BTBD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The C-terminus of the protein encoded by this gene binds topoisomerase I. The N-terminus contains a proline-rich region and a BTB/POZ domain (broad-complex, Tramtrack and bric a brac/Pox virus and Zinc finger), both of which are typically involved in protein-protein interactions. Subcellularly, the protein localizes to cytoplasmic bodies. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of relaxation of muscle (GO:1901077)5.47817596
2actin filament-based movement (GO:0030048)5.25480880
3response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.77033829
4negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.66088078
5cilium or flagellum-dependent cell motility (GO:0001539)4.44112041
6actomyosin structure organization (GO:0031032)4.37883710
7creatine metabolic process (GO:0006600)4.32004477
8negative regulation of potassium ion transmembrane transport (GO:1901380)4.25782430
9skeletal muscle adaptation (GO:0043501)4.21851053
10regulation of actin filament-based movement (GO:1903115)4.21412246
11fusion of sperm to egg plasma membrane (GO:0007342)4.17958124
12positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.07887535
13acrosome assembly (GO:0001675)3.97998948
14tricarboxylic acid cycle (GO:0006099)3.97797320
15plasma membrane repair (GO:0001778)3.91238375
16sperm motility (GO:0030317)3.89624176
17cardiac muscle hypertrophy (GO:0003300)3.84052731
18response to inactivity (GO:0014854)3.80304397
19muscle contraction (GO:0006936)3.80197742
20positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.75356925
21carnitine shuttle (GO:0006853)3.74306736
22layer formation in cerebral cortex (GO:0021819)3.73481719
23response to muscle activity (GO:0014850)3.68118299
24striated muscle hypertrophy (GO:0014897)3.65637409
25cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.65303290
26carnitine transmembrane transport (GO:1902603)3.62132613
27plasma membrane fusion (GO:0045026)3.62023582
28skeletal muscle fiber development (GO:0048741)3.61994327
29synaptic vesicle maturation (GO:0016188)3.60916151
30regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.58293471
31regulation of the force of heart contraction (GO:0002026)3.54258075
32cell wall macromolecule metabolic process (GO:0044036)3.54150855
33cell wall macromolecule catabolic process (GO:0016998)3.54150855
34locomotory exploration behavior (GO:0035641)3.49838430
35carnitine transport (GO:0015879)3.49224508
36amino-acid betaine transport (GO:0015838)3.49224508
37regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.48609741
38NADH metabolic process (GO:0006734)3.47346024
39acrosome reaction (GO:0007340)3.46082535
40sarcoplasmic reticulum calcium ion transport (GO:0070296)3.43439785
41muscle system process (GO:0003012)3.41534422
42striated muscle adaptation (GO:0014888)3.40729639
43regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.40547241
44regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.39415530
45cell communication by electrical coupling (GO:0010644)3.39134880
46regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.36590869
47nuclear pore complex assembly (GO:0051292)3.36443525
48actin-myosin filament sliding (GO:0033275)3.36273005
49muscle filament sliding (GO:0030049)3.36273005
50fatty acid transmembrane transport (GO:1902001)3.35550598
51activation of protein kinase A activity (GO:0034199)3.33272889
52regulation of short-term neuronal synaptic plasticity (GO:0048172)3.29407439
53dicarboxylic acid biosynthetic process (GO:0043650)3.27276663
54regulation of acyl-CoA biosynthetic process (GO:0050812)3.26460745
55glycogen catabolic process (GO:0005980)3.26404925
56myotube cell development (GO:0014904)3.26248330
57positive regulation of myotube differentiation (GO:0010831)3.22803607
58regulation of skeletal muscle cell differentiation (GO:2001014)3.22563082
59regulation of synapse structural plasticity (GO:0051823)3.20453324
60cardiac myofibril assembly (GO:0055003)3.19408090
61striated muscle atrophy (GO:0014891)3.19103540
62sodium ion export (GO:0071436)3.18076870
63regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.18034411
64positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.17318472
65regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.16484126
66muscle hypertrophy (GO:0014896)3.15339714
67negative regulation of inclusion body assembly (GO:0090084)3.12572426
68nuclear pore organization (GO:0006999)3.12241382
69skeletal muscle tissue development (GO:0007519)3.08122045
70regulation of striated muscle contraction (GO:0006942)3.06199022
71regulation of coenzyme metabolic process (GO:0051196)3.04711226
72regulation of cofactor metabolic process (GO:0051193)3.04711226
73sperm-egg recognition (GO:0035036)3.03286532
74focal adhesion assembly (GO:0048041)3.02717771
75cell-substrate adherens junction assembly (GO:0007045)3.02717771
76glucan catabolic process (GO:0009251)3.02188591
77cardiac muscle cell development (GO:0055013)3.00729464
78sarcomere organization (GO:0045214)2.98891327
79cell communication involved in cardiac conduction (GO:0086065)2.96990087
80relaxation of muscle (GO:0090075)2.96726371
81peptidyl-lysine dimethylation (GO:0018027)2.96524712
82cellular protein complex localization (GO:0034629)2.96346061
83cardiac muscle contraction (GO:0060048)2.95258864
84relaxation of cardiac muscle (GO:0055119)2.95029101
85muscle tissue morphogenesis (GO:0060415)2.94179882
86calcium ion-dependent exocytosis (GO:0017156)2.93458930
87succinate metabolic process (GO:0006105)2.93221232
88membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.92806100
89cardiac muscle tissue morphogenesis (GO:0055008)2.92502537
90muscle cell cellular homeostasis (GO:0046716)2.92247895
91cardiac muscle hypertrophy in response to stress (GO:0014898)2.90887080
92muscle hypertrophy in response to stress (GO:0003299)2.90887080
93cardiac muscle adaptation (GO:0014887)2.90887080
94negative regulation of organelle assembly (GO:1902116)2.90829370
95axonemal dynein complex assembly (GO:0070286)2.90824683
96muscle fiber development (GO:0048747)2.89648378
97regulation of membrane repolarization (GO:0060306)2.89563921
98cellular potassium ion homeostasis (GO:0030007)2.88453315
99myofibril assembly (GO:0030239)2.88255475
100regulation of skeletal muscle contraction (GO:0014819)2.86895239
101regulation of calcium ion transmembrane transport (GO:1903169)2.86725681
102regulation of calcium ion transmembrane transporter activity (GO:1901019)2.86725681
103muscle atrophy (GO:0014889)2.86694572
104cellular polysaccharide catabolic process (GO:0044247)2.85074735
105myoblast fusion (GO:0007520)2.84677435
106epithelial cilium movement (GO:0003351)2.84171389
107cardiac cell development (GO:0055006)2.83460919
108multicellular organism reproduction (GO:0032504)2.82939895
109vocalization behavior (GO:0071625)2.82663654
110sperm capacitation (GO:0048240)2.81924644
111positive regulation of cation channel activity (GO:2001259)2.81804203
112positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.81427524
113regulation of cell communication by electrical coupling (GO:0010649)2.81278848
114membrane depolarization during action potential (GO:0086010)2.77535649
115positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.77513837
116synaptic vesicle exocytosis (GO:0016079)2.75474657
117regulation of NFAT protein import into nucleus (GO:0051532)2.75166550
118synaptonemal complex organization (GO:0070193)2.74394938
119striated muscle contraction (GO:0006941)2.74315429
120adherens junction assembly (GO:0034333)2.72561251
121cell-cell recognition (GO:0009988)2.72349223
122COPI coating of Golgi vesicle (GO:0048205)2.71964102
123Golgi transport vesicle coating (GO:0048200)2.71964102
124regulation of sarcomere organization (GO:0060297)2.71264279
125glutamate secretion (GO:0014047)2.71201425
126potassium ion import (GO:0010107)2.70377567
127muscle adaptation (GO:0043500)2.68646699
128actin-mediated cell contraction (GO:0070252)2.67923307
129glycogen biosynthetic process (GO:0005978)2.66829966
130glucan biosynthetic process (GO:0009250)2.66829966
131spermatid development (GO:0007286)2.66368728
132detection of calcium ion (GO:0005513)2.66028002
133regulation of synaptic vesicle exocytosis (GO:2000300)2.65935768
134synaptic vesicle docking involved in exocytosis (GO:0016081)2.65915890
135protein targeting to Golgi (GO:0000042)2.65601766
136exploration behavior (GO:0035640)2.65169226
137cilium movement (GO:0003341)2.63654699
138negative regulation of necroptotic process (GO:0060546)2.63526769
139regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.63373072
140positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.63226357
141binding of sperm to zona pellucida (GO:0007339)2.62076387
142syncytium formation by plasma membrane fusion (GO:0000768)2.61032791
143piRNA metabolic process (GO:0034587)2.60147633
144polysaccharide catabolic process (GO:0000272)2.60130280
145regulation of cAMP-dependent protein kinase activity (GO:2000479)2.58774806
146motile cilium assembly (GO:0044458)2.58683295
147negative regulation of skeletal muscle tissue development (GO:0048642)2.58646707
148endoplasmic reticulum organization (GO:0007029)2.58149066
149regulation of glutamate receptor signaling pathway (GO:1900449)2.58067354
150regulation of potassium ion transmembrane transporter activity (GO:1901016)2.57945740
151regulation of fatty acid oxidation (GO:0046320)2.57713258
152myotube differentiation (GO:0014902)2.57386384
153positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.57208518
154regulation of sulfur metabolic process (GO:0042762)2.57098944
155adult heart development (GO:0007512)2.56598576
156reproduction (GO:0000003)2.54248838
157striated muscle cell development (GO:0055002)2.53451934
158establishment of protein localization to Golgi (GO:0072600)2.53261776
159regulation of potassium ion transmembrane transport (GO:1901379)2.51423283
160membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.50942046
161cellular response to epinephrine stimulus (GO:0071872)2.50070723
162quaternary ammonium group transport (GO:0015697)2.49571638
163regulation of dendritic spine morphogenesis (GO:0061001)2.49213752
164vesicle transport along microtubule (GO:0047496)2.49096265
165skeletal muscle contraction (GO:0003009)2.48106615
166establishment of nucleus localization (GO:0040023)2.47569403
167neurotransmitter secretion (GO:0007269)2.46769809
168epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.46149148

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.08137630
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.18531014
3WT1_19549856_ChIP-ChIP_CCG9911_Human2.53632179
4ZNF274_21170338_ChIP-Seq_K562_Hela2.37569703
5GATA1_22025678_ChIP-Seq_K562_Human2.33420789
6SMAD_19615063_ChIP-ChIP_OVARY_Human2.30552445
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.23347841
8DROSHA_22980978_ChIP-Seq_HELA_Human2.08383300
9RARB_27405468_Chip-Seq_BRAIN_Mouse2.00403728
10CTNNB1_20460455_ChIP-Seq_HCT116_Human1.94725121
11EP300_21415370_ChIP-Seq_HL-1_Mouse1.89610079
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.89309244
13ZNF263_19887448_ChIP-Seq_K562_Human1.87228941
14* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.87213147
15MTF2_20144788_ChIP-Seq_MESCs_Mouse1.82795819
16RBPJ_22232070_ChIP-Seq_NCS_Mouse1.81872651
17REST_21632747_ChIP-Seq_MESCs_Mouse1.80724754
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.79590030
19SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.78986703
20NRF2_20460467_ChIP-Seq_MEFs_Mouse1.78792047
21NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.78792047
22RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.77646796
23TRIM28_21343339_ChIP-Seq_HEK293_Human1.76892801
24SALL4_18804426_ChIP-ChIP_XEN_Mouse1.76638947
25PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.76290500
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.73637318
27GATA4_21415370_ChIP-Seq_HL-1_Mouse1.72820030
28PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.70857442
29SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.70414144
30NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.70330926
31KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.69090640
32MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.68110262
33SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.66598664
34RNF2_18974828_ChIP-Seq_MESCs_Mouse1.64760974
35EZH2_18974828_ChIP-Seq_MESCs_Mouse1.64760974
36CDX2_19796622_ChIP-Seq_MESCs_Mouse1.62695853
37EZH2_27294783_Chip-Seq_ESCs_Mouse1.60942613
38SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.59593874
39Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.56839554
40GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.56369089
41MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.56148773
42SUZ12_27294783_Chip-Seq_ESCs_Mouse1.55727465
43KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.51666700
44* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.51530081
45JARID2_20064375_ChIP-Seq_MESCs_Mouse1.48947999
46CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.47764610
47ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.45055347
48SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.44549481
49PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.44465971
50NFIB_24661679_ChIP-Seq_LUNG_Mouse1.44446176
51SOX9_24532713_ChIP-Seq_HFSC_Mouse1.43827699
52RNF2_27304074_Chip-Seq_ESCs_Mouse1.42264451
53TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.41317570
54REST_18959480_ChIP-ChIP_MESCs_Mouse1.39803584
55CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.39189505
56SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.37168887
57SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.37168887
58MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.36847025
59* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.36844409
60JARID2_20075857_ChIP-Seq_MESCs_Mouse1.35663152
61NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.33970935
62TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33419848
63TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32224618
64SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.32191598
65KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.31608456
66EZH2_27304074_Chip-Seq_ESCs_Mouse1.31541856
67TBX20_22328084_ChIP-Seq_HEART_Mouse1.31312862
68TBX20_22080862_ChIP-Seq_HEART_Mouse1.31312862
69EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.30094664
70RARG_19884340_ChIP-ChIP_MEFs_Mouse1.28288796
71NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.28074142
72* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27309685
73CTBP2_25329375_ChIP-Seq_LNCAP_Human1.26170710
74GBX2_23144817_ChIP-Seq_PC3_Human1.25390324
75BCAT_22108803_ChIP-Seq_LS180_Human1.24908658
76PPAR_26484153_Chip-Seq_NCI-H1993_Human1.24400189
77ESR2_21235772_ChIP-Seq_MCF-7_Human1.23122157
78SMAD4_21799915_ChIP-Seq_A2780_Human1.22908930
79ESR1_20079471_ChIP-ChIP_T-47D_Human1.21981239
80AR_21572438_ChIP-Seq_LNCaP_Human1.21577944
81TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.21042872
82* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.20855294
83MYC_22102868_ChIP-Seq_BL_Human1.20399712
84BRD4_25478319_ChIP-Seq_HGPS_Human1.20261177
85GATA2_21666600_ChIP-Seq_HMVEC_Human1.19807001
86IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.19674694
87CBP_20019798_ChIP-Seq_JUKART_Human1.19674694
88SOX2_21211035_ChIP-Seq_LN229_Gbm1.19285716
89WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.19270318
90WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19195240
91NR3C1_23031785_ChIP-Seq_PC12_Mouse1.17845632
92TCF7_22412390_ChIP-Seq_EML_Mouse1.16069402
93POU3F2_20337985_ChIP-ChIP_501MEL_Human1.13745225
94ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.12972992
95MYB_21317192_ChIP-Seq_ERMYB_Mouse1.12049371
96* AR_21909140_ChIP-Seq_LNCAP_Human1.11326029
97RING1B_27294783_Chip-Seq_ESCs_Mouse1.06385727
98STAT6_21828071_ChIP-Seq_BEAS2B_Human1.06332643
99ELK4_26923725_Chip-Seq_MESODERM_Mouse1.06270930
100* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.05658649
101TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.05638338
102CTBP1_25329375_ChIP-Seq_LNCAP_Human1.05525382
103TCF4_18268006_ChIP-ChIP_LS174T_Human1.04509370
104KDM2B_26808549_Chip-Seq_K562_Human1.04061920
105AR_19668381_ChIP-Seq_PC3_Human1.03542188
106CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.02504128
107FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.01973303
108ZFP281_18757296_ChIP-ChIP_E14_Mouse1.01929224
109NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.01487171
110FOXM1_26456572_ChIP-Seq_MCF-7_Human1.01317567
111ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01175343
112FOXM1_23109430_ChIP-Seq_U2OS_Human1.00340738
113EED_16625203_ChIP-ChIP_MESCs_Mouse1.00182747
114RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.00111039
115EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.99814949
116MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99735620
117KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.99695686
118ARNT_22903824_ChIP-Seq_MCF-7_Human0.99266365
119BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.98533570
120TAF15_26573619_Chip-Seq_HEK293_Human0.98336491
121FOXA2_19822575_ChIP-Seq_HepG2_Human0.97725042
122FLI1_21867929_ChIP-Seq_TH2_Mouse0.97665693
123AR_25329375_ChIP-Seq_VCAP_Human0.97415628
124BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.97178930
125SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96815352
126WDR5_24793694_ChIP-Seq_LNCAP_Human0.96698526
127CJUN_26792858_Chip-Seq_BT549_Human0.96672476
128TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.96669247
129FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.96597175
130GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.96390516
131SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.96326686
132CBX2_27304074_Chip-Seq_ESCs_Mouse0.95950579
133AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.95658086
134TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.95316481
135ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.95296194
136SMAD3_21741376_ChIP-Seq_ESCs_Human0.94849691
137IGF1R_20145208_ChIP-Seq_DFB_Human0.94768968
138THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.94768088
139TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.94282911
140CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.94186317
141PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.93611852
142UBF1/2_26484160_Chip-Seq_HMECs_Human0.93550743
143* SMAD3_21741376_ChIP-Seq_EPCs_Human0.93536370
144ZFX_18555785_ChIP-Seq_MESCs_Mouse0.92515628
145STAT3_23295773_ChIP-Seq_U87_Human0.92486971
146CLOCK_20551151_ChIP-Seq_293T_Human0.91657407
147* SMAD4_21741376_ChIP-Seq_EPCs_Human0.91547714
148YAP1_20516196_ChIP-Seq_MESCs_Mouse0.91159061
149TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.90973145
150ERG_21242973_ChIP-ChIP_JURKAT_Human0.90935991
151NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.90501341
152AHR_22903824_ChIP-Seq_MCF-7_Human0.90424892
153TP53_16413492_ChIP-PET_HCT116_Human0.90064886
154DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.89926546
155* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.89740958
156SOX2_27498859_Chip-Seq_STOMACH_Mouse0.89487415
157* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.89260917
158TOP2B_26459242_ChIP-Seq_MCF-7_Human0.88898801
159SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.88896163
160TCF4_23295773_ChIP-Seq_U87_Human0.88784126
161PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.88592040
162GATA2_19941826_ChIP-Seq_K562_Human0.88380193
163DNAJC2_21179169_ChIP-ChIP_NT2_Human0.88182494
164GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87648712
165SMAD4_21741376_ChIP-Seq_HESCs_Human0.87458972
166TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86859228
167NR3C1_21868756_ChIP-Seq_MCF10A_Human0.86740886
168CHD1_26751641_Chip-Seq_LNCaP_Human0.86671968
169E2F7_22180533_ChIP-Seq_HELA_Human0.85546810
170GATA1_19941826_ChIP-Seq_K562_Human0.84748656
171* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.84270539
172CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.83944120
173GATA1_19941827_ChIP-Seq_MEL86_Mouse0.83633422

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization3.87716898
2MP0000751_myopathy3.77971155
3MP0004859_abnormal_synaptic_plasticity3.77292144
4MP0002837_dystrophic_cardiac_calcinosis3.61743684
5MP0003646_muscle_fatigue3.37347179
6MP0005451_abnormal_body_composition3.20529357
7MP0004145_abnormal_muscle_electrophysio3.11628615
8MP0004130_abnormal_muscle_cell3.06107540
9MP0002877_abnormal_melanocyte_morpholog2.79378610
10MP0004036_abnormal_muscle_relaxation2.79254509
11MP0004084_abnormal_cardiac_muscle2.69397392
12MP0004215_abnormal_myocardial_fiber2.50643878
13MP0004233_abnormal_muscle_weight2.46381528
14MP0000749_muscle_degeneration2.45181234
15MP0009780_abnormal_chondrocyte_physiolo2.38315999
16MP0004270_analgesia2.36448221
17MP0003635_abnormal_synaptic_transmissio2.25637091
18MP0000747_muscle_weakness2.25452387
19MP0004087_abnormal_muscle_fiber2.21662948
20MP0002332_abnormal_exercise_endurance2.21502480
21MP0002009_preneoplasia2.13056663
22MP0005620_abnormal_muscle_contractility1.95725777
23MP0008438_abnormal_cutaneous_collagen1.91151568
24MP0002106_abnormal_muscle_physiology1.89830002
25MP0005330_cardiomyopathy1.86977638
26MP0002909_abnormal_adrenal_gland1.85325898
27MP0000013_abnormal_adipose_tissue1.80810754
28MP0002269_muscular_atrophy1.78478058
29MP0003950_abnormal_plasma_membrane1.77080902
30MP0010352_gastrointestinal_tract_polyps1.75372458
31MP0002063_abnormal_learning/memory/cond1.74514334
32MP0005623_abnormal_meninges_morphology1.74484223
33MP0001661_extended_life_span1.68312806
34MP0000759_abnormal_skeletal_muscle1.64495581
35MP0004484_altered_response_of1.62500229
36MP0009046_muscle_twitch1.60604646
37MP0002822_catalepsy1.60470243
38MP0003880_abnormal_central_pattern1.57869819
39MP0005369_muscle_phenotype1.57742042
40MP0003329_amyloid_beta_deposits1.56813099
41MP0009745_abnormal_behavioral_response1.55011672
42MP0010234_abnormal_vibrissa_follicle1.54299827
43MP0002972_abnormal_cardiac_muscle1.51253032
44MP0005666_abnormal_adipose_tissue1.50736881
45MP0003698_abnormal_male_reproductive1.43362015
46MP0002234_abnormal_pharynx_morphology1.38818910
47MP0008961_abnormal_basal_metabolism1.38606096
48MP0002064_seizures1.36359279
49MP0000750_abnormal_muscle_regeneration1.32891757
50MP0010630_abnormal_cardiac_muscle1.30876141
51MP0005375_adipose_tissue_phenotype1.29780072
52MP0004085_abnormal_heartbeat1.26892871
53MP0003137_abnormal_impulse_conducting1.24698445
54MP0003828_pulmonary_edema1.23033599
55MP0000003_abnormal_adipose_tissue1.22061821
56MP0006138_congestive_heart_failure1.20968814
57MP0005423_abnormal_somatic_nervous1.20780195
58MP0004185_abnormal_adipocyte_glucose1.19452623
59MP0003656_abnormal_erythrocyte_physiolo1.18075320
60MP0008775_abnormal_heart_ventricle1.16999486
61MP0001544_abnormal_cardiovascular_syste1.16751345
62MP0005385_cardiovascular_system_phenoty1.16751345
63MP0002572_abnormal_emotion/affect_behav1.16503094
64MP0003091_abnormal_cell_migration1.16458845
65MP0003045_fibrosis1.15085138
66MP0008569_lethality_at_weaning1.14369857
67MP0001440_abnormal_grooming_behavior1.13501768
68MP0008057_abnormal_DNA_replication1.11676563
69MP0002734_abnormal_mechanical_nocicepti1.11417088
70MP0003705_abnormal_hypodermis_morpholog1.09362721
71MP0005386_behavior/neurological_phenoty1.08818910
72MP0004924_abnormal_behavior1.08818910
73MP0003195_calcinosis1.07384740
74MP0002272_abnormal_nervous_system1.07195025
75MP0002971_abnormal_brown_adipose1.06570496
76MP0002108_abnormal_muscle_morphology1.05860404
77MP0005167_abnormal_blood-brain_barrier1.05770723
78MP0004811_abnormal_neuron_physiology1.05413448
79MP0003566_abnormal_cell_adhesion1.05255576
80MP0004043_abnormal_pH_regulation1.04966291
81MP0005670_abnormal_white_adipose1.02739690
82MP0001486_abnormal_startle_reflex1.02223750
83MP0005187_abnormal_penis_morphology1.01466992
84MP0004858_abnormal_nervous_system1.01347007
85MP0001968_abnormal_touch/_nociception1.00871077
86MP0005535_abnormal_body_temperature0.99331039
87MP0004272_abnormal_basement_membrane0.99283889
88MP0001929_abnormal_gametogenesis0.98270722
89MP0005409_darkened_coat_color0.97979303
90MP0006036_abnormal_mitochondrial_physio0.97908612
91MP0003633_abnormal_nervous_system0.97012228
92MP0002127_abnormal_cardiovascular_syste0.96305096
93MP0005266_abnormal_metabolism0.92019857
94MP0003221_abnormal_cardiomyocyte_apopto0.91364774
95MP0000569_abnormal_digit_pigmentation0.91269862
96MP0002067_abnormal_sensory_capabilities0.86286955
97MP0002896_abnormal_bone_mineralization0.84202959
98MP0000733_abnormal_muscle_development0.83741891
99MP0001984_abnormal_olfaction0.82517704
100MP0000955_abnormal_spinal_cord0.82411124
101MP0000266_abnormal_heart_morphology0.82402552
102MP0000537_abnormal_urethra_morphology0.81866663
103MP0002066_abnormal_motor_capabilities/c0.80679355
104MP0000778_abnormal_nervous_system0.80282224
105MP0002557_abnormal_social/conspecific_i0.78152170
106MP0001765_abnormal_ion_homeostasis0.77678290
107MP0005165_increased_susceptibility_to0.76599702
108MP0002090_abnormal_vision0.76599017
109MP0004885_abnormal_endolymph0.75110298
110MP0004510_myositis0.74625963
111MP0000604_amyloidosis0.73835418
112MP0003879_abnormal_hair_cell0.73643326
113MP0003122_maternal_imprinting0.71784290
114MP0005275_abnormal_skin_tensile0.71231896
115MP0006035_abnormal_mitochondrial_morpho0.69735436
116MP0002078_abnormal_glucose_homeostasis0.69694211
117MP0002733_abnormal_thermal_nociception0.68807951
118MP0002161_abnormal_fertility/fecundity0.68744986
119MP0003631_nervous_system_phenotype0.68111016
120MP0002128_abnormal_blood_circulation0.68069716
121MP0002184_abnormal_innervation0.67415988
122MP0001299_abnormal_eye_distance/0.66033390
123MP0004134_abnormal_chest_morphology0.65971718
124MP0005076_abnormal_cell_differentiation0.59206649
125MP0003385_abnormal_body_wall0.55170501
126MP0001958_emphysema0.54338364
127MP0003300_gastrointestinal_ulcer0.54302616
128MP0001879_abnormal_lymphatic_vessel0.54284779
129MP0003984_embryonic_growth_retardation0.53903734
130MP0009672_abnormal_birth_weight0.52872085
131MP0001730_embryonic_growth_arrest0.51776221
132MP0002166_altered_tumor_susceptibility0.49847480
133MP0002088_abnormal_embryonic_growth/wei0.49421940
134MP0008874_decreased_physiological_sensi0.48828536
135MP0009115_abnormal_fat_cell0.48352153
136MP0005621_abnormal_cell_physiology0.46923224
137MP0001348_abnormal_lacrimal_gland0.46479457
138MP0003690_abnormal_glial_cell0.46281130
139MP0003941_abnormal_skin_development0.46214257
140MP0003634_abnormal_glial_cell0.44901454
141MP0002114_abnormal_axial_skeleton0.44631107
142MP0009697_abnormal_copulation0.44190624
143MP0003279_aneurysm0.44038760
144MP0002925_abnormal_cardiovascular_devel0.43870422
145MP0002086_abnormal_extraembryonic_tissu0.43385240
146MP0000767_abnormal_smooth_muscle0.43260876
147MP0004808_abnormal_hematopoietic_stem0.43193614
148MP0004197_abnormal_fetal_growth/weight/0.42983515
149MP0003959_abnormal_lean_body0.42887677

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)5.39162142
2Exercise-induced muscle cramps (HP:0003710)4.70985405
3Absent/shortened dynein arms (HP:0200106)4.37057691
4Dynein arm defect of respiratory motile cilia (HP:0012255)4.37057691
5Centrally nucleated skeletal muscle fibers (HP:0003687)4.35751339
6Calf muscle hypertrophy (HP:0008981)4.28363051
7Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.28114730
8Muscle hypertrophy of the lower extremities (HP:0008968)4.26621455
9Myoglobinuria (HP:0002913)4.05872017
10Difficulty running (HP:0009046)3.94008438
11Sudden death (HP:0001699)3.85676888
12Muscle fiber inclusion bodies (HP:0100299)3.75754897
13Hyporeflexia of lower limbs (HP:0002600)3.70100280
14Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.54751940
15Type 1 muscle fiber predominance (HP:0003803)3.49202148
16Distal lower limb muscle weakness (HP:0009053)3.39348119
17Distal lower limb amyotrophy (HP:0008944)3.25253413
18Bundle branch block (HP:0011710)3.24162002
19Abnormality of the calf musculature (HP:0001430)3.21513170
20Calcaneovalgus deformity (HP:0001848)3.21415380
21Nemaline bodies (HP:0003798)3.16409064
22Abnormal respiratory motile cilium physiology (HP:0012261)3.06089658
23Muscle fiber splitting (HP:0003555)3.05735383
24Areflexia of lower limbs (HP:0002522)2.78173034
25Deformed tarsal bones (HP:0008119)2.77240397
26Dysmetric saccades (HP:0000641)2.73897365
27Asymmetric septal hypertrophy (HP:0001670)2.73423191
28Visual hallucinations (HP:0002367)2.72153687
29Difficulty climbing stairs (HP:0003551)2.72079126
30Lower limb amyotrophy (HP:0007210)2.69743418
31Scapular winging (HP:0003691)2.67368227
32EMG: myopathic abnormalities (HP:0003458)2.66925749
33Abnormal respiratory epithelium morphology (HP:0012253)2.65388452
34Abnormal respiratory motile cilium morphology (HP:0005938)2.65388452
35Infertility (HP:0000789)2.65170667
36Abnormality of the lower motor neuron (HP:0002366)2.61438029
37Distal arthrogryposis (HP:0005684)2.60880632
38Rhabdomyolysis (HP:0003201)2.59760280
39Increased variability in muscle fiber diameter (HP:0003557)2.59534521
40Rhinitis (HP:0012384)2.58190601
41Myotonia (HP:0002486)2.57752770
42Spinal rigidity (HP:0003306)2.57737664
43Focal motor seizures (HP:0011153)2.54408315
44Absent phalangeal crease (HP:0006109)2.54213434
45Dilated cardiomyopathy (HP:0001644)2.50383437
46Insidious onset (HP:0003587)2.49342193
47Termporal pattern (HP:0011008)2.49342193
48Ventricular fibrillation (HP:0001663)2.48728671
49Urinary urgency (HP:0000012)2.48466349
50Abnormality of the left ventricular outflow tract (HP:0011103)2.39534100
51Subaortic stenosis (HP:0001682)2.39534100
52Muscle stiffness (HP:0003552)2.39233522
53Abnormality of skeletal muscle fiber size (HP:0012084)2.39067918
54Action tremor (HP:0002345)2.37647521
55Abnormality of the calcaneus (HP:0008364)2.36182706
56Abnormality of the foot musculature (HP:0001436)2.35457231
57Abnormal ciliary motility (HP:0012262)2.32642882
58Myokymia (HP:0002411)2.31482870
59Chronic bronchitis (HP:0004469)2.31360277
60Progressive muscle weakness (HP:0003323)2.30230571
61Pheochromocytoma (HP:0002666)2.29042823
62Foot dorsiflexor weakness (HP:0009027)2.28320778
63Impaired vibration sensation in the lower limbs (HP:0002166)2.22091774
64Abnormal finger flexion creases (HP:0006143)2.20542957
65Myopathic facies (HP:0002058)2.17186921
66Generalized muscle weakness (HP:0003324)2.16325432
67Ulnar deviation of the wrist (HP:0003049)2.15020804
68Malignant hyperthermia (HP:0002047)2.14528365
69Increased connective tissue (HP:0009025)2.13821909
70Prolonged QT interval (HP:0001657)2.13035876
71Heart block (HP:0012722)2.12581079
72Round ear (HP:0100830)2.11981434
73Atrial fibrillation (HP:0005110)2.11980795
74Limb-girdle muscle atrophy (HP:0003797)2.11227275
75Focal seizures (HP:0007359)2.09087286
76Ankle clonus (HP:0011448)2.08932066
77Syncope (HP:0001279)2.08175343
78Fetal akinesia sequence (HP:0001989)2.06948541
79Metatarsus adductus (HP:0001840)2.05851473
80Slender build (HP:0001533)2.05466306
81Ventricular tachycardia (HP:0004756)2.04363980
82Primary atrial arrhythmia (HP:0001692)2.03053843
83Urinary bladder sphincter dysfunction (HP:0002839)2.02116965
84Postural instability (HP:0002172)2.00941637
85Frequent falls (HP:0002359)1.99013741
86Shoulder girdle muscle weakness (HP:0003547)1.98242696
87Amyotrophic lateral sclerosis (HP:0007354)1.97733857
88Central scotoma (HP:0000603)1.97406760
89Rimmed vacuoles (HP:0003805)1.96918908
90Ketoacidosis (HP:0001993)1.96080232
91EMG: neuropathic changes (HP:0003445)1.95931703
92Ventricular arrhythmia (HP:0004308)1.95394011
93Depression (HP:0000716)1.93583682
94Dysdiadochokinesis (HP:0002075)1.93183810
95Facial diplegia (HP:0001349)1.91765852
96Hamartoma of the eye (HP:0010568)1.91693918
97Bulbar palsy (HP:0001283)1.91219895
98Neuroendocrine neoplasm (HP:0100634)1.91198720
99Abnormal atrioventricular conduction (HP:0005150)1.91107304
100Achilles tendon contracture (HP:0001771)1.90473446
101Impaired social interactions (HP:0000735)1.87688761
102Abnormal social behavior (HP:0012433)1.87688761
103Gowers sign (HP:0003391)1.87233404
104Nasal polyposis (HP:0100582)1.87066464
105Rapidly progressive (HP:0003678)1.86663764
106Supraventricular tachycardia (HP:0004755)1.86073483
107Supraventricular arrhythmia (HP:0005115)1.84623509
108Resting tremor (HP:0002322)1.83574018
109Cerebral inclusion bodies (HP:0100314)1.82861426
110Atrioventricular block (HP:0001678)1.82183910
111Lipoatrophy (HP:0100578)1.81843875
112Right ventricular cardiomyopathy (HP:0011663)1.80672991
113Poor eye contact (HP:0000817)1.80116524
114Proximal amyotrophy (HP:0007126)1.79980340
115Neoplasm of the peripheral nervous system (HP:0100007)1.79152318
116Abnormality of the Achilles tendon (HP:0005109)1.78744289
117Muscular dystrophy (HP:0003560)1.77763258
118Steppage gait (HP:0003376)1.76328562
119Mildly elevated creatine phosphokinase (HP:0008180)1.75995525
120Papilledema (HP:0001085)1.75768969
121Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.74857441
122Abnormal EKG (HP:0003115)1.74637994
123Limb-girdle muscle weakness (HP:0003325)1.73408598
124Abnormality of the shoulder girdle musculature (HP:0001435)1.72219128
125Gonadotropin excess (HP:0000837)1.71974042
126Conjunctival hamartoma (HP:0100780)1.71631902
127Neck muscle weakness (HP:0000467)1.71377054
128Pelvic girdle muscle weakness (HP:0003749)1.70387893
129Buphthalmos (HP:0000557)1.69783613
130Protrusio acetabuli (HP:0003179)1.69612676
131Hyperkalemia (HP:0002153)1.69535102
132Ragged-red muscle fibers (HP:0003200)1.69060549
133Hip contracture (HP:0003273)1.68132473
134Fatigue (HP:0012378)1.67090684
135Abnormality of the hip-girdle musculature (HP:0001445)1.66669348
136Abnormality of the musculature of the pelvis (HP:0001469)1.66669348
137Long clavicles (HP:0000890)1.63500954
138Ulnar deviation of finger (HP:0009465)1.60934169
139Weak cry (HP:0001612)1.60293470
140Breech presentation (HP:0001623)1.54387309
141Arterial tortuosity (HP:0005116)1.52994610
142Progressive external ophthalmoplegia (HP:0000590)1.52645888
143Scanning speech (HP:0002168)1.51584483
144Papillary thyroid carcinoma (HP:0002895)1.50999910
145Abnormality of the tricuspid valve (HP:0001702)1.49614881
146Osteolytic defects of the hand bones (HP:0009699)1.48766481
147Osteolytic defects of the phalanges of the hand (HP:0009771)1.48766481

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK35.11120177
2PDK45.11120177
3PDK23.19461564
4TRIB33.04506308
5PRKD33.00865086
6PKN22.77495310
7OBSCN2.45206567
8TTN2.40541296
9PHKG12.31239952
10PHKG22.31239952
11PIK3CG2.23609963
12NEK92.04703353
13MARK11.98113386
14PRPF4B1.97548793
15TRPM71.93655031
16MAP3K91.93301815
17MAP3K41.91667766
18LMTK21.90655877
19EPHA41.74372996
20LATS11.72656939
21NTRK31.70967122
22KSR21.67826549
23ERBB31.56307170
24MAP2K41.53833900
25TESK11.48984313
26CDK121.46031723
27STK381.45106650
28DMPK1.44628213
29PAK61.44401667
30WNK41.42659449
31PNCK1.40985531
32CAMKK11.38243916
33ICK1.36213216
34TYRO31.34571483
35PTK2B1.33033203
36MAP3K131.30514066
37MINK11.27701647
38PINK11.27473311
39EIF2AK31.24521487
40RIPK11.22826022
41NEK11.20797327
42CAMK1G1.19895242
43DAPK21.16463878
44CCNB11.12984022
45MAP3K21.12778774
46SCYL21.12713204
47PDK11.09773540
48PDGFRA1.08787798
49RET1.08430291
50NTRK21.05100862
51STK391.02737679
52MOS1.00409976
53KSR10.99980833
54MAP2K30.97699122
55MAP3K70.95399856
56NTRK10.91580404
57BRD40.88523346
58CDK50.86997697
59PDPK10.85269829
60MAPKAPK30.84628803
61CDK60.82922360
62MAPK120.80161207
63AKT20.79419631
64PRKAA20.77416927
65IRAK30.77263631
66PAK30.76370478
67MAP3K140.76340905
68WNK10.75927129
69MET0.75208646
70MAPK110.74996956
71MAP2K70.74390780
72STK30.73456631
73FER0.73145061
74CAMK40.71692799
75PRKCH0.70496261
76CAMK2G0.70138948
77LIMK10.69972907
78PTK60.68895170
79MAP3K60.66349108
80MTOR0.65281016
81PIK3CA0.64400869
82MAPK100.63996173
83RAF10.63491977
84TAOK10.62904467
85MAP3K100.60384063
86BMPR20.59362808
87FGFR30.59353313
88CAMK1D0.58822747
89STK110.58557437
90RPS6KB10.58450676
91RPS6KB20.57703922
92STK38L0.56118161
93EEF2K0.56111485
94FGFR20.55987426
95JAK10.55133979
96MST1R0.55043029
97CAMK2B0.54725868
98LATS20.54675273
99CAMKK20.53840042
100PRKAA10.52267906
101ARAF0.52039513
102ILK0.49381710
103SGK30.48724941
104BCKDK0.48716984
105DYRK1B0.48317457
106RIPK40.47517785
107CDK190.45711990
108SIK10.45019870
109ROCK10.44876370
110CAMK2A0.44126123
111PRKD10.43964148
112MAPK70.43677097
113WNK30.41922189
114MAP2K10.41522558
115PAK20.41348057
116PRKCG0.41337316
117SGK10.41065960
118SIK20.41017249
119FGFR10.39586774
120PLK20.39510123
121RPS6KA30.39135771
122SMG10.38539948
123MAPK40.38189455
124AKT30.37613428
125PDGFRB0.37606646
126CDK140.36168955
127CAMK10.35752558
128ALK0.34975005
129SGK2230.34895869
130SGK4940.34895869
131MYLK0.34151526
132UHMK10.33736341
133PRKCZ0.33052828
134BRAF0.31600936
135PBK0.31589676
136NME10.31540813
137MAP2K60.30730129
138CDK150.30699922
139NEK60.30507498
140CAMK2D0.30370746
141MUSK0.30137718
142EIF2AK10.30075026
143EPHB20.29958816
144STK240.29865255
145EIF2AK20.29834000
146ROCK20.28883254
147MAP3K10.28524843
148SGK20.28297701
149DAPK10.27696575
150PRKACG0.27570345
151YES10.26664585
152PTK20.25117438

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.10106583
2Nitrogen metabolism_Homo sapiens_hsa009102.35111283
3Propanoate metabolism_Homo sapiens_hsa006402.33546415
4Cardiac muscle contraction_Homo sapiens_hsa042601.93462548
5Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.91748270
6Circadian rhythm_Homo sapiens_hsa047101.82193514
7Long-term potentiation_Homo sapiens_hsa047201.81010604
8Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.80406477
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.72110028
10Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.67073933
11Pyruvate metabolism_Homo sapiens_hsa006201.65607195
12Glucagon signaling pathway_Homo sapiens_hsa049221.64792191
13Renin secretion_Homo sapiens_hsa049241.61913096
14Gastric acid secretion_Homo sapiens_hsa049711.58402406
15Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.58234550
16Dilated cardiomyopathy_Homo sapiens_hsa054141.58174449
17Circadian entrainment_Homo sapiens_hsa047131.57207331
18Chronic myeloid leukemia_Homo sapiens_hsa052201.56645687
19Amphetamine addiction_Homo sapiens_hsa050311.56613088
20Fatty acid degradation_Homo sapiens_hsa000711.53195656
21Fatty acid biosynthesis_Homo sapiens_hsa000611.50280399
22Olfactory transduction_Homo sapiens_hsa047401.48388310
23Oxytocin signaling pathway_Homo sapiens_hsa049211.45189861
24Fatty acid metabolism_Homo sapiens_hsa012121.43242443
25Synaptic vesicle cycle_Homo sapiens_hsa047211.42851886
26Pentose phosphate pathway_Homo sapiens_hsa000301.41829821
27GABAergic synapse_Homo sapiens_hsa047271.39740623
28Non-small cell lung cancer_Homo sapiens_hsa052231.37419323
29Insulin secretion_Homo sapiens_hsa049111.36748389
30Dopaminergic synapse_Homo sapiens_hsa047281.36172543
31Carbon metabolism_Homo sapiens_hsa012001.35482384
32Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.33880364
33Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.33334876
34Salivary secretion_Homo sapiens_hsa049701.32718961
35Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.31557793
36Aldosterone synthesis and secretion_Homo sapiens_hsa049251.28881858
37Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.28659487
38Pancreatic cancer_Homo sapiens_hsa052121.25620581
39cGMP-PKG signaling pathway_Homo sapiens_hsa040221.24906162
40Glutamatergic synapse_Homo sapiens_hsa047241.24412424
41Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.22855771
42Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.21762480
43Dorso-ventral axis formation_Homo sapiens_hsa043201.21619549
44Morphine addiction_Homo sapiens_hsa050321.20066375
45Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.19691562
46Nicotine addiction_Homo sapiens_hsa050331.18591558
47Adherens junction_Homo sapiens_hsa045201.17218027
48Calcium signaling pathway_Homo sapiens_hsa040201.14932914
49Cholinergic synapse_Homo sapiens_hsa047251.13781851
50Thyroid cancer_Homo sapiens_hsa052161.10893788
51PPAR signaling pathway_Homo sapiens_hsa033201.09871942
52Estrogen signaling pathway_Homo sapiens_hsa049151.07814325
53AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.06887095
54Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.06548698
55Butanoate metabolism_Homo sapiens_hsa006501.02877042
56Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.02158901
57Insulin signaling pathway_Homo sapiens_hsa049101.00631266
58Type II diabetes mellitus_Homo sapiens_hsa049300.96666639
59cAMP signaling pathway_Homo sapiens_hsa040240.95745242
60Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.94885612
61AMPK signaling pathway_Homo sapiens_hsa041520.94215187
62Adipocytokine signaling pathway_Homo sapiens_hsa049200.93999965
63Insulin resistance_Homo sapiens_hsa049310.93512562
64Arginine and proline metabolism_Homo sapiens_hsa003300.92182420
65Carbohydrate digestion and absorption_Homo sapiens_hsa049730.91712463
66Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.90585737
67Glioma_Homo sapiens_hsa052140.90457150
68Proteoglycans in cancer_Homo sapiens_hsa052050.89270142
69Gap junction_Homo sapiens_hsa045400.88238213
70FoxO signaling pathway_Homo sapiens_hsa040680.87277561
71Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.85362796
72Central carbon metabolism in cancer_Homo sapiens_hsa052300.85197303
73Cocaine addiction_Homo sapiens_hsa050300.85129681
74GnRH signaling pathway_Homo sapiens_hsa049120.84456260
75Bile secretion_Homo sapiens_hsa049760.84315456
76Choline metabolism in cancer_Homo sapiens_hsa052310.84080098
77Bladder cancer_Homo sapiens_hsa052190.82766984
78Vascular smooth muscle contraction_Homo sapiens_hsa042700.81857245
79Oocyte meiosis_Homo sapiens_hsa041140.81838442
80VEGF signaling pathway_Homo sapiens_hsa043700.81081074
81Small cell lung cancer_Homo sapiens_hsa052220.80992919
82Fructose and mannose metabolism_Homo sapiens_hsa000510.80500945
83Inositol phosphate metabolism_Homo sapiens_hsa005620.79804212
84Platelet activation_Homo sapiens_hsa046110.79755706
85mTOR signaling pathway_Homo sapiens_hsa041500.78633370
86Long-term depression_Homo sapiens_hsa047300.76318061
87Regulation of actin cytoskeleton_Homo sapiens_hsa048100.72597227
88Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.72539771
89Prolactin signaling pathway_Homo sapiens_hsa049170.72396042
90Acute myeloid leukemia_Homo sapiens_hsa052210.72275718
91Glycerolipid metabolism_Homo sapiens_hsa005610.69879414
92B cell receptor signaling pathway_Homo sapiens_hsa046620.68152685
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68014244
94Pancreatic secretion_Homo sapiens_hsa049720.67346400
95Melanogenesis_Homo sapiens_hsa049160.67150685
96Arginine biosynthesis_Homo sapiens_hsa002200.67138545
97Thyroid hormone synthesis_Homo sapiens_hsa049180.66705450
98Lysine degradation_Homo sapiens_hsa003100.66619306
99Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66226881
100Amoebiasis_Homo sapiens_hsa051460.65733827
101Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65518202
102Colorectal cancer_Homo sapiens_hsa052100.64850497
103MicroRNAs in cancer_Homo sapiens_hsa052060.63453977
104ECM-receptor interaction_Homo sapiens_hsa045120.63244945
105Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.62370980
106Sphingolipid signaling pathway_Homo sapiens_hsa040710.61564003
107Taste transduction_Homo sapiens_hsa047420.60675130
108Tight junction_Homo sapiens_hsa045300.60325214
109Alzheimers disease_Homo sapiens_hsa050100.59894848
110Prostate cancer_Homo sapiens_hsa052150.59473639
111Axon guidance_Homo sapiens_hsa043600.58142368
112Renal cell carcinoma_Homo sapiens_hsa052110.57912584
113Focal adhesion_Homo sapiens_hsa045100.57147392
114Biosynthesis of amino acids_Homo sapiens_hsa012300.56290540
115Phospholipase D signaling pathway_Homo sapiens_hsa040720.55357455
116Leukocyte transendothelial migration_Homo sapiens_hsa046700.54812782
117Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.54783519
118Prion diseases_Homo sapiens_hsa050200.53341495
119Melanoma_Homo sapiens_hsa052180.51270722
120Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.50880740
121Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49852516
122Parkinsons disease_Homo sapiens_hsa050120.48591924
123Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46841683
124ErbB signaling pathway_Homo sapiens_hsa040120.46042629
125Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.45995208
126Starch and sucrose metabolism_Homo sapiens_hsa005000.45461756
127Endocytosis_Homo sapiens_hsa041440.45162930
128Endometrial cancer_Homo sapiens_hsa052130.45069379
129Serotonergic synapse_Homo sapiens_hsa047260.44831790
130Neurotrophin signaling pathway_Homo sapiens_hsa047220.44063222
131Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.43450903
132MAPK signaling pathway_Homo sapiens_hsa040100.41817751
133Huntingtons disease_Homo sapiens_hsa050160.41496880
134Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41149585
135Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.40201152
136HIF-1 signaling pathway_Homo sapiens_hsa040660.39977144
137Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38071242

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