BRS3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a G protein-coupled membrane receptor that binds bombesin-like peptides. This binding results in activation of a phosphatidylinositol-calcium second messenger system, with physiological effects including regulation of metabolic rate, glucose metabolism, and hypertension. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cAMP-mediated signaling (GO:0043951)9.63077435
2ether lipid metabolic process (GO:0046485)7.98685190
3adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)6.80873452
4regulation of acrosome reaction (GO:0060046)6.51310818
5regulation of short-term neuronal synaptic plasticity (GO:0048172)6.43071584
6regulation of protein glycosylation (GO:0060049)6.40599589
7regulation of translational termination (GO:0006449)5.94567667
8positive regulation of cAMP-mediated signaling (GO:0043950)5.45135382
9piRNA metabolic process (GO:0034587)5.40530353
10developmental pigmentation (GO:0048066)5.29917199
11negative regulation of glycoprotein biosynthetic process (GO:0010561)5.21784822
12sphingosine metabolic process (GO:0006670)5.20200928
13negative regulation of nitric oxide biosynthetic process (GO:0045019)4.76374348
14tyrosine metabolic process (GO:0006570)4.73453222
15diol metabolic process (GO:0034311)4.62107298
16opioid receptor signaling pathway (GO:0038003)4.54913774
17glycerol ether metabolic process (GO:0006662)4.41221142
18phenol-containing compound biosynthetic process (GO:0046189)4.36950684
19sphingoid metabolic process (GO:0046519)4.36071962
20regulation of protein kinase A signaling (GO:0010738)4.29675382
21ether metabolic process (GO:0018904)4.28124370
22vocalization behavior (GO:0071625)4.22939394
23cornea development in camera-type eye (GO:0061303)4.17988098
24response to histamine (GO:0034776)4.12169292
25regulation of ER to Golgi vesicle-mediated transport (GO:0060628)4.10798465
26secondary metabolic process (GO:0019748)4.07646824
27negative regulation of synaptic transmission, GABAergic (GO:0032229)4.02654368
28neuron recognition (GO:0008038)4.01982147
29positive regulation of synaptic transmission, GABAergic (GO:0032230)4.01795005
30mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.96340925
31synaptic vesicle maturation (GO:0016188)3.94387376
32regulation of cAMP-mediated signaling (GO:0043949)3.91717499
33thrombin receptor signaling pathway (GO:0070493)3.91199777
34transmission of nerve impulse (GO:0019226)3.84339126
35gamma-aminobutyric acid signaling pathway (GO:0007214)3.84152271
36peptide hormone processing (GO:0016486)3.80856596
37energy coupled proton transport, down electrochemical gradient (GO:0015985)3.80490010
38ATP synthesis coupled proton transport (GO:0015986)3.80490010
39negative regulation of glycoprotein metabolic process (GO:1903019)3.75791629
40behavioral fear response (GO:0001662)3.73232654
41behavioral defense response (GO:0002209)3.73232654
42pyrimidine dimer repair (GO:0006290)3.72536021
43mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.68335563
44regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.67400234
45regulation of glutamate receptor signaling pathway (GO:1900449)3.67313231
46fear response (GO:0042596)3.66572329
47locomotory exploration behavior (GO:0035641)3.63950510
48positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.63324326
49positive regulation of synapse assembly (GO:0051965)3.61483996
50glycerophospholipid catabolic process (GO:0046475)3.59714362
51cellular ketone body metabolic process (GO:0046950)3.58733896
52synaptic vesicle exocytosis (GO:0016079)3.54744035
53regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.54495893
54striatum development (GO:0021756)3.53289240
55ketone body metabolic process (GO:1902224)3.51236720
56neuron cell-cell adhesion (GO:0007158)3.49672174
57neuronal action potential (GO:0019228)3.48776303
58ionotropic glutamate receptor signaling pathway (GO:0035235)3.46372615
59protein localization to synapse (GO:0035418)3.43445211
60glycosphingolipid metabolic process (GO:0006687)3.42078364
61neurotransmitter secretion (GO:0007269)3.41674898
62mating behavior (GO:0007617)3.40495748
63glutamate receptor signaling pathway (GO:0007215)3.35393157
64regulation of vesicle fusion (GO:0031338)3.31681537
65layer formation in cerebral cortex (GO:0021819)3.28392467
66negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.27304864
67preassembly of GPI anchor in ER membrane (GO:0016254)3.27075075
68negative regulation of norepinephrine secretion (GO:0010700)3.25729145
69regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.25630554
70glutamate secretion (GO:0014047)3.25186457
71regulation of memory T cell differentiation (GO:0043380)3.24460307
72neuronal action potential propagation (GO:0019227)3.22747238
73presynaptic membrane assembly (GO:0097105)3.21224010
74detection of calcium ion (GO:0005513)3.20901974
75DNA replication-dependent nucleosome organization (GO:0034723)3.20758536
76DNA replication-dependent nucleosome assembly (GO:0006335)3.20758536
77energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.19129384
78ATP hydrolysis coupled proton transport (GO:0015991)3.19129384
79coenzyme catabolic process (GO:0009109)3.18334621
80proline transport (GO:0015824)3.17985404
81epithelial cell fate commitment (GO:0072148)3.17580801
82neurotransmitter transport (GO:0006836)3.15867539
83regulation of synaptic vesicle exocytosis (GO:2000300)3.12884827
84dendritic spine morphogenesis (GO:0060997)3.12746125
85peptidyl-arginine omega-N-methylation (GO:0035247)3.11429973
86regulation of excitatory postsynaptic membrane potential (GO:0060079)3.11413133
87G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.10962533
88water-soluble vitamin biosynthetic process (GO:0042364)3.10789395
89nodal signaling pathway (GO:0038092)3.09423182
90regulation of synaptic transmission, GABAergic (GO:0032228)3.09203359
91glomerular visceral epithelial cell development (GO:0072015)3.07982048
92membrane depolarization during action potential (GO:0086010)3.06447741
93positive regulation of gluconeogenesis (GO:0045722)3.05760962
94cellular response to ammonium ion (GO:0071242)3.05451539
95positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.04971462
96presynaptic membrane organization (GO:0097090)3.04404066
97cellular response to alkaloid (GO:0071312)3.01328375
98regulation of calcium ion-dependent exocytosis (GO:0017158)3.00117692
99respiratory electron transport chain (GO:0022904)2.99813461
100behavioral response to ethanol (GO:0048149)2.99588148
101regulation of postsynaptic membrane potential (GO:0060078)2.97875323
102electron transport chain (GO:0022900)2.97172999
103activation of protein kinase A activity (GO:0034199)2.96613399
104negative regulation of cell-matrix adhesion (GO:0001953)2.94756785
105glycolipid metabolic process (GO:0006664)2.94210156
106negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.93322114
107epithelial cilium movement (GO:0003351)2.92557856
108regulation of female receptivity (GO:0045924)2.91156352
109calcium ion import (GO:0070509)2.91031407
110regulation of cAMP-dependent protein kinase activity (GO:2000479)2.90806289
111regulation of neurotransmitter uptake (GO:0051580)2.89944921
112negative regulation of execution phase of apoptosis (GO:1900118)2.89093056
113signal peptide processing (GO:0006465)2.88929005
114thyroid hormone metabolic process (GO:0042403)2.88538218
115negative regulation of adenylate cyclase activity (GO:0007194)2.88384896
116positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.87976259
117membrane depolarization (GO:0051899)2.86449242
118suckling behavior (GO:0001967)2.86302871
119neuronal ion channel clustering (GO:0045161)2.86229233
120regulation of long-term neuronal synaptic plasticity (GO:0048169)2.86078355
121short-term memory (GO:0007614)2.85611480
122notochord development (GO:0030903)2.85570898
123axonal fasciculation (GO:0007413)2.84892248
124mRNA cleavage (GO:0006379)2.84703054
125regulation of neurotransmitter levels (GO:0001505)2.84601071
126long-chain fatty acid biosynthetic process (GO:0042759)2.83785791
127regulation of appetite (GO:0032098)2.83210833
128signal complex assembly (GO:0007172)2.83027809
129* adult feeding behavior (GO:0008343)2.82849759
130negative regulation of lyase activity (GO:0051350)2.82736802
131ncRNA catabolic process (GO:0034661)2.82552852
132positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.82308319
133dopamine transport (GO:0015872)2.81585870
134glycosphingolipid biosynthetic process (GO:0006688)2.81559526
135neuron-neuron synaptic transmission (GO:0007270)2.81033328
136establishment of protein localization to mitochondrial membrane (GO:0090151)2.80726934
137regulation of neuronal synaptic plasticity (GO:0048168)2.80195791
138heart field specification (GO:0003128)2.79022268
139secondary heart field specification (GO:0003139)2.79022268
140membrane lipid metabolic process (GO:0006643)2.78723078
141exploration behavior (GO:0035640)2.78205264
142pigment biosynthetic process (GO:0046148)2.77693906
143adaptation of signaling pathway (GO:0023058)2.77368047
144transferrin transport (GO:0033572)2.76438542
145vesicle transport along microtubule (GO:0047496)2.75199557
146regulation of synapse assembly (GO:0051963)2.74318707
147negative regulation of cyclase activity (GO:0031280)2.72862307
148thyroid hormone generation (GO:0006590)2.72757000
149fat-soluble vitamin catabolic process (GO:0042363)2.72310667
150vitamin catabolic process (GO:0009111)2.72310667
151neuromuscular process controlling posture (GO:0050884)2.71842173
152regulation of translational elongation (GO:0006448)2.71714591
153retinal rod cell development (GO:0046548)2.70630747
154peptidyl-arginine N-methylation (GO:0035246)2.70125735
155peptidyl-arginine methylation (GO:0018216)2.70125735
156angiotensin maturation (GO:0002003)2.69485905
157regulation of uterine smooth muscle contraction (GO:0070472)2.69247571
158L-glutamate transport (GO:0015813)2.67919471
159synaptic transmission, glutamatergic (GO:0035249)2.67845504
160glomerular epithelial cell development (GO:0072310)2.66349102
161positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)2.66106863
162liposaccharide metabolic process (GO:1903509)2.65432772
163negative regulation of exocytosis (GO:0045920)2.64955147
164dendrite development (GO:0016358)2.64937907
165acidic amino acid transport (GO:0015800)2.63353744
166protein K11-linked deubiquitination (GO:0035871)2.61709628
167glycine transport (GO:0015816)2.59360788
168regulation of feeding behavior (GO:0060259)2.59296616
169trivalent inorganic cation transport (GO:0072512)2.58899503
170ferric iron transport (GO:0015682)2.58899503
171innervation (GO:0060384)2.57969092
172positive regulation of protein complex disassembly (GO:0043243)2.55697593
173GPI anchor metabolic process (GO:0006505)2.53678712
174negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.52331521
175sphingolipid metabolic process (GO:0006665)2.51262458
176positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.51049619
177cardiac right ventricle morphogenesis (GO:0003215)2.50752238
178positive regulation of fatty acid transport (GO:2000193)2.49402275
179polyol biosynthetic process (GO:0046173)2.48240334
180regulation of secondary heart field cardioblast proliferation (GO:0003266)2.46789914
181regulation of cardioblast proliferation (GO:0003264)2.46789914
182response to dietary excess (GO:0002021)2.46285672
183left/right axis specification (GO:0070986)2.45357809
184regulation of rhodopsin mediated signaling pathway (GO:0022400)2.45150719
185melanin biosynthetic process (GO:0042438)12.8649159
186negative regulation of cytosolic calcium ion concentration (GO:0051481)12.0608092
187melanin metabolic process (GO:0006582)11.5664662
188secondary metabolite biosynthetic process (GO:0044550)10.5492737

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.17234906
2JARID2_20064375_ChIP-Seq_MESCs_Mouse3.10808037
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.04799819
4GBX2_23144817_ChIP-Seq_PC3_Human3.01572810
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.90381106
6TAF15_26573619_Chip-Seq_HEK293_Human2.89864188
7SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.77044320
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.71372784
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.67037187
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.67037187
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.53640954
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.52064541
13CTBP1_25329375_ChIP-Seq_LNCAP_Human2.51292649
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.45842208
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.40673009
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.40468390
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.39946418
18NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.39109116
19IGF1R_20145208_ChIP-Seq_DFB_Human2.36771491
20AR_21572438_ChIP-Seq_LNCaP_Human2.35281444
21SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.31668917
22PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.29925338
23REST_21632747_ChIP-Seq_MESCs_Mouse2.26065629
24FLI1_27457419_Chip-Seq_LIVER_Mouse2.22617118
25BMI1_23680149_ChIP-Seq_NPCS_Mouse2.12469059
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.10853790
27EZH2_27294783_Chip-Seq_ESCs_Mouse2.09264980
28IKZF1_21737484_ChIP-ChIP_HCT116_Human2.06597974
29TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.05160234
30POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.05160234
31RNF2_27304074_Chip-Seq_ESCs_Mouse2.01504097
32SUZ12_27294783_Chip-Seq_ESCs_Mouse1.97458877
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.97394785
34P300_19829295_ChIP-Seq_ESCs_Human1.96659070
35SUZ12_27294783_Chip-Seq_NPCs_Mouse1.84553997
36PIAS1_25552417_ChIP-Seq_VCAP_Human1.83312661
37FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.79311786
38REST_18959480_ChIP-ChIP_MESCs_Mouse1.77910600
39CDX2_19796622_ChIP-Seq_MESCs_Mouse1.77173022
40SMAD4_21799915_ChIP-Seq_A2780_Human1.72409506
41POU3F2_20337985_ChIP-ChIP_501MEL_Human1.71921458
42RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.70711957
43ZNF274_21170338_ChIP-Seq_K562_Hela1.67035055
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65421437
45NFE2_27457419_Chip-Seq_LIVER_Mouse1.64271285
46DROSHA_22980978_ChIP-Seq_HELA_Human1.61955830
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.61352516
48PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.59124885
49RARB_27405468_Chip-Seq_BRAIN_Mouse1.59003103
50RNF2_27304074_Chip-Seq_NSC_Mouse1.58168550
51CBP_20019798_ChIP-Seq_JUKART_Human1.58045803
52IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.58045803
53BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.56827218
54NANOG_19829295_ChIP-Seq_ESCs_Human1.55591208
55SOX2_19829295_ChIP-Seq_ESCs_Human1.55591208
56GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.50232479
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.49718631
58EZH2_27294783_Chip-Seq_NPCs_Mouse1.49670829
59AR_25329375_ChIP-Seq_VCAP_Human1.49163431
60SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45093925
61OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43801472
62ER_23166858_ChIP-Seq_MCF-7_Human1.41309892
63SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40189352
64CDX2_22108803_ChIP-Seq_LS180_Human1.37102303
65TRIM28_21343339_ChIP-Seq_HEK293_Human1.36878773
66MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.36555708
67TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35943267
68HTT_18923047_ChIP-ChIP_STHdh_Human1.32513541
69SMAD_19615063_ChIP-ChIP_OVARY_Human1.31695623
70PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30978712
71EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.30962631
72TAL1_26923725_Chip-Seq_HPCs_Mouse1.30469343
73FLI1_21867929_ChIP-Seq_TH2_Mouse1.29934940
74CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.28624456
75NR3C1_21868756_ChIP-Seq_MCF10A_Human1.28190817
76TP53_22573176_ChIP-Seq_HFKS_Human1.26538510
77TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26227932
78FUS_26573619_Chip-Seq_HEK293_Human1.26087314
79ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.26075262
80MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.25678873
81EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.25315531
82SOX2_21211035_ChIP-Seq_LN229_Gbm1.23943673
83RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22058218
84CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.18398744
85SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.17956527
86RUNX2_22187159_ChIP-Seq_PCA_Human1.17587727
87ETV2_25802403_ChIP-Seq_MESCs_Mouse1.17499941
88CRX_20693478_ChIP-Seq_RETINA_Mouse1.17424525
89UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16264370
90TCF4_22108803_ChIP-Seq_LS180_Human1.14434284
91VDR_22108803_ChIP-Seq_LS180_Human1.10968532
92JUN_21703547_ChIP-Seq_K562_Human1.10831511
93FOXA1_27270436_Chip-Seq_PROSTATE_Human1.10303593
94FOXA1_25329375_ChIP-Seq_VCAP_Human1.10303593
95TCF4_23295773_ChIP-Seq_U87_Human1.10149112
96RING1B_27294783_Chip-Seq_ESCs_Mouse1.09577401
97STAT3_18555785_Chip-Seq_ESCs_Mouse1.09564479
98P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09309444
99AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09212451
100OCT4_21477851_ChIP-Seq_ESCs_Mouse1.08856653
101TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.08476888
102GATA3_21878914_ChIP-Seq_MCF-7_Human1.07668170
103TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07236361
104TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.07228414
105TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06889152
106SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.05292333
107TP53_16413492_ChIP-PET_HCT116_Human1.04896448
108P53_22387025_ChIP-Seq_ESCs_Mouse1.03875779
109BCAT_22108803_ChIP-Seq_LS180_Human1.02865970
110RING1B_27294783_Chip-Seq_NPCs_Mouse1.02847406
111EGR1_19032775_ChIP-ChIP_M12_Human1.02765876
112PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.02715537
113CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.00688021
114PCGF2_27294783_Chip-Seq_NPCs_Mouse1.00629894
115ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00549547
116P300_18555785_Chip-Seq_ESCs_Mouse0.98259685
117STAT3_23295773_ChIP-Seq_U87_Human0.98027110
118TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.96921053
119SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.96433106
120SMAD3_21741376_ChIP-Seq_HESCs_Human0.96036810
121EWS_26573619_Chip-Seq_HEK293_Human0.95958317
122KDM2B_26808549_Chip-Seq_REH_Human0.95902401
123FOXA1_21572438_ChIP-Seq_LNCaP_Human0.95810420
124CTCF_18555785_Chip-Seq_ESCs_Mouse0.95708359
125PRDM14_20953172_ChIP-Seq_ESCs_Human0.95606570
126ARNT_22903824_ChIP-Seq_MCF-7_Human0.95203982
127FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94721935
128NR3C1_23031785_ChIP-Seq_PC12_Mouse0.94430376
129SOX2_18555785_Chip-Seq_ESCs_Mouse0.94084755
130NANOG_20526341_ChIP-Seq_ESCs_Human0.93966795
131E2F1_18555785_Chip-Seq_ESCs_Mouse0.93634819
132AR_19668381_ChIP-Seq_PC3_Human0.93628050
133TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93589326
134ZNF217_24962896_ChIP-Seq_MCF-7_Human0.93142942
135KLF5_20875108_ChIP-Seq_MESCs_Mouse0.92509577
136EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.91901651
137TP53_18474530_ChIP-ChIP_U2OS_Human0.91557811
138NANOG_18555785_Chip-Seq_ESCs_Mouse0.91186163
139SMAD4_21741376_ChIP-Seq_EPCs_Human0.91113016
140LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90841470
141SMAD3_21741376_ChIP-Seq_ESCs_Human0.90801481
142WT1_19549856_ChIP-ChIP_CCG9911_Human0.90344728
143CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90061965
144BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.89444045
145RXR_22108803_ChIP-Seq_LS180_Human0.87884405
146PCGF2_27294783_Chip-Seq_ESCs_Mouse0.87475456

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009780_abnormal_chondrocyte_physiolo6.47388774
2MP0000372_irregular_coat_pigmentation5.64959524
3MP0005171_absent_coat_pigmentation5.64136886
4MP0009278_abnormal_bone_marrow3.90948985
5MP0004859_abnormal_synaptic_plasticity3.61051921
6MP0003122_maternal_imprinting3.45821833
7MP0001968_abnormal_touch/_nociception3.42872947
8MP0003136_yellow_coat_color3.42362573
9MP0003880_abnormal_central_pattern3.36909985
10MP0005645_abnormal_hypothalamus_physiol3.15012589
11MP0005408_hypopigmentation3.10804580
12MP0003941_abnormal_skin_development2.96274376
13MP0009745_abnormal_behavioral_response2.81012903
14MP0009046_muscle_twitch2.74164382
15MP0003635_abnormal_synaptic_transmissio2.72880946
16MP0005423_abnormal_somatic_nervous2.55454781
17MP0002064_seizures2.52186460
18MP0004381_abnormal_hair_follicle2.49863502
19MP0002736_abnormal_nociception_after2.45686445
20MP0005646_abnormal_pituitary_gland2.39772203
21MP0006276_abnormal_autonomic_nervous2.39195162
22MP0001440_abnormal_grooming_behavior2.35892699
23MP0003879_abnormal_hair_cell2.28612306
24MP0005360_urolithiasis2.19157781
25MP0001545_abnormal_hematopoietic_system2.17204165
26MP0005397_hematopoietic_system_phenotyp2.17204165
27MP0002572_abnormal_emotion/affect_behav2.06429822
28MP0002063_abnormal_learning/memory/cond2.03231866
29MP0005367_renal/urinary_system_phenotyp2.02774292
30MP0000516_abnormal_urinary_system2.02774292
31MP0003195_calcinosis1.94111663
32MP0000371_diluted_coat_color1.93367393
33MP0005503_abnormal_tendon_morphology1.90919867
34MP0002557_abnormal_social/conspecific_i1.86686667
35MP0002102_abnormal_ear_morphology1.82846956
36MP0001501_abnormal_sleep_pattern1.78998487
37MP0008877_abnormal_DNA_methylation1.77911363
38MP0001984_abnormal_olfaction1.77829355
39MP0001905_abnormal_dopamine_level1.72696594
40MP0004885_abnormal_endolymph1.71268948
41MP0002876_abnormal_thyroid_physiology1.70835457
42MP0000015_abnormal_ear_pigmentation1.69006364
43MP0001486_abnormal_startle_reflex1.67183077
44MP0000681_abnormal_thyroid_gland1.64042988
45MP0002735_abnormal_chemical_nociception1.61994286
46MP0009764_decreased_sensitivity_to1.61883698
47MP0002067_abnormal_sensory_capabilities1.61494556
48MP0002693_abnormal_pancreas_physiology1.58044693
49MP0002272_abnormal_nervous_system1.57891622
50MP0001944_abnormal_pancreas_morphology1.56691870
51MP0003121_genomic_imprinting1.55081749
52MP0000678_abnormal_parathyroid_gland1.55078142
53MP0002095_abnormal_skin_pigmentation1.53900858
54MP0001664_abnormal_digestion1.52486854
55MP0005379_endocrine/exocrine_gland_phen1.47289241
56MP0002638_abnormal_pupillary_reflex1.46907999
57MP0001324_abnormal_eye_pigmentation1.45832107
58MP0003183_abnormal_peptide_metabolism1.45316665
59MP0010234_abnormal_vibrissa_follicle1.43743521
60MP0003878_abnormal_ear_physiology1.41979238
61MP0005377_hearing/vestibular/ear_phenot1.41979238
62MP0002734_abnormal_mechanical_nocicepti1.38297163
63MP0005174_abnormal_tail_pigmentation1.36648285
64MP0006035_abnormal_mitochondrial_morpho1.29043724
65MP0004043_abnormal_pH_regulation1.28606458
66MP0005386_behavior/neurological_phenoty1.25265770
67MP0004924_abnormal_behavior1.25265770
68MP0001502_abnormal_circadian_rhythm1.25091118
69MP0004142_abnormal_muscle_tone1.24780648
70MP0001270_distended_abdomen1.21243451
71MP0001756_abnormal_urination1.20931050
72MP0004145_abnormal_muscle_electrophysio1.19411959
73MP0005257_abnormal_intraocular_pressure1.18221411
74MP0005253_abnormal_eye_physiology1.17280540
75MP0003690_abnormal_glial_cell1.14752405
76MP0002184_abnormal_innervation1.13359822
77MP0002090_abnormal_vision1.12749089
78MP0005167_abnormal_blood-brain_barrier1.09826805
79MP0001970_abnormal_pain_threshold1.09375782
80MP0004270_analgesia1.07540790
81MP0003329_amyloid_beta_deposits1.07463341
82MP0005332_abnormal_amino_acid1.04710184
83MP0010329_abnormal_lipoprotein_level1.04606652
84MP0003123_paternal_imprinting1.04132460
85MP0001529_abnormal_vocalization1.02548254
86MP0000747_muscle_weakness1.01832200
87MP0010678_abnormal_skin_adnexa1.00346352
88MP0000427_abnormal_hair_cycle0.98726435
89MP0002075_abnormal_coat/hair_pigmentati0.95756137
90MP0000751_myopathy0.95497934
91MP0002163_abnormal_gland_morphology0.92937268
92MP0000569_abnormal_digit_pigmentation0.92845852
93MP0005551_abnormal_eye_electrophysiolog0.92520602
94MP0008569_lethality_at_weaning0.92460957
95MP0003638_abnormal_response/metabolism_0.92298312
96MP0002066_abnormal_motor_capabilities/c0.91984578
97MP0005220_abnormal_exocrine_pancreas0.90825207
98MP0003959_abnormal_lean_body0.90802011
99MP0000013_abnormal_adipose_tissue0.90657792
100MP0005394_taste/olfaction_phenotype0.87051896
101MP0005499_abnormal_olfactory_system0.87051896
102MP0002909_abnormal_adrenal_gland0.86822464
103MP0002733_abnormal_thermal_nociception0.85991541
104MP0000778_abnormal_nervous_system0.85722247
105MP0002882_abnormal_neuron_morphology0.85088418
106MP0002254_reproductive_system_inflammat0.84192717
107* MP0002078_abnormal_glucose_homeostasis0.82833674
108MP0008961_abnormal_basal_metabolism0.82089349
109MP0008995_early_reproductive_senescence0.81939302
110MP0000537_abnormal_urethra_morphology0.81389604
111MP0003172_abnormal_lysosome_physiology0.81285496
112MP0005623_abnormal_meninges_morphology0.79900040
113MP0003646_muscle_fatigue0.78811979
114MP0005248_abnormal_Harderian_gland0.78128486
115MP0004883_abnormal_blood_vessel0.77269650
116MP0005164_abnormal_response_to0.76044080
117MP0005409_darkened_coat_color0.75824209
118MP0003011_delayed_dark_adaptation0.75375504
119MP0000631_abnormal_neuroendocrine_gland0.74788116
120MP0001986_abnormal_taste_sensitivity0.74725099
121MP0005448_abnormal_energy_balance0.73570360
122MP0008872_abnormal_physiological_respon0.73512097
123MP0005389_reproductive_system_phenotype0.72880228
124MP0008775_abnormal_heart_ventricle0.72197056
125MP0001919_abnormal_reproductive_system0.71767798
126MP0004782_abnormal_surfactant_physiolog0.71690343
127MP0002837_dystrophic_cardiac_calcinosis0.71395000
128* MP0002069_abnormal_eating/drinking_beha0.71261035
129MP0003633_abnormal_nervous_system0.69775377
130MP0003632_abnormal_nervous_system0.68658471
131MP0002229_neurodegeneration0.68076585
132MP0001963_abnormal_hearing_physiology0.67978588
133MP0004085_abnormal_heartbeat0.67554422
134MP0003950_abnormal_plasma_membrane0.67548069
135MP0005195_abnormal_posterior_eye0.67180260
136MP0001186_pigmentation_phenotype0.66988529
137MP0004742_abnormal_vestibular_system0.66672987
138MP0010386_abnormal_urinary_bladder0.66428489
139MP0000003_abnormal_adipose_tissue0.66330772
140MP0003634_abnormal_glial_cell0.66295528
141MP0009333_abnormal_splenocyte_physiolog0.65892917
142MP0001765_abnormal_ion_homeostasis0.65801158
143MP0003631_nervous_system_phenotype0.65619455
144MP0005670_abnormal_white_adipose0.65163621
145MP0002752_abnormal_somatic_nervous0.65095411
146MP0006036_abnormal_mitochondrial_physio0.64821300
147MP0010771_integument_phenotype0.62900228
148MP0003045_fibrosis0.61825855
149MP0003787_abnormal_imprinting0.60573284
150MP0002877_abnormal_melanocyte_morpholog0.59933007
151MP0005075_abnormal_melanosome_morpholog0.59930222
152MP0006072_abnormal_retinal_apoptosis0.59428675
153MP0006138_congestive_heart_failure0.58377401
154MP0004811_abnormal_neuron_physiology0.58307706

Predicted human phenotypes

RankGene SetZ-score
1Blue irides (HP:0000635)7.06992185
2Intestinal atresia (HP:0011100)6.88918264
3Focal motor seizures (HP:0011153)5.88793673
4Aplasia/Hypoplasia affecting the retina (HP:0008061)5.16339548
5Large for gestational age (HP:0001520)5.08553352
6Aplasia/Hypoplasia of the macula (HP:0008059)5.06915443
7Volvulus (HP:0002580)4.99565658
8Iris hypopigmentation (HP:0007730)4.98131913
9Ocular albinism (HP:0001107)4.68961429
10Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.61593812
11Pancreatic islet-cell hyperplasia (HP:0004510)4.52319923
12Aplasia/Hypoplasia of the fovea (HP:0008060)4.49231250
13Hypoplasia of the fovea (HP:0007750)4.49231250
14Abnormality of the aortic arch (HP:0012303)4.39141811
15Generalized hypopigmentation (HP:0007513)4.27142566
16Broad alveolar ridges (HP:0000187)4.27054276
17Gastrointestinal atresia (HP:0002589)3.97958624
18Focal seizures (HP:0007359)3.91708298
19Gaze-evoked nystagmus (HP:0000640)3.87229908
20Abnormal eating behavior (HP:0100738)3.74390580
21Congenital sensorineural hearing impairment (HP:0008527)3.74368878
22Thickened helices (HP:0000391)3.70566938
23Visual hallucinations (HP:0002367)3.70177154
24Poor head control (HP:0002421)3.63113336
25Polyphagia (HP:0002591)3.57818132
26Abnormality of the fovea (HP:0000493)3.52331868
27Febrile seizures (HP:0002373)3.51223809
28Generalized tonic-clonic seizures (HP:0002069)3.44952431
29Mesangial abnormality (HP:0001966)3.42206462
30Atonic seizures (HP:0010819)3.32002044
31Absence seizures (HP:0002121)3.23745332
32Abnormality of the pancreatic islet cells (HP:0006476)3.18136037
33Abnormality of endocrine pancreas physiology (HP:0012093)3.18136037
34Cerebellar dysplasia (HP:0007033)3.15480505
35Hyperthyroidism (HP:0000836)3.11832122
36Large eyes (HP:0001090)3.10564452
37Tubular atrophy (HP:0000092)3.03014182
38Oligodontia (HP:0000677)2.98939328
39Abnormality of calcium-phosphate metabolism (HP:0100530)2.97701975
40White forelock (HP:0002211)2.96030470
41Pheochromocytoma (HP:0002666)2.95294518
42Cutaneous melanoma (HP:0012056)2.93634079
43Lissencephaly (HP:0001339)2.93590786
44Myokymia (HP:0002411)2.92495724
45Hypopigmentation of the fundus (HP:0007894)2.86908535
46Abnormal ciliary motility (HP:0012262)2.86497781
47Dialeptic seizures (HP:0011146)2.83391597
48Congenital ichthyosiform erythroderma (HP:0007431)2.82776288
49Hypothermia (HP:0002045)2.79845016
50Pancreatic fibrosis (HP:0100732)2.78566672
51Generalized hypopigmentation of hair (HP:0011358)2.75382503
52Agitation (HP:0000713)2.67152707
53Hypoplasia of the iris (HP:0007676)2.65248040
54Progressive cerebellar ataxia (HP:0002073)2.65221478
55Oligomenorrhea (HP:0000876)2.63559081
56Congenital stationary night blindness (HP:0007642)2.59097163
57Retinal dysplasia (HP:0007973)2.59089403
58Pendular nystagmus (HP:0012043)2.57370980
59Dynein arm defect of respiratory motile cilia (HP:0012255)2.56724601
60Absent/shortened dynein arms (HP:0200106)2.56724601
61Abnormality of the axillary hair (HP:0100134)2.56033738
62Abnormality of secondary sexual hair (HP:0009888)2.56033738
63Abnormality of the corticospinal tract (HP:0002492)2.52496064
64Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.51484724
65Degeneration of the lateral corticospinal tracts (HP:0002314)2.51484724
66Calf muscle hypertrophy (HP:0008981)2.50638331
67Attenuation of retinal blood vessels (HP:0007843)2.50377988
68Scanning speech (HP:0002168)2.50201474
69Patchy hypopigmentation of hair (HP:0011365)2.49450792
70Epileptic encephalopathy (HP:0200134)2.49032668
71Hyperpituitarism (HP:0010514)2.48656924
72Goiter (HP:0000853)2.47518486
73Ketoacidosis (HP:0001993)2.44945444
74Neuroendocrine neoplasm (HP:0100634)2.43299987
75Abnormal respiratory epithelium morphology (HP:0012253)2.43006193
76Abnormal respiratory motile cilium morphology (HP:0005938)2.43006193
77Progressive inability to walk (HP:0002505)2.42122053
78Hypoventilation (HP:0002791)2.41603100
79Episodic fever (HP:0001954)2.41284985
80Subacute progressive viral hepatitis (HP:0006572)2.39584268
81Abnormality of the vitreous humor (HP:0004327)2.38191345
82Abnormal respiratory motile cilium physiology (HP:0012261)2.38040801
83Pancreatic cysts (HP:0001737)2.37257365
84Anxiety (HP:0000739)2.36433905
85Intention tremor (HP:0002080)2.34793007
86Gait imbalance (HP:0002141)2.32531519
87Amelogenesis imperfecta (HP:0000705)2.31163254
88Muscle hypertrophy of the lower extremities (HP:0008968)2.29844424
89Impaired vibration sensation in the lower limbs (HP:0002166)2.27053186
90Truncal ataxia (HP:0002078)2.26942672
91Molar tooth sign on MRI (HP:0002419)2.24437044
92Abnormality of midbrain morphology (HP:0002418)2.24437044
93Optic nerve hypoplasia (HP:0000609)2.23379841
94Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.19184839
95Ankle clonus (HP:0011448)2.15564656
96Testicular neoplasm (HP:0010788)2.14721888
97Broad-based gait (HP:0002136)2.14384011
98Abnormality of the ileum (HP:0001549)2.14349006
99Bony spicule pigmentary retinopathy (HP:0007737)2.13574187
100Tented upper lip vermilion (HP:0010804)2.13023762
101Hypoplasia of the pons (HP:0012110)2.11867151
102Hypercortisolism (HP:0001578)2.11741159
103Narrow nasal bridge (HP:0000446)2.11524707
104Hepatocellular necrosis (HP:0001404)2.11284898
105Spinal cord compression (HP:0002176)2.11096169
106Esotropia (HP:0000565)2.08109411
107Hypoproteinemia (HP:0003075)2.08106918
108Peripheral hypomyelination (HP:0007182)2.08085928
109Abnormality of the pons (HP:0007361)2.07518350
110Poor speech (HP:0002465)2.06731186
111Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.06085491
112Heterochromia iridis (HP:0001100)2.05696707
113Spastic tetraplegia (HP:0002510)2.05304053
114Psychosis (HP:0000709)2.04707894
115Polydipsia (HP:0001959)2.02862801
116Abnormal drinking behavior (HP:0030082)2.02862801
117Depression (HP:0000716)2.02712298
118Poor suck (HP:0002033)2.02568794
1193-Methylglutaconic aciduria (HP:0003535)2.01714692
120Supranuclear gaze palsy (HP:0000605)2.00429089
121Conjunctival hamartoma (HP:0100780)2.00335660
122Severe visual impairment (HP:0001141)2.00321342
123Thyroid-stimulating hormone excess (HP:0002925)10.7632954
124Neurofibrillary tangles (HP:0002185)1.99379439
125Congenital primary aphakia (HP:0007707)1.98449802
126Dysmetria (HP:0001310)1.97242592
127Abnormality of macular pigmentation (HP:0008002)1.95933787
128Severe muscular hypotonia (HP:0006829)1.94769299
129Drooling (HP:0002307)1.94273991
130Excessive salivation (HP:0003781)1.94273991
131Restlessness (HP:0000711)1.94190460
132Vascular calcification (HP:0004934)1.92934147
133Ankyloglossia (HP:0010296)1.92758857
134Abnormal hair laboratory examination (HP:0003328)1.92632084
135Tachypnea (HP:0002789)1.92308849
136Mitochondrial inheritance (HP:0001427)1.91766121
137Pachygyria (HP:0001302)1.89805421
138Amblyopia (HP:0000646)1.89354641
139Nephrogenic diabetes insipidus (HP:0009806)1.88838165
140Abnormal gallbladder physiology (HP:0012438)1.88763244
141Cholecystitis (HP:0001082)1.88763244
142Increased corneal curvature (HP:0100692)1.88364066
143Keratoconus (HP:0000563)1.88364066
144Failure to thrive in infancy (HP:0001531)1.86881929
145Limb dystonia (HP:0002451)1.86318832
146Tubulointerstitial nephritis (HP:0001970)1.85702772
147Hamartoma of the eye (HP:0010568)1.84966232
148Acute necrotizing encephalopathy (HP:0006965)1.84200883
149Progressive macrocephaly (HP:0004481)1.83921329
150Rhinitis (HP:0012384)1.83462453
151Abnormality of the labia minora (HP:0012880)1.83440355
152Medial flaring of the eyebrow (HP:0010747)1.83407229
153Hemiparesis (HP:0001269)1.83101264
154Hypophosphatemic rickets (HP:0004912)1.83099891
155Metaphyseal dysplasia (HP:0100255)1.81009756
156Abnormality of aromatic amino acid family metabolism (HP:0004338)1.80576932
157Hypohidrosis (HP:0000966)1.80524865
158Hypoalbuminemia (HP:0003073)1.79869181
159Abnormal albumin level (HP:0012116)1.79869181
160Cerebral inclusion bodies (HP:0100314)1.79715951
161Sleep apnea (HP:0010535)1.79157520
162Entropion (HP:0000621)1.78895898
163Myositis (HP:0100614)1.78671281
164Akinesia (HP:0002304)1.78030037
165Specific learning disability (HP:0001328)1.77735008
166Abnormal rod and cone electroretinograms (HP:0008323)1.76555057
167Exotropia (HP:0000577)1.76535409
168Cerebral hemorrhage (HP:0001342)1.75758380
169Dysdiadochokinesis (HP:0002075)1.74740555
170Aplasia/Hypoplasia of the tibia (HP:0005772)1.74690854
171Methylmalonic aciduria (HP:0012120)1.73894279
172Type II lissencephaly (HP:0007260)1.73849849
173Hydroxyprolinuria (HP:0003080)1.73112775
174Abnormality of proline metabolism (HP:0010907)1.73112775
175True hermaphroditism (HP:0010459)1.72564961
176Abnormality of the alveolar ridges (HP:0006477)1.72519092
177Ketosis (HP:0001946)1.71933539
178Abnormal mitochondria in muscle tissue (HP:0008316)1.70876312
179Hyperventilation (HP:0002883)1.70638104
180Abolished electroretinogram (ERG) (HP:0000550)1.69908414

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R6.24993879
2GRK74.41571758
3TNIK3.76472319
4NTRK33.45818418
5PINK13.23692076
6MAP3K92.99334094
7MAP3K122.87285856
8FGFR22.73941347
9CASK2.73429461
10PIM22.54899524
11MAP3K42.46459018
12ACVR1B2.36409041
13MAP3K132.34527719
14MAP2K72.33853287
15MAP2K42.21971698
16ERN12.10867990
17FER1.96411737
18MET1.95681577
19MARK11.74701803
20NTRK21.74674591
21WNK31.71832109
22GRK11.70090723
23EPHA31.68145509
24BMPR1B1.50173885
25AKT31.49160494
26BMX1.43769869
27MINK11.43240736
28ADRBK11.38191560
29TAOK31.38169140
30TNK21.34443269
31STK241.31857887
32UHMK11.30562882
33FRK1.29726888
34MST41.20203267
35FES1.19334584
36PAK31.18323377
37CAMKK21.12483134
38NME11.11590598
39MAPK111.09984828
40PKN21.09618423
41TAOK11.07037617
42NTRK11.06237085
43ARAF1.03812631
44LATS21.03372892
45KSR21.02964044
46TGFBR11.01401655
47MAPK131.00885908
48CAMK2A0.99135765
49FGFR30.97875463
50SCYL20.92437846
51CDK50.89760286
52PRKD30.86363274
53PRKCH0.85176408
54STK390.81638683
55SIK20.80317104
56DYRK30.80165433
57ADRBK20.79415485
58PRKCI0.79359172
59IRAK10.77537984
60MAP3K10.77411825
61PRKCE0.76979860
62CDK190.76066405
63STK38L0.75956842
64MAP4K20.74589092
65STK30.73115723
66PNCK0.72255503
67MAP2K60.71684913
68RET0.67614837
69DDR20.67044444
70MAPK150.66722539
71ALK0.64288328
72BRSK20.62076678
73CAMK2B0.60668636
74MAP3K60.60664446
75DYRK1B0.58834125
76OXSR10.57197745
77CAMKK10.57164754
78PTK2B0.56666760
79ERBB20.55261301
80DAPK20.55058847
81MOS0.54945452
82PLK20.54146788
83PHKG10.53691012
84PHKG20.53691012
85PIK3CG0.53208029
86PAK60.52934165
87INSRR0.52309432
88KSR10.52299805
89MYLK0.51646257
90FLT30.51455076
91HIPK20.50864088
92CAMK10.50088451
93CSNK1G20.48734205
94CSNK1G30.47157294
95WNK40.46739941
96GSK3A0.45706267
97MARK30.45687032
98CSNK1A1L0.45676700
99CAMK1G0.44694732
100PRKCG0.43821952
101MARK20.42664619
102FGR0.42441618
103SGK10.41851663
104STK380.41206676
105PRKG20.40483844
106PRKCQ0.39408642
107CAMK2D0.38672487
108PRKACA0.38265473
109IRAK30.38161894
110CDC42BPA0.38064041
111ABL20.37791268
112EPHA40.37609134
113STK110.37427413
114PRKD20.36011311
115PRKCA0.33942216
116MAP3K50.33385324
117MAPK120.33343259
118PRKAA20.33076624
119ABL10.32308227
120PRKG10.32213579
121CSNK1D0.30987272
122RPS6KA30.30135676
123AKT20.30055399
124CSNK1A10.30038033
125EIF2AK30.29985739
126WEE10.29906795
127PRKACG0.29033810
128CSNK1G10.28523088
129ROCK10.28323050
130MAP2K10.27646389
131LMTK20.27587181
132ZAK0.27097591
133CAMK1D0.27090874
134SGK2230.26701852
135SGK4940.26701852
136TYRO30.26477557
137CSNK1E0.26180415
138PRKCB0.25870434
139ERBB30.25862240
140DAPK30.25789406
141PRKAA10.24723958
142BRSK10.24412013
143DYRK1A0.24298558
144PRKCZ0.24129349
145TRPM70.23100072
146BCR0.21011411
147LIMK10.20473530
148RIPK10.18692686

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.53749197
2Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.15813227
3Maturity onset diabetes of the young_Homo sapiens_hsa049503.10499399
4GABAergic synapse_Homo sapiens_hsa047273.08636763
5Oxidative phosphorylation_Homo sapiens_hsa001903.07934332
6Synaptic vesicle cycle_Homo sapiens_hsa047212.96441746
7Collecting duct acid secretion_Homo sapiens_hsa049662.78434621
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.73762955
9Morphine addiction_Homo sapiens_hsa050322.58994681
10Parkinsons disease_Homo sapiens_hsa050122.22690284
11Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.11461998
12Glutamatergic synapse_Homo sapiens_hsa047242.11084305
13Taste transduction_Homo sapiens_hsa047422.10417142
14Serotonergic synapse_Homo sapiens_hsa047262.06334148
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.06139972
16Tyrosine metabolism_Homo sapiens_hsa003501.99762349
17Olfactory transduction_Homo sapiens_hsa047401.99109362
18Sphingolipid metabolism_Homo sapiens_hsa006001.96081489
19Steroid hormone biosynthesis_Homo sapiens_hsa001401.95302189
20Circadian entrainment_Homo sapiens_hsa047131.95257214
21Alzheimers disease_Homo sapiens_hsa050101.93977691
22Cardiac muscle contraction_Homo sapiens_hsa042601.88838831
23Linoleic acid metabolism_Homo sapiens_hsa005911.87543389
24Long-term depression_Homo sapiens_hsa047301.80848137
25Vibrio cholerae infection_Homo sapiens_hsa051101.79166298
26Renin-angiotensin system_Homo sapiens_hsa046141.78640867
27Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.67485221
28Huntingtons disease_Homo sapiens_hsa050161.67479388
29Dopaminergic synapse_Homo sapiens_hsa047281.65924241
30Glycosaminoglycan degradation_Homo sapiens_hsa005311.64310208
31Long-term potentiation_Homo sapiens_hsa047201.61179261
32* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.60927627
33Renin secretion_Homo sapiens_hsa049241.58693574
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.56673406
35Melanogenesis_Homo sapiens_hsa049161.52128771
36Tryptophan metabolism_Homo sapiens_hsa003801.51000173
37Cocaine addiction_Homo sapiens_hsa050301.48005608
38Amphetamine addiction_Homo sapiens_hsa050311.46488845
39Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.40406255
40Cyanoamino acid metabolism_Homo sapiens_hsa004601.39744336
41Arachidonic acid metabolism_Homo sapiens_hsa005901.38419025
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.37773493
43Salivary secretion_Homo sapiens_hsa049701.37307723
44Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.35064721
45Folate biosynthesis_Homo sapiens_hsa007901.28139313
46Insulin secretion_Homo sapiens_hsa049111.26515284
47Cholinergic synapse_Homo sapiens_hsa047251.26432911
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.21653556
49Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.19370930
50Oxytocin signaling pathway_Homo sapiens_hsa049211.16985281
51Gastric acid secretion_Homo sapiens_hsa049711.16626807
52Nitrogen metabolism_Homo sapiens_hsa009101.15449785
53Estrogen signaling pathway_Homo sapiens_hsa049151.13619818
54Dorso-ventral axis formation_Homo sapiens_hsa043201.05623191
55Aldosterone synthesis and secretion_Homo sapiens_hsa049251.04384635
56Butanoate metabolism_Homo sapiens_hsa006501.03052526
57Circadian rhythm_Homo sapiens_hsa047101.02364947
58Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.02284853
59Calcium signaling pathway_Homo sapiens_hsa040201.01828816
60Axon guidance_Homo sapiens_hsa043601.00411874
61Type II diabetes mellitus_Homo sapiens_hsa049300.97776689
62Selenocompound metabolism_Homo sapiens_hsa004500.97422332
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.96914776
64Glycerolipid metabolism_Homo sapiens_hsa005610.96672835
65Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.95736353
66Vitamin B6 metabolism_Homo sapiens_hsa007500.94373048
67Arginine biosynthesis_Homo sapiens_hsa002200.94158169
68Sulfur metabolism_Homo sapiens_hsa009200.93930656
69Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.93906400
70Caffeine metabolism_Homo sapiens_hsa002320.93281349
71Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.93053748
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.91722565
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.91354260
74Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.91016288
75Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.89333419
76GnRH signaling pathway_Homo sapiens_hsa049120.87160683
77Mineral absorption_Homo sapiens_hsa049780.84415584
78Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.83346875
79Retinol metabolism_Homo sapiens_hsa008300.81183716
80Vascular smooth muscle contraction_Homo sapiens_hsa042700.80458814
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.80395261
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.80225477
83Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.78223548
84Steroid biosynthesis_Homo sapiens_hsa001000.76790585
85Thyroid hormone synthesis_Homo sapiens_hsa049180.75875455
86cAMP signaling pathway_Homo sapiens_hsa040240.75438285
87Gap junction_Homo sapiens_hsa045400.75391767
88cGMP-PKG signaling pathway_Homo sapiens_hsa040220.75355410
89Primary bile acid biosynthesis_Homo sapiens_hsa001200.71653001
90beta-Alanine metabolism_Homo sapiens_hsa004100.69995096
91Sulfur relay system_Homo sapiens_hsa041220.69241661
92Metabolic pathways_Homo sapiens_hsa011000.69047689
93Complement and coagulation cascades_Homo sapiens_hsa046100.68909575
94Prion diseases_Homo sapiens_hsa050200.68635690
95Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.68588970
96Rheumatoid arthritis_Homo sapiens_hsa053230.67717440
97Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65436608
98Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.63430195
99Dilated cardiomyopathy_Homo sapiens_hsa054140.63186725
100Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63135862
101Phototransduction_Homo sapiens_hsa047440.60839147
102Lysosome_Homo sapiens_hsa041420.60661289
103Chemical carcinogenesis_Homo sapiens_hsa052040.60544750
104Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.59271000
105Fatty acid degradation_Homo sapiens_hsa000710.55219916
106Basal transcription factors_Homo sapiens_hsa030220.54410214
107Peroxisome_Homo sapiens_hsa041460.52875333
108Protein export_Homo sapiens_hsa030600.52836800
109Histidine metabolism_Homo sapiens_hsa003400.51421968
110Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51312328
111Glutathione metabolism_Homo sapiens_hsa004800.50713257
112Fanconi anemia pathway_Homo sapiens_hsa034600.50198176
113Propanoate metabolism_Homo sapiens_hsa006400.50161194
114Alcoholism_Homo sapiens_hsa050340.49979356
115Renal cell carcinoma_Homo sapiens_hsa052110.49788467
116SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49559170
117Glioma_Homo sapiens_hsa052140.48817662
118Fatty acid elongation_Homo sapiens_hsa000620.48117103
119One carbon pool by folate_Homo sapiens_hsa006700.47848064
120Starch and sucrose metabolism_Homo sapiens_hsa005000.47121629
121Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.46306026
122Glucagon signaling pathway_Homo sapiens_hsa049220.46052092
123Phenylalanine metabolism_Homo sapiens_hsa003600.45447205
124Type I diabetes mellitus_Homo sapiens_hsa049400.45013815
125Ras signaling pathway_Homo sapiens_hsa040140.43353554
126ErbB signaling pathway_Homo sapiens_hsa040120.42812705
127Bile secretion_Homo sapiens_hsa049760.41800407
128Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41618710
129Melanoma_Homo sapiens_hsa052180.41364699
130Galactose metabolism_Homo sapiens_hsa000520.41194237
131Adipocytokine signaling pathway_Homo sapiens_hsa049200.41013706
132Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.40842241
133Phagosome_Homo sapiens_hsa041450.39176347
134MAPK signaling pathway_Homo sapiens_hsa040100.39047117
135Oocyte meiosis_Homo sapiens_hsa041140.38715547
136Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.36073982
137Fatty acid metabolism_Homo sapiens_hsa012120.36051765
138Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.35492740
139Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.33608854
140Sphingolipid signaling pathway_Homo sapiens_hsa040710.33594018
141N-Glycan biosynthesis_Homo sapiens_hsa005100.33062461
142Phospholipase D signaling pathway_Homo sapiens_hsa040720.29415076
143Insulin signaling pathway_Homo sapiens_hsa049100.28668553
144Ether lipid metabolism_Homo sapiens_hsa005650.27997448
145ABC transporters_Homo sapiens_hsa020100.26859095
146Pancreatic secretion_Homo sapiens_hsa049720.26146075
147Ovarian steroidogenesis_Homo sapiens_hsa049130.25100838
148Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.24737409
149Choline metabolism in cancer_Homo sapiens_hsa052310.23866497
150Carbohydrate digestion and absorption_Homo sapiens_hsa049730.23773020
151Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.23195675

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