BRF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of the three subunits of the RNA polymerase III transcription factor complex. This complex plays a central role in transcription initiation by RNA polymerase III on genes encoding tRNA, 5S rRNA, and other small structural RNAs. The gene product belongs to the TF2B family. Several alternatively spliced variants encoding different isoforms, that function at different promoters transcribed by RNA polymerase III, have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.75874311
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.75874311
3positive regulation of gamma-delta T cell activation (GO:0046645)6.42428395
4antigen processing and presentation of endogenous antigen (GO:0019883)5.84230530
5regulation of gamma-delta T cell differentiation (GO:0045586)5.77465643
6regulation of gamma-delta T cell activation (GO:0046643)5.13646591
7positive thymic T cell selection (GO:0045059)4.97395671
8negative regulation of erythrocyte differentiation (GO:0045647)4.87679599
9cytoplasmic mRNA processing body assembly (GO:0033962)4.66904743
10negative regulation of cell size (GO:0045792)4.51234068
11positive regulation of histone deacetylation (GO:0031065)4.19843935
12positive regulation of B cell differentiation (GO:0045579)4.09527023
13peptidyl-tyrosine autophosphorylation (GO:0038083)4.04532255
14antigen processing and presentation via MHC class Ib (GO:0002475)4.01660977
15positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.96393405
16viral transcription (GO:0019083)3.86097937
17regulation of chromatin binding (GO:0035561)3.84353595
18megakaryocyte development (GO:0035855)3.83203910
19thymic T cell selection (GO:0045061)3.81936818
20negative regulation of cell killing (GO:0031342)3.77748332
21negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.77748332
22positive T cell selection (GO:0043368)3.77550666
23positive regulation of CREB transcription factor activity (GO:0032793)3.73002405
24regulation of B cell differentiation (GO:0045577)3.60445875
25translational termination (GO:0006415)3.57924035
26regulation of ARF protein signal transduction (GO:0032012)3.57269886
27negative T cell selection (GO:0043383)3.48550712
28negative thymic T cell selection (GO:0045060)3.45436057
29semaphorin-plexin signaling pathway (GO:0071526)3.39903732
30negative regulation of RNA splicing (GO:0033119)3.37755998
31T cell selection (GO:0045058)3.37535549
32negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.35788740
33embryonic hemopoiesis (GO:0035162)3.35290985
34positive regulation of synapse maturation (GO:0090129)3.33639800
35B cell receptor signaling pathway (GO:0050853)3.33324606
36synaptic vesicle docking involved in exocytosis (GO:0016081)3.32059104
37negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.27291141
38insulin-like growth factor receptor signaling pathway (GO:0048009)3.25832128
39intracellular estrogen receptor signaling pathway (GO:0030520)3.25583627
40regulation of fatty acid beta-oxidation (GO:0031998)3.23106946
41regulation of NFAT protein import into nucleus (GO:0051532)3.23099443
42T cell receptor signaling pathway (GO:0050852)3.22064276
43positive regulation of protein deacetylation (GO:0090312)3.21940519
44antigen receptor-mediated signaling pathway (GO:0050851)3.16914343
45cell-cell junction maintenance (GO:0045217)3.14686899
46T cell homeostasis (GO:0043029)3.14330686
47negative regulation of mRNA metabolic process (GO:1903312)3.13754720
48nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.10906277
49regulation of erythrocyte differentiation (GO:0045646)3.09502162
50regulation of interleukin-12 biosynthetic process (GO:0045075)3.09415515
51maturation of SSU-rRNA (GO:0030490)3.07413434
52NIK/NF-kappaB signaling (GO:0038061)3.06982926
53cell migration in hindbrain (GO:0021535)3.06404794
54synaptic vesicle exocytosis (GO:0016079)3.05917143
55ear development (GO:0043583)3.04969064
56translational elongation (GO:0006414)3.04653917
57peptidyl-lysine dimethylation (GO:0018027)3.03719704
58mitochondrion transport along microtubule (GO:0047497)3.03187734
59establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.03187734
60ribosomal small subunit assembly (GO:0000028)3.01174689
61regulation of B cell receptor signaling pathway (GO:0050855)3.00158336
62regulation of short-term neuronal synaptic plasticity (GO:0048172)2.97212206
63negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.96321899
64nucleosome disassembly (GO:0006337)2.96194520
65protein-DNA complex disassembly (GO:0032986)2.96194520
66alternative mRNA splicing, via spliceosome (GO:0000380)2.95952763
67natural killer cell differentiation (GO:0001779)2.95380684
68regulation of histone deacetylation (GO:0031063)2.92119904
69positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.91772953
70definitive hemopoiesis (GO:0060216)2.91686626
71tolerance induction (GO:0002507)2.91377355
72negative regulation of mRNA processing (GO:0050686)2.89582898
73positive regulation of granulocyte differentiation (GO:0030854)2.89020855
74cytoskeletal anchoring at plasma membrane (GO:0007016)2.88967293
75SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.88476261
76JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.88389141
77establishment of mitochondrion localization (GO:0051654)2.86145894
78mannose metabolic process (GO:0006013)2.85827796
79viral life cycle (GO:0019058)2.85449492
80cellular hyperosmotic response (GO:0071474)2.84915783
81activation of JUN kinase activity (GO:0007257)2.82877286
82regulation of synapse maturation (GO:0090128)2.81904913
83protein targeting to ER (GO:0045047)2.79833529
84lymphocyte homeostasis (GO:0002260)2.78900346
853-UTR-mediated mRNA stabilization (GO:0070935)2.78566066
86negative regulation of gene expression, epigenetic (GO:0045814)2.78490064
87apoptotic process involved in morphogenesis (GO:0060561)2.78096238
88cotranslational protein targeting to membrane (GO:0006613)2.76001925
89response to laminar fluid shear stress (GO:0034616)2.75383763
90establishment of protein localization to endoplasmic reticulum (GO:0072599)2.73367544
91adherens junction assembly (GO:0034333)2.71946715
92positive regulation of erythrocyte differentiation (GO:0045648)2.70865451
93positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.69620372
94osteoblast development (GO:0002076)2.69160688
95activation of Rac GTPase activity (GO:0032863)2.68533810
96germ cell migration (GO:0008354)2.67850631
97regulation of stem cell maintenance (GO:2000036)2.66559642
98chromatin silencing (GO:0006342)2.66107041
99response to interleukin-15 (GO:0070672)2.65477030
100negative regulation of stress fiber assembly (GO:0051497)2.64688860
101leukocyte homeostasis (GO:0001776)2.64569116
102histone H3-K4 methylation (GO:0051568)2.64046198
103histone mRNA catabolic process (GO:0071044)2.63498601
104synaptic vesicle endocytosis (GO:0048488)2.62112911
105antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.62107803
106neuronal ion channel clustering (GO:0045161)2.61473911
107protein complex disassembly (GO:0043241)2.60138647
108regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.58710151
109negative regulation of histone methylation (GO:0031061)2.58307313
110glutamate secretion (GO:0014047)2.58140689
111histone H4 deacetylation (GO:0070933)2.58087214
112protein localization to endoplasmic reticulum (GO:0070972)2.57746232
113Peyers patch development (GO:0048541)2.57332739
114mucosal-associated lymphoid tissue development (GO:0048537)2.57332739
115endothelial cell chemotaxis (GO:0035767)2.57107254
116nuclear-transcribed mRNA catabolic process (GO:0000956)2.56892635
117regulation of mRNA catabolic process (GO:0061013)2.55686329
118negative regulation of fatty acid transport (GO:2000192)2.55591837
119cellular protein complex disassembly (GO:0043624)2.54883313
120dendritic spine organization (GO:0097061)2.54748415
121erythrocyte maturation (GO:0043249)2.54246670
122striated muscle atrophy (GO:0014891)2.53944683
123T cell costimulation (GO:0031295)2.53073359
124opioid receptor signaling pathway (GO:0038003)2.52639847
125COPI coating of Golgi vesicle (GO:0048205)2.52146462
126Golgi transport vesicle coating (GO:0048200)2.52146462
127ribosomal small subunit biogenesis (GO:0042274)2.51908621
128mast cell activation (GO:0045576)2.50603238
129cortical actin cytoskeleton organization (GO:0030866)2.49910126
130response to muramyl dipeptide (GO:0032495)2.49857618
131regulation of granulocyte differentiation (GO:0030852)2.49208255
132protein targeting to plasma membrane (GO:0072661)2.48813482
133dopamine receptor signaling pathway (GO:0007212)2.47945096
134lymphocyte costimulation (GO:0031294)2.47790087
135mitochondrion localization (GO:0051646)2.47706682
136mRNA catabolic process (GO:0006402)2.47623039
137activation of protein kinase A activity (GO:0034199)2.47038660
138G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.47033565
139translational initiation (GO:0006413)2.45390763
140regulation of hydrogen peroxide metabolic process (GO:0010310)2.44913666
141focal adhesion assembly (GO:0048041)2.44770011
142cell-substrate adherens junction assembly (GO:0007045)2.44770011
143regulation of cilium assembly (GO:1902017)2.44740470
144activation of MAPKKK activity (GO:0000185)2.44253763
145regulation of ARF GTPase activity (GO:0032312)2.43136143
146histone H3 deacetylation (GO:0070932)2.42597826
147regulation of protein deacetylation (GO:0090311)2.42568322
148regulation of necroptotic process (GO:0060544)2.42414142
149regulation of mammary gland epithelial cell proliferation (GO:0033599)2.42410496
150mast cell degranulation (GO:0043303)2.42080656
151mast cell activation involved in immune response (GO:0002279)2.42080656
152negative regulation of glial cell proliferation (GO:0060253)2.41610480
153cell junction maintenance (GO:0034331)2.37564619
154negative regulation of cAMP-mediated signaling (GO:0043951)2.37318341
155histone H3-K4 trimethylation (GO:0080182)2.36037740
156positive regulation of fatty acid beta-oxidation (GO:0032000)2.33625608
157positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.33027482
158regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.32559573
159snRNA metabolic process (GO:0016073)2.32109531
160myelin maintenance (GO:0043217)2.31617001
161phosphatidylglycerol biosynthetic process (GO:0006655)2.31276967
162skeletal muscle adaptation (GO:0043501)2.31097630
163cell volume homeostasis (GO:0006884)2.30450382
164ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.28748291
165protein insertion into membrane (GO:0051205)2.25143012
166positive regulation of protein dephosphorylation (GO:0035307)2.23790598
167cerebellar granule cell differentiation (GO:0021707)2.22910738
168synaptic vesicle maturation (GO:0016188)2.21334595
169spliceosomal tri-snRNP complex assembly (GO:0000244)2.20928513
170retrograde transport, endosome to Golgi (GO:0042147)2.20025096
171negative regulation of viral release from host cell (GO:1902187)2.19135171
172negative regulation of myotube differentiation (GO:0010832)2.19040066
173positive regulation of receptor recycling (GO:0001921)2.18919184
174positive regulation of protein kinase C signaling (GO:0090037)2.18363579
175positive regulation of histone acetylation (GO:0035066)2.18272998
176positive regulation of Rac GTPase activity (GO:0032855)2.17827058
177regulation of defense response to virus by virus (GO:0050690)2.17816120
178layer formation in cerebral cortex (GO:0021819)2.17543083
179negative regulation of granulocyte differentiation (GO:0030853)2.17199918
180modulation by virus of host process (GO:0019054)2.15872779
181histone lysine methylation (GO:0034968)2.15281467
182epithelial cell differentiation involved in prostate gland development (GO:0060742)2.14555160
183retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.13710775

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_22102868_ChIP-Seq_BL_Human4.01331195
2SCL_19346495_ChIP-Seq_HPC-7_Human3.49877009
3E2F7_22180533_ChIP-Seq_HELA_Human3.25262877
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.15166448
5EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.15088114
6VDR_21846776_ChIP-Seq_THP-1_Human3.10198532
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.03343812
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.89473182
9* TCF7_22412390_ChIP-Seq_EML_Mouse2.72733908
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.72170891
11THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.72017810
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.64174704
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.61675922
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.51589728
15MAF_26560356_Chip-Seq_TH1_Human2.43660641
16UTX_26944678_Chip-Seq_JUKART_Human2.42442629
17KDM2B_26808549_Chip-Seq_DND41_Human2.38907506
18KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.34428176
19TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.32155171
20DROSHA_22980978_ChIP-Seq_HELA_Human2.27904692
21KDM2B_26808549_Chip-Seq_K562_Human2.24686918
22ESR2_21235772_ChIP-Seq_MCF-7_Human2.24355955
23FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.22917503
24KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.21555856
25FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.17034834
26EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.17025602
27KDM2B_26808549_Chip-Seq_SUP-B15_Human2.08155575
28E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.07030908
29RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.06683659
30MYB_26560356_Chip-Seq_TH2_Human2.06131459
31CIITA_25753668_ChIP-Seq_RAJI_Human2.05306558
32* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human2.02631989
33VDR_24763502_ChIP-Seq_THP-1_Human2.02087310
34SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.00432258
35SMC4_20622854_ChIP-Seq_HELA_Human1.98248534
36TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.97455086
37MYB_26560356_Chip-Seq_TH1_Human1.97176911
38TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.94986647
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.93761698
40CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.93404364
41TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92698323
42ELK3_25401928_ChIP-Seq_HUVEC_Human1.90100574
43STAT6_21828071_ChIP-Seq_BEAS2B_Human1.88382914
44ERG_21242973_ChIP-ChIP_JURKAT_Human1.87360662
45RUNX1_22412390_ChIP-Seq_EML_Mouse1.87137355
46ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.85687514
47RUNX_20019798_ChIP-Seq_JUKART_Human1.84923245
48MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.83943688
49DNAJC2_21179169_ChIP-ChIP_NT2_Human1.83290175
50MAF_26560356_Chip-Seq_TH2_Human1.82641828
51GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.80328011
52TET1_21451524_ChIP-Seq_MESCs_Mouse1.78694844
53GATA1_22383799_ChIP-Seq_G1ME_Mouse1.76239634
54RARG_19884340_ChIP-ChIP_MEFs_Mouse1.73076229
55CREB1_26743006_Chip-Seq_LNCaP_Human1.72398638
56ZFP281_18757296_ChIP-ChIP_E14_Mouse1.66774602
57RUNX1_27514584_Chip-Seq_MCF-7_Human1.66769518
58BRD4_27068464_Chip-Seq_AML-cells_Mouse1.66635599
59CTCF_27219007_Chip-Seq_Bcells_Human1.62829055
60MYB_21317192_ChIP-Seq_ERMYB_Mouse1.60790194
61TP63_17297297_ChIP-ChIP_HaCaT_Human1.60209300
62SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.60008235
63VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.59875378
64LXR_22292898_ChIP-Seq_THP-1_Human1.59830626
65* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.55986221
66* GATA1_19941827_ChIP-Seq_MEL_Mouse1.55707775
67SPI1_23547873_ChIP-Seq_NB4_Human1.53916957
68SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.49603442
69SPI1_23127762_ChIP-Seq_K562_Human1.49602828
70KDM2B_26808549_Chip-Seq_JURKAT_Human1.49453552
71IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.48373600
72CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.47022295
73RARB_27405468_Chip-Seq_BRAIN_Mouse1.46041510
74BCL6_27268052_Chip-Seq_Bcells_Human1.43580288
75UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.43558944
76MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.41592192
77SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.41014014
78STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.40924514
79GATA2_22383799_ChIP-Seq_G1ME_Mouse1.39460657
80ZFP281_27345836_Chip-Seq_ESCs_Mouse1.38581247
81STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.38114675
82IRF8_27001747_Chip-Seq_BMDM_Mouse1.37259517
83STAT4_19710469_ChIP-ChIP_TH1__Mouse1.37048507
84CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.34487336
85FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.33770821
86ESR1_21235772_ChIP-Seq_MCF-7_Human1.32947100
87FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.32494540
88SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.31509283
89SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.30445374
90NCOR1_26117541_ChIP-Seq_K562_Human1.29948639
91TP53_22127205_ChIP-Seq_IMR90_Human1.29589946
92ELF1_20517297_ChIP-Seq_JURKAT_Human1.29552739
93MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.28173620
94NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.26895491
95GATA1_19941826_ChIP-Seq_K562_Human1.26365826
96TP63_22573176_ChIP-Seq_HFKS_Human1.26099221
97GATA3_27048872_Chip-Seq_THYMUS_Human1.24695578
98WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.23554711
99EZH2_27294783_Chip-Seq_ESCs_Mouse1.23435255
100KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.22144701
101* TET1_21490601_ChIP-Seq_MESCs_Mouse1.20840571
102OCT4_19829295_ChIP-Seq_ESCs_Human1.19098742
103SUZ12_27294783_Chip-Seq_ESCs_Mouse1.18985827
104TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.18980051
105KDM5A_27292631_Chip-Seq_BREAST_Human1.17113796
106PHF8_20622854_ChIP-Seq_HELA_Human1.15854948
107DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.13935528
108LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.13908747
109ERG_20887958_ChIP-Seq_HPC-7_Mouse1.13874822
110DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.13094746
111E2F1_20622854_ChIP-Seq_HELA_Human1.12984282
112IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.12774568
113GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.12688725
114SRY_22984422_ChIP-ChIP_TESTIS_Rat1.12043725
115CTCF_21964334_ChIP-Seq_BJAB-B_Human1.11173785
116RACK7_27058665_Chip-Seq_MCF-7_Human1.10856876
117JARID2_20075857_ChIP-Seq_MESCs_Mouse1.10496067
118GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.10175997
119P68_20966046_ChIP-Seq_HELA_Human1.09772005
120RARB_24833708_ChIP-Seq_LIVER_Mouse1.09655051
121ESR1_20079471_ChIP-ChIP_T-47D_Human1.08686326
122LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.08568490
123CTCF_27219007_Chip-Seq_ERYTHROID_Human1.08324025
124ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.08093340
125CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.08004236
126SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.07480930
127E2F4_17652178_ChIP-ChIP_JURKAT_Human1.07444558
128CTCF_26484167_Chip-Seq_Bcells_Mouse1.07118617
129RNF2_27304074_Chip-Seq_ESCs_Mouse1.06716471
130PKCTHETA_26484144_Chip-Seq_BREAST_Human1.05813307
131IKZF1_21737484_ChIP-ChIP_HCT116_Human1.05632556
132TP53_23651856_ChIP-Seq_MEFs_Mouse1.05408280
133XRN2_22483619_ChIP-Seq_HELA_Human1.04191144
134CTCF_21964334_Chip-Seq_Bcells_Human1.03898599
135* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.03850322
136* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01114147
137SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.00618687
138* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.00391697
139ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00217119
140ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.98964260
141SA1_27219007_Chip-Seq_Bcells_Human0.98536859
142JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.97829648
143PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97729282
144KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.97244869
145FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.97204836
146E2F1_21310950_ChIP-Seq_MCF-7_Human0.97128008
147RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96107894
148SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.95658605
149PU.1_20513432_ChIP-Seq_Bcells_Mouse0.93294155
150CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92696823
151TFEB_21752829_ChIP-Seq_HELA_Human0.92567264
152IRF8_21731497_ChIP-ChIP_J774_Mouse0.91926096
153PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91185326
154P300_27058665_Chip-Seq_ZR-75-30cells_Human0.90191691
155* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.89091577
156SA1_27219007_Chip-Seq_ERYTHROID_Human0.88330649
157ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.87903064
158ATF3_27146783_Chip-Seq_COLON_Human0.87870392
159ZNF263_19887448_ChIP-Seq_K562_Human0.87428408
160BCOR_27268052_Chip-Seq_Bcells_Human0.86876637
161* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.86334172
162NFIB_24661679_ChIP-Seq_LUNG_Mouse0.86057840

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.51629522
2MP0003300_gastrointestinal_ulcer3.27022762
3MP0003763_abnormal_thymus_physiology3.17232730
4MP0009278_abnormal_bone_marrow3.16310978
5MP0002396_abnormal_hematopoietic_system3.07628763
6MP0004858_abnormal_nervous_system2.99160325
7MP0001545_abnormal_hematopoietic_system2.75212705
8MP0005397_hematopoietic_system_phenotyp2.75212705
9MP0002249_abnormal_larynx_morphology2.42313091
10MP0000685_abnormal_immune_system2.42291935
11MP0005423_abnormal_somatic_nervous2.41105682
12MP0004808_abnormal_hematopoietic_stem2.38594286
13MP0003329_amyloid_beta_deposits2.30220970
14MP0001835_abnormal_antigen_presentation2.29630345
15MP0002398_abnormal_bone_marrow2.28696703
16MP0002166_altered_tumor_susceptibility2.26435672
17MP0005451_abnormal_body_composition2.23033979
18MP0001800_abnormal_humoral_immune2.19828709
19MP0001873_stomach_inflammation2.09398676
20MP0003303_peritoneal_inflammation2.08055316
21MP0001348_abnormal_lacrimal_gland2.07932149
22MP0000703_abnormal_thymus_morphology1.97226526
23MP0005464_abnormal_platelet_physiology1.91850090
24MP0002822_catalepsy1.91346548
25MP0005671_abnormal_response_to1.89765033
26MP0002452_abnormal_antigen_presenting1.87092109
27MP0002420_abnormal_adaptive_immunity1.84311800
28MP0000716_abnormal_immune_system1.80311680
29MP0001819_abnormal_immune_cell1.79768752
30MP0000689_abnormal_spleen_morphology1.79659178
31MP0002723_abnormal_immune_serum1.79387239
32MP0005174_abnormal_tail_pigmentation1.78391508
33MP0008961_abnormal_basal_metabolism1.77444534
34MP0002722_abnormal_immune_system1.76330116
35MP0001790_abnormal_immune_system1.76070878
36MP0005387_immune_system_phenotype1.76070878
37MP0004947_skin_inflammation1.75148100
38MP0005670_abnormal_white_adipose1.71579719
39MP0003183_abnormal_peptide_metabolism1.69175603
40MP0000465_gastrointestinal_hemorrhage1.69078127
41MP0003635_abnormal_synaptic_transmissio1.68792503
42MP0008260_abnormal_autophagy1.68753218
43MP0000569_abnormal_digit_pigmentation1.67846977
44MP0010234_abnormal_vibrissa_follicle1.65798342
45MP0003191_abnormal_cellular_cholesterol1.65107372
46MP0005409_darkened_coat_color1.64848404
47MP0002429_abnormal_blood_cell1.63761817
48MP0002735_abnormal_chemical_nociception1.63147676
49MP0003866_abnormal_defecation1.62552865
50MP0008007_abnormal_cellular_replicative1.61167267
51MP0005076_abnormal_cell_differentiation1.58174348
52MP0004381_abnormal_hair_follicle1.57532179
53MP0001502_abnormal_circadian_rhythm1.55041888
54MP0005000_abnormal_immune_tolerance1.54898333
55MP0003879_abnormal_hair_cell1.53632400
56MP0002063_abnormal_learning/memory/cond1.52635760
57MP0004233_abnormal_muscle_weight1.52188424
58MP0000678_abnormal_parathyroid_gland1.50736616
59MP0005220_abnormal_exocrine_pancreas1.50417925
60MP0005025_abnormal_response_to1.47273930
61MP0009333_abnormal_splenocyte_physiolog1.47240607
62MP0003656_abnormal_erythrocyte_physiolo1.46464300
63MP0003077_abnormal_cell_cycle1.44264466
64MP0010352_gastrointestinal_tract_polyps1.43442851
65MP0002405_respiratory_system_inflammati1.42825089
66MP0009840_abnormal_foam_cell1.42293507
67MP0002006_tumorigenesis1.38201936
68MP0002933_joint_inflammation1.38163194
69MP0003283_abnormal_digestive_organ1.34707179
70MP0005645_abnormal_hypothalamus_physiol1.32499888
71MP0004147_increased_porphyrin_level1.32120778
72MP0010155_abnormal_intestine_physiology1.31468206
73MP0001849_ear_inflammation1.30642506
74MP0000490_abnormal_crypts_of1.29400703
75MP0000681_abnormal_thyroid_gland1.26822407
76MP0003111_abnormal_nucleus_morphology1.25740835
77MP0002064_seizures1.24903544
78MP0000751_myopathy1.23515906
79MP0000371_diluted_coat_color1.21797688
80MP0000733_abnormal_muscle_development1.19262597
81MP0002877_abnormal_melanocyte_morpholog1.19245180
82MP0003436_decreased_susceptibility_to1.18174257
83MP0002653_abnormal_ependyma_morphology1.17255815
84MP0002419_abnormal_innate_immunity1.17192062
85MP0003705_abnormal_hypodermis_morpholog1.16928560
86MP0000566_synostosis1.14858802
87MP0005075_abnormal_melanosome_morpholog1.14570312
88MP0004510_myositis1.13802658
89MP0000747_muscle_weakness1.13163546
90MP0006054_spinal_hemorrhage1.12879999
91MP0001845_abnormal_inflammatory_respons1.08527583
92MP0002572_abnormal_emotion/affect_behav1.08037547
93MP0002970_abnormal_white_adipose1.07603761
94MP0002019_abnormal_tumor_incidence1.07247054
95MP0003634_abnormal_glial_cell1.04090444
96MP0001486_abnormal_startle_reflex1.03607615
97MP0001501_abnormal_sleep_pattern1.01843714
98MP0008569_lethality_at_weaning1.01115727
99MP0004185_abnormal_adipocyte_glucose1.00874030
100MP0003252_abnormal_bile_duct1.00471783
101MP0002928_abnormal_bile_duct0.99835477
102MP0000383_abnormal_hair_follicle0.99548327
103MP0001853_heart_inflammation0.99406102
104MP0005083_abnormal_biliary_tract0.98436925
105MP0003172_abnormal_lysosome_physiology0.98121847
106MP0002734_abnormal_mechanical_nocicepti0.97167245
107MP0005377_hearing/vestibular/ear_phenot0.97007431
108MP0003878_abnormal_ear_physiology0.97007431
109MP0003566_abnormal_cell_adhesion0.95337508
110MP0001958_emphysema0.94631581
111MP0001970_abnormal_pain_threshold0.94287179
112MP0003693_abnormal_embryo_hatching0.92480680
113MP0002098_abnormal_vibrissa_morphology0.92405287
114MP0001968_abnormal_touch/_nociception0.90769198
115MP0000604_amyloidosis0.90394617
116MP0000759_abnormal_skeletal_muscle0.89860550
117MP0002733_abnormal_thermal_nociception0.89459503
118MP0010094_abnormal_chromosome_stability0.89307150
119MP0005023_abnormal_wound_healing0.89235909
120MP0009745_abnormal_behavioral_response0.88604364
121MP0000350_abnormal_cell_proliferation0.88167692
122MP0000313_abnormal_cell_death0.87964908
123MP0000537_abnormal_urethra_morphology0.87400076
124MP0005167_abnormal_blood-brain_barrier0.85743846
125MP0004270_analgesia0.85729648
126MP0000858_altered_metastatic_potential0.84680156
127MP0001730_embryonic_growth_arrest0.84592272
128MP0003091_abnormal_cell_migration0.84389020
129MP0009785_altered_susceptibility_to0.84141865
130MP0006138_congestive_heart_failure0.83835717
131MP0002089_abnormal_postnatal_growth/wei0.82812544
132MP0010307_abnormal_tumor_latency0.82433546
133MP0003453_abnormal_keratinocyte_physiol0.81466713
134MP0003943_abnormal_hepatobiliary_system0.80803863
135MP0002009_preneoplasia0.80765729
136MP0005375_adipose_tissue_phenotype0.80528877
137MP0005058_abnormal_lysosome_morphology0.78493164
138MP0010630_abnormal_cardiac_muscle0.77340010
139MP0005666_abnormal_adipose_tissue0.77093249
140MP0001986_abnormal_taste_sensitivity0.76862458
141MP0000609_abnormal_liver_physiology0.76258530
142MP0008874_decreased_physiological_sensi0.76172557
143MP0000750_abnormal_muscle_regeneration0.74550691
144MP0000467_abnormal_esophagus_morphology0.74430597
145MP0008469_abnormal_protein_level0.74105969
146MP0000462_abnormal_digestive_system0.73689870
147MP0005310_abnormal_salivary_gland0.72755799
148MP0003045_fibrosis0.72251610
149MP0001664_abnormal_digestion0.71761304
150MP0000955_abnormal_spinal_cord0.70933955
151MP0000470_abnormal_stomach_morphology0.70933475
152MP0000598_abnormal_liver_morphology0.70913873
153MP0003948_abnormal_gas_homeostasis0.69751245
154MP0000015_abnormal_ear_pigmentation0.69474280
155MP0000013_abnormal_adipose_tissue0.68537676
156MP0003646_muscle_fatigue0.68429969
157MP0000534_abnormal_ureter_morphology0.68261875
158MP0002932_abnormal_joint_morphology0.68209318
159MP0000477_abnormal_intestine_morphology0.67168363
160MP0000003_abnormal_adipose_tissue0.66663625
161MP0003279_aneurysm0.66245532
162MP0008877_abnormal_DNA_methylation0.65518649
163MP0009672_abnormal_birth_weight0.65491199
164MP0002882_abnormal_neuron_morphology0.65232839
165MP0002080_prenatal_lethality0.64996830
166MP0001944_abnormal_pancreas_morphology0.64744807
167MP0003448_altered_tumor_morphology0.64474159
168MP0004130_abnormal_muscle_cell0.64402099
169MP0008770_decreased_survivor_rate0.62870735
170MP0002060_abnormal_skin_morphology0.62213444
171MP0002092_abnormal_eye_morphology0.61923626
172MP0002557_abnormal_social/conspecific_i0.61031440
173MP0002332_abnormal_exercise_endurance0.60818541

Predicted human phenotypes

RankGene SetZ-score
1Obstructive sleep apnea (HP:0002870)5.40989926
2Hyperacusis (HP:0010780)4.27169940
3Stridor (HP:0010307)4.17175381
4Chronic otitis media (HP:0000389)3.92949794
5Recurrent bronchitis (HP:0002837)3.88242466
6Broad face (HP:0000283)3.73980862
7Abnormality of the fingertips (HP:0001211)3.68489464
8Nasal polyposis (HP:0100582)3.64881371
9IgM deficiency (HP:0002850)3.57531541
10Recurrent viral infections (HP:0004429)3.55239913
11J-shaped sella turcica (HP:0002680)3.47150634
12Colitis (HP:0002583)3.46478502
13T lymphocytopenia (HP:0005403)3.35742379
14Gastrointestinal inflammation (HP:0004386)3.35098678
15Inflammation of the large intestine (HP:0002037)3.32958443
16Abnormality of the nasal mucosa (HP:0000433)3.31748857
17Reticulocytopenia (HP:0001896)3.30785753
18Upper limb amyotrophy (HP:0009129)3.22948969
19Distal upper limb amyotrophy (HP:0007149)3.22948969
20Spontaneous hematomas (HP:0007420)3.12331877
21Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.04711449
22Panhypogammaglobulinemia (HP:0003139)3.00049609
23Prolonged bleeding time (HP:0003010)2.99197046
24Increased IgE level (HP:0003212)2.98652948
25Recurrent fungal infections (HP:0002841)2.97473500
26Abnormality of the heme biosynthetic pathway (HP:0010472)2.95057287
27Agammaglobulinemia (HP:0004432)2.92309051
28Abnormality of cells of the erythroid lineage (HP:0012130)2.91960104
29Abnormality of T cell number (HP:0011839)2.91603653
30Bronchitis (HP:0012387)2.88215644
31Abnormal number of erythroid precursors (HP:0012131)2.87769329
32Insomnia (HP:0100785)2.87696056
33Abnormal delayed hypersensitivity skin test (HP:0002963)2.87302429
34Elfin facies (HP:0004428)2.86939569
35Pustule (HP:0200039)2.86600691
36Cellulitis (HP:0100658)2.85228681
37Ankle clonus (HP:0011448)2.84688834
38B lymphocytopenia (HP:0010976)2.72897198
39Abnormality of B cell number (HP:0010975)2.72897198
40Verrucae (HP:0200043)2.70060872
41Papilloma (HP:0012740)2.70060872
42Abnormality of T cells (HP:0002843)2.66069142
43Elevated erythrocyte sedimentation rate (HP:0003565)2.63737419
44Hand muscle atrophy (HP:0009130)2.63589441
45Lymphangioma (HP:0100764)2.60182756
46Abnormality of the thoracic spine (HP:0100711)2.58124939
47Thin bony cortex (HP:0002753)2.54709268
48Pointed chin (HP:0000307)2.53166991
49Overriding aorta (HP:0002623)2.51997874
50Annular pancreas (HP:0001734)2.50523962
51Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.50423225
52Dysmetric saccades (HP:0000641)2.47512070
53Rectal prolapse (HP:0002035)2.46876224
54Ulnar bowing (HP:0003031)2.46427926
55Increased neuronal autofluorescent lipopigment (HP:0002074)2.43495931
56Fatigue (HP:0012378)2.39993409
57Sparse lateral eyebrow (HP:0005338)2.39170338
58Germ cell neoplasia (HP:0100728)2.38791496
59Distal lower limb muscle weakness (HP:0009053)2.38646433
60Thrombocytosis (HP:0001894)2.38561381
61Eczematoid dermatitis (HP:0000976)2.37258542
62Pallor (HP:0000980)2.36858320
63Abnormality of DNA repair (HP:0003254)2.36709181
64Diaphragmatic weakness (HP:0009113)2.35602312
65Impaired platelet aggregation (HP:0003540)2.35177866
66Abnormal platelet function (HP:0011869)2.35177866
67Increased cerebral lipofuscin (HP:0011813)2.32090357
68Petechiae (HP:0000967)2.29818316
69Dysostosis multiplex (HP:0000943)2.28278232
70Renovascular hypertension (HP:0100817)2.28094574
71Acute lymphatic leukemia (HP:0006721)2.27989974
72Cerebral aneurysm (HP:0004944)2.26540997
73Deformed sella turcica (HP:0002681)2.26047383
74Broad distal phalanx of finger (HP:0009836)2.24957323
75Increased density of long bones (HP:0006392)2.24549466
76Hematochezia (HP:0002573)2.22968807
77Achilles tendon contracture (HP:0001771)2.22830111
78Long palpebral fissure (HP:0000637)2.22683849
79Bronchomalacia (HP:0002780)2.21520678
80Distal lower limb amyotrophy (HP:0008944)2.21124923
81Osteomyelitis (HP:0002754)2.21118059
82Bicuspid aortic valve (HP:0001647)2.20533644
83Flat acetabular roof (HP:0003180)2.18539360
84Recurrent cutaneous fungal infections (HP:0011370)2.17482246
85Chronic mucocutaneous candidiasis (HP:0002728)2.17482246
86Emphysema (HP:0002097)2.16829891
87Abnormality of polysaccharide metabolism (HP:0011012)2.16285720
88Abnormality of glycosaminoglycan metabolism (HP:0004371)2.16285720
89Abnormality of mucopolysaccharide metabolism (HP:0011020)2.16285720
90Recurrent sinusitis (HP:0011108)2.15798990
91Lymphopenia (HP:0001888)2.15425682
92Abnormality of T cell physiology (HP:0011840)2.15021848
93Supranuclear gaze palsy (HP:0000605)2.15008433
94Duplicated collecting system (HP:0000081)2.14388890
95Atelectasis (HP:0100750)2.14270079
96Abnormality of the aortic arch (HP:0012303)2.13625370
97Mediastinal lymphadenopathy (HP:0100721)2.13537188
98Epistaxis (HP:0000421)2.13351684
99Lower limb asymmetry (HP:0100559)2.13224938
100Prominent nose (HP:0000448)2.12866087
101Long eyelashes (HP:0000527)2.12704160
102Absent rod-and cone-mediated responses on ERG (HP:0007688)2.11422208
103Precocious puberty (HP:0000826)2.10729624
104Clumsiness (HP:0002312)2.10690214
105Urinary glycosaminoglycan excretion (HP:0003541)2.08469381
106Mucopolysacchariduria (HP:0008155)2.08469381
107Myopathic facies (HP:0002058)2.08017450
108Gastrointestinal stroma tumor (HP:0100723)2.07885991
109Abnormality of cells of the lymphoid lineage (HP:0012140)2.06856423
110Macroorchidism (HP:0000053)2.06282323
111Chronic diarrhea (HP:0002028)2.04509450
112Aortic aneurysm (HP:0004942)2.01886825
113Abnormality of the radial head (HP:0003995)1.98740111
114Hypercortisolism (HP:0001578)1.98254686
115Easy fatigability (HP:0003388)1.96481777
116Visual hallucinations (HP:0002367)1.95110188
117Difficulty climbing stairs (HP:0003551)1.94957720
118Bowel incontinence (HP:0002607)1.94771386
119Neuronal loss in central nervous system (HP:0002529)1.93922240
120Increased nuchal translucency (HP:0010880)1.93090063
121Dislocated radial head (HP:0003083)1.89882944
122Fetal akinesia sequence (HP:0001989)1.89613707
123Interstitial pulmonary disease (HP:0006530)1.89575689
124Meningitis (HP:0001287)1.89293431
125Recurrent otitis media (HP:0000403)1.89197055
126Heterotopia (HP:0002282)1.88866910
127Sleep apnea (HP:0010535)1.88805335
128Genetic anticipation (HP:0003743)1.88802190
129Chronic sinusitis (HP:0011109)1.88679440
130Patellar dislocation (HP:0002999)1.88502885
131Cervical subluxation (HP:0003308)1.87978353
132Abnormality of reticulocytes (HP:0004312)1.87922665
133Flat cornea (HP:0007720)1.87889596
134High pitched voice (HP:0001620)1.86338994
135Turricephaly (HP:0000262)1.86045167
136Thoracic kyphosis (HP:0002942)1.85676658
137Shallow orbits (HP:0000586)1.84744331
138Abnormality of the renal collecting system (HP:0004742)1.84526498
139Thyroiditis (HP:0100646)1.81976423
140Abnormality of the Achilles tendon (HP:0005109)1.80949747
141Neoplasm of the heart (HP:0100544)1.80926770
142Difficulty running (HP:0009046)1.80354810
143Mitral regurgitation (HP:0001653)1.79837832
144Obsessive-compulsive behavior (HP:0000722)1.77134338
145Disproportionate tall stature (HP:0001519)1.77061282
146Renal duplication (HP:0000075)1.76945701
147Bladder diverticulum (HP:0000015)1.76192045
148Visceral angiomatosis (HP:0100761)1.75804651
149Broad palm (HP:0001169)1.74702250
150Abnormality of the sella turcica (HP:0002679)1.74526695
151Cerebral inclusion bodies (HP:0100314)1.74162310
152Truncal ataxia (HP:0002078)1.73648701
153Centrally nucleated skeletal muscle fibers (HP:0003687)1.73292743
154Bell-shaped thorax (HP:0001591)1.73209331
155Increased connective tissue (HP:0009025)1.73157055
156Onion bulb formation (HP:0003383)1.73036837
157Neurofibrillary tangles (HP:0002185)1.72835416
158Abnormal large intestine physiology (HP:0012700)1.72686911
159Hyperthyroidism (HP:0000836)1.72473641
160Abnormality of the periventricular white matter (HP:0002518)1.72129749
161Bowel diverticulosis (HP:0005222)1.72085025
162IgA deficiency (HP:0002720)1.71568714
163Spastic gait (HP:0002064)1.71519889
164Spondylolisthesis (HP:0003302)1.70888605
165Limited elbow extension (HP:0001377)1.69766437
166Leukocytosis (HP:0001974)1.69220235
167Basal cell carcinoma (HP:0002671)1.69166181
168Megalocornea (HP:0000485)1.68954172
169Poikilocytosis (HP:0004447)1.68950400
170Mildly elevated creatine phosphokinase (HP:0008180)1.68600564
171Spinal canal stenosis (HP:0003416)1.68544331
172Bronchiectasis (HP:0002110)1.67974918
173Recurrent abscess formation (HP:0002722)1.65949673
174Hypoplasia of the thymus (HP:0000778)1.65789048
175Stereotypic behavior (HP:0000733)1.65608467
176Long toe (HP:0010511)1.63781459
177Lip pit (HP:0100267)1.63161261
178Tented upper lip vermilion (HP:0010804)1.62915028
179Lower limb amyotrophy (HP:0007210)1.61926741
180Spina bifida occulta (HP:0003298)1.61722251
181Autoimmune thrombocytopenia (HP:0001973)1.60786941
182Abnormal rod and cone electroretinograms (HP:0008323)1.60473934
183Truncus arteriosus (HP:0001660)1.59429337
184Vertebral arch anomaly (HP:0008438)1.59148640
185Abnormality of the columella (HP:0009929)1.58964009

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K3.84984741
2TRIB33.71713468
3MAP4K13.56984416
4MAP3K103.06316499
5SMG12.64636374
6PKN22.41810080
7PRPF4B2.24350190
8NEK22.23764259
9ZAP702.12669691
10BRD42.10831865
11BLK2.04088347
12SIK22.01816289
13TNK21.98290976
14KIT1.96809437
15FLT31.96005295
16ERN11.87480671
17PRKD31.84396790
18CAMKK11.80509762
19STK101.74145391
20TAOK31.68475389
21MARK31.62767534
22LRRK21.61797058
23TYK21.61362134
24LMTK21.58450601
25BRSK21.58238193
26JAK31.56525480
27CSF1R1.55085374
28FGFR41.54721169
29MAP2K21.47140665
30PTK61.44069374
31EPHA21.39633191
32SCYL21.37556897
33SIK11.36709655
34MAP3K111.31597599
35BTK1.28559886
36PRKD21.28289347
37RPS6KA41.27910627
38MAP2K31.26816411
39RPS6KA21.25845632
40TGFBR21.24032993
41TBK11.21390409
42TXK1.21201654
43ITK1.12701091
44MAP3K71.11585154
45IKBKE1.10664480
46RPS6KC11.05644334
47RPS6KL11.05644334
48JAK11.04044250
49HIPK21.03254422
50MARK21.02710145
51TTN1.01831646
52CAMK1D1.01500165
53PRKCH1.00907448
54SYK0.98755259
55EPHB10.98496134
56CDC42BPA0.96266595
57RPS6KA60.95886299
58IRAK30.95064705
59RPS6KB20.94293935
60GRK60.93127728
61DYRK1B0.92232121
62LCK0.91503419
63CAMK1G0.91454341
64BRSK10.90734020
65DYRK30.90395403
66HCK0.89649609
67MARK10.89297759
68MAP2K60.88789297
69ACVR1B0.88387395
70FES0.86954114
71PDPK10.86133659
72PIM20.85970198
73PASK0.85705654
74CDK60.81554385
75MAPK150.81416758
76TAOK10.81088499
77PAK60.81036443
78CDK40.78838309
79NTRK20.78220487
80MAP3K60.77965194
81JAK20.77800364
82MAPKAPK30.76407836
83RIPK10.75673025
84MELK0.75417103
85CDK120.75282844
86MAP3K130.74658288
87NME20.73337259
88CSK0.73264353
89MTOR0.73160338
90NLK0.71893768
91TGFBR10.70585579
92DAPK20.69498493
93CDC70.66828471
94MAP3K80.66801824
95STK380.65071945
96PRKAA10.62409451
97CAMK40.61400890
98FGFR20.61367364
99PDK10.60890030
100FGFR30.60844707
101PDGFRB0.60449545
102MAP2K40.59548595
103ICK0.59237819
104MAP3K10.58606823
105CDK90.57310319
106PIM10.56813798
107CAMK10.56107125
108PDGFRA0.55966928
109TEC0.55798909
110CLK10.54979619
111MAPK110.54851979
112MAP3K30.54281594
113PKN10.53261924
114MAPK80.51126767
115SIK30.51035956
116TESK10.50405405
117TYRO30.50238419
118ATR0.50195093
119PAK20.50150959
120RET0.49610614
121KDR0.49413098
122SGK30.49144700
123MAPK70.48446269
124NTRK30.48395402
125PHKG10.48188848
126PHKG20.48188848
127ALK0.47949248
128MUSK0.47835294
129STK40.47600285
130PRKD10.45122108
131STK110.44482795
132DMPK0.44304623
133MAPK100.44278590
134MAPK40.41423335
135LYN0.41065177
136MAP3K140.39994223
137PRKCI0.39724662
138EPHA40.39638078
139IKBKB0.39527291
140BMX0.39201896
141CHUK0.38953877
142MAPK120.38374116
143TESK20.38074284
144PRKAA20.37346012
145MAPKAPK20.37080224
146ILK0.37052206
147PAK40.36228940
148KSR20.35115432
149RPS6KA10.34342587
150RIPK40.32531486
151PRKCZ0.31964959
152UHMK10.31278921

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.50301695
2B cell receptor signaling pathway_Homo sapiens_hsa046622.69555791
3Antigen processing and presentation_Homo sapiens_hsa046122.22749320
4Chronic myeloid leukemia_Homo sapiens_hsa052202.14177159
5T cell receptor signaling pathway_Homo sapiens_hsa046602.13312281
6Acute myeloid leukemia_Homo sapiens_hsa052212.06703464
7Osteoclast differentiation_Homo sapiens_hsa043801.87223566
8Hematopoietic cell lineage_Homo sapiens_hsa046401.80823172
9Notch signaling pathway_Homo sapiens_hsa043301.71877102
10Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.68189206
11Measles_Homo sapiens_hsa051621.67874045
12Leishmaniasis_Homo sapiens_hsa051401.61278205
13Ribosome_Homo sapiens_hsa030101.59716589
14Lysine degradation_Homo sapiens_hsa003101.59135087
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.55169428
16Spliceosome_Homo sapiens_hsa030401.52653584
17Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.50931483
18Platelet activation_Homo sapiens_hsa046111.47470306
19Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.47256002
20ErbB signaling pathway_Homo sapiens_hsa040121.41413723
21Herpes simplex infection_Homo sapiens_hsa051681.39987843
22Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.35605897
23Non-small cell lung cancer_Homo sapiens_hsa052231.35066447
24Toxoplasmosis_Homo sapiens_hsa051451.33545896
25Small cell lung cancer_Homo sapiens_hsa052221.32264765
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.29349941
27Leukocyte transendothelial migration_Homo sapiens_hsa046701.29329851
28Choline metabolism in cancer_Homo sapiens_hsa052311.29014275
29GnRH signaling pathway_Homo sapiens_hsa049121.28226452
30Nitrogen metabolism_Homo sapiens_hsa009101.25956595
31Inositol phosphate metabolism_Homo sapiens_hsa005621.25728313
32Apoptosis_Homo sapiens_hsa042101.25674762
33Synaptic vesicle cycle_Homo sapiens_hsa047211.25230364
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.22456337
35Jak-STAT signaling pathway_Homo sapiens_hsa046301.21956476
36Pancreatic cancer_Homo sapiens_hsa052121.21717779
37AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.21116036
38Estrogen signaling pathway_Homo sapiens_hsa049151.20318013
39Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.20004761
40Hepatitis B_Homo sapiens_hsa051611.17634527
41Transcriptional misregulation in cancer_Homo sapiens_hsa052021.16514665
42Intestinal immune network for IgA production_Homo sapiens_hsa046721.16049339
43ABC transporters_Homo sapiens_hsa020101.15972023
44DNA replication_Homo sapiens_hsa030301.13944145
45Cyanoamino acid metabolism_Homo sapiens_hsa004601.13650452
46mTOR signaling pathway_Homo sapiens_hsa041501.12092290
47Neurotrophin signaling pathway_Homo sapiens_hsa047221.11392700
48Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.09413001
49Circadian entrainment_Homo sapiens_hsa047131.09066050
50NOD-like receptor signaling pathway_Homo sapiens_hsa046211.08392813
51Insulin resistance_Homo sapiens_hsa049311.08093990
52Other glycan degradation_Homo sapiens_hsa005111.07541070
53HTLV-I infection_Homo sapiens_hsa051661.07421178
54Oxytocin signaling pathway_Homo sapiens_hsa049211.07382444
55Long-term potentiation_Homo sapiens_hsa047201.06768240
56Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.06163904
57Cholinergic synapse_Homo sapiens_hsa047251.05620595
58Shigellosis_Homo sapiens_hsa051311.04645963
59Glycosaminoglycan degradation_Homo sapiens_hsa005311.03243025
60Influenza A_Homo sapiens_hsa051641.02946030
61Viral carcinogenesis_Homo sapiens_hsa052030.99561854
62VEGF signaling pathway_Homo sapiens_hsa043700.98530375
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.97785242
64Caffeine metabolism_Homo sapiens_hsa002320.97007915
65Selenocompound metabolism_Homo sapiens_hsa004500.96603583
66Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.95690198
67Renal cell carcinoma_Homo sapiens_hsa052110.94636441
68MicroRNAs in cancer_Homo sapiens_hsa052060.94374131
69Colorectal cancer_Homo sapiens_hsa052100.94058750
70TNF signaling pathway_Homo sapiens_hsa046680.93789327
71Type II diabetes mellitus_Homo sapiens_hsa049300.93540332
72Carbohydrate digestion and absorption_Homo sapiens_hsa049730.92455086
73Sulfur relay system_Homo sapiens_hsa041220.92333441
74Toll-like receptor signaling pathway_Homo sapiens_hsa046200.91107059
75Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.91085390
76Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.90771266
77Thyroid hormone signaling pathway_Homo sapiens_hsa049190.89605654
78Chemokine signaling pathway_Homo sapiens_hsa040620.89529010
79Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.89224093
80RNA degradation_Homo sapiens_hsa030180.87550720
81MAPK signaling pathway_Homo sapiens_hsa040100.86701846
82Base excision repair_Homo sapiens_hsa034100.86674565
83Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.86512410
84Epstein-Barr virus infection_Homo sapiens_hsa051690.85955723
85Dorso-ventral axis formation_Homo sapiens_hsa043200.85817115
86Prolactin signaling pathway_Homo sapiens_hsa049170.85323842
87mRNA surveillance pathway_Homo sapiens_hsa030150.85201392
88Salivary secretion_Homo sapiens_hsa049700.83302421
89Gastric acid secretion_Homo sapiens_hsa049710.81947448
90Morphine addiction_Homo sapiens_hsa050320.81768884
91Axon guidance_Homo sapiens_hsa043600.81363198
92Viral myocarditis_Homo sapiens_hsa054160.80716968
93Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.80310689
94Maturity onset diabetes of the young_Homo sapiens_hsa049500.78882419
95Glutamatergic synapse_Homo sapiens_hsa047240.78389697
96Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.78058595
97FoxO signaling pathway_Homo sapiens_hsa040680.76459123
98Lysosome_Homo sapiens_hsa041420.74860945
99Calcium signaling pathway_Homo sapiens_hsa040200.74294514
100Glycerophospholipid metabolism_Homo sapiens_hsa005640.74219217
101Cell cycle_Homo sapiens_hsa041100.73950667
102Endometrial cancer_Homo sapiens_hsa052130.73428250
103Dopaminergic synapse_Homo sapiens_hsa047280.73353275
104Cocaine addiction_Homo sapiens_hsa050300.72204115
105Longevity regulating pathway - mammal_Homo sapiens_hsa042110.70417256
106Melanogenesis_Homo sapiens_hsa049160.69966172
107cAMP signaling pathway_Homo sapiens_hsa040240.69560647
108Sphingolipid signaling pathway_Homo sapiens_hsa040710.69175586
109Tuberculosis_Homo sapiens_hsa051520.69158681
110N-Glycan biosynthesis_Homo sapiens_hsa005100.69039710
111Adipocytokine signaling pathway_Homo sapiens_hsa049200.68277617
112Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.67589956
113cGMP-PKG signaling pathway_Homo sapiens_hsa040220.67509005
114Proteoglycans in cancer_Homo sapiens_hsa052050.67284885
115AMPK signaling pathway_Homo sapiens_hsa041520.66908509
116Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.66551521
117Insulin secretion_Homo sapiens_hsa049110.65164662
118Endocytosis_Homo sapiens_hsa041440.64880887
119Fructose and mannose metabolism_Homo sapiens_hsa000510.64545717
120Thyroid cancer_Homo sapiens_hsa052160.64100536
121Prostate cancer_Homo sapiens_hsa052150.63168431
122Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62566748
123Long-term depression_Homo sapiens_hsa047300.62499146
124Dilated cardiomyopathy_Homo sapiens_hsa054140.62281002
125RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.62155476
126Glucagon signaling pathway_Homo sapiens_hsa049220.62098859
127p53 signaling pathway_Homo sapiens_hsa041150.61931049
128Amphetamine addiction_Homo sapiens_hsa050310.61702974
129Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61432754
130RNA transport_Homo sapiens_hsa030130.60614693
131Glioma_Homo sapiens_hsa052140.58346235
132Rap1 signaling pathway_Homo sapiens_hsa040150.57753302
133Nicotine addiction_Homo sapiens_hsa050330.56979089
134Hepatitis C_Homo sapiens_hsa051600.56636650
135Vascular smooth muscle contraction_Homo sapiens_hsa042700.56300247
136Non-homologous end-joining_Homo sapiens_hsa034500.55181781
137Central carbon metabolism in cancer_Homo sapiens_hsa052300.55031356
138Focal adhesion_Homo sapiens_hsa045100.54745366
139Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.54351725
140Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53638359
141GABAergic synapse_Homo sapiens_hsa047270.53594891
142Taste transduction_Homo sapiens_hsa047420.53153137
143Alcoholism_Homo sapiens_hsa050340.51080033
144Pancreatic secretion_Homo sapiens_hsa049720.50915466
145Insulin signaling pathway_Homo sapiens_hsa049100.50767039
146Phospholipase D signaling pathway_Homo sapiens_hsa040720.49770426
147Bladder cancer_Homo sapiens_hsa052190.49577430

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