BTAF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a TAF (TATA box-binding protein-associated factor), which associates with TBP (TATA box-binding protein) to form the B-TFIID complex that is required for transcription initiation of genes by RNA polymerase II. This TAF has DNA-dependent ATPase activity, which drives the dissociation of TBP from DNA, freeing the TBP to associate with other TATA boxes or TATA-less promoters. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)7.01515739
2nuclear pore organization (GO:0006999)6.46133405
3pore complex assembly (GO:0046931)5.48424104
4mitotic sister chromatid cohesion (GO:0007064)5.16956875
5positive regulation of gamma-delta T cell activation (GO:0046645)5.02603121
6monoubiquitinated protein deubiquitination (GO:0035520)4.86503536
7cilium or flagellum-dependent cell motility (GO:0001539)4.48545706
8histone H3-K36 demethylation (GO:0070544)4.41951934
9regulation of B cell receptor signaling pathway (GO:0050855)4.37151448
10regulation of histone H3-K27 methylation (GO:0061085)4.34184441
11B cell receptor signaling pathway (GO:0050853)4.32224053
12regulation of RNA export from nucleus (GO:0046831)4.21144626
13regulation of histone H3-K9 methylation (GO:0051570)4.12536730
14mitotic nuclear envelope disassembly (GO:0007077)4.07784279
15pre-miRNA processing (GO:0031054)4.03297918
16negative thymic T cell selection (GO:0045060)3.99998495
17positive regulation of granulocyte differentiation (GO:0030854)3.96961348
18histone H3-K4 trimethylation (GO:0080182)3.95155065
19negative T cell selection (GO:0043383)3.93810528
20membrane disassembly (GO:0030397)3.89651004
21nuclear envelope disassembly (GO:0051081)3.89651004
22negative regulation of histone methylation (GO:0031061)3.76203774
23histone lysine demethylation (GO:0070076)3.74773551
24piRNA metabolic process (GO:0034587)3.74647334
25regulation of centriole replication (GO:0046599)3.74099784
26mitotic chromosome condensation (GO:0007076)3.73524974
27protein localization to kinetochore (GO:0034501)3.72975207
28regulation of gamma-delta T cell activation (GO:0046643)3.66480200
29gene silencing by RNA (GO:0031047)3.65256384
30peptidyl-lysine trimethylation (GO:0018023)3.64704455
31regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.63438293
32protein localization to chromosome, centromeric region (GO:0071459)3.63228870
33regulation of protein polyubiquitination (GO:1902914)3.61068315
34negative regulation of DNA repair (GO:0045738)3.59185121
35positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.58764255
36fusion of sperm to egg plasma membrane (GO:0007342)3.57754202
37histone demethylation (GO:0016577)3.54936166
38regulation of nucleobase-containing compound transport (GO:0032239)3.53499568
39positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.51813795
40positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.51813795
41positive regulation of mitotic sister chromatid separation (GO:1901970)3.51813795
42male meiosis (GO:0007140)3.51548518
43translesion synthesis (GO:0019985)3.45698602
44regulation of gamma-delta T cell differentiation (GO:0045586)3.43361456
45regulation of DNA endoreduplication (GO:0032875)3.43183943
46phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.41690477
47DNA geometric change (GO:0032392)3.41317740
48synaptonemal complex assembly (GO:0007130)3.41212372
49DNA duplex unwinding (GO:0032508)3.40206366
50NLS-bearing protein import into nucleus (GO:0006607)3.37639305
51response to muramyl dipeptide (GO:0032495)3.36270069
52sister chromatid segregation (GO:0000819)3.35303910
53DNA replication-dependent nucleosome assembly (GO:0006335)3.34733251
54DNA replication-dependent nucleosome organization (GO:0034723)3.34733251
55dosage compensation (GO:0007549)3.34121783
56acrosome assembly (GO:0001675)3.31363234
57chromatin assembly (GO:0031497)3.30359787
58sister chromatid cohesion (GO:0007062)3.29652225
59regulation of spindle organization (GO:0090224)3.28287229
60positive regulation of chromosome segregation (GO:0051984)3.28020420
61interkinetic nuclear migration (GO:0022027)3.22732283
62cellular response to ethanol (GO:0071361)3.22211337
63DNA unwinding involved in DNA replication (GO:0006268)3.20687843
64positive regulation of B cell differentiation (GO:0045579)3.19812973
65cytoplasmic mRNA processing body assembly (GO:0033962)3.17537031
66synaptonemal complex organization (GO:0070193)3.16020220
67positive regulation of DNA-templated transcription, initiation (GO:2000144)3.15130481
68meiotic chromosome segregation (GO:0045132)3.15108809
69positive regulation of developmental pigmentation (GO:0048087)3.13354008
70positive T cell selection (GO:0043368)3.12931939
71regulation of sister chromatid cohesion (GO:0007063)3.11239817
72sperm-egg recognition (GO:0035036)3.10880293
73peptidyl-lysine methylation (GO:0018022)3.10640324
74protein dealkylation (GO:0008214)3.09213710
75protein demethylation (GO:0006482)3.09213710
76T cell lineage commitment (GO:0002360)3.08711445
77regulation of centrosome cycle (GO:0046605)3.06954538
78regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.06814658
79positive thymic T cell selection (GO:0045059)3.06579683
80histone H3-K9 modification (GO:0061647)3.06536081
81regulation of alpha-beta T cell proliferation (GO:0046640)3.05616490
82histone H2A monoubiquitination (GO:0035518)3.04150186
83positive regulation of alpha-beta T cell proliferation (GO:0046641)3.03127833
84regulation of mitotic spindle organization (GO:0060236)3.03113710
85folic acid-containing compound biosynthetic process (GO:0009396)3.01763256
86histone H3-K4 methylation (GO:0051568)3.01622544
87RNA stabilization (GO:0043489)3.01143803
88mRNA stabilization (GO:0048255)3.01143803
89nuclear envelope organization (GO:0006998)3.01092710
90definitive hemopoiesis (GO:0060216)2.99273083
91binding of sperm to zona pellucida (GO:0007339)2.98473101
92heterochromatin organization (GO:0070828)2.98255061
93positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.97303715
94regulation of B cell differentiation (GO:0045577)2.96798345
95CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.95490329
96B cell homeostasis (GO:0001782)2.94941609
97cell-cell recognition (GO:0009988)2.94466327
98embryonic process involved in female pregnancy (GO:0060136)2.93324372
99mitotic sister chromatid segregation (GO:0000070)2.92841127
100DNA conformation change (GO:0071103)2.92373972
101chromosome organization involved in meiosis (GO:0070192)2.90487602
102gene silencing (GO:0016458)2.89729344
103T cell selection (GO:0045058)2.89624056
104thymic T cell selection (GO:0045061)2.89604622
105mitotic metaphase plate congression (GO:0007080)2.88258635
106regulation of translational termination (GO:0006449)2.85594808
107B cell proliferation (GO:0042100)2.85100984
108histone lysine methylation (GO:0034968)2.84944501
109T cell migration (GO:0072678)2.83216661
110histone H3-K9 methylation (GO:0051567)2.82666812
111regulation of centrosome duplication (GO:0010824)2.82646716
112chromatin assembly or disassembly (GO:0006333)2.82481912
113DNA packaging (GO:0006323)2.80887062
114response to interleukin-15 (GO:0070672)2.80190806
115regulation of translational fidelity (GO:0006450)2.79744114
116genitalia morphogenesis (GO:0035112)2.79333163
117chromosome condensation (GO:0030261)2.78821315
118metaphase plate congression (GO:0051310)2.74884589
119positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.73426073
120negative regulation of histone modification (GO:0031057)2.73229801
121chaperone-mediated protein complex assembly (GO:0051131)2.72652313
122spindle assembly involved in mitosis (GO:0090307)2.72524672
123positive regulation of protein import into nucleus, translocation (GO:0033160)2.71103738
124regulation of chromosome segregation (GO:0051983)2.70721919
125multicellular organism reproduction (GO:0032504)2.70594457
126protein localization to chromosome (GO:0034502)2.70384543
127positive regulation of interleukin-2 production (GO:0032743)2.70038702
128Peyers patch development (GO:0048541)2.69950559
129mucosal-associated lymphoid tissue development (GO:0048537)2.69950559
130histone mRNA catabolic process (GO:0071044)2.69033506
131histone H4-K16 acetylation (GO:0043984)2.68534327
132negative regulation of erythrocyte differentiation (GO:0045647)2.68466204
133negative regulation of cell killing (GO:0031342)2.68333452
134negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.68333452
135nucleus organization (GO:0006997)2.66884996
136IMP biosynthetic process (GO:0006188)2.66870952
137regulation of histone methylation (GO:0031060)2.66582078
138regulation of granulocyte differentiation (GO:0030852)2.66496803
139mRNA transport (GO:0051028)2.65538475
140histone H3-K9 demethylation (GO:0033169)2.64991558
141kinetochore organization (GO:0051383)2.64049933
142meiotic nuclear division (GO:0007126)2.61613632
143histone exchange (GO:0043486)2.60551822
144attachment of spindle microtubules to kinetochore (GO:0008608)2.60086634
145negative regulation of chromatin modification (GO:1903309)2.60026673
146DNA replication initiation (GO:0006270)2.59820991
147nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.59342113
148DNA topological change (GO:0006265)2.58096987
149response to UV-C (GO:0010225)2.57917291
150cell wall macromolecule catabolic process (GO:0016998)2.57534155
151cell wall macromolecule metabolic process (GO:0044036)2.57534155
152negative regulation of T cell mediated immunity (GO:0002710)2.57507795
153microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.55361494
154regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.54874076
155spliceosomal tri-snRNP complex assembly (GO:0000244)2.54253080
156DNA synthesis involved in DNA repair (GO:0000731)2.53547348
157germinal center formation (GO:0002467)2.53178714
158histone phosphorylation (GO:0016572)2.52987006
159V(D)J recombination (GO:0033151)2.49835214
160mRNA splice site selection (GO:0006376)2.49340616
161regulation of NFAT protein import into nucleus (GO:0051532)2.46874772
162mature B cell differentiation (GO:0002335)2.45687727
163regulation of DNA damage checkpoint (GO:2000001)2.45594796
164positive regulation of histone methylation (GO:0031062)2.43760500
165positive regulation of histone H3-K4 methylation (GO:0051571)2.40635601
166negative regulation of neurotransmitter secretion (GO:0046929)2.37095770
167peptidyl-lysine dimethylation (GO:0018027)2.35997970
168regulation of histone H3-K4 methylation (GO:0051569)2.32977468
169histone methylation (GO:0016571)2.32592462
170regulation of interleukin-2 biosynthetic process (GO:0045076)2.31511427

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.22315734
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.28786526
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.13883176
4EGR1_19374776_ChIP-ChIP_THP-1_Human4.06510664
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.82284988
6SALL1_21062744_ChIP-ChIP_HESCs_Human3.43177782
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.18520951
8* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.93948540
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.76542870
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.70891428
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.41571689
12AR_21909140_ChIP-Seq_LNCAP_Human2.36292089
13E2F1_21310950_ChIP-Seq_MCF-7_Human2.30976053
14RUNX_20019798_ChIP-Seq_JUKART_Human2.23474815
15MYC_22102868_ChIP-Seq_BL_Human2.21775970
16* ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.09369205
17GATA1_22025678_ChIP-Seq_K562_Human2.04611174
18E2F7_22180533_ChIP-Seq_HELA_Human10.1235075
19SMAD_19615063_ChIP-ChIP_OVARY_Human1.87310670
20MYC_18555785_ChIP-Seq_MESCs_Mouse1.82204214
21VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.65276337
22* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.64315487
23* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.59039735
24* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.55053718
25STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.54575361
26MYB_21317192_ChIP-Seq_ERMYB_Mouse1.48797724
27* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.46692041
28RBPJ_22232070_ChIP-Seq_NCS_Mouse1.41750481
29* IRF8_22096565_ChIP-ChIP_GC-B_Human1.38871739
30RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.37985403
31MYB_26560356_Chip-Seq_TH1_Human1.34870697
32MYB_26560356_Chip-Seq_TH2_Human1.33262687
33BRD4_27068464_Chip-Seq_AML-cells_Mouse1.32913266
34TCF7_22412390_ChIP-Seq_EML_Mouse1.30866861
35KDM5A_27292631_Chip-Seq_BREAST_Human1.30508850
36MYC_19079543_ChIP-ChIP_MESCs_Mouse1.30448736
37POU3F2_20337985_ChIP-ChIP_501MEL_Human1.29483091
38MYC_19030024_ChIP-ChIP_MESCs_Mouse1.28486860
39MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.26585297
40NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.22108510
41* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.21971413
42SCL_19346495_ChIP-Seq_HPC-7_Human1.21730469
43FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.21690124
44IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.18646372
45STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.18593178
46WT1_19549856_ChIP-ChIP_CCG9911_Human1.17625952
47SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.17238290
48PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16967246
49* ELK1_19687146_ChIP-ChIP_HELA_Human1.16867715
50STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.15436149
51NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.15370752
52FUS_26573619_Chip-Seq_HEK293_Human1.15072974
53TFEB_21752829_ChIP-Seq_HELA_Human1.14225502
54TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.13149039
55PADI4_21655091_ChIP-ChIP_MCF-7_Human1.10490755
56KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.10177169
57* IRF8_27001747_Chip-Seq_BMDM_Mouse1.09454520
58* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.09157323
59PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.05430054
60HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.05192864
61EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.05177266
62YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04969963
63SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.04377655
64GATA3_26560356_Chip-Seq_TH2_Human1.04356931
65SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.03004526
66PKCTHETA_26484144_Chip-Seq_BREAST_Human1.02818013
67UTX_26944678_Chip-Seq_JUKART_Human1.01589793
68MAF_26560356_Chip-Seq_TH1_Human1.00890974
69NOTCH1_21737748_ChIP-Seq_TLL_Human1.00657134
70MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.99379328
71IRF8_21731497_ChIP-ChIP_J774_Mouse0.98947307
72SALL4_18804426_ChIP-ChIP_XEN_Mouse0.97914351
73VDR_24763502_ChIP-Seq_THP-1_Human0.96283923
74* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.96165065
75SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.96147739
76CIITA_25753668_ChIP-Seq_RAJI_Human0.96126650
77SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.96098361
78MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.96025705
79* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.95841150
80VDR_24787735_ChIP-Seq_THP-1_Human0.93997901
81RUNX1_22412390_ChIP-Seq_EML_Mouse0.93712339
82FLI1_27457419_Chip-Seq_LIVER_Mouse0.93632804
83VDR_23849224_ChIP-Seq_CD4+_Human0.93475832
84E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.93436095
85* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92582542
86IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.92490394
87FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.91537786
88EWS_26573619_Chip-Seq_HEK293_Human0.91468855
89* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.91148039
90TP53_16413492_ChIP-PET_HCT116_Human0.90583159
91KLF4_18555785_ChIP-Seq_MESCs_Mouse0.90457754
92MAF_26560356_Chip-Seq_TH2_Human0.90385791
93STAT3_1855785_ChIP-Seq_MESCs_Mouse0.90123606
94* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.89313041
95PU_27001747_Chip-Seq_BMDM_Mouse0.88585484
96KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.87967229
97SPI1_23127762_ChIP-Seq_K562_Human0.87728230
98* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.86759334
99FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.86707469
100HOXB4_20404135_ChIP-ChIP_EML_Mouse0.86522720
101SPI1_23547873_ChIP-Seq_NB4_Human0.86490800
102POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.86239142
103FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.86017348
104VDR_21846776_ChIP-Seq_THP-1_Human0.85940765
105ERG_20887958_ChIP-Seq_HPC-7_Mouse0.85933619
106BRD4_25478319_ChIP-Seq_HGPS_Human0.85877173
107SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.85724562
108DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.85604654
109STAT4_19710469_ChIP-ChIP_TH1__Mouse0.85009783
110ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.84740384
111* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.84338563
112* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.83957492
113FOXO3_23340844_ChIP-Seq_DLD1_Human0.83414075
114* CHD1_26751641_Chip-Seq_LNCaP_Human0.81843132
115SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.81139155
116SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.81139155
117XRN2_22483619_ChIP-Seq_HELA_Human0.81033674
118SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.80912659
119* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.80804916
120NCOR1_26117541_ChIP-Seq_K562_Human0.80490563
121TAF15_26573619_Chip-Seq_HEK293_Human0.79850312
122KDM2B_26808549_Chip-Seq_JURKAT_Human0.79478593
123CTNNB1_20460455_ChIP-Seq_HCT116_Human0.79332717
124SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.79145288
125ETS1_22383799_ChIP-Seq_G1ME_Mouse0.78470474
126TP63_19390658_ChIP-ChIP_HaCaT_Human0.78355563
127* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.78248897
128SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.77923246
129FOXP3_21729870_ChIP-Seq_TREG_Human0.77753866
130PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.77297085
131GATA3_27048872_Chip-Seq_THYMUS_Human0.76993750

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.62534163
2MP0010094_abnormal_chromosome_stability3.34557289
3MP0000569_abnormal_digit_pigmentation3.30745922
4MP0010352_gastrointestinal_tract_polyps3.20503101
5MP0010307_abnormal_tumor_latency3.16502254
6MP0003111_abnormal_nucleus_morphology3.07827514
7MP0008877_abnormal_DNA_methylation2.80516928
8MP0003693_abnormal_embryo_hatching2.80151809
9MP0003077_abnormal_cell_cycle2.71336184
10MP0005076_abnormal_cell_differentiation2.46868961
11MP0008007_abnormal_cellular_replicative2.37442738
12MP0005410_abnormal_fertilization2.21609064
13MP0010234_abnormal_vibrissa_follicle2.20122779
14MP0008058_abnormal_DNA_repair2.12438768
15MP0004957_abnormal_blastocyst_morpholog2.09091776
16MP0004808_abnormal_hematopoietic_stem2.08767060
17MP0005671_abnormal_response_to2.02738733
18MP0003705_abnormal_hypodermis_morpholog1.94054888
19MP0002396_abnormal_hematopoietic_system1.88500176
20MP0005387_immune_system_phenotype1.84955926
21MP0005000_abnormal_immune_tolerance1.75780108
22MP0005397_hematopoietic_system_phenotyp1.74456732
23MP0001545_abnormal_hematopoietic_system1.74456732
24MP0000350_abnormal_cell_proliferation1.74395886
25MP0003300_gastrointestinal_ulcer1.73830516
26MP0001730_embryonic_growth_arrest1.73553953
27MP0001929_abnormal_gametogenesis1.64157456
28MP0002166_altered_tumor_susceptibility1.58250826
29MP0005380_embryogenesis_phenotype1.52824750
30MP0001672_abnormal_embryogenesis/_devel1.52824750
31MP0002086_abnormal_extraembryonic_tissu1.50507317
32MP0003984_embryonic_growth_retardation1.47849342
33MP0002088_abnormal_embryonic_growth/wei1.47582822
34MP0004197_abnormal_fetal_growth/weight/1.45588203
35MP0003566_abnormal_cell_adhesion1.45176579
36MP0001873_stomach_inflammation1.41702584
37MP0002210_abnormal_sex_determination1.40162602
38MP0009278_abnormal_bone_marrow1.38234329
39MP0002084_abnormal_developmental_patter1.37854965
40MP0003890_abnormal_embryonic-extraembry1.35676292
41MP0003786_premature_aging1.34144803
42MP0001697_abnormal_embryo_size1.32870870
43MP0003123_paternal_imprinting1.28434187
44MP0003763_abnormal_thymus_physiology1.28249795
45MP0002398_abnormal_bone_marrow1.24535804
46MP0002006_tumorigenesis1.22398384
47MP0003698_abnormal_male_reproductive1.21819688
48MP0001835_abnormal_antigen_presentation1.20522121
49MP0001145_abnormal_male_reproductive1.19730621
50MP0002080_prenatal_lethality1.17557167
51MP0004381_abnormal_hair_follicle1.17511659
52MP0003221_abnormal_cardiomyocyte_apopto1.16336998
53MP0003303_peritoneal_inflammation1.15931791
54MP0005310_abnormal_salivary_gland1.14239727
55MP0003091_abnormal_cell_migration1.13055058
56MP0002419_abnormal_innate_immunity1.12851764
57MP0003172_abnormal_lysosome_physiology1.12374327
58MP0002085_abnormal_embryonic_tissue1.12250197
59MP0002019_abnormal_tumor_incidence1.12139739
60MP0000490_abnormal_crypts_of1.11812684
61MP0000703_abnormal_thymus_morphology1.11400501
62MP0010155_abnormal_intestine_physiology1.10129291
63MP0001915_intracranial_hemorrhage1.10063172
64MP0003121_genomic_imprinting1.09683281
65MP0006054_spinal_hemorrhage1.09347658
66MP0000313_abnormal_cell_death1.08203585
67MP0002877_abnormal_melanocyte_morpholog1.07015662
68MP0001800_abnormal_humoral_immune1.06304713
69MP0000653_abnormal_sex_gland1.05923494
70MP0009703_decreased_birth_body1.05921993
71MP0008961_abnormal_basal_metabolism1.04183863
72MP0010678_abnormal_skin_adnexa1.02424605
73MP0001293_anophthalmia1.02023106
74MP0000685_abnormal_immune_system0.99156015
75MP0000733_abnormal_muscle_development0.98168203
76MP0008932_abnormal_embryonic_tissue0.97738551
77MP0000689_abnormal_spleen_morphology0.97261666
78MP0002722_abnormal_immune_system0.97196173
79MP0004947_skin_inflammation0.95058579
80MP0005451_abnormal_body_composition0.94382353
81MP0005025_abnormal_response_to0.93635981
82MP0000465_gastrointestinal_hemorrhage0.93599345
83MP0009697_abnormal_copulation0.93574324
84MP0004264_abnormal_extraembryonic_tissu0.92762355
85MP0002092_abnormal_eye_morphology0.92606987
86MP0004185_abnormal_adipocyte_glucose0.91114457
87MP0005621_abnormal_cell_physiology0.90865141
88MP0005023_abnormal_wound_healing0.90793232
89MP0002452_abnormal_antigen_presenting0.90792621
90MP0001851_eye_inflammation0.89827034
91MP0005220_abnormal_exocrine_pancreas0.88984995
92MP0000427_abnormal_hair_cycle0.88133622
93MP0003453_abnormal_keratinocyte_physiol0.86199494
94MP0000371_diluted_coat_color0.86131492
95MP0002928_abnormal_bile_duct0.85587198
96MP0002009_preneoplasia0.84858343
97MP0003448_altered_tumor_morphology0.84520229
98MP0008438_abnormal_cutaneous_collagen0.84342809
99MP0002429_abnormal_blood_cell0.83580173
100MP0000716_abnormal_immune_system0.83007496
101MP0002405_respiratory_system_inflammati0.82188386
102MP0003828_pulmonary_edema0.80485952
103MP0009672_abnormal_birth_weight0.80045452
104MP0003436_decreased_susceptibility_to0.78998645
105MP0003656_abnormal_erythrocyte_physiolo0.78732427
106MP0001661_extended_life_span0.78301296
107MP0003787_abnormal_imprinting0.77983592
108MP0002723_abnormal_immune_serum0.77856442
109MP0002161_abnormal_fertility/fecundity0.77676066
110MP0002420_abnormal_adaptive_immunity0.77508539
111MP0002925_abnormal_cardiovascular_devel0.77347264
112MP0000383_abnormal_hair_follicle0.76394418
113MP0001819_abnormal_immune_cell0.76225455
114MP0005384_cellular_phenotype0.75283890
115MP0001853_heart_inflammation0.74034944
116MP0005464_abnormal_platelet_physiology0.72808412
117MP0009333_abnormal_splenocyte_physiolog0.72738399
118MP0002060_abnormal_skin_morphology0.72573959
119MP0009053_abnormal_anal_canal0.71452584
120MP0002138_abnormal_hepatobiliary_system0.70990625
121MP0003943_abnormal_hepatobiliary_system0.70576166
122MP0001845_abnormal_inflammatory_respons0.70477952
123MP0003866_abnormal_defecation0.69773436
124MP0002998_abnormal_bone_remodeling0.69257882
125MP0003045_fibrosis0.68454314
126MP0003567_abnormal_fetal_cardiomyocyte0.68014356
127MP0003950_abnormal_plasma_membrane0.66474183
128MP0001790_abnormal_immune_system0.66430420
129MP0005075_abnormal_melanosome_morpholog0.65604741
130MP0008995_early_reproductive_senescence0.64886974
131MP0003724_increased_susceptibility_to0.64536845

Predicted human phenotypes

RankGene SetZ-score
1Colitis (HP:0002583)3.95903671
2Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.63588117
3Panhypogammaglobulinemia (HP:0003139)3.50577537
4Viral hepatitis (HP:0006562)3.32445866
5Absent frontal sinuses (HP:0002688)3.20399503
6Abnormality of the fingertips (HP:0001211)3.06261641
7Agammaglobulinemia (HP:0004432)3.04835317
8IgA deficiency (HP:0002720)3.01309897
9Overlapping toe (HP:0001845)2.96051134
10Volvulus (HP:0002580)2.89678992
11Heterotopia (HP:0002282)2.88851459
12Prominent nose (HP:0000448)2.81662334
13IgM deficiency (HP:0002850)2.81600793
14Inflammation of the large intestine (HP:0002037)2.79437180
15Abnormality of T cell number (HP:0011839)2.78789413
16Absent/shortened dynein arms (HP:0200106)2.77311257
17Dynein arm defect of respiratory motile cilia (HP:0012255)2.77311257
18Chromsome breakage (HP:0040012)2.75550014
19Gastrointestinal inflammation (HP:0004386)2.67993776
20Selective tooth agenesis (HP:0001592)2.66316599
21Acute myeloid leukemia (HP:0004808)2.64934346
22Abnormality of chromosome stability (HP:0003220)2.57994983
23Ectopic kidney (HP:0000086)2.55368022
24Chromosomal breakage induced by crosslinking agents (HP:0003221)2.49948447
25Nasal polyposis (HP:0100582)2.44767496
26Impulsivity (HP:0100710)2.44502503
27Submucous cleft hard palate (HP:0000176)2.43716831
28Papillary thyroid carcinoma (HP:0002895)2.39402707
29Severe combined immunodeficiency (HP:0004430)2.38420551
30Abnormal delayed hypersensitivity skin test (HP:0002963)2.37349196
31Scanning speech (HP:0002168)2.34017767
32Abnormality of the lower motor neuron (HP:0002366)2.32201817
33Nephroblastoma (Wilms tumor) (HP:0002667)2.31989563
34Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.31685811
35Upper motor neuron abnormality (HP:0002127)2.30090028
36Chin dimple (HP:0010751)2.29866091
37High pitched voice (HP:0001620)2.24636557
38Hematochezia (HP:0002573)2.24174731
39Ependymoma (HP:0002888)2.24115607
40Chronic mucocutaneous candidiasis (HP:0002728)2.23510161
41Recurrent cutaneous fungal infections (HP:0011370)2.23510161
42Short 4th metacarpal (HP:0010044)2.22452471
43Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.22452471
44Combined immunodeficiency (HP:0005387)2.21981358
45Abnormality of T cells (HP:0002843)2.21693674
46Recurrent fungal infections (HP:0002841)2.20172721
4711 pairs of ribs (HP:0000878)2.19568425
48Chronic diarrhea (HP:0002028)2.19346383
49Meningitis (HP:0001287)2.19336773
50Embryonal renal neoplasm (HP:0011794)2.19304120
51Rhinitis (HP:0012384)2.19181063
52Acute lymphatic leukemia (HP:0006721)2.17084409
53Cutaneous melanoma (HP:0012056)2.15147312
54B lymphocytopenia (HP:0010976)2.14210223
55Recurrent bacterial skin infections (HP:0005406)2.13883936
56Autoimmune hemolytic anemia (HP:0001890)2.13469772
57Sandal gap (HP:0001852)2.12839674
58Broad palm (HP:0001169)2.12467850
59Osteolytic defects of the hand bones (HP:0009699)2.12300012
60Osteolytic defects of the phalanges of the hand (HP:0009771)2.12300012
61Gastrointestinal stroma tumor (HP:0100723)2.11168492
62Myelodysplasia (HP:0002863)2.10184215
63Lymphopenia (HP:0001888)2.10003149
64Mediastinal lymphadenopathy (HP:0100721)2.09879438
65Long eyelashes (HP:0000527)2.08648641
66Fatigue (HP:0012378)2.07021945
67Disinhibition (HP:0000734)2.06721255
68Recurrent sinusitis (HP:0011108)2.06568083
69Chronic bronchitis (HP:0004469)2.06134437
70Eczematoid dermatitis (HP:0000976)2.04880984
71Deviation of the thumb (HP:0009603)2.04719980
72Increased nuchal translucency (HP:0010880)2.04667085
73Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.03968302
74Hypoplasia of the thymus (HP:0000778)2.03421094
75Subacute progressive viral hepatitis (HP:0006572)2.03269401
76Hepatitis (HP:0012115)2.02218204
77Neonatal hypoglycemia (HP:0001998)1.99710164
78Biliary tract neoplasm (HP:0100574)1.99580089
79Conjunctival telangiectasia (HP:0000524)1.98893327
80Deep philtrum (HP:0002002)1.98705466
81Increased density of long bones (HP:0006392)1.98475995
82Degeneration of anterior horn cells (HP:0002398)1.97609980
83Abnormality of the anterior horn cell (HP:0006802)1.97609980
84Agnosia (HP:0010524)1.97388385
85Dysmetric saccades (HP:0000641)1.96670543
86Abnormality of the astrocytes (HP:0100707)1.96459506
87Astrocytoma (HP:0009592)1.96459506
88Hypopigmentation of the fundus (HP:0007894)1.96339020
89Abnormality of cells of the lymphoid lineage (HP:0012140)1.95090664
90Medulloblastoma (HP:0002885)1.93631931
91Vertebral arch anomaly (HP:0008438)1.93577096
92Abnormality of B cell number (HP:0010975)1.92822359
93Thyroiditis (HP:0100646)1.92601505
94Thoracolumbar scoliosis (HP:0002944)1.91904460
95Truncal obesity (HP:0001956)1.90911397
96Abnormal respiratory motile cilium physiology (HP:0012261)1.90646687
97Thrombocytosis (HP:0001894)1.90120933
98Proximal placement of thumb (HP:0009623)1.89048925
99Transitional cell carcinoma of the bladder (HP:0006740)1.88981879
100Macroorchidism (HP:0000053)1.88867009
101Hepatoblastoma (HP:0002884)1.88792132
102Bronchitis (HP:0012387)1.88277259
103Vasculitis (HP:0002633)1.88071194
104Cellulitis (HP:0100658)1.87946828
105Sloping forehead (HP:0000340)1.87680506
106Neoplasm of striated muscle (HP:0009728)1.87499803
107Basal cell carcinoma (HP:0002671)1.84953771
108Abnormality of the nasal mucosa (HP:0000433)1.83837806
109Entropion (HP:0000621)1.83629541
110Narrow palate (HP:0000189)1.83604619
111Lymphoma (HP:0002665)1.83437359
112Neoplasm of the oral cavity (HP:0100649)1.80630920
113Somatic mutation (HP:0001428)1.80528633
114Abnormality of T cell physiology (HP:0011840)1.79231367
115Anal stenosis (HP:0002025)1.78146952
116Bladder carcinoma (HP:0002862)1.77197897
117Bladder neoplasm (HP:0009725)1.77197897
118Breast carcinoma (HP:0003002)1.77068542
119Recurrent viral infections (HP:0004429)1.76641664
120Renovascular hypertension (HP:0100817)1.76622370
121Recurrent bronchitis (HP:0002837)1.76372473
122Gastrointestinal carcinoma (HP:0002672)1.75217605
123Malignant gastrointestinal tract tumors (HP:0006749)1.75217605
124Glioma (HP:0009733)1.74881557
125Cafe-au-lait spot (HP:0000957)1.74823970
126Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.74090694
127Dislocated radial head (HP:0003083)1.73760444
128Amaurosis fugax (HP:0100576)1.73606161
129Osteomyelitis (HP:0002754)1.73386744
130Granulocytopenia (HP:0001913)1.73172288
131Abnormality of chromosome segregation (HP:0002916)1.72618669
132Abnormality of the carotid arteries (HP:0005344)1.72124128
133Limited elbow extension (HP:0001377)1.72123208
134IgG deficiency (HP:0004315)1.71580948
135Gonadotropin excess (HP:0000837)1.71096467
136Clubbing of toes (HP:0100760)1.70328543
137Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.69960320
138Relative macrocephaly (HP:0004482)1.69058503
139Syringomyelia (HP:0003396)1.68440419
140Spinal cord lesions (HP:0100561)1.68440419
141Uterine leiomyosarcoma (HP:0002891)1.68354826
142Leiomyosarcoma (HP:0100243)1.68354826
143Abnormality of the frontal sinuses (HP:0002687)1.67534103
144Persistence of primary teeth (HP:0006335)1.66028661
145Birth length less than 3rd percentile (HP:0003561)1.65830362
146Low anterior hairline (HP:0000294)1.65813907
147Bicuspid aortic valve (HP:0001647)1.65637507
148Small intestinal stenosis (HP:0012848)1.65564138
149Duodenal stenosis (HP:0100867)1.65564138
150Cutis marmorata (HP:0000965)1.64316126
151Missing ribs (HP:0000921)1.63199755
152T lymphocytopenia (HP:0005403)1.61768821
153Rectal prolapse (HP:0002035)1.61528064
154Bronchiectasis (HP:0002110)1.61478309
155Thyroid carcinoma (HP:0002890)1.61435855
156Aplasia/Hypoplasia of the uvula (HP:0010293)1.60949225
157Urethral obstruction (HP:0000796)1.60821803
158Abnormality of the vasculature of the conjunctiva (HP:0008054)1.60145453
159Rhabdomyosarcoma (HP:0002859)1.59077753
160Abnormality of the radial head (HP:0003995)1.58417030
161Poikilocytosis (HP:0004447)1.58007858
162Colon cancer (HP:0003003)1.57973925
163Ankle contracture (HP:0006466)1.57335435
164Squamous cell carcinoma (HP:0002860)1.56644938
165Abnormal respiratory motile cilium morphology (HP:0005938)1.56487880
166Abnormal respiratory epithelium morphology (HP:0012253)1.56487880

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.31093960
2CDC73.57177403
3NEK22.83392787
4PDK32.67190148
5PDK42.67190148
6PRPF4B2.67049788
7EEF2K2.66304296
8RIPK42.48042382
9SCYL22.26172967
10STK32.21083771
11LATS12.11802170
12MAP3K102.07368439
13BMPR22.03605931
14WEE11.94203318
15NLK1.82445562
16TTK1.81500549
17ATR1.74171359
18BTK1.72655665
19FGFR41.70736121
20STK101.68448870
21NEK91.65114041
22BRD41.62410449
23PDK21.62314180
24TEC1.54401605
25MAP3K131.51431361
26CAMK1D1.46964014
27BRSK21.45310274
28CHEK11.43212798
29EIF2AK11.40404394
30MAP3K141.40223329
31IKBKE1.37057334
32RPS6KA41.35893249
33PKN21.35165133
34CDK61.34706426
35SRPK11.34609802
36ZAK1.31841634
37MAP4K11.30414748
38STK41.28718546
39PASK1.28173589
40TTN1.27765667
41ATM1.26791174
42SYK1.26429957
43CDK41.25225815
44MTOR1.21277940
45ACVR1B1.20423701
46AURKB1.20016687
47RPS6KB21.19917999
48FRK1.17855730
49MAP3K81.16597207
50CHEK21.16457246
51BLK1.12834971
52SGK21.12687059
53PIM11.12546812
54YES11.12067767
55PTK61.09606476
56PLK11.07201306
57CAMK1G1.05174064
58FGFR31.05047177
59RIPK11.01420155
60TYK21.00464911
61IRAK40.99745236
62JAK30.97173795
63ALK0.96809444
64EPHA30.95815881
65MELK0.95233601
66PLK30.95127472
67WNK10.94257962
68TSSK60.93976052
69IRAK10.93743104
70DYRK30.93683388
71FLT30.92591711
72MKNK10.92257665
73MAP3K70.92076557
74CHUK0.91384941
75AKT30.90520642
76EIF2AK30.90401251
77TXK0.88447409
78SGK30.87920905
79PLK40.87061427
80PDGFRB0.86484702
81CDK70.83145812
82MAPK110.82979646
83MAP2K30.82638700
84CDK20.80708111
85JAK10.79743255
86CDK80.78353766
87RET0.76902075
88CSK0.75947279
89KIT0.75491199
90LCK0.75196245
91TRPM70.74930909
92CSF1R0.74603864
93MKNK20.73464121
94LYN0.73054023
95PNCK0.69224370
96PAK20.68390580
97STK240.67792538
98RPS6KA50.64747527
99MAPK70.64194236
100STK38L0.62735605
101IKBKB0.62391713
102CDK10.60871520
103EPHA20.60834080
104MAP3K30.60152062
105FGFR10.59201055
106PDGFRA0.57911127
107CDK90.57858843
108PRKDC0.56589012
109FGFR20.55598847
110MAPK100.54984571
111MAP3K40.54861179
112TLK10.54383652
113EIF2AK20.53683744
114FGR0.53591315
115CDK30.53259335
116PDK10.52903257
117NUAK10.52841490
118RPS6KB10.52308039
119* CSNK1D0.51497579
120FES0.51262442
121MARK30.49880026
122TGFBR10.49538915
123TAOK30.49460564
124TBK10.49402001
125JAK20.49176917
126SMG10.48767943
127SIK20.48717974
128ICK0.48104365
129MAP3K60.47390802
130BMX0.47383002
131IRAK20.46313374
132LRRK20.46244679
133ITK0.45930922
134SGK2230.45521204
135SGK4940.45521204
136MAP3K20.43510746
137TRIB30.42742626
138TGFBR20.42180267
139MAPK140.41871089
140ZAP700.41851332
141HCK0.41703395
142EGFR0.41521357
143NEK10.41508071
144TYRO30.41347023
145PAK40.40501404
146MAPK10.37221277
147ERBB30.34990103

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053222.46777827
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.45126129
3One carbon pool by folate_Homo sapiens_hsa006702.41083670
4RNA transport_Homo sapiens_hsa030132.36368978
5Cell cycle_Homo sapiens_hsa041102.27099772
6DNA replication_Homo sapiens_hsa030302.22864735
7Non-homologous end-joining_Homo sapiens_hsa034502.00310376
8Fanconi anemia pathway_Homo sapiens_hsa034601.93550666
9Mismatch repair_Homo sapiens_hsa034301.91977226
10mRNA surveillance pathway_Homo sapiens_hsa030151.84044832
11Graft-versus-host disease_Homo sapiens_hsa053321.71510269
12Viral carcinogenesis_Homo sapiens_hsa052031.71340098
13Autoimmune thyroid disease_Homo sapiens_hsa053201.66036343
14p53 signaling pathway_Homo sapiens_hsa041151.64705165
15Antigen processing and presentation_Homo sapiens_hsa046121.58589462
16Asthma_Homo sapiens_hsa053101.56149654
17Selenocompound metabolism_Homo sapiens_hsa004501.55945057
18Herpes simplex infection_Homo sapiens_hsa051681.53354701
19Small cell lung cancer_Homo sapiens_hsa052221.52587473
20Spliceosome_Homo sapiens_hsa030401.51644437
21Homologous recombination_Homo sapiens_hsa034401.47750531
22MicroRNAs in cancer_Homo sapiens_hsa052061.47744730
23NF-kappa B signaling pathway_Homo sapiens_hsa040641.46734732
24Chronic myeloid leukemia_Homo sapiens_hsa052201.46204017
25Base excision repair_Homo sapiens_hsa034101.45231835
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.43277032
27Type I diabetes mellitus_Homo sapiens_hsa049401.41829222
28Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.36827975
29Nucleotide excision repair_Homo sapiens_hsa034201.35014807
30B cell receptor signaling pathway_Homo sapiens_hsa046621.33470581
31Phosphatidylinositol signaling system_Homo sapiens_hsa040701.28768330
32RNA degradation_Homo sapiens_hsa030181.27680684
33Basal transcription factors_Homo sapiens_hsa030221.27112666
34HTLV-I infection_Homo sapiens_hsa051661.24374508
35Transcriptional misregulation in cancer_Homo sapiens_hsa052021.23352435
36Lysine degradation_Homo sapiens_hsa003101.23135805
37Measles_Homo sapiens_hsa051621.21871370
38Vitamin B6 metabolism_Homo sapiens_hsa007501.13099222
39Toxoplasmosis_Homo sapiens_hsa051451.11913652
40Osteoclast differentiation_Homo sapiens_hsa043801.11184003
41NOD-like receptor signaling pathway_Homo sapiens_hsa046211.09318222
42Choline metabolism in cancer_Homo sapiens_hsa052311.08573408
43Apoptosis_Homo sapiens_hsa042101.07981994
44mTOR signaling pathway_Homo sapiens_hsa041501.07482226
45Epstein-Barr virus infection_Homo sapiens_hsa051691.04036133
46Influenza A_Homo sapiens_hsa051641.03274432
47Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.03164460
48Staphylococcus aureus infection_Homo sapiens_hsa051501.02487626
49Hepatitis B_Homo sapiens_hsa051611.01020892
50Dorso-ventral axis formation_Homo sapiens_hsa043201.00702151
51Adherens junction_Homo sapiens_hsa045201.00510122
52Legionellosis_Homo sapiens_hsa051340.98744364
53Acute myeloid leukemia_Homo sapiens_hsa052210.98470543
54T cell receptor signaling pathway_Homo sapiens_hsa046600.97649457
55Renal cell carcinoma_Homo sapiens_hsa052110.96106797
56Oocyte meiosis_Homo sapiens_hsa041140.94517621
57Leishmaniasis_Homo sapiens_hsa051400.93431091
58Pancreatic cancer_Homo sapiens_hsa052120.90685941
59Prostate cancer_Homo sapiens_hsa052150.90294838
60ErbB signaling pathway_Homo sapiens_hsa040120.89372118
61TNF signaling pathway_Homo sapiens_hsa046680.89218442
62Alcoholism_Homo sapiens_hsa050340.88402493
63Viral myocarditis_Homo sapiens_hsa054160.87807372
64Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.86487343
65Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.81873898
66Jak-STAT signaling pathway_Homo sapiens_hsa046300.79970224
67Platelet activation_Homo sapiens_hsa046110.78286754
68Type II diabetes mellitus_Homo sapiens_hsa049300.78280339
69TGF-beta signaling pathway_Homo sapiens_hsa043500.77915505
70Central carbon metabolism in cancer_Homo sapiens_hsa052300.77590618
71Hematopoietic cell lineage_Homo sapiens_hsa046400.75862996
72Thyroid cancer_Homo sapiens_hsa052160.73842769
73Endometrial cancer_Homo sapiens_hsa052130.73728308
74Colorectal cancer_Homo sapiens_hsa052100.73557728
75Proteoglycans in cancer_Homo sapiens_hsa052050.72781143
76Non-small cell lung cancer_Homo sapiens_hsa052230.72323571
77Primary immunodeficiency_Homo sapiens_hsa053400.71352261
78Circadian rhythm_Homo sapiens_hsa047100.70878530
79RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.70588206
80Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.70335829
81Toll-like receptor signaling pathway_Homo sapiens_hsa046200.70063807
82Other glycan degradation_Homo sapiens_hsa005110.69811581
83Prolactin signaling pathway_Homo sapiens_hsa049170.68345563
84FoxO signaling pathway_Homo sapiens_hsa040680.67601166
85Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65984848
86Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.65889226
87Chemokine signaling pathway_Homo sapiens_hsa040620.63895998
88Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.61377117
89Focal adhesion_Homo sapiens_hsa045100.59744255
90Sphingolipid signaling pathway_Homo sapiens_hsa040710.59295787
91Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.59267130
92Leukocyte transendothelial migration_Homo sapiens_hsa046700.57837608
93ECM-receptor interaction_Homo sapiens_hsa045120.57689426
94Inositol phosphate metabolism_Homo sapiens_hsa005620.55860387
95Pentose phosphate pathway_Homo sapiens_hsa000300.55838600
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.55425751
97Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.53656398
98Neurotrophin signaling pathway_Homo sapiens_hsa047220.52819298
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52090175
100Malaria_Homo sapiens_hsa051440.51815895
101Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.51812246
102Hepatitis C_Homo sapiens_hsa051600.51448859
103AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.50947721
104Tuberculosis_Homo sapiens_hsa051520.50386337
105Shigellosis_Homo sapiens_hsa051310.49470355
106VEGF signaling pathway_Homo sapiens_hsa043700.49303945
107Intestinal immune network for IgA production_Homo sapiens_hsa046720.48920901
108Insulin resistance_Homo sapiens_hsa049310.48367163
109GnRH signaling pathway_Homo sapiens_hsa049120.48036420
110Allograft rejection_Homo sapiens_hsa053300.47539064
111Notch signaling pathway_Homo sapiens_hsa043300.47308222
112Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.46732997
113HIF-1 signaling pathway_Homo sapiens_hsa040660.46440621
114Pathways in cancer_Homo sapiens_hsa052000.46308526
115Glucagon signaling pathway_Homo sapiens_hsa049220.46110214
116Adipocytokine signaling pathway_Homo sapiens_hsa049200.45440506
117Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43583729
118Glioma_Homo sapiens_hsa052140.43555213

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