BSPRY

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)9.50917523
2fusion of sperm to egg plasma membrane (GO:0007342)9.45526280
3cell wall macromolecule metabolic process (GO:0044036)8.61126654
4cell wall macromolecule catabolic process (GO:0016998)8.61126654
5sperm-egg recognition (GO:0035036)8.43301108
6acrosome assembly (GO:0001675)8.35267324
7acrosome reaction (GO:0007340)7.96473866
8binding of sperm to zona pellucida (GO:0007339)7.85340107
9cell-cell recognition (GO:0009988)7.77507341
10multicellular organism reproduction (GO:0032504)7.68141628
11spermatid development (GO:0007286)7.57468692
12axonemal dynein complex assembly (GO:0070286)7.38866248
13cilium or flagellum-dependent cell motility (GO:0001539)7.31534252
14piRNA metabolic process (GO:0034587)7.07355877
15motile cilium assembly (GO:0044458)6.95287101
16plasma membrane fusion (GO:0045026)6.87888434
17synaptonemal complex assembly (GO:0007130)6.68551723
18reproduction (GO:0000003)6.64263776
19synaptonemal complex organization (GO:0070193)6.62325312
20epithelial cilium movement (GO:0003351)6.46925943
21male meiosis (GO:0007140)6.30283583
22regulation of cilium movement (GO:0003352)5.91179532
23interferon-gamma secretion (GO:0072643)5.88387981
24negative regulation of inclusion body assembly (GO:0090084)5.56009456
25sperm capacitation (GO:0048240)5.45963476
26cilium movement (GO:0003341)5.44411228
27single fertilization (GO:0007338)5.35788351
28spermatogenesis (GO:0007283)5.25935438
29male gamete generation (GO:0048232)5.24089685
30organic cation transport (GO:0015695)5.13062075
31epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.97428341
32aggressive behavior (GO:0002118)4.85178466
33fertilization (GO:0009566)4.85031307
34gamete generation (GO:0007276)4.84110497
35male meiosis I (GO:0007141)4.75772340
36seminiferous tubule development (GO:0072520)4.67148915
37chromosome condensation (GO:0030261)4.58065033
38regulation of inclusion body assembly (GO:0090083)4.50664327
39DNA methylation involved in gamete generation (GO:0043046)4.48940648
40regulation of female receptivity (GO:0045924)4.46769564
41short-chain fatty acid metabolic process (GO:0046459)4.46056568
42trivalent inorganic anion homeostasis (GO:0072506)4.41732872
43phosphate ion homeostasis (GO:0055062)4.41732872
44DNA packaging (GO:0006323)4.40218843
45germ cell development (GO:0007281)4.30316280
46chromosome organization involved in meiosis (GO:0070192)4.27263437
47female mating behavior (GO:0060180)4.26192514
48cellular process involved in reproduction in multicellular organism (GO:0022412)4.26156160
49microtubule severing (GO:0051013)4.25809379
50microtubule depolymerization (GO:0007019)4.20869116
51hemidesmosome assembly (GO:0031581)4.17977455
52meiosis I (GO:0007127)4.08322824
53phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)4.02661072
54intestinal epithelial cell development (GO:0060576)3.98907916
55meiotic nuclear division (GO:0007126)3.94087689
56definitive hemopoiesis (GO:0060216)3.89397896
57multicellular organismal reproductive process (GO:0048609)3.84394061
58iron-sulfur cluster assembly (GO:0016226)3.79922597
59metallo-sulfur cluster assembly (GO:0031163)3.79922597
60meiotic cell cycle (GO:0051321)3.63735931
61branched-chain amino acid catabolic process (GO:0009083)3.56609661
62glutathione derivative metabolic process (GO:1901685)3.49206144
63glutathione derivative biosynthetic process (GO:1901687)3.49206144
64chaperone-mediated protein complex assembly (GO:0051131)3.47965892
65monoubiquitinated protein deubiquitination (GO:0035520)3.47853915
66multicellular organismal water homeostasis (GO:0050891)3.46816882
67cellular anion homeostasis (GO:0030002)3.38317764
68gene silencing by RNA (GO:0031047)3.37232717
69negative regulation of cell size (GO:0045792)3.36460853
70regulation of microtubule-based movement (GO:0060632)3.30287615
71hyperosmotic salinity response (GO:0042538)3.29540364
72glutathione biosynthetic process (GO:0006750)3.27901786
73preassembly of GPI anchor in ER membrane (GO:0016254)3.25810863
74cell recognition (GO:0008037)3.20723218
75mitochondrial calcium ion transport (GO:0006851)3.14348054
76spermatid nucleus differentiation (GO:0007289)3.12670189
77single strand break repair (GO:0000012)3.11247845
78bundle of His cell to Purkinje myocyte communication (GO:0086069)3.11164290
79phosphatidylglycerol biosynthetic process (GO:0006655)3.10752116
80xenobiotic catabolic process (GO:0042178)3.10026166
81rRNA catabolic process (GO:0016075)3.09738404
82negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.08940485
83autophagic vacuole fusion (GO:0000046)3.08628651
84heme biosynthetic process (GO:0006783)3.06688414
85protein autoprocessing (GO:0016540)3.06624169
86establishment of skin barrier (GO:0061436)3.05992618
87multicellular organismal development (GO:0007275)3.05860546
88membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.05408175
89water homeostasis (GO:0030104)3.04556517
90GPI anchor biosynthetic process (GO:0006506)3.02812124
91mannosylation (GO:0097502)3.01866214
92response to parathyroid hormone (GO:0071107)3.00868112
93sexual reproduction (GO:0019953)3.00691295
94grooming behavior (GO:0007625)2.98594983
95nitric oxide biosynthetic process (GO:0006809)2.96088877
96calcium ion-dependent exocytosis (GO:0017156)2.95223894
97glycerol ether metabolic process (GO:0006662)2.93879265
98carnitine transport (GO:0015879)2.93374030
99amino-acid betaine transport (GO:0015838)2.93374030
100nonribosomal peptide biosynthetic process (GO:0019184)2.91997187
101response to lead ion (GO:0010288)2.91936903
102regulation of transmission of nerve impulse (GO:0051969)2.89980866
103sulfate transmembrane transport (GO:1902358)2.89520054
104sphingomyelin metabolic process (GO:0006684)2.88098549
105ventricular system development (GO:0021591)2.87301049
106regulation of spindle checkpoint (GO:0090231)2.86459158
107branched-chain amino acid metabolic process (GO:0009081)2.86306149
108alditol metabolic process (GO:0019400)2.84550820
109gene silencing (GO:0016458)2.84221982
110aerobic respiration (GO:0009060)2.83374079
111pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.82840023
112cardiolipin metabolic process (GO:0032048)2.81676749
113meiotic cell cycle process (GO:1903046)2.81029032
114vitamin transmembrane transport (GO:0035461)2.80589993
115protoporphyrinogen IX metabolic process (GO:0046501)2.80507814
116membrane repolarization during action potential (GO:0086011)2.79377019
117zinc ion transmembrane transport (GO:0071577)2.78428186
118left/right pattern formation (GO:0060972)2.77739492
119biotin metabolic process (GO:0006768)2.77292944
120positive regulation of calcium ion import (GO:0090280)2.77017876
121negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.75655780
122protein refolding (GO:0042026)2.75065494
123protein localization to chromosome, centromeric region (GO:0071459)2.74886843
124negative regulation of B cell apoptotic process (GO:0002903)2.73020160
125nucleus organization (GO:0006997)2.72282990
126negative regulation of keratinocyte proliferation (GO:0010839)2.71667841
127genitalia morphogenesis (GO:0035112)2.70944132
128pentose metabolic process (GO:0019321)2.70647686
129negative regulation of multicellular organism growth (GO:0040015)2.67665083
130regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.66956567
131carnitine transmembrane transport (GO:1902603)2.66357933
132positive regulation of Cdc42 GTPase activity (GO:0043089)2.66030895
133ether metabolic process (GO:0018904)2.65946451
134response to lipoprotein particle (GO:0055094)2.65782855
135desmosome organization (GO:0002934)2.65305381
136maintenance of gastrointestinal epithelium (GO:0030277)2.63949315
137GPI anchor metabolic process (GO:0006505)2.62203287
138mitotic sister chromatid cohesion (GO:0007064)2.61820433
139phosphatidylserine acyl-chain remodeling (GO:0036150)2.59436726
140sequestering of actin monomers (GO:0042989)2.59100198
141cellular ketone body metabolic process (GO:0046950)2.59049540
142GDP-mannose metabolic process (GO:0019673)2.59012797
143regulation of interleukin-13 production (GO:0032656)2.57522447
144deoxyribonucleotide catabolic process (GO:0009264)2.57084565
145porphyrin-containing compound biosynthetic process (GO:0006779)2.56942159
146calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.56795441
147sulfate transport (GO:0008272)2.56767121
148regulation of memory T cell differentiation (GO:0043380)2.56584299
149CD4-positive, alpha-beta T cell activation (GO:0035710)2.55569175
150regulation of water loss via skin (GO:0033561)2.55490401
151deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.55422548
152epithelial cell maturation (GO:0002070)2.54504811
153negative regulation of neurological system process (GO:0031645)2.53652452
154L-alpha-amino acid transmembrane transport (GO:1902475)2.53567956
155histone exchange (GO:0043486)2.52337611
156deoxyribose phosphate catabolic process (GO:0046386)2.49817701
157regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.49555860
158protein complex localization (GO:0031503)2.48065001
159negative regulation of erythrocyte differentiation (GO:0045647)2.45857050
160negative regulation of transcription by competitive promoter binding (GO:0010944)2.45241482
161protein kinase C signaling (GO:0070528)2.43899949
162tetrapyrrole biosynthetic process (GO:0033014)2.43595165
163polyamine biosynthetic process (GO:0006596)2.43044770
164amyloid precursor protein catabolic process (GO:0042987)2.42945945
165regulation of hippo signaling (GO:0035330)2.42276327
166alditol phosphate metabolic process (GO:0052646)2.41956776
167C-terminal protein lipidation (GO:0006501)2.41146102
168monoamine transport (GO:0015844)2.40721793
169regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2.40298211
170regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.40068525
171positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.40068525
172cellular response to arsenic-containing substance (GO:0071243)2.39852040
173maternal behavior (GO:0042711)2.39168711
174drinking behavior (GO:0042756)2.38723620
175glutathione metabolic process (GO:0006749)2.38074235
176CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.37575934
177auditory receptor cell differentiation (GO:0042491)2.37550398
178rRNA modification (GO:0000154)2.37483220
179regulation of podosome assembly (GO:0071801)2.36905998
180RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.36094647
181tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.36094647
182neurotransmitter catabolic process (GO:0042135)2.35870921
183relaxation of cardiac muscle (GO:0055119)2.35029934
184glycerol metabolic process (GO:0006071)2.34572799
185natural killer cell mediated cytotoxicity (GO:0042267)2.34491132
186organelle membrane fusion (GO:0090174)2.34168893
187regulation of B cell apoptotic process (GO:0002902)2.34148803
188nucleoside diphosphate catabolic process (GO:0009134)2.33995787
189Peyers patch development (GO:0048541)2.33405486
190mucosal-associated lymphoid tissue development (GO:0048537)2.33405486
191protoporphyrinogen IX biosynthetic process (GO:0006782)2.29250437
192regulation of respiratory burst (GO:0060263)2.29222822

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.60973850
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.68285745
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.62888498
4STAT6_21828071_ChIP-Seq_BEAS2B_Human3.37848291
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.34490210
6GATA1_22025678_ChIP-Seq_K562_Human3.01127841
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.91305256
8ELF1_17652178_ChIP-ChIP_JURKAT_Human2.81374481
9ESR1_21235772_ChIP-Seq_MCF-7_Human2.76928424
10ESR1_15608294_ChIP-ChIP_MCF-7_Human2.76189913
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.58460746
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.39902375
13SOX2_27498859_Chip-Seq_STOMACH_Mouse2.29404374
14GATA1_26923725_Chip-Seq_HPCs_Mouse2.27388593
15STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.25290913
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.22256572
17ZNF263_19887448_ChIP-Seq_K562_Human2.20762167
18* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.19459546
19SCL_19346495_ChIP-Seq_HPC-7_Human2.04258540
20KAP1_22055183_ChIP-Seq_ESCs_Mouse2.03802353
21PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.00033533
22AR_21909140_ChIP-Seq_LNCAP_Human1.98236669
23ESR1_20079471_ChIP-ChIP_T-47D_Human1.95465806
24KDM5A_27292631_Chip-Seq_BREAST_Human1.94656106
25SRF_21415370_ChIP-Seq_HL-1_Mouse1.87774691
26ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.82845275
27FOXM1_23109430_ChIP-Seq_U2OS_Human1.80750298
28GATA3_24758297_ChIP-Seq_MCF-7_Human1.78425393
29VDR_22108803_ChIP-Seq_LS180_Human1.77883475
30FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.76696193
31GATA4_25053715_ChIP-Seq_YYC3_Human1.73284664
32IRF8_22096565_ChIP-ChIP_GC-B_Human1.71877784
33EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.71868708
34STAT1_17558387_ChIP-Seq_HELA_Human1.69955116
35TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.68711741
36MYC_18358816_ChIP-ChIP_MESCs_Mouse1.68414051
37BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.68060936
38GATA6_25053715_ChIP-Seq_YYC3_Human1.65627746
39RUNX1_27514584_Chip-Seq_MCF-7_Human1.60535065
40HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.59447300
41MYC_18555785_ChIP-Seq_MESCs_Mouse1.58667278
42EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.57674796
43* GATA3_21867929_ChIP-Seq_CD8_Mouse1.53768642
44ETS1_20019798_ChIP-Seq_JURKAT_Human1.52254557
45TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.51371839
46SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.50604835
47SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49830386
48EGR1_23403033_ChIP-Seq_LIVER_Mouse1.49577774
49RXR_22158963_ChIP-Seq_LIVER_Mouse1.44009547
50CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.43946157
51GABP_19822575_ChIP-Seq_HepG2_Human1.43456176
52CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.43114773
53CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42852235
54PPARA_22158963_ChIP-Seq_LIVER_Mouse1.42765801
55DCP1A_22483619_ChIP-Seq_HELA_Human1.42171710
56SOX2_22085726_ChIP-Seq_NPCs_Mouse1.39283898
57CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.38461142
58RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37565941
59TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.37395763
60ERG_20517297_ChIP-Seq_VCAP_Human1.37270462
61KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.37247685
62ELF5_23300383_ChIP-Seq_T47D_Human1.36742686
63FOXA1_25552417_ChIP-Seq_VCAP_Human1.36428571
64PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.36421485
65FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.36329352
66FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.35842673
67BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.34023042
68BCOR_27268052_Chip-Seq_Bcells_Human1.32967039
69KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.32612768
70VDR_23849224_ChIP-Seq_CD4+_Human1.30926990
71STAT3_1855785_ChIP-Seq_MESCs_Mouse1.30469885
72ERG_20887958_ChIP-Seq_HPC-7_Mouse1.30439999
73FOXP3_21729870_ChIP-Seq_TREG_Human1.29984442
74SRY_22984422_ChIP-ChIP_TESTIS_Rat1.29421798
75P53_21459846_ChIP-Seq_SAOS-2_Human1.29250500
76FOXO3_23340844_ChIP-Seq_DLD1_Human1.26900842
77ZFX_18555785_ChIP-Seq_MESCs_Mouse1.26861795
78HOXB4_20404135_ChIP-ChIP_EML_Mouse1.22548059
79HIF1A_21447827_ChIP-Seq_MCF-7_Human1.22070005
80ELK4_26923725_Chip-Seq_MESODERM_Mouse1.21976107
81TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21332703
82PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.20764070
83ERA_21632823_ChIP-Seq_H3396_Human1.20733847
84SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.20270665
85LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.18772856
86TET1_21451524_ChIP-Seq_MESCs_Mouse1.18531190
87RAD21_21589869_ChIP-Seq_MESCs_Mouse1.18460524
88VDR_21846776_ChIP-Seq_THP-1_Human1.18205275
89ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.17719336
90PHF8_20622854_ChIP-Seq_HELA_Human1.17611931
91CTCF_20526341_ChIP-Seq_ESCs_Human1.15438316
92FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.15127169
93FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.14939240
94FLI1_21867929_ChIP-Seq_CD8_Mouse1.14906255
95* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.14457708
96E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.14189179
97* BCL6_27268052_Chip-Seq_Bcells_Human1.14066597
98P63_26484246_Chip-Seq_KERATINOCYTES_Human1.13992638
99JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.13799999
100RARA_24833708_ChIP-Seq_LIVER_Mouse1.13725928
101SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.13710360
102LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.13328391
103ZNF274_21170338_ChIP-Seq_K562_Hela1.12497700
104AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.11911517
105TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.10554703
106KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.09857073
107GATA1_19941826_ChIP-Seq_K562_Human1.08925018
108NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.08574613
109CTCF_26484167_Chip-Seq_Bcells_Mouse1.08317919
110LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.07549039
111BP1_19119308_ChIP-ChIP_Hs578T_Human1.07067543
112TP63_22573176_ChIP-Seq_HFKS_Human1.06520915
113YY1_21170310_ChIP-Seq_MESCs_Mouse1.06398048
114CIITA_25753668_ChIP-Seq_RAJI_Human1.06332282
115ELF1_20517297_ChIP-Seq_JURKAT_Human1.06143912
116WDR5_24793694_ChIP-Seq_LNCAP_Human1.05981547
117SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.04638144
118E2F1_18555785_ChIP-Seq_MESCs_Mouse1.04079448
119CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.04010357
120ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03902186
121SPI1_26923725_Chip-Seq_HPCs_Mouse1.03735881
122RXRA_24833708_ChIP-Seq_LIVER_Mouse1.03468234
123* SOX2_20726797_ChIP-Seq_SW620_Human1.03257228
124PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.02542173
125* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.02443434
126PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01771320
127CTCF_21964334_ChIP-Seq_BJAB-B_Human1.01573698
128ATF3_27146783_Chip-Seq_COLON_Human1.01568459
129ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01520502
130* TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.00890107
131* CTCF_18555785_ChIP-Seq_MESCs_Mouse0.99921215
132KLF5_25053715_ChIP-Seq_YYC3_Human0.99762408
133RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.99418542
134MYC_27129775_Chip-Seq_CORNEA_Mouse0.99337834
135GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.99022145
136CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98516601
137EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.98216490
138* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98206997
139NANOG_20526341_ChIP-Seq_ESCs_Human0.97865099
140TFEB_21752829_ChIP-Seq_HELA_Human0.97736307
141KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.96994891
142* FOXP1_21924763_ChIP-Seq_HESCs_Human0.96909568
143RUNX1_26923725_Chip-Seq_HPCs_Mouse0.96823285
144YY1_22570637_ChIP-Seq_MALME-3M_Human0.96731976
145FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96189918
146CDX2_20551321_ChIP-Seq_CACO-2_Human0.95733352
147LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.95297673
148ESR2_21235772_ChIP-Seq_MCF-7_Human0.94592179
149RARB_24833708_ChIP-Seq_LIVER_Mouse0.94199009
150SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.92844899
151PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91586752
152KAP1_27257070_Chip-Seq_ESCs_Mouse0.90891860
153P68_20966046_ChIP-Seq_HELA_Human0.90510318
154SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.89974872
155NANOG_18692474_ChIP-Seq_MEFs_Mouse0.89419576
156* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.88654173
157SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.88190881
158ESET_19884257_ChIP-Seq_ESCs_Mouse0.87549464
159* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.86367307
160FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.86315753
161P300_27268052_Chip-Seq_Bcells_Human0.85833666
162EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.85755018
163* SOX2_21211035_ChIP-Seq_LN229_Human0.85415081
164RACK7_27058665_Chip-Seq_MCF-7_Human0.84978093
165STAT1_20625510_ChIP-Seq_HELA_Human0.84074313
166E2F1_20622854_ChIP-Seq_HELA_Human0.83813250
167SMC4_20622854_ChIP-Seq_HELA_Human0.83608990
168GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.83142869
169KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.82951815
170CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.82780561
171BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.82491064
172GATA3_21867929_ChIP-Seq_TH1_Mouse0.82240182
173PPAR_26484153_Chip-Seq_NCI-H1993_Human0.81960675
174RAC3_21632823_ChIP-Seq_H3396_Human0.81060268

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization9.09733460
2MP0000678_abnormal_parathyroid_gland5.88621683
3MP0010234_abnormal_vibrissa_follicle5.01785134
4MP0002254_reproductive_system_inflammat4.34644100
5MP0003698_abnormal_male_reproductive3.45179892
6MP0001929_abnormal_gametogenesis3.42933329
7MP0002909_abnormal_adrenal_gland2.85107077
8MP0004264_abnormal_extraembryonic_tissu2.79022506
9MP0008877_abnormal_DNA_methylation2.63889096
10MP0003195_calcinosis2.63452732
11MP0004147_increased_porphyrin_level2.58935958
12MP0001873_stomach_inflammation2.57527286
13MP0003806_abnormal_nucleotide_metabolis2.56946136
14MP0005310_abnormal_salivary_gland2.36932020
15MP0000516_abnormal_urinary_system2.27655073
16MP0005367_renal/urinary_system_phenotyp2.27655073
17MP0003693_abnormal_embryo_hatching2.22602861
18MP0002210_abnormal_sex_determination2.21202324
19MP0009278_abnormal_bone_marrow2.20954830
20MP0000462_abnormal_digestive_system2.19179402
21MP0001849_ear_inflammation2.16404140
22MP0005645_abnormal_hypothalamus_physiol2.14455406
23MP0002796_impaired_skin_barrier2.09994339
24MP0000537_abnormal_urethra_morphology2.08997599
25MP0001145_abnormal_male_reproductive1.99686599
26MP0005075_abnormal_melanosome_morpholog1.93917887
27MP0002161_abnormal_fertility/fecundity1.90891971
28MP0001346_abnormal_lacrimal_gland1.85063163
29MP0002160_abnormal_reproductive_system1.79028414
30MP0000653_abnormal_sex_gland1.77348836
31MP0002653_abnormal_ependyma_morphology1.74374130
32MP0005220_abnormal_exocrine_pancreas1.73977015
33MP0002822_catalepsy1.73507974
34MP0001545_abnormal_hematopoietic_system1.72325410
35MP0005397_hematopoietic_system_phenotyp1.72325410
36MP0000566_synostosis1.70440093
37MP0003186_abnormal_redox_activity1.69652009
38MP0010678_abnormal_skin_adnexa1.66393697
39MP0006036_abnormal_mitochondrial_physio1.61780641
40MP0003656_abnormal_erythrocyte_physiolo1.61422012
41MP0010352_gastrointestinal_tract_polyps1.60603230
42MP0005377_hearing/vestibular/ear_phenot1.58950351
43MP0003878_abnormal_ear_physiology1.58950351
44MP0002396_abnormal_hematopoietic_system1.57559202
45MP0009840_abnormal_foam_cell1.55316156
46MP0001765_abnormal_ion_homeostasis1.53236260
47MP0006035_abnormal_mitochondrial_morpho1.49638460
48MP0000681_abnormal_thyroid_gland1.47184932
49MP0002876_abnormal_thyroid_physiology1.45656225
50MP0005083_abnormal_biliary_tract1.44726972
51MP0001348_abnormal_lacrimal_gland1.43676876
52MP0000465_gastrointestinal_hemorrhage1.39614645
53MP0008872_abnormal_physiological_respon1.36124644
54MP0004957_abnormal_blastocyst_morpholog1.34544587
55MP0000490_abnormal_crypts_of1.33310692
56MP0005647_abnormal_sex_gland1.32932292
57MP0005646_abnormal_pituitary_gland1.32498991
58MP0008875_abnormal_xenobiotic_pharmacok1.31288797
59MP0002938_white_spotting1.30150321
60MP0010155_abnormal_intestine_physiology1.27909296
61MP0003787_abnormal_imprinting1.26473808
62MP0003866_abnormal_defecation1.26064460
63MP0001881_abnormal_mammary_gland1.24037954
64MP0000579_abnormal_nail_morphology1.23169832
65MP0009780_abnormal_chondrocyte_physiolo1.22609688
66MP0003191_abnormal_cellular_cholesterol1.22353818
67MP0002098_abnormal_vibrissa_morphology1.20436395
68MP0003718_maternal_effect1.18990170
69MP0004381_abnormal_hair_follicle1.18485097
70MP0005501_abnormal_skin_physiology1.17098923
71MP0005174_abnormal_tail_pigmentation1.16543777
72MP0000383_abnormal_hair_follicle1.15344927
73MP0004043_abnormal_pH_regulation1.13307491
74MP0003453_abnormal_keratinocyte_physiol1.11747970
75MP0005381_digestive/alimentary_phenotyp1.10710514
76MP0001216_abnormal_epidermal_layer1.09364290
77MP0004019_abnormal_vitamin_homeostasis1.09007149
78MP0002277_abnormal_respiratory_mucosa1.05309077
79MP0003786_premature_aging1.04676175
80MP0009643_abnormal_urine_homeostasis1.04187686
81MP0000477_abnormal_intestine_morphology1.02379152
82MP0004782_abnormal_surfactant_physiolog1.02163386
83MP0000685_abnormal_immune_system1.02028638
84MP0005636_abnormal_mineral_homeostasis1.00894908
85MP0002693_abnormal_pancreas_physiology1.00523250
86MP0005395_other_phenotype0.99861035
87MP0009333_abnormal_splenocyte_physiolog0.99375617
88MP0008058_abnormal_DNA_repair0.98913591
89MP0000538_abnormal_urinary_bladder0.97801198
90MP0000427_abnormal_hair_cycle0.96663926
91MP0003300_gastrointestinal_ulcer0.96446136
92MP0003315_abnormal_perineum_morphology0.96332661
93MP0001944_abnormal_pancreas_morphology0.96062615
94MP0001730_embryonic_growth_arrest0.95349747
95MP0003183_abnormal_peptide_metabolism0.92915711
96MP0000015_abnormal_ear_pigmentation0.92711565
97MP0003111_abnormal_nucleus_morphology0.92234201
98MP0001666_abnormal_nutrient_absorption0.92042914
99MP0000358_abnormal_cell_content/0.91511649
100MP0000613_abnormal_salivary_gland0.91084404
101MP0003879_abnormal_hair_cell0.89938410
102MP0001968_abnormal_touch/_nociception0.89575466
103MP0005389_reproductive_system_phenotype0.89326468
104MP0002138_abnormal_hepatobiliary_system0.89181654
105MP0001663_abnormal_digestive_system0.89160229
106MP0002009_preneoplasia0.88911208
107MP0002060_abnormal_skin_morphology0.88329402
108MP0005379_endocrine/exocrine_gland_phen0.87229606
109MP0005332_abnormal_amino_acid0.86961888
110MP0004185_abnormal_adipocyte_glucose0.86946447
111MP0006082_CNS_inflammation0.83410986
112MP0002234_abnormal_pharynx_morphology0.83105730
113MP0003252_abnormal_bile_duct0.82555399
114MP0003638_abnormal_response/metabolism_0.82433516
115MP0000627_abnormal_mammary_gland0.82018281
116MP0005275_abnormal_skin_tensile0.81723607
117MP0005464_abnormal_platelet_physiology0.81689070
118MP0005451_abnormal_body_composition0.81040435
119MP0002136_abnormal_kidney_physiology0.80231543
120MP0005058_abnormal_lysosome_morphology0.79513820
121MP0003943_abnormal_hepatobiliary_system0.79077656
122MP0008995_early_reproductive_senescence0.78321245
123MP0001764_abnormal_homeostasis0.78048264
124MP0005076_abnormal_cell_differentiation0.77169114
125MP0008004_abnormal_stomach_pH0.77074368
126MP0005365_abnormal_bile_salt0.75229320
127MP0001756_abnormal_urination0.74802758
128MP0005666_abnormal_adipose_tissue0.74035774
129MP0000470_abnormal_stomach_morphology0.73930435
130MP0008057_abnormal_DNA_replication0.73835815
131MP0005360_urolithiasis0.73167858
132MP0009931_abnormal_skin_appearance0.72625703
133MP0003763_abnormal_thymus_physiology0.72052215
134MP0000003_abnormal_adipose_tissue0.71176692
135MP0003077_abnormal_cell_cycle0.70559247
136MP0003011_delayed_dark_adaptation0.70084306
137MP0004947_skin_inflammation0.70051640
138MP0000377_abnormal_hair_follicle0.68464161
139MP0005380_embryogenesis_phenotype0.68405169
140MP0001672_abnormal_embryogenesis/_devel0.68405169
141MP0003953_abnormal_hormone_level0.67348866
142MP0005670_abnormal_white_adipose0.67274391
143MP0001664_abnormal_digestion0.66992121
144MP0001986_abnormal_taste_sensitivity0.66977304
145MP0003705_abnormal_hypodermis_morpholog0.66062599
146MP0009053_abnormal_anal_canal0.65343996
147MP0009697_abnormal_copulation0.64961014
148MP0002736_abnormal_nociception_after0.64279151
149MP0003115_abnormal_respiratory_system0.64235086
150MP0002118_abnormal_lipid_homeostasis0.63904705
151MP0006072_abnormal_retinal_apoptosis0.63402108
152MP0003936_abnormal_reproductive_system0.62672118
153MP0002132_abnormal_respiratory_system0.62223809
154MP0010094_abnormal_chromosome_stability0.61076895
155MP0010307_abnormal_tumor_latency0.59726217
156MP0002166_altered_tumor_susceptibility0.59409571
157MP0000350_abnormal_cell_proliferation0.58994754
158MP0010771_integument_phenotype0.57187231
159MP0003699_abnormal_female_reproductive0.56230121
160MP0001485_abnormal_pinna_reflex0.55707126
161MP0008007_abnormal_cellular_replicative0.55590015

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.74008357
2Dynein arm defect of respiratory motile cilia (HP:0012255)8.66518613
3Absent/shortened dynein arms (HP:0200106)8.66518613
4Chronic bronchitis (HP:0004469)7.02037412
5Abnormal respiratory motile cilium physiology (HP:0012261)6.52646759
6Abnormal respiratory epithelium morphology (HP:0012253)5.96523517
7Abnormal respiratory motile cilium morphology (HP:0005938)5.96523517
8Nasal polyposis (HP:0100582)5.74610394
9Rhinitis (HP:0012384)5.59866687
10Infertility (HP:0000789)5.41496891
11J-shaped sella turcica (HP:0002680)4.76846585
12Male infertility (HP:0003251)4.76806275
13Abnormality of the nasal mucosa (HP:0000433)4.62983345
14Abnormal ciliary motility (HP:0012262)4.61357234
15Microretrognathia (HP:0000308)4.12421810
16Onycholysis (HP:0001806)4.05373033
17Bronchitis (HP:0012387)3.99302510
18Bronchiectasis (HP:0002110)3.95866651
19Milia (HP:0001056)3.82670312
20Hypoparathyroidism (HP:0000829)3.70031017
21Fragile nails (HP:0001808)3.66557162
22Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.51099820
23Abnormality of calcium-phosphate metabolism (HP:0100530)3.47859809
24Pili torti (HP:0003777)3.46140698
25Abnormal spermatogenesis (HP:0008669)3.41241571
26Right ventricular cardiomyopathy (HP:0011663)3.19380995
27Pustule (HP:0200039)3.16290197
28Hypoplasia of dental enamel (HP:0006297)3.10622479
29Alacrima (HP:0000522)3.01546721
30Abnormality of chloride homeostasis (HP:0011422)3.01462131
31Tubulointerstitial fibrosis (HP:0005576)2.95730395
32Ketoacidosis (HP:0001993)2.95174332
33Vacuolated lymphocytes (HP:0001922)2.85390438
34Abnormality of renal excretion (HP:0011036)2.84549196
35Plantar hyperkeratosis (HP:0007556)2.81863218
36Amelogenesis imperfecta (HP:0000705)2.80293265
37Impulsivity (HP:0100710)2.80257571
38Tubular atrophy (HP:0000092)2.76932404
39Hyperactive renin-angiotensin system (HP:0000841)2.74874274
40Dicarboxylic aciduria (HP:0003215)2.71812340
41Abnormality of dicarboxylic acid metabolism (HP:0010995)2.71812340
42Ketosis (HP:0001946)2.61523296
43Microvesicular hepatic steatosis (HP:0001414)2.60610132
44Azoospermia (HP:0000027)2.56893052
45Hepatic necrosis (HP:0002605)2.56386257
46Hepatocellular necrosis (HP:0001404)2.52311619
47Hypocalcemia (HP:0002901)2.52160529
48Abnormality of renin-angiotensin system (HP:0000847)2.52038454
49Increased circulating renin level (HP:0000848)2.51521476
50Increased IgE level (HP:0003212)2.49439531
51Ileus (HP:0002595)2.45416945
52Nephronophthisis (HP:0000090)2.44816408
53Prostate neoplasm (HP:0100787)2.44286193
54Hyperphosphatemia (HP:0002905)2.42840596
55Dysmetric saccades (HP:0000641)2.38591203
56Atrophic scars (HP:0001075)2.37509032
57Abnormality of small intestinal villus morphology (HP:0011472)2.37032260
58Villous atrophy (HP:0011473)2.37032260
59Decreased lacrimation (HP:0000633)2.35243718
60Metaphyseal irregularity (HP:0003025)2.33958706
61Severe visual impairment (HP:0001141)2.31922668
62Tubulointerstitial abnormality (HP:0001969)2.31057279
63Recurrent otitis media (HP:0000403)2.28564453
64Abnormality of the heme biosynthetic pathway (HP:0010472)2.28421514
65Abnormality of the renal medulla (HP:0100957)2.26823144
66Malnutrition (HP:0004395)2.24172165
67Increased muscle lipid content (HP:0009058)2.23520419
68Hypomagnesemia (HP:0002917)2.23406614
69Conjugated hyperbilirubinemia (HP:0002908)2.23082069
70Hyperthyroidism (HP:0000836)2.23063795
71Abnormal hair laboratory examination (HP:0003328)2.21453374
72Hyperparathyroidism (HP:0000843)2.20598907
73Testicular atrophy (HP:0000029)2.18272085
74Gout (HP:0001997)2.14572531
75Erythema (HP:0010783)2.14424254
76Fatigable weakness (HP:0003473)2.14046666
77Abnormality of the neuromuscular junction (HP:0003398)2.14046666
78Hyperammonemia (HP:0001987)2.10833834
79Hyperglycinuria (HP:0003108)2.10589394
80Tubulointerstitial nephritis (HP:0001970)2.07714138
81Recurrent sinusitis (HP:0011108)2.06796683
82Cerebral palsy (HP:0100021)2.05520086
83Abnormal urine output (HP:0012590)2.04823781
84Tachypnea (HP:0002789)2.00408866
85Acute lymphatic leukemia (HP:0006721)2.00281673
86Nasolacrimal duct obstruction (HP:0000579)1.99977805
87Hyperphosphaturia (HP:0003109)1.98649427
88Increased neuronal autofluorescent lipopigment (HP:0002074)1.98575268
89Recurrent bronchitis (HP:0002837)1.97479242
90Type I transferrin isoform profile (HP:0003642)1.96918691
91Taurodontia (HP:0000679)1.96623946
92Abnormality of permanent molar morphology (HP:0011071)1.96623946
93Abnormality of the dental root (HP:0006486)1.96623946
94Easy fatigability (HP:0003388)1.95630648
95Congenital ichthyosiform erythroderma (HP:0007431)1.93450605
96Increased intramyocellular lipid droplets (HP:0012240)1.93239485
97Mitochondrial inheritance (HP:0001427)1.91863705
98Decreased circulating renin level (HP:0003351)1.91193635
99Abnormality of magnesium homeostasis (HP:0004921)1.90462417
100Deformed sella turcica (HP:0002681)1.90410152
101Nail dystrophy (HP:0008404)1.87876570
102Trismus (HP:0000211)1.87231571
103Tetany (HP:0001281)1.86816518
104Alopecia of scalp (HP:0002293)1.85493657
105Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.84791174
106Abnormal protein N-linked glycosylation (HP:0012347)1.84791174
107Abnormal protein glycosylation (HP:0012346)1.84791174
108Abnormal glycosylation (HP:0012345)1.84791174
109Rectal prolapse (HP:0002035)1.83877126
110Polyuria (HP:0000103)1.83614755
111Abnormality of the prostate (HP:0008775)1.83519708
112Abnormality of the gastric mucosa (HP:0004295)1.83292224
113Lethargy (HP:0001254)1.82866072
114Biliary tract neoplasm (HP:0100574)1.82039260
115Abnormality of the dental pulp (HP:0006479)1.81719836
116Autoimmune hemolytic anemia (HP:0001890)1.81674378
117Metabolic acidosis (HP:0001942)1.81059757
118Metabolic alkalosis (HP:0200114)1.80264354
119Gonadotropin excess (HP:0000837)1.79413697
120Abnormality of aromatic amino acid family metabolism (HP:0004338)1.79150310
121Abnormal drinking behavior (HP:0030082)1.79004776
122Polydipsia (HP:0001959)1.79004776
123Woolly hair (HP:0002224)1.77034177
124Increased CSF lactate (HP:0002490)1.76689890
125Vascular calcification (HP:0004934)1.76602077
126Neoplasm of the adrenal cortex (HP:0100641)1.76579839
127Abnormality of molar morphology (HP:0011070)1.76266747
128Abnormality of molar (HP:0011077)1.76266747
129Hyperuricemia (HP:0002149)1.75778121
130Increased purine levels (HP:0004368)1.75778121
131Flat acetabular roof (HP:0003180)1.75311581
132Cardiomegaly (HP:0001640)1.74998634
133Abnormal urine phosphate concentration (HP:0012599)1.74418711
134Symptomatic seizures (HP:0011145)1.72514216
135Curly hair (HP:0002212)1.69430164
136Abnormality of renal resorption (HP:0011038)1.68917099
137Abnormal rod and cone electroretinograms (HP:0008323)1.68436983
138Ventricular fibrillation (HP:0001663)1.67641264
139Type 2 muscle fiber atrophy (HP:0003554)1.67498344
140Renal salt wasting (HP:0000127)1.67456580
141Gaze-evoked nystagmus (HP:0000640)1.67263239
142Goiter (HP:0000853)1.67144921
143Septate vagina (HP:0001153)1.66854776
144Athetosis (HP:0002305)1.66718068
145Palmoplantar hyperkeratosis (HP:0000972)1.66111816
146Aplasia/Hypoplasia of the spleen (HP:0010451)1.64006221
147Abnormality of endocrine pancreas physiology (HP:0012093)1.63684105
148Abnormality of the pancreatic islet cells (HP:0006476)1.63684105
149Lactic acidosis (HP:0003128)1.63337443
150Abnormality of the distal phalanx of the thumb (HP:0009617)1.62440528
151Hyperinsulinemic hypoglycemia (HP:0000825)1.61945323
152Large for gestational age (HP:0001520)1.59463580
153Impaired proprioception (HP:0010831)1.59362859
154Keratoconjunctivitis (HP:0001096)1.59215811
155Acute encephalopathy (HP:0006846)1.59041723
156Oral leukoplakia (HP:0002745)1.57937357
157Decreased electroretinogram (ERG) amplitude (HP:0000654)1.56520654
158Lipid accumulation in hepatocytes (HP:0006561)1.56211894
159Facial cleft (HP:0002006)1.55191025
160Abnormality of fatty-acid metabolism (HP:0004359)1.54593549
161Postural tremor (HP:0002174)1.53925455
162Abnormality of the renal cortex (HP:0011035)1.53887599
163Abnormality of iron homeostasis (HP:0011031)1.52528044
164Abdominal distention (HP:0003270)1.52210950
165Palmar hyperkeratosis (HP:0010765)1.51667075
166Double outlet right ventricle (HP:0001719)1.51128917
167Congenital malformation of the right heart (HP:0011723)1.51128917
168Cardiovascular calcification (HP:0011915)1.50970061
169Breast carcinoma (HP:0003002)1.50607349
170Abnormal blistering of the skin (HP:0008066)1.50050820
171Death in infancy (HP:0001522)1.49731182
172Asplenia (HP:0001746)1.49134347
173Natal tooth (HP:0000695)1.47551049
174Subcapsular cataract (HP:0000523)1.47041261
175Breast hypoplasia (HP:0003187)1.46987213
176Hypoplastic labia majora (HP:0000059)1.46661213
177Muscle fiber atrophy (HP:0100295)1.45899472
178Stage 5 chronic kidney disease (HP:0003774)1.43715554
179Dehydration (HP:0001944)1.43710644
180Bundle branch block (HP:0011710)1.43331231

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK35.88819130
2PDK45.88819130
3TESK15.75710793
4SCYL24.11775201
5VRK23.98593439
6PDK23.96978044
7PRKD33.34391609
8TAOK33.02189284
9SMG12.92579721
10ICK2.83952363
11MAP4K22.78524312
12PBK2.74438451
13EPHA22.65717202
14NEK22.50812315
15WNK42.48146899
16STK392.44455772
17FRK2.20737303
18LATS12.19888599
19STK38L2.15584069
20NME22.03933726
21LMTK22.00930873
22MST41.93851303
23NME11.80125842
24STK381.76774333
25DYRK31.72615357
26TAF11.70417006
27MAP3K111.62121710
28EEF2K1.55910274
29MAP4K11.54900937
30ACVR1B1.48435663
31STK31.47095853
32TTK1.46394050
33GRK61.41908945
34MAP3K121.41463115
35KIT1.40808494
36DAPK11.36027247
37EIF2AK11.31933786
38PIM21.29850130
39DYRK1B1.24127137
40MAP2K21.17944692
41TNK21.15257684
42BMPR1B1.11693241
43MST1R1.09371878
44PTK2B1.06654769
45HIPK21.04972097
46STK101.04662066
47PTK61.03970016
48TBK11.02623891
49MUSK1.00770447
50TESK20.99104024
51IKBKB0.99047760
52MATK0.94801702
53ZAK0.93017629
54MAP2K60.92802212
55TAOK10.90580146
56SIK10.89249942
57LATS20.88620901
58TRIB30.83732509
59MAPK150.81847065
60GRK10.81799426
61IRAK30.80876588
62PRKD20.80011226
63NUAK10.79425856
64PAK40.78219705
65MAP3K30.77593204
66CHEK20.74607804
67WEE10.74283673
68PAK10.73306188
69VRK10.73247734
70AURKB0.72722745
71NEK60.72144993
72CSF1R0.70661586
73RIPK10.69762758
74CDK190.69382383
75AKT30.68630261
76PRKCI0.68336419
77PINK10.67165101
78MAP3K10.66207925
79PTK20.65424553
80PIK3CA0.62951831
81MAP3K20.62812522
82PLK40.61133511
83MAP2K10.58995501
84PRKG20.58949927
85PDK10.57058033
86RPS6KB20.55550758
87EIF2AK30.55411089
88MAPKAPK30.54897033
89EIF2AK20.54667039
90FER0.54640764
91EPHB20.54263153
92TYRO30.53503422
93RPS6KA40.53480766
94BRSK20.53287237
95CDK70.50088380
96IKBKE0.49595460
97PLK10.48802932
98BUB10.47498873
99OXSR10.47170251
100MAP3K80.46959019
101EPHB10.46536599
102DDR20.46415643
103PKN20.46205560
104KDR0.45642291
105ATR0.45592674
106RPS6KB10.45449840
107CSNK1A10.44660938
108MTOR0.43705259
109MAP3K70.42584646
110CHUK0.41407119
111PASK0.40793599
112BCR0.39368461
113NLK0.39175219
114AKT20.38385571
115MARK30.37739826
116PRKAA10.37653203
117BTK0.37223285
118PAK20.36749585
119PDPK10.36132872
120FLT30.35983678
121WNK30.35923296
122TEC0.34954298
123CHEK10.34106379
124MAP3K100.33363711
125KSR20.33282885
126MAPK30.33043803
127STK160.33000247
128BMX0.31305994
129JAK30.31151282
130FES0.30091490
131RPS6KA10.30077508
132MAPK110.29144008
133CDK40.28966175
134LRRK20.28861758
135CDK120.28638356
136MAP3K140.28426031
137CSNK2A20.28183067
138IRAK20.27896116
139PNCK0.27799285
140WNK10.27604109
141CDC70.27272196
142PRKCD0.27181126
143CDK60.23143676
144ERN10.22850442
145AURKA0.22520259
146MET0.22279092
147CDK90.20948510
148ATM0.20747608
149FGFR40.20579913
150MYLK0.19872458
151CDK30.18895704
152PRKAA20.18225010
153BCKDK0.17397536
154ERBB20.17300943
155MAPKAPK50.16465042
156ERBB40.16150483
157MELK0.15838312
158PIM10.15649577

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007503.41324860
2alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.27452240
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.22201849
4Fatty acid elongation_Homo sapiens_hsa000623.11872054
5Linoleic acid metabolism_Homo sapiens_hsa005913.10234601
6Fatty acid biosynthesis_Homo sapiens_hsa000612.97120837
7Cyanoamino acid metabolism_Homo sapiens_hsa004602.92317451
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.62277830
9Mineral absorption_Homo sapiens_hsa049782.61608495
10Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.55908488
11Sulfur metabolism_Homo sapiens_hsa009202.52879919
12Base excision repair_Homo sapiens_hsa034102.50414366
13Butanoate metabolism_Homo sapiens_hsa006502.41038105
14Fat digestion and absorption_Homo sapiens_hsa049752.17453758
15Pyruvate metabolism_Homo sapiens_hsa006202.16998136
16Peroxisome_Homo sapiens_hsa041462.13226102
17Glutathione metabolism_Homo sapiens_hsa004802.03961049
18Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.98857233
19Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.98116167
20Pentose phosphate pathway_Homo sapiens_hsa000301.92596860
21Basal transcription factors_Homo sapiens_hsa030221.89997536
22Antigen processing and presentation_Homo sapiens_hsa046121.82987609
23Fructose and mannose metabolism_Homo sapiens_hsa000511.77387238
24Selenocompound metabolism_Homo sapiens_hsa004501.76588405
25Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.72679141
26Tight junction_Homo sapiens_hsa045301.62179894
27Glycerolipid metabolism_Homo sapiens_hsa005611.59255736
28Glycerophospholipid metabolism_Homo sapiens_hsa005641.59193786
29Arachidonic acid metabolism_Homo sapiens_hsa005901.58723408
30Nitrogen metabolism_Homo sapiens_hsa009101.53621453
31Primary bile acid biosynthesis_Homo sapiens_hsa001201.53285077
32Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.51840868
33RNA transport_Homo sapiens_hsa030131.50527560
34Propanoate metabolism_Homo sapiens_hsa006401.46127731
35Steroid hormone biosynthesis_Homo sapiens_hsa001401.41061283
36Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.40344869
37DNA replication_Homo sapiens_hsa030301.33945624
38Vitamin digestion and absorption_Homo sapiens_hsa049771.27402152
39Autoimmune thyroid disease_Homo sapiens_hsa053201.24060921
40Tryptophan metabolism_Homo sapiens_hsa003801.23993628
41Ether lipid metabolism_Homo sapiens_hsa005651.23160036
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.21585425
43Protein digestion and absorption_Homo sapiens_hsa049741.21461116
44Carbohydrate digestion and absorption_Homo sapiens_hsa049731.21221886
45Homologous recombination_Homo sapiens_hsa034401.17965016
46Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.17573485
47Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.15954503
48Glucagon signaling pathway_Homo sapiens_hsa049221.13113547
49Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.11975817
50Drug metabolism - other enzymes_Homo sapiens_hsa009831.09050492
51Thyroid hormone synthesis_Homo sapiens_hsa049181.08688500
52Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.07644635
53Folate biosynthesis_Homo sapiens_hsa007901.04359299
54Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.01585668
55Dorso-ventral axis formation_Homo sapiens_hsa043201.01569560
56Histidine metabolism_Homo sapiens_hsa003401.01524276
57Fatty acid degradation_Homo sapiens_hsa000710.99017654
58Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.98052539
59beta-Alanine metabolism_Homo sapiens_hsa004100.97773493
60Glycosaminoglycan degradation_Homo sapiens_hsa005310.95804812
61Adherens junction_Homo sapiens_hsa045200.95501559
62Inositol phosphate metabolism_Homo sapiens_hsa005620.92457200
63PPAR signaling pathway_Homo sapiens_hsa033200.92384527
64One carbon pool by folate_Homo sapiens_hsa006700.92291896
65mRNA surveillance pathway_Homo sapiens_hsa030150.92182547
66Renin-angiotensin system_Homo sapiens_hsa046140.92061043
67Carbon metabolism_Homo sapiens_hsa012000.89356469
68Nucleotide excision repair_Homo sapiens_hsa034200.89304866
69Pancreatic secretion_Homo sapiens_hsa049720.87431009
70Small cell lung cancer_Homo sapiens_hsa052220.86581551
71Ribosome_Homo sapiens_hsa030100.85885586
72Mismatch repair_Homo sapiens_hsa034300.84385227
73Pentose and glucuronate interconversions_Homo sapiens_hsa000400.82716988
74Cell cycle_Homo sapiens_hsa041100.82080059
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.81273979
76Chemical carcinogenesis_Homo sapiens_hsa052040.79940134
77Oocyte meiosis_Homo sapiens_hsa041140.78933525
78Phototransduction_Homo sapiens_hsa047440.78415029
79Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.78381003
80p53 signaling pathway_Homo sapiens_hsa041150.78159483
81Oxidative phosphorylation_Homo sapiens_hsa001900.77829107
82Tyrosine metabolism_Homo sapiens_hsa003500.76339964
83Retinol metabolism_Homo sapiens_hsa008300.75416583
84Bile secretion_Homo sapiens_hsa049760.74367551
85Hippo signaling pathway_Homo sapiens_hsa043900.74105548
86Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.71303504
87Toxoplasmosis_Homo sapiens_hsa051450.70696108
88Legionellosis_Homo sapiens_hsa051340.69418373
89Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.69334930
90Sulfur relay system_Homo sapiens_hsa041220.68089430
91Salivary secretion_Homo sapiens_hsa049700.68059241
92Maturity onset diabetes of the young_Homo sapiens_hsa049500.66942012
93Regulation of autophagy_Homo sapiens_hsa041400.66919064
94Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.66274239
95Influenza A_Homo sapiens_hsa051640.65677464
96Purine metabolism_Homo sapiens_hsa002300.65227427
97Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64806540
98Biosynthesis of amino acids_Homo sapiens_hsa012300.64426078
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.63911375
100Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.63409458
101Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62747675
102SNARE interactions in vesicular transport_Homo sapiens_hsa041300.61922824
103Collecting duct acid secretion_Homo sapiens_hsa049660.60074374
104Sphingolipid metabolism_Homo sapiens_hsa006000.59333514
105Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.58821527
106Fanconi anemia pathway_Homo sapiens_hsa034600.58799717
107Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.57187884
108Lysosome_Homo sapiens_hsa041420.55795777
109Huntingtons disease_Homo sapiens_hsa050160.55301350
110Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54722753
111Basal cell carcinoma_Homo sapiens_hsa052170.54721885
112Pyrimidine metabolism_Homo sapiens_hsa002400.54435361
113Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53771010
114ABC transporters_Homo sapiens_hsa020100.53366069
115Type I diabetes mellitus_Homo sapiens_hsa049400.53039735
116Intestinal immune network for IgA production_Homo sapiens_hsa046720.52597968
117Adipocytokine signaling pathway_Homo sapiens_hsa049200.52163969
118Galactose metabolism_Homo sapiens_hsa000520.49662887
119Bladder cancer_Homo sapiens_hsa052190.49435998
120RNA degradation_Homo sapiens_hsa030180.48819094
121Hedgehog signaling pathway_Homo sapiens_hsa043400.47676513
122Thyroid cancer_Homo sapiens_hsa052160.47102660
123Starch and sucrose metabolism_Homo sapiens_hsa005000.46999078
124Leukocyte transendothelial migration_Homo sapiens_hsa046700.44990371
125Taste transduction_Homo sapiens_hsa047420.44615094
126Olfactory transduction_Homo sapiens_hsa047400.43816269
127Proteasome_Homo sapiens_hsa030500.42282060
128Non-homologous end-joining_Homo sapiens_hsa034500.41521529
129Fatty acid metabolism_Homo sapiens_hsa012120.40796632
130VEGF signaling pathway_Homo sapiens_hsa043700.40763437
131RNA polymerase_Homo sapiens_hsa030200.40044245
132Parkinsons disease_Homo sapiens_hsa050120.39023232
133Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.37971219
134Gastric acid secretion_Homo sapiens_hsa049710.36736283
135Salmonella infection_Homo sapiens_hsa051320.36550943
136Acute myeloid leukemia_Homo sapiens_hsa052210.35473157
137Herpes simplex infection_Homo sapiens_hsa051680.35207757
138Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.34393836
139Arginine and proline metabolism_Homo sapiens_hsa003300.34007866
140Caffeine metabolism_Homo sapiens_hsa002320.33551580
141Metabolic pathways_Homo sapiens_hsa011000.32780277
142ECM-receptor interaction_Homo sapiens_hsa045120.32614168
143AMPK signaling pathway_Homo sapiens_hsa041520.30964536
144Other glycan degradation_Homo sapiens_hsa005110.30899209
145Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.30829132
146Hepatitis C_Homo sapiens_hsa051600.28719639
147Viral carcinogenesis_Homo sapiens_hsa052030.28559328
148Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.27339250
149N-Glycan biosynthesis_Homo sapiens_hsa005100.26807689
150Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.26689398

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