BRCA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)5.70149394
2nuclear pore complex assembly (GO:0051292)5.18142065
3meiotic chromosome segregation (GO:0045132)5.14664974
4metaphase plate congression (GO:0051310)5.09577882
5kinetochore organization (GO:0051383)5.08671331
6protein K6-linked ubiquitination (GO:0085020)4.97916241
7microtubule depolymerization (GO:0007019)4.90085572
8nuclear pore organization (GO:0006999)4.88775753
9kinetochore assembly (GO:0051382)4.87254234
10protein localization to kinetochore (GO:0034501)4.67581906
11DNA unwinding involved in DNA replication (GO:0006268)4.57648517
12nucleotide-excision repair, DNA gap filling (GO:0006297)4.49031472
13mitotic chromosome condensation (GO:0007076)4.39408632
14protein localization to chromosome, centromeric region (GO:0071459)4.35408329
15DNA replication checkpoint (GO:0000076)4.32783594
16chromatin remodeling at centromere (GO:0031055)4.29771764
17CENP-A containing nucleosome assembly (GO:0034080)4.26680692
18establishment of chromosome localization (GO:0051303)4.25693076
19telomere maintenance via telomere lengthening (GO:0010833)4.17336318
20mitotic sister chromatid segregation (GO:0000070)4.16329036
21mitotic sister chromatid cohesion (GO:0007064)4.16321282
22DNA double-strand break processing (GO:0000729)4.12283738
23pore complex assembly (GO:0046931)4.07102856
24DNA ligation (GO:0006266)4.04210658
25DNA replication-independent nucleosome assembly (GO:0006336)4.00650319
26DNA replication-independent nucleosome organization (GO:0034724)4.00650319
27mitotic G2/M transition checkpoint (GO:0044818)4.00621656
28double-strand break repair via nonhomologous end joining (GO:0006303)3.98427902
29non-recombinational repair (GO:0000726)3.98427902
30histone exchange (GO:0043486)3.93448992
31regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.93423310
32DNA replication initiation (GO:0006270)3.93378309
33attachment of spindle microtubules to kinetochore (GO:0008608)3.92154874
34monoubiquitinated protein deubiquitination (GO:0035520)3.92017106
35regulation of spindle organization (GO:0090224)3.89055549
36somatic diversification of immune receptors via somatic mutation (GO:0002566)3.80115084
37somatic hypermutation of immunoglobulin genes (GO:0016446)3.80115084
38sister chromatid segregation (GO:0000819)3.80036905
39regulation of helicase activity (GO:0051095)3.78572050
40DNA topological change (GO:0006265)3.77472730
41regulation of double-strand break repair via homologous recombination (GO:0010569)3.76669963
42regulation of meiosis I (GO:0060631)3.75762030
43DNA synthesis involved in DNA repair (GO:0000731)3.74114898
44regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.71223028
45sister chromatid cohesion (GO:0007062)3.67713247
46regulation of nuclear cell cycle DNA replication (GO:0033262)3.67218880
47piRNA metabolic process (GO:0034587)3.66098689
48postreplication repair (GO:0006301)3.65941300
49positive regulation of mitotic sister chromatid separation (GO:1901970)3.65631469
50positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.65631469
51positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.65631469
52translesion synthesis (GO:0019985)3.63680775
53spindle checkpoint (GO:0031577)3.62932814
54reciprocal meiotic recombination (GO:0007131)3.60725252
55reciprocal DNA recombination (GO:0035825)3.60725252
56telomere maintenance (GO:0000723)3.60649374
57protein localization to chromosome (GO:0034502)3.59879819
58telomere organization (GO:0032200)3.57932621
59replication fork processing (GO:0031297)3.57695621
60chromosome condensation (GO:0030261)3.56862947
61regulation of centriole replication (GO:0046599)3.55642561
62chromosome segregation (GO:0007059)3.53192750
63positive regulation of chromosome segregation (GO:0051984)3.51035671
64establishment of integrated proviral latency (GO:0075713)3.48504770
65regulation of centrosome duplication (GO:0010824)3.48165364
66regulation of mitotic spindle organization (GO:0060236)3.45016956
67mitotic nuclear envelope disassembly (GO:0007077)3.44571121
68mismatch repair (GO:0006298)3.42937073
69regulation of chromosome segregation (GO:0051983)3.42258468
70regulation of histone H3-K9 methylation (GO:0051570)3.41938995
71* maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.41681267
72regulation of mitotic metaphase/anaphase transition (GO:0030071)3.39051267
73regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.36531640
74synapsis (GO:0007129)3.35285141
75DNA replication-dependent nucleosome organization (GO:0034723)3.35146409
76DNA replication-dependent nucleosome assembly (GO:0006335)3.35146409
77DNA duplex unwinding (GO:0032508)3.34051693
78chromatin assembly or disassembly (GO:0006333)3.32562918
79DNA strand renaturation (GO:0000733)3.31648172
80negative regulation of DNA recombination (GO:0045910)3.31564701
81* recombinational repair (GO:0000725)3.31166172
82DNA geometric change (GO:0032392)3.30880899
83purine nucleobase biosynthetic process (GO:0009113)3.30833332
84intra-S DNA damage checkpoint (GO:0031573)3.30568395
85* double-strand break repair via homologous recombination (GO:0000724)3.30302989
86negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.29511491
87mitotic G2 DNA damage checkpoint (GO:0007095)3.27930962
88spindle assembly checkpoint (GO:0071173)3.26540172
89regulation of mitotic sister chromatid separation (GO:0010965)3.25345432
90regulation of mitotic sister chromatid segregation (GO:0033047)3.25345432
91regulation of sister chromatid segregation (GO:0033045)3.25345432
92* negative regulation of DNA-dependent DNA replication (GO:2000104)3.25263129
93regulation of telomere maintenance via telomerase (GO:0032210)3.24826057
94negative regulation of chromosome segregation (GO:0051985)3.24740690
95regulation of centrosome cycle (GO:0046605)3.23278695
96telomere maintenance via recombination (GO:0000722)3.22764484
97mitotic spindle checkpoint (GO:0071174)3.21341974
98regulation of double-strand break repair (GO:2000779)3.20378764
99negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.19738073
100negative regulation of sister chromatid segregation (GO:0033046)3.19738073
101negative regulation of mitotic sister chromatid separation (GO:2000816)3.19738073
102negative regulation of mitotic sister chromatid segregation (GO:0033048)3.19738073
103mitotic recombination (GO:0006312)3.18554734
104resolution of meiotic recombination intermediates (GO:0000712)3.17727373
105negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.17045415
106regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.14179355
107regulation of mitotic spindle checkpoint (GO:1903504)3.14179355
108nuclear envelope disassembly (GO:0051081)3.13358359
109membrane disassembly (GO:0030397)3.13358359
110mitotic spindle assembly checkpoint (GO:0007094)3.13085716
111DNA methylation involved in gamete generation (GO:0043046)3.12655672
112regulation of RNA export from nucleus (GO:0046831)3.11529085
113regulation of sister chromatid cohesion (GO:0007063)3.11402360
114ATP-dependent chromatin remodeling (GO:0043044)3.08736113
115male meiosis (GO:0007140)3.06390488
116telomere maintenance via semi-conservative replication (GO:0032201)3.05241785
117regulation of DNA endoreduplication (GO:0032875)3.05076374
118DNA strand elongation involved in DNA replication (GO:0006271)3.04905652
119histone H3-K9 methylation (GO:0051567)3.03010168
120positive regulation of DNA-dependent DNA replication (GO:2000105)2.97940028
121maturation of 5.8S rRNA (GO:0000460)2.97747079
122DNA strand elongation (GO:0022616)2.96846384
123* meiotic cell cycle process (GO:1903046)2.96218404
124centriole replication (GO:0007099)2.95938850
125chromosome organization (GO:0051276)2.94655672
126regulation of DNA damage checkpoint (GO:2000001)2.93824273

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.00583589
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.66616541
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.90210205
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.46600073
5MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.01885594
6* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.95964290
7TP63_19390658_ChIP-ChIP_HaCaT_Human2.89909663
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.80743983
9MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.73803667
10* E2F1_21310950_ChIP-Seq_MCF-7_Human2.33996299
11AR_21909140_ChIP-Seq_LNCAP_Human2.20927131
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.15198165
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.12990235
14BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.07717797
15MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.07164951
16PCGF2_27294783_Chip-Seq_ESCs_Mouse2.00555966
17E2F7_22180533_ChIP-Seq_HELA_Human11.5758268
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.71011753
19KAP1_22055183_ChIP-Seq_ESCs_Mouse1.70134440
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.65468126
21* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.65376908
22* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.61890819
23* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.57655751
24NFE2_27457419_Chip-Seq_LIVER_Mouse1.54147062
25SUZ12_27294783_Chip-Seq_NPCs_Mouse1.52669349
26PCGF2_27294783_Chip-Seq_NPCs_Mouse1.51611794
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.49686350
28* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.43390295
29YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43041541
30NANOG_18555785_ChIP-Seq_MESCs_Mouse1.41095619
31DCP1A_22483619_ChIP-Seq_HELA_Human1.40132964
32EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.37073769
33CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.33924660
34EST1_17652178_ChIP-ChIP_JURKAT_Human1.33735467
35CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.32037333
36E2F1_18555785_ChIP-Seq_MESCs_Mouse1.30646956
37VDR_23849224_ChIP-Seq_CD4+_Human1.28726511
38FUS_26573619_Chip-Seq_HEK293_Human1.28045158
39EGR1_19374776_ChIP-ChIP_THP-1_Human1.27795481
40FOXP3_21729870_ChIP-Seq_TREG_Human1.27688023
41HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.24032158
42THAP11_20581084_ChIP-Seq_MESCs_Mouse1.23422116
43EWS_26573619_Chip-Seq_HEK293_Human1.21349678
44POU5F1_16153702_ChIP-ChIP_HESCs_Human1.21138202
45RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19261060
46* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.19044436
47SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.18289613
48POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.17752372
49RBPJ_22232070_ChIP-Seq_NCS_Mouse1.17423815
50NOTCH1_21737748_ChIP-Seq_TLL_Human1.15626318
51EZH2_27294783_Chip-Seq_NPCs_Mouse1.14325716
52PADI4_21655091_ChIP-ChIP_MCF-7_Human1.13473181
53GABP_19822575_ChIP-Seq_HepG2_Human1.13468397
54MYC_18940864_ChIP-ChIP_HL60_Human1.10799081
55SOX2_18555785_ChIP-Seq_MESCs_Mouse1.10514945
56FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.10489908
57PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10471493
58ELK1_19687146_ChIP-ChIP_HELA_Human1.09969312
59POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.06040906
60SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.05788123
61NANOG_16153702_ChIP-ChIP_HESCs_Human1.03959044
62NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.03161766
63ZNF274_21170338_ChIP-Seq_K562_Hela1.02312053
64SOX2_16153702_ChIP-ChIP_HESCs_Human1.01493830
65* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.01479176
66* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.00072351
67ETS1_20019798_ChIP-Seq_JURKAT_Human0.99203669
68HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.97624698
69VDR_22108803_ChIP-Seq_LS180_Human0.96614449
70GABP_17652178_ChIP-ChIP_JURKAT_Human0.96342381
71IRF1_19129219_ChIP-ChIP_H3396_Human0.95286896
72TTF2_22483619_ChIP-Seq_HELA_Human0.95055047
73* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.94422097
74SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.93236062
75IGF1R_20145208_ChIP-Seq_DFB_Human0.92944848
76KDM5A_27292631_Chip-Seq_BREAST_Human0.92902236
77HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.92447905
78TCF3_18692474_ChIP-Seq_MESCs_Mouse0.92369595
79GATA1_26923725_Chip-Seq_HPCs_Mouse0.92342733
80NANOG_18555785_Chip-Seq_ESCs_Mouse0.91816298
81POU3F2_20337985_ChIP-ChIP_501MEL_Human0.91726250
82ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.90660736
83STAT3_18555785_Chip-Seq_ESCs_Mouse0.90078733
84SRF_21415370_ChIP-Seq_HL-1_Mouse0.89314029
85XRN2_22483619_ChIP-Seq_HELA_Human0.89234379
86HOXB4_20404135_ChIP-ChIP_EML_Mouse0.89204476
87ESR1_15608294_ChIP-ChIP_MCF-7_Human0.88005451
88TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.86724720
89OCT4_18555785_Chip-Seq_ESCs_Mouse0.85634356
90NMYC_18555785_Chip-Seq_ESCs_Mouse0.85602390
91ERG_20887958_ChIP-Seq_HPC-7_Mouse0.85597038
92EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.85146510
93* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.85010351
94E2F1_18555785_Chip-Seq_ESCs_Mouse0.84729601
95* CREB1_15753290_ChIP-ChIP_HEK293T_Human0.84072124
96SUZ12_18555785_Chip-Seq_ESCs_Mouse0.83720901
97* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.83627682
98KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.83314267
99KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.83314267
100KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.83314267
101CIITA_25753668_ChIP-Seq_RAJI_Human0.82768231
102CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.82710430
103EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.81968230
104NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.81429216
105SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.80701157
106ZFX_18555785_Chip-Seq_ESCs_Mouse0.80156977
107GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79641225
108FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.79582712
109RNF2_27304074_Chip-Seq_NSC_Mouse0.78657570
110ZFP57_27257070_Chip-Seq_ESCs_Mouse0.77803986
111SMAD_19615063_ChIP-ChIP_OVARY_Human0.76462598
112RUNX1_27457419_Chip-Seq_LIVER_Mouse0.76337825
113KLF4_18555785_Chip-Seq_ESCs_Mouse0.76323007
114CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.76263439
115PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.75815809
116TAF15_26573619_Chip-Seq_HEK293_Human0.75641362
117SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.75362642
118CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.75136004
119SOX17_20123909_ChIP-Seq_XEN_Mouse0.74575997
120CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.72311824
121ELF1_17652178_ChIP-ChIP_JURKAT_Human0.70606547
122ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.67827581
123P300_19829295_ChIP-Seq_ESCs_Human0.64683633
124RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.63335657
125FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.60938064
126CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.58254673
127PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.58241411
128FOXM1_26456572_ChIP-Seq_MCF-7_Human0.57996379
129HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.55707419
130* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.54815724

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.95127468
2* MP0010094_abnormal_chromosome_stability4.52001407
3MP0003693_abnormal_embryo_hatching4.47443937
4* MP0003111_abnormal_nucleus_morphology4.25947515
5MP0008877_abnormal_DNA_methylation4.03826977
6* MP0003077_abnormal_cell_cycle3.53981609
7* MP0008058_abnormal_DNA_repair3.52222263
8MP0006292_abnormal_olfactory_placode2.93924007
9MP0004957_abnormal_blastocyst_morpholog2.88711320
10MP0003787_abnormal_imprinting2.54487185
11MP0002102_abnormal_ear_morphology2.46998228
12MP0003718_maternal_effect2.29235249
13MP0003121_genomic_imprinting2.17352770
14MP0003786_premature_aging2.05519622
15MP0008932_abnormal_embryonic_tissue2.02162182
16* MP0008007_abnormal_cellular_replicative2.00270719
17* MP0002210_abnormal_sex_determination1.98018303
18MP0003123_paternal_imprinting1.94099125
19MP0003136_yellow_coat_color1.87918912
20MP0005451_abnormal_body_composition1.85369624
21* MP0001929_abnormal_gametogenesis1.78146941
22* MP0000350_abnormal_cell_proliferation1.75353326
23MP0001188_hyperpigmentation1.72189347
24MP0000569_abnormal_digit_pigmentation1.70864170
25MP0000566_synostosis1.70650245
26MP0008995_early_reproductive_senescence1.68471974
27MP0000490_abnormal_crypts_of1.61666944
28MP0003937_abnormal_limbs/digits/tail_de1.59878870
29MP0001730_embryonic_growth_arrest1.56020059
30* MP0001145_abnormal_male_reproductive1.55691461
31* MP0000653_abnormal_sex_gland1.51329127
32MP0003890_abnormal_embryonic-extraembry1.47203893
33* MP0001672_abnormal_embryogenesis/_devel1.46057432
34* MP0005380_embryogenesis_phenotype1.46057432
35* MP0002085_abnormal_embryonic_tissue1.41477304
36MP0004808_abnormal_hematopoietic_stem1.36669598
37* MP0001119_abnormal_female_reproductive1.35339219
38* MP0010307_abnormal_tumor_latency1.34306344
39MP0003941_abnormal_skin_development1.33759423
40* MP0002084_abnormal_developmental_patter1.29737091
41MP0000383_abnormal_hair_follicle1.27691128
42MP0001697_abnormal_embryo_size1.25821422
43MP0002653_abnormal_ependyma_morphology1.23924997
44* MP0003698_abnormal_male_reproductive1.22489165
45MP0008789_abnormal_olfactory_epithelium1.18889870
46MP0001293_anophthalmia1.12365598
47* MP0003984_embryonic_growth_retardation1.10935541
48* MP0000313_abnormal_cell_death1.07132157
49* MP0002088_abnormal_embryonic_growth/wei1.06772058
50* MP0002086_abnormal_extraembryonic_tissu1.05710039
51MP0005076_abnormal_cell_differentiation1.03525995
52MP0003315_abnormal_perineum_morphology1.03024038
53MP0002277_abnormal_respiratory_mucosa1.02675757
54MP0006072_abnormal_retinal_apoptosis1.02362758
55MP0005397_hematopoietic_system_phenotyp1.00417646
56MP0001545_abnormal_hematopoietic_system1.00417646
57MP0008260_abnormal_autophagy0.99656349
58MP0000015_abnormal_ear_pigmentation0.98907778
59* MP0002396_abnormal_hematopoietic_system0.98875650
60MP0005075_abnormal_melanosome_morpholog0.98475137
61* MP0003699_abnormal_female_reproductive0.98312853
62* MP0002080_prenatal_lethality0.97305368
63MP0000432_abnormal_head_morphology0.96963985
64* MP0002019_abnormal_tumor_incidence0.95556524
65MP0002160_abnormal_reproductive_system0.93891527
66MP0002249_abnormal_larynx_morphology0.91782931
67MP0005174_abnormal_tail_pigmentation0.90111478
68* MP0002161_abnormal_fertility/fecundity0.89978247
69MP0005394_taste/olfaction_phenotype0.89141949
70MP0005499_abnormal_olfactory_system0.89141949
71MP0001286_abnormal_eye_development0.88420474
72* MP0009672_abnormal_birth_weight0.88309016
73MP0003938_abnormal_ear_development0.87831991
74MP0009697_abnormal_copulation0.87508427
75MP0005408_hypopigmentation0.86287635
76MP0002938_white_spotting0.84803478
77* MP0004197_abnormal_fetal_growth/weight/0.84697317
78MP0005395_other_phenotype0.84675409
79MP0000428_abnormal_craniofacial_morphol0.83842604
80MP0003567_abnormal_fetal_cardiomyocyte0.83367878
81MP0002163_abnormal_gland_morphology0.82209812
82MP0003755_abnormal_palate_morphology0.82040983
83MP0002234_abnormal_pharynx_morphology0.81971904
84MP0003935_abnormal_craniofacial_develop0.81738761
85MP0002095_abnormal_skin_pigmentation0.81673451
86MP0006035_abnormal_mitochondrial_morpho0.81282960
87MP0000358_abnormal_cell_content/0.81204726
88MP0000427_abnormal_hair_cycle0.81178698
89MP0000372_irregular_coat_pigmentation0.79204007
90MP0005389_reproductive_system_phenotype0.78589009
91* MP0002111_abnormal_tail_morphology0.78109147
92MP0000647_abnormal_sebaceous_gland0.77494054
93MP0003806_abnormal_nucleotide_metabolis0.76023030
94MP0002751_abnormal_autonomic_nervous0.74921795
95MP0002132_abnormal_respiratory_system0.71639091
96MP0003943_abnormal_hepatobiliary_system0.71443085
97MP0000579_abnormal_nail_morphology0.69552929
98MP0003763_abnormal_thymus_physiology0.69180605
99* MP0003861_abnormal_nervous_system0.69012642
100MP0002075_abnormal_coat/hair_pigmentati0.68461865
101MP0004264_abnormal_extraembryonic_tissu0.67973664
102MP0001186_pigmentation_phenotype0.67719596
103MP0003119_abnormal_digestive_system0.67531660
104MP0002092_abnormal_eye_morphology0.66739042
105MP0004381_abnormal_hair_follicle0.66544327
106MP0002697_abnormal_eye_size0.66173673
107MP0010678_abnormal_skin_adnexa0.66072986
108MP0001324_abnormal_eye_pigmentation0.65895971
109MP0005391_vision/eye_phenotype0.65289885
110MP0010352_gastrointestinal_tract_polyps0.65139099
111MP0002009_preneoplasia0.64745486
112MP0002233_abnormal_nose_morphology0.64004913
113* MP0000703_abnormal_thymus_morphology0.63175735
114MP0000462_abnormal_digestive_system0.62544829
115* MP0009703_decreased_birth_body0.62044036
116MP0010030_abnormal_orbit_morphology0.61655258
117* MP0005384_cellular_phenotype0.61521458
118MP0001346_abnormal_lacrimal_gland0.61267620
119MP0005410_abnormal_fertilization0.60937675
120MP0003950_abnormal_plasma_membrane0.60484118
121MP0002177_abnormal_outer_ear0.60021495
122MP0001529_abnormal_vocalization0.56263188
123MP0002006_tumorigenesis0.54339779

Predicted human phenotypes

RankGene SetZ-score
1* Chromsome breakage (HP:0040012)5.79872138
2* Chromosomal breakage induced by crosslinking agents (HP:0003221)5.71821502
3Birth length less than 3rd percentile (HP:0003561)4.41013787
4* Abnormality of chromosome stability (HP:0003220)4.04163310
5Ectopic kidney (HP:0000086)3.93355052
6* Aplasia/Hypoplasia of the uvula (HP:0010293)3.65192031
7Abnormality of the labia minora (HP:0012880)3.62582695
8* Meckel diverticulum (HP:0002245)3.62263899
9* Abnormality of the preputium (HP:0100587)3.59811574
10Colon cancer (HP:0003003)3.54094425
11Impulsivity (HP:0100710)3.53730438
12* Abnormality of the ileum (HP:0001549)3.43777335
13Patellar aplasia (HP:0006443)3.24439436
14Duplicated collecting system (HP:0000081)3.24394504
15Supernumerary spleens (HP:0009799)3.07101852
16Volvulus (HP:0002580)2.97469123
17Abnormality of the renal collecting system (HP:0004742)2.96967697
18Aplasia/Hypoplasia of the patella (HP:0006498)2.96957936
19Facial hemangioma (HP:0000329)2.96461365
20Breast hypoplasia (HP:0003187)2.95805802
21Abnormality of DNA repair (HP:0003254)2.89557238
22Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.87999320
23Absent radius (HP:0003974)2.83010168
24Medulloblastoma (HP:0002885)2.80266480
25* Duodenal stenosis (HP:0100867)2.76022181
26* Small intestinal stenosis (HP:0012848)2.76022181
27* Myelodysplasia (HP:0002863)2.68347653
28Aplasia involving forearm bones (HP:0009822)2.66264434
29Absent forearm bone (HP:0003953)2.66264434
30* Clubbing of toes (HP:0100760)2.65283320
31Abnormality of the fingertips (HP:0001211)2.65264457
32* Abnormality of the carotid arteries (HP:0005344)2.64350174
33Papillary thyroid carcinoma (HP:0002895)2.62009160
34* Sloping forehead (HP:0000340)2.53951408
35Capillary hemangiomas (HP:0005306)2.52997386
36Abnormal spermatogenesis (HP:0008669)2.44152413
37Aplasia/Hypoplasia of the sacrum (HP:0008517)2.36113456
38Oligodactyly (hands) (HP:0001180)2.34593636
39Prominent nose (HP:0000448)2.30299127
40Absent thumb (HP:0009777)2.28529563
41Ependymoma (HP:0002888)2.28103159
42Azoospermia (HP:0000027)2.27581802
43* Short thumb (HP:0009778)2.25971401
44* Bone marrow hypocellularity (HP:0005528)2.23235823
45* Abnormality of the duodenum (HP:0002246)2.21703434
46Neoplasm of the oral cavity (HP:0100649)2.20544383
47Aplasia/Hypoplasia of the earlobes (HP:0009906)2.20189938
48Neoplasm of the colon (HP:0100273)2.18938456
49Oligodactyly (HP:0012165)2.16112916
50Cortical dysplasia (HP:0002539)2.12722641
51Shawl scrotum (HP:0000049)2.07173625
52Lip pit (HP:0100267)2.06862912
53Anal stenosis (HP:0002025)2.06787281
54Horseshoe kidney (HP:0000085)2.04943456
55Abnormal lung lobation (HP:0002101)2.03434415
56Multiple enchondromatosis (HP:0005701)2.01983143
57Long eyelashes (HP:0000527)2.00762793
58* Choanal atresia (HP:0000453)2.00094671
59Abnormality of cochlea (HP:0000375)1.99533764
60* Triphalangeal thumb (HP:0001199)1.99470143
61Breast aplasia (HP:0100783)1.96331307
62Rhabdomyosarcoma (HP:0002859)1.95673263
63Pancreatic fibrosis (HP:0100732)1.94034684
64* Tracheoesophageal fistula (HP:0002575)1.92915349
65Aplasia/Hypoplasia of the sternum (HP:0006714)1.92649824
66Reticulocytopenia (HP:0001896)1.92372348
67Glioma (HP:0009733)1.91830306
68Neoplasm of the adrenal cortex (HP:0100641)1.91790297
69Squamous cell carcinoma (HP:0002860)1.91395566
70B lymphocytopenia (HP:0010976)1.90577943
71Astrocytoma (HP:0009592)1.89695625
72Abnormality of the astrocytes (HP:0100707)1.89695625
73Clitoromegaly (HP:0000057)1.89556144
74Small hand (HP:0200055)1.88685756
75Abnormality of the pons (HP:0007361)1.88065608
76Neoplasm of striated muscle (HP:0009728)1.87990487
77* Nephroblastoma (Wilms tumor) (HP:0002667)1.86668472
78Agnosia (HP:0010524)1.86020017
79Hypoplasia of the pons (HP:0012110)1.85327858
80Rib fusion (HP:0000902)1.85016406
81Abnormality of chromosome segregation (HP:0002916)1.82569007
82Increased nuchal translucency (HP:0010880)1.81600123
83Aplasia/Hypoplasia of the breasts (HP:0010311)1.81518687
84Abnormal number of incisors (HP:0011064)1.80826599
85* Embryonal neoplasm (HP:0002898)1.80304548
86Microtia (HP:0008551)1.79614945
87Selective tooth agenesis (HP:0001592)1.76151738
88Bifid tongue (HP:0010297)1.75806425
89Adrenal hypoplasia (HP:0000835)1.74685572
90* Cafe-au-lait spot (HP:0000957)1.74516108
91Abnormality of the septum pellucidum (HP:0007375)1.74172249
92Combined immunodeficiency (HP:0005387)1.73778895
93Intestinal atresia (HP:0011100)1.73080196
94Aplastic anemia (HP:0001915)1.72838949
95* Embryonal renal neoplasm (HP:0011794)1.71712454
96Abnormal respiratory motile cilium physiology (HP:0012261)1.71708585
97Duplication of thumb phalanx (HP:0009942)1.71616868
98Biliary tract neoplasm (HP:0100574)1.70881422
99Ovarian neoplasm (HP:0100615)1.69362138
100High pitched voice (HP:0001620)1.68112763
101Dandy-Walker malformation (HP:0001305)1.67364095
102Pancreatic cysts (HP:0001737)1.66960969
103Breast carcinoma (HP:0003002)1.66879342
104Pancytopenia (HP:0001876)1.66718392
105Septo-optic dysplasia (HP:0100842)1.66437634
106Abnormal umbilical cord blood vessels (HP:0011403)1.66022494
107Single umbilical artery (HP:0001195)1.66022494
108Abnormality of the fetal cardiovascular system (HP:0010948)1.66022494
109Abnormality of B cell number (HP:0010975)1.66016851
110Premature graying of hair (HP:0002216)1.65144513
111Deep philtrum (HP:0002002)1.65093296
112IgM deficiency (HP:0002850)1.64249905
113Tubulointerstitial nephritis (HP:0001970)1.63844914
114Microglossia (HP:0000171)1.63577294
115Facial cleft (HP:0002006)1.63120649
116Overlapping toe (HP:0001845)1.62931837
117Fair hair (HP:0002286)1.62068157
118Abnormality of the clitoris (HP:0000056)1.61954778
119Median cleft lip (HP:0000161)1.61912718
120Preaxial hand polydactyly (HP:0001177)1.60803949
121Abdominal situs inversus (HP:0003363)1.60518733
122Abnormality of abdominal situs (HP:0011620)1.60518733
123Sandal gap (HP:0001852)1.60396165
124Nephronophthisis (HP:0000090)1.59810954
125Abnormality of lateral ventricle (HP:0030047)1.59231148
126Abnormality of the incisor (HP:0000676)1.59003402
127* Acute myeloid leukemia (HP:0004808)1.58753599
128Carpal bone hypoplasia (HP:0001498)1.58608822
129* Astigmatism (HP:0000483)1.58582441
130Cleft eyelid (HP:0000625)1.58433692
131Male pseudohermaphroditism (HP:0000037)1.57922996
132Abnormal auditory evoked potentials (HP:0006958)1.56731006
133Abnormality of the phalanges of the hallux (HP:0010057)1.56725025
13411 pairs of ribs (HP:0000878)1.56455386
135Truncal obesity (HP:0001956)1.54472410
136Amaurosis fugax (HP:0100576)1.54187804
137* Arteriovenous malformation (HP:0100026)1.54076664
138Proximal placement of thumb (HP:0009623)1.53868395

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.75533697
2CDK123.71840716
3LATS13.15585035
4SRPK13.07399578
5PLK43.03687851
6NEK22.99237949
7TTK2.97802523
8STK38L2.96900213
9WEE12.94730298
10PBK2.30022154
11ZAK2.27170149
12MKNK22.24019393
13CHEK22.19111924
14BRD42.18254061
15BRSK22.07126451
16TAF12.05368099
17* PLK12.03800048
18ATR1.92465106
19LATS21.90015126
20BUB11.85916968
21STK31.85836033
22AURKB1.81842598
23VRK21.78163119
24EIF2AK21.76862388
25MKNK11.75053473
26DYRK31.71268692
27CDK71.70668251
28PLK31.58824483
29VRK11.56751367
30MST41.55202728
31CHEK11.54719363
32ATM1.43702095
33ACVR1B1.43081520
34TRIM281.34581610
35MUSK1.34389017
36STK41.27146691
37CDK41.26882782
38TNIK1.22902809
39EIF2AK11.21854344
40NUAK11.19309424
41AKT31.18498021
42TLK11.16488308
43ERBB41.14507647
44MAP3K61.12845466
45CDK31.09869346
46CDK91.09573941
47CAMK1D0.99838652
48BRSK10.98109632
49MELK0.97936544
50WNK30.96721282
51CDK20.96501782
52CDK80.94933486
53FRK0.92408123
54CDK10.90134601
55TAOK30.88504077
56SCYL20.87219920
57AURKA0.85635709
58PNCK0.84962165
59GRK10.81874927
60IRAK30.81513249
61PLK20.77121434
62NEK60.76457447
63STK160.75796121
64PIM10.75362176
65PASK0.72850384
66EIF2AK30.70763103
67DYRK20.68628479
68CCNB10.68257484
69NLK0.67577074
70YES10.66996025
71CAMK1G0.65260421
72EPHA20.65057053
73TGFBR10.64460139
74RPS6KB20.63645057
75MAP3K100.63110976
76MAP3K80.63091467
77STK390.63040301
78ERBB30.61878652
79MAPK140.56064411
80STK240.55301279
81BRAF0.53108578
82RPS6KA50.52197466
83TXK0.51981985
84MARK30.51595402
85CSNK1D0.51336476
86NME10.50505993
87SGK20.48970015
88RPS6KA40.48639751
89PRKDC0.47471129
90TEC0.45589451
91GSK3B0.45485836
92MAPK100.44560509
93EEF2K0.44452615
94AKT10.44296651
95ALK0.43859623
96CDK60.43293105
97CSNK1G10.43179238
98STK100.41719517
99CASK0.41552993
100MTOR0.41528111
101CSNK2A10.40390831
102CHUK0.40374073
103OXSR10.40035230
104CSNK2A20.39881050
105NEK10.39564961
106TSSK60.39388440
107AKT20.38522268
108PRKAA10.38012876
109MAPK130.36258200
110PRKCI0.35153467
111RAF10.34891937
112BMPR1B0.34551183
113CSNK1E0.33956866
114FGFR10.33865303
115PRKAA20.33275531
116STK380.32880865
117MAPK10.32174077
118MAP2K70.32000729
119NEK90.30713214
120SMG10.29214417
121JAK30.28469108
122CSNK1A1L0.28210829
123CLK10.25207752
124MET0.24086570
125ABL10.22659472

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.84883798
2* Fanconi anemia pathway_Homo sapiens_hsa034603.82111222
3Mismatch repair_Homo sapiens_hsa034303.65648616
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.54398794
5Cell cycle_Homo sapiens_hsa041103.46570053
6* Homologous recombination_Homo sapiens_hsa034403.13306348
7Non-homologous end-joining_Homo sapiens_hsa034503.09658826
8Basal transcription factors_Homo sapiens_hsa030223.02873934
9RNA polymerase_Homo sapiens_hsa030202.87265076
10RNA transport_Homo sapiens_hsa030132.75942672
11Nucleotide excision repair_Homo sapiens_hsa034202.61346788
12Base excision repair_Homo sapiens_hsa034102.54846307
13Spliceosome_Homo sapiens_hsa030402.31011865
14RNA degradation_Homo sapiens_hsa030182.27002050
15One carbon pool by folate_Homo sapiens_hsa006702.17890428
16mRNA surveillance pathway_Homo sapiens_hsa030152.17451979
17p53 signaling pathway_Homo sapiens_hsa041152.11021278
18Pyrimidine metabolism_Homo sapiens_hsa002401.96949248
19Vitamin B6 metabolism_Homo sapiens_hsa007501.87990955
20Protein export_Homo sapiens_hsa030601.73449889
21Systemic lupus erythematosus_Homo sapiens_hsa053221.60962523
22Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.54368470
23Cysteine and methionine metabolism_Homo sapiens_hsa002701.49573611
24Herpes simplex infection_Homo sapiens_hsa051681.40716229
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.39209930
26Purine metabolism_Homo sapiens_hsa002301.30761854
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.21591701
28MicroRNAs in cancer_Homo sapiens_hsa052061.19793315
29Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.18977778
30Oocyte meiosis_Homo sapiens_hsa041141.16784968
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.16631661
32Propanoate metabolism_Homo sapiens_hsa006401.11604075
33Viral carcinogenesis_Homo sapiens_hsa052031.04368150
34Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.03437333
35Epstein-Barr virus infection_Homo sapiens_hsa051691.01644124
36Transcriptional misregulation in cancer_Homo sapiens_hsa052021.00661718
37Lysine degradation_Homo sapiens_hsa003100.98979677
38NF-kappa B signaling pathway_Homo sapiens_hsa040640.95382421
39TGF-beta signaling pathway_Homo sapiens_hsa043500.88846609
40Steroid biosynthesis_Homo sapiens_hsa001000.84058455
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.82412662
42Pyruvate metabolism_Homo sapiens_hsa006200.82221574
43Basal cell carcinoma_Homo sapiens_hsa052170.82084201
44Small cell lung cancer_Homo sapiens_hsa052220.81883376
45HTLV-I infection_Homo sapiens_hsa051660.81841318
46Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.80051823
47Folate biosynthesis_Homo sapiens_hsa007900.75076488
48Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.73712844
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.70646648
50Measles_Homo sapiens_hsa051620.68462791
51Alcoholism_Homo sapiens_hsa050340.68316237
52Influenza A_Homo sapiens_hsa051640.67753125
53Intestinal immune network for IgA production_Homo sapiens_hsa046720.67123000
54Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.66682904
55NOD-like receptor signaling pathway_Homo sapiens_hsa046210.66554456
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.61378550
57Linoleic acid metabolism_Homo sapiens_hsa005910.59200032
58Hematopoietic cell lineage_Homo sapiens_hsa046400.59098243
59Vitamin digestion and absorption_Homo sapiens_hsa049770.58065073
60Notch signaling pathway_Homo sapiens_hsa043300.56830512
61Dorso-ventral axis formation_Homo sapiens_hsa043200.56331542
62Fatty acid elongation_Homo sapiens_hsa000620.55641887
63Biosynthesis of amino acids_Homo sapiens_hsa012300.55316901
64Circadian rhythm_Homo sapiens_hsa047100.53933223
65alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.52164986
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.51369671
672-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.51038553
68Hepatitis B_Homo sapiens_hsa051610.50006712
69Ovarian steroidogenesis_Homo sapiens_hsa049130.50002733
70Hippo signaling pathway_Homo sapiens_hsa043900.49576315
71Jak-STAT signaling pathway_Homo sapiens_hsa046300.49243001
72Arachidonic acid metabolism_Homo sapiens_hsa005900.49220385
73Prostate cancer_Homo sapiens_hsa052150.49204298
74Glutathione metabolism_Homo sapiens_hsa004800.49166832
75FoxO signaling pathway_Homo sapiens_hsa040680.48832034
76Wnt signaling pathway_Homo sapiens_hsa043100.48134400
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47226667
78Primary immunodeficiency_Homo sapiens_hsa053400.47141757
79Sphingolipid metabolism_Homo sapiens_hsa006000.46805130
80Colorectal cancer_Homo sapiens_hsa052100.46430619
81Huntingtons disease_Homo sapiens_hsa050160.46082631
82Hedgehog signaling pathway_Homo sapiens_hsa043400.45259919
83RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.43258444
84Pentose phosphate pathway_Homo sapiens_hsa000300.42877751
85* Pathways in cancer_Homo sapiens_hsa052000.41402522
86Phototransduction_Homo sapiens_hsa047440.40893754
87Adherens junction_Homo sapiens_hsa045200.40735540
88Inositol phosphate metabolism_Homo sapiens_hsa005620.39997972
89Autoimmune thyroid disease_Homo sapiens_hsa053200.39156419
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.38792496
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38422777
92Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.38282998
93Ribosome_Homo sapiens_hsa030100.38125615
94Carbon metabolism_Homo sapiens_hsa012000.36394987
95Melanoma_Homo sapiens_hsa052180.36290098
96Ether lipid metabolism_Homo sapiens_hsa005650.35769672
97Apoptosis_Homo sapiens_hsa042100.35115993
98Selenocompound metabolism_Homo sapiens_hsa004500.34411144
99Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.34160079
100Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.33661092
101Asthma_Homo sapiens_hsa053100.30732082
102Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.30245615
103Antigen processing and presentation_Homo sapiens_hsa046120.30088003
104Fatty acid metabolism_Homo sapiens_hsa012120.29084518
105Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.28464329
106N-Glycan biosynthesis_Homo sapiens_hsa005100.28400471
107Metabolic pathways_Homo sapiens_hsa011000.27489451
108TNF signaling pathway_Homo sapiens_hsa046680.26953311
109Regulation of autophagy_Homo sapiens_hsa041400.26362629
110Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.26238583
111Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.25743007
112Chronic myeloid leukemia_Homo sapiens_hsa052200.24748747
113Choline metabolism in cancer_Homo sapiens_hsa052310.23584725
114Thyroid hormone signaling pathway_Homo sapiens_hsa049190.23579886
115Allograft rejection_Homo sapiens_hsa053300.22826447
116Butanoate metabolism_Homo sapiens_hsa006500.21908830
117Drug metabolism - other enzymes_Homo sapiens_hsa009830.21889597
118Prolactin signaling pathway_Homo sapiens_hsa049170.21097041
119Thyroid cancer_Homo sapiens_hsa052160.20776667
120Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.20642432
121Endometrial cancer_Homo sapiens_hsa052130.19527867
122Parkinsons disease_Homo sapiens_hsa050120.19487624
123Caffeine metabolism_Homo sapiens_hsa002320.19373978
124Graft-versus-host disease_Homo sapiens_hsa053320.19212223
125Fatty acid biosynthesis_Homo sapiens_hsa000610.18764316
126Proteasome_Homo sapiens_hsa030500.18055218
127Glycerophospholipid metabolism_Homo sapiens_hsa005640.17864146
128Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.16027777
129Phosphatidylinositol signaling system_Homo sapiens_hsa040700.15778549
130Longevity regulating pathway - mammal_Homo sapiens_hsa042110.15655668
131PI3K-Akt signaling pathway_Homo sapiens_hsa041510.15338226
132Regulation of actin cytoskeleton_Homo sapiens_hsa048100.14306647
133Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.11748076
134Olfactory transduction_Homo sapiens_hsa047400.11169419
135Non-small cell lung cancer_Homo sapiens_hsa052230.10800022
136Pentose and glucuronate interconversions_Homo sapiens_hsa000400.10702425
137Tryptophan metabolism_Homo sapiens_hsa003800.06065295
138Fatty acid degradation_Homo sapiens_hsa000710.04807202
139Oxidative phosphorylation_Homo sapiens_hsa001900.03994287
140Bladder cancer_Homo sapiens_hsa052190.03468401
141Peroxisome_Homo sapiens_hsa041460.01284707
142Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.00759509

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