BSCL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the multi-pass transmembrane protein protein seipin. This protein localizes to the endoplasmic reticulum and may be important for lipid droplet morphology. Mutations in this gene have been associated with congenital generalized lipodystrophy type 2 or Berardinelli-Seip syndrome, a rare autosomal recessive disease characterized by a near absence of adipose tissue and severe insulin resistance. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Naturally occurring read-through transcription occurs between this locus and the neighboring locus HNRNPUL2 (heterogeneous nuclear ribonucleoprotein U-like 2). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)6.16459521
2synaptic vesicle maturation (GO:0016188)5.98523870
3acrosome reaction (GO:0007340)5.78630712
4cilium or flagellum-dependent cell motility (GO:0001539)5.38891880
5axonemal dynein complex assembly (GO:0070286)5.23507890
6glutamate secretion (GO:0014047)5.18792876
7piRNA metabolic process (GO:0034587)4.97460182
8multicellular organism reproduction (GO:0032504)4.81587229
9fusion of sperm to egg plasma membrane (GO:0007342)4.74605604
10sperm-egg recognition (GO:0035036)4.65020452
11motile cilium assembly (GO:0044458)4.61993588
12regulation of cilium movement (GO:0003352)4.46205075
13epithelial cilium movement (GO:0003351)4.43019464
14binding of sperm to zona pellucida (GO:0007339)4.20580852
15cell wall macromolecule metabolic process (GO:0044036)4.17529593
16cell wall macromolecule catabolic process (GO:0016998)4.17529593
17plasma membrane fusion (GO:0045026)4.16537974
18acrosome assembly (GO:0001675)4.14937643
19cell-cell recognition (GO:0009988)4.09274991
20calcium ion-dependent exocytosis (GO:0017156)4.08875909
21spermatid development (GO:0007286)4.05069090
22energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.95700561
23ATP hydrolysis coupled proton transport (GO:0015991)3.95700561
24pyrimidine nucleobase catabolic process (GO:0006208)3.84618616
25synaptic vesicle exocytosis (GO:0016079)3.82391560
26cilium movement (GO:0003341)3.79731284
27membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.78359018
28male meiosis (GO:0007140)3.74931640
29reproduction (GO:0000003)3.73808457
30dendritic spine morphogenesis (GO:0060997)3.73551601
31protein localization to cilium (GO:0061512)3.65907493
32transferrin transport (GO:0033572)3.63460967
33gamma-aminobutyric acid transport (GO:0015812)3.57650575
34regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.55674054
35single fertilization (GO:0007338)3.52225913
36organic cation transport (GO:0015695)3.50811223
37neuron cell-cell adhesion (GO:0007158)3.50602405
38auditory behavior (GO:0031223)3.49904214
39positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.48839503
40sperm capacitation (GO:0048240)3.48621687
41ferric iron transport (GO:0015682)3.44834098
42trivalent inorganic cation transport (GO:0072512)3.44834098
43epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.42967343
44neurotransmitter transport (GO:0006836)3.41987134
45regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.40269171
46regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.40269171
47regulation of neurotransmitter levels (GO:0001505)3.38888184
48vocalization behavior (GO:0071625)3.37171897
49synaptic vesicle endocytosis (GO:0048488)3.36416527
50regulation of protein kinase A signaling (GO:0010738)3.35941666
51protein localization to synapse (GO:0035418)3.32514406
52nucleobase catabolic process (GO:0046113)3.30025455
53locomotory exploration behavior (GO:0035641)3.29325638
54chaperone-mediated protein transport (GO:0072321)3.28383081
55transmission of nerve impulse (GO:0019226)3.27347865
56response to pheromone (GO:0019236)3.26262666
57exploration behavior (GO:0035640)3.24959694
58positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.24905573
59regulation of neurotransmitter secretion (GO:0046928)3.22636263
60regulation of neuronal synaptic plasticity (GO:0048168)3.21087539
61neuromuscular synaptic transmission (GO:0007274)3.19610703
62behavioral response to ethanol (GO:0048149)3.16599386
63neuronal ion channel clustering (GO:0045161)3.11721799
64dendritic spine organization (GO:0097061)3.11626818
65positive regulation of neurotransmitter secretion (GO:0001956)3.10168335
66regulation of neurotransmitter transport (GO:0051588)3.09747767
67axonal fasciculation (GO:0007413)3.09548957
68regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.09515037
69cellular potassium ion homeostasis (GO:0030007)3.07940141
70DNA methylation involved in gamete generation (GO:0043046)3.07612189
71positive regulation of neurotransmitter transport (GO:0051590)3.06852076
72glycerol metabolic process (GO:0006071)3.04483101
73positive regulation of mitochondrial fission (GO:0090141)3.03658976
74regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.03132548
75neuron-neuron synaptic transmission (GO:0007270)3.01933735
76regulation of excitatory postsynaptic membrane potential (GO:0060079)3.00255175
77response to auditory stimulus (GO:0010996)2.99569330
78neurotransmitter-gated ion channel clustering (GO:0072578)2.99399398
79gamma-aminobutyric acid signaling pathway (GO:0007214)2.98006451
80synaptic transmission, glutamatergic (GO:0035249)2.96252747
81mitochondrial fission (GO:0000266)2.95884838
82establishment of mitochondrion localization (GO:0051654)2.95071555
83phagosome maturation (GO:0090382)2.95025850
84negative regulation of synaptic transmission, GABAergic (GO:0032229)2.93858212
85presynaptic membrane assembly (GO:0097105)2.93070347
86neurofilament cytoskeleton organization (GO:0060052)2.92448382
87regulation of vesicle fusion (GO:0031338)2.92307434
88establishment of synaptic vesicle localization (GO:0097480)2.89591114
89synaptic vesicle transport (GO:0048489)2.89591114
90regulation of postsynaptic membrane potential (GO:0060078)2.88810109
91lactate metabolic process (GO:0006089)2.86972946
92neurotransmitter secretion (GO:0007269)2.85740154
93dopamine transport (GO:0015872)2.84643315
94regulation of long-term neuronal synaptic plasticity (GO:0048169)2.81211743
95alditol metabolic process (GO:0019400)2.81052043
96regulation of dendritic spine morphogenesis (GO:0061001)2.80637775
97positive regulation of dendritic spine development (GO:0060999)2.79164930
98peroxisome fission (GO:0016559)2.79021044
99neuron recognition (GO:0008038)2.78333592
100protein-cofactor linkage (GO:0018065)2.76988391
101positive regulation of dendritic spine morphogenesis (GO:0061003)2.76936303
102ionotropic glutamate receptor signaling pathway (GO:0035235)2.76358926
103glutamate receptor signaling pathway (GO:0007215)2.74923436
104response to histamine (GO:0034776)2.74853775
105regulation of glutamate receptor signaling pathway (GO:1900449)2.74003093
106membrane depolarization during action potential (GO:0086010)2.73921380
107regulation of voltage-gated calcium channel activity (GO:1901385)2.73210073
108synapse assembly (GO:0007416)2.72954427
109postsynaptic membrane organization (GO:0001941)2.72586773
110regulation of short-term neuronal synaptic plasticity (GO:0048172)2.72223939
111mechanosensory behavior (GO:0007638)2.72185785
112hydrogen ion transmembrane transport (GO:1902600)2.72177150
113fertilization (GO:0009566)2.71889592
114nonmotile primary cilium assembly (GO:0035058)2.71135171
115axoneme assembly (GO:0035082)2.71066385
116regulation of synaptic vesicle exocytosis (GO:2000300)2.71035688
117regulation of synaptic transmission, dopaminergic (GO:0032225)2.70987299
118proline transport (GO:0015824)2.68840946
119response to acidic pH (GO:0010447)2.68268683
120regulation of oxidative phosphorylation (GO:0002082)2.67845983
121sodium ion export (GO:0071436)2.67649248
122synaptic vesicle docking involved in exocytosis (GO:0016081)2.65733841
123G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.65721871
124behavioral response to nicotine (GO:0035095)2.65556442
125acidic amino acid transport (GO:0015800)2.65546841
126spermatogenesis (GO:0007283)2.65051701
127mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.64720821
128synaptic transmission (GO:0007268)2.64287764
129startle response (GO:0001964)2.64008731
130regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.63732551
131male gamete generation (GO:0048232)2.63616033
132presynaptic membrane organization (GO:0097090)2.63598894
133regulation of synaptic vesicle transport (GO:1902803)2.63384802
134regulation of calcium ion-dependent exocytosis (GO:0017158)2.63128281
135phosphatidylglycerol biosynthetic process (GO:0006655)2.62342384
136positive regulation of synaptic transmission, GABAergic (GO:0032230)2.62093556
137positive regulation of membrane potential (GO:0045838)2.62052125
138intraciliary transport (GO:0042073)2.61786913
139establishment of vesicle localization (GO:0051650)2.61181226
140membrane depolarization (GO:0051899)2.59869001
141regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.59734983
142regulation of synaptic transmission, glutamatergic (GO:0051966)2.57741424
143negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.57489555
144neuromuscular process controlling posture (GO:0050884)2.56881883
145negative regulation of inclusion body assembly (GO:0090084)2.56816956
146neuronal action potential propagation (GO:0019227)2.56731182
147oxaloacetate metabolic process (GO:0006107)2.56714355
148regulation of synapse structural plasticity (GO:0051823)2.56589732
149GTP biosynthetic process (GO:0006183)2.56564193
150adult walking behavior (GO:0007628)2.56386149
151detection of light stimulus involved in sensory perception (GO:0050962)2.54336122
152detection of light stimulus involved in visual perception (GO:0050908)2.54336122
153regulation of microtubule-based movement (GO:0060632)2.54227526
154positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.54180831
155glycosphingolipid biosynthetic process (GO:0006688)2.52571182
156positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.52341993

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.47606945
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.15096416
3GBX2_23144817_ChIP-Seq_PC3_Human3.26664888
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.94960482
5MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.83783267
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.54270617
7VDR_22108803_ChIP-Seq_LS180_Human2.46169075
8TAF15_26573619_Chip-Seq_HEK293_Human2.44153842
9REST_21632747_ChIP-Seq_MESCs_Mouse2.36463904
10NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.35583511
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.09574763
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.04336647
13CTBP2_25329375_ChIP-Seq_LNCAP_Human2.03484069
14SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.98613926
15BMI1_23680149_ChIP-Seq_NPCS_Mouse1.86473779
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.86333749
17REST_18959480_ChIP-ChIP_MESCs_Mouse1.84879281
18SUZ12_27294783_Chip-Seq_ESCs_Mouse1.82483385
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.81904003
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.80803693
21RARB_27405468_Chip-Seq_BRAIN_Mouse1.77772966
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.75633583
23FLI1_27457419_Chip-Seq_LIVER_Mouse1.73763383
24JARID2_20064375_ChIP-Seq_MESCs_Mouse1.70662041
25IKZF1_21737484_ChIP-ChIP_HCT116_Human1.68842416
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.67010418
27EZH2_27294783_Chip-Seq_ESCs_Mouse1.63885240
28EZH2_27304074_Chip-Seq_ESCs_Mouse1.63089545
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.62219543
30SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.59005143
31MTF2_20144788_ChIP-Seq_MESCs_Mouse1.57384387
32CBX2_27304074_Chip-Seq_ESCs_Mouse1.55802978
33SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.55222843
34JARID2_20075857_ChIP-Seq_MESCs_Mouse1.54799122
35RNF2_27304074_Chip-Seq_NSC_Mouse1.47940841
36SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.46077493
37SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.41784849
38CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.41541354
39EED_16625203_ChIP-ChIP_MESCs_Mouse1.40377468
40P300_19829295_ChIP-Seq_ESCs_Human1.38629104
41MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.38004216
42HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.37474590
43KDM2B_26808549_Chip-Seq_REH_Human1.34747016
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.33807338
45IGF1R_20145208_ChIP-Seq_DFB_Human1.33527835
46SMAD4_21799915_ChIP-Seq_A2780_Human1.31513073
47SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30634424
48EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.29033084
49TAL1_26923725_Chip-Seq_HPCs_Mouse1.28171161
50MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.26710715
51RNF2_27304074_Chip-Seq_ESCs_Mouse1.26549348
52RNF2_18974828_ChIP-Seq_MESCs_Mouse1.25091983
53EZH2_18974828_ChIP-Seq_MESCs_Mouse1.25091983
54SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.24671450
55FUS_26573619_Chip-Seq_HEK293_Human1.24658649
56PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.24580041
57ZNF274_21170338_ChIP-Seq_K562_Hela1.23740566
58ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.23086728
59AR_25329375_ChIP-Seq_VCAP_Human1.21273849
60NANOG_18555785_Chip-Seq_ESCs_Mouse1.20087353
61TP53_22573176_ChIP-Seq_HFKS_Human1.15412554
62MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.15171287
63CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14746487
64SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14578637
65TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13469654
66IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.13422276
67CBP_20019798_ChIP-Seq_JUKART_Human1.13422276
68LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.13251081
69P53_22387025_ChIP-Seq_ESCs_Mouse1.11911392
70PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.11305154
71KAP1_22055183_ChIP-Seq_ESCs_Mouse1.10871668
72CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.10495789
73SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10175444
74PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.09103388
75GATA1_26923725_Chip-Seq_HPCs_Mouse1.08422174
76OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07276348
77STAT1_17558387_ChIP-Seq_HELA_Human1.07088331
78UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07077747
79TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06926341
80ELK4_26923725_Chip-Seq_MESODERM_Mouse1.06844109
81RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.06619762
82STAT3_18555785_Chip-Seq_ESCs_Mouse1.06159247
83RAD21_21589869_ChIP-Seq_MESCs_Mouse1.06150351
84EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.05482438
85NFE2_27457419_Chip-Seq_LIVER_Mouse1.05246758
86SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.04338052
87CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.04275626
88SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.03267262
89KLF5_20875108_ChIP-Seq_MESCs_Mouse1.02142494
90SMAD3_21741376_ChIP-Seq_EPCs_Human1.01785404
91PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.01721544
92SUZ12_18555785_Chip-Seq_ESCs_Mouse1.01425895
93PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.00134189
94TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.99261209
95GATA3_21867929_ChIP-Seq_TH1_Mouse0.98449570
96EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.98177451
97MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98021314
98MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.97813928
99PIAS1_25552417_ChIP-Seq_VCAP_Human0.97622850
100CMYC_18555785_Chip-Seq_ESCs_Mouse0.97520373
101HTT_18923047_ChIP-ChIP_STHdh_Human0.97213104
102TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97171890
103FLI1_21867929_ChIP-Seq_TH2_Mouse0.97110697
104ER_23166858_ChIP-Seq_MCF-7_Human0.96178798
105DROSHA_22980978_ChIP-Seq_HELA_Human0.96088794
106GATA3_21867929_ChIP-Seq_CD8_Mouse0.96036109
107STAT3_23295773_ChIP-Seq_U87_Human0.95843209
108RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.95167895
109RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.94298690
110CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.94293049
111TCF4_23295773_ChIP-Seq_U87_Human0.94228748
112RUNX1_27457419_Chip-Seq_LIVER_Mouse0.93943130
113TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.93780606
114PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.93698650
115SOX2_18555785_Chip-Seq_ESCs_Mouse0.93621394
116KLF4_18555785_Chip-Seq_ESCs_Mouse0.93336283
117KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.93068359
118SOX2_21211035_ChIP-Seq_LN229_Gbm0.92048341
119FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.91868935
120SOX2_22085726_ChIP-Seq_NPCs_Mouse0.91660761
121E2F1_18555785_Chip-Seq_ESCs_Mouse0.91356122
122NMYC_18555785_Chip-Seq_ESCs_Mouse0.91290811
123P300_18555785_Chip-Seq_ESCs_Mouse0.91137008
124HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.91006196
125ETV2_25802403_ChIP-Seq_MESCs_Mouse0.90642576
126RUNX2_22187159_ChIP-Seq_PCA_Human0.90498307
127ESRRB_18555785_Chip-Seq_ESCs_Mouse0.89550549
128PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.88129406
129GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.87829621
130TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86647704
131POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.86647704
132BCAT_22108803_ChIP-Seq_LS180_Human0.84854809
133NR3C1_23031785_ChIP-Seq_PC12_Mouse0.84071568
134JUN_21703547_ChIP-Seq_K562_Human0.83642134
135TET1_21490601_ChIP-Seq_MESCs_Mouse0.83382811
136EWS_26573619_Chip-Seq_HEK293_Human0.82277180
137NR3C1_21868756_ChIP-Seq_MCF10A_Human0.82062412
138RING1B_27294783_Chip-Seq_ESCs_Mouse0.81518372
139AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.81225171
140NCOR_22424771_ChIP-Seq_293T_Human0.80610222

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization5.21580566
2MP0003880_abnormal_central_pattern3.53379535
3MP0001968_abnormal_touch/_nociception3.14594861
4MP0002876_abnormal_thyroid_physiology3.10964903
5MP0005670_abnormal_white_adipose3.06062259
6MP0002736_abnormal_nociception_after2.92771259
7MP0006276_abnormal_autonomic_nervous2.62855189
8MP0009046_muscle_twitch2.53085816
9MP0003635_abnormal_synaptic_transmissio2.52095918
10MP0005646_abnormal_pituitary_gland2.51793258
11MP0001984_abnormal_olfaction2.50711024
12MP0004859_abnormal_synaptic_plasticity2.37174135
13MP0002638_abnormal_pupillary_reflex2.36363046
14MP0008877_abnormal_DNA_methylation2.35653242
15MP0009745_abnormal_behavioral_response2.32934468
16MP0002735_abnormal_chemical_nociception2.24997220
17MP0001986_abnormal_taste_sensitivity2.17415043
18MP0003698_abnormal_male_reproductive2.16059338
19MP0001501_abnormal_sleep_pattern2.16056174
20MP0002064_seizures2.15936673
21MP0002572_abnormal_emotion/affect_behav2.07891316
22MP0002063_abnormal_learning/memory/cond2.07482668
23MP0001529_abnormal_vocalization1.99380464
24MP0002272_abnormal_nervous_system1.99091537
25MP0003879_abnormal_hair_cell1.96707070
26MP0005645_abnormal_hypothalamus_physiol1.94925773
27MP0000778_abnormal_nervous_system1.84199752
28MP0002734_abnormal_mechanical_nocicepti1.84177049
29MP0001929_abnormal_gametogenesis1.83457927
30MP0010386_abnormal_urinary_bladder1.74677978
31MP0004142_abnormal_muscle_tone1.73879167
32MP0002653_abnormal_ependyma_morphology1.68299459
33MP0002837_dystrophic_cardiac_calcinosis1.67882421
34MP0001905_abnormal_dopamine_level1.66317711
35MP0001188_hyperpigmentation1.64194713
36MP0002067_abnormal_sensory_capabilities1.63552746
37MP0002822_catalepsy1.62638854
38MP0003646_muscle_fatigue1.58964176
39MP0004270_analgesia1.53742577
40MP0001970_abnormal_pain_threshold1.50301609
41MP0002733_abnormal_thermal_nociception1.50110954
42MP0001502_abnormal_circadian_rhythm1.49806865
43MP0004885_abnormal_endolymph1.49621702
44MP0005499_abnormal_olfactory_system1.47483412
45MP0005394_taste/olfaction_phenotype1.47483412
46MP0003787_abnormal_imprinting1.45069611
47MP0002102_abnormal_ear_morphology1.44367948
48MP0005535_abnormal_body_temperature1.43999472
49MP0001486_abnormal_startle_reflex1.37647385
50MP0005551_abnormal_eye_electrophysiolog1.34330503
51MP0008569_lethality_at_weaning1.33633741
52MP0000955_abnormal_spinal_cord1.33268366
53MP0005423_abnormal_somatic_nervous1.32025207
54MP0005451_abnormal_body_composition1.31560863
55MP0003121_genomic_imprinting1.31038094
56MP0004742_abnormal_vestibular_system1.25461225
57MP0001764_abnormal_homeostasis1.23489005
58MP0002161_abnormal_fertility/fecundity1.22517135
59MP0004133_heterotaxia1.21021372
60MP0005379_endocrine/exocrine_gland_phen1.20774475
61MP0003724_increased_susceptibility_to1.20378473
62MP0008789_abnormal_olfactory_epithelium1.19231574
63MP0002557_abnormal_social/conspecific_i1.15434026
64MP0001485_abnormal_pinna_reflex1.15322293
65MP0001440_abnormal_grooming_behavior1.14981026
66MP0006292_abnormal_olfactory_placode1.13666279
67MP0004130_abnormal_muscle_cell1.09922252
68MP0006036_abnormal_mitochondrial_physio1.09503425
69MP0009780_abnormal_chondrocyte_physiolo1.08368421
70MP0008872_abnormal_physiological_respon1.02995717
71MP0002210_abnormal_sex_determination1.02816450
72MP0002184_abnormal_innervation1.02088180
73MP0002152_abnormal_brain_morphology1.01230898
74MP0000013_abnormal_adipose_tissue1.00943038
75MP0002069_abnormal_eating/drinking_beha0.98976131
76MP0003631_nervous_system_phenotype0.96166781
77MP0002752_abnormal_somatic_nervous0.94422805
78MP0004924_abnormal_behavior0.93353483
79MP0005386_behavior/neurological_phenoty0.93353483
80MP0002909_abnormal_adrenal_gland0.91174834
81MP0000026_abnormal_inner_ear0.89520230
82MP0004043_abnormal_pH_regulation0.87751821
83MP0003329_amyloid_beta_deposits0.86188041
84MP0002090_abnormal_vision0.85932121
85MP0005448_abnormal_energy_balance0.85252721
86MP0003191_abnormal_cellular_cholesterol0.82365832
87MP0004811_abnormal_neuron_physiology0.82296893
88MP0009115_abnormal_fat_cell0.81983361
89MP0002066_abnormal_motor_capabilities/c0.81942936
90MP0000653_abnormal_sex_gland0.80295681
91MP0003136_yellow_coat_color0.79446433
92MP0004147_increased_porphyrin_level0.79169812
93MP0005253_abnormal_eye_physiology0.79042030
94MP0003633_abnormal_nervous_system0.77129069
95MP0003011_delayed_dark_adaptation0.77009431
96MP0010329_abnormal_lipoprotein_level0.76922483
97MP0003953_abnormal_hormone_level0.76436949
98MP0001664_abnormal_digestion0.76276806
99MP0008875_abnormal_xenobiotic_pharmacok0.75489549
100MP0005075_abnormal_melanosome_morpholog0.75402450
101MP0001963_abnormal_hearing_physiology0.74482083
102MP0005409_darkened_coat_color0.73598098
103MP0005334_abnormal_fat_pad0.73181699
104MP0009697_abnormal_copulation0.73154021
105MP0002160_abnormal_reproductive_system0.72294290
106MP0000631_abnormal_neuroendocrine_gland0.71613739
107MP0001765_abnormal_ion_homeostasis0.71245363
108MP0002229_neurodegeneration0.70954485
109MP0001145_abnormal_male_reproductive0.70011598
110MP0001177_atelectasis0.68617451
111MP0005666_abnormal_adipose_tissue0.68302106
112MP0004782_abnormal_surfactant_physiolog0.67821462
113MP0006072_abnormal_retinal_apoptosis0.67465020
114MP0005452_abnormal_adipose_tissue0.67121048
115MP0003137_abnormal_impulse_conducting0.66592251
116MP0003122_maternal_imprinting0.66521972
117MP0003959_abnormal_lean_body0.66440966
118MP0002078_abnormal_glucose_homeostasis0.66274786
119MP0002882_abnormal_neuron_morphology0.66177129
120MP0002971_abnormal_brown_adipose0.65127067
121MP0002970_abnormal_white_adipose0.64781991
122MP0005584_abnormal_enzyme/coenzyme_acti0.64181257
123MP0003123_paternal_imprinting0.64142300
124MP0000372_irregular_coat_pigmentation0.61270950
125MP0000566_synostosis0.60349172
126MP0006035_abnormal_mitochondrial_morpho0.59968877
127MP0008995_early_reproductive_senescence0.59882578
128MP0002751_abnormal_autonomic_nervous0.59148557
129MP0003632_abnormal_nervous_system0.59096430
130MP0003634_abnormal_glial_cell0.59033834
131MP0003861_abnormal_nervous_system0.59009010
132MP0003690_abnormal_glial_cell0.58083349

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)6.55379747
2Absent/shortened dynein arms (HP:0200106)6.55379747
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.52084003
4Abnormal respiratory epithelium morphology (HP:0012253)4.90390675
5Abnormal respiratory motile cilium morphology (HP:0005938)4.90390675
6Abnormal respiratory motile cilium physiology (HP:0012261)4.75364883
7Focal motor seizures (HP:0011153)4.37124587
8Oligomenorrhea (HP:0000876)4.34773776
9Infertility (HP:0000789)4.18160919
10Abnormal ciliary motility (HP:0012262)4.02228234
11Abnormal hair whorl (HP:0010721)3.98887509
12Rhinitis (HP:0012384)3.85056672
13Febrile seizures (HP:0002373)3.65715743
14Chronic bronchitis (HP:0004469)3.35413569
15Epileptic encephalopathy (HP:0200134)3.34939128
16Acute necrotizing encephalopathy (HP:0006965)3.32430296
17* Polyphagia (HP:0002591)3.30588551
18Abnormal mitochondria in muscle tissue (HP:0008316)3.18641349
19Hypothermia (HP:0002045)3.15052848
20Cholecystitis (HP:0001082)3.13349011
21Abnormal gallbladder physiology (HP:0012438)3.13349011
22Atonic seizures (HP:0010819)3.11242382
23Action tremor (HP:0002345)3.01622988
24Medial flaring of the eyebrow (HP:0010747)3.00624924
25Nephronophthisis (HP:0000090)2.85662270
26Poor suck (HP:0002033)2.81722306
27Mitochondrial inheritance (HP:0001427)2.77459793
28Nasal polyposis (HP:0100582)2.77099925
29Acute encephalopathy (HP:0006846)2.76355520
30Failure to thrive in infancy (HP:0001531)2.75990375
31Progressive macrocephaly (HP:0004481)2.72977746
32Ankle clonus (HP:0011448)2.70081519
33Mutism (HP:0002300)2.69996618
34Cerebral hypomyelination (HP:0006808)2.69456281
35Hyperventilation (HP:0002883)2.68605379
36Epileptiform EEG discharges (HP:0011182)2.66689706
37Supranuclear gaze palsy (HP:0000605)2.64900102
38Abnormality of the corticospinal tract (HP:0002492)2.63822548
39Optic disc pallor (HP:0000543)2.60616017
40Degeneration of the lateral corticospinal tracts (HP:0002314)2.57486641
41Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.57486641
42EEG with generalized epileptiform discharges (HP:0011198)2.54943266
43Hypsarrhythmia (HP:0002521)2.54407165
44Gait imbalance (HP:0002141)2.54102121
45Bronchiectasis (HP:0002110)2.53972059
46Nephrogenic diabetes insipidus (HP:0009806)2.52166838
47Focal seizures (HP:0007359)2.50968512
48Hepatocellular necrosis (HP:0001404)2.46902592
49* Abnormal eating behavior (HP:0100738)2.46767441
50Congenital primary aphakia (HP:0007707)2.46019265
51Myokymia (HP:0002411)2.43200274
52Focal dystonia (HP:0004373)2.37144814
53Torticollis (HP:0000473)2.35969771
54Increased CSF lactate (HP:0002490)2.35111221
55Progressive cerebellar ataxia (HP:0002073)2.33008381
56Urinary urgency (HP:0000012)2.31953058
57Pancreatic cysts (HP:0001737)2.31565391
58Specific learning disability (HP:0001328)2.27884837
59Recurrent sinusitis (HP:0011108)2.26724262
60Broad-based gait (HP:0002136)2.25199090
61Thyroid-stimulating hormone excess (HP:0002925)2.24065064
62* Spastic gait (HP:0002064)2.23236713
63Urinary bladder sphincter dysfunction (HP:0002839)2.22239522
64Hepatic necrosis (HP:0002605)2.22142711
65Muscular hypotonia of the trunk (HP:0008936)2.21731440
66Vaginal atresia (HP:0000148)2.20684641
67Absence seizures (HP:0002121)2.19447353
68Generalized tonic-clonic seizures (HP:0002069)2.18005230
69Abnormality of the nasal mucosa (HP:0000433)2.17421184
70Bronchitis (HP:0012387)2.17240611
71Status epilepticus (HP:0002133)2.13858370
72CNS hypomyelination (HP:0003429)2.13801843
73Lactic acidosis (HP:0003128)2.13021999
74Anxiety (HP:0000739)2.12760606
75Agitation (HP:0000713)2.11615269
76Intention tremor (HP:0002080)2.11071339
77* Impaired vibration sensation in the lower limbs (HP:0002166)2.10379400
78Craniofacial dystonia (HP:0012179)2.07856162
79Congenital stationary night blindness (HP:0007642)2.06421305
80Spastic tetraplegia (HP:0002510)2.05948162
81Visual hallucinations (HP:0002367)2.05721742
82Abnormality of the labia minora (HP:0012880)2.05562627
83Esotropia (HP:0000565)2.02522115
84Abnormality of the renal medulla (HP:0100957)2.02017220
85Absent speech (HP:0001344)2.01949405
86Sleep apnea (HP:0010535)2.00774602
87Dialeptic seizures (HP:0011146)1.98833537
88Occipital encephalocele (HP:0002085)1.96533222
89Cystic liver disease (HP:0006706)1.96239679
90Morphological abnormality of the pyramidal tract (HP:0002062)1.95702771
91Decreased activity of mitochondrial respiratory chain (HP:0008972)1.94570009
92Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.94570009
93Decreased central vision (HP:0007663)1.92925185
94Drooling (HP:0002307)1.92129542
95Fetal akinesia sequence (HP:0001989)1.89325585
963-Methylglutaconic aciduria (HP:0003535)1.89257777
97Pancreatic fibrosis (HP:0100732)1.89193155
98Aplasia/Hypoplasia of the lens (HP:0008063)1.89058109
99Akinesia (HP:0002304)1.88904915
100Increased muscle lipid content (HP:0009058)1.88730173
101Abnormal spermatogenesis (HP:0008669)1.88165263
102Hemiparesis (HP:0001269)1.87603594
103Abnormality of binocular vision (HP:0011514)1.85930008
104Diplopia (HP:0000651)1.85930008
105Lissencephaly (HP:0001339)1.84833111
106Abnormality of midbrain morphology (HP:0002418)1.84151749
107Molar tooth sign on MRI (HP:0002419)1.84151749
108Progressive inability to walk (HP:0002505)1.83941543
109Postural instability (HP:0002172)1.82800769
110Amyotrophic lateral sclerosis (HP:0007354)1.82483329
111Decreased muscle mass (HP:0003199)1.82070141
112Severe visual impairment (HP:0001141)1.81239823
113Tubulointerstitial nephritis (HP:0001970)1.81096161
114Gonadotropin excess (HP:0000837)1.80705134
115Type II lissencephaly (HP:0007260)1.80511438
116Poor coordination (HP:0002370)1.79520161
117Atrophy/Degeneration involving motor neurons (HP:0007373)1.79225536
118Type 2 muscle fiber atrophy (HP:0003554)1.78111809
119Abnormality of macular pigmentation (HP:0008002)1.77809856
120Limb dystonia (HP:0002451)1.77753568
121Bradykinesia (HP:0002067)1.76623531
122Short tibia (HP:0005736)1.76233812
123Abnormality of the lower motor neuron (HP:0002366)1.75118065
124Pachygyria (HP:0001302)1.74751182
125Male infertility (HP:0003251)1.74635903
126Delusions (HP:0000746)1.74424531
127True hermaphroditism (HP:0010459)1.74041086
128Central scotoma (HP:0000603)1.73743198
129Retinal dysplasia (HP:0007973)1.70428563
130Gaze-evoked nystagmus (HP:0000640)1.70416289
131Cerebral edema (HP:0002181)1.70389651
132Aplasia/Hypoplasia of the tibia (HP:0005772)1.70237783
133Exercise intolerance (HP:0003546)1.70085307
134Azoospermia (HP:0000027)1.67217513
135Leukodystrophy (HP:0002415)1.66111056
136Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.65421438
137Hyperthyroidism (HP:0000836)1.65409764
138Tubulointerstitial abnormality (HP:0001969)1.65405496
139Abnormal rod and cone electroretinograms (HP:0008323)1.64717276
140Abnormality of alanine metabolism (HP:0010916)1.64667731
141Hyperalaninemia (HP:0003348)1.64667731
142Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.64667731
143Postaxial foot polydactyly (HP:0001830)1.63019371
144Brushfield spots (HP:0001088)1.62501147
145Genital tract atresia (HP:0001827)1.61988274
146Amblyopia (HP:0000646)1.61293700
147Chronic sinusitis (HP:0011109)1.61080216

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK34.03066128
2PDK44.03066128
3CASK3.96028019
4MAP3K123.07312980
5MAP2K73.01619889
6MAP4K23.00134267
7MAP3K42.51533913
8PDK22.42809021
9BMPR22.41875006
10CAMKK22.33341629
11CAMK1D2.22660802
12ARAF2.12073091
13NTRK32.10880191
14CDK192.09812989
15UHMK12.07672408
16CAMK1G2.00318196
17TRIM281.95938158
18NTRK21.93960818
19TESK11.90843866
20STK161.85850452
21NME11.77570751
22PRKD31.74916019
23EPHA41.72397594
24CSNK1G21.70595727
25RIPK41.66701208
26PAK31.62897213
27BCR1.61328714
28DAPK11.59234407
29CCNB11.58721243
30BRAF1.54292044
31DAPK21.51686158
32CSNK1G31.50391768
33LIMK11.50386834
34PHKG11.50381824
35PHKG21.50381824
36TNIK1.49947618
37GRK51.42053015
38MAP3K61.41700678
39MAP2K41.40060108
40ADRBK21.32809824
41TNK21.32756427
42CSNK1G11.24698745
43PTK2B1.22771741
44CSNK1A1L1.22416528
45FES1.20043112
46NTRK11.18773677
47MAPK131.13979072
48MAP3K91.13096139
49MUSK1.10923308
50MINK11.09658151
51WNK41.08409208
52KIT1.07454955
53WNK31.04583662
54CAMK11.03042811
55TEC1.02188481
56MAPK151.02187034
57IRAK21.01321311
58BCKDK1.01090641
59CDK141.00155692
60PLK20.97935064
61PRKCG0.92884998
62PRPF4B0.91818038
63LMTK20.89815906
64CAMKK10.87406748
65MYLK0.87379536
66SIK30.86580649
67MARK10.86271558
68STK380.86024762
69FRK0.85898579
70PIM20.85236111
71GRK70.83922349
72EPHA30.82390960
73ERBB30.80243604
74MAP3K130.79294120
75PKN10.76762096
76ADRBK10.76374959
77TXK0.73557788
78DYRK1B0.70736363
79GRK10.69534134
80CAMK2A0.68633061
81SGK2230.66341958
82SGK4940.66341958
83PINK10.64894053
84SIK20.62627487
85CDK30.62498231
86INSRR0.62038026
87BRSK10.61945673
88DYRK30.60757333
89BMPR1B0.60585524
90SYK0.58378130
91CDK50.57874820
92OXSR10.57550997
93MOS0.56307446
94STK38L0.56046765
95AKT30.54648259
96CAMK2D0.54143608
97TAOK30.53041236
98MAP2K60.52484732
99DYRK1A0.51933739
100SGK20.50646698
101PRKCZ0.49750498
102PDK10.49235697
103FER0.48090632
104IRAK10.46013782
105DAPK30.43236225
106KSR10.41703968
107PRKCI0.41017999
108CSNK1A10.40839875
109CAMK2G0.40075914
110PRKCE0.37854698
111RAF10.37683605
112PRKG10.37549113
113PRKACA0.37507220
114BTK0.37500011
115STK110.37210801
116ZAP700.36550213
117PNCK0.36317346
118PDPK10.36147681
119MAP3K50.35941857
120NEK60.35699302
121MAP3K110.35261987
122TYRO30.35168997
123PRKCH0.34942128
124MAPKAPK50.33725674
125ERBB20.33672452
126EIF2AK20.32255301
127CSNK1E0.31862723
128AURKA0.31533863
129CAMK2B0.30302805
130CDK180.30007264
131PAK60.29556704
132TSSK60.28361416
133DYRK20.26563807
134PRKCA0.26559008
135RPS6KA20.26541720
136CDK150.25759530
137MAP3K10.25326177
138CDK11A0.24280921
139CAMK40.24117034
140YES10.24036317
141CDK80.23996945
142IKBKE0.23532456

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.87891859
2Synaptic vesicle cycle_Homo sapiens_hsa047213.74785518
3Collecting duct acid secretion_Homo sapiens_hsa049663.56139997
4Oxidative phosphorylation_Homo sapiens_hsa001903.27506585
5Pyruvate metabolism_Homo sapiens_hsa006202.75747929
6Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.45394592
7Parkinsons disease_Homo sapiens_hsa050122.31609996
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.18489666
9Propanoate metabolism_Homo sapiens_hsa006402.14694068
10Morphine addiction_Homo sapiens_hsa050322.10325573
11Huntingtons disease_Homo sapiens_hsa050162.10309170
12Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.08090439
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.98856720
14Fatty acid biosynthesis_Homo sapiens_hsa000611.98738471
15GABAergic synapse_Homo sapiens_hsa047271.93856264
16Alzheimers disease_Homo sapiens_hsa050101.93380276
17Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.68050862
18Circadian entrainment_Homo sapiens_hsa047131.68034931
19Amphetamine addiction_Homo sapiens_hsa050311.65031386
20Taste transduction_Homo sapiens_hsa047421.63477399
21Steroid biosynthesis_Homo sapiens_hsa001001.60122540
22Vibrio cholerae infection_Homo sapiens_hsa051101.58164675
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.54031727
24Olfactory transduction_Homo sapiens_hsa047401.48518076
25Glutamatergic synapse_Homo sapiens_hsa047241.45026827
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.43798730
27Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.42749057
28Cardiac muscle contraction_Homo sapiens_hsa042601.33970636
29Dopaminergic synapse_Homo sapiens_hsa047281.33047254
30Glycerolipid metabolism_Homo sapiens_hsa005611.30966823
31Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.29512424
32Insulin secretion_Homo sapiens_hsa049111.23735316
33Serotonergic synapse_Homo sapiens_hsa047261.23098950
34Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.23031447
35Renin secretion_Homo sapiens_hsa049241.21477517
36Rheumatoid arthritis_Homo sapiens_hsa053231.21450879
37Calcium signaling pathway_Homo sapiens_hsa040201.21375029
38PPAR signaling pathway_Homo sapiens_hsa033201.20520993
39Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.18415676
40Salivary secretion_Homo sapiens_hsa049701.13380544
41Fatty acid metabolism_Homo sapiens_hsa012121.11985351
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.10295329
43Long-term potentiation_Homo sapiens_hsa047201.09802704
44Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.09398412
45Proteasome_Homo sapiens_hsa030501.04824973
46Linoleic acid metabolism_Homo sapiens_hsa005911.04318484
47Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.02705396
48alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.02410694
49Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.01318819
50Fatty acid elongation_Homo sapiens_hsa000620.98408291
51Peroxisome_Homo sapiens_hsa041460.96530075
52Cocaine addiction_Homo sapiens_hsa050300.93719922
53beta-Alanine metabolism_Homo sapiens_hsa004100.93202374
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.93041562
55SNARE interactions in vesicular transport_Homo sapiens_hsa041300.90495500
56Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.88071752
57Cholinergic synapse_Homo sapiens_hsa047250.87660947
58Glucagon signaling pathway_Homo sapiens_hsa049220.83669261
59Phagosome_Homo sapiens_hsa041450.79293070
60Fructose and mannose metabolism_Homo sapiens_hsa000510.77940351
61Glycerophospholipid metabolism_Homo sapiens_hsa005640.74718725
62Vitamin B6 metabolism_Homo sapiens_hsa007500.74538243
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73775014
64Phenylalanine metabolism_Homo sapiens_hsa003600.72279423
65Other glycan degradation_Homo sapiens_hsa005110.71984611
66Regulation of autophagy_Homo sapiens_hsa041400.70915872
67Arginine and proline metabolism_Homo sapiens_hsa003300.70581236
68Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.70476654
69Carbon metabolism_Homo sapiens_hsa012000.69866557
70Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.69204676
71Axon guidance_Homo sapiens_hsa043600.67994306
72Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.67677122
73Folate biosynthesis_Homo sapiens_hsa007900.67629510
74Aldosterone synthesis and secretion_Homo sapiens_hsa049250.65843508
75Primary bile acid biosynthesis_Homo sapiens_hsa001200.65760934
76Type I diabetes mellitus_Homo sapiens_hsa049400.63131731
77Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.62504724
78Gap junction_Homo sapiens_hsa045400.62062390
79Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.60099815
80Fatty acid degradation_Homo sapiens_hsa000710.57262708
81Pentose phosphate pathway_Homo sapiens_hsa000300.56779863
82cAMP signaling pathway_Homo sapiens_hsa040240.56668559
83Metabolic pathways_Homo sapiens_hsa011000.55416616
84Sulfur relay system_Homo sapiens_hsa041220.55080449
85Ether lipid metabolism_Homo sapiens_hsa005650.54746666
86Arachidonic acid metabolism_Homo sapiens_hsa005900.54309112
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53762010
88Maturity onset diabetes of the young_Homo sapiens_hsa049500.53476948
89Alcoholism_Homo sapiens_hsa050340.52860797
90Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.52819560
91Nitrogen metabolism_Homo sapiens_hsa009100.52443700
92Oxytocin signaling pathway_Homo sapiens_hsa049210.51903688
93Long-term depression_Homo sapiens_hsa047300.50926082
94Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50520331
95Phototransduction_Homo sapiens_hsa047440.49584273
96Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.48996579
97Cysteine and methionine metabolism_Homo sapiens_hsa002700.48905593
98ABC transporters_Homo sapiens_hsa020100.47758546
99Sphingolipid metabolism_Homo sapiens_hsa006000.47112011
100Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46955836
101Asthma_Homo sapiens_hsa053100.45866905
1022-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.45322985
103Protein export_Homo sapiens_hsa030600.42929734
104Gastric acid secretion_Homo sapiens_hsa049710.42221634
105Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.40348819
106Pancreatic secretion_Homo sapiens_hsa049720.40100080
107Tyrosine metabolism_Homo sapiens_hsa003500.39740523
108Butanoate metabolism_Homo sapiens_hsa006500.39475455
109Purine metabolism_Homo sapiens_hsa002300.38459542
110RNA polymerase_Homo sapiens_hsa030200.38175712
111Glycosaminoglycan degradation_Homo sapiens_hsa005310.37884681
112Melanogenesis_Homo sapiens_hsa049160.36931702
113Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.33966620
114Vascular smooth muscle contraction_Homo sapiens_hsa042700.32572378
115Autoimmune thyroid disease_Homo sapiens_hsa053200.32540830
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31033075
117Oocyte meiosis_Homo sapiens_hsa041140.30913260
118Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.30352885
119Bile secretion_Homo sapiens_hsa049760.29984970
120Histidine metabolism_Homo sapiens_hsa003400.29252413
121Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.29048257
122Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.28868212
123Glutathione metabolism_Homo sapiens_hsa004800.28489184
124Thyroid hormone synthesis_Homo sapiens_hsa049180.27997012
125cGMP-PKG signaling pathway_Homo sapiens_hsa040220.27885012
126Fat digestion and absorption_Homo sapiens_hsa049750.27654671
127Carbohydrate digestion and absorption_Homo sapiens_hsa049730.26341246
128Circadian rhythm_Homo sapiens_hsa047100.23569875

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