BRAT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this ubiquitously expressed gene interacts with the tumor suppressing BRCA1 (breast cancer 1) protein and and the ATM (ataxia telangiectasia mutated) protein. ATM is thought to be a master controller of cell cycle checkpoint signalling pathways that are required for cellular responses to DNA damage such as double-strand breaks that are induced by ionizing radiation and complexes with BRCA1 in the multi-protein complex BASC (BRAC1-associated genome surveillance complex). The protein encoded by this gene is thought to play a role in the DNA damage pathway regulated by BRCA1 and ATM. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane organization (GO:0097090)6.41412254
2histone H3-K36 demethylation (GO:0070544)6.02175997
3negative regulation of erythrocyte differentiation (GO:0045647)5.39916588
4regulation of telomere maintenance via telomerase (GO:0032210)5.37919589
5regulation of translational fidelity (GO:0006450)4.82419119
6regulation of mitochondrial depolarization (GO:0051900)4.66256775
7negative regulation of cell size (GO:0045792)4.65751126
8positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.58157128
9negative regulation of glycoprotein biosynthetic process (GO:0010561)4.38534096
10regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.19768877
11apoptotic process involved in morphogenesis (GO:0060561)4.16212970
12DNA topological change (GO:0006265)4.05450440
13regulation of chromatin binding (GO:0035561)4.04718264
14regulation of mammary gland epithelial cell proliferation (GO:0033599)3.98173392
15presynaptic membrane assembly (GO:0097105)3.91760590
16DNA unwinding involved in DNA replication (GO:0006268)3.90679256
17semaphorin-plexin signaling pathway (GO:0071526)3.82500154
18folic acid-containing compound biosynthetic process (GO:0009396)3.76703153
19erythrocyte maturation (GO:0043249)3.75459157
20proline biosynthetic process (GO:0006561)3.69927763
21intracellular estrogen receptor signaling pathway (GO:0030520)3.66477021
22UV protection (GO:0009650)3.65412909
23activation of Rac GTPase activity (GO:0032863)3.61359458
24histone H4 deacetylation (GO:0070933)3.55954790
25negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.53253594
26antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.47782969
27antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.47782969
28positive regulation of gene expression, epigenetic (GO:0045815)3.43602795
29regulation of histone H3-K27 methylation (GO:0061085)3.43251075
30positive regulation of histone deacetylation (GO:0031065)3.41300492
31negative regulation of gene silencing (GO:0060969)3.39629810
32response to muramyl dipeptide (GO:0032495)3.39548498
33GDP-mannose metabolic process (GO:0019673)3.37683559
34response to peptidoglycan (GO:0032494)3.37376975
35regulation of protein glycosylation (GO:0060049)3.36981356
36positive regulation of gamma-delta T cell activation (GO:0046645)3.36448966
37snRNA metabolic process (GO:0016073)3.35961046
38modulation by virus of host process (GO:0019054)3.32734926
39histone H3-K9 demethylation (GO:0033169)3.31026540
40establishment of mitochondrion localization (GO:0051654)3.30885769
41protein retention in ER lumen (GO:0006621)3.24476532
42glucose catabolic process (GO:0006007)3.21939145
43NIK/NF-kappaB signaling (GO:0038061)3.20192229
44L-serine metabolic process (GO:0006563)3.17465456
45regulation of somitogenesis (GO:0014807)3.15964636
46negative regulation of histone methylation (GO:0031061)3.12840127
47histone H3 deacetylation (GO:0070932)3.09058161
48negative regulation of DNA-templated transcription, elongation (GO:0032785)3.06259768
49mitochondrial DNA metabolic process (GO:0032042)3.03777794
50pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)3.03415475
51UMP biosynthetic process (GO:0006222)3.03415475
52pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)3.03415475
53UMP metabolic process (GO:0046049)3.03415475
54negative regulation of synaptic transmission, GABAergic (GO:0032229)3.03166611
55positive regulation of Cdc42 GTPase activity (GO:0043089)3.03078841
56negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.98147617
57cellular response to virus (GO:0098586)2.98044664
58regulation of telomere maintenance (GO:0032204)2.96925135
59negative regulation of glycoprotein metabolic process (GO:1903019)2.95808550
60negative regulation of glial cell proliferation (GO:0060253)2.95690035
61antigen processing and presentation of endogenous antigen (GO:0019883)2.95620459
62folic acid metabolic process (GO:0046655)2.93756729
63positive regulation of protein deacetylation (GO:0090312)2.93001683
64negative regulation of myotube differentiation (GO:0010832)2.92490725
65snRNA processing (GO:0016180)2.92133535
66pentose-phosphate shunt (GO:0006098)2.90696249
673-UTR-mediated mRNA stabilization (GO:0070935)2.90201265
68positive thymic T cell selection (GO:0045059)2.89887474
69epithelial cell differentiation involved in prostate gland development (GO:0060742)2.88699388
70protein kinase C signaling (GO:0070528)2.88520662
71cellular hyperosmotic response (GO:0071474)2.88333141
72maternal placenta development (GO:0001893)2.88164471
73nucleosome disassembly (GO:0006337)2.87391637
74protein-DNA complex disassembly (GO:0032986)2.87391637
75regulation of translational elongation (GO:0006448)2.86552531
76astrocyte development (GO:0014002)2.86100537
77activation of JUN kinase activity (GO:0007257)2.86017727
78negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.85953817
79planar cell polarity pathway involved in neural tube closure (GO:0090179)2.85809834
80pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.85320274
81regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.84152248
82negative regulation of viral release from host cell (GO:1902187)2.83704812
83apoptotic process involved in development (GO:1902742)2.83159360
84DNA strand elongation involved in DNA replication (GO:0006271)2.82761164
85chromatin silencing (GO:0006342)2.81740776
86modulation by symbiont of host cellular process (GO:0044068)2.81193030
87peptidyl-arginine omega-N-methylation (GO:0035247)2.79881070
88pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.79043388
89negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.78682276
90negative regulation of cell killing (GO:0031342)2.78682276
91nucleobase biosynthetic process (GO:0046112)2.78076807
92positive regulation of pseudopodium assembly (GO:0031274)2.78064833
93positive regulation of B cell differentiation (GO:0045579)2.76238443
94regulation of gamma-delta T cell differentiation (GO:0045586)2.76187142
95mannose metabolic process (GO:0006013)2.75912468
96regulation of translational termination (GO:0006449)2.75794227
97IMP biosynthetic process (GO:0006188)2.75244912
98positive regulation of growth hormone secretion (GO:0060124)2.74740603
99NADPH regeneration (GO:0006740)2.74607327
100phosphatidylglycerol biosynthetic process (GO:0006655)2.74307160
101regulation of chromatin silencing (GO:0031935)2.74036094
102spliceosomal tri-snRNP complex assembly (GO:0000244)2.73591942
103ncRNA 3-end processing (GO:0043628)2.73353697
104maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.73019607
105histone H4-K12 acetylation (GO:0043983)2.72789348
106DNA strand elongation (GO:0022616)2.71075475
107regulation of histone deacetylation (GO:0031063)2.69316995
108regulation of NFAT protein import into nucleus (GO:0051532)2.68915378
109cell-cell junction maintenance (GO:0045217)2.67415380
110negative regulation of B cell apoptotic process (GO:0002903)2.67412674
111atrioventricular valve morphogenesis (GO:0003181)2.67250003
112Golgi transport vesicle coating (GO:0048200)2.66910946
113COPI coating of Golgi vesicle (GO:0048205)2.66910946
114establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.66812353
115mitochondrion transport along microtubule (GO:0047497)2.66812353
116pentose metabolic process (GO:0019321)2.66236009
117glucocorticoid receptor signaling pathway (GO:0042921)2.65582827
118retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.64750784
119peptidyl-arginine N-methylation (GO:0035246)2.64417968
120peptidyl-arginine methylation (GO:0018216)2.64417968
121protein localization to endosome (GO:0036010)2.63000029
122histone H2A monoubiquitination (GO:0035518)2.62714538
123negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.60958989
124cell-substrate adherens junction assembly (GO:0007045)2.60845028
125focal adhesion assembly (GO:0048041)2.60845028
126granulocyte differentiation (GO:0030851)2.60451207
127purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.60278803
128histone H2A acetylation (GO:0043968)2.59643921
129mitotic nuclear envelope disassembly (GO:0007077)2.59090394
130nerve growth factor signaling pathway (GO:0038180)2.59029230
131DNA duplex unwinding (GO:0032508)2.59025356
132modulation by virus of host morphology or physiology (GO:0019048)2.58915272
133regulation of leukocyte degranulation (GO:0043300)2.58458927
134protein insertion into membrane (GO:0051205)2.58449719
135positive regulation by symbiont of host defense response (GO:0052509)2.58273991
136modulation by symbiont of host defense response (GO:0052031)2.58273991
137modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.58273991
138modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.58273991
139positive regulation by organism of defense response of other organism involved in symbiotic interact2.58273991
140modulation by symbiont of host immune response (GO:0052553)2.58273991
141regulation of type I interferon-mediated signaling pathway (GO:0060338)2.58159294
142alternative mRNA splicing, via spliceosome (GO:0000380)2.57961361
143negative T cell selection (GO:0043383)2.57926060
144cytokinetic process (GO:0032506)2.57647525
145mitochondrial RNA metabolic process (GO:0000959)2.57434534
146DNA replication initiation (GO:0006270)2.57097558
147adherens junction assembly (GO:0034333)2.57089169
148negative regulation of protein oligomerization (GO:0032460)2.56287310
149regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.55960255
150histone H4 acetylation (GO:0043967)2.55820054
151mannosylation (GO:0097502)2.55795858
152pyrimidine nucleoside salvage (GO:0043097)2.54762790
153pyrimidine-containing compound salvage (GO:0008655)2.54762790
154proline metabolic process (GO:0006560)2.54291106
155positive regulation of dendrite morphogenesis (GO:0050775)2.53454080
156cellular response to interleukin-4 (GO:0071353)2.52663954
157regulation of gamma-delta T cell activation (GO:0046643)2.52573337
158negative regulation of granulocyte differentiation (GO:0030853)2.52298056
159response to laminar fluid shear stress (GO:0034616)2.50866245
160regulation of myeloid leukocyte mediated immunity (GO:0002886)2.50517345
161tRNA methylation (GO:0030488)2.50384617
162Golgi to endosome transport (GO:0006895)2.50082546
163DNA geometric change (GO:0032392)2.50011423
164positive regulation of cell cycle checkpoint (GO:1901978)2.49504960
165histone H4-K8 acetylation (GO:0043982)2.48231880
166histone H4-K5 acetylation (GO:0043981)2.48231880
167detection of bacterium (GO:0016045)2.48053517
168maturation of 5.8S rRNA (GO:0000460)2.47927391
169amino acid activation (GO:0043038)2.47671007
170tRNA aminoacylation (GO:0043039)2.47671007
171receptor recycling (GO:0001881)2.47659050
172negative thymic T cell selection (GO:0045060)2.46247849
173leukocyte aggregation (GO:0070486)2.46053706
174positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.44579778
175regulation of ARF GTPase activity (GO:0032312)2.44396056
176protein localization to kinetochore (GO:0034501)2.44241134
177thymic T cell selection (GO:0045061)2.44120436
178histone deacetylation (GO:0016575)2.43494609
179regulation of hydrogen peroxide metabolic process (GO:0010310)2.43327825
180T cell selection (GO:0045058)2.42350485
181mitotic chromosome condensation (GO:0007076)2.41797160
182interferon-gamma secretion (GO:0072643)2.41370223
183lung morphogenesis (GO:0060425)2.41270605

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.96802253
2MYC_22102868_ChIP-Seq_BL_Human3.96012904
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.99016076
4EGR1_19374776_ChIP-ChIP_THP-1_Human2.88594601
5VDR_21846776_ChIP-Seq_THP-1_Human2.81736482
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.75327228
7FOXM1_23109430_ChIP-Seq_U2OS_Human2.46571030
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.38023828
9VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.17610142
10KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.16036903
11KDM2B_26808549_Chip-Seq_DND41_Human2.14357204
12DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.02421526
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.00472048
14RARG_19884340_ChIP-ChIP_MEFs_Mouse1.99917995
15TCF7_22412390_ChIP-Seq_EML_Mouse1.99842878
16E2F4_17652178_ChIP-ChIP_JURKAT_Human1.99649519
17STAT6_21828071_ChIP-Seq_BEAS2B_Human1.96610409
18KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.95141289
19TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.94047205
20CIITA_25753668_ChIP-Seq_RAJI_Human1.90957670
21CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.90781073
22KDM2B_26808549_Chip-Seq_SUP-B15_Human1.87927358
23TET1_21451524_ChIP-Seq_MESCs_Mouse1.86355827
24VDR_24763502_ChIP-Seq_THP-1_Human1.81235771
25ELK3_25401928_ChIP-Seq_HUVEC_Human1.79785159
26MYC_18555785_ChIP-Seq_MESCs_Mouse1.78118839
27UTX_26944678_Chip-Seq_JUKART_Human1.77958946
28MAF_26560356_Chip-Seq_TH1_Human1.76818356
29PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.75808603
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.72697818
31EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.72421960
32E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.69675526
33RUNX_20019798_ChIP-Seq_JUKART_Human1.68081337
34MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.64933072
35CTCF_27219007_Chip-Seq_ERYTHROID_Human1.64481707
36XRN2_22483619_ChIP-Seq_HELA_Human1.63528922
37SA1_27219007_Chip-Seq_ERYTHROID_Human1.62673112
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.61519275
39CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.60219335
40NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.58743007
41MYC_18358816_ChIP-ChIP_MESCs_Mouse1.55685599
42TP63_17297297_ChIP-ChIP_HaCaT_Human1.54416202
43TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.53936745
44ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.53625678
45MYC_19079543_ChIP-ChIP_MESCs_Mouse1.52416071
46FOXP3_21729870_ChIP-Seq_TREG_Human1.50629211
47DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.50479561
48SMC4_20622854_ChIP-Seq_HELA_Human1.50082063
49GATA1_19941827_ChIP-Seq_MEL_Mouse1.48638304
50TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.48259483
51RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.48079192
52BCL6_27268052_Chip-Seq_Bcells_Human1.46897728
53P68_20966046_ChIP-Seq_HELA_Human1.46238282
54LXR_22292898_ChIP-Seq_THP-1_Human1.46210029
55ERG_21242973_ChIP-ChIP_JURKAT_Human1.45662028
56EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.44858200
57BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.44117071
58GABP_19822575_ChIP-Seq_HepG2_Human1.43615656
59UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.40156833
60GATA1_22383799_ChIP-Seq_G1ME_Mouse1.38813730
61NELFA_20434984_ChIP-Seq_ESCs_Mouse1.38259597
62SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.38123608
63TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.38115282
64CREB1_26743006_Chip-Seq_LNCaP_Human1.36594194
65SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.35963326
66KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.35682124
67MYB_26560356_Chip-Seq_TH2_Human1.35586875
68STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.34449914
69ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.33929640
70ZNF263_19887448_ChIP-Seq_K562_Human1.33570916
71MYB_26560356_Chip-Seq_TH1_Human1.33275022
72ETS1_20019798_ChIP-Seq_JURKAT_Human1.30523786
73E2F1_21310950_ChIP-Seq_MCF-7_Human1.27899057
74KDM5A_27292631_Chip-Seq_BREAST_Human1.27631323
75SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.26798578
76FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.26198230
77JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.26146942
78SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.24083642
79CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.24060513
80SPI1_23127762_ChIP-Seq_K562_Human1.24048598
81ZFX_18555785_ChIP-Seq_MESCs_Mouse1.23794465
82KDM2B_26808549_Chip-Seq_JURKAT_Human1.23794303
83KLF4_18555785_ChIP-Seq_MESCs_Mouse1.22474809
84POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.22436813
85CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.22094626
86MYC_19030024_ChIP-ChIP_MESCs_Mouse1.21850219
87SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.19440122
88PU.1_20513432_ChIP-Seq_Bcells_Mouse1.19246972
89CTCF_26484167_Chip-Seq_Bcells_Mouse1.18855331
90SRY_22984422_ChIP-ChIP_TESTIS_Rat1.18725171
91RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18521305
92HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.17680983
93ELF1_17652178_ChIP-ChIP_JURKAT_Human1.16709461
94SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16371653
95CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.16125545
96NCOR1_26117541_ChIP-Seq_K562_Human1.15715704
97ZFP281_18757296_ChIP-ChIP_E14_Mouse1.15609674
98NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.15451161
99DNAJC2_21179169_ChIP-ChIP_NT2_Human1.14266140
100PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14265502
101CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.13416895
102THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.13194544
103MAF_26560356_Chip-Seq_TH2_Human1.13177100
104MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.12764192
105FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.12735076
106CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.12519849
107SCL_19346495_ChIP-Seq_HPC-7_Human1.11370097
108E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.11245316
109CTCF_27219007_Chip-Seq_Bcells_Human1.11225133
110TP53_22127205_ChIP-Seq_IMR90_Human1.11125300
111FOXP1_21924763_ChIP-Seq_HESCs_Human1.11011953
112ELF1_20517297_ChIP-Seq_JURKAT_Human1.10853643
113CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.10760681
114YY1_22570637_ChIP-Seq_MALME-3M_Human1.10543006
115RACK7_27058665_Chip-Seq_MCF-7_Human1.10488806
116CTCF_21964334_ChIP-Seq_BJAB-B_Human1.10314364
117RARB_24833708_ChIP-Seq_LIVER_Mouse1.09470492
118MYCN_18555785_ChIP-Seq_MESCs_Mouse1.08962968
119TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08502778
120GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.07876931
121RARA_24833708_ChIP-Seq_LIVER_Mouse1.07843503
122YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07641176
123ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.07018677
124KDM2B_26808549_Chip-Seq_K562_Human1.06846808
125PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.06333491
126SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.06261794
127RUNX1_27514584_Chip-Seq_MCF-7_Human1.05765568
128MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.05481847
129RUNX1_22412390_ChIP-Seq_EML_Mouse1.05401440
130KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.04953502
131ATF3_27146783_Chip-Seq_COLON_Human1.04767588
132ESR2_21235772_ChIP-Seq_MCF-7_Human1.04463384
133PHF8_20622854_ChIP-Seq_HELA_Human1.04255219
134BRD4_27068464_Chip-Seq_AML-cells_Mouse1.03800247
135ETS1_21867929_ChIP-Seq_TH2_Mouse1.03468805
136ZFP281_27345836_Chip-Seq_ESCs_Mouse1.03459769
137E2F1_20622854_ChIP-Seq_HELA_Human1.03215369
138BCOR_27268052_Chip-Seq_Bcells_Human1.03073723
139MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.03043076
140AR_21909140_ChIP-Seq_LNCAP_Human1.03041085
141P300_27058665_Chip-Seq_ZR-75-30cells_Human1.02336858
142GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02176071
143PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02000468
144RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.01793540
145CTCF_21964334_Chip-Seq_Bcells_Human1.01393368

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system5.19926896
2MP0003303_peritoneal_inflammation3.60607160
3MP0003705_abnormal_hypodermis_morpholog3.11599282
4MP0005451_abnormal_body_composition2.92915726
5MP0001849_ear_inflammation2.90055555
6MP0003111_abnormal_nucleus_morphology2.78634992
7MP0005076_abnormal_cell_differentiation2.75272679
8MP0005075_abnormal_melanosome_morpholog2.72250963
9MP0003436_decreased_susceptibility_to2.71590662
10MP0009278_abnormal_bone_marrow2.65177506
11MP0003172_abnormal_lysosome_physiology2.50221596
12MP0004859_abnormal_synaptic_plasticity2.39844033
13MP0009840_abnormal_foam_cell2.34267609
14MP0000465_gastrointestinal_hemorrhage2.25366689
15MP0000747_muscle_weakness2.20655219
16MP0002249_abnormal_larynx_morphology2.17008388
17MP0003300_gastrointestinal_ulcer2.10934702
18MP0001730_embryonic_growth_arrest2.09483466
19MP0000678_abnormal_parathyroid_gland2.07886441
20MP0004381_abnormal_hair_follicle2.05465409
21MP0008260_abnormal_autophagy2.03863333
22MP0010094_abnormal_chromosome_stability2.00332560
23MP0001545_abnormal_hematopoietic_system1.95092591
24MP0005397_hematopoietic_system_phenotyp1.95092591
25MP0000015_abnormal_ear_pigmentation1.94182191
26MP0010352_gastrointestinal_tract_polyps1.90587713
27MP0003329_amyloid_beta_deposits1.85141123
28MP0002735_abnormal_chemical_nociception1.79893074
29MP0004858_abnormal_nervous_system1.76822093
30MP0005670_abnormal_white_adipose1.72890912
31MP0004130_abnormal_muscle_cell1.72883176
32MP0004147_increased_porphyrin_level1.68559266
33MP0003806_abnormal_nucleotide_metabolis1.66813054
34MP0002398_abnormal_bone_marrow1.65286683
35MP0005409_darkened_coat_color1.59622344
36MP0005666_abnormal_adipose_tissue1.59424807
37MP0003656_abnormal_erythrocyte_physiolo1.56550526
38MP0004947_skin_inflammation1.54628784
39MP0001348_abnormal_lacrimal_gland1.53410878
40MP0000703_abnormal_thymus_morphology1.51885490
41MP0000920_abnormal_myelination1.50700738
42MP0010030_abnormal_orbit_morphology1.46739263
43MP0003453_abnormal_keratinocyte_physiol1.46459672
44MP0002089_abnormal_postnatal_growth/wei1.46313447
45MP0008877_abnormal_DNA_methylation1.44299606
46MP0004185_abnormal_adipocyte_glucose1.43761955
47MP0001661_extended_life_span1.42628117
48MP0005501_abnormal_skin_physiology1.39837770
49MP0005058_abnormal_lysosome_morphology1.39702566
50MP0003077_abnormal_cell_cycle1.38193404
51MP0000858_altered_metastatic_potential1.36914251
52MP0003763_abnormal_thymus_physiology1.36848600
53MP0005671_abnormal_response_to1.35895793
54MP0001873_stomach_inflammation1.32289976
55MP0001529_abnormal_vocalization1.31496020
56MP0001800_abnormal_humoral_immune1.31364894
57MP0002722_abnormal_immune_system1.31291454
58MP0000689_abnormal_spleen_morphology1.30338767
59MP0005174_abnormal_tail_pigmentation1.30025886
60MP0008961_abnormal_basal_metabolism1.29481310
61MP0005025_abnormal_response_to1.29033169
62MP0005375_adipose_tissue_phenotype1.27296119
63MP0004270_analgesia1.26368057
64MP0002419_abnormal_innate_immunity1.25304593
65MP0000750_abnormal_muscle_regeneration1.23341519
66MP0000003_abnormal_adipose_tissue1.21626125
67MP0004808_abnormal_hematopoietic_stem1.20553566
68MP0002429_abnormal_blood_cell1.20158955
69MP0004957_abnormal_blastocyst_morpholog1.19992941
70MP0008995_early_reproductive_senescence1.19369129
71MP0002080_prenatal_lethality1.17721228
72MP0000537_abnormal_urethra_morphology1.16218142
73MP0002269_muscular_atrophy1.15275210
74MP0002736_abnormal_nociception_after1.13782636
75MP0000716_abnormal_immune_system1.13290672
76MP0000604_amyloidosis1.12209331
77MP0002796_impaired_skin_barrier1.11518542
78MP0008057_abnormal_DNA_replication1.10164395
79MP0004233_abnormal_muscle_weight1.09490336
80MP0002086_abnormal_extraembryonic_tissu1.09226073
81MP0005171_absent_coat_pigmentation1.08997200
82MP0009333_abnormal_splenocyte_physiolog1.08310755
83MP0003984_embryonic_growth_retardation1.07746862
84MP0005365_abnormal_bile_salt1.07275052
85MP0000751_myopathy1.06563488
86MP0001485_abnormal_pinna_reflex1.06130529
87MP0005083_abnormal_biliary_tract1.05608162
88MP0000685_abnormal_immune_system1.04478122
89MP0006054_spinal_hemorrhage1.04463797
90MP0005464_abnormal_platelet_physiology1.03576273
91MP0000490_abnormal_crypts_of1.02333806
92MP0002088_abnormal_embryonic_growth/wei1.01445190
93MP0008007_abnormal_cellular_replicative1.00848602
94MP0005380_embryogenesis_phenotype1.00824239
95MP0001672_abnormal_embryogenesis/_devel1.00824239
96MP0008569_lethality_at_weaning1.00385964
97MP0002938_white_spotting0.99836832
98MP0003635_abnormal_synaptic_transmissio0.99232783
99MP0003634_abnormal_glial_cell0.99204017
100MP0002085_abnormal_embryonic_tissue0.98719972
101MP0002095_abnormal_skin_pigmentation0.96722770
102MP0009672_abnormal_birth_weight0.95666163
103MP0009384_cardiac_valve_regurgitation0.95195905
104MP0009931_abnormal_skin_appearance0.94599412
105MP0008058_abnormal_DNA_repair0.94414204
106MP0003879_abnormal_hair_cell0.94322378
107MP0000371_diluted_coat_color0.93614183
108MP0002084_abnormal_developmental_patter0.92793193
109MP0005000_abnormal_immune_tolerance0.92665531
110MP0002970_abnormal_white_adipose0.92474751
111MP0003191_abnormal_cellular_cholesterol0.92435691
112MP0004885_abnormal_endolymph0.91864026
113MP0000733_abnormal_muscle_development0.91610680
114MP0001533_abnormal_skeleton_physiology0.91494636
115MP0000681_abnormal_thyroid_gland0.90407720
116MP0002019_abnormal_tumor_incidence0.89437368
117MP0000313_abnormal_cell_death0.88558832
118MP0002420_abnormal_adaptive_immunity0.87942186
119MP0005621_abnormal_cell_physiology0.87637197
120MP0008770_decreased_survivor_rate0.87548068
121MP0001915_intracranial_hemorrhage0.85879563
122MP0002405_respiratory_system_inflammati0.85866072
123MP0002932_abnormal_joint_morphology0.85628671
124MP0002998_abnormal_bone_remodeling0.84476190
125MP0001697_abnormal_embryo_size0.83019659
126MP0006292_abnormal_olfactory_placode0.82440834
127MP0010155_abnormal_intestine_physiology0.82398162
128MP0002132_abnormal_respiratory_system0.82321114
129MP0001819_abnormal_immune_cell0.82007042
130MP0005387_immune_system_phenotype0.81827074
131MP0001790_abnormal_immune_system0.81827074
132MP0008932_abnormal_embryonic_tissue0.81824669
133MP0000609_abnormal_liver_physiology0.81617608
134MP0003693_abnormal_embryo_hatching0.80936913
135MP0003123_paternal_imprinting0.79775593
136MP0004811_abnormal_neuron_physiology0.79757475
137MP0000350_abnormal_cell_proliferation0.79757085
138MP0003866_abnormal_defecation0.79702572
139MP0003091_abnormal_cell_migration0.79581232
140MP0005360_urolithiasis0.79558734
141MP0002452_abnormal_antigen_presenting0.79531437
142MP0005257_abnormal_intraocular_pressure0.79413408
143MP0002064_seizures0.79295125
144MP0003115_abnormal_respiratory_system0.78564883
145MP0000955_abnormal_spinal_cord0.77670988
146MP0002075_abnormal_coat/hair_pigmentati0.77392615
147MP0003183_abnormal_peptide_metabolism0.77047323
148MP0005390_skeleton_phenotype0.75861734
149MP0002272_abnormal_nervous_system0.75770777
150MP0004264_abnormal_extraembryonic_tissu0.75450451
151MP0002723_abnormal_immune_serum0.74840106
152MP0002254_reproductive_system_inflammat0.73400734
153MP0000477_abnormal_intestine_morphology0.72612843
154MP0001835_abnormal_antigen_presentation0.72173815
155MP0002877_abnormal_melanocyte_morpholog0.71831082
156MP0003566_abnormal_cell_adhesion0.69252313

Predicted human phenotypes

RankGene SetZ-score
1Cerebellar dysplasia (HP:0007033)6.73052542
2Type II lissencephaly (HP:0007260)5.36347388
3Retinal atrophy (HP:0001105)4.24024464
4Abnormality of the lower motor neuron (HP:0002366)4.08665556
5Hyperacusis (HP:0010780)3.55949158
6Obstructive sleep apnea (HP:0002870)3.50386012
7Abnormality of the astrocytes (HP:0100707)3.48935345
8Astrocytoma (HP:0009592)3.48935345
9Slender build (HP:0001533)3.20651596
10Broad face (HP:0000283)3.15932901
11J-shaped sella turcica (HP:0002680)3.09400059
12Ulnar bowing (HP:0003031)3.05372500
13Severe muscular hypotonia (HP:0006829)3.02112405
14Broad distal phalanx of finger (HP:0009836)2.91372951
15Eczematoid dermatitis (HP:0000976)2.86781593
16Thin bony cortex (HP:0002753)2.86440333
17Abnormality of glycolysis (HP:0004366)2.78905730
18Increased serum pyruvate (HP:0003542)2.78905730
19Ependymoma (HP:0002888)2.77354132
20Hemorrhage of the eye (HP:0011885)2.76373183
21Biconcave vertebral bodies (HP:0004586)2.65347021
22Panhypogammaglobulinemia (HP:0003139)2.63943142
23Difficulty climbing stairs (HP:0003551)2.63071227
24Buphthalmos (HP:0000557)2.62349563
25Frequent falls (HP:0002359)2.61472637
26Cellulitis (HP:0100658)2.60358752
27Amyotrophic lateral sclerosis (HP:0007354)2.60355815
28Colitis (HP:0002583)2.60092426
29Vertebral compression fractures (HP:0002953)2.59961177
30Aplasia/Hypoplasia of the brainstem (HP:0007362)2.59702752
31Hypoplasia of the brainstem (HP:0002365)2.59702752
32Cerebral hypomyelination (HP:0006808)2.56627655
33Upper motor neuron abnormality (HP:0002127)2.54380312
34Abnormality of the pons (HP:0007361)2.53679677
35Annular pancreas (HP:0001734)2.49926755
36Medulloblastoma (HP:0002885)2.48783862
37Visual hallucinations (HP:0002367)2.47012740
38Spastic gait (HP:0002064)2.46622253
39Abnormality of the thoracic spine (HP:0100711)2.45589857
40Megalocornea (HP:0000485)2.44689747
41Overriding aorta (HP:0002623)2.44539239
42Hand muscle atrophy (HP:0009130)2.42992967
43Glioma (HP:0009733)2.42922975
44Limb-girdle muscle weakness (HP:0003325)2.41969556
45Hypoplasia of the pons (HP:0012110)2.41902756
46Cervical subluxation (HP:0003308)2.41446225
47Chronic otitis media (HP:0000389)2.41354261
48Albinism (HP:0001022)2.40601264
49Dysostosis multiplex (HP:0000943)2.39529929
50Insomnia (HP:0100785)2.38056100
51Increased connective tissue (HP:0009025)2.35728714
52Hypertensive crisis (HP:0100735)2.32329413
53Thoracic kyphosis (HP:0002942)2.31336692
54Pointed chin (HP:0000307)2.30413809
55Retinal dysplasia (HP:0007973)2.30397547
56Anomalous pulmonary venous return (HP:0010772)2.29010854
57Renovascular hypertension (HP:0100817)2.28293401
58Metaphyseal cupping (HP:0003021)2.24291436
59Upper limb amyotrophy (HP:0009129)2.22698231
60Distal upper limb amyotrophy (HP:0007149)2.22698231
61Obstructive lung disease (HP:0006536)2.21316870
62Chronic obstructive pulmonary disease (HP:0006510)2.21316870
63Urinary urgency (HP:0000012)2.20133929
64Abnormality of the corticospinal tract (HP:0002492)2.18568601
65Increased cerebral lipofuscin (HP:0011813)2.15990922
66Ragged-red muscle fibers (HP:0003200)2.15763627
67Distal lower limb amyotrophy (HP:0008944)2.13978049
68Gastrointestinal inflammation (HP:0004386)2.13927514
69Testicular atrophy (HP:0000029)2.13622596
70Spinal rigidity (HP:0003306)2.13103909
71Long palpebral fissure (HP:0000637)2.12923364
72Facial hemangioma (HP:0000329)2.12531910
73Lissencephaly (HP:0001339)2.11347792
74Abnormality of the fingertips (HP:0001211)2.10835188
75Occipital encephalocele (HP:0002085)2.10593276
76Truncus arteriosus (HP:0001660)2.10494187
77Severe visual impairment (HP:0001141)2.08966333
78Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.08536025
79Joint stiffness (HP:0001387)2.08353632
80Turricephaly (HP:0000262)2.07523284
81Centrally nucleated skeletal muscle fibers (HP:0003687)2.06533522
82Abnormal gallbladder physiology (HP:0012438)2.06504869
83Cholecystitis (HP:0001082)2.06504869
84Termporal pattern (HP:0011008)2.05895826
85Insidious onset (HP:0003587)2.05895826
86Basal cell carcinoma (HP:0002671)2.05472791
87Increased neuronal autofluorescent lipopigment (HP:0002074)2.05276616
88Cerebral aneurysm (HP:0004944)2.04640108
89Mediastinal lymphadenopathy (HP:0100721)2.03979347
90Seborrheic dermatitis (HP:0001051)2.03540014
91Scanning speech (HP:0002168)2.03183347
92Neoplasm of the oral cavity (HP:0100649)2.02524699
93Neoplasm of the heart (HP:0100544)2.01910708
94Deformed sella turcica (HP:0002681)2.00131894
95Patellar dislocation (HP:0002999)1.99854187
96Abnormality of polysaccharide metabolism (HP:0011012)1.99056478
97Abnormality of glycosaminoglycan metabolism (HP:0004371)1.99056478
98Abnormality of mucopolysaccharide metabolism (HP:0011020)1.99056478
99Premature skin wrinkling (HP:0100678)1.98893966
100Inflammation of the large intestine (HP:0002037)1.97827249
101Mucopolysacchariduria (HP:0008155)1.97065722
102Urinary glycosaminoglycan excretion (HP:0003541)1.97065722
103Meningocele (HP:0002435)1.96634769
104Tented upper lip vermilion (HP:0010804)1.95479039
105Abnormality of the distal phalanges of the toes (HP:0010182)1.94694902
106Hypoplasia of the thymus (HP:0000778)1.93846661
107Recurrent abscess formation (HP:0002722)1.91056160
108Poikiloderma (HP:0001029)1.90536366
109Abnormal delayed hypersensitivity skin test (HP:0002963)1.90491653
110Atelectasis (HP:0100750)1.89700904
111Slow saccadic eye movements (HP:0000514)1.89406363
112Selective tooth agenesis (HP:0001592)1.88745614
113Dislocated radial head (HP:0003083)1.88085665
114Ankle clonus (HP:0011448)1.87851370
115Increased IgE level (HP:0003212)1.87343112
116Spastic paraplegia (HP:0001258)1.87298870
117Abnormality of the columella (HP:0009929)1.86812351
118Shallow orbits (HP:0000586)1.86709902
119Hypoplasia of the capital femoral epiphysis (HP:0003090)1.86665015
120Impaired vibration sensation in the lower limbs (HP:0002166)1.86413897
121Hypertriglyceridemia (HP:0002155)1.86304495
122Squamous cell carcinoma (HP:0002860)1.86193977
123Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.86120703
124Mitral regurgitation (HP:0001653)1.86035295
125Hypopigmentation of the fundus (HP:0007894)1.85299222
126T lymphocytopenia (HP:0005403)1.84333273
127Bowel diverticulosis (HP:0005222)1.84162750
128Short nail (HP:0001799)1.84039083
129Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.83865894
130Loss of speech (HP:0002371)1.83737970
131Easy fatigability (HP:0003388)1.82691423
132Abnormality of the pulmonary veins (HP:0011718)1.82473874
133Achilles tendon contracture (HP:0001771)1.82116701
134Bowed forearm bones (HP:0003956)1.81838508
135Bowing of the arm (HP:0006488)1.81838508
136Spina bifida occulta (HP:0003298)1.80856436
137Recurrent fungal infections (HP:0002841)1.80810734
138Elfin facies (HP:0004428)1.80790090
139Abnormality of the distal phalanx of the thumb (HP:0009617)1.80045158
140Spastic tetraparesis (HP:0001285)1.78799471
141Flattened epiphyses (HP:0003071)1.78712082
142Flat acetabular roof (HP:0003180)1.78613233
143Abnormality of the radial head (HP:0003995)1.78497986
144Nasal polyposis (HP:0100582)1.78049812
145Congenital glaucoma (HP:0001087)1.77831814
146Hyperthyroidism (HP:0000836)1.77321657
147Tongue fasciculations (HP:0001308)1.76393541
148Colon cancer (HP:0003003)1.76307306
149Muscular dystrophy (HP:0003560)1.76239184
150Distal lower limb muscle weakness (HP:0009053)1.75793550
151Degeneration of the lateral corticospinal tracts (HP:0002314)1.75084090
152Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.75084090
153Polygenic inheritance (HP:0010982)1.74322771
154CNS hypomyelination (HP:0003429)1.74183784
155Reticulocytosis (HP:0001923)1.74013152
156Disproportionate tall stature (HP:0001519)1.73906260
157Lymphangioma (HP:0100764)1.73897802
158Rough bone trabeculation (HP:0100670)1.73599667
159Paraplegia (HP:0010550)1.72615713
160Pathologic fracture (HP:0002756)1.72547490
161Epidermoid cyst (HP:0200040)1.72426617
162Abnormality of the motor neurons (HP:0002450)1.72424582
163Abnormal neuron morphology (HP:0012757)1.72424582
164Abnormality of the Achilles tendon (HP:0005109)1.72373827
165Recurrent bacterial skin infections (HP:0005406)1.71350335
166Pustule (HP:0200039)1.71301411
167Microretrognathia (HP:0000308)1.70722733
168Increased nuchal translucency (HP:0010880)1.70559482
169Recurrent viral infections (HP:0004429)1.70516737
170Gastrointestinal dysmotility (HP:0002579)1.70444845
171Fatigue (HP:0012378)1.69913382
172Gingivitis (HP:0000230)1.69867363
173Thin ribs (HP:0000883)1.69362810
174Non-midline cleft lip (HP:0100335)1.68916925
175Hepatitis (HP:0012115)1.66994260
176Viral hepatitis (HP:0006562)1.66087428
177Myopathic facies (HP:0002058)1.65902473
178Poor suck (HP:0002033)1.65482511
179Focal motor seizures (HP:0011153)1.65457435
180Trigonocephaly (HP:0000243)1.64842435
181Stridor (HP:0010307)1.62157839

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K3.77162764
2SMG13.66067216
3BUB13.27767925
4MAP4K13.18964788
5PRPF4B2.78755003
6CSNK1A1L2.68304427
7TRIB32.56617256
8STK162.55912221
9NME22.44249938
10MAP3K102.17350068
11PKN22.10909745
12SIK11.98592065
13CSNK1G31.89700940
14SCYL21.88720293
15IRAK31.88486990
16ICK1.85551312
17BLK1.77158260
18CSF1R1.77021784
19EPHA21.72712095
20UHMK11.72335136
21PRKD21.68780030
22EPHB11.68265709
23TAOK11.56996522
24FES1.55812025
25CLK11.53650085
26TNK21.53186286
27ERN11.50461747
28GRK61.48219363
29CSNK1G21.46738328
30ITK1.46220598
31PAK21.44521539
32CDK121.43297041
33SIK21.42596907
34STK101.42512114
35CDC71.38468674
36RAF11.37065283
37MARK21.30122290
38CSNK1G11.29440808
39ALK1.29185501
40PIM21.24089004
41CAMKK11.21337719
42FGFR41.20960249
43FLT31.18067823
44PASK1.18026696
45RIPK11.14654713
46MAP3K71.14493255
47MST1R1.13487102
48PAK61.12960023
49TSSK61.12371042
50RPS6KL11.11699952
51RPS6KC11.11699952
52IRAK41.10446536
53MAPK151.09313412
54RPS6KA21.06165537
55TBK11.06121650
56BTK1.05548223
57TAOK21.03029106
58PDGFRA1.02834633
59CDK41.02363284
60MAP3K61.00606229
61MAP3K30.95434116
62TESK10.92631244
63SIK30.92470018
64RPS6KA60.91651105
65MAP3K10.90959069
66HIPK20.90699359
67TTN0.88656524
68MAP2K20.88344176
69MAPKAPK50.87459061
70BMX0.87135422
71MTOR0.86541196
72PNCK0.86533565
73BRD40.85009094
74TYRO30.81550949
75IRAK20.80994988
76PDPK10.80766104
77CDK190.80522410
78RIPK40.80042506
79TYK20.79153870
80DYRK1B0.78023676
81KIT0.77367642
82DAPK10.77108228
83PRKD30.76946115
84CHEK10.74916363
85HCK0.73426517
86MAP2K30.71796520
87CDC42BPA0.71061017
88AURKA0.70771285
89TLK10.69860056
90PRKCH0.69129974
91CSNK1D0.68767023
92MAP3K80.67613957
93LRRK20.66448448
94NEK20.64655276
95KDR0.64473548
96MAPK120.63186785
97CAMK1G0.62217455
98FGFR10.61532723
99CDK150.61445496
100LMTK20.61311146
101CDK11A0.60518284
102TRPM70.60408689
103ZAP700.58425367
104CDK50.58386607
105JAK30.58174458
106CDK180.57783890
107MAP3K110.56933310
108MAPK40.56309723
109ATR0.56168089
110MAP2K40.55626971
111PTK20.54561045
112LCK0.54384882
113SYK0.54323513
114BRAF0.54156193
115BCKDK0.53912851
116TESK20.51613520
117MARK30.51215354
118NTRK20.50781741
119RPS6KA10.49013106
120MAPK110.48431915
121CCNB10.47432916
122MATK0.46904514
123ARAF0.45148767
124AKT20.45008964
125PTK60.44575782
126FGFR20.44135591
127RET0.43882149
128JAK10.43516186
129MAPKAPK30.43336827
130MAP2K60.42733594
131TGFBR20.42039890
132CDK20.42031747
133CDK140.42020035
134JAK20.41882402
135KSR10.41358175
136PDK10.39136550
137RPS6KB20.38209239
138PRKD10.38100543
139PIM10.37733037
140CDK70.37520079
141KSR20.36980996
142PAK40.36697428
143CDK90.36392952
144PRKCI0.35739001
145MAPK70.35403251
146MAP3K130.35163198
147PRKAA10.34984987
148ABL10.34889151
149CSK0.34587193
150VRK20.33927693
151MAPKAPK20.33921839
152ABL20.33420282
153PRKG20.32032156
154RPS6KA40.31219635
155MAPK80.28837066
156CDK60.28327639
157STK380.27857715

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005113.40125670
2DNA replication_Homo sapiens_hsa030303.22139136
3Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.99976034
4Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.93112588
5Other types of O-glycan biosynthesis_Homo sapiens_hsa005142.91547775
6Glycosaminoglycan degradation_Homo sapiens_hsa005312.29799714
7Primary immunodeficiency_Homo sapiens_hsa053402.29331957
8Selenocompound metabolism_Homo sapiens_hsa004502.11603152
9Homologous recombination_Homo sapiens_hsa034402.08941809
10Vitamin B6 metabolism_Homo sapiens_hsa007501.93823761
11Fructose and mannose metabolism_Homo sapiens_hsa000511.84114739
12Base excision repair_Homo sapiens_hsa034101.76021582
13One carbon pool by folate_Homo sapiens_hsa006701.75062193
14Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.74600686
15Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.73548869
16Pentose phosphate pathway_Homo sapiens_hsa000301.66312484
17Mismatch repair_Homo sapiens_hsa034301.59467216
18Sulfur relay system_Homo sapiens_hsa041221.58976681
19Spliceosome_Homo sapiens_hsa030401.58864402
20Biosynthesis of amino acids_Homo sapiens_hsa012301.58401398
21B cell receptor signaling pathway_Homo sapiens_hsa046621.54530426
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.49682884
23Bladder cancer_Homo sapiens_hsa052191.48628754
24Osteoclast differentiation_Homo sapiens_hsa043801.40384923
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.38612267
26Galactose metabolism_Homo sapiens_hsa000521.37230028
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.31385228
28N-Glycan biosynthesis_Homo sapiens_hsa005101.30975371
29Colorectal cancer_Homo sapiens_hsa052101.26955011
30Systemic lupus erythematosus_Homo sapiens_hsa053221.26468998
31Chronic myeloid leukemia_Homo sapiens_hsa052201.24252560
32Steroid biosynthesis_Homo sapiens_hsa001001.23506896
33Cell cycle_Homo sapiens_hsa041101.21658531
34Central carbon metabolism in cancer_Homo sapiens_hsa052301.21175465
35RNA transport_Homo sapiens_hsa030131.19116545
36Acute myeloid leukemia_Homo sapiens_hsa052211.18766601
37Fatty acid metabolism_Homo sapiens_hsa012121.14755958
38Alcoholism_Homo sapiens_hsa050341.11304247
39T cell receptor signaling pathway_Homo sapiens_hsa046601.09637745
40RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.08938505
41Fatty acid biosynthesis_Homo sapiens_hsa000611.08585278
42Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.07481589
43Non-homologous end-joining_Homo sapiens_hsa034501.04304424
44Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.03828880
45Toll-like receptor signaling pathway_Homo sapiens_hsa046201.00472552
46Lysine degradation_Homo sapiens_hsa003101.00308857
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.97815701
48Inositol phosphate metabolism_Homo sapiens_hsa005620.97807353
49Leishmaniasis_Homo sapiens_hsa051400.96897919
50mRNA surveillance pathway_Homo sapiens_hsa030150.96546939
51Cyanoamino acid metabolism_Homo sapiens_hsa004600.95182014
52Apoptosis_Homo sapiens_hsa042100.95133758
53Hepatitis B_Homo sapiens_hsa051610.94998373
54Glutamatergic synapse_Homo sapiens_hsa047240.94399987
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.94192909
56Insulin signaling pathway_Homo sapiens_hsa049100.92754487
57Lysosome_Homo sapiens_hsa041420.92185538
58Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.91317367
59Hepatitis C_Homo sapiens_hsa051600.91183781
60Endocytosis_Homo sapiens_hsa041440.91037625
61Herpes simplex infection_Homo sapiens_hsa051680.90867451
62Endometrial cancer_Homo sapiens_hsa052130.90540258
63Phosphatidylinositol signaling system_Homo sapiens_hsa040700.90446075
64Non-small cell lung cancer_Homo sapiens_hsa052230.88379253
65Viral carcinogenesis_Homo sapiens_hsa052030.87593603
66Choline metabolism in cancer_Homo sapiens_hsa052310.87215855
67Fanconi anemia pathway_Homo sapiens_hsa034600.84939279
68ABC transporters_Homo sapiens_hsa020100.84667140
69Shigellosis_Homo sapiens_hsa051310.83239415
70VEGF signaling pathway_Homo sapiens_hsa043700.82263121
71Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.82111897
72Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.81855029
73Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.81216712
74Fatty acid degradation_Homo sapiens_hsa000710.79256256
75Pyruvate metabolism_Homo sapiens_hsa006200.78809394
76Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.78650288
77Pyrimidine metabolism_Homo sapiens_hsa002400.78602315
78Leukocyte transendothelial migration_Homo sapiens_hsa046700.77524063
79mTOR signaling pathway_Homo sapiens_hsa041500.76704985
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.76497771
81Epstein-Barr virus infection_Homo sapiens_hsa051690.76322808
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.75972917
83GnRH signaling pathway_Homo sapiens_hsa049120.75247806
84Prolactin signaling pathway_Homo sapiens_hsa049170.72752342
85Toxoplasmosis_Homo sapiens_hsa051450.72693885
86Dorso-ventral axis formation_Homo sapiens_hsa043200.72184661
87Circadian entrainment_Homo sapiens_hsa047130.72082184
88Rap1 signaling pathway_Homo sapiens_hsa040150.70329382
89HTLV-I infection_Homo sapiens_hsa051660.69799763
90Sphingolipid signaling pathway_Homo sapiens_hsa040710.69359256
91Tuberculosis_Homo sapiens_hsa051520.69078174
92Oocyte meiosis_Homo sapiens_hsa041140.68491325
93TNF signaling pathway_Homo sapiens_hsa046680.68028586
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.67881502
95Influenza A_Homo sapiens_hsa051640.67784643
96Carbon metabolism_Homo sapiens_hsa012000.67157429
97Thyroid cancer_Homo sapiens_hsa052160.67135805
98Gap junction_Homo sapiens_hsa045400.66658172
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.66281175
100NF-kappa B signaling pathway_Homo sapiens_hsa040640.66187506
101Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66002834
102Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65332770
103AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.65110449
104Morphine addiction_Homo sapiens_hsa050320.64933043
105AMPK signaling pathway_Homo sapiens_hsa041520.64282113
106Arginine biosynthesis_Homo sapiens_hsa002200.64229899
107Long-term depression_Homo sapiens_hsa047300.63475506
108Renal cell carcinoma_Homo sapiens_hsa052110.63132482
109Folate biosynthesis_Homo sapiens_hsa007900.62995828
110Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.62959867
111Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.62496783
112Prostate cancer_Homo sapiens_hsa052150.62129622
113Drug metabolism - other enzymes_Homo sapiens_hsa009830.61811227
114Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61496670
115Regulation of autophagy_Homo sapiens_hsa041400.60941973
116Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60322663
117Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.58157633
118Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.58018512
119MAPK signaling pathway_Homo sapiens_hsa040100.57623839
120Propanoate metabolism_Homo sapiens_hsa006400.56307675
121Small cell lung cancer_Homo sapiens_hsa052220.56233705
122Estrogen signaling pathway_Homo sapiens_hsa049150.55199376
123Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.54877010
124Glycerophospholipid metabolism_Homo sapiens_hsa005640.53673320
125Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.52724182
126Viral myocarditis_Homo sapiens_hsa054160.52031400
127Bile secretion_Homo sapiens_hsa049760.51619018
128Basal cell carcinoma_Homo sapiens_hsa052170.50780290
129Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50534502
130Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50507589
131MicroRNAs in cancer_Homo sapiens_hsa052060.50204841
132Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50166090
133Chemokine signaling pathway_Homo sapiens_hsa040620.49890704
134Platelet activation_Homo sapiens_hsa046110.49110231
135Glioma_Homo sapiens_hsa052140.48757480
136Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.47844349
137Prion diseases_Homo sapiens_hsa050200.47780113
138Neurotrophin signaling pathway_Homo sapiens_hsa047220.47038403
139Measles_Homo sapiens_hsa051620.46947890
140Purine metabolism_Homo sapiens_hsa002300.45945355
141Notch signaling pathway_Homo sapiens_hsa043300.45449778
142ErbB signaling pathway_Homo sapiens_hsa040120.44760163
143Pancreatic cancer_Homo sapiens_hsa052120.44209767
144HIF-1 signaling pathway_Homo sapiens_hsa040660.43909807
145Insulin resistance_Homo sapiens_hsa049310.43317789
146Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.42995472
147Salmonella infection_Homo sapiens_hsa051320.40592018
148Melanogenesis_Homo sapiens_hsa049160.39409453

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