BPIFC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of skin barrier (GO:0061436)9.81709887
2regulation of water loss via skin (GO:0033561)8.44121414
3keratinization (GO:0031424)8.27149469
4gap junction assembly (GO:0016264)7.65814807
5detection of bacterium (GO:0016045)6.69548531
6detection of other organism (GO:0098543)6.12564966
7hair cycle (GO:0042633)6.10389364
8molting cycle (GO:0042303)6.10389364
9polarized epithelial cell differentiation (GO:0030859)5.61648831
10keratinocyte differentiation (GO:0030216)5.52375771
11multicellular organismal water homeostasis (GO:0050891)5.49590900
12linoleic acid metabolic process (GO:0043651)5.25959007
13sphingoid metabolic process (GO:0046519)5.21101809
14phosphatidylserine acyl-chain remodeling (GO:0036150)5.12723670
15endothelium development (GO:0003158)5.10288151
16lateral sprouting from an epithelium (GO:0060601)5.04376563
17skin morphogenesis (GO:0043589)4.99721124
18regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.87104847
19atrial cardiac muscle cell action potential (GO:0086014)4.72863227
20regulation of glomerular filtration (GO:0003093)4.61834605
21negative regulation of heart growth (GO:0061117)4.60665904
22negative regulation of cardiac muscle tissue growth (GO:0055022)4.60665904
23purine ribonucleotide transport (GO:0015868)4.58158164
24establishment of planar polarity (GO:0001736)4.58066197
25establishment of tissue polarity (GO:0007164)4.58066197
26adenine nucleotide transport (GO:0051503)4.56532079
27skeletal muscle tissue regeneration (GO:0043403)4.55524804
28glucosamine-containing compound catabolic process (GO:1901072)4.54924012
29sphingosine metabolic process (GO:0006670)4.51403505
30water homeostasis (GO:0030104)4.45609874
31intermediate filament cytoskeleton organization (GO:0045104)4.39188643
32phosphatidylethanolamine acyl-chain remodeling (GO:0036152)4.38369563
33peptide cross-linking (GO:0018149)4.36325778
34intestinal epithelial cell development (GO:0060576)4.36111157
35epidermal cell differentiation (GO:0009913)4.26242253
36epithelial cell maturation (GO:0002070)4.20822771
37regulation of cell proliferation involved in kidney development (GO:1901722)4.16609098
38regulation of tight junction assembly (GO:2000810)4.11978215
39phosphatidylglycerol acyl-chain remodeling (GO:0036148)4.08907240
40keratinocyte proliferation (GO:0043616)4.05473276
41phosphatidylcholine acyl-chain remodeling (GO:0036151)4.02547443
42long-chain fatty acid biosynthetic process (GO:0042759)4.00270338
43imidazole-containing compound metabolic process (GO:0052803)3.99405279
44lipoxygenase pathway (GO:0019372)3.96846435
45epithelial cell differentiation involved in prostate gland development (GO:0060742)3.95927154
46regulation of neuron projection regeneration (GO:0070570)3.95524524
47regulation of axon regeneration (GO:0048679)3.95524524
48diol metabolic process (GO:0034311)3.93135155
49hair follicle morphogenesis (GO:0031069)3.90327001
50epidermis development (GO:0008544)3.80065292
51detection of external biotic stimulus (GO:0098581)3.76948973
52positive regulation of interleukin-8 secretion (GO:2000484)3.75349049
53G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.72891462
54regulation of keratinocyte differentiation (GO:0045616)3.67574220
55intermediate filament organization (GO:0045109)3.66234733
56regulation of transforming growth factor beta1 production (GO:0032908)3.63429390
57negative regulation of keratinocyte proliferation (GO:0010839)3.61698582
58purine nucleotide transport (GO:0015865)3.50674562
59regulation of interleukin-8 secretion (GO:2000482)3.49356838
60regulation of natural killer cell differentiation (GO:0032823)3.49243553
61bundle of His cell to Purkinje myocyte communication (GO:0086069)3.46679547
62regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.35002168
63cellular response to arsenic-containing substance (GO:0071243)3.32284815
64negative regulation of stress fiber assembly (GO:0051497)3.30738102
65renal system process involved in regulation of blood volume (GO:0001977)3.30733420
66ceramide biosynthetic process (GO:0046513)3.29875339
67epithelium development (GO:0060429)3.27486323
68regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.27182401
69one-carbon compound transport (GO:0019755)3.26323804
70regulation of ruffle assembly (GO:1900027)3.25715306
71regulation of cholesterol homeostasis (GO:2000188)3.24675048
72regulation of chemokine secretion (GO:0090196)3.24549206
73cyclooxygenase pathway (GO:0019371)3.21750278
74detection of biotic stimulus (GO:0009595)3.18330444
75regulation of hypersensitivity (GO:0002883)3.17331322
76magnesium ion transport (GO:0015693)3.14336402
77molting cycle process (GO:0022404)3.12630031
78hair cycle process (GO:0022405)3.12630031
79phospholipid catabolic process (GO:0009395)3.12142112
80chronic inflammatory response (GO:0002544)3.09992122
81keratinocyte development (GO:0003334)3.09120502
82polyol transport (GO:0015791)3.09056603
83phosphatidylserine metabolic process (GO:0006658)3.01168222
84regulation of somitogenesis (GO:0014807)2.99778281
85response to UV-B (GO:0010224)2.98896649
86hemidesmosome assembly (GO:0031581)2.97471228
87regulation of phospholipase A2 activity (GO:0032429)2.92681184
88negative regulation of cardiac muscle tissue development (GO:0055026)2.90355177
89ectoderm development (GO:0007398)2.90132202
90superoxide anion generation (GO:0042554)2.89735412
91regulation of keratinocyte proliferation (GO:0010837)2.89130383
92phospholipid scrambling (GO:0017121)2.88526266
93positive regulation of interleukin-1 beta secretion (GO:0050718)2.88165043
94defense response to fungus (GO:0050832)2.87239351
95positive regulation of chemokine secretion (GO:0090197)2.86608612
96positive regulation of heat generation (GO:0031652)2.78968805
97CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.78446101
98T-helper cell differentiation (GO:0042093)2.78446101
99positive regulation of interleukin-1 beta production (GO:0032731)2.77336709
100amino sugar catabolic process (GO:0046348)2.76012112
101polyketide metabolic process (GO:0030638)2.74513009
102doxorubicin metabolic process (GO:0044598)2.74513009
103daunorubicin metabolic process (GO:0044597)2.74513009
104negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.72960890
105cell-cell junction assembly (GO:0007043)2.71388339
106nucleoside transport (GO:0015858)2.71343850
107regulation of epidermis development (GO:0045682)2.71028593
108genitalia morphogenesis (GO:0035112)2.70745043
109cardiac muscle cell action potential involved in contraction (GO:0086002)2.69907587
110positive regulation of glomerulus development (GO:0090193)2.69539924
111regulation of mitotic spindle checkpoint (GO:1903504)2.69186242
112regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.69186242
113negative regulation of T cell mediated immunity (GO:0002710)2.69082245
114negative regulation of epidermal cell differentiation (GO:0045605)2.68188841
115positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.67885346
116negative regulation of kidney development (GO:0090185)2.63909351
117negative regulation of actin filament bundle assembly (GO:0032232)2.63872812
118negative regulation of interleukin-17 production (GO:0032700)2.63857355
119cardiac muscle cell action potential (GO:0086001)2.63718264
120pyrimidine-containing compound transmembrane transport (GO:0072531)2.63157378
121positive regulation of interleukin-1 secretion (GO:0050716)2.61753493
122sympathetic nervous system development (GO:0048485)2.60981807
123definitive hemopoiesis (GO:0060216)2.59564090
124surfactant homeostasis (GO:0043129)2.57588860
125positive regulation of interleukin-10 production (GO:0032733)2.55640526
126phospholipid efflux (GO:0033700)2.54425229
127hair cell differentiation (GO:0035315)2.53610289
128hair follicle development (GO:0001942)2.53571097
129sphingolipid biosynthetic process (GO:0030148)2.53403731
130negative regulation of cell aging (GO:0090344)2.53167346
131dendritic cell migration (GO:0036336)2.52192047
132positive regulation of antigen processing and presentation (GO:0002579)2.52078302
133early endosome to late endosome transport (GO:0045022)2.51108667
134regulation of fever generation (GO:0031620)2.51097526
135positive regulation of cholesterol efflux (GO:0010875)2.50422247
136alditol phosphate metabolic process (GO:0052646)2.47435137
137regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.45398439
138negative regulation of interferon-gamma production (GO:0032689)2.45170024
139antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.45087120
140cellular response to calcium ion (GO:0071277)2.44991071
141negative regulation of mast cell activation (GO:0033004)2.43954599
142ceramide catabolic process (GO:0046514)2.43679676
143chemical homeostasis within a tissue (GO:0048875)2.42675576
144regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.42005588
145positive regulation of interleukin-1 production (GO:0032732)2.40424435
146phosphatidylinositol acyl-chain remodeling (GO:0036149)2.37427433
147energy homeostasis (GO:0097009)2.37379906
148regulation of interleukin-1 beta secretion (GO:0050706)2.36695329
149alpha-beta T cell differentiation involved in immune response (GO:0002293)2.36197882
150alpha-beta T cell activation involved in immune response (GO:0002287)2.36197882
151T cell differentiation involved in immune response (GO:0002292)2.36197882
152fatty acid elongation (GO:0030497)2.35182957
153CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.35132113
154DNA deamination (GO:0045006)2.33793478
155eyelid development in camera-type eye (GO:0061029)2.33746307
156gland morphogenesis (GO:0022612)2.32736735
157dendritic cell chemotaxis (GO:0002407)2.31803702
158G-protein coupled receptor internalization (GO:0002031)2.31451414
159positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.29342575
160L-fucose catabolic process (GO:0042355)2.29245596
161fucose catabolic process (GO:0019317)2.29245596
162L-fucose metabolic process (GO:0042354)2.29245596
163inflammatory response to antigenic stimulus (GO:0002437)2.27304489
164interleukin-1-mediated signaling pathway (GO:0070498)2.25321380
165facial nerve structural organization (GO:0021612)2.23756097
166intermediate filament-based process (GO:0045103)2.22202977
167desmosome organization (GO:0002934)10.0357470

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.16925555
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.98761231
3BP1_19119308_ChIP-ChIP_Hs578T_Human2.65420941
4TP63_19390658_ChIP-ChIP_HaCaT_Human2.45330817
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.39875983
6PCGF2_27294783_Chip-Seq_ESCs_Mouse2.38538168
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.34804464
8P63_26484246_Chip-Seq_KERATINOCYTES_Human2.20993295
9SUZ12_27294783_Chip-Seq_NPCs_Mouse2.19388592
10CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.13862952
11NFE2_27457419_Chip-Seq_LIVER_Mouse2.12385980
12E2F7_22180533_ChIP-Seq_HELA_Human2.09952195
13SOX9_24532713_ChIP-Seq_HFSC_Mouse2.09092912
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.08078606
15TP63_17297297_ChIP-ChIP_HaCaT_Human10.1954420
16IGF1R_20145208_ChIP-Seq_DFB_Human1.92514114
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.87518262
18TCF4_18268006_ChIP-ChIP_LS174T_Human1.86657399
19PCGF2_27294783_Chip-Seq_NPCs_Mouse1.85093185
20BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.82270541
21FOXO3_23340844_ChIP-Seq_DLD1_Human1.81275749
22NOTCH1_21737748_ChIP-Seq_TLL_Human1.80939795
23HIF1A_21447827_ChIP-Seq_MCF-7_Human1.79911010
24ZFP57_27257070_Chip-Seq_ESCs_Mouse1.78115244
25EZH2_27294783_Chip-Seq_NPCs_Mouse1.77776665
26SCL_19346495_ChIP-Seq_HPC-7_Human1.76679566
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.68144285
28PIAS1_25552417_ChIP-Seq_VCAP_Human1.66371323
29EGR1_19032775_ChIP-ChIP_M12_Human1.65771375
30GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.61637688
31BMI1_23680149_ChIP-Seq_NPCS_Mouse1.61468837
32NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.60668380
33NRF2_20460467_ChIP-Seq_MEFs_Mouse1.60668380
34SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.59947085
35AHR_22903824_ChIP-Seq_MCF-7_Human1.57358640
36CDX2_19796622_ChIP-Seq_MESCs_Mouse1.57350615
37FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.55310164
38FUS_26573619_Chip-Seq_HEK293_Human1.52472414
39IRF8_21731497_ChIP-ChIP_J774_Mouse1.52214216
40SUZ12_18555785_Chip-Seq_ESCs_Mouse1.48026114
41CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.47731171
42NANOG_18555785_Chip-Seq_ESCs_Mouse1.47264628
43TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.47028983
44STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.45559747
45STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.45020004
46SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.44720740
47SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.44720740
48ARNT_22903824_ChIP-Seq_MCF-7_Human1.44153997
49STAT3_18555785_Chip-Seq_ESCs_Mouse1.44087403
50EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.44024348
51GATA6_21074721_ChIP-Seq_CACO-2_Human1.43504805
52E2F1_18555785_Chip-Seq_ESCs_Mouse1.41942640
53LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41792760
54PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.40238082
55FOXM1_26456572_ChIP-Seq_MCF-7_Human1.40168288
56NMYC_18555785_Chip-Seq_ESCs_Mouse1.39525223
57CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.37123766
58TP53_18474530_ChIP-ChIP_U2OS_Human1.36945463
59ESR1_21235772_ChIP-Seq_MCF-7_Human1.36612897
60AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.36179829
61SMAD_19615063_ChIP-ChIP_OVARY_Human1.35341145
62ZNF217_24962896_ChIP-Seq_MCF-7_Human1.35230187
63FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.33974075
64P53_22387025_ChIP-Seq_ESCs_Mouse1.33308628
65IRF8_22096565_ChIP-ChIP_GC-B_Human1.32719845
66AR_21572438_ChIP-Seq_LNCaP_Human1.32024198
67OCT4_18555785_Chip-Seq_ESCs_Mouse1.31771010
68RXR_22108803_ChIP-Seq_LS180_Human1.30337139
69EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.27441144
70CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.26363689
71LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.25922961
72RNF2_27304074_Chip-Seq_NSC_Mouse1.24710870
73CJUN_26792858_Chip-Seq_BT549_Human1.24487765
74GATA3_24758297_ChIP-Seq_MCF-7_Human1.23790761
75CMYC_18555785_Chip-Seq_ESCs_Mouse1.23434280
76RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23315581
77PU1_27457419_Chip-Seq_LIVER_Mouse1.23188732
78ESR1_20079471_ChIP-ChIP_T-47D_Human1.22898532
79SMAD4_21799915_ChIP-Seq_A2780_Human1.22613179
80SOX2_18555785_Chip-Seq_ESCs_Mouse1.21492276
81ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.21360445
82RUNX1_27457419_Chip-Seq_LIVER_Mouse1.20507085
83ESRRB_18555785_Chip-Seq_ESCs_Mouse1.19915983
84ZFX_18555785_Chip-Seq_ESCs_Mouse1.19465668
85CTCF_18555785_Chip-Seq_ESCs_Mouse1.19186557
86HNFA_21074721_ChIP-Seq_CACO-2_Human1.19145321
87Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.18673358
88TP63_23658742_ChIP-Seq_EP156T_Human1.16771078
89TP63_22573176_ChIP-Seq_HFKS_Human1.16647729
90CDX2_22108803_ChIP-Seq_LS180_Human1.15345036
91RBPJ_21746931_ChIP-Seq_IB4_Human1.13730264
92CRX_20693478_ChIP-Seq_RETINA_Mouse1.13326255
93AR_25329375_ChIP-Seq_VCAP_Human1.12939945
94SMAD1_18555785_Chip-Seq_ESCs_Mouse1.12726048
95IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.12393424
96BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.11786668
97AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.11199051
98TCF4_22108803_ChIP-Seq_LS180_Human1.11177569
99POU3F2_20337985_ChIP-ChIP_501MEL_Human1.09998269
100SMAD3_21741376_ChIP-Seq_EPCs_Human1.09858255
101CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09167942
102P300_18555785_Chip-Seq_ESCs_Mouse1.08397785
103ETV1_20927104_ChIP-Seq_GIST48_Human1.06742526
104KLF4_18555785_Chip-Seq_ESCs_Mouse1.06307603
105EWS_26573619_Chip-Seq_HEK293_Human1.05394686
106FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.05277337
107SOX2_20726797_ChIP-Seq_SW620_Human1.04950644
108NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03970216
109PHF8_20622853_ChIP-Seq_HELA_Human1.02656545
110RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.02341095
111SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.02185860
112OCT4_21477851_ChIP-Seq_ESCs_Mouse1.01952036
113VDR_22108803_ChIP-Seq_LS180_Human1.01722814
114EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.00781024
115HTT_18923047_ChIP-ChIP_STHdh_Human1.00762879
116FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.99696252
117UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99003653
118ESR2_21235772_ChIP-Seq_MCF-7_Human0.98963233
119CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98287200
120P300_19829295_ChIP-Seq_ESCs_Human0.97477749
121MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97019763
122TP53_16413492_ChIP-PET_HCT116_Human0.96785206
123TAL1_26923725_Chip-Seq_HPCs_Mouse0.96777189
124KAP1_22055183_ChIP-Seq_ESCs_Mouse0.95572944
125TAF15_26573619_Chip-Seq_HEK293_Human0.95369042
126SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94146875
127GATA4_25053715_ChIP-Seq_YYC3_Human0.92171037
128IRF8_27001747_Chip-Seq_BMDM_Mouse0.92085138
129CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.91485452
130PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.91434604
131NFYB_21822215_ChIP-Seq_K562_Human0.90586916
132TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90065425
133POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.90065425
134RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.89863063
135CTBP2_25329375_ChIP-Seq_LNCAP_Human0.89814659
136KLF5_25053715_ChIP-Seq_YYC3_Human0.89532887
137PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.89295799
138CBX2_27304074_Chip-Seq_ESCs_Mouse0.88727102
139GATA2_21666600_ChIP-Seq_HMVEC_Human0.88588501
140P53_22127205_ChIP-Seq_FIBROBLAST_Human0.88461146
141SOX2_27498859_Chip-Seq_STOMACH_Mouse0.87770505
142TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.87225549
143P53_21459846_ChIP-Seq_SAOS-2_Human0.85256684
144PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.84792346
145TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.83782307
146ERG_20517297_ChIP-Seq_VCAP_Human0.83076344
147NCOR_22424771_ChIP-Seq_293T_Human0.82286886
148SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.80782881
149PPAR_26484153_Chip-Seq_NCI-H1993_Human0.80701095
150FOXA1_25552417_ChIP-Seq_VCAP_Human0.80615755
151NANOG_19829295_ChIP-Seq_ESCs_Human0.79544154
152SOX2_19829295_ChIP-Seq_ESCs_Human0.79544154
153GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.78066143
154PRDM14_20953172_ChIP-Seq_ESCs_Human0.77863817
155BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.77234378
156TAF2_19829295_ChIP-Seq_ESCs_Human0.76280138
157JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.74429161
158CEBPB_22108803_ChIP-Seq_LS180_Human0.74308190
159TBL1_22424771_ChIP-Seq_293T_Human0.74274972
160NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.74243232

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier6.36680424
2MP0003941_abnormal_skin_development4.57388220
3MP0005275_abnormal_skin_tensile4.56814166
4MP0005501_abnormal_skin_physiology4.12586830
5MP0000566_synostosis4.06425072
6MP0005451_abnormal_body_composition3.98498509
7MP0009379_abnormal_foot_pigmentation3.63621687
8MP0000579_abnormal_nail_morphology3.48488392
9MP0004381_abnormal_hair_follicle3.39171704
10MP0002098_abnormal_vibrissa_morphology3.02150870
11MP0002254_reproductive_system_inflammat3.00831587
12MP0010234_abnormal_vibrissa_follicle2.98634865
13MP0002060_abnormal_skin_morphology2.95711928
14MP0000383_abnormal_hair_follicle2.85404884
15MP0001216_abnormal_epidermal_layer2.83489291
16MP0001346_abnormal_lacrimal_gland2.63437882
17MP0010771_integument_phenotype2.59679848
18MP0002396_abnormal_hematopoietic_system2.39166389
19MP0004947_skin_inflammation2.36080971
20MP0010678_abnormal_skin_adnexa2.32959898
21MP0000647_abnormal_sebaceous_gland2.18734109
22MP0002277_abnormal_respiratory_mucosa2.15605521
23MP0000377_abnormal_hair_follicle2.07963480
24MP0000427_abnormal_hair_cycle1.91330495
25MP0009384_cardiac_valve_regurgitation1.84456822
26MP0003191_abnormal_cellular_cholesterol1.81768406
27MP0004885_abnormal_endolymph1.79363706
28MP0005257_abnormal_intraocular_pressure1.75152998
29MP0003878_abnormal_ear_physiology1.74310890
30MP0005377_hearing/vestibular/ear_phenot1.74310890
31MP0001191_abnormal_skin_condition1.58239054
32MP0004782_abnormal_surfactant_physiolog1.57819394
33MP0009931_abnormal_skin_appearance1.53883489
34MP0003453_abnormal_keratinocyte_physiol1.52423092
35MP0001188_hyperpigmentation1.46595030
36MP0006292_abnormal_olfactory_placode1.40830880
37MP0002095_abnormal_skin_pigmentation1.36801518
38MP0003011_delayed_dark_adaptation1.35003999
39MP0002009_preneoplasia1.32260861
40MP0000762_abnormal_tongue_morphology1.28972518
41MP0004185_abnormal_adipocyte_glucose1.28257376
42MP0003763_abnormal_thymus_physiology1.28214809
43MP0000367_abnormal_coat/_hair1.25994810
44MP0002148_abnormal_hypersensitivity_rea1.25729931
45MP0005075_abnormal_melanosome_morpholog1.21976213
46MP0000467_abnormal_esophagus_morphology1.20310586
47MP0001835_abnormal_antigen_presentation1.20198885
48MP0002163_abnormal_gland_morphology1.14625645
49MP0001851_eye_inflammation1.13496008
50MP0000015_abnormal_ear_pigmentation1.12509941
51MP0001243_abnormal_dermal_layer1.07001798
52MP0001542_abnormal_bone_strength1.04827450
53MP0005409_darkened_coat_color1.00708999
54MP0003693_abnormal_embryo_hatching0.99137461
55MP0001986_abnormal_taste_sensitivity0.95962173
56MP0001984_abnormal_olfaction0.95400033
57MP0001784_abnormal_fluid_regulation0.95069271
58MP0000465_gastrointestinal_hemorrhage0.93632340
59MP0003436_decreased_susceptibility_to0.93400374
60MP0003705_abnormal_hypodermis_morpholog0.92385547
61MP0003279_aneurysm0.90203911
62MP0002102_abnormal_ear_morphology0.84035055
63MP0005174_abnormal_tail_pigmentation0.82842666
64MP0008004_abnormal_stomach_pH0.82619183
65MP0010094_abnormal_chromosome_stability0.81859486
66MP0010352_gastrointestinal_tract_polyps0.81507011
67MP0003136_yellow_coat_color0.79202134
68MP0000627_abnormal_mammary_gland0.77815389
69MP0002006_tumorigenesis0.75848236
70MP0000569_abnormal_digit_pigmentation0.75219444
71MP0000490_abnormal_crypts_of0.74825302
72MP0000613_abnormal_salivary_gland0.74221718
73MP0009250_abnormal_appendicular_skeleto0.74211532
74MP0005379_endocrine/exocrine_gland_phen0.73720934
75MP0002177_abnormal_outer_ear0.72460796
76MP0003950_abnormal_plasma_membrane0.72413410
77MP0002249_abnormal_larynx_morphology0.71350983
78MP0000428_abnormal_craniofacial_morphol0.69213267
79MP0005387_immune_system_phenotype0.69194941
80MP0001790_abnormal_immune_system0.69194941
81MP0008058_abnormal_DNA_repair0.68969608
82MP0001800_abnormal_humoral_immune0.68762273
83MP0003111_abnormal_nucleus_morphology0.68336341
84MP0000750_abnormal_muscle_regeneration0.67868786
85MP0005025_abnormal_response_to0.67828961
86MP0005397_hematopoietic_system_phenotyp0.66753223
87MP0001545_abnormal_hematopoietic_system0.66753223
88MP0005503_abnormal_tendon_morphology0.65909393
89MP0009053_abnormal_anal_canal0.65893444
90MP0009785_altered_susceptibility_to0.65001313
91MP0002452_abnormal_antigen_presenting0.64550934
92MP0002420_abnormal_adaptive_immunity0.64135517
93MP0001819_abnormal_immune_cell0.64044328
94MP0001853_heart_inflammation0.64026076
95MP0008057_abnormal_DNA_replication0.63867708
96MP0000372_irregular_coat_pigmentation0.63807066
97MP0002419_abnormal_innate_immunity0.63156921
98MP0008007_abnormal_cellular_replicative0.62870620
99MP0005000_abnormal_immune_tolerance0.62713212
100MP0002723_abnormal_immune_serum0.62069317
101MP0005310_abnormal_salivary_gland0.61691025
102MP0003724_increased_susceptibility_to0.61360223
103MP0005671_abnormal_response_to0.60852521
104MP0003566_abnormal_cell_adhesion0.59843483
105MP0003690_abnormal_glial_cell0.57412631
106MP0004808_abnormal_hematopoietic_stem0.56702714
107MP0003828_pulmonary_edema0.55581761
108MP0009764_decreased_sensitivity_to0.55383228
109MP0003183_abnormal_peptide_metabolism0.54911783
110MP0009672_abnormal_birth_weight0.54876574
111MP0004264_abnormal_extraembryonic_tissu0.54071455
112MP0000462_abnormal_digestive_system0.53830185
113MP0000858_altered_metastatic_potential0.53429842
114MP0001340_abnormal_eyelid_morphology0.53026742
115MP0002109_abnormal_limb_morphology0.51936179
116MP0002132_abnormal_respiratory_system0.51797088
117MP0001119_abnormal_female_reproductive0.51779589
118MP0002877_abnormal_melanocyte_morpholog0.51637912
119MP0001873_stomach_inflammation0.51550649
120MP0005645_abnormal_hypothalamus_physiol0.51230878
121MP0005390_skeleton_phenotype0.50705108
122MP0001919_abnormal_reproductive_system0.50480275
123MP0004215_abnormal_myocardial_fiber0.49682644
124MP0000470_abnormal_stomach_morphology0.49340648
125MP0003718_maternal_effect0.48869955
126MP0005023_abnormal_wound_healing0.44848663
127MP0005197_abnormal_uvea_morphology0.44248608
128MP0008789_abnormal_olfactory_epithelium0.43616227
129MP0002233_abnormal_nose_morphology0.43006558
130MP0003638_abnormal_response/metabolism_0.36357362
131MP0009780_abnormal_chondrocyte_physiolo0.34375422
132MP0001440_abnormal_grooming_behavior0.34270928
133MP0005171_absent_coat_pigmentation0.34121577
134MP0004484_altered_response_of0.33422652
135MP0002138_abnormal_hepatobiliary_system0.32852004
136MP0005394_taste/olfaction_phenotype0.31870697
137MP0005499_abnormal_olfactory_system0.31870697
138MP0005508_abnormal_skeleton_morphology0.29576174
139MP0001177_atelectasis0.27734874
140MP0002234_abnormal_pharynx_morphology0.26845696
141MP0002090_abnormal_vision0.26474154
142MP0004510_myositis0.25774799
143MP0005388_respiratory_system_phenotype0.24921344
144MP0002133_abnormal_respiratory_system0.24921344
145MP0008569_lethality_at_weaning0.24843670
146MP0009046_muscle_twitch0.23843322
147MP0002092_abnormal_eye_morphology0.23680218
148MP0001299_abnormal_eye_distance/0.22850557
149MP0004197_abnormal_fetal_growth/weight/0.22432436
150MP0000432_abnormal_head_morphology0.22291730
151MP0002638_abnormal_pupillary_reflex0.21446352
152MP0003755_abnormal_palate_morphology0.20870661
153MP0005193_abnormal_anterior_eye0.20564725
154MP0001186_pigmentation_phenotype0.20106836

Predicted human phenotypes

RankGene SetZ-score
1Increased IgE level (HP:0003212)5.79074021
2Hypotrichosis (HP:0001006)5.35637683
3Congenital ichthyosiform erythroderma (HP:0007431)5.08826975
4Parakeratosis (HP:0001036)5.02133886
5Lip pit (HP:0100267)5.00044131
6Erythema (HP:0010783)4.94031391
7Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.91844360
8Abnormality of nail color (HP:0100643)4.69681592
9Woolly hair (HP:0002224)4.63645502
10Erythroderma (HP:0001019)4.52673309
11Ectropion (HP:0000656)4.34228578
12Aplasia involving bones of the extremities (HP:0009825)4.32323682
13Aplasia involving bones of the upper limbs (HP:0009823)4.32323682
14Aplasia of the phalanges of the hand (HP:0009802)4.32323682
15Selective tooth agenesis (HP:0001592)4.28427981
16Conjunctival hamartoma (HP:0100780)4.27738337
17Palmoplantar hyperkeratosis (HP:0000972)4.22151149
18Plantar hyperkeratosis (HP:0007556)4.17050830
19Palmar hyperkeratosis (HP:0010765)4.12981047
20Absent eyelashes (HP:0000561)4.01481179
21Onycholysis (HP:0001806)3.84686510
22Short middle phalanx of the 5th finger (HP:0004220)3.65377673
23Gangrene (HP:0100758)3.39742536
24Prostate neoplasm (HP:0100787)3.39457339
25Right ventricular cardiomyopathy (HP:0011663)3.38764216
26Absent hair (HP:0002298)3.30876134
27Chromsome breakage (HP:0040012)3.25681466
28Corneal erosion (HP:0200020)3.23310426
29Abnormality of permanent molar morphology (HP:0011071)3.22891068
30Abnormality of the dental root (HP:0006486)3.22891068
31Taurodontia (HP:0000679)3.22891068
32Sparse eyelashes (HP:0000653)3.20523408
33Sparse scalp hair (HP:0002209)3.18287727
34Eczematoid dermatitis (HP:0000976)3.17903429
35Chromosomal breakage induced by crosslinking agents (HP:0003221)3.16100922
36Long nose (HP:0003189)3.15889978
37Pili torti (HP:0003777)3.04936029
38Tetraparesis (HP:0002273)3.04378153
39Abnormality of molar (HP:0011077)3.03371791
40Abnormality of molar morphology (HP:0011070)3.03371791
41Pruritus (HP:0000989)3.01890733
42Hypohidrosis (HP:0000966)2.99016834
43Hypoplastic labia majora (HP:0000059)2.98807522
44Abnormality of the dental pulp (HP:0006479)2.89870671
45Hamartoma of the eye (HP:0010568)2.83182916
46Distal lower limb muscle weakness (HP:0009053)2.81511812
47Thick nail (HP:0001805)2.80648783
48Curly hair (HP:0002212)2.73436424
49Abnormality of the labia majora (HP:0012881)2.70988223
50Abnormality of the salivary glands (HP:0010286)2.70902527
51Split foot (HP:0001839)2.70006073
52Aplasia cutis congenita (HP:0001057)2.68118208
53Natal tooth (HP:0000695)2.64025853
54Fragile nails (HP:0001808)2.58200082
55Abnormality of the preputium (HP:0100587)2.52610431
56Nasolacrimal duct obstruction (HP:0000579)2.52046996
57Nail dystrophy (HP:0008404)2.44868357
58Abnormal blistering of the skin (HP:0008066)2.44708556
59Abnormality of secondary sexual hair (HP:0009888)2.37439082
60Abnormality of the axillary hair (HP:0100134)2.37439082
61Milia (HP:0001056)2.30545492
62Dry hair (HP:0011359)2.28404326
63Alopecia of scalp (HP:0002293)2.26452831
64Congenital, generalized hypertrichosis (HP:0004540)2.26012349
65Blepharitis (HP:0000498)2.25959040
66Broad alveolar ridges (HP:0000187)2.24804550
67Popliteal pterygium (HP:0009756)2.23864056
68Septate vagina (HP:0001153)2.23471876
69Follicular hyperkeratosis (HP:0007502)2.19999931
70Depressed nasal tip (HP:0000437)2.16212141
71Abnormality of the prostate (HP:0008775)2.15256755
72Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.14372653
73Abnormality of the parietal bone (HP:0002696)2.13851252
74Abnormality of incisor morphology (HP:0011063)2.13008852
75Furrowed tongue (HP:0000221)2.12783476
76Atrioventricular block (HP:0001678)2.11648148
77Palmoplantar keratoderma (HP:0000982)2.10881330
78Myositis (HP:0100614)2.10024975
79Mixed hearing impairment (HP:0000410)2.07073237
80Abnormality of the lacrimal duct (HP:0011481)2.06388369
81Abnormal hair laboratory examination (HP:0003328)2.05618120
82Fine hair (HP:0002213)2.05361904
83Ventricular tachycardia (HP:0004756)2.04940288
84Lack of skin elasticity (HP:0100679)2.04616493
85Melanocytic nevus (HP:0000995)2.03189046
86Anhidrosis (HP:0000970)2.02421297
87Corneal dystrophy (HP:0001131)2.01088844
88Reticulocytopenia (HP:0001896)2.00441596
89Advanced eruption of teeth (HP:0006288)2.00109887
90Conical tooth (HP:0000698)1.99361904
91Patchy hypopigmentation of hair (HP:0011365)1.98707333
92White forelock (HP:0002211)1.97663526
93Abnormality of hair growth rate (HP:0011363)1.97080956
94Slow-growing hair (HP:0002217)1.97080956
95Ectopic kidney (HP:0000086)1.95716422
96Xerostomia (HP:0000217)1.95626699
97Recurrent abscess formation (HP:0002722)1.95514776
98Hamartoma (HP:0010566)1.95291613
99Abnormality of the nasolacrimal system (HP:0000614)1.93544853
100Septo-optic dysplasia (HP:0100842)1.91188025
101Alveolar cell carcinoma (HP:0006519)1.91067812
102Non-midline cleft lip (HP:0100335)1.91065989
103Premature loss of primary teeth (HP:0006323)1.89765898
104Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.89623519
105Oligodontia (HP:0000677)1.89186202
106Clubbing of toes (HP:0100760)1.88670620
107Recurrent pneumonia (HP:0006532)1.86135081
108Amelogenesis imperfecta (HP:0000705)1.85605355
109Hypergammaglobulinemia (HP:0010702)1.85539401
110Sensory axonal neuropathy (HP:0003390)1.84448879
111Optic neuritis (HP:0100653)1.81768743
112Retrobulbar optic neuritis (HP:0100654)1.81768743
113Cheilitis (HP:0100825)1.81728528
114Malignant hyperthermia (HP:0002047)1.81126695
115Dry skin (HP:0000958)1.80983974
116Pustule (HP:0200039)1.79525669
117Labial hypoplasia (HP:0000066)1.78023303
118Recurrent bacterial skin infections (HP:0005406)1.77588080
119Sepsis (HP:0100806)1.76272724
120Dehydration (HP:0001944)1.75986314
121Hyperhidrosis (HP:0000975)1.74281264
122Craniofacial hyperostosis (HP:0004493)1.73952389
123Narrow nasal bridge (HP:0000446)1.73478312
124Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.73074128
125Orchitis (HP:0100796)1.72630680
126Chronic otitis media (HP:0000389)1.72157309
127Short hallux (HP:0010109)1.71849647
128Amniotic constriction ring (HP:0009775)1.70746616
129Abnormality of placental membranes (HP:0011409)1.70746616
130Areflexia of lower limbs (HP:0002522)1.70235001
131Abnormality of DNA repair (HP:0003254)1.69897319
132Oral leukoplakia (HP:0002745)1.69259041
133Unilateral renal agenesis (HP:0000122)1.68797165
134Acute myeloid leukemia (HP:0004808)1.67881882
135Skin ulcer (HP:0200042)1.66987282
136Breast hypoplasia (HP:0003187)1.66462468
137Hypoplastic left heart (HP:0004383)1.65767867
138Keratoconjunctivitis (HP:0001096)1.65553685
139Brittle hair (HP:0002299)1.65462308
140Abnormality of the columella (HP:0009929)1.64677911
141Neoplasm of the tracheobronchial system (HP:0100552)1.64569338
142Autoamputation (HP:0001218)1.63082029
143Large eyes (HP:0001090)1.62665505
144Abnormality of the fingertips (HP:0001211)1.61717972
145Absent rod-and cone-mediated responses on ERG (HP:0007688)1.59843468
146Abnormality of the nasal septum (HP:0000419)1.59388242
147Duplicated collecting system (HP:0000081)1.57330372
148Ulnar claw (HP:0001178)1.56902227
149Abnormality of the renal collecting system (HP:0004742)1.54671037
150Keratitis (HP:0000491)1.54504954
151Keratoconjunctivitis sicca (HP:0001097)1.54202537

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR14.88761595
2FRK4.51530114
3MAPKAPK33.82646689
4MAPK73.41027395
5CDK83.03172641
6MAPK123.00923472
7MST42.92828811
8IRAK32.69431797
9LATS12.65998830
10IRAK42.37304074
11SIK32.29451163
12MAP3K22.24335428
13TEC2.20050651
14FGFR12.13901795
15ZAK2.11269703
16MST1R1.99312135
17PLK41.90939796
18TRPM71.85934543
19MAP3K141.85579663
20PIM21.84722988
21TXK1.75920084
22RPS6KB21.74351917
23EIF2AK21.70898213
24MAP3K61.67737154
25FGFR21.60336651
26PRKCE1.59852770
27SRPK11.57194670
28BLK1.51958384
29CASK1.49894842
30INSRR1.39062371
31MAP3K91.39045324
32TAOK31.37720976
33MUSK1.35726449
34BRD41.32522636
35TNIK1.30531408
36MAPKAPK51.28768354
37VRK11.28292937
38STK38L1.26381928
39DMPK1.22444914
40NUAK11.21289247
41SGK2231.21252043
42SGK4941.21252043
43ERBB31.21095627
44MAP3K31.20781588
45CDK31.18863201
46CDK71.17355770
47GRK71.15362575
48IKBKB1.13599626
49PIK3CG1.13577227
50ADRBK21.11721627
51KIT1.11094517
52GRK11.10704561
53TGFBR21.09231864
54BMPR21.08642694
55CDK121.03883474
56PRKCG1.03852649
57FGFR31.02742992
58EPHB21.00495094
59BMPR1B1.00432630
60NLK0.99510109
61BCR0.98195091
62RPS6KB10.97329065
63MAP2K60.97150648
64MOS0.94082214
65TAF10.92414074
66STK100.92060012
67STK240.89745468
68MAP3K120.89461217
69BTK0.89045360
70YES10.87887051
71MKNK20.86575845
72MKNK10.85378923
73STK160.84925839
74CHEK20.84094732
75CHUK0.84041172
76RIPK40.83947500
77STK30.81967167
78ITK0.79588551
79MAPKAPK20.78689114
80IKBKE0.78170314
81BRSK20.77353711
82NTRK20.76627310
83FER0.76020883
84ADRBK10.74737712
85CLK10.73284695
86EEF2K0.72621234
87IRAK10.72206351
88PIM10.71247607
89SYK0.70842080
90SGK30.69869302
91RPS6KA40.69113268
92NME20.68752143
93TIE10.67227716
94WNK10.65803831
95TESK10.65446524
96JAK30.64797163
97AURKB0.64120094
98TTK0.63342546
99MAP2K30.61372962
100TNK20.60171824
101ATR0.59434149
102PLK20.59310601
103TAOK10.59253380
104ERBB40.58241965
105IRAK20.58006218
106MARK30.51599024
107MAP3K10.51557606
108MAPK150.50677326
109MAPK130.50424141
110MINK10.50262203
111PKN10.49150221
112MAP2K70.48311093
113CSNK1D0.48189691
114CDC70.48180147
115MAP3K50.47923411
116DYRK30.47092737
117EPHA20.46816218
118SGK10.45793641
119PRKAA20.45476497
120CDK190.44442699
121MAP4K10.44375905
122LYN0.44258137
123CAMKK20.43898002
124MAP3K70.43312541
125HCK0.41442446
126MAP2K40.41005862
127TLK10.40227843
128MAPK110.39574946
129EPHA30.39290307
130MAPK40.39117682
131IGF1R0.39040492
132SGK20.38561320
133CDK60.38373216
134ATM0.38223159
135AKT30.37934863
136PDK20.37117185
137ILK0.37055554
138STK40.36587053
139MET0.33246625
140GSK3A0.32266526
141MAPK90.32094231
142MTOR0.29541443
143ABL10.29237836
144STK110.28387554
145LRRK20.22792326
146TRIM280.22228776
147GRK50.21919333
148PDGFRB0.20813488
149ACVR1B0.20352805
150MAPK100.20319099
151MAPK80.18603086
152GRK60.17382909
153CAMK1G0.17133512
154EPHA40.13065943
155CSNK1A1L0.12553985
156RIPK10.12461620

Predicted pathways (KEGG)

RankGene SetZ-score
1Sphingolipid metabolism_Homo sapiens_hsa006002.54403766
2Dorso-ventral axis formation_Homo sapiens_hsa043202.30439953
3Homologous recombination_Homo sapiens_hsa034402.13790181
4Basal transcription factors_Homo sapiens_hsa030222.09063148
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.06634919
6Arachidonic acid metabolism_Homo sapiens_hsa005902.05052550
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.97938107
8Linoleic acid metabolism_Homo sapiens_hsa005911.84462745
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.81244214
10Fanconi anemia pathway_Homo sapiens_hsa034601.80970300
11Ribosome_Homo sapiens_hsa030101.78389206
12Long-term depression_Homo sapiens_hsa047301.78214895
13GnRH signaling pathway_Homo sapiens_hsa049121.71798019
14Hematopoietic cell lineage_Homo sapiens_hsa046401.60651089
15p53 signaling pathway_Homo sapiens_hsa041151.60393498
16Renin secretion_Homo sapiens_hsa049241.58484580
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.57704946
18NF-kappa B signaling pathway_Homo sapiens_hsa040641.55339474
19DNA replication_Homo sapiens_hsa030301.53925570
20Herpes simplex infection_Homo sapiens_hsa051681.53585865
21Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.48245026
22NOD-like receptor signaling pathway_Homo sapiens_hsa046211.47913015
23Primary immunodeficiency_Homo sapiens_hsa053401.47683925
24Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.46141948
25Glycerophospholipid metabolism_Homo sapiens_hsa005641.43926016
26VEGF signaling pathway_Homo sapiens_hsa043701.37729857
27Jak-STAT signaling pathway_Homo sapiens_hsa046301.36283060
28Vascular smooth muscle contraction_Homo sapiens_hsa042701.34662378
29Choline metabolism in cancer_Homo sapiens_hsa052311.32756378
30Ether lipid metabolism_Homo sapiens_hsa005651.29102365
31Non-homologous end-joining_Homo sapiens_hsa034501.24526507
32Leishmaniasis_Homo sapiens_hsa051401.23054595
33Intestinal immune network for IgA production_Homo sapiens_hsa046721.22969652
34Measles_Homo sapiens_hsa051621.21277555
35Toll-like receptor signaling pathway_Homo sapiens_hsa046201.21082676
36SNARE interactions in vesicular transport_Homo sapiens_hsa041301.16600103
37Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.16580248
38Base excision repair_Homo sapiens_hsa034101.16487390
39RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.15821619
40Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.15144821
41Transcriptional misregulation in cancer_Homo sapiens_hsa052021.13394480
42Osteoclast differentiation_Homo sapiens_hsa043801.10792334
43Glutamatergic synapse_Homo sapiens_hsa047241.09960320
44Amoebiasis_Homo sapiens_hsa051461.08620446
45Phosphatidylinositol signaling system_Homo sapiens_hsa040701.07888689
46RNA degradation_Homo sapiens_hsa030181.06958027
47Mismatch repair_Homo sapiens_hsa034301.05567944
48Pertussis_Homo sapiens_hsa051331.04330020
49Cyanoamino acid metabolism_Homo sapiens_hsa004601.03042436
50Autoimmune thyroid disease_Homo sapiens_hsa053201.02326492
51TNF signaling pathway_Homo sapiens_hsa046680.98757486
52Staphylococcus aureus infection_Homo sapiens_hsa051500.97860777
53Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.97275935
54Influenza A_Homo sapiens_hsa051640.95949716
55Graft-versus-host disease_Homo sapiens_hsa053320.94636842
56Rheumatoid arthritis_Homo sapiens_hsa053230.94521403
57Phototransduction_Homo sapiens_hsa047440.93501627
58Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.93429846
59Cell cycle_Homo sapiens_hsa041100.91368543
60Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.89703740
61Collecting duct acid secretion_Homo sapiens_hsa049660.89425879
62Ovarian steroidogenesis_Homo sapiens_hsa049130.88323730
63Fatty acid elongation_Homo sapiens_hsa000620.87049044
64Nitrogen metabolism_Homo sapiens_hsa009100.85510619
65Tuberculosis_Homo sapiens_hsa051520.83536386
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.83277071
67Allograft rejection_Homo sapiens_hsa053300.82824063
68Oxytocin signaling pathway_Homo sapiens_hsa049210.81939558
69Acute myeloid leukemia_Homo sapiens_hsa052210.80772996
70Hedgehog signaling pathway_Homo sapiens_hsa043400.80433166
71Nucleotide excision repair_Homo sapiens_hsa034200.79830700
72Circadian rhythm_Homo sapiens_hsa047100.79484365
73Malaria_Homo sapiens_hsa051440.78940646
74Pancreatic secretion_Homo sapiens_hsa049720.78129533
75Melanogenesis_Homo sapiens_hsa049160.77121794
76Spliceosome_Homo sapiens_hsa030400.76776985
77Melanoma_Homo sapiens_hsa052180.76353955
78Vitamin digestion and absorption_Homo sapiens_hsa049770.75810855
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.74669114
80MicroRNAs in cancer_Homo sapiens_hsa052060.73595782
81Retinol metabolism_Homo sapiens_hsa008300.73494734
82ABC transporters_Homo sapiens_hsa020100.72806590
83Inositol phosphate metabolism_Homo sapiens_hsa005620.71385101
84Gastric acid secretion_Homo sapiens_hsa049710.70868242
85Basal cell carcinoma_Homo sapiens_hsa052170.69818516
86Apoptosis_Homo sapiens_hsa042100.69775295
87Hepatitis C_Homo sapiens_hsa051600.69399735
88Toxoplasmosis_Homo sapiens_hsa051450.69145708
89Circadian entrainment_Homo sapiens_hsa047130.69028407
90Hepatitis B_Homo sapiens_hsa051610.68798436
91Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.68736182
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.68493130
93Legionellosis_Homo sapiens_hsa051340.66984271
94HTLV-I infection_Homo sapiens_hsa051660.66697759
95Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.66548658
96RNA polymerase_Homo sapiens_hsa030200.66242861
97Ras signaling pathway_Homo sapiens_hsa040140.65015396
98Small cell lung cancer_Homo sapiens_hsa052220.64395810
99Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63880246
100Thyroid cancer_Homo sapiens_hsa052160.63869411
101Dopaminergic synapse_Homo sapiens_hsa047280.63824487
102Histidine metabolism_Homo sapiens_hsa003400.63619078
103Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.62656243
104TGF-beta signaling pathway_Homo sapiens_hsa043500.62530025
105Amphetamine addiction_Homo sapiens_hsa050310.61882236
106Gap junction_Homo sapiens_hsa045400.61601786
107Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.61027829
108Leukocyte transendothelial migration_Homo sapiens_hsa046700.60482402
109Tight junction_Homo sapiens_hsa045300.60379967
110MAPK signaling pathway_Homo sapiens_hsa040100.59190441
111Estrogen signaling pathway_Homo sapiens_hsa049150.58785657
112Adherens junction_Homo sapiens_hsa045200.58494646
113Pancreatic cancer_Homo sapiens_hsa052120.58320580
114Sphingolipid signaling pathway_Homo sapiens_hsa040710.58244701
115Regulation of autophagy_Homo sapiens_hsa041400.57063984
116Notch signaling pathway_Homo sapiens_hsa043300.56367908
117Salivary secretion_Homo sapiens_hsa049700.56178641
118Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.55665621
119Platelet activation_Homo sapiens_hsa046110.54587400
120Long-term potentiation_Homo sapiens_hsa047200.54331568
121B cell receptor signaling pathway_Homo sapiens_hsa046620.53933181
122Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53436813
123Other glycan degradation_Homo sapiens_hsa005110.52004844
124Endocytosis_Homo sapiens_hsa041440.51821595
125Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50818522
126Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49694326
127Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48222528
128Serotonergic synapse_Homo sapiens_hsa047260.48006295
129Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.47935809
130Pyrimidine metabolism_Homo sapiens_hsa002400.47471239
131Wnt signaling pathway_Homo sapiens_hsa043100.47298122
132Olfactory transduction_Homo sapiens_hsa047400.45805687
133Rap1 signaling pathway_Homo sapiens_hsa040150.44872264
134Phenylalanine metabolism_Homo sapiens_hsa003600.44492792
135ECM-receptor interaction_Homo sapiens_hsa045120.44339095
136Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.44308904
137Prolactin signaling pathway_Homo sapiens_hsa049170.44300123
138Prostate cancer_Homo sapiens_hsa052150.44115808
139Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.44052547
140Hippo signaling pathway_Homo sapiens_hsa043900.43969468
141Mineral absorption_Homo sapiens_hsa049780.43907339
142Glioma_Homo sapiens_hsa052140.43669508
143Steroid hormone biosynthesis_Homo sapiens_hsa001400.42172796
144Primary bile acid biosynthesis_Homo sapiens_hsa001200.41866366
145Chemokine signaling pathway_Homo sapiens_hsa040620.41834306
146Fat digestion and absorption_Homo sapiens_hsa049750.41208115
147FoxO signaling pathway_Homo sapiens_hsa040680.37933484
148cAMP signaling pathway_Homo sapiens_hsa040240.37385142
149Renal cell carcinoma_Homo sapiens_hsa052110.36084081
150beta-Alanine metabolism_Homo sapiens_hsa004100.35415199
151Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.33953842
152cGMP-PKG signaling pathway_Homo sapiens_hsa040220.32956755
153Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.32769682
154Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.32306727
155Aldosterone synthesis and secretion_Homo sapiens_hsa049250.30917741
156Protein digestion and absorption_Homo sapiens_hsa049740.30370376
157Calcium signaling pathway_Homo sapiens_hsa040200.29935349
158Renin-angiotensin system_Homo sapiens_hsa046140.29912282
159PPAR signaling pathway_Homo sapiens_hsa033200.28671441
160Glycerolipid metabolism_Homo sapiens_hsa005610.27178586
161Axon guidance_Homo sapiens_hsa043600.25174779
162Glucagon signaling pathway_Homo sapiens_hsa049220.25158761
163ErbB signaling pathway_Homo sapiens_hsa040120.24780477

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