BRF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of the multiple subunits of the RNA polymerase III transcription factor complex required for transcription of genes with promoter elements upstream of the initiation site. The product of this gene, a TFIIB-like factor, is directly recruited to the TATA-box of polymerase III small nuclear RNA gene promoters through its interaction with the TATA-binding protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of uterine smooth muscle contraction (GO:0070474)6.68924619
2purine nucleotide salvage (GO:0032261)5.59059366
3tolerance induction (GO:0002507)5.55250051
4DNA deamination (GO:0045006)5.40893875
5regulation of uterine smooth muscle contraction (GO:0070472)5.40333526
6mitotic metaphase plate congression (GO:0007080)5.25944428
7cellular zinc ion homeostasis (GO:0006882)5.02403141
8RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.92666428
9tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.92666428
10homocysteine metabolic process (GO:0050667)4.61769537
11activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO4.54173980
12folic acid-containing compound biosynthetic process (GO:0009396)4.47283761
13protein neddylation (GO:0045116)4.39315805
14actin filament depolymerization (GO:0030042)4.29863747
15protein localization to chromosome, centromeric region (GO:0071459)4.24956590
16metaphase plate congression (GO:0051310)4.22982647
17ribosome biogenesis (GO:0042254)4.22438566
18maturation of 5.8S rRNA (GO:0000460)4.21649741
19rRNA modification (GO:0000154)4.20826139
20attachment of spindle microtubules to kinetochore (GO:0008608)4.16998941
21microtubule depolymerization (GO:0007019)4.05468198
22mitochondrial respiratory chain complex I assembly (GO:0032981)4.00597387
23NADH dehydrogenase complex assembly (GO:0010257)4.00597387
24mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.00597387
25cysteine metabolic process (GO:0006534)4.00453667
26piRNA metabolic process (GO:0034587)3.98944015
27DNA replication initiation (GO:0006270)3.97481449
28protein K6-linked ubiquitination (GO:0085020)3.93677525
29maturation of SSU-rRNA (GO:0030490)3.91079557
30DNA replication checkpoint (GO:0000076)3.86996673
31protein localization to kinetochore (GO:0034501)3.83571607
32regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.83523091
33organelle membrane fusion (GO:0090174)3.82081641
34establishment of chromosome localization (GO:0051303)3.80033760
35protein-cofactor linkage (GO:0018065)3.78947771
36zinc ion homeostasis (GO:0055069)3.78632762
37ribonucleoprotein complex biogenesis (GO:0022613)3.76985893
38chromatin remodeling at centromere (GO:0031055)3.75912951
39regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.75310125
40mitotic sister chromatid segregation (GO:0000070)3.74741980
417-methylguanosine mRNA capping (GO:0006370)3.74330267
42CENP-A containing nucleosome assembly (GO:0034080)3.72757060
43rRNA methylation (GO:0031167)3.72474513
44kinetochore assembly (GO:0051382)3.72183500
45DNA strand elongation involved in DNA replication (GO:0006271)3.70164600
46regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.69996618
47nucleotide salvage (GO:0043173)3.69620283
48modulation by virus of host process (GO:0019054)3.69018481
49purine nucleobase biosynthetic process (GO:0009113)3.68908500
50positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.67582687
51telomere maintenance via semi-conservative replication (GO:0032201)3.67082597
52mitochondrial respiratory chain complex assembly (GO:0033108)3.64712100
53mitotic nuclear envelope reassembly (GO:0007084)3.63213740
54nuclear envelope reassembly (GO:0031468)3.63213740
55protein complex biogenesis (GO:0070271)3.62797357
56rRNA processing (GO:0006364)3.62574708
57transcription elongation from RNA polymerase III promoter (GO:0006385)3.62368136
58termination of RNA polymerase III transcription (GO:0006386)3.62368136
597-methylguanosine RNA capping (GO:0009452)3.61809471
60RNA capping (GO:0036260)3.61809471
61sulfur amino acid catabolic process (GO:0000098)3.59708494
62pteridine-containing compound biosynthetic process (GO:0042559)3.57139812
63ribosomal large subunit biogenesis (GO:0042273)3.56943993
64mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.55423786
65spliceosomal snRNP assembly (GO:0000387)3.55372808
66regulation of translational elongation (GO:0006448)3.51845954
67rRNA metabolic process (GO:0016072)3.50954770
68poly(A)+ mRNA export from nucleus (GO:0016973)3.50125500
69tRNA modification (GO:0006400)3.49848314
70DNA strand elongation (GO:0022616)3.48942770
71transcription elongation from RNA polymerase I promoter (GO:0006362)3.46940807
72histone exchange (GO:0043486)3.45774233
73transcription from RNA polymerase I promoter (GO:0006360)3.45540898
74viral protein processing (GO:0019082)3.45165875
75termination of RNA polymerase I transcription (GO:0006363)3.44483294
76iron-sulfur cluster assembly (GO:0016226)3.43990448
77metallo-sulfur cluster assembly (GO:0031163)3.43990448
78meiotic cell cycle (GO:0051321)3.43899301
79ribosome assembly (GO:0042255)3.43786147
80kinetochore organization (GO:0051383)3.42865000
81mitotic nuclear envelope disassembly (GO:0007077)3.41899786
82nucleobase biosynthetic process (GO:0046112)3.41819650
83negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.41417845
84ATP hydrolysis coupled proton transport (GO:0015991)3.39944156
85energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.39944156
86IMP biosynthetic process (GO:0006188)3.39180486
87positive regulation of chromosome segregation (GO:0051984)3.38986903
88negative regulation of chromosome segregation (GO:0051985)3.38654560
89respiratory electron transport chain (GO:0022904)3.38521046
90mitochondrial RNA metabolic process (GO:0000959)3.36725504
91regulation of mitotic spindle organization (GO:0060236)3.35365393
92transcription-coupled nucleotide-excision repair (GO:0006283)3.35048391
93telomere maintenance via recombination (GO:0000722)3.34793259
94DNA replication-independent nucleosome organization (GO:0034724)3.33291676
95DNA replication-independent nucleosome assembly (GO:0006336)3.33291676
96spindle checkpoint (GO:0031577)3.33282480
97negative regulation of mitotic sister chromatid separation (GO:2000816)3.31815236
98negative regulation of mitotic sister chromatid segregation (GO:0033048)3.31815236
99negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.31815236
100negative regulation of sister chromatid segregation (GO:0033046)3.31815236
101electron transport chain (GO:0022900)3.31749621
102regulation of translational fidelity (GO:0006450)3.31703041
103energy coupled proton transport, down electrochemical gradient (GO:0015985)3.30481891
104ATP synthesis coupled proton transport (GO:0015986)3.30481891
105regulation of chromosome segregation (GO:0051983)3.30314001
106regulation of spindle organization (GO:0090224)3.29576682
107regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.26978450
108regulation of exit from mitosis (GO:0007096)3.25003439
109negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.21951377
110preassembly of GPI anchor in ER membrane (GO:0016254)3.21595284
111ribosomal small subunit assembly (GO:0000028)3.21151113
112telomere maintenance via telomere lengthening (GO:0010833)3.20465987
113regulation of mitotic metaphase/anaphase transition (GO:0030071)3.19273207
114cullin deneddylation (GO:0010388)3.18256958
115mitotic spindle checkpoint (GO:0071174)3.17615577
116histone H2A monoubiquitination (GO:0035518)3.17450835
117mitotic spindle assembly checkpoint (GO:0007094)3.17139659
118nuclear envelope disassembly (GO:0051081)3.15909820
119membrane disassembly (GO:0030397)3.15909820
120negative regulation of B cell apoptotic process (GO:0002903)3.15313289
121establishment of protein localization to mitochondrial membrane (GO:0090151)3.14391656
122positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.13826708
123spindle assembly checkpoint (GO:0071173)3.13592845
124chaperone-mediated protein transport (GO:0072321)3.13258658
125tRNA processing (GO:0008033)3.12434639
126IMP metabolic process (GO:0046040)3.12309982
127mitotic recombination (GO:0006312)3.12031828
128ribosomal small subunit biogenesis (GO:0042274)3.11709492
129meiotic chromosome segregation (GO:0045132)3.11380762
130maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.10462061
131adenosine metabolic process (GO:0046085)3.10330467
132anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.08407144
133pseudouridine synthesis (GO:0001522)3.07774724
134proteasome assembly (GO:0043248)3.07370303
135positive regulation of gamma-delta T cell activation (GO:0046645)3.06648512
136transcription initiation from RNA polymerase I promoter (GO:0006361)3.06425410
137regulation of mitotic sister chromatid separation (GO:0010965)3.05276404
138regulation of mitotic sister chromatid segregation (GO:0033047)3.05276404
139regulation of sister chromatid segregation (GO:0033045)3.05276404
140RNA methylation (GO:0001510)3.04361150
141protein localization to chromosome (GO:0034502)3.04012190
142base-excision repair, AP site formation (GO:0006285)3.01698275
143inner cell mass cell proliferation (GO:0001833)3.01245236
144protein K11-linked ubiquitination (GO:0070979)3.01099209
145succinate metabolic process (GO:0006105)3.00046105
146fucosylation (GO:0036065)2.99959977
147cellular component biogenesis (GO:0044085)2.99678089
148sister chromatid segregation (GO:0000819)2.98608403
149regulation of mitochondrial translation (GO:0070129)2.98563607
150regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.98456623
151tRNA methylation (GO:0030488)2.96661500
152establishment of protein localization to mitochondrion (GO:0072655)2.96497190
153spliceosomal complex assembly (GO:0000245)2.94721292
154histone H2A ubiquitination (GO:0033522)2.94459984
155transcription elongation from RNA polymerase II promoter (GO:0006368)2.94446591
156protein deneddylation (GO:0000338)2.94146071
157DNA-templated transcription, elongation (GO:0006354)2.93534654
158chromosome segregation (GO:0007059)2.92144588
159mitotic chromosome condensation (GO:0007076)2.90335090
160peptidyl-histidine modification (GO:0018202)2.89607655
161histone arginine methylation (GO:0034969)2.89204313
162purine-containing compound salvage (GO:0043101)2.89129186
163peptidyl-arginine omega-N-methylation (GO:0035247)2.88842356
164folic acid metabolic process (GO:0046655)2.87856364
165S-adenosylmethionine metabolic process (GO:0046500)2.87327616
166fat-soluble vitamin biosynthetic process (GO:0042362)2.84977597
167basement membrane organization (GO:0071711)2.84961905
168viral transcription (GO:0019083)2.83795281
169protein targeting to mitochondrion (GO:0006626)2.82132230
170inner mitochondrial membrane organization (GO:0007007)2.80738040
171deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.80165255
172tRNA metabolic process (GO:0006399)2.79455970
173protein insertion into membrane (GO:0051205)2.78498941
174phosphatidylinositol acyl-chain remodeling (GO:0036149)2.77236577
175protein carboxylation (GO:0018214)2.77104143
176peptidyl-glutamic acid carboxylation (GO:0017187)2.77104143
177negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.75465818
178polyamine metabolic process (GO:0006595)2.75051333
179mannosylation (GO:0097502)2.73949485
180modulation by symbiont of host cellular process (GO:0044068)2.73601965
181intracellular protein transmembrane import (GO:0044743)2.72583653
182sulfur amino acid biosynthetic process (GO:0000097)2.72353335
183purine deoxyribonucleotide catabolic process (GO:0009155)2.71232922
184ubiquinone biosynthetic process (GO:0006744)2.71212353
185regulation of gamma-delta T cell differentiation (GO:0045586)2.70871880
186positive regulation of smooth muscle contraction (GO:0045987)2.68893047
187polyamine biosynthetic process (GO:0006596)2.68575382
188hydrogen ion transmembrane transport (GO:1902600)2.68294398
189negative regulation of ligase activity (GO:0051352)2.68199160

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.70567309
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.34123211
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.34091163
4MYC_18555785_ChIP-Seq_MESCs_Mouse4.21566115
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.62285213
6* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.54048770
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.37892990
8* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.28847265
9E2F4_17652178_ChIP-ChIP_JURKAT_Human3.26285859
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.10964492
11* ETS1_20019798_ChIP-Seq_JURKAT_Human3.08516148
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.99526160
13* GABP_17652178_ChIP-ChIP_JURKAT_Human2.97964150
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.97260134
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.90619489
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.89044875
17EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.84905945
18MYC_19030024_ChIP-ChIP_MESCs_Mouse2.82748963
19* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.45961466
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.39988632
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.32162676
22* XRN2_22483619_ChIP-Seq_HELA_Human2.28094345
23* VDR_23849224_ChIP-Seq_CD4+_Human2.22940262
24NELFA_20434984_ChIP-Seq_ESCs_Mouse2.17098294
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.06993167
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.06118594
27* GABP_19822575_ChIP-Seq_HepG2_Human2.01335960
28MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.98513489
29TTF2_22483619_ChIP-Seq_HELA_Human1.97806653
30* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.97275786
31* FOXP3_21729870_ChIP-Seq_TREG_Human1.95763631
32MYCN_18555785_ChIP-Seq_MESCs_Mouse1.95322596
33NANOG_18555785_ChIP-Seq_MESCs_Mouse1.95279841
34POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.93277190
35THAP11_20581084_ChIP-Seq_MESCs_Mouse1.92101443
36NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.88464598
37AR_21909140_ChIP-Seq_LNCAP_Human1.87372876
38DCP1A_22483619_ChIP-Seq_HELA_Human1.83507936
39YY1_21170310_ChIP-Seq_MESCs_Mouse1.83167162
40CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.74669357
41TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71586406
42E2F1_21310950_ChIP-Seq_MCF-7_Human1.67135969
43KDM5A_27292631_Chip-Seq_BREAST_Human1.56866325
44NOTCH1_21737748_ChIP-Seq_TLL_Human1.56558624
45YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56241097
46CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.53084258
47ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.52183063
48CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.49352700
49SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.47100307
50PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46983931
51FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.46393160
52SRF_21415370_ChIP-Seq_HL-1_Mouse1.43775086
53KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.42071442
54SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.39810881
55PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.37671415
56TET1_21451524_ChIP-Seq_MESCs_Mouse1.36214760
57* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.32546412
58POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.32364834
59FOXP1_21924763_ChIP-Seq_HESCs_Human1.31996487
60CTCF_26484167_Chip-Seq_Bcells_Mouse1.31554840
61POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.30486591
62YY1_22570637_ChIP-Seq_MALME-3M_Human1.30134269
63* ELK1_19687146_ChIP-ChIP_HELA_Human1.29946208
64KLF4_18555785_ChIP-Seq_MESCs_Mouse1.28714214
65SA1_27219007_Chip-Seq_Bcells_Human1.27966311
66TP63_19390658_ChIP-ChIP_HaCaT_Human1.27422934
67FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.26878635
68CTCF_18555785_ChIP-Seq_MESCs_Mouse1.25757579
69DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.25508755
70MYC_22102868_ChIP-Seq_BL_Human1.24785528
71* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.24655977
72ZFX_18555785_ChIP-Seq_MESCs_Mouse1.24494243
73CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.22654849
74TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.21314773
75MYC_18940864_ChIP-ChIP_HL60_Human1.21077521
76SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.20535566
77TBX5_21415370_ChIP-Seq_HL-1_Mouse1.20149284
78MAF_26560356_Chip-Seq_TH2_Human1.19735558
79SOX2_18555785_ChIP-Seq_MESCs_Mouse1.18507633
80EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.18094936
81P68_20966046_ChIP-Seq_HELA_Human1.17750398
82STAT1_20625510_ChIP-Seq_HELA_Human1.15210974
83SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.13578703
84PHF8_20622854_ChIP-Seq_HELA_Human1.13481302
85* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.13462492
86ELF1_20517297_ChIP-Seq_JURKAT_Human1.13288534
87CIITA_25753668_ChIP-Seq_RAJI_Human1.12777347
88NANOG_21062744_ChIP-ChIP_HESCs_Human1.11804032
89SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.09220959
90RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.08534407
91ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.07885488
92E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07832368
93BCL6_27268052_Chip-Seq_Bcells_Human1.07081140
94* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.06846296
95KAP1_22055183_ChIP-Seq_ESCs_Mouse1.06820713
96ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.06738668
97RARB_24833708_ChIP-Seq_LIVER_Mouse1.06714907
98SRY_22984422_ChIP-ChIP_TESTIS_Rat1.05855595
99ETS1_21867929_ChIP-Seq_TH2_Mouse1.05521239
100* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.04717339
101NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.02931068
102NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.02632079
103PU.1_20513432_ChIP-Seq_Bcells_Mouse1.02266927
104TP53_22573176_ChIP-Seq_HFKS_Human1.01624559
105CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.01421973
106CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.00165938
107STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99742350
108FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99008620
109* BCOR_27268052_Chip-Seq_Bcells_Human0.98773248
110NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.98335455
111ZNF274_21170338_ChIP-Seq_K562_Hela0.97406541
112ERG_20887958_ChIP-Seq_HPC-7_Mouse0.97347872
113CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.97294933
114IRF1_19129219_ChIP-ChIP_H3396_Human0.96913062
115* CTCF_21964334_Chip-Seq_Bcells_Human0.95814166
116DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.95318796
117SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.95097770
118PADI4_21655091_ChIP-ChIP_MCF-7_Human0.94213238
119* CTCF_21964334_ChIP-Seq_BJAB-B_Human0.92262180
120KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.92028907
121KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.90742770
122PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.89896980
123ELF1_17652178_ChIP-ChIP_JURKAT_Human0.89763952
124BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.89210604
125CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.88199322
126ELK1_22589737_ChIP-Seq_MCF10A_Human0.86582165
127TFEB_21752829_ChIP-Seq_HELA_Human0.85168274
128SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.85092760
129KAP1_27257070_Chip-Seq_ESCs_Mouse0.84564320
130KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.83690786
131KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.83690786
132KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.83690786
133POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.82322473
134SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.81286511
135RBPJ_22232070_ChIP-Seq_NCS_Mouse0.80777273
136SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.76691534
137VDR_21846776_ChIP-Seq_THP-1_Human0.76329208

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.04095173
2MP0003111_abnormal_nucleus_morphology4.79169039
3MP0010094_abnormal_chromosome_stability4.67723930
4MP0004957_abnormal_blastocyst_morpholog4.13137670
5MP0005408_hypopigmentation4.12181016
6MP0003077_abnormal_cell_cycle3.91981486
7MP0008877_abnormal_DNA_methylation3.83136473
8MP0004147_increased_porphyrin_level3.77172378
9MP0006292_abnormal_olfactory_placode3.27148372
10MP0003718_maternal_effect3.21001948
11MP0008057_abnormal_DNA_replication3.18017628
12MP0008058_abnormal_DNA_repair3.02042818
13MP0008007_abnormal_cellular_replicative2.88035591
14MP0000750_abnormal_muscle_regeneration2.84603973
15MP0000371_diluted_coat_color2.62556023
16MP0008932_abnormal_embryonic_tissue2.58570139
17MP0003186_abnormal_redox_activity2.48061713
18MP0000013_abnormal_adipose_tissue2.47612204
19MP0003786_premature_aging2.47330394
20MP0002938_white_spotting2.42890630
21MP0002837_dystrophic_cardiac_calcinosis2.25813696
22MP0006036_abnormal_mitochondrial_physio2.19904690
23MP0001661_extended_life_span2.14586246
24MP0001929_abnormal_gametogenesis2.11553416
25MP0000566_synostosis2.06475954
26MP0002210_abnormal_sex_determination2.03431819
27MP0002653_abnormal_ependyma_morphology2.01358342
28MP0009697_abnormal_copulation2.01307729
29MP0000350_abnormal_cell_proliferation2.00084867
30MP0004145_abnormal_muscle_electrophysio1.96396517
31MP0005646_abnormal_pituitary_gland1.96339664
32MP0003315_abnormal_perineum_morphology1.94201053
33MP0002102_abnormal_ear_morphology1.93283687
34MP0002396_abnormal_hematopoietic_system1.89342836
35MP0002254_reproductive_system_inflammat1.88734130
36MP0001730_embryonic_growth_arrest1.82692741
37MP0003123_paternal_imprinting1.76566404
38MP0005058_abnormal_lysosome_morphology1.75381510
39MP0010307_abnormal_tumor_latency1.70486974
40MP0008260_abnormal_autophagy1.68995123
41MP0000490_abnormal_crypts_of1.65670693
42MP0001672_abnormal_embryogenesis/_devel1.64539527
43MP0005380_embryogenesis_phenotype1.64539527
44MP0001145_abnormal_male_reproductive1.64488172
45MP0000653_abnormal_sex_gland1.64405841
46MP0001764_abnormal_homeostasis1.60926903
47MP0000747_muscle_weakness1.59101202
48MP0002075_abnormal_coat/hair_pigmentati1.54080268
49MP0001986_abnormal_taste_sensitivity1.53609039
50MP0005410_abnormal_fertilization1.53539494
51MP0001727_abnormal_embryo_implantation1.52422274
52MP0003806_abnormal_nucleotide_metabolis1.52250697
53MP0001697_abnormal_embryo_size1.51756401
54MP0001324_abnormal_eye_pigmentation1.48428822
55MP0001119_abnormal_female_reproductive1.48424864
56MP0002085_abnormal_embryonic_tissue1.46133850
57MP0002269_muscular_atrophy1.43431258
58MP0002160_abnormal_reproductive_system1.38182614
59MP0009333_abnormal_splenocyte_physiolog1.36518379
60MP0002736_abnormal_nociception_after1.36162472
61MP0003698_abnormal_male_reproductive1.32339949
62MP0002080_prenatal_lethality1.30163812
63MP0002019_abnormal_tumor_incidence1.29121026
64MP0003984_embryonic_growth_retardation1.26375322
65MP0001944_abnormal_pancreas_morphology1.25441416
66MP0000313_abnormal_cell_death1.24597347
67MP0001529_abnormal_vocalization1.24434655
68MP0001188_hyperpigmentation1.20500285
69MP0002088_abnormal_embryonic_growth/wei1.20307591
70MP0003699_abnormal_female_reproductive1.17933039
71MP0002161_abnormal_fertility/fecundity1.17256850
72MP0004808_abnormal_hematopoietic_stem1.16950930
73MP0002084_abnormal_developmental_patter1.16710136
74MP0003121_genomic_imprinting1.16691175
75MP0000749_muscle_degeneration1.15195120
76MP0009250_abnormal_appendicular_skeleto1.14903687
77MP0001968_abnormal_touch/_nociception1.13309363
78MP0003011_delayed_dark_adaptation1.12353601
79MP0003329_amyloid_beta_deposits1.11881603
80MP0000015_abnormal_ear_pigmentation1.11195327
81MP0003937_abnormal_limbs/digits/tail_de1.10290127
82MP0003221_abnormal_cardiomyocyte_apopto1.10178806
83MP0001186_pigmentation_phenotype1.09723478
84MP0003119_abnormal_digestive_system1.07679757
85MP0010030_abnormal_orbit_morphology1.07364915
86MP0008995_early_reproductive_senescence1.06643693
87MP0004885_abnormal_endolymph1.06574709
88MP0002086_abnormal_extraembryonic_tissu1.02577341
89MP0003646_muscle_fatigue1.02437281
90MP0001545_abnormal_hematopoietic_system1.02421580
91MP0005397_hematopoietic_system_phenotyp1.02421580
92MP0006276_abnormal_autonomic_nervous1.01056803
93MP0009840_abnormal_foam_cell0.97615013
94MP0002249_abnormal_larynx_morphology0.97348366
95MP0002638_abnormal_pupillary_reflex0.96216357
96MP0001293_anophthalmia0.95841764
97MP0005389_reproductive_system_phenotype0.94833025
98MP0003890_abnormal_embryonic-extraembry0.94046462
99MP0002751_abnormal_autonomic_nervous0.93904584
100MP0005253_abnormal_eye_physiology0.93567077
101MP0002398_abnormal_bone_marrow0.92751714
102MP0001502_abnormal_circadian_rhythm0.92255284
103MP0005197_abnormal_uvea_morphology0.92221829
104MP0000631_abnormal_neuroendocrine_gland0.91312686
105MP0004233_abnormal_muscle_weight0.90415530
106MP0003787_abnormal_imprinting0.90010572
107MP0000689_abnormal_spleen_morphology0.87928948
108MP0000604_amyloidosis0.87704160
109MP0000703_abnormal_thymus_morphology0.85664924
110MP0002089_abnormal_postnatal_growth/wei0.84685242
111MP0004142_abnormal_muscle_tone0.84340527
112MP0005083_abnormal_biliary_tract0.83815497
113MP0002877_abnormal_melanocyte_morpholog0.83786431
114MP0000759_abnormal_skeletal_muscle0.82073623
115MP0005395_other_phenotype0.80285363
116MP0000049_abnormal_middle_ear0.80268104
117MP0002332_abnormal_exercise_endurance0.79313763
118MP0006054_spinal_hemorrhage0.78126450
119MP0005621_abnormal_cell_physiology0.77997282
120MP0000358_abnormal_cell_content/0.77650050
121MP0005647_abnormal_sex_gland0.77577746
122MP0005332_abnormal_amino_acid0.77555447
123MP0003567_abnormal_fetal_cardiomyocyte0.76995219
124MP0003136_yellow_coat_color0.76652838
125MP0005360_urolithiasis0.75723506
126MP0005174_abnormal_tail_pigmentation0.75707570
127MP0003656_abnormal_erythrocyte_physiolo0.75308700
128MP0005384_cellular_phenotype0.75300690
129MP0004185_abnormal_adipocyte_glucose0.75131878
130MP0000751_myopathy0.75107151
131MP0000372_irregular_coat_pigmentation0.74145854
132MP0002295_abnormal_pulmonary_circulatio0.74016362
133MP0003861_abnormal_nervous_system0.73208302
134MP0003938_abnormal_ear_development0.73117061
135MP0002693_abnormal_pancreas_physiology0.72147043
136MP0002722_abnormal_immune_system0.70740097
137MP0004133_heterotaxia0.70656165
138MP0005075_abnormal_melanosome_morpholog0.69585887
139MP0002184_abnormal_innervation0.68506924
140MP0005167_abnormal_blood-brain_barrier0.68495941
141MP0005266_abnormal_metabolism0.68010082
142MP0000858_altered_metastatic_potential0.67732809
143MP0005367_renal/urinary_system_phenotyp0.67558489
144MP0000516_abnormal_urinary_system0.67558489
145MP0004130_abnormal_muscle_cell0.67308644
146MP0008872_abnormal_physiological_respon0.66411203
147MP0000003_abnormal_adipose_tissue0.65977872
148MP0005670_abnormal_white_adipose0.65587423
149MP0003183_abnormal_peptide_metabolism0.65506416
150MP0002429_abnormal_blood_cell0.64735834
151MP0002277_abnormal_respiratory_mucosa0.64582363
152MP0001286_abnormal_eye_development0.62168424
153MP0004197_abnormal_fetal_growth/weight/0.61456108
154MP0001919_abnormal_reproductive_system0.60972395
155MP0006035_abnormal_mitochondrial_morpho0.60903083
156MP0005394_taste/olfaction_phenotype0.57567124
157MP0005499_abnormal_olfactory_system0.57567124
158MP0002009_preneoplasia0.56873253
159MP0005451_abnormal_body_composition0.56868421
160MP0002114_abnormal_axial_skeleton0.55883269
161MP0005076_abnormal_cell_differentiation0.53925771
162MP0002177_abnormal_outer_ear0.52873367
163MP0000716_abnormal_immune_system0.52872126
164MP0003936_abnormal_reproductive_system0.52129497
165MP0002282_abnormal_trachea_morphology0.52013295
166MP0009672_abnormal_birth_weight0.51796319
167MP0008789_abnormal_olfactory_epithelium0.50720130
168MP0002095_abnormal_skin_pigmentation0.50114487

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of alanine metabolism (HP:0010916)5.80789426
2Hyperalaninemia (HP:0003348)5.80789426
3Abnormality of pyruvate family amino acid metabolism (HP:0010915)5.80789426
4IgM deficiency (HP:0002850)5.17888586
5Birth length less than 3rd percentile (HP:0003561)5.15984187
6Breast hypoplasia (HP:0003187)4.57280977
7Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.45820930
8Decreased activity of mitochondrial respiratory chain (HP:0008972)4.45820930
9Abnormal mitochondria in muscle tissue (HP:0008316)4.41918889
10Chromosomal breakage induced by crosslinking agents (HP:0003221)4.35629623
11Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)4.23420605
12Increased intramyocellular lipid droplets (HP:0012240)4.22977644
13Abnormality of the labia minora (HP:0012880)3.99406375
14Chromsome breakage (HP:0040012)3.99189615
15Increased muscle lipid content (HP:0009058)3.86895299
16Carpal bone hypoplasia (HP:0001498)3.71672337
17Impulsivity (HP:0100710)3.68532162
18Mitochondrial inheritance (HP:0001427)3.65062800
19Hepatocellular necrosis (HP:0001404)3.64712933
20Cerebral hypomyelination (HP:0006808)3.52383551
21Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.51860993
22Esophageal neoplasm (HP:0100751)3.51625313
23Neoplasm of head and neck (HP:0012288)3.51625313
24Patellar aplasia (HP:0006443)3.51460151
25Fibular aplasia (HP:0002990)3.50513111
26Acute necrotizing encephalopathy (HP:0006965)3.46967240
27Ragged-red muscle fibers (HP:0003200)3.44778757
28Reticulocytopenia (HP:0001896)3.39145374
29Increased CSF lactate (HP:0002490)3.35990549
30Hypoplastic pelvis (HP:0008839)3.32759920
31Aplasia/hypoplasia of the uterus (HP:0008684)3.31955349
32Aplasia/Hypoplasia of the patella (HP:0006498)3.26890505
33Progressive external ophthalmoplegia (HP:0000590)3.24830026
34Abnormality of cells of the erythroid lineage (HP:0012130)3.22216271
35Oligodactyly (hands) (HP:0001180)3.19104839
36Abnormal number of erythroid precursors (HP:0012131)3.15264212
37Supernumerary spleens (HP:0009799)3.15125168
38Hepatic necrosis (HP:0002605)3.14230408
39Aplastic anemia (HP:0001915)3.13639674
40Abnormality of the preputium (HP:0100587)3.11412995
41Meckel diverticulum (HP:0002245)3.11240364
42Synostosis involving the elbow (HP:0003938)3.10010651
43Humeroradial synostosis (HP:0003041)3.10010651
44Muscle fiber atrophy (HP:0100295)3.07384893
45Abnormality of the ileum (HP:0001549)2.98835725
46Oligodactyly (HP:0012165)2.96987916
47Acute encephalopathy (HP:0006846)2.96555239
48Premature ovarian failure (HP:0008209)2.95544464
49IgG deficiency (HP:0004315)2.94997771
50Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.94825229
51Breast aplasia (HP:0100783)2.94214486
52Abnormality of chromosome stability (HP:0003220)2.91171629
53Aplasia/Hypoplasia of the breasts (HP:0010311)2.89093213
54Type 2 muscle fiber atrophy (HP:0003554)2.87885628
55Oral leukoplakia (HP:0002745)2.84796667
56Absent radius (HP:0003974)2.84029800
57Horseshoe kidney (HP:0000085)2.76601819
58Increased serum lactate (HP:0002151)2.75424794
59Lactic acidosis (HP:0003128)2.74954446
603-Methylglutaconic aciduria (HP:0003535)2.73795423
61Albinism (HP:0001022)2.72890316
62Facial hemangioma (HP:0000329)2.71033149
63Rough bone trabeculation (HP:0100670)2.70690661
64Progressive macrocephaly (HP:0004481)2.70280112
65Aplasia involving forearm bones (HP:0009822)2.68526863
66Absent forearm bone (HP:0003953)2.68526863
67Exercise intolerance (HP:0003546)2.68103165
68Aplasia/Hypoplasia of the uvula (HP:0010293)2.66651704
69Male infertility (HP:0003251)2.62908812
70Abnormality of the phalanges of the hallux (HP:0010057)2.62027452
71Myelodysplasia (HP:0002863)2.61537058
72Sloping forehead (HP:0000340)2.61488581
73Abnormal finger flexion creases (HP:0006143)2.61263224
74Sparse lateral eyebrow (HP:0005338)2.57425269
75Myopathic facies (HP:0002058)2.56926766
76Acute lymphatic leukemia (HP:0006721)2.55156783
77Delayed epiphyseal ossification (HP:0002663)2.54180623
78Increased hepatocellular lipid droplets (HP:0006565)2.53664320
79Cleft eyelid (HP:0000625)2.53485964
80Lipid accumulation in hepatocytes (HP:0006561)2.53166540
81Tongue fasciculations (HP:0001308)2.53003127
82Abnormal spermatogenesis (HP:0008669)2.52939935
83Split foot (HP:0001839)2.52242677
84Posterior subcapsular cataract (HP:0007787)2.51977892
85Degeneration of anterior horn cells (HP:0002398)2.51563859
86Abnormality of the anterior horn cell (HP:0006802)2.51563859
87Secondary amenorrhea (HP:0000869)2.50815818
88Hypoplasia of the capital femoral epiphysis (HP:0003090)2.50666925
89IgA deficiency (HP:0002720)2.42831624
90Rhabdomyosarcoma (HP:0002859)2.35788196
91Small intestinal stenosis (HP:0012848)2.35657785
92Duodenal stenosis (HP:0100867)2.35657785
93Absent thumb (HP:0009777)2.34277170
94Gastrointestinal stroma tumor (HP:0100723)2.33743478
95Neck muscle weakness (HP:0000467)2.33306462
96Triphalangeal thumb (HP:0001199)2.32841631
97Adactyly (HP:0009776)2.31258763
98Axonal loss (HP:0003447)2.31111779
99Duplicated collecting system (HP:0000081)2.30370380
100Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.29564615
101Oligomenorrhea (HP:0000876)2.25407835
102Infertility (HP:0000789)2.25267911
103Abnormality of serum amino acid levels (HP:0003112)2.23947521
104Renal Fanconi syndrome (HP:0001994)2.23827714
105Cerebral edema (HP:0002181)2.22261326
106Muscle fibrillation (HP:0010546)2.20467166
107Medulloblastoma (HP:0002885)2.20259804
108Pallor (HP:0000980)2.16595604
109Irregular epiphyses (HP:0010582)2.15440617
110Tracheoesophageal fistula (HP:0002575)2.13316464
111Symphalangism affecting the phalanges of the hand (HP:0009773)2.11917011
112Macrocytic anemia (HP:0001972)2.10792024
113Bone marrow hypocellularity (HP:0005528)2.10755310
114CNS hypomyelination (HP:0003429)2.09458138
115Abnormality of T cell physiology (HP:0011840)2.08878229
116Abnormality of B cell number (HP:0010975)2.05690559
117B lymphocytopenia (HP:0010976)2.05690559
118Unsteady gait (HP:0002317)2.05660279
119Abnormality of the carotid arteries (HP:0005344)2.05077186
120Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.04986462
121Aplasia/hypoplasia of the humerus (HP:0006507)2.04717971
122Premature graying of hair (HP:0002216)2.04466321
123Abnormality of DNA repair (HP:0003254)2.04398792
124Recurrent sinusitis (HP:0011108)2.03231520
125Abnormality of the heme biosynthetic pathway (HP:0010472)2.02713843
126Short thumb (HP:0009778)2.02366177
127Personality changes (HP:0000751)2.02262768
128Spinal muscular atrophy (HP:0007269)2.01212419
129Cortical dysplasia (HP:0002539)1.99883616
130Agnosia (HP:0010524)1.99069634
131Squamous cell carcinoma (HP:0002860)1.98852707
132Ectopic kidney (HP:0000086)1.97528675
133Shawl scrotum (HP:0000049)1.97112927
134Delusions (HP:0000746)1.96808920
135Rib fusion (HP:0000902)1.95675990
136Abnormality of the renal collecting system (HP:0004742)1.94055890
137Abnormal lung lobation (HP:0002101)1.93867660
138Abnormal trabecular bone morphology (HP:0100671)1.93490803
139Pancreatic cysts (HP:0001737)1.92324149
140Increased serum pyruvate (HP:0003542)1.91592661
141Slender long bone (HP:0003100)1.90768375
142Selective tooth agenesis (HP:0001592)1.90117893
143Respiratory failure (HP:0002878)1.90089962
144Abnormality of the proximal phalanges of the hand (HP:0009834)1.89776045
145Pancreatic fibrosis (HP:0100732)1.88372649
146Abnormality of the aortic arch (HP:0012303)1.87955855
147Constricted visual fields (HP:0001133)1.87707022
148Capillary hemangiomas (HP:0005306)1.87552970
149Methylmalonic aciduria (HP:0012120)1.87327737
150Abnormality of the costochondral junction (HP:0000919)1.87104959
151Abnormal hemoglobin (HP:0011902)1.86449455
152Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.86085748
153Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.85107877
154Absent epiphyses (HP:0010577)1.85107877
155Hemivertebrae (HP:0002937)1.84922006
156Abnormal hair whorl (HP:0010721)1.84124361
157Stomatitis (HP:0010280)1.83206292
158Type II lissencephaly (HP:0007260)1.82567851
159Poor suck (HP:0002033)1.81747661
160Microretrognathia (HP:0000308)1.81306755
161Abnormality of the duodenum (HP:0002246)1.80849309
162Pulmonary fibrosis (HP:0002206)1.79542090
163Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.79095837
164Nemaline bodies (HP:0003798)1.78453364
165Abnormality of homocysteine metabolism (HP:0010919)1.77939753
166Homocystinuria (HP:0002156)1.77939753
167Self-mutilation (HP:0000742)1.77450558
168Optic disc pallor (HP:0000543)1.77193498
169Cellular immunodeficiency (HP:0005374)1.76903428
170Muscle fiber inclusion bodies (HP:0100299)1.76771540
171Duplication of thumb phalanx (HP:0009942)1.75609269
172Mesangial abnormality (HP:0001966)1.75461203
173Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.74142908
174Abnormal protein N-linked glycosylation (HP:0012347)1.74142908
175Abnormal protein glycosylation (HP:0012346)1.74142908
176Abnormal glycosylation (HP:0012345)1.74142908
177Pancytopenia (HP:0001876)1.72338779
178Flat capital femoral epiphysis (HP:0003370)1.71907067
179Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.71881116
180Progressive muscle weakness (HP:0003323)1.70879082
181Abnormality of glycolysis (HP:0004366)1.70527948
182Dicarboxylic aciduria (HP:0003215)1.69855287
183Abnormality of dicarboxylic acid metabolism (HP:0010995)1.69855287
184CNS demyelination (HP:0007305)1.69756321
185Polyphagia (HP:0002591)1.68697021
186Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.67660313
187Neutropenia (HP:0001875)1.67142420
188Type I transferrin isoform profile (HP:0003642)1.66633512

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.69926901
2SCYL23.52745865
3NEK23.49886568
4MAP4K23.08680070
5BCKDK3.07452427
6EIF2AK13.07242063
7WEE13.05103996
8SRPK13.04001470
9CSNK1G13.01652119
10MAP3K62.95836944
11CDC72.79886708
12MAP3K92.74361000
13MAP3K132.71498746
14CSNK1G32.46032064
15MAPK112.29312031
16TLK12.28768157
17NME22.24994449
18CSNK1A1L2.13484081
19LATS22.13252072
20TTK2.13066489
21ACVR1B2.11946956
22ZAK2.10059481
23PLK42.09828987
24CHEK21.96334836
25MKNK21.93801226
26AKT31.92201832
27PLK11.92051286
28STK38L1.88408906
29TESK21.80422696
30CSNK1G21.79575930
31STK161.68177550
32DYRK31.66239240
33KSR21.60057168
34TSSK61.56663749
35BMPR21.54065639
36VRK11.49499106
37MAP2K31.48786597
38CDK81.47911439
39CDK71.46661380
40CDK41.46126577
41NLK1.43419676
42JAK31.43271908
43YES11.38505809
44OBSCN1.37631486
45AURKB1.35586398
46DYRK21.34395061
47MKNK11.33932794
48BRAF1.29684020
49AURKA1.27786029
50PHKG21.26909741
51PHKG11.26909741
52ATR1.26729938
53PLK31.19593458
54EIF2AK31.19532394
55CDK191.11521512
56BRSK21.09406539
57TRIM281.07037129
58PRKD31.04759980
59CCNB11.02574693
60CDK31.00948786
61BRSK11.00447918
62LIMK10.99380329
63CSK0.99323093
64IKBKE0.96129804
65MUSK0.94411534
66CHEK10.92078878
67CASK0.91414502
68CDK120.90164620
69TBK10.90056008
70BRD40.88184834
71MAP3K30.88154748
72PDK40.85832577
73PDK30.85832577
74ADRBK20.85156386
75DYRK1A0.84681563
76INSRR0.82372269
77PRKCI0.81664936
78PIM20.81341277
79MOS0.81321676
80MAP3K10.81132010
81SGK4940.80015554
82SGK2230.80015554
83PAK10.79687555
84LATS10.79296276
85ARAF0.78711127
86TAOK20.75979293
87CDK20.72126136
88STK30.70964469
89MAP2K70.70667542
90PRKCG0.68400309
91GRK50.67086921
92SYK0.66848650
93MAP3K120.65875493
94VRK20.65341145
95NEK10.65264766
96PRPF4B0.64784357
97ATM0.64518124
98MAP2K10.64298997
99PIM10.63250483
100RPS6KA50.62162759
101EEF2K0.59906257
102TIE10.59377360
103ERBB40.58087035
104MAP3K110.58079441
105MAP3K80.56927488
106DYRK1B0.56686287
107RPS6KB20.54809338
108EIF2AK20.54772160
109CSNK1A10.53847089
110FLT30.53400016
111KSR10.53181346
112ADRBK10.53161334
113MAPK120.52784438
114DDR20.52757718
115STK380.51369523
116CDK90.50635585
117CDK10.50371331
118CSNK2A10.50189837
119ABL20.49092793
120MAP3K40.48724182
121CDK11A0.48504342
122RAF10.48067931
123CSNK2A20.47864632
124RIPK40.47415844
125STK100.47383166
126CDK60.46703609
127TEC0.44890206
128PDK20.44396078
129EPHA20.43740507
130LCK0.43715968
131CDK150.43162514
132CDK180.42638119
133ALK0.42549321
134MATK0.42286213
135PBK0.41791837
136NME10.41148975
137PAK60.40962423
138TAOK10.40387729
139PLK20.39980033
140KIT0.39911698
141AKT20.39844231
142MAP2K40.38974111
143PRKD20.38582324
144NTRK20.37864837
145GRK10.37340540
146TESK10.36090422
147WNK30.35942334
148CDK140.35278477
149EPHB20.33588975
150TYRO30.33445706
151IKBKB0.32991077
152MAPK90.32648639
153DAPK10.32602984
154FGR0.32297469
155EPHA30.31397751
156IRAK30.28506415
157SGK20.27561118

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.46487093
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.24133999
3RNA polymerase_Homo sapiens_hsa030204.21688731
4Oxidative phosphorylation_Homo sapiens_hsa001903.94717250
5Mismatch repair_Homo sapiens_hsa034303.33759755
6Homologous recombination_Homo sapiens_hsa034403.32125074
7Vitamin B6 metabolism_Homo sapiens_hsa007503.19112682
8Parkinsons disease_Homo sapiens_hsa050123.14103961
9Nucleotide excision repair_Homo sapiens_hsa034203.04497973
10RNA transport_Homo sapiens_hsa030132.98678018
11Base excision repair_Homo sapiens_hsa034102.92113770
12Cell cycle_Homo sapiens_hsa041102.90296811
13Basal transcription factors_Homo sapiens_hsa030222.87468407
14Spliceosome_Homo sapiens_hsa030402.79151479
15Ribosome_Homo sapiens_hsa030102.78594288
16Fanconi anemia pathway_Homo sapiens_hsa034602.65426214
17Proteasome_Homo sapiens_hsa030502.58405636
18Pyrimidine metabolism_Homo sapiens_hsa002402.40777762
19Sulfur metabolism_Homo sapiens_hsa009202.40593878
20Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.31590158
21Collecting duct acid secretion_Homo sapiens_hsa049662.28206997
22Alzheimers disease_Homo sapiens_hsa050102.24877971
23RNA degradation_Homo sapiens_hsa030181.87058936
24One carbon pool by folate_Homo sapiens_hsa006701.81296257
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.78387406
26Steroid biosynthesis_Homo sapiens_hsa001001.75859422
27Oocyte meiosis_Homo sapiens_hsa041141.65108819
28Non-homologous end-joining_Homo sapiens_hsa034501.64297166
29Purine metabolism_Homo sapiens_hsa002301.62786572
30mRNA surveillance pathway_Homo sapiens_hsa030151.61864989
31p53 signaling pathway_Homo sapiens_hsa041151.60174290
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.50332344
33Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.44998189
34Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.39201586
35Cardiac muscle contraction_Homo sapiens_hsa042601.38277848
36Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.36081975
37Arginine biosynthesis_Homo sapiens_hsa002201.31266108
38Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.30401178
39Sulfur relay system_Homo sapiens_hsa041221.28323655
40Nitrogen metabolism_Homo sapiens_hsa009101.23437722
412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.22083063
42Epstein-Barr virus infection_Homo sapiens_hsa051691.19331360
43Fatty acid elongation_Homo sapiens_hsa000621.17268149
44Pentose phosphate pathway_Homo sapiens_hsa000301.16823890
45Vibrio cholerae infection_Homo sapiens_hsa051101.08899451
46Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.07016656
47SNARE interactions in vesicular transport_Homo sapiens_hsa041300.95284604
48Synaptic vesicle cycle_Homo sapiens_hsa047210.95102686
49Peroxisome_Homo sapiens_hsa041460.91347802
50Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.86632762
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.85627299
52Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.84435535
53Arginine and proline metabolism_Homo sapiens_hsa003300.83119754
54Maturity onset diabetes of the young_Homo sapiens_hsa049500.82654868
55Ether lipid metabolism_Homo sapiens_hsa005650.81637244
56Biosynthesis of amino acids_Homo sapiens_hsa012300.81603100
57Cysteine and methionine metabolism_Homo sapiens_hsa002700.81226435
58Carbon metabolism_Homo sapiens_hsa012000.77831063
59Herpes simplex infection_Homo sapiens_hsa051680.76246046
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74711007
61Shigellosis_Homo sapiens_hsa051310.73467699
62Galactose metabolism_Homo sapiens_hsa000520.73283988
63Viral carcinogenesis_Homo sapiens_hsa052030.69375903
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.68989026
65Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.68562844
66Cyanoamino acid metabolism_Homo sapiens_hsa004600.67904692
67Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.61817104
68Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.61280501
69Folate biosynthesis_Homo sapiens_hsa007900.60763347
70Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.59199292
71Systemic lupus erythematosus_Homo sapiens_hsa053220.59088887
72Regulation of autophagy_Homo sapiens_hsa041400.58824345
73Vitamin digestion and absorption_Homo sapiens_hsa049770.58570619
74HTLV-I infection_Homo sapiens_hsa051660.58249627
75Butanoate metabolism_Homo sapiens_hsa006500.56374568
76GABAergic synapse_Homo sapiens_hsa047270.56042753
77Huntingtons disease_Homo sapiens_hsa050160.52608430
78Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49853639
79Nicotine addiction_Homo sapiens_hsa050330.49431457
80Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.49198136
81Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.49170397
82Lysosome_Homo sapiens_hsa041420.47052443
83Other glycan degradation_Homo sapiens_hsa005110.45724585
84Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.45496742
85Antigen processing and presentation_Homo sapiens_hsa046120.45376839
86Graft-versus-host disease_Homo sapiens_hsa053320.44971878
87Fructose and mannose metabolism_Homo sapiens_hsa000510.43963630
88MicroRNAs in cancer_Homo sapiens_hsa052060.43402042
89Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.42275088
90Thyroid cancer_Homo sapiens_hsa052160.41990790
91Intestinal immune network for IgA production_Homo sapiens_hsa046720.36187652
92T cell receptor signaling pathway_Homo sapiens_hsa046600.35399352
93Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.34520328
94Primary bile acid biosynthesis_Homo sapiens_hsa001200.34264733
95TGF-beta signaling pathway_Homo sapiens_hsa043500.34174852
96Glutathione metabolism_Homo sapiens_hsa004800.33464738
97Arachidonic acid metabolism_Homo sapiens_hsa005900.33334751
98HIF-1 signaling pathway_Homo sapiens_hsa040660.33294835
99Bladder cancer_Homo sapiens_hsa052190.32258348
100Fatty acid metabolism_Homo sapiens_hsa012120.32013860
101Transcriptional misregulation in cancer_Homo sapiens_hsa052020.31327751
102Primary immunodeficiency_Homo sapiens_hsa053400.30780875
103Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.30351920
104Linoleic acid metabolism_Homo sapiens_hsa005910.30041629
105Morphine addiction_Homo sapiens_hsa050320.29592400
106Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.28880195
107Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.28327827
108Caffeine metabolism_Homo sapiens_hsa002320.27884661
109Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.27443923
110Pyruvate metabolism_Homo sapiens_hsa006200.27354052
111Prion diseases_Homo sapiens_hsa050200.26988278
112Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.26849447
113Glycerophospholipid metabolism_Homo sapiens_hsa005640.24474490
114Rheumatoid arthritis_Homo sapiens_hsa053230.23993446
115Colorectal cancer_Homo sapiens_hsa052100.23050246
116Hepatitis B_Homo sapiens_hsa051610.23008954
117Propanoate metabolism_Homo sapiens_hsa006400.22809844
118Acute myeloid leukemia_Homo sapiens_hsa052210.22174704
119Protein export_Homo sapiens_hsa030600.21133233
120Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.20934156
121Hippo signaling pathway_Homo sapiens_hsa043900.20172568
122Selenocompound metabolism_Homo sapiens_hsa004500.20170773
123Hedgehog signaling pathway_Homo sapiens_hsa043400.19803408
124Apoptosis_Homo sapiens_hsa042100.19419808
125VEGF signaling pathway_Homo sapiens_hsa043700.18593550
126Phototransduction_Homo sapiens_hsa047440.18074416
127Ovarian steroidogenesis_Homo sapiens_hsa049130.17866270
128alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.17255711
129Wnt signaling pathway_Homo sapiens_hsa043100.15255258
130mTOR signaling pathway_Homo sapiens_hsa041500.14277516
131Notch signaling pathway_Homo sapiens_hsa043300.13987869
132Alcoholism_Homo sapiens_hsa050340.13953442
133Metabolic pathways_Homo sapiens_hsa011000.13890499
134NOD-like receptor signaling pathway_Homo sapiens_hsa046210.13608903
135Pathways in cancer_Homo sapiens_hsa052000.12381752
136Measles_Homo sapiens_hsa051620.12139802
137Melanoma_Homo sapiens_hsa052180.12023775
138Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.11267356
139Thyroid hormone signaling pathway_Homo sapiens_hsa049190.11193626
140Inositol phosphate metabolism_Homo sapiens_hsa005620.10930833
141Longevity regulating pathway - mammal_Homo sapiens_hsa042110.10502226
142NF-kappa B signaling pathway_Homo sapiens_hsa040640.09559627
143Small cell lung cancer_Homo sapiens_hsa052220.09430542
144Regulation of actin cytoskeleton_Homo sapiens_hsa048100.09143368
145Chronic myeloid leukemia_Homo sapiens_hsa052200.09119684
146Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.08819694
147N-Glycan biosynthesis_Homo sapiens_hsa005100.08416259
148Sphingolipid metabolism_Homo sapiens_hsa006000.06183006
149Influenza A_Homo sapiens_hsa051640.06079747
150FoxO signaling pathway_Homo sapiens_hsa040680.06018455
151Non-small cell lung cancer_Homo sapiens_hsa052230.05902651
152Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.05568278
153ErbB signaling pathway_Homo sapiens_hsa040120.05151794

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