005174_abnormal_tail_pigmentation0.77568825
76MP0000465_gastrointestinal_hemorrhage0.76072025
77MP0003191_abnormal_cellular_cholesterol0.75324684
78MP0009764_decreased_sensitivity_to0.71451683
79MP0006082_CNS_inflammation0.69660592
80MP0005408_hypopigmentation0.68987555
81MP0009278_abnormal_bone_marrow0.68811379
82MP0002163_abnormal_gland_morphology0.68420456
83MP0000470_abnormal_stomach_morphology0.66053771
84MP0001986_abnormal_taste_sensitivity0.65676826
85MP0002006_tumorigenesis0.64562626
86MP0008004_abnormal_stomach_pH0.63873071
87MP0003045_fibrosis0.61148851
88MP0000313_abnormal_cell_death0.59355725
89MP0003646_muscle_fatigue0.59207370
90MP0001545_abnormal_hematopoietic_system0.59202103
91MP0005397_hematopoietic_system_phenotyp0.59202103
92MP0002653_abnormal_ependyma_morphology0.56541350
93MP0005379_endocrine/exocrine_gland_phen0.55666710
94MP0002136_abnormal_kidney_physiology0.53412574
95MP0000858_altered_metastatic_potential0.52739730
96MP0003111_abnormal_nucleus_morphology0.52357507
97MP0005621_abnormal_cell_physiology0.52064451
98MP0002693_abnormal_pancreas_physiology0.50874117
99MP0000350_abnormal_cell_proliferation0.49754273
100MP0009115_abnormal_fat_cell0.49473280

Predicted human phenotypes

RankGene SetZ-score
1Gastrointestinal stroma tumor (HP:0100723)6.61642352
2Agammaglobulinemia (HP:0004432)5.88207386
3Recurrent sinusitis (HP:0011108)5.05354763
4IgM deficiency (HP:0002850)4.97395817
5Lymphopenia (HP:0001888)4.89415737
6Recurrent bacterial skin infections (HP:0005406)4.80521369
7Mediastinal lymphadenopathy (HP:0100721)4.68168304
8Recurrent bronchitis (HP:0002837)4.61854052
9Meningitis (HP:0001287)4.60880818
10Abnormality of cells of the lymphoid lineage (HP:0012140)4.56313337
11Abnormal delayed hypersensitivity skin test (HP:0002963)4.53697990
12Recurrent abscess formation (HP:0002722)4.51840819
13Colitis (HP:0002583)4.45088087
14Recurrent viral infections (HP:0004429)4.31270210
15Panhypogammaglobulinemia (HP:0003139)4.20147958
16Vasculitis (HP:0002633)4.16457162
17Chronic mucocutaneous candidiasis (HP:0002728)3.95947549
18Recurrent cutaneous fungal infections (HP:0011370)3.95947549
19Recurrent fungal infections (HP:0002841)3.95397321
20Cellulitis (HP:0100658)3.91819552
21B lymphocytopenia (HP:0010976)3.88068461
22Eczematoid dermatitis (HP:0000976)3.87313348
23Abnormality of B cell number (HP:0010975)3.85119786
24Chronic otitis media (HP:0000389)3.75043741
25IgA deficiency (HP:0002720)3.74356048
26Gastrointestinal inflammation (HP:0004386)3.69725022
27Inflammation of the large intestine (HP:0002037)3.66843969
28Papilloma (HP:0012740)3.60317726
29Verrucae (HP:0200043)3.60317726
30Recurrent skin infections (HP:0001581)3.56392890
31Emphysema (HP:0002097)3.54450423
32Abnormality of T cell physiology (HP:0011840)3.44620773
33Abnormality of macrophages (HP:0004311)3.36841713
34Encephalitis (HP:0002383)3.33758523
35Stomatitis (HP:0010280)3.28413989
36Abnormality of T cells (HP:0002843)3.26818711
37Restrictive lung disease (HP:0002091)3.26007236
38IgG deficiency (HP:0004315)3.23448743
39Chronic sinusitis (HP:0011109)3.21947710
40Recurrent gram-negative bacterial infections (HP:0005420)3.15358458
41Recurrent pneumonia (HP:0006532)3.05982350
42Viral hepatitis (HP:0006562)3.03547789
43Recurrent lower respiratory tract infections (HP:0002783)2.88972792
44Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.88111226
45T lymphocytopenia (HP:0005403)2.79818899
46Asplenia (HP:0001746)2.68404596
47Chronic obstructive pulmonary disease (HP:0006510)2.68258430
48Obstructive lung disease (HP:0006536)2.68258430
49Abnormality of T cell number (HP:0011839)2.67831827
50Ventricular fibrillation (HP:0001663)2.66750819
51Osteomyelitis (HP:0002754)2.65273774
52Lymphoma (HP:0002665)2.63609831
53Increased IgE level (HP:0003212)2.54180472
54Abnormality of the fingertips (HP:0001211)2.49520951
55Recurrent otitis media (HP:0000403)2.46448736
56Bronchitis (HP:0012387)2.46093873
57Gastrointestinal infarctions (HP:0005244)2.45546380
58Optic neuritis (HP:0100653)2.41631196
59Retrobulbar optic neuritis (HP:0100654)2.41631196
60Leukopenia (HP:0001882)2.37359887
61Prolonged bleeding time (HP:0003010)2.37245530
62Urticaria (HP:0001025)2.36310539
63Aplasia/Hypoplasia of the spleen (HP:0010451)2.35111291
64Autoimmune thrombocytopenia (HP:0001973)2.34760509
65Basal cell carcinoma (HP:0002671)2.34136644
66Myositis (HP:0100614)2.31309159
67Sepsis (HP:0100806)2.29235158
68Abnormality of the prostate (HP:0008775)2.29007986
69Elevated erythrocyte sedimentation rate (HP:0003565)2.28083221
70Pulmonary infiltrates (HP:0002113)2.26980875
71Hypoplasia of the thymus (HP:0000778)2.26942963
72Abnormality of the peritoneum (HP:0002585)2.21275111
73Orchitis (HP:0100796)2.19919752
74Pustule (HP:0200039)2.15120019
75Spontaneous hematomas (HP:0007420)2.14446018
76Chest pain (HP:0100749)2.11714075
77Gingivitis (HP:0000230)2.09877042
78Degeneration of the lateral corticospinal tracts (HP:0002314)2.03803833
79Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.03803833
80Skin rash (HP:0000988)2.03201303
81Granulocytopenia (HP:0001913)2.02538921
82Increased IgM level (HP:0003496)2.00978138
83Bronchiectasis (HP:0002110)1.95288744
84Chronic diarrhea (HP:0002028)1.94996575
85Birth length less than 3rd percentile (HP:0003561)1.94542974
86Slow saccadic eye movements (HP:0000514)1.91084189
87Hypochromic anemia (HP:0001931)1.88509570
88Abnormality of male internal genitalia (HP:0000022)1.87130810
89Abnormality of the pleura (HP:0002103)1.82807847
90Hemoptysis (HP:0002105)1.82319451
91Arthralgia (HP:0002829)1.81925384
92Hepatitis (HP:0012115)1.79254605
93Neutropenia (HP:0001875)1.76357381
94Albinism (HP:0001022)1.75974516
95Aplasia/Hypoplasia of the thymus (HP:0010515)1.74807734
96Epistaxis (HP:0000421)1.74531578
97Thrombocytosis (HP:0001894)1.73187144
98Keratoconjunctivitis (HP:0001096)1.73023158
99Dysmetric saccades (HP:0000641)1.69855525
100Nasal polyposis (HP:0100582)1.69793973

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.73531249
2MAP4K14.72874617
3BLK4.11158399
4LMTK23.57026392
5PRPF4B2.80604766
6MAP3K102.66842837
7SMG12.55482268
8MAP3K132.37645632
9SYK2.24063011
10BTK2.16018225
11ERN12.03751505
12IRAK41.98387967
13MAP3K141.83616897
14CSF1R1.79966175
15JAK31.75867175
16EEF2K1.72401907
17TYK21.69155052
18IKBKE1.67230258
19CSK1.63075402
20MAPK111.58957875
21LYN1.46468052
22MAP2K31.45198051
23BMPR21.43632082
24GRK61.39214193
25TNK21.38883775
26ICK1.38040287
27HCK1.36839551
28FES1.34843801
29CDK121.31689101
30CDK41.21344674
31ITK1.21236576
32IKBKB1.21233940
33TEC1.19450117
34TRIB31.16100198
35STK41.12861024
36FGR1.11779378
37SIK21.11271085
38STK101.05641442
39PIM11.05574037
40TXK1.02098517
41SGK20.99800022
42LCK0.97689853
43NEK90.94656420
44KIT0.93676879
45JAK10.91234701
46MARK30.90985050
47PBK0.90412983
48PRKCQ0.90210452
49PASK0.86937419
50NLK0.82079124
51TBK10.81620459
52MELK0.81543291
53SGK30.80074690
54MAPK70.78099679
55FGFR40.75266393
56CDC42BPA0.74443472
57ZAP700.73241886
58MAPK120.71825355
59MARK20.68619382
60TESK20.68082508
61PDK10.66797176
62TLK10.66641839
63HIPK20.65419853
64SGK4940.64028554
65SGK2230.64028554
66CHUK0.62066729
67NME20.59105857
68SIK30.57386909
69PRKG20.57228429
70TAOK30.56100814
71KSR20.54978716
72VRK10.54723247
73MAP3K90.53835068
74GRK10.53016715
75LRRK20.51498470
76RPS6KA60.50408791
77PIK3CG0.50075960
78MAP3K80.49246448
79BRD40.46904648
80MATK0.44996004
81RPS6KL10.44294721
82RPS6KC10.44294721
83MAP3K10.43957999
84JAK20.42907793
85TAOK20.41580604
86PDPK10.38699940
87SIK10.38041162
88MAPK150.37211796
89FGFR30.36277475
90VRK20.33930288
91PHKG20.33586630
92PHKG10.33586630
93FYN0.33126946
94RPS6KA50.31974393
95STK110.31517805
96TAOK10.29504626
97STK240.26899952
98EPHB10.26188952
99MAP3K70.25977473
100CAMKK10.25223439

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.54056079
2B cell receptor signaling pathway_Homo sapiens_hsa046623.84170397
3Intestinal immune network for IgA production_Homo sapiens_hsa046723.53183848
4Allograft rejection_Homo sapiens_hsa053303.34785575
5Asthma_Homo sapiens_hsa053103.26135295
6Autoimmune thyroid disease_Homo sapiens_hsa053203.19806444
7Graft-versus-host disease_Homo sapiens_hsa053323.09448818
8Leishmaniasis_Homo sapiens_hsa051402.75694284
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.32532845
10Type I diabetes mellitus_Homo sapiens_hsa049402.30269203
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.13130087
12Staphylococcus aureus infection_Homo sapiens_hsa051502.11749020
13Antigen processing and presentation_Homo sapiens_hsa046121.96747522
14Viral myocarditis_Homo sapiens_hsa054161.96736156
15Systemic lupus erythematosus_Homo sapiens_hsa053221.94542454
16Osteoclast differentiation_Homo sapiens_hsa043801.89379925
17T cell receptor signaling pathway_Homo sapiens_hsa046601.86367436
18Hematopoietic cell lineage_Homo sapiens_hsa046401.76601726
19Tuberculosis_Homo sapiens_hsa051521.69875044
20Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.62664132
21Herpes simplex infection_Homo sapiens_hsa051681.62576694
22Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.59362243
23Toxoplasmosis_Homo sapiens_hsa051451.55128138
24Influenza A_Homo sapiens_hsa051641.47710282
25Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.45183758
26Measles_Homo sapiens_hsa051621.38497998
27Toll-like receptor signaling pathway_Homo sapiens_hsa046201.36139519
28Acute myeloid leukemia_Homo sapiens_hsa052211.32776611
29Folate biosynthesis_Homo sapiens_hsa007901.24319862
30Epstein-Barr virus infection_Homo sapiens_hsa051691.21616976
31Viral carcinogenesis_Homo sapiens_hsa052031.17185717
32Hepatitis B_Homo sapiens_hsa051611.16687202
33Chemokine signaling pathway_Homo sapiens_hsa040621.14987813
34RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.11337888
35Non-small cell lung cancer_Homo sapiens_hsa052231.11070081
36HTLV-I infection_Homo sapiens_hsa051661.05053064
37Rheumatoid arthritis_Homo sapiens_hsa053231.02324014
38Alcoholism_Homo sapiens_hsa050340.96290448
39Jak-STAT signaling pathway_Homo sapiens_hsa046300.96208045
40Apoptosis_Homo sapiens_hsa042100.94727120
41Notch signaling pathway_Homo sapiens_hsa043300.90388428
42Chronic myeloid leukemia_Homo sapiens_hsa052200.84330086
43TNF signaling pathway_Homo sapiens_hsa046680.81835107
44Neurotrophin signaling pathway_Homo sapiens_hsa047220.81469091
45Dorso-ventral axis formation_Homo sapiens_hsa043200.80920003
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.80735709
47Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.76127076
48NOD-like receptor signaling pathway_Homo sapiens_hsa046210.75653698
49Hepatitis C_Homo sapiens_hsa051600.73323365
50Colorectal cancer_Homo sapiens_hsa052100.70416386
51Transcriptional misregulation in cancer_Homo sapiens_hsa052020.70094269
52Platelet activation_Homo sapiens_hsa046110.69951608
53Other glycan degradation_Homo sapiens_hsa005110.69613294
54Malaria_Homo sapiens_hsa051440.69243430
55Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.67750399
56Pancreatic cancer_Homo sapiens_hsa052120.67407887
57AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.65111440
58Renal cell carcinoma_Homo sapiens_hsa052110.64415275
59Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.63499485
60Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63260879
61Phagosome_Homo sapiens_hsa041450.62920100
62Leukocyte transendothelial migration_Homo sapiens_hsa046700.58394194
63MAPK signaling pathway_Homo sapiens_hsa040100.56744025
64Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54568932
65Prostate cancer_Homo sapiens_hsa052150.52286742
66mTOR signaling pathway_Homo sapiens_hsa041500.47989409
67GnRH signaling pathway_Homo sapiens_hsa049120.47818239
68Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47788940
69Base excision repair_Homo sapiens_hsa034100.46938742
70HIF-1 signaling pathway_Homo sapiens_hsa040660.46752961
71FoxO signaling pathway_Homo sapiens_hsa040680.45361735
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.45250557
73Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44756037
74Phosphatidylinositol signaling system_Homo sapiens_hsa040700.43782990
75Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.43569164
76African trypanosomiasis_Homo sapiens_hsa051430.43532619
77Ribosome_Homo sapiens_hsa030100.42153684
78VEGF signaling pathway_Homo sapiens_hsa043700.40253651
79Prolactin signaling pathway_Homo sapiens_hsa049170.36784127
80Homologous recombination_Homo sapiens_hsa034400.36147388
81Endometrial cancer_Homo sapiens_hsa052130.35766127
82Inositol phosphate metabolism_Homo sapiens_hsa005620.34676760
83Legionellosis_Homo sapiens_hsa051340.34078619
84Phospholipase D signaling pathway_Homo sapiens_hsa040720.32753017
85Choline metabolism in cancer_Homo sapiens_hsa052310.29635084
86ABC transporters_Homo sapiens_hsa020100.29459781
87Longevity regulating pathway - mammal_Homo sapiens_hsa042110.27276085
88Insulin resistance_Homo sapiens_hsa049310.27027214
89Shigellosis_Homo sapiens_hsa051310.26053200
90Type II diabetes mellitus_Homo sapiens_hsa049300.24263553
91Non-homologous end-joining_Homo sapiens_hsa034500.22593087
92p53 signaling pathway_Homo sapiens_hsa041150.21697846
93MicroRNAs in cancer_Homo sapiens_hsa052060.21414672
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.20978944
95Pentose phosphate pathway_Homo sapiens_hsa000300.20727313
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.20151809
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.19580395
98Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.18902048
99DNA replication_Homo sapiens_hsa030300.18564802
100Glycosaminoglycan degradation_Homo sapiens_hsa005310.18469422

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »