BRD9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.66189642
2neuron cell-cell adhesion (GO:0007158)5.19001867
3ionotropic glutamate receptor signaling pathway (GO:0035235)5.07209338
4nuclear pore organization (GO:0006999)4.68647742
5glutamate receptor signaling pathway (GO:0007215)4.67973986
6vocalization behavior (GO:0071625)4.65122791
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.53018269
8DNA unwinding involved in DNA replication (GO:0006268)4.42231222
9atrioventricular valve morphogenesis (GO:0003181)4.41898677
10mitotic chromosome condensation (GO:0007076)4.39602574
11chromosome condensation (GO:0030261)4.36061792
12protein localization to synapse (GO:0035418)4.32526036
13pore complex assembly (GO:0046931)4.22052841
14presynaptic membrane assembly (GO:0097105)4.11456534
15neuron recognition (GO:0008038)4.11054434
16synaptic transmission, glutamatergic (GO:0035249)4.08606899
17startle response (GO:0001964)4.05357859
18positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.00179169
19regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.99589982
20regulation of glutamate receptor signaling pathway (GO:1900449)3.96384925
21presynaptic membrane organization (GO:0097090)3.92177440
22DNA topological change (GO:0006265)3.91463655
23neuron-neuron synaptic transmission (GO:0007270)3.87479622
24regulation of NFAT protein import into nucleus (GO:0051532)3.86378705
25embryonic body morphogenesis (GO:0010172)3.84533096
26postsynaptic membrane organization (GO:0001941)3.83226142
27negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.81006485
28DNA duplex unwinding (GO:0032508)3.80216812
29synaptic vesicle exocytosis (GO:0016079)3.80069129
30DNA packaging (GO:0006323)3.79015620
31intracellular estrogen receptor signaling pathway (GO:0030520)3.78445827
32positive regulation of odontogenesis (GO:0042482)3.76394018
33ribosomal small subunit biogenesis (GO:0042274)3.76279123
34regulation of histone H3-K27 methylation (GO:0061085)3.73067380
35regulation of short-term neuronal synaptic plasticity (GO:0048172)3.71977191
36axonal fasciculation (GO:0007413)3.71164723
37gamma-aminobutyric acid signaling pathway (GO:0007214)3.67007987
38DNA conformation change (GO:0071103)3.65800267
39positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.61974502
40spliceosomal tri-snRNP complex assembly (GO:0000244)3.60327361
41DNA geometric change (GO:0032392)3.58112775
42regulation of translational fidelity (GO:0006450)3.56485829
43folic acid metabolic process (GO:0046655)3.54732351
44dosage compensation (GO:0007549)3.51952545
45G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.48159533
46tRNA methylation (GO:0030488)3.46050380
47neuronal action potential propagation (GO:0019227)3.44200693
48negative regulation of synaptic transmission, GABAergic (GO:0032229)3.41154287
49embryonic process involved in female pregnancy (GO:0060136)3.40825446
50regulation of RNA export from nucleus (GO:0046831)3.37098558
51mitotic sister chromatid segregation (GO:0000070)3.34655477
52regulation of excitatory postsynaptic membrane potential (GO:0060079)3.31753822
53positive regulation of synapse maturation (GO:0090129)3.30287016
54long-term memory (GO:0007616)3.28698595
55mannose metabolic process (GO:0006013)3.28471211
56regulation of mammary gland epithelial cell proliferation (GO:0033599)3.27035938
57negative regulation of erythrocyte differentiation (GO:0045647)3.26369030
58regulation of synapse maturation (GO:0090128)3.25866805
59positive regulation of synapse assembly (GO:0051965)3.24124558
60negative regulation of gene expression, epigenetic (GO:0045814)3.22819756
61exploration behavior (GO:0035640)3.18013715
62locomotory exploration behavior (GO:0035641)3.17449183
63transmission of nerve impulse (GO:0019226)3.16923994
64sister chromatid segregation (GO:0000819)3.13823223
65heterochromatin organization (GO:0070828)3.12636873
66ncRNA 3-end processing (GO:0043628)3.11823491
67formation of translation preinitiation complex (GO:0001731)3.10498680
68nucleosome disassembly (GO:0006337)3.09212584
69protein-DNA complex disassembly (GO:0032986)3.09212584
70snRNA metabolic process (GO:0016073)3.09176392
71dendritic spine morphogenesis (GO:0060997)3.08603617
72chromatin silencing (GO:0006342)3.07933159
73regulation of postsynaptic membrane potential (GO:0060078)3.07522319
74glucocorticoid receptor signaling pathway (GO:0042921)3.06676200
75body morphogenesis (GO:0010171)3.05318062
76DNA replication initiation (GO:0006270)3.03418165
77peptidyl-lysine dimethylation (GO:0018027)3.00181700
78mRNA stabilization (GO:0048255)2.99667235
79RNA stabilization (GO:0043489)2.99667235
80stress granule assembly (GO:0034063)2.99390852
81apoptotic process involved in morphogenesis (GO:0060561)2.99043929
82synaptic vesicle endocytosis (GO:0048488)2.98789730
83DNA replication checkpoint (GO:0000076)2.98552184
84meiotic chromosome segregation (GO:0045132)2.97627435
85negative regulation of mRNA processing (GO:0050686)2.95828169
86ribosome biogenesis (GO:0042254)2.94888490
87mitotic nuclear envelope disassembly (GO:0007077)2.94880602
88long-chain fatty acid biosynthetic process (GO:0042759)2.94855157
89nuclear envelope organization (GO:0006998)2.94820577
90central nervous system projection neuron axonogenesis (GO:0021952)2.93781250
91regulation of vesicle fusion (GO:0031338)2.93389598
92histone H4 deacetylation (GO:0070933)2.93215948
93positive regulation of membrane potential (GO:0045838)2.91913339
94regulation of synaptic vesicle exocytosis (GO:2000300)2.91026226
95behavioral defense response (GO:0002209)2.89697461
96behavioral fear response (GO:0001662)2.89697461
97regulation of nucleobase-containing compound transport (GO:0032239)2.89613911
98negative regulation of histone methylation (GO:0031061)2.89371297
99membrane disassembly (GO:0030397)2.89162289
100nuclear envelope disassembly (GO:0051081)2.89162289
101regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.89157428
102DNA strand elongation involved in DNA replication (GO:0006271)2.88898505
103response to laminar fluid shear stress (GO:0034616)2.88819678
104positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.88585447
105long-term synaptic potentiation (GO:0060291)2.87776733
106regulation of long-term neuronal synaptic plasticity (GO:0048169)2.87570590
107neurotransmitter-gated ion channel clustering (GO:0072578)2.87511044
108DNA strand elongation (GO:0022616)2.87272618
109response to histamine (GO:0034776)2.85701947
110cerebral cortex radially oriented cell migration (GO:0021799)2.85561171
111regulation of neuronal synaptic plasticity (GO:0048168)2.85079947
112corticosteroid receptor signaling pathway (GO:0031958)2.84030170
113regulation of monocyte differentiation (GO:0045655)2.81919368
114regulation of chromatin binding (GO:0035561)2.81765137
115negative regulation of mRNA metabolic process (GO:1903312)2.80878328
116UV protection (GO:0009650)2.80118691
117regulation of dendritic spine morphogenesis (GO:0061001)2.79712837
118regulation of synapse assembly (GO:0051963)2.79499497
119regulation of centriole replication (GO:0046599)2.79324902
120DNA synthesis involved in DNA repair (GO:0000731)2.78809559
121glutamate secretion (GO:0014047)2.78786196
1223-UTR-mediated mRNA stabilization (GO:0070935)2.78083753
123membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.76114172
124regulation of DNA damage checkpoint (GO:2000001)2.75903868
125dendrite development (GO:0016358)2.74735577
126modulation by virus of host process (GO:0019054)2.73842228
127central nervous system neuron axonogenesis (GO:0021955)2.73655530
128mitotic sister chromatid cohesion (GO:0007064)2.73073480
129learning (GO:0007612)2.72760646
130ribonucleoprotein complex biogenesis (GO:0022613)2.72328572
131regulation of synaptic transmission, glutamatergic (GO:0051966)2.70404761
132protein complex localization (GO:0031503)2.70299426
133positive regulation of dendritic spine morphogenesis (GO:0061003)2.69408693
134regulation of glutamate secretion (GO:0014048)2.69060346
135regulation of synaptic plasticity (GO:0048167)2.69035391
136snRNA processing (GO:0016180)2.68652158
137fear response (GO:0042596)2.68544669
138G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.67316201
139regulation of synaptic vesicle transport (GO:1902803)2.67235415
140membrane depolarization (GO:0051899)2.66512623
141synaptic vesicle docking involved in exocytosis (GO:0016081)2.65584178
142rRNA methylation (GO:0031167)2.65546142
143positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.65487545
144establishment of mitotic spindle localization (GO:0040001)2.65011294
145protein localization to cilium (GO:0061512)2.62420961
146mitotic G1/S transition checkpoint (GO:0044819)2.61228543
147microtubule depolymerization (GO:0007019)2.60313787
148serotonin receptor signaling pathway (GO:0007210)2.59310608
149cellular protein complex localization (GO:0034629)2.59307259
150mechanosensory behavior (GO:0007638)2.58215573
151limb bud formation (GO:0060174)2.57873045
152negative regulation of RNA splicing (GO:0033119)2.57329088
153positive regulation of neurotransmitter secretion (GO:0001956)2.57266400
154protein export from nucleus (GO:0006611)2.55696820
155dendritic spine organization (GO:0097061)2.55591349
156activation of Rac GTPase activity (GO:0032863)2.55535089
157telomere maintenance via semi-conservative replication (GO:0032201)2.55464327
158regulation of synapse organization (GO:0050807)2.54314746
159regulation of cell cycle checkpoint (GO:1901976)2.54148491
160positive regulation of DNA-dependent DNA replication (GO:2000105)2.53943119
161regulation of dendritic spine development (GO:0060998)2.53425883
162peptidyl-arginine omega-N-methylation (GO:0035247)2.53258653
163glycosphingolipid biosynthetic process (GO:0006688)2.53112309
164positive regulation of protein homodimerization activity (GO:0090073)2.52845044
165chaperone-mediated protein transport (GO:0072321)2.51615378
166negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.51259356
167regulation of respiratory gaseous exchange (GO:0043576)2.50955334
168histone H2B ubiquitination (GO:0033523)2.50626746
169regulation of respiratory system process (GO:0044065)2.50624113
170positive regulation by host of viral transcription (GO:0043923)2.50525229
171righting reflex (GO:0060013)2.50000676
172histone H4-K16 acetylation (GO:0043984)2.49854766
173cochlea development (GO:0090102)2.49641398
174synapse assembly (GO:0007416)2.49207110
175calcium-mediated signaling using intracellular calcium source (GO:0035584)2.49016100
176mitotic G1 DNA damage checkpoint (GO:0031571)2.48429159
177histone H3-K4 methylation (GO:0051568)2.47209016
178regulation of neuron projection regeneration (GO:0070570)2.47070699
179regulation of axon regeneration (GO:0048679)2.47070699
180transcription from RNA polymerase I promoter (GO:0006360)2.46384244
181regulation of neurotransmitter secretion (GO:0046928)2.46299721
182eyelid development in camera-type eye (GO:0061029)2.46279357
183histone phosphorylation (GO:0016572)2.46140688
184urea cycle (GO:0000050)2.45125098
185regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.43532211
186positive regulation of dendritic spine development (GO:0060999)2.41768075
187negative regulation of axon extension (GO:0030517)2.39379656
188cranial nerve structural organization (GO:0021604)2.37859763
189associative learning (GO:0008306)2.37803413
190negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.37704910
191regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.37181054
192cerebellar granule cell differentiation (GO:0021707)2.35617295
193regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.34316632
194negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.33530299
195negative regulation of cell killing (GO:0031342)2.33530299
196cell migration in hindbrain (GO:0021535)2.33042000
197synaptic transmission (GO:0007268)2.32186803
198cilium or flagellum-dependent cell motility (GO:0001539)2.31591176
199synaptic transmission, dopaminergic (GO:0001963)2.31397559
200detection of calcium ion (GO:0005513)2.31104292

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.76299476
2E2F7_22180533_ChIP-Seq_HELA_Human4.78182473
3GBX2_23144817_ChIP-Seq_PC3_Human4.00009218
4MYC_22102868_ChIP-Seq_BL_Human3.39268991
5VDR_21846776_ChIP-Seq_THP-1_Human3.34450162
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.28495213
7JARID2_20064375_ChIP-Seq_MESCs_Mouse3.27217710
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.94916465
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.78556942
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.74373258
11EED_16625203_ChIP-ChIP_MESCs_Mouse2.61069998
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.58431173
13TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.58293351
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.52856936
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.52800653
16RNF2_18974828_ChIP-Seq_MESCs_Mouse2.49816002
17EZH2_18974828_ChIP-Seq_MESCs_Mouse2.49816002
18KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.45887161
19TAF15_26573619_Chip-Seq_HEK293_Human2.43803160
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.41123079
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.41114783
22MYC_18555785_ChIP-Seq_MESCs_Mouse2.34986593
23LXR_22292898_ChIP-Seq_THP-1_Human2.34921202
24KDM2B_26808549_Chip-Seq_SUP-B15_Human2.26097760
25CBX2_27304074_Chip-Seq_ESCs_Mouse2.25315893
26REST_21632747_ChIP-Seq_MESCs_Mouse2.23701116
27* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.23042797
28KDM2B_26808549_Chip-Seq_DND41_Human2.14901965
29ZFP57_27257070_Chip-Seq_ESCs_Mouse2.14560214
30CTBP1_25329375_ChIP-Seq_LNCAP_Human2.13590359
31TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.10796770
32EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.07947760
33RNF2_27304074_Chip-Seq_ESCs_Mouse2.07647052
34TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.06527449
35ELK3_25401928_ChIP-Seq_HUVEC_Human2.06288581
36MTF2_20144788_ChIP-Seq_MESCs_Mouse2.05607775
37CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.03185197
38BMI1_23680149_ChIP-Seq_NPCS_Mouse2.03165046
39EGR1_19374776_ChIP-ChIP_THP-1_Human1.99892849
40ZNF263_19887448_ChIP-Seq_K562_Human1.98575021
41EZH2_27294783_Chip-Seq_ESCs_Mouse1.97581231
42PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.96162873
43SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.95321106
44RACK7_27058665_Chip-Seq_MCF-7_Human1.95177836
45SUZ12_27294783_Chip-Seq_ESCs_Mouse1.94595521
46TCF7_22412390_ChIP-Seq_EML_Mouse1.94151988
47EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.92789564
48IKZF1_21737484_ChIP-ChIP_HCT116_Human1.92124343
49XRN2_22483619_ChIP-Seq_HELA_Human1.90683823
50CTBP2_25329375_ChIP-Seq_LNCAP_Human1.90169490
51FUS_26573619_Chip-Seq_HEK293_Human1.87139395
52POU3F2_20337985_ChIP-ChIP_501MEL_Human1.82230516
53FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.79006019
54RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.78151207
55P68_20966046_ChIP-Seq_HELA_Human1.77968283
56CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.74244937
57KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.71582787
58MAF_26560356_Chip-Seq_TH2_Human1.69753545
59* SMC4_20622854_ChIP-Seq_HELA_Human1.68161364
60REST_18959480_ChIP-ChIP_MESCs_Mouse1.67913072
61STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.67248554
62NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.66890864
63P300_19829295_ChIP-Seq_ESCs_Human1.66122249
64NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.65794800
65CIITA_25753668_ChIP-Seq_RAJI_Human1.65431319
66GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.64615125
67MAF_26560356_Chip-Seq_TH1_Human1.63644864
68PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.62491387
69RARB_27405468_Chip-Seq_BRAIN_Mouse1.61906153
70SMAD4_21799915_ChIP-Seq_A2780_Human1.61904068
71SMAD3_21741376_ChIP-Seq_EPCs_Human1.60736576
72VDR_24763502_ChIP-Seq_THP-1_Human1.59652714
73CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.58859956
74RNF2_27304074_Chip-Seq_NSC_Mouse1.58549195
75SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.58133884
76CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.58095253
77AR_21572438_ChIP-Seq_LNCaP_Human1.57665544
78UTX_26944678_Chip-Seq_JUKART_Human1.57059843
79MYC_18358816_ChIP-ChIP_MESCs_Mouse1.56590422
80VDR_22108803_ChIP-Seq_LS180_Human1.56337674
81KDM2B_26808549_Chip-Seq_JURKAT_Human1.53609695
82MYC_19079543_ChIP-ChIP_MESCs_Mouse1.50653277
83KDM2B_26808549_Chip-Seq_K562_Human1.50386576
84ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.48195233
85RARG_19884340_ChIP-ChIP_MEFs_Mouse1.47771760
86ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.47520396
87DROSHA_22980978_ChIP-Seq_HELA_Human1.47352598
88MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.45301873
89TET1_21451524_ChIP-Seq_MESCs_Mouse1.44902496
90IGF1R_20145208_ChIP-Seq_DFB_Human1.44841543
91MYC_19030024_ChIP-ChIP_MESCs_Mouse1.43543967
92TOP2B_26459242_ChIP-Seq_MCF-7_Human1.42037848
93ZNF274_21170338_ChIP-Seq_K562_Hela1.41916079
94* NCOR1_26117541_ChIP-Seq_K562_Human1.41377441
95OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40327212
96E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.39867439
97THAP11_20581084_ChIP-Seq_MESCs_Mouse1.38554251
98FLI1_27457419_Chip-Seq_LIVER_Mouse1.36968300
99TP63_17297297_ChIP-ChIP_HaCaT_Human1.36367557
100SA1_27219007_Chip-Seq_ERYTHROID_Human1.36186739
101CTCF_27219007_Chip-Seq_ERYTHROID_Human1.34778780
102BCOR_27268052_Chip-Seq_Bcells_Human1.33699884
103E2F4_17652178_ChIP-ChIP_JURKAT_Human1.31585944
104NANOG_18555785_Chip-Seq_ESCs_Mouse1.30276788
105MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.29555152
106KDM5A_27292631_Chip-Seq_BREAST_Human1.28946109
107CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28940603
108TP53_22127205_ChIP-Seq_IMR90_Human1.28509119
109CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.28423418
110EWS_26573619_Chip-Seq_HEK293_Human1.27917725
111MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.27751048
112PKCTHETA_26484144_Chip-Seq_BREAST_Human1.27671421
113PCGF2_27294783_Chip-Seq_ESCs_Mouse1.27472159
114ELF1_20517297_ChIP-Seq_JURKAT_Human1.26566725
115* ERG_21242973_ChIP-ChIP_JURKAT_Human1.26473856
116* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.26314347
117UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.26219676
118SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26035107
119HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.25435434
120POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.25254512
121TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.24598305
122BCL6_27268052_Chip-Seq_Bcells_Human1.24027760
123ATF3_27146783_Chip-Seq_COLON_Human1.23635546
124PRDM14_20953172_ChIP-Seq_ESCs_Human1.23476580
125UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.22716886
126TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.21822170
127CREB1_26743006_Chip-Seq_LNCaP_Human1.21777358
128JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.21745100
129GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.21577961
130POU5F1_16153702_ChIP-ChIP_HESCs_Human1.21498820
131RUNX1_27514584_Chip-Seq_MCF-7_Human1.20876079
132ER_23166858_ChIP-Seq_MCF-7_Human1.20709894
133DCP1A_22483619_ChIP-Seq_HELA_Human1.20572109
134SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19938023
135TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19795575
136PIAS1_25552417_ChIP-Seq_VCAP_Human1.19601281
137KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.18769592
138E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.18769454
139* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.18200167
140P300_27058665_Chip-Seq_ZR-75-30cells_Human1.16262583
141E2F1_21310950_ChIP-Seq_MCF-7_Human1.15543843
142AR_25329375_ChIP-Seq_VCAP_Human1.15365249
143TTF2_22483619_ChIP-Seq_HELA_Human1.14995042
144KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.14503177
145TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.14023314
146BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.13730599
147PHF8_20622854_ChIP-Seq_HELA_Human1.13684765
148EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13367549
149STAT6_21828071_ChIP-Seq_BEAS2B_Human1.13357685
150POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12721073
151TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12721073
152YY1_21170310_ChIP-Seq_MESCs_Mouse1.11227456
153CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.10753460
154NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.10652185
155CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.10336751
156E2F1_18555785_Chip-Seq_ESCs_Mouse1.10165967
157RUNX2_22187159_ChIP-Seq_PCA_Human1.09787770
158ZFX_18555785_ChIP-Seq_MESCs_Mouse1.09526583
159VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.09318729
160ESR1_15608294_ChIP-ChIP_MCF-7_Human1.08388407
161CTCF_21964334_Chip-Seq_Bcells_Human1.08258050
162ZFP281_18757296_ChIP-ChIP_E14_Mouse1.08225516
163* GABP_19822575_ChIP-Seq_HepG2_Human1.08009951
164CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.07506781
165TCF4_23295773_ChIP-Seq_U87_Human1.07359304
166SMAD_19615063_ChIP-ChIP_OVARY_Human1.07231244
167MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07180186
168KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.07169414
169RUNX1_22412390_ChIP-Seq_EML_Mouse1.06424888
170RING1B_27294783_Chip-Seq_ESCs_Mouse1.05999261
171BRD4_27068464_Chip-Seq_AML-cells_Mouse1.05674289
172MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.05076410
173UBF1/2_26484160_Chip-Seq_HMECs_Human1.04961288
174STAT3_1855785_ChIP-Seq_MESCs_Mouse1.04767364
175ETS1_20019798_ChIP-Seq_JURKAT_Human1.04315269
176P53_22387025_ChIP-Seq_ESCs_Mouse1.03863185
177STAT3_23295773_ChIP-Seq_U87_Human1.03263392
178ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.02872321
179SOX9_26525672_Chip-Seq_HEART_Mouse1.02673593
180TP63_19390658_ChIP-ChIP_HaCaT_Human1.02276084
181CMYC_18555785_Chip-Seq_ESCs_Mouse1.02190146
182MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.02156648
183JUN_21703547_ChIP-Seq_K562_Human1.01969548
184P53_22127205_ChIP-Seq_FIBROBLAST_Human1.01780492
185FOXP1_21924763_ChIP-Seq_HESCs_Human1.01323484
186NELFA_20434984_ChIP-Seq_ESCs_Mouse1.01317979
187RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.00809057
188SOX2_21211035_ChIP-Seq_LN229_Gbm1.00597192
189EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.98895749
190FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.98890793
191SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98147097
192RING1B_27294783_Chip-Seq_NPCs_Mouse0.97674799
193HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.93952942
194NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92791289
195SUZ12_27294783_Chip-Seq_NPCs_Mouse0.92046301
196TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91696999
197STAT3_18555785_Chip-Seq_ESCs_Mouse0.91207623
198P300_18555785_Chip-Seq_ESCs_Mouse0.90736412
199CDX2_19796622_ChIP-Seq_MESCs_Mouse0.90330511
200SOX2_18555785_Chip-Seq_ESCs_Mouse0.90305010

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.68073501
2MP0004859_abnormal_synaptic_plasticity4.57948824
3MP0005076_abnormal_cell_differentiation4.46738308
4MP0003635_abnormal_synaptic_transmissio3.24407278
5MP0005083_abnormal_biliary_tract3.23589856
6MP0003693_abnormal_embryo_hatching3.14697031
7MP0003111_abnormal_nucleus_morphology3.09170509
8MP0004233_abnormal_muscle_weight3.04288361
9MP0001968_abnormal_touch/_nociception3.03794126
10MP0010094_abnormal_chromosome_stability3.03269470
11MP0002736_abnormal_nociception_after2.94385864
12MP0009745_abnormal_behavioral_response2.91300186
13MP0003077_abnormal_cell_cycle2.84331607
14MP0002063_abnormal_learning/memory/cond2.71318555
15MP0004270_analgesia2.70215167
16MP0005451_abnormal_body_composition2.62871752
17MP0009278_abnormal_bone_marrow2.57626973
18MP0001188_hyperpigmentation2.57400741
19MP0002064_seizures2.54938414
20MP0003705_abnormal_hypodermis_morpholog2.48985263
21MP0002735_abnormal_chemical_nociception2.46739616
22MP0003787_abnormal_imprinting2.46634853
23MP0005423_abnormal_somatic_nervous2.44234595
24MP0008057_abnormal_DNA_replication2.42588461
25MP0002572_abnormal_emotion/affect_behav2.40604429
26MP0004808_abnormal_hematopoietic_stem2.39822512
27MP0001348_abnormal_lacrimal_gland2.32280671
28MP0002877_abnormal_melanocyte_morpholog2.29917078
29MP0003763_abnormal_thymus_physiology2.27710998
30MP0002272_abnormal_nervous_system2.27641965
31MP0009046_muscle_twitch2.25910007
32MP0004957_abnormal_blastocyst_morpholog2.24710936
33MP0000778_abnormal_nervous_system2.20472169
34MP0001486_abnormal_startle_reflex2.15918299
35MP0002734_abnormal_mechanical_nocicepti2.12314664
36MP0006292_abnormal_olfactory_placode2.11187866
37MP0002396_abnormal_hematopoietic_system2.09514270
38MP0006276_abnormal_autonomic_nervous2.08212255
39MP0001440_abnormal_grooming_behavior2.01739265
40MP0001501_abnormal_sleep_pattern2.01069794
41MP0000003_abnormal_adipose_tissue1.98777029
42MP0002184_abnormal_innervation1.94080219
43MP0002067_abnormal_sensory_capabilities1.89327115
44MP0005409_darkened_coat_color1.79138822
45MP0008932_abnormal_embryonic_tissue1.78129390
46MP0010307_abnormal_tumor_latency1.75131426
47MP0001905_abnormal_dopamine_level1.74268818
48MP0001529_abnormal_vocalization1.73520742
49MP0004185_abnormal_adipocyte_glucose1.71750204
50MP0008058_abnormal_DNA_repair1.70654017
51MP0001970_abnormal_pain_threshold1.64554274
52MP0001730_embryonic_growth_arrest1.59337725
53MP0002733_abnormal_thermal_nociception1.58068059
54MP0001849_ear_inflammation1.54029564
55MP0002557_abnormal_social/conspecific_i1.53866037
56MP0005171_absent_coat_pigmentation1.53768301
57MP0000350_abnormal_cell_proliferation1.53043779
58MP0010030_abnormal_orbit_morphology1.49979636
59MP0004742_abnormal_vestibular_system1.49627348
60MP0002080_prenatal_lethality1.44193282
61MP0003984_embryonic_growth_retardation1.42084633
62MP0005621_abnormal_cell_physiology1.37362898
63MP0003938_abnormal_ear_development1.37077543
64MP0001672_abnormal_embryogenesis/_devel1.36477808
65MP0005380_embryogenesis_phenotype1.36477808
66MP0003879_abnormal_hair_cell1.35896262
67MP0000015_abnormal_ear_pigmentation1.35201560
68MP0000490_abnormal_crypts_of1.33352976
69MP0002088_abnormal_embryonic_growth/wei1.32700389
70MP0000703_abnormal_thymus_morphology1.32354687
71MP0002638_abnormal_pupillary_reflex1.32063548
72MP0002882_abnormal_neuron_morphology1.30536635
73MP0005375_adipose_tissue_phenotype1.28284970
74MP0002822_catalepsy1.27836415
75MP0000313_abnormal_cell_death1.27306694
76MP0003453_abnormal_keratinocyte_physiol1.27164129
77MP0002089_abnormal_postnatal_growth/wei1.26899705
78MP0002102_abnormal_ear_morphology1.26704106
79MP0004811_abnormal_neuron_physiology1.24057353
80MP0004924_abnormal_behavior1.22133083
81MP0005386_behavior/neurological_phenoty1.22133083
82MP0008569_lethality_at_weaning1.21988717
83MP0004947_skin_inflammation1.21979916
84MP0003786_premature_aging1.21575967
85MP0008961_abnormal_basal_metabolism1.20135841
86MP0001873_stomach_inflammation1.18299348
87MP0003566_abnormal_cell_adhesion1.18287218
88MP0004142_abnormal_muscle_tone1.17906379
89MP0000733_abnormal_muscle_development1.15943473
90MP0002066_abnormal_motor_capabilities/c1.15922897
91MP0003091_abnormal_cell_migration1.15580976
92MP0001502_abnormal_circadian_rhythm1.13801026
93MP0002086_abnormal_extraembryonic_tissu1.13731434
94MP0002019_abnormal_tumor_incidence1.13119257
95MP0005645_abnormal_hypothalamus_physiol1.12947479
96MP0000955_abnormal_spinal_cord1.12701166
97MP0000678_abnormal_parathyroid_gland1.11145451
98MP0008007_abnormal_cellular_replicative1.10937523
99MP0003136_yellow_coat_color1.09402067
100MP0002152_abnormal_brain_morphology1.08471205
101MP0005501_abnormal_skin_physiology1.08381937
102MP0000026_abnormal_inner_ear1.07303615
103MP0010386_abnormal_urinary_bladder1.05991309
104MP0001697_abnormal_embryo_size1.05056006
105MP0009672_abnormal_birth_weight1.04579053
106MP0001963_abnormal_hearing_physiology1.04417647
107MP0004145_abnormal_muscle_electrophysio1.02708139
108MP0000750_abnormal_muscle_regeneration1.02353141
109MP0005384_cellular_phenotype1.01831650
110MP0000759_abnormal_skeletal_muscle1.01793342
111MP0003122_maternal_imprinting1.01786080
112MP0002752_abnormal_somatic_nervous1.01303226
113MP0008995_early_reproductive_senescence1.01238278
114MP0001485_abnormal_pinna_reflex1.00935486
115MP0001984_abnormal_olfaction1.00838319
116MP0002398_abnormal_bone_marrow0.99728364
117MP0004197_abnormal_fetal_growth/weight/0.99686380
118MP0005623_abnormal_meninges_morphology0.98720539
119MP0005666_abnormal_adipose_tissue0.98534065
120MP0008877_abnormal_DNA_methylation0.98363316
121MP0002085_abnormal_embryonic_tissue0.96384493
122MP0009333_abnormal_splenocyte_physiolog0.94950625
123MP0000631_abnormal_neuroendocrine_gland0.93720025
124MP0009379_abnormal_foot_pigmentation0.93365578
125MP0005197_abnormal_uvea_morphology0.92926388
126MP0002722_abnormal_immune_system0.92362267
127MP0002876_abnormal_thyroid_physiology0.92295978
128MP0005646_abnormal_pituitary_gland0.92200190
129MP0001851_eye_inflammation0.92097546
130MP0005551_abnormal_eye_electrophysiolog0.91603036
131MP0002970_abnormal_white_adipose0.91494442
132MP0003436_decreased_susceptibility_to0.90596171
133MP0005397_hematopoietic_system_phenotyp0.89476388
134MP0001545_abnormal_hematopoietic_system0.89476388
135MP0005394_taste/olfaction_phenotype0.89441201
136MP0005499_abnormal_olfactory_system0.89441201
137MP0002909_abnormal_adrenal_gland0.88717748
138MP0003329_amyloid_beta_deposits0.88204002
139MP0003121_genomic_imprinting0.87927659
140MP0000358_abnormal_cell_content/0.86645948
141MP0002933_joint_inflammation0.86223621
142MP0009780_abnormal_chondrocyte_physiolo0.84535667
143MP0004885_abnormal_endolymph0.84372641
144MP0009931_abnormal_skin_appearance0.83816639
145MP0002084_abnormal_developmental_patter0.83031886
146MP0002751_abnormal_autonomic_nervous0.82358877
147MP0004484_altered_response_of0.82279240
148MP0003115_abnormal_respiratory_system0.81626508
149MP0002163_abnormal_gland_morphology0.80641147
150MP0002837_dystrophic_cardiac_calcinosis0.80361265
151MP0000013_abnormal_adipose_tissue0.80161122
152MP0003861_abnormal_nervous_system0.79971612
153MP0000751_myopathy0.78000922
154MP0002092_abnormal_eye_morphology0.76983065
155MP0002060_abnormal_skin_morphology0.76269610
156MP0002697_abnormal_eye_size0.75629575
157MP0000579_abnormal_nail_morphology0.75509790
158MP0006072_abnormal_retinal_apoptosis0.74363113
159MP0000920_abnormal_myelination0.74024393
160MP0000367_abnormal_coat/_hair0.73727051
161MP0002429_abnormal_blood_cell0.73697719
162MP0001216_abnormal_epidermal_layer0.73567536
163MP0004085_abnormal_heartbeat0.73531621
164MP0010630_abnormal_cardiac_muscle0.72939000
165MP0001664_abnormal_digestion0.72718006
166MP0005257_abnormal_intraocular_pressure0.71939061
167MP0004858_abnormal_nervous_system0.71590355
168MP0008260_abnormal_autophagy0.71087073
169MP0003385_abnormal_body_wall0.70574002
170MP0000428_abnormal_craniofacial_morphol0.70490663
171MP0002796_impaired_skin_barrier0.70457681
172MP0002229_neurodegeneration0.69143018
173MP0002095_abnormal_skin_pigmentation0.69072310
174MP0006035_abnormal_mitochondrial_morpho0.68982259
175MP0004510_myositis0.67543614
176MP0004087_abnormal_muscle_fiber0.67329132
177MP0000858_altered_metastatic_potential0.67176895
178MP0000049_abnormal_middle_ear0.67027827
179MP0003123_paternal_imprinting0.66771397
180MP0000569_abnormal_digit_pigmentation0.66157357
181MP0005058_abnormal_lysosome_morphology0.65454730
182MP0005174_abnormal_tail_pigmentation0.65108982
183MP0005410_abnormal_fertilization0.61913499
184MP0004215_abnormal_myocardial_fiber0.59603327
185MP0003631_nervous_system_phenotype0.59587735
186MP0008789_abnormal_olfactory_epithelium0.59229361
187MP0003137_abnormal_impulse_conducting0.59059597
188MP0004381_abnormal_hair_follicle0.57881165
189MP0009250_abnormal_appendicular_skeleto0.57574093
190MP0002069_abnormal_eating/drinking_beha0.56643311
191MP0002249_abnormal_larynx_morphology0.53980743

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.42879320
2Focal seizures (HP:0007359)4.02837890
3Epileptic encephalopathy (HP:0200134)3.98602561
4Progressive muscle weakness (HP:0003323)3.96796964
5Febrile seizures (HP:0002373)3.95035984
6Atonic seizures (HP:0010819)3.92368895
7Microvesicular hepatic steatosis (HP:0001414)3.65278325
8Hyperventilation (HP:0002883)3.59184429
9Broad face (HP:0000283)3.55258060
10Broad-based gait (HP:0002136)3.48410363
11Hyperacusis (HP:0010780)3.29476615
12Ulnar bowing (HP:0003031)3.28193846
13Progressive cerebellar ataxia (HP:0002073)3.27845956
14Ragged-red muscle fibers (HP:0003200)3.25031985
15Myokymia (HP:0002411)3.21504843
16Deep philtrum (HP:0002002)3.11831751
17Visual hallucinations (HP:0002367)3.08519509
18Cerebellar dysplasia (HP:0007033)3.07327675
19Squamous cell carcinoma (HP:0002860)3.05420943
20Chromosomal breakage induced by crosslinking agents (HP:0003221)3.03346794
21Absence seizures (HP:0002121)2.93086607
22Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.91642255
23Abnormality of DNA repair (HP:0003254)2.91551407
24Abnormality of the nasal septum (HP:0000419)2.91534751
25Dialeptic seizures (HP:0011146)2.88811915
26Broad distal phalanx of finger (HP:0009836)2.84071471
27Gait imbalance (HP:0002141)2.79116542
28Dynein arm defect of respiratory motile cilia (HP:0012255)2.72533435
29Absent/shortened dynein arms (HP:0200106)2.72533435
30Progressive external ophthalmoplegia (HP:0000590)2.71414165
31Short nail (HP:0001799)2.70349402
32Flared metaphyses (HP:0003015)2.69294892
33Amblyopia (HP:0000646)2.67185718
34Medial flaring of the eyebrow (HP:0010747)2.66767250
35Poikiloderma (HP:0001029)2.65494746
36Lip pit (HP:0100267)2.56986806
37Abnormality of the fingertips (HP:0001211)2.56278537
38Achilles tendon contracture (HP:0001771)2.54096306
39Gaze-evoked nystagmus (HP:0000640)2.52527511
40Sparse lateral eyebrow (HP:0005338)2.52418741
41Chromsome breakage (HP:0040012)2.51101440
42Congenital primary aphakia (HP:0007707)2.48718905
43Proximal placement of thumb (HP:0009623)2.46112515
44Nephrogenic diabetes insipidus (HP:0009806)2.45822699
45Protruding tongue (HP:0010808)2.44098115
46Acute necrotizing encephalopathy (HP:0006965)2.41523765
47Aplasia/Hypoplasia of the sacrum (HP:0008517)2.41080916
48Dislocated radial head (HP:0003083)2.39844567
49Deviation of the thumb (HP:0009603)2.37983605
50Nasal speech (HP:0001611)2.36958277
51Reticulocytopenia (HP:0001896)2.36075071
52Increased connective tissue (HP:0009025)2.34270251
53Long palpebral fissure (HP:0000637)2.33549271
54Progressive inability to walk (HP:0002505)2.32245415
55Abnormal respiratory motile cilium morphology (HP:0005938)2.31672789
56Abnormal respiratory epithelium morphology (HP:0012253)2.31672789
57Abnormal hair whorl (HP:0010721)2.31506392
58Sparse scalp hair (HP:0002209)2.29912794
59Generalized tonic-clonic seizures (HP:0002069)2.28339606
60Distal lower limb amyotrophy (HP:0008944)2.28069752
61Excessive salivation (HP:0003781)2.27422653
62Drooling (HP:0002307)2.27422653
63Absent speech (HP:0001344)2.27071850
64Retinal dysplasia (HP:0007973)2.25087969
65Elbow flexion contracture (HP:0002987)2.20703086
66Breast hypoplasia (HP:0003187)2.20543166
67Ankyloglossia (HP:0010296)2.18495947
68Inability to walk (HP:0002540)2.17147057
69Vaginal atresia (HP:0000148)2.15770277
70Aplasia cutis congenita (HP:0001057)2.14950645
71Thin ribs (HP:0000883)2.14832298
72Abnormality of the radial head (HP:0003995)2.14366517
73Gingivitis (HP:0000230)2.14304769
74Genital tract atresia (HP:0001827)2.14006293
75Short tibia (HP:0005736)2.12292054
76Stomach cancer (HP:0012126)2.10155667
77Nasolacrimal duct obstruction (HP:0000579)2.09796642
78Spina bifida occulta (HP:0003298)2.09613089
79Pointed chin (HP:0000307)2.09273230
80Supernumerary nipples (HP:0002558)2.07262523
81Duplicated collecting system (HP:0000081)2.06770327
82Abnormality of the distal phalanx of the thumb (HP:0009617)2.06291695
83Metaphyseal cupping (HP:0003021)2.03931693
84Abnormality of the calcaneus (HP:0008364)2.02519656
85Progressive macrocephaly (HP:0004481)2.02456454
86Prominent nose (HP:0000448)2.02343310
87Heterotopia (HP:0002282)2.02240107
88Hemiparesis (HP:0001269)2.01962658
89Mitochondrial inheritance (HP:0001427)2.01743573
90Short thumb (HP:0009778)2.01632881
91Long eyelashes (HP:0000527)2.01342262
92Abnormality of oral frenula (HP:0000190)2.01153529
93Periodontitis (HP:0000704)2.00815173
94Truncal ataxia (HP:0002078)2.00451149
95Bowed forearm bones (HP:0003956)2.00442081
96Bowing of the arm (HP:0006488)2.00442081
97Scanning speech (HP:0002168)1.99555014
98Abnormal number of incisors (HP:0011064)1.99395636
99Hypergonadotropic hypogonadism (HP:0000815)1.99307118
100Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.98827166
101Birth length less than 3rd percentile (HP:0003561)1.98611088
102Delusions (HP:0000746)1.98273969
103Abnormal ciliary motility (HP:0012262)1.98242191
104Abnormality of the Achilles tendon (HP:0005109)1.97494600
105Diplopia (HP:0000651)1.97384279
106Abnormality of binocular vision (HP:0011514)1.97384279
107Entropion (HP:0000621)1.97023070
108Bowel incontinence (HP:0002607)1.96881865
109Milia (HP:0001056)1.96364834
110Fetal akinesia sequence (HP:0001989)1.96097508
111Intestinal fistula (HP:0100819)1.95153995
112Congenital malformation of the right heart (HP:0011723)1.94627933
113Double outlet right ventricle (HP:0001719)1.94627933
114Blue irides (HP:0000635)1.93356569
115Increased hepatocellular lipid droplets (HP:0006565)1.93017609
116Centrally nucleated skeletal muscle fibers (HP:0003687)1.92967680
117Abnormality of the aortic arch (HP:0012303)1.92863667
118Limb dystonia (HP:0002451)1.92776097
119Mutism (HP:0002300)1.92367730
120Ureteral duplication (HP:0000073)1.91559786
121Optic nerve coloboma (HP:0000588)1.91205259
122Ectopic kidney (HP:0000086)1.91112141
123Aplasia/Hypoplasia of the tibia (HP:0005772)1.90545347
124Tented upper lip vermilion (HP:0010804)1.90279268
125Trigonocephaly (HP:0000243)1.90092234
126Abnormal respiratory motile cilium physiology (HP:0012261)1.89492755
127Abnormal mitochondria in muscle tissue (HP:0008316)1.88569245
128Abnormality of salivation (HP:0100755)1.88072147
129Fragile skin (HP:0001030)1.86613331
130Supernumerary ribs (HP:0005815)1.86171471
131Abnormal large intestine physiology (HP:0012700)1.85647482
132Oligodactyly (hands) (HP:0001180)1.85179856
133Recurrent gram-negative bacterial infections (HP:0005420)1.85112822
134Narrow nasal bridge (HP:0000446)1.84657942
135Cellulitis (HP:0100658)1.84278305
136Hydroureter (HP:0000072)1.84064477
137Dysmetria (HP:0001310)1.83988322
138Poor coordination (HP:0002370)1.83830300
139Abnormality of pyrimidine metabolism (HP:0004353)1.83769191
140Esotropia (HP:0000565)1.82391976
141Annular pancreas (HP:0001734)1.82078635
142Thickened helices (HP:0000391)1.82027774
143Abnormality of cochlea (HP:0000375)1.81299331
144Abnormality of the intervertebral disk (HP:0005108)1.80687586
14511 pairs of ribs (HP:0000878)1.80277232
146Supranuclear gaze palsy (HP:0000605)1.79325715
147Aplasia/Hypoplasia of the lens (HP:0008063)1.78889527
148Difficulty climbing stairs (HP:0003551)1.78139796
149Aplasia/Hypoplasia of the brainstem (HP:0007362)1.77504221
150Hypoplasia of the brainstem (HP:0002365)1.77504221
151Abnormality of the renal collecting system (HP:0004742)1.75724052
152Optic disc pallor (HP:0000543)1.75122915
153Absent radius (HP:0003974)1.74591709
154Calcaneovalgus deformity (HP:0001848)1.74473537
155Nephronophthisis (HP:0000090)1.74426687
156Gastroesophageal reflux (HP:0002020)1.74052602
157Exotropia (HP:0000577)1.73537757
158Sandal gap (HP:0001852)1.72927256
159Anophthalmia (HP:0000528)1.72820860
160Morphological abnormality of the middle ear (HP:0008609)1.72017961
161Heterochromia iridis (HP:0001100)1.71870039
162Polyphagia (HP:0002591)1.71601879
163Down-sloping shoulders (HP:0200021)1.71442203
164Partial agenesis of the corpus callosum (HP:0001338)1.71354102
165Genetic anticipation (HP:0003743)1.70566453
166Abnormality of the humeroradial joint (HP:0100744)1.70249741
167Selective tooth agenesis (HP:0001592)1.69900492
168Supernumerary bones of the axial skeleton (HP:0009144)1.69760449
169Duplication of thumb phalanx (HP:0009942)1.69449604
170Deep palmar crease (HP:0006191)1.68789008
171Urethral obstruction (HP:0000796)1.68686357
172Trismus (HP:0000211)1.67528101
173Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.67308801
174Colitis (HP:0002583)1.66358439
175Impaired smooth pursuit (HP:0007772)1.65344424
176Cupped ribs (HP:0000887)1.64942227
177Widely spaced teeth (HP:0000687)1.64820071
178External ophthalmoplegia (HP:0000544)1.64052240
179Persistence of primary teeth (HP:0006335)1.63347014
180Basal cell carcinoma (HP:0002671)1.62746800
181Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.62602021
182True hermaphroditism (HP:0010459)1.62002452
183Abnormality of midbrain morphology (HP:0002418)1.61895975
184Molar tooth sign on MRI (HP:0002419)1.61895975
185Renal Fanconi syndrome (HP:0001994)1.61879577
186Generalized hypopigmentation of hair (HP:0011358)1.60700056
187Abnormality of the labia minora (HP:0012880)1.60375847
188Pancreatic fibrosis (HP:0100732)1.59089280
189Neoplasm of the adrenal cortex (HP:0100641)1.58258470
190Fair hair (HP:0002286)1.57370906
191Specific learning disability (HP:0001328)1.55480224
192Volvulus (HP:0002580)1.53016244
193Cupped ear (HP:0000378)1.52855298
194Narrow forehead (HP:0000341)1.52643033
195Degeneration of the lateral corticospinal tracts (HP:0002314)1.52440228
196Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.52440228
197Increased CSF lactate (HP:0002490)1.49616156
198Aganglionic megacolon (HP:0002251)1.48531373
199Epileptiform EEG discharges (HP:0011182)1.47871259
200Anencephaly (HP:0002323)1.47191451

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.36425448
2EPHA44.12044889
3CDK123.95177856
4NTRK33.93528386
5PDK23.69506165
6TRIB33.47247208
7TNIK2.97938893
8PIM22.97820052
9RIPK42.87528507
10MST1R2.74070168
11MAP3K122.61026945
12MARK12.55604034
13SMG12.41491563
14PLK22.33905153
15MAP2K72.30901302
16PBK2.24419803
17EEF2K2.18701483
18MAPK132.18689208
19PNCK2.15498864
20MAP3K102.10641581
21TAOK21.98395482
22SIK11.94930022
23MAP3K41.94327459
24STK161.87003072
25MAP4K11.85346429
26NTRK21.80513654
27MKNK21.72453706
28GRK71.66911959
29MINK11.64671035
30GRK51.58392036
31FES1.55239395
32* MTOR1.54190878
33NME21.51165870
34MAPK111.48978578
35BMPR21.48420805
36ZAK1.48098185
37PRPF4B1.47625187
38SIK21.46826394
39TTN1.45648386
40NME11.43500647
41FGR1.39043307
42CDK191.38553773
43CAMK2B1.37326159
44CDC71.33852576
45CDK41.33342444
46IRAK31.32190891
47CCNB11.18785995
48MAP3K81.18005377
49PKN21.16676010
50RAF11.16611638
51DAPK11.15947704
52MAP2K31.15526267
53CAMK2A1.13178496
54DYRK1A1.12275927
55UHMK11.10568590
56NEK21.10037121
57PTK2B1.08126763
58FGFR41.06211345
59TESK21.02713374
60EPHA21.01457894
61RPS6KB21.01381028
62ERN11.00895067
63MKNK10.99177548
64MAP3K70.98883847
65PRKCG0.97715098
66CDK50.97675756
67MAPK150.97281348
68CSNK1G20.97168292
69EPHB10.96357627
70ATR0.94373187
71CAMK1D0.94366172
72BRD40.94130951
73RIPK10.93411420
74PKN10.92276835
75OXSR10.91996422
76ARAF0.91989482
77MAP3K90.91966723
78CDK30.91414739
79SRPK10.88690891
80CDK70.87735338
81PDPK10.87117114
82AURKA0.83809346
83MAP3K10.82908604
84MAP3K110.82671095
85CHEK10.82606193
86CLK10.82548884
87ADRBK20.81362202
88GRK60.80582209
89DAPK20.76710323
90CSNK1G30.75092093
91PLK30.74844175
92MAP2K40.74652797
93RPS6KC10.74048647
94RPS6KL10.74048647
95TSSK60.73509209
96BUB10.73349611
97TLK10.73143654
98PIM10.72636682
99MUSK0.70735676
100CSNK1A1L0.70598316
101KSR10.70439201
102MAP3K130.70176962
103AKT30.68937805
104YES10.68483351
105RPS6KA10.67474766
106MAP2K20.67438472
107STK390.67337089
108DYRK20.67169768
109CDK180.67119261
110CDK20.66891601
111BCR0.65678943
112PRKCE0.64794879
113MARK20.64509911
114WNK40.63439887
115MELK0.63351638
116ROCK20.62834742
117MET0.62706448
118BRSK10.62094436
119CAMK2D0.61769613
120STK40.61696657
121CDK150.61692605
122CHEK20.60858964
123PAK60.60354678
124EPHA30.60224901
125BLK0.59989844
126PTK60.59855337
127CDK140.59056313
128RPS6KA20.58745903
129AURKB0.58700809
130CDK11A0.58347147
131TXK0.57998461
132MAPK120.56988686
133BRAF0.56680393
134RPS6KA60.56285395
135LATS20.56193275
136SIK30.55579720
137PDK10.54731245
138SGK10.54367632
139PRKCQ0.53275193
140CDK10.53231456
141PRKCH0.52370909
142IRAK40.51870891
143ADRBK10.51376647
144CAMK10.50496760
145NEK60.50344032
146CAMK1G0.48774025
147CDK80.48229622
148CDK60.47809815
149STK380.47110876
150CDC42BPA0.44981331
151MAP3K140.44576858
152MAPK100.43941004
153CSNK1G10.43836198
154MAPK80.43586781
155CAMKK10.43326223
156PLK40.42519141
157SYK0.41599156
158GSK3B0.40030080
159MYLK0.39692555
160MAPK140.39392540
161PAK20.39379210
162BMPR1B0.39068868
163ICK0.38978727
164AKT10.38449081
165DYRK1B0.37870871
166STK110.37442024
167PRKD30.37329109
168RPS6KA50.37100680
169TIE10.37079426
170ERBB30.36865353
171SGK2230.36849705
172SGK4940.36849705
173PRKACA0.36562020
174MAPK10.35845382
175FGFR20.35735796
176CSNK1E0.35103220
177TTK0.34601774
178MAP2K60.33631287
179CAMK2G0.33199761
180TYRO30.32734037
181ALK0.32472833
182PTK20.32168553
183MAPK40.31929876
184FYN0.31879778

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.25229837
2DNA replication_Homo sapiens_hsa030302.89766738
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.57256810
4Glutamatergic synapse_Homo sapiens_hsa047242.39365704
5Long-term potentiation_Homo sapiens_hsa047202.36842812
6Circadian entrainment_Homo sapiens_hsa047132.35738045
7Morphine addiction_Homo sapiens_hsa050322.22500394
8Chronic myeloid leukemia_Homo sapiens_hsa052202.13212832
9Amphetamine addiction_Homo sapiens_hsa050312.13150808
10Synaptic vesicle cycle_Homo sapiens_hsa047212.11429110
11Acute myeloid leukemia_Homo sapiens_hsa052212.07672330
12Non-small cell lung cancer_Homo sapiens_hsa052232.04610668
13Base excision repair_Homo sapiens_hsa034102.00926436
14Taste transduction_Homo sapiens_hsa047421.94669941
15Oxidative phosphorylation_Homo sapiens_hsa001901.92224747
16GABAergic synapse_Homo sapiens_hsa047271.91141982
17Olfactory transduction_Homo sapiens_hsa047401.89092884
18Cell cycle_Homo sapiens_hsa041101.88774873
19Sulfur relay system_Homo sapiens_hsa041221.87519598
20Bladder cancer_Homo sapiens_hsa052191.86911150
21Serotonergic synapse_Homo sapiens_hsa047261.82754392
22Collecting duct acid secretion_Homo sapiens_hsa049661.81490566
23Long-term depression_Homo sapiens_hsa047301.76664850
24Salivary secretion_Homo sapiens_hsa049701.75478909
25Dopaminergic synapse_Homo sapiens_hsa047281.72998446
26Calcium signaling pathway_Homo sapiens_hsa040201.60853213
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.59827488
28Alzheimers disease_Homo sapiens_hsa050101.56525208
29RNA transport_Homo sapiens_hsa030131.56406407
30Central carbon metabolism in cancer_Homo sapiens_hsa052301.55367498
31Pancreatic cancer_Homo sapiens_hsa052121.52334656
32Notch signaling pathway_Homo sapiens_hsa043301.51004381
33Fructose and mannose metabolism_Homo sapiens_hsa000511.50513948
34Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.48762383
35Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.46687384
36Endometrial cancer_Homo sapiens_hsa052131.45947219
37Small cell lung cancer_Homo sapiens_hsa052221.45014788
38Phototransduction_Homo sapiens_hsa047441.43587484
39Biosynthesis of amino acids_Homo sapiens_hsa012301.43358087
40Viral carcinogenesis_Homo sapiens_hsa052031.39880231
41Thyroid cancer_Homo sapiens_hsa052161.39343548
42Axon guidance_Homo sapiens_hsa043601.38132166
43Parkinsons disease_Homo sapiens_hsa050121.35950089
44Cholinergic synapse_Homo sapiens_hsa047251.35159654
45Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.33685313
46Pyrimidine metabolism_Homo sapiens_hsa002401.33049248
47Renin secretion_Homo sapiens_hsa049241.29627876
48Huntingtons disease_Homo sapiens_hsa050161.29546908
49Oxytocin signaling pathway_Homo sapiens_hsa049211.28810218
50Gastric acid secretion_Homo sapiens_hsa049711.26509219
51MicroRNAs in cancer_Homo sapiens_hsa052061.26477155
52Colorectal cancer_Homo sapiens_hsa052101.26060137
53Cardiac muscle contraction_Homo sapiens_hsa042601.25389093
54mTOR signaling pathway_Homo sapiens_hsa041501.24896521
55Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.21977830
56GnRH signaling pathway_Homo sapiens_hsa049121.18270938
57Aldosterone synthesis and secretion_Homo sapiens_hsa049251.17750219
58Cocaine addiction_Homo sapiens_hsa050301.16600182
59Insulin secretion_Homo sapiens_hsa049111.16561910
60Lysine degradation_Homo sapiens_hsa003101.15776916
61HTLV-I infection_Homo sapiens_hsa051661.14071936
62Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.11516838
63Apoptosis_Homo sapiens_hsa042101.07580095
64Nucleotide excision repair_Homo sapiens_hsa034201.06190759
65Mismatch repair_Homo sapiens_hsa034301.05885322
66RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.05588192
67Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.05572213
68Hepatitis B_Homo sapiens_hsa051611.04648270
69Other glycan degradation_Homo sapiens_hsa005111.03186563
70Phosphatidylinositol signaling system_Homo sapiens_hsa040701.02828172
71B cell receptor signaling pathway_Homo sapiens_hsa046621.02579280
72cAMP signaling pathway_Homo sapiens_hsa040241.01191507
73Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.99950791
74Gap junction_Homo sapiens_hsa045400.99521026
75Vibrio cholerae infection_Homo sapiens_hsa051100.97657391
76Homologous recombination_Homo sapiens_hsa034400.97576755
77Epstein-Barr virus infection_Homo sapiens_hsa051690.95595772
78Melanogenesis_Homo sapiens_hsa049160.95426894
79Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.95153815
80Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.93152059
81RNA polymerase_Homo sapiens_hsa030200.91616755
82Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.90749902
83Adipocytokine signaling pathway_Homo sapiens_hsa049200.90063260
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.89003314
85Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.88091508
86ErbB signaling pathway_Homo sapiens_hsa040120.87934031
87Oocyte meiosis_Homo sapiens_hsa041140.87525907
88Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.87520041
89Renal cell carcinoma_Homo sapiens_hsa052110.87163406
90Prostate cancer_Homo sapiens_hsa052150.84535344
91Glioma_Homo sapiens_hsa052140.84169130
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.83717187
93FoxO signaling pathway_Homo sapiens_hsa040680.83665625
94Systemic lupus erythematosus_Homo sapiens_hsa053220.81814720
95Cyanoamino acid metabolism_Homo sapiens_hsa004600.81705750
96Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.81361785
97AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.80246022
98Herpes simplex infection_Homo sapiens_hsa051680.79986869
99Vascular smooth muscle contraction_Homo sapiens_hsa042700.78782267
100Viral myocarditis_Homo sapiens_hsa054160.78769548
101Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.78746570
102Osteoclast differentiation_Homo sapiens_hsa043800.77921896
103Insulin signaling pathway_Homo sapiens_hsa049100.77729757
104Estrogen signaling pathway_Homo sapiens_hsa049150.77315061
105cGMP-PKG signaling pathway_Homo sapiens_hsa040220.76014047
106Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.73402115
107Dorso-ventral axis formation_Homo sapiens_hsa043200.73398259
108Hepatitis C_Homo sapiens_hsa051600.73371857
109Wnt signaling pathway_Homo sapiens_hsa043100.73210143
110Ribosome_Homo sapiens_hsa030100.73073228
111TNF signaling pathway_Homo sapiens_hsa046680.71674792
112MAPK signaling pathway_Homo sapiens_hsa040100.71361972
113Ras signaling pathway_Homo sapiens_hsa040140.71344232
114Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.71011087
115Non-homologous end-joining_Homo sapiens_hsa034500.70989357
116Choline metabolism in cancer_Homo sapiens_hsa052310.70835434
117Hippo signaling pathway_Homo sapiens_hsa043900.69492206
118Pentose phosphate pathway_Homo sapiens_hsa000300.66694205
119Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66082530
120Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.65801011
121Alcoholism_Homo sapiens_hsa050340.65704939
122Rheumatoid arthritis_Homo sapiens_hsa053230.64906318
123Phospholipase D signaling pathway_Homo sapiens_hsa040720.63983959
124Vitamin B6 metabolism_Homo sapiens_hsa007500.63238396
125Regulation of autophagy_Homo sapiens_hsa041400.62891281
126Influenza A_Homo sapiens_hsa051640.62737454
127Measles_Homo sapiens_hsa051620.62307615
128Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62132004
129NF-kappa B signaling pathway_Homo sapiens_hsa040640.61651272
130Proteoglycans in cancer_Homo sapiens_hsa052050.61440478
131Toll-like receptor signaling pathway_Homo sapiens_hsa046200.59438908
132Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58453632
133Pathways in cancer_Homo sapiens_hsa052000.58312055
134Fanconi anemia pathway_Homo sapiens_hsa034600.58268979
135Adherens junction_Homo sapiens_hsa045200.57381458
136Prolactin signaling pathway_Homo sapiens_hsa049170.57060996
137Purine metabolism_Homo sapiens_hsa002300.56341471
138Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.55662154
139Leukocyte transendothelial migration_Homo sapiens_hsa046700.54697796
140Autoimmune thyroid disease_Homo sapiens_hsa053200.54672615
141AMPK signaling pathway_Homo sapiens_hsa041520.54547356
142Toxoplasmosis_Homo sapiens_hsa051450.54392451
143Spliceosome_Homo sapiens_hsa030400.53918093
144T cell receptor signaling pathway_Homo sapiens_hsa046600.52958015
145Basal transcription factors_Homo sapiens_hsa030220.52412437
146Insulin resistance_Homo sapiens_hsa049310.51884136
147Legionellosis_Homo sapiens_hsa051340.51857136
148Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.51250856
149Sphingolipid signaling pathway_Homo sapiens_hsa040710.51233128
150mRNA surveillance pathway_Homo sapiens_hsa030150.50646121
151HIF-1 signaling pathway_Homo sapiens_hsa040660.49884414
152SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49496772
153Pancreatic secretion_Homo sapiens_hsa049720.49214770
154Dilated cardiomyopathy_Homo sapiens_hsa054140.49123370
155VEGF signaling pathway_Homo sapiens_hsa043700.49097355
156Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.48401965
157African trypanosomiasis_Homo sapiens_hsa051430.48033225
158Inositol phosphate metabolism_Homo sapiens_hsa005620.48013078
159Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.47967814
160Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.47867213
161Hedgehog signaling pathway_Homo sapiens_hsa043400.47830305
162Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.47513003
163Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.46654740
164Rap1 signaling pathway_Homo sapiens_hsa040150.46409476
165Proteasome_Homo sapiens_hsa030500.45158157
166Phagosome_Homo sapiens_hsa041450.44049502
167Sphingolipid metabolism_Homo sapiens_hsa006000.43837048
168Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.43394672
169Chemokine signaling pathway_Homo sapiens_hsa040620.42491526
170Type II diabetes mellitus_Homo sapiens_hsa049300.38647443
171Basal cell carcinoma_Homo sapiens_hsa052170.37808338
172Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37440713
173Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37113280
174Primary immunodeficiency_Homo sapiens_hsa053400.36217757
175Ether lipid metabolism_Homo sapiens_hsa005650.35916061
176Neurotrophin signaling pathway_Homo sapiens_hsa047220.35798732

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