BTBD6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.91626230
2synaptic vesicle maturation (GO:0016188)5.75971097
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.48233646
4locomotory exploration behavior (GO:0035641)5.13176759
5synaptic vesicle exocytosis (GO:0016079)5.12441081
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.12150219
7regulation of synaptic vesicle exocytosis (GO:2000300)4.84663669
8glutamate secretion (GO:0014047)4.82472125
9synaptic vesicle docking involved in exocytosis (GO:0016081)4.71428150
10vocalization behavior (GO:0071625)4.64198405
11layer formation in cerebral cortex (GO:0021819)4.63426792
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.57008716
13NADH metabolic process (GO:0006734)4.53108216
14regulation of synaptic vesicle transport (GO:1902803)4.47588316
15regulation of glutamate receptor signaling pathway (GO:1900449)4.45859535
16regulation of synapse structural plasticity (GO:0051823)4.42902350
17neurotransmitter secretion (GO:0007269)4.29736285
18sodium ion export (GO:0071436)4.27443789
19muscle filament sliding (GO:0030049)4.23370663
20actin-myosin filament sliding (GO:0033275)4.23370663
21sarcoplasmic reticulum calcium ion transport (GO:0070296)4.15733818
22negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.12247928
23cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.07584991
24regulation of neuronal synaptic plasticity (GO:0048168)4.03020855
25neuronal action potential propagation (GO:0019227)3.98696427
26cellular potassium ion homeostasis (GO:0030007)3.95638867
27skeletal muscle contraction (GO:0003009)3.95471077
28activation of protein kinase A activity (GO:0034199)3.95261506
29regulation of long-term neuronal synaptic plasticity (GO:0048169)3.91589371
30exploration behavior (GO:0035640)3.90054614
31regulation of early endosome to late endosome transport (GO:2000641)3.86157628
32ionotropic glutamate receptor signaling pathway (GO:0035235)3.83691836
33gamma-aminobutyric acid transport (GO:0015812)3.83192611
34cell communication by electrical coupling (GO:0010644)3.78858793
35protein localization to synapse (GO:0035418)3.73621228
36membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.70025216
37adherens junction assembly (GO:0034333)3.66502586
38regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.65989054
39focal adhesion assembly (GO:0048041)3.65978522
40cell-substrate adherens junction assembly (GO:0007045)3.65978522
41regulation of ARF protein signal transduction (GO:0032012)3.64367174
42positive regulation of synapse maturation (GO:0090129)3.63631612
43negative regulation of cell size (GO:0045792)3.63538034
44positive regulation of membrane potential (GO:0045838)3.62101539
45barbed-end actin filament capping (GO:0051016)3.56799311
46neuromuscular process controlling posture (GO:0050884)3.55671779
47dendritic spine morphogenesis (GO:0060997)3.54568402
48G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.53197402
49positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.51026917
50actin-mediated cell contraction (GO:0070252)3.48036489
51proline transport (GO:0015824)3.46986533
52prepulse inhibition (GO:0060134)3.46738596
53synaptic transmission, glutamatergic (GO:0035249)3.46713941
54long-term memory (GO:0007616)3.45646305
55regulation of dendritic spine morphogenesis (GO:0061001)3.44931361
56neurotransmitter-gated ion channel clustering (GO:0072578)3.43946308
57low-density lipoprotein particle clearance (GO:0034383)3.40703850
58neuron cell-cell adhesion (GO:0007158)3.38734250
59creatine metabolic process (GO:0006600)3.37706053
60synaptic vesicle endocytosis (GO:0048488)3.36683323
61regulation of excitatory postsynaptic membrane potential (GO:0060079)3.32165539
62positive regulation of receptor recycling (GO:0001921)3.31297036
63positive regulation of synaptic transmission, GABAergic (GO:0032230)3.30158885
64neurotransmitter transport (GO:0006836)3.28585903
65neuron-neuron synaptic transmission (GO:0007270)3.24831742
66protein localization to endosome (GO:0036010)3.24571733
67glutamate receptor signaling pathway (GO:0007215)3.22011028
68cell-substrate junction assembly (GO:0007044)3.20945783
69negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.18150944
70cerebellar Purkinje cell layer development (GO:0021680)3.15994201
71negative regulation of microtubule polymerization (GO:0031115)3.15738041
72regulation of neurotransmitter levels (GO:0001505)3.15267908
73regulation of synaptic plasticity (GO:0048167)3.14415050
74neuromuscular process controlling balance (GO:0050885)3.13610934
75regulation of postsynaptic membrane potential (GO:0060078)3.13543620
76stress fiber assembly (GO:0043149)3.11625617
77dopamine receptor signaling pathway (GO:0007212)3.10827859
78positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.08268312
79positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.07653909
80regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.07069491
81adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.06484890
82cerebellar Purkinje cell differentiation (GO:0021702)3.06438895
83positive regulation of dendritic spine morphogenesis (GO:0061003)3.05224956
84positive regulation of protein dephosphorylation (GO:0035307)3.04600780
85detection of calcium ion (GO:0005513)3.03696045
86cytoskeletal anchoring at plasma membrane (GO:0007016)3.02022993
87skeletal muscle fiber development (GO:0048741)2.99287353
88glycogen catabolic process (GO:0005980)2.98860405
89cell communication involved in cardiac conduction (GO:0086065)2.96767181
90signal complex assembly (GO:0007172)2.95786498
91regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.95774240
92mating behavior (GO:0007617)2.94531375
93positive regulation of myotube differentiation (GO:0010831)2.93382856
94positive regulation of dendritic spine development (GO:0060999)2.92741405
95membrane depolarization during action potential (GO:0086010)2.92040227
96negative regulation of homotypic cell-cell adhesion (GO:0034111)2.91361784
97glycine transport (GO:0015816)2.89841729
98regulation of skeletal muscle contraction (GO:0014819)2.89223155
99striated muscle contraction (GO:0006941)2.89137263
100regulation of vesicle fusion (GO:0031338)2.88870737
101cellular sodium ion homeostasis (GO:0006883)2.88698947
102actin filament-based movement (GO:0030048)2.86062011
103dendrite morphogenesis (GO:0048813)2.84907209
104glucan catabolic process (GO:0009251)2.82884178
105apoptotic process involved in morphogenesis (GO:0060561)2.82058198
106regulation of synaptic transmission, glutamatergic (GO:0051966)2.81993391
107intraspecies interaction between organisms (GO:0051703)2.81549702
108social behavior (GO:0035176)2.81549702
109neuron recognition (GO:0008038)2.80159713
110protein targeting to plasma membrane (GO:0072661)2.79807752
111vesicle transport along microtubule (GO:0047496)2.75998619
112membrane repolarization (GO:0086009)2.75724149
113dendritic spine organization (GO:0097061)2.75334059
114membrane depolarization (GO:0051899)2.74917888
115potassium ion import (GO:0010107)2.74914765
116regulation of dendritic spine development (GO:0060998)2.74203124
117positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.74032281
118endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.73590932
119negative regulation of erythrocyte differentiation (GO:0045647)2.73399400
120triglyceride catabolic process (GO:0019433)2.73270107
121basement membrane organization (GO:0071711)2.72803387
122regulation of neurotransmitter secretion (GO:0046928)2.71923515
123membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.71211990
124positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.70380674
125organelle transport along microtubule (GO:0072384)2.69681808
126regulation of ion transmembrane transporter activity (GO:0032412)2.69454919
127regulation of sequestering of triglyceride (GO:0010889)2.69142653
128positive regulation of neurotransmitter secretion (GO:0001956)2.68912807
129positive regulation of potassium ion transmembrane transport (GO:1901381)2.68461108
130long-term synaptic potentiation (GO:0060291)2.68423962
131maternal placenta development (GO:0001893)2.68210533
132gluconeogenesis (GO:0006094)2.66950081
133regulation of sodium ion transmembrane transporter activity (GO:2000649)2.66656162
134response to pheromone (GO:0019236)2.66257211
135CDP-diacylglycerol metabolic process (GO:0046341)2.65625619
136negative regulation of fatty acid transport (GO:2000192)2.64968782
137innervation (GO:0060384)2.64352936
138membrane hyperpolarization (GO:0060081)2.64010726
139regulation of calcium ion-dependent exocytosis (GO:0017158)2.63742390
140regulation of calcium ion transmembrane transporter activity (GO:1901019)2.63400836
141regulation of calcium ion transmembrane transport (GO:1903169)2.63400836
142negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.62689110
143plasma membrane repair (GO:0001778)2.62217674
144striatum development (GO:0021756)2.61634997
145retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.60646666
146vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.60375921
147regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.60332059
148cellular polysaccharide catabolic process (GO:0044247)2.58099403
149skeletal muscle adaptation (GO:0043501)2.57939195
150cellular response to epinephrine stimulus (GO:0071872)2.57256049
151acylglycerol catabolic process (GO:0046464)2.56424890
152neutral lipid catabolic process (GO:0046461)2.56424890
153cellular response to nutrient (GO:0031670)2.54925199
154glucan biosynthetic process (GO:0009250)2.54681208
155glycogen biosynthetic process (GO:0005978)2.54681208
156cardiac muscle contraction (GO:0060048)2.54143908
157regulation of glucose import in response to insulin stimulus (GO:2001273)2.52753293
158syncytium formation by plasma membrane fusion (GO:0000768)2.50828416
159response to parathyroid hormone (GO:0071107)2.50142497
160myofibril assembly (GO:0030239)2.47078628
161protein retention in ER lumen (GO:0006621)2.45861305
162sarcomere organization (GO:0045214)2.45320803
163cellular response to monoamine stimulus (GO:0071868)2.45035460
164cellular response to catecholamine stimulus (GO:0071870)2.45035460
165myoblast fusion (GO:0007520)2.43026023
166hexose biosynthetic process (GO:0019319)2.41335772
167negative regulation of necroptotic process (GO:0060546)2.40975515
168regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.40897008
169regulation of necrotic cell death (GO:0010939)2.39516482
170regulation of glycogen (starch) synthase activity (GO:2000465)2.38170424
171fatty acid homeostasis (GO:0055089)2.36683378
172regulation of protein dephosphorylation (GO:0035304)2.36372299
173regulation of receptor recycling (GO:0001919)2.35846740
174adhesion of symbiont to host cell (GO:0044650)2.35806753
175virion attachment to host cell (GO:0019062)2.35806753
176positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.34696855
177fructose metabolic process (GO:0006000)2.34129652
178positive regulation of blood vessel endothelial cell migration (GO:0043536)2.33081631
179muscle contraction (GO:0006936)2.31303452
180insulin-like growth factor receptor signaling pathway (GO:0048009)2.30867301
181response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.30643516
182regulation of fatty acid beta-oxidation (GO:0031998)2.30557645
183glycogen metabolic process (GO:0005977)2.30138451
184myotube cell development (GO:0014904)2.29170144
185regulation of mammary gland epithelial cell proliferation (GO:0033599)2.27509954
186metanephric nephron epithelium development (GO:0072243)2.26970894
187polysaccharide catabolic process (GO:0000272)2.26361769
188cellular glucan metabolic process (GO:0006073)2.26224678
189glucan metabolic process (GO:0044042)2.26224678
190actin filament depolymerization (GO:0030042)2.25743235
191negative regulation of peptidyl-serine phosphorylation (GO:0033137)2.25188782
192response to muscle activity (GO:0014850)2.22524547
193epithelial cell-cell adhesion (GO:0090136)2.21967399
194COPI coating of Golgi vesicle (GO:0048205)2.21522976
195Golgi transport vesicle coating (GO:0048200)2.21522976

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.29063322
2RARB_27405468_Chip-Seq_BRAIN_Mouse3.61887409
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.18462269
4RARG_19884340_ChIP-ChIP_MEFs_Mouse3.17242263
5REST_21632747_ChIP-Seq_MESCs_Mouse3.08408144
6DROSHA_22980978_ChIP-Seq_HELA_Human3.04194576
7EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.88062349
8REST_18959480_ChIP-ChIP_MESCs_Mouse2.81521524
9MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.76080659
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.68394867
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.68298290
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.62927972
13NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.56607567
14CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.49752902
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.48411990
16JARID2_20064375_ChIP-Seq_MESCs_Mouse2.46509250
17ELK3_25401928_ChIP-Seq_HUVEC_Human2.39766886
18* ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.38089363
19JARID2_20075857_ChIP-Seq_MESCs_Mouse2.35223298
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.35106561
21RNF2_18974828_ChIP-Seq_MESCs_Mouse2.25939101
22EZH2_18974828_ChIP-Seq_MESCs_Mouse2.25939101
23TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.22242916
24DNAJC2_21179169_ChIP-ChIP_NT2_Human2.19922988
25VDR_21846776_ChIP-Seq_THP-1_Human2.19676964
26IKZF1_21737484_ChIP-ChIP_HCT116_Human2.16260171
27TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.15532220
28SUZ12_27294783_Chip-Seq_ESCs_Mouse2.13207340
29EZH2_27294783_Chip-Seq_ESCs_Mouse2.12607860
30CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.05930517
31ERG_21242973_ChIP-ChIP_JURKAT_Human2.05819650
32ZFP281_18757296_ChIP-ChIP_E14_Mouse2.05608618
33SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.01619963
34SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.01616568
35* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.97412202
36NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.95539837
37SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.89635012
38TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.85790891
39EZH2_27304074_Chip-Seq_ESCs_Mouse1.85336145
40GBX2_23144817_ChIP-Seq_PC3_Human1.84138918
41PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.81302900
42LXR_22292898_ChIP-Seq_THP-1_Human1.80681295
43KDM2B_26808549_Chip-Seq_K562_Human1.79894552
44ZNF263_19887448_ChIP-Seq_K562_Human1.77752923
45RNF2_27304074_Chip-Seq_ESCs_Mouse1.75899774
46RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.69746661
47RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.69565314
48UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.68385922
49NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.66830472
50KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.65957667
51TRIM28_21343339_ChIP-Seq_HEK293_Human1.64527850
52THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.64116424
53CTCF_27219007_Chip-Seq_ERYTHROID_Human1.61148520
54* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.59972717
55KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.59621797
56TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.59283852
57KDM2B_26808549_Chip-Seq_DND41_Human1.59157377
58SRY_22984422_ChIP-ChIP_TESTIS_Rat1.54448268
59ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.52763203
60GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.51127380
61P300_27058665_Chip-Seq_ZR-75-30cells_Human1.49362730
62WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.47395551
63CLOCK_20551151_ChIP-Seq_293T_Human1.44132082
64CREB1_26743006_Chip-Seq_LNCaP_Human1.39137460
65CTCF_27219007_Chip-Seq_Bcells_Human1.38917947
66TBX20_22080862_ChIP-Seq_HEART_Mouse1.38697317
67TBX20_22328084_ChIP-Seq_HEART_Mouse1.38697317
68DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.36262817
69EED_16625203_ChIP-ChIP_MESCs_Mouse1.35191504
70NR3C1_23031785_ChIP-Seq_PC12_Mouse1.33650522
71TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.32922890
72GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.32143485
73TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.31183991
74ZNF274_21170338_ChIP-Seq_K562_Hela1.30501741
75RING1B_27294783_Chip-Seq_ESCs_Mouse1.28150507
76KDM2B_26808549_Chip-Seq_JURKAT_Human1.25991198
77SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.24228359
78TET1_21490601_ChIP-Seq_MESCs_Mouse1.23856864
79ZFP281_27345836_Chip-Seq_ESCs_Mouse1.22973286
80SMC4_20622854_ChIP-Seq_HELA_Human1.21497584
81NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.20436031
82AR_19668381_ChIP-Seq_PC3_Human1.19808367
83RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.18168198
84ATF3_27146783_Chip-Seq_COLON_Human1.18037223
85RXR_22158963_ChIP-Seq_LIVER_Mouse1.17517020
86PPARA_22158963_ChIP-Seq_LIVER_Mouse1.17307841
87WT1_25993318_ChIP-Seq_PODOCYTE_Human1.16549508
88DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.16072426
89TP63_22573176_ChIP-Seq_HFKS_Human1.15374493
90KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.14668614
91* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.14108153
92ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.13797580
93VDR_24763502_ChIP-Seq_THP-1_Human1.13692396
94SA1_27219007_Chip-Seq_Bcells_Human1.13331519
95* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.12699773
96PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11370271
97SMC3_22415368_ChIP-Seq_MEFs_Mouse1.10877699
98SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.10024933
99BCOR_27268052_Chip-Seq_Bcells_Human1.09624806
100SOX2_21211035_ChIP-Seq_LN229_Gbm1.08566513
101KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.06539662
102UBF1/2_26484160_Chip-Seq_HMECs_Human1.06232981
103OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.05977321
104CTCF_26484167_Chip-Seq_Bcells_Mouse1.05604526
105* RUNX1_27514584_Chip-Seq_MCF-7_Human1.05225122
106P63_26484246_Chip-Seq_KERATINOCYTES_Human1.05058103
107TP53_20018659_ChIP-ChIP_R1E_Mouse1.03696723
108NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.03474635
109ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.03382419
110P68_20966046_ChIP-Seq_HELA_Human1.03134869
111TP53_22127205_ChIP-Seq_IMR90_Human1.02616661
112SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.02245294
113MAF_26560356_Chip-Seq_TH2_Human1.01736759
114ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.01378395
115TCF7_22412390_ChIP-Seq_EML_Mouse1.01040804
116MYC_22102868_ChIP-Seq_BL_Human1.00985138
117ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.00692813
118BCL6_27268052_Chip-Seq_Bcells_Human1.00664033
119TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00097593
120STAT6_21828071_ChIP-Seq_BEAS2B_Human1.00096786
121STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.99561524
122FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.99509568
123NFIB_24661679_ChIP-Seq_LUNG_Mouse0.99449774
124CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.99069305
125CTCF_21964334_ChIP-Seq_BJAB-B_Human0.98568740
126PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.98301189
127ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97927303
128GATA1_19941827_ChIP-Seq_MEL_Mouse0.97864179
129SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.96647557
130KLF4_19829295_ChIP-Seq_ESCs_Human0.95652200
131JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.95501662
132MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.94470106
133ESR2_21235772_ChIP-Seq_MCF-7_Human0.93880495
134SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.93310653
135TET1_21451524_ChIP-Seq_MESCs_Mouse0.92455900
136CTBP1_25329375_ChIP-Seq_LNCAP_Human0.91476261
137CTBP2_25329375_ChIP-Seq_LNCAP_Human0.89646080
138SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.89207406
139RING1B_27294783_Chip-Seq_NPCs_Mouse0.87569702
140SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.87412425
141RACK7_27058665_Chip-Seq_MCF-7_Human0.86239617
142SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.85978248
143TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.85104406
144SMAD4_21741376_ChIP-Seq_HESCs_Human0.83491406
145SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83409398
146OCT4_19829295_ChIP-Seq_ESCs_Human0.81620837
147PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.81555009
148SMAD4_21741376_ChIP-Seq_ESCs_Human0.81438538
149CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.80685965
150SMAD4_21799915_ChIP-Seq_A2780_Human0.79541108
151SA1_27219007_Chip-Seq_ERYTHROID_Human0.79055522
152AR_21572438_ChIP-Seq_LNCaP_Human0.78494366
153ELF1_20517297_ChIP-Seq_JURKAT_Human0.78031550

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.31868095
2MP0003705_abnormal_hypodermis_morpholog4.80908355
3MP0003635_abnormal_synaptic_transmissio3.94769408
4MP0003880_abnormal_central_pattern3.91577957
5MP0002822_catalepsy3.50788388
6MP0004270_analgesia3.50387386
7MP0004185_abnormal_adipocyte_glucose3.29797000
8MP0000749_muscle_degeneration3.03389695
9MP0002063_abnormal_learning/memory/cond2.99563804
10MP0005666_abnormal_adipose_tissue2.95470331
11MP0009745_abnormal_behavioral_response2.83770013
12MP0002909_abnormal_adrenal_gland2.81756557
13MP0005670_abnormal_white_adipose2.75175610
14MP0002064_seizures2.71558625
15MP0005451_abnormal_body_composition2.66314845
16MP0005423_abnormal_somatic_nervous2.58380852
17MP0005058_abnormal_lysosome_morphology2.53813381
18MP0005375_adipose_tissue_phenotype2.50747833
19MP0000759_abnormal_skeletal_muscle2.46569698
20MP0008438_abnormal_cutaneous_collagen2.46373920
21MP0002572_abnormal_emotion/affect_behav2.31162366
22MP0001968_abnormal_touch/_nociception2.29099188
23MP0003329_amyloid_beta_deposits2.26386662
24MP0009840_abnormal_foam_cell2.23329793
25MP0002877_abnormal_melanocyte_morpholog2.16619681
26MP0003191_abnormal_cellular_cholesterol2.08683059
27MP0002734_abnormal_mechanical_nocicepti2.07123526
28MP0002837_dystrophic_cardiac_calcinosis2.06533898
29MP0004087_abnormal_muscle_fiber2.06473881
30MP0002272_abnormal_nervous_system2.04798212
31MP0002971_abnormal_brown_adipose2.03946303
32MP0000733_abnormal_muscle_development2.01986666
33MP0009046_muscle_twitch2.00248168
34MP0008961_abnormal_basal_metabolism1.97536112
35MP0009780_abnormal_chondrocyte_physiolo1.96778066
36MP0002733_abnormal_thermal_nociception1.95363550
37MP0004858_abnormal_nervous_system1.93219091
38MP0003283_abnormal_digestive_organ1.90270585
39MP0008569_lethality_at_weaning1.89328135
40MP0010234_abnormal_vibrissa_follicle1.84499199
41MP0001486_abnormal_startle_reflex1.80634523
42MP0004811_abnormal_neuron_physiology1.77986250
43MP0000013_abnormal_adipose_tissue1.76260258
44MP0000750_abnormal_muscle_regeneration1.72742149
45MP0001501_abnormal_sleep_pattern1.72724057
46MP0002332_abnormal_exercise_endurance1.68339747
47MP0001970_abnormal_pain_threshold1.67869951
48MP0002736_abnormal_nociception_after1.67788619
49MP0002796_impaired_skin_barrier1.63097984
50MP0002735_abnormal_chemical_nociception1.59072882
51MP0001958_emphysema1.58496561
52MP0000751_myopathy1.58262801
53MP0001440_abnormal_grooming_behavior1.56864891
54MP0004924_abnormal_behavior1.56426681
55MP0005386_behavior/neurological_phenoty1.56426681
56MP0002106_abnormal_muscle_physiology1.51688700
57MP0008260_abnormal_autophagy1.49788597
58MP0003279_aneurysm1.49311969
59MP0005623_abnormal_meninges_morphology1.48767751
60MP0002557_abnormal_social/conspecific_i1.48618739
61MP0005275_abnormal_skin_tensile1.48479927
62MP0002234_abnormal_pharynx_morphology1.45041242
63MP0002067_abnormal_sensory_capabilities1.44881108
64MP0003566_abnormal_cell_adhesion1.44035439
65MP0002184_abnormal_innervation1.43562908
66MP0000955_abnormal_spinal_cord1.42045342
67MP0005409_darkened_coat_color1.37114768
68MP0006138_congestive_heart_failure1.36154405
69MP0000569_abnormal_digit_pigmentation1.35876933
70MP0005369_muscle_phenotype1.34634903
71MP0003453_abnormal_keratinocyte_physiol1.33867931
72MP0002139_abnormal_hepatobiliary_system1.33012785
73MP0001849_ear_inflammation1.31685544
74MP0002108_abnormal_muscle_morphology1.31452103
75MP0004233_abnormal_muscle_weight1.29538305
76MP0005330_cardiomyopathy1.28719919
77MP0004145_abnormal_muscle_electrophysio1.27260682
78MP0010030_abnormal_orbit_morphology1.27174925
79MP0003633_abnormal_nervous_system1.25633696
80MP0002066_abnormal_motor_capabilities/c1.25313411
81MP0000604_amyloidosis1.23831217
82MP0003091_abnormal_cell_migration1.21173167
83MP0005620_abnormal_muscle_contractility1.21071260
84MP0003879_abnormal_hair_cell1.20667249
85MP0003828_pulmonary_edema1.19845010
86MP0004043_abnormal_pH_regulation1.17795901
87MP0005646_abnormal_pituitary_gland1.15578452
88MP0001346_abnormal_lacrimal_gland1.14616465
89MP0004215_abnormal_myocardial_fiber1.13963079
90MP0001529_abnormal_vocalization1.13347668
91MP0003787_abnormal_imprinting1.11924573
92MP0006276_abnormal_autonomic_nervous1.11788470
93MP0002249_abnormal_larynx_morphology1.11644861
94MP0008872_abnormal_physiological_respon1.10407829
95MP0003303_peritoneal_inflammation1.10303949
96MP0000778_abnormal_nervous_system1.10232158
97MP0005535_abnormal_body_temperature1.09335832
98MP0002970_abnormal_white_adipose1.09163797
99MP0002882_abnormal_neuron_morphology1.08757249
100MP0005360_urolithiasis1.08664715
101MP0003075_altered_response_to1.07821724
102MP0002069_abnormal_eating/drinking_beha1.07584119
103MP0005076_abnormal_cell_differentiation1.06485262
104MP0003172_abnormal_lysosome_physiology1.05854503
105MP0000678_abnormal_parathyroid_gland1.05741697
106MP0008874_decreased_physiological_sensi1.01378255
107MP0005365_abnormal_bile_salt1.01332211
108MP0001661_extended_life_span1.00876148
109MP0004510_myositis1.00671505
110MP0004085_abnormal_heartbeat1.00547991
111MP0000747_muscle_weakness1.00180716
112MP0001984_abnormal_olfaction0.99915140
113MP0004130_abnormal_muscle_cell0.98568470
114MP0005645_abnormal_hypothalamus_physiol0.98461070
115MP0005501_abnormal_skin_physiology0.97404379
116MP0010630_abnormal_cardiac_muscle0.97185534
117MP0009379_abnormal_foot_pigmentation0.97108825
118MP0002269_muscular_atrophy0.96759099
119MP0002152_abnormal_brain_morphology0.96485939
120MP0005085_abnormal_gallbladder_physiolo0.96400251
121MP0002972_abnormal_cardiac_muscle0.95950500
122MP0001502_abnormal_circadian_rhythm0.95546847
123MP0002060_abnormal_skin_morphology0.95103802
124MP0001348_abnormal_lacrimal_gland0.94599886
125MP0003631_nervous_system_phenotype0.93370371
126MP0004885_abnormal_endolymph0.92952688
127MP0003646_muscle_fatigue0.92751378
128MP0005503_abnormal_tendon_morphology0.92689102
129MP0001765_abnormal_ion_homeostasis0.91121417
130MP0005166_decreased_susceptibility_to0.88949606
131MP0003959_abnormal_lean_body0.86122320
132MP0002896_abnormal_bone_mineralization0.85785759
133MP0006036_abnormal_mitochondrial_physio0.85349341
134MP0002078_abnormal_glucose_homeostasis0.85083552
135MP0003137_abnormal_impulse_conducting0.84145330
136MP0004084_abnormal_cardiac_muscle0.83950501
137MP0005499_abnormal_olfactory_system0.82932814
138MP0005394_taste/olfaction_phenotype0.82932814
139MP0009115_abnormal_fat_cell0.82773577
140MP0005023_abnormal_wound_healing0.81791734
141MP0002229_neurodegeneration0.80586441
142MP0002090_abnormal_vision0.80013880
143MP0005187_abnormal_penis_morphology0.79247409
144MP0005167_abnormal_blood-brain_barrier0.79190927
145MP0001944_abnormal_pancreas_morphology0.79101074
146MP0000343_altered_response_to0.79054791
147MP0000003_abnormal_adipose_tissue0.78443020
148MP0003122_maternal_imprinting0.78123084
149MP0005083_abnormal_biliary_tract0.78087705
150MP0005334_abnormal_fat_pad0.77205270
151MP0000767_abnormal_smooth_muscle0.77195558
152MP0010368_abnormal_lymphatic_system0.77129386
153MP0000858_altered_metastatic_potential0.76932874
154MP0003123_paternal_imprinting0.75959049
155MP0003252_abnormal_bile_duct0.75296791
156MP0005165_increased_susceptibility_to0.73285946
157MP0001905_abnormal_dopamine_level0.70866646
158MP0004272_abnormal_basement_membrane0.70673159
159MP0004036_abnormal_muscle_relaxation0.70656316
160MP0001542_abnormal_bone_strength0.69175581
161MP0001664_abnormal_digestion0.67985996
162MP0001544_abnormal_cardiovascular_syste0.67859251
163MP0005385_cardiovascular_system_phenoty0.67859251
164MP0002693_abnormal_pancreas_physiology0.67719682
165MP0004947_skin_inflammation0.66594788
166MP0000681_abnormal_thyroid_gland0.65781784
167MP0006035_abnormal_mitochondrial_morpho0.65750283
168MP0010329_abnormal_lipoprotein_level0.64724805
169MP0004484_altered_response_of0.64574006
170MP0002998_abnormal_bone_remodeling0.63377036
171MP0005257_abnormal_intraocular_pressure0.63353467
172MP0001666_abnormal_nutrient_absorption0.62924705
173MP0003300_gastrointestinal_ulcer0.62786770
174MP0003953_abnormal_hormone_level0.62672999
175MP0005452_abnormal_adipose_tissue0.61585969
176MP0005595_abnormal_vascular_smooth0.61564836
177MP0010352_gastrointestinal_tract_polyps0.58754807
178MP0000462_abnormal_digestive_system0.58712279

Predicted human phenotypes

RankGene SetZ-score
1Type 1 muscle fiber predominance (HP:0003803)5.56750964
2Muscle fiber inclusion bodies (HP:0100299)5.55832441
3Myokymia (HP:0002411)5.54037516
4Nemaline bodies (HP:0003798)5.50585344
5Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.37861072
6Focal motor seizures (HP:0011153)4.98897154
7Visual hallucinations (HP:0002367)4.83623712
8Focal seizures (HP:0007359)4.27060686
9Abnormality of skeletal muscle fiber size (HP:0012084)4.10790818
10Increased variability in muscle fiber diameter (HP:0003557)4.07256300
11Myopathic facies (HP:0002058)3.79655767
12Distal lower limb muscle weakness (HP:0009053)3.78587196
13Increased connective tissue (HP:0009025)3.70327976
14Atonic seizures (HP:0010819)3.57314805
15Centrally nucleated skeletal muscle fibers (HP:0003687)3.52382304
16Supranuclear gaze palsy (HP:0000605)3.50304503
17Distal lower limb amyotrophy (HP:0008944)3.45884654
18Epileptic encephalopathy (HP:0200134)3.41608175
19Hyporeflexia of lower limbs (HP:0002600)3.41511615
20Bundle branch block (HP:0011710)3.36805778
21Spinal rigidity (HP:0003306)3.33080863
22Abnormality of the lower motor neuron (HP:0002366)3.32872322
23Absence seizures (HP:0002121)3.30081650
24Round ear (HP:0100830)3.29703516
25Action tremor (HP:0002345)3.28321990
26Asymmetric septal hypertrophy (HP:0001670)3.25437879
27Protrusio acetabuli (HP:0003179)3.22059801
28Mildly elevated creatine phosphokinase (HP:0008180)3.16484626
29Papilledema (HP:0001085)3.16078429
30EMG: myopathic abnormalities (HP:0003458)3.15089849
31Muscle fiber splitting (HP:0003555)3.13732658
32Depression (HP:0000716)3.09667225
33Poor eye contact (HP:0000817)3.09163915
34Abnormal social behavior (HP:0012433)3.06646327
35Impaired social interactions (HP:0000735)3.06646327
36Rhabdomyolysis (HP:0003201)3.02155392
37Ulnar deviation of the wrist (HP:0003049)3.01399121
38Distal arthrogryposis (HP:0005684)2.94813452
39Neck muscle weakness (HP:0000467)2.94603644
40Generalized tonic-clonic seizures (HP:0002069)2.93221256
41Ankle clonus (HP:0011448)2.91540842
42Difficulty running (HP:0009046)2.89693033
43Bulbar palsy (HP:0001283)2.87366906
44Pheochromocytoma (HP:0002666)2.87080318
45Dialeptic seizures (HP:0011146)2.86771637
46Postural instability (HP:0002172)2.84328099
47Febrile seizures (HP:0002373)2.81723897
48Premature rupture of membranes (HP:0001788)2.78936927
49Mutism (HP:0002300)2.77173647
50Ketoacidosis (HP:0001993)2.75352629
51Agitation (HP:0000713)2.72405198
52Ventricular fibrillation (HP:0001663)2.71822480
53Anxiety (HP:0000739)2.68111457
54Muscle hypertrophy of the lower extremities (HP:0008968)2.66659654
55Exercise-induced myalgia (HP:0003738)2.65495811
56Exercise-induced muscle cramps (HP:0003710)2.60793860
57Muscle stiffness (HP:0003552)2.59946673
58Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.59349557
59Impaired vibration sensation in the lower limbs (HP:0002166)2.59246135
60Cerebral inclusion bodies (HP:0100314)2.57772594
61Truncal ataxia (HP:0002078)2.57533837
62Lower limb amyotrophy (HP:0007210)2.57465291
63Impaired smooth pursuit (HP:0007772)2.55322644
64EEG with generalized epileptiform discharges (HP:0011198)2.54501839
65Vertebral compression fractures (HP:0002953)2.53300680
66Epileptiform EEG discharges (HP:0011182)2.52533121
67Hypsarrhythmia (HP:0002521)2.51274048
68Urinary urgency (HP:0000012)2.48356267
69Abnormal eating behavior (HP:0100738)2.48012571
70Progressive cerebellar ataxia (HP:0002073)2.47990022
71Difficulty climbing stairs (HP:0003551)2.45627034
72Cerebral aneurysm (HP:0004944)2.45572106
73Axonal loss (HP:0003447)2.44983985
74Slender build (HP:0001533)2.43335817
75Obstructive sleep apnea (HP:0002870)2.42502337
76Thin bony cortex (HP:0002753)2.41962364
77Torticollis (HP:0000473)2.40266050
78Dysmetric saccades (HP:0000641)2.39402959
79Subaortic stenosis (HP:0001682)2.37100496
80Abnormality of the left ventricular outflow tract (HP:0011103)2.37100496
81Ankyloglossia (HP:0010296)2.36715230
82Focal dystonia (HP:0004373)2.36564555
83Neoplasm of the heart (HP:0100544)2.35805225
84Neuroendocrine neoplasm (HP:0100634)2.35304161
85Frequent falls (HP:0002359)2.35064826
86Pointed chin (HP:0000307)2.34034526
87Dysdiadochokinesis (HP:0002075)2.33571290
88Bradykinesia (HP:0002067)2.31063740
89Hemiplegia (HP:0002301)2.30630535
90Stridor (HP:0010307)2.30485074
91Abnormality of the calf musculature (HP:0001430)2.30213145
92Insomnia (HP:0100785)2.29969554
93Acanthosis nigricans (HP:0000956)2.29898803
94Ketosis (HP:0001946)2.29380069
95Rapidly progressive (HP:0003678)2.29019930
96Dysmetria (HP:0001310)2.28784100
97Gout (HP:0001997)2.27707513
98Calf muscle hypertrophy (HP:0008981)2.26337541
99Athetosis (HP:0002305)2.23661196
100Global brain atrophy (HP:0002283)2.22374563
101Calcaneovalgus deformity (HP:0001848)2.21446559
102Intention tremor (HP:0002080)2.20323435
103Status epilepticus (HP:0002133)2.19858550
104Generalized amyotrophy (HP:0003700)2.19384579
105Broad-based gait (HP:0002136)2.19326498
106Hypercortisolism (HP:0001578)2.19325405
107Urinary bladder sphincter dysfunction (HP:0002839)2.19173086
108Neurofibrillary tangles (HP:0002185)2.16800483
109Progressive inability to walk (HP:0002505)2.16139416
110Craniofacial dystonia (HP:0012179)2.13921052
111Hyperparathyroidism (HP:0000843)2.13755552
112Foot dorsiflexor weakness (HP:0009027)2.12572480
113Deep palmar crease (HP:0006191)2.11981980
114Amblyopia (HP:0000646)2.11160463
115Abnormality of ocular smooth pursuit (HP:0000617)2.10932644
116Annular pancreas (HP:0001734)2.10883882
117Amyotrophic lateral sclerosis (HP:0007354)2.09976805
118Excessive salivation (HP:0003781)2.08550314
119Drooling (HP:0002307)2.08550314
120Fragile skin (HP:0001030)2.08022078
121Spastic gait (HP:0002064)2.06609542
122Abnormal atrioventricular conduction (HP:0005150)2.06419027
123Reduced subcutaneous adipose tissue (HP:0003758)2.06231378
124Oligomenorrhea (HP:0000876)2.05323067
125Stereotypic behavior (HP:0000733)2.04558713
126Hyperacusis (HP:0010780)2.03716824
127Abnormality of oral frenula (HP:0000190)2.03332121
128Myoglobinuria (HP:0002913)2.02859774
129Tetraplegia (HP:0002445)2.02440961
130Shallow orbits (HP:0000586)2.01593773
131Short nail (HP:0001799)2.01288009
132Sudden death (HP:0001699)2.00723698
133Mitral regurgitation (HP:0001653)2.00538164
134Long toe (HP:0010511)1.98506971
135Scapular winging (HP:0003691)1.97726589
136Abnormal EKG (HP:0003115)1.95659867
137Abnormality of the Achilles tendon (HP:0005109)1.95603093
138Distal upper limb amyotrophy (HP:0007149)1.95304309
139Upper limb amyotrophy (HP:0009129)1.95304309
140Achilles tendon contracture (HP:0001771)1.94900420
141Megalencephaly (HP:0001355)1.94122382
142Neuronal loss in central nervous system (HP:0002529)1.92189995
143Rimmed vacuoles (HP:0003805)1.91888984
144Ventricular tachycardia (HP:0004756)1.91785727
145Hyperinsulinemic hypoglycemia (HP:0000825)1.91453280
146Abnormality of the foot musculature (HP:0001436)1.91383735
147Aortic aneurysm (HP:0004942)1.91046680
148Rigidity (HP:0002063)1.90847291
149Heart block (HP:0012722)1.90736249
150Hypertriglyceridemia (HP:0002155)1.90092828
151Broad face (HP:0000283)1.89877305
152Deformed tarsal bones (HP:0008119)1.89277245
153Unsteady gait (HP:0002317)1.88805821
154Ankle contracture (HP:0006466)1.86655996
155Atrioventricular block (HP:0001678)1.85500228
156Ulnar bowing (HP:0003031)1.84523771
157Psychosis (HP:0000709)1.84507717
158Resting tremor (HP:0002322)1.83830120
159Neoplasm of the peripheral nervous system (HP:0100007)1.83799016
160Apathy (HP:0000741)1.82410731
161Syncope (HP:0001279)1.82192299
162EMG: neuropathic changes (HP:0003445)1.81861013
163Spinal canal stenosis (HP:0003416)1.81707223
164Decreased circulating renin level (HP:0003351)1.81580773
165Back pain (HP:0003418)1.80732563
166Myotonia (HP:0002486)1.80109829
167Ragged-red muscle fibers (HP:0003200)1.79650520
168Scanning speech (HP:0002168)1.79203896
169Absent phalangeal crease (HP:0006109)1.78915242
170Hyperventilation (HP:0002883)1.76968125
171Limb dystonia (HP:0002451)1.76110216
172Restlessness (HP:0000711)1.75818910
173Growth hormone excess (HP:0000845)1.75361644
174Generalized myoclonic seizures (HP:0002123)1.74685500
175Generalized muscle weakness (HP:0003324)1.71319913
176Atrophic scars (HP:0001075)1.70575732
177Easy fatigability (HP:0003388)1.69940722
178Osteolytic defects of the hand bones (HP:0009699)1.69079788
179Osteolytic defects of the phalanges of the hand (HP:0009771)1.69079788
180Lipoatrophy (HP:0100578)1.67439143
181Progressive muscle weakness (HP:0003323)1.65441434
182Abnormality of the calcaneus (HP:0008364)1.64469790
183Gowers sign (HP:0003391)1.63740026
184Dilated cardiomyopathy (HP:0001644)1.63566476
185Elbow flexion contracture (HP:0002987)1.60809510
186Insulin resistance (HP:0000855)1.59584001
187Wormian bones (HP:0002645)1.58948814
188Abnormal finger flexion creases (HP:0006143)1.57061885

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.43696459
2NTRK33.97607863
3EPHA43.93213298
4TTN3.28057193
5OBSCN2.96601876
6MINK12.80943512
7MARK12.79996288
8DAPK22.69351110
9KSR22.56947427
10SIK12.35556575
11IRAK32.35337391
12MAP3K42.28185218
13PRKD32.21703045
14EEF2K2.11365799
15CAMKK12.10848418
16TAOK22.07737146
17PAK61.97494346
18MAP2K31.91048585
19NTRK21.89744125
20MAP2K41.87983007
21TESK11.83327096
22SIK21.80349244
23ERN11.79781808
24MAP2K71.78677316
25NTRK11.78659386
26ARAF1.77957084
27DAPK11.75286813
28KSR11.69923446
29TRIB31.66068660
30SMG11.64337302
31STK381.63222588
32MAP3K131.62818281
33PKN21.61482167
34NME21.59673139
35SCYL21.59589140
36MAPK121.53607281
37ICK1.50507342
38RIPK41.49550981
39MAP3K111.48348049
40MAPKAPK31.43541371
41CDK51.39712355
42RIPK11.30623814
43TAOK11.30301597
44MOS1.25895645
45PHKG21.21529561
46PHKG11.21529561
47FES1.17940092
48UHMK11.15649038
49EPHA21.14010921
50LMTK21.13977151
51MAP3K21.13869325
52CAMKK21.13173951
53NEK11.12021199
54RET1.11311643
55GRK61.08097573
56TNIK1.07296596
57CDK191.06562797
58TYRO31.05542441
59PRKCH1.05082907
60LATS21.04998475
61PRKCG1.01096275
62PRKD20.97821371
63MAPK110.97686317
64MAP3K30.95988069
65ABL20.93103554
66IRAK20.92766442
67MST1R0.90668529
68MAP3K120.89299609
69PDK10.89128633
70ILK0.88887240
71PAK30.85935505
72MAP3K10.84745648
73RAF10.84553440
74MAP3K70.81916717
75GRK50.81665446
76BCKDK0.80583280
77MAPK130.80506357
78DDR20.80349306
79LIMK10.79372581
80STK110.78221725
81EPHB20.77936468
82PRPF4B0.76472986
83CAMK10.74095565
84PDPK10.72557471
85ALK0.72376888
86MTOR0.72073845
87CDK140.71273211
88CDK150.70427741
89CDK180.70209839
90PTK2B0.69946757
91DMPK0.69031606
92PRKG20.67829575
93TBK10.67236708
94CAMK2G0.67156790
95CDK11A0.62942847
96PNCK0.62603736
97PIK3CG0.61746154
98CAMK2A0.61737634
99DAPK30.61403682
100NME10.61395826
101MYLK0.60822200
102PINK10.59668837
103MAP3K60.59175979
104SGK2230.56694525
105SGK4940.56694525
106MAP2K10.56078591
107MARK20.55809237
108LRRK20.55378747
109DYRK1A0.55326560
110SGK30.54227620
111WNK30.53278250
112BMX0.52008454
113MAPK40.51417637
114PRKCZ0.51214830
115AKT20.51054445
116RPS6KA20.50184874
117MAP3K100.49753788
118MUSK0.49392386
119MET0.47985066
120CSNK1G20.47922230
121TGFBR20.47315905
122FER0.47237377
123EPHB10.47148797
124BRAF0.46733293
125SGK10.46593285
126RPS6KA30.45053656
127TRPM70.43072694
128MAP2K60.42416872
129TYK20.42300574
130CAMK2B0.42198245
131PTK20.42195714
132CAMK1D0.41182875
133SGK20.41122261
134CAMK40.40954543
135INSRR0.40839153
136PRKCI0.40707145
137PAK40.40524362
138PRKAA20.39937112
139RPS6KL10.38841162
140RPS6KC10.38841162
141CDC42BPA0.38711965
142MAPK70.37474079
143MAPK100.37333593
144NEK90.37028031
145PLK20.36374907
146FYN0.36362521
147PAK10.36009942
148PIM20.34414422
149PDGFRB0.33954891
150PDGFRA0.33604481
151MAP3K50.33425336
152BRSK10.33385764
153CAMK1G0.33237199
154ZAP700.32566823
155HIPK20.32296842
156PTK60.31455453

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.93061968
2Nicotine addiction_Homo sapiens_hsa050332.69017136
3Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.61494039
4Long-term potentiation_Homo sapiens_hsa047202.59743926
5Amphetamine addiction_Homo sapiens_hsa050312.38040776
6Insulin secretion_Homo sapiens_hsa049112.36182953
7Circadian entrainment_Homo sapiens_hsa047132.30425157
8GABAergic synapse_Homo sapiens_hsa047272.27329757
9Olfactory transduction_Homo sapiens_hsa047402.25085268
10Nitrogen metabolism_Homo sapiens_hsa009102.24719738
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.09673212
12Dopaminergic synapse_Homo sapiens_hsa047282.05460572
13Morphine addiction_Homo sapiens_hsa050322.01733680
14Glutamatergic synapse_Homo sapiens_hsa047242.00137495
15Aldosterone synthesis and secretion_Homo sapiens_hsa049251.85734595
16Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.80881379
17Salivary secretion_Homo sapiens_hsa049701.76474136
18Cocaine addiction_Homo sapiens_hsa050301.75100797
19Cholinergic synapse_Homo sapiens_hsa047251.75078712
20Gastric acid secretion_Homo sapiens_hsa049711.73597615
21Sulfur relay system_Homo sapiens_hsa041221.72133314
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.69952285
23Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.69094265
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.63017294
25Other glycan degradation_Homo sapiens_hsa005111.51608494
26Oxytocin signaling pathway_Homo sapiens_hsa049211.50001701
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.48937244
28Renin secretion_Homo sapiens_hsa049241.47031717
29Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.46007348
30Type II diabetes mellitus_Homo sapiens_hsa049301.44659065
31Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.42661529
32PPAR signaling pathway_Homo sapiens_hsa033201.42495751
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.34904633
34Phenylalanine metabolism_Homo sapiens_hsa003601.33391846
35Taste transduction_Homo sapiens_hsa047421.31345985
36Focal adhesion_Homo sapiens_hsa045101.30707932
37Calcium signaling pathway_Homo sapiens_hsa040201.30246347
38Chronic myeloid leukemia_Homo sapiens_hsa052201.27496756
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.26268821
40Pentose phosphate pathway_Homo sapiens_hsa000301.24044669
41GnRH signaling pathway_Homo sapiens_hsa049121.23921786
42Long-term depression_Homo sapiens_hsa047301.23269107
43Acute myeloid leukemia_Homo sapiens_hsa052211.23180335
44Estrogen signaling pathway_Homo sapiens_hsa049151.22236684
45Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.15581712
46Bladder cancer_Homo sapiens_hsa052191.14165797
47Gap junction_Homo sapiens_hsa045401.13116659
48Cardiac muscle contraction_Homo sapiens_hsa042601.10161959
49Renal cell carcinoma_Homo sapiens_hsa052111.09601450
50Galactose metabolism_Homo sapiens_hsa000521.09178473
51Carbohydrate digestion and absorption_Homo sapiens_hsa049731.08606444
52Glioma_Homo sapiens_hsa052141.08046502
53Notch signaling pathway_Homo sapiens_hsa043301.07780804
54Bile secretion_Homo sapiens_hsa049761.04555072
55Phosphatidylinositol signaling system_Homo sapiens_hsa040701.03847141
56cAMP signaling pathway_Homo sapiens_hsa040241.02419809
57Glucagon signaling pathway_Homo sapiens_hsa049221.01756759
58Arginine biosynthesis_Homo sapiens_hsa002201.01188356
59Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.00467595
60Serotonergic synapse_Homo sapiens_hsa047261.00057753
61AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.99866848
62Glycosaminoglycan degradation_Homo sapiens_hsa005310.98218505
63Vitamin B6 metabolism_Homo sapiens_hsa007500.97799839
64Pancreatic cancer_Homo sapiens_hsa052120.95364933
65cGMP-PKG signaling pathway_Homo sapiens_hsa040220.94140547
66Thyroid hormone synthesis_Homo sapiens_hsa049180.90799814
67Melanogenesis_Homo sapiens_hsa049160.90641163
68Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.90476400
69Butanoate metabolism_Homo sapiens_hsa006500.90293724
70Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.89697245
71Arginine and proline metabolism_Homo sapiens_hsa003300.89200177
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.87789137
73Amoebiasis_Homo sapiens_hsa051460.87222663
74Proteoglycans in cancer_Homo sapiens_hsa052050.86327362
75Pancreatic secretion_Homo sapiens_hsa049720.84373963
76VEGF signaling pathway_Homo sapiens_hsa043700.83457858
77Collecting duct acid secretion_Homo sapiens_hsa049660.82871021
78Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.82361154
79Fatty acid biosynthesis_Homo sapiens_hsa000610.80809151
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.79942245
81B cell receptor signaling pathway_Homo sapiens_hsa046620.79428802
82mTOR signaling pathway_Homo sapiens_hsa041500.77247598
83Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.76009769
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.75861481
85Insulin signaling pathway_Homo sapiens_hsa049100.72910965
86ErbB signaling pathway_Homo sapiens_hsa040120.72755357
87Phospholipase D signaling pathway_Homo sapiens_hsa040720.71084824
88Prion diseases_Homo sapiens_hsa050200.70175462
89Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.70084543
90Dilated cardiomyopathy_Homo sapiens_hsa054140.69422634
91Leukocyte transendothelial migration_Homo sapiens_hsa046700.69395207
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.68779687
93ECM-receptor interaction_Homo sapiens_hsa045120.67662200
94Longevity regulating pathway - mammal_Homo sapiens_hsa042110.66909198
95Glycerolipid metabolism_Homo sapiens_hsa005610.66284664
96Vascular smooth muscle contraction_Homo sapiens_hsa042700.66214517
97Oocyte meiosis_Homo sapiens_hsa041140.65963116
98Vibrio cholerae infection_Homo sapiens_hsa051100.65014126
99Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63633821
100Osteoclast differentiation_Homo sapiens_hsa043800.63484810
101Non-small cell lung cancer_Homo sapiens_hsa052230.63276887
102Regulation of actin cytoskeleton_Homo sapiens_hsa048100.62655929
103Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61312723
104Lysosome_Homo sapiens_hsa041420.61144583
105Prolactin signaling pathway_Homo sapiens_hsa049170.59539516
106Maturity onset diabetes of the young_Homo sapiens_hsa049500.58271798
107Toll-like receptor signaling pathway_Homo sapiens_hsa046200.57806439
108Endometrial cancer_Homo sapiens_hsa052130.56697896
109Hepatitis C_Homo sapiens_hsa051600.56205902
110Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56152624
111Platelet activation_Homo sapiens_hsa046110.53135329
112Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.52795350
113Fructose and mannose metabolism_Homo sapiens_hsa000510.52698590
114FoxO signaling pathway_Homo sapiens_hsa040680.52016394
115Choline metabolism in cancer_Homo sapiens_hsa052310.51520494
116Insulin resistance_Homo sapiens_hsa049310.50939019
117Thyroid cancer_Homo sapiens_hsa052160.49152823
118Endocytosis_Homo sapiens_hsa041440.49134315
119Carbon metabolism_Homo sapiens_hsa012000.48817808
120MAPK signaling pathway_Homo sapiens_hsa040100.48506960
121Pyruvate metabolism_Homo sapiens_hsa006200.47566695
122Biosynthesis of amino acids_Homo sapiens_hsa012300.47030990
123Circadian rhythm_Homo sapiens_hsa047100.46719252
124Axon guidance_Homo sapiens_hsa043600.46663707
125Central carbon metabolism in cancer_Homo sapiens_hsa052300.45089599
126Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.44811796
127Rap1 signaling pathway_Homo sapiens_hsa040150.43769974
128Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43278517
129Alcoholism_Homo sapiens_hsa050340.42673724
130Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.40591413
131Dorso-ventral axis formation_Homo sapiens_hsa043200.40512737
132Cyanoamino acid metabolism_Homo sapiens_hsa004600.40165230
133Inositol phosphate metabolism_Homo sapiens_hsa005620.39792088
134Primary bile acid biosynthesis_Homo sapiens_hsa001200.37188693
135Fatty acid degradation_Homo sapiens_hsa000710.36344097
136Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.35652519
137AMPK signaling pathway_Homo sapiens_hsa041520.34681915
138Adipocytokine signaling pathway_Homo sapiens_hsa049200.34375792
139Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.33762853
140Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33608592

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