BPIFB4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to cilium (GO:0061512)8.09067172
2one-carbon compound transport (GO:0019755)5.81240880
3positive regulation of digestive system process (GO:0060456)5.70351174
4tachykinin receptor signaling pathway (GO:0007217)5.50899307
5ethanol oxidation (GO:0006069)5.45630579
6antibacterial humoral response (GO:0019731)5.24990927
7regulation of cholesterol biosynthetic process (GO:0045540)5.21474071
8antimicrobial humoral response (GO:0019730)4.86433004
9cellular glucuronidation (GO:0052695)4.67330091
10uronic acid metabolic process (GO:0006063)4.64282919
11glucuronate metabolic process (GO:0019585)4.64282919
12activation of protein kinase A activity (GO:0034199)4.45439998
13adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)4.42953623
14regulation of sodium ion transmembrane transport (GO:1902305)4.39520207
15epoxygenase P450 pathway (GO:0019373)4.29361307
16ethanol metabolic process (GO:0006067)4.21816270
17lateral ventricle development (GO:0021670)4.11600597
18mating behavior (GO:0007617)3.85209034
19regulation of sodium ion transmembrane transporter activity (GO:2000649)3.79412436
20protein insertion into membrane (GO:0051205)3.79176825
21flavonoid metabolic process (GO:0009812)3.76124987
22gas transport (GO:0015669)3.70332208
23exogenous drug catabolic process (GO:0042738)3.63136992
24negative regulation of cytosolic calcium ion concentration (GO:0051481)3.51565007
25regulation of sodium ion transport (GO:0002028)3.49696055
26renal absorption (GO:0070293)3.42465852
27membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.39990175
28membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.39723108
29regulation of cholesterol metabolic process (GO:0090181)3.32906114
30negative regulation of astrocyte differentiation (GO:0048712)3.30208555
31cAMP biosynthetic process (GO:0006171)3.30139578
32water-soluble vitamin biosynthetic process (GO:0042364)3.27608017
33hormone catabolic process (GO:0042447)3.26402628
34regulation of heart rate by cardiac conduction (GO:0086091)3.24232492
35positive regulation of hormone biosynthetic process (GO:0046886)3.23125356
36cellular potassium ion homeostasis (GO:0030007)3.16508677
37alkaloid metabolic process (GO:0009820)3.12575967
38water transport (GO:0006833)3.08977980
39negative regulation of microtubule polymerization (GO:0031115)3.05675393
40drug catabolic process (GO:0042737)3.04466992
41sensory perception of smell (GO:0007608)24.6736138
42relaxation of cardiac muscle (GO:0055119)2.99827777
43cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.99759030
44membrane repolarization during action potential (GO:0086011)2.96553907
45omega-hydroxylase P450 pathway (GO:0097267)2.91941124
46cardiac conduction (GO:0061337)2.89010572
47layer formation in cerebral cortex (GO:0021819)2.87507842
48negative regulation of lipase activity (GO:0060192)2.86700823
49camera-type eye morphogenesis (GO:0048593)2.86037492
50ovulation cycle (GO:0042698)2.83253954
51toxin metabolic process (GO:0009404)2.78261107
52protein localization to endosome (GO:0036010)2.76814793
53response to vitamin A (GO:0033189)2.76349427
54potassium ion homeostasis (GO:0055075)2.71356153
55regulation of cardioblast proliferation (GO:0003264)2.70593006
56regulation of secondary heart field cardioblast proliferation (GO:0003266)2.70593006
57fluid transport (GO:0042044)2.69668932
58chemical homeostasis within a tissue (GO:0048875)2.69604199
59dopamine receptor signaling pathway (GO:0007212)2.68908485
60cellular copper ion homeostasis (GO:0006878)2.68011168
61regulation of steroid hormone biosynthetic process (GO:0090030)2.67353262
62negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.65590358
63primary alcohol catabolic process (GO:0034310)2.64769857
64sulfur amino acid catabolic process (GO:0000098)2.61731744
65regulation of cilium movement (GO:0003352)2.60644732
66L-ascorbic acid metabolic process (GO:0019852)2.58825052
67positive regulation of steroid biosynthetic process (GO:0010893)2.58753380
68sodium ion export (GO:0071436)2.58277830
69negative regulation of sodium ion transport (GO:0010766)2.56965397
70calcium-mediated signaling using intracellular calcium source (GO:0035584)2.51961548
71ectoderm development (GO:0007398)2.51934432
72cell communication involved in cardiac conduction (GO:0086065)2.49405182
73response to caffeine (GO:0031000)2.47369771
74cellular response to glucagon stimulus (GO:0071377)2.46259660
75cilium morphogenesis (GO:0060271)2.45938694
76peptide biosynthetic process (GO:0043043)2.44616216
77endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.43622114
78positive regulation of hormone metabolic process (GO:0032352)2.40605545
79atrial cardiac muscle cell action potential (GO:0086014)2.38713541
80axonal fasciculation (GO:0007413)2.36430683
81forebrain neuron development (GO:0021884)2.35162015
82glutamate secretion (GO:0014047)2.32246021
83establishment of apical/basal cell polarity (GO:0035089)2.30783368
84semaphorin-plexin signaling pathway (GO:0071526)2.26735916
85cAMP metabolic process (GO:0046058)2.26217681
86positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.24631833
87neuron cell-cell adhesion (GO:0007158)2.21164476
88negative regulation of immunoglobulin mediated immune response (GO:0002890)2.20662880
89negative regulation of B cell mediated immunity (GO:0002713)2.20662880
90positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.20399118
91behavioral response to cocaine (GO:0048148)2.18419930
92cellular response to electrical stimulus (GO:0071257)2.17547357
93response to follicle-stimulating hormone (GO:0032354)2.17524924
94innate immune response in mucosa (GO:0002227)2.16831973
95carnitine metabolic process (GO:0009437)2.16614553
96epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.15976025
97multicellular organismal water homeostasis (GO:0050891)2.15433054
98CDP-diacylglycerol biosynthetic process (GO:0016024)2.14526235
99chemosensory behavior (GO:0007635)13.7009578
100sensory perception of chemical stimulus (GO:0007606)13.3222856

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.94342566
2TRIM28_21343339_ChIP-Seq_HEK293_Human2.92346310
3ZNF263_19887448_ChIP-Seq_K562_Human2.72076578
4ERG_21242973_ChIP-ChIP_JURKAT_Human2.38157577
5CLOCK_20551151_ChIP-Seq_293T_Human2.07735149
6BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.97075118
7* DROSHA_22980978_ChIP-Seq_HELA_Human1.95702672
8LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.85916461
9EZH2_22144423_ChIP-Seq_EOC_Human1.85252978
10EZH2_18974828_ChIP-Seq_MESCs_Mouse1.77960456
11RNF2_18974828_ChIP-Seq_MESCs_Mouse1.77960456
12ESR2_21235772_ChIP-Seq_MCF-7_Human1.77288877
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.76086636
14LXR_22158963_ChIP-Seq_LIVER_Mouse1.69862553
15KDM2B_26808549_Chip-Seq_K562_Human1.66608230
16EED_16625203_ChIP-ChIP_MESCs_Mouse1.62788396
17SOX2_27498859_Chip-Seq_STOMACH_Mouse1.61716084
18ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.57778548
19RXR_22158963_ChIP-Seq_LIVER_Mouse1.57030852
20MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.56273168
21ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.54985796
22KDM2B_26808549_Chip-Seq_SUP-B15_Human1.50209280
23IKZF1_21737484_ChIP-ChIP_HCT116_Human1.49592862
24SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.46623379
25ZNF217_24962896_ChIP-Seq_MCF-7_Human1.45696694
26TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.45448340
27SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.42150092
28TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.40983450
29STAT6_21828071_ChIP-Seq_BEAS2B_Human1.40551362
30ETV2_25802403_ChIP-Seq_MESCs_Mouse1.37675780
31SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.37565118
32AHR_22903824_ChIP-Seq_MCF-7_Human1.35328624
33MTF2_20144788_ChIP-Seq_MESCs_Mouse1.35086998
34ESR1_20079471_ChIP-ChIP_T-47D_Human1.34107958
35SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.33962590
36TAF15_26573619_Chip-Seq_HEK293_Human1.32740237
37SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.32156145
38RUNX1_27514584_Chip-Seq_MCF-7_Human1.30510918
39GATA3_24758297_ChIP-Seq_MCF-7_Human1.28355595
40EP300_21415370_ChIP-Seq_HL-1_Mouse1.28196572
41ZFP281_18757296_ChIP-ChIP_E14_Mouse1.26282191
42NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.23519958
43WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.23373252
44RARB_27405468_Chip-Seq_BRAIN_Mouse1.22239213
45FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.21044590
46ERG_20517297_ChIP-Seq_VCAP_Human1.20580117
47AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.20457555
48RING1B_27294783_Chip-Seq_NPCs_Mouse1.20329899
49GATA3_27048872_Chip-Seq_THYMUS_Human1.19823250
50FOXO3_23340844_ChIP-Seq_DLD1_Human1.19139563
51P300_27058665_Chip-Seq_ZR-75-30cells_Human1.18100605
52RARG_19884340_ChIP-ChIP_MEFs_Mouse1.17600842
53SUZ12_27294783_Chip-Seq_ESCs_Mouse1.15068112
54JARID2_20075857_ChIP-Seq_MESCs_Mouse1.12901267
55ARNT_22903824_ChIP-Seq_MCF-7_Human1.10146228
56RING1B_27294783_Chip-Seq_ESCs_Mouse1.10123844
57LXR_22292898_ChIP-Seq_THP-1_Human1.08855245
58JARID2_20064375_ChIP-Seq_MESCs_Mouse1.07853122
59WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06047694
60ISL1_27105846_Chip-Seq_CPCs_Mouse1.05460512
61SMAD4_21741376_ChIP-Seq_HESCs_Human1.05447264
62MYC_19915707_ChIP-ChIP_AK7_Human1.05327685
63DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.03850780
64SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.02763963
65FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.02654845
66ATF3_27146783_Chip-Seq_COLON_Human1.02577830
67CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.00705404
68PIAS1_25552417_ChIP-Seq_VCAP_Human1.00238564
69ZFP281_27345836_Chip-Seq_ESCs_Mouse0.99879148
70KDM2B_26808549_Chip-Seq_JURKAT_Human0.99633051
71PPARA_22158963_ChIP-Seq_LIVER_Mouse0.99168945
72EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.99152878
73SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97419547
74RACK7_27058665_Chip-Seq_MCF-7_Human0.97418680
75RNF2_27304074_Chip-Seq_ESCs_Mouse0.97330637
76FOXM1_26456572_ChIP-Seq_MCF-7_Human0.97099438
77NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.96518485
78KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.96250245
79FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95820091
80ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.93902525
81KLF5_25053715_ChIP-Seq_YYC3_Human0.92898835
82GATA1_22025678_ChIP-Seq_K562_Human0.92559253
83GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.92398922
84FOXA2_19822575_ChIP-Seq_HepG2_Human0.92269688
85TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.91858004
86ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91204659
87RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.88883237
88CTCF_27219007_Chip-Seq_Bcells_Human0.88855325
89SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.88844579
90GATA1_19941827_ChIP-Seq_MEL86_Mouse0.88529938
91EZH2_27294783_Chip-Seq_ESCs_Mouse0.87662779
92ELK4_26923725_Chip-Seq_MESODERM_Mouse0.87011769
93KDM2B_26808549_Chip-Seq_DND41_Human0.86601657
94EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.86566769
95GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.84136472
96ESR1_21235772_ChIP-Seq_MCF-7_Human0.83459011
97NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.83342612
98ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.82741940
99STAT1_20625510_ChIP-Seq_HELA_Human0.81857236
100DPY_21335234_ChIP-Seq_ESCs_Mouse0.81114122

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005394_taste/olfaction_phenotype6.56145238
2MP0005499_abnormal_olfactory_system6.56145238
3MP0008875_abnormal_xenobiotic_pharmacok5.43596784
4MP0008789_abnormal_olfactory_epithelium5.13747220
5MP0003806_abnormal_nucleotide_metabolis2.38382100
6MP0010234_abnormal_vibrissa_follicle2.02098366
7MP0001984_abnormal_olfaction13.7432056
8MP0010030_abnormal_orbit_morphology1.76762689
9MP0002233_abnormal_nose_morphology1.54844512
10MP0002909_abnormal_adrenal_gland1.40083247
11MP0005365_abnormal_bile_salt1.39437910
12MP0002139_abnormal_hepatobiliary_system1.34001193
13MP0001485_abnormal_pinna_reflex1.31823665
14MP0001346_abnormal_lacrimal_gland1.21549910
15MP0005623_abnormal_meninges_morphology1.16729149
16MP0002653_abnormal_ependyma_morphology1.13984039
17MP0002822_catalepsy1.11203561
18MP0003329_amyloid_beta_deposits1.09186337
19MP0003075_altered_response_to1.00171287
20MP0002184_abnormal_innervation0.98712625
21MP0003566_abnormal_cell_adhesion0.90781871
22MP0004859_abnormal_synaptic_plasticity0.89835044
23MP0004858_abnormal_nervous_system0.89751362
24MP0000613_abnormal_salivary_gland0.88376034
25MP0010329_abnormal_lipoprotein_level0.88344394
26MP0004043_abnormal_pH_regulation0.86408206
27MP0000534_abnormal_ureter_morphology0.83399460
28MP0002896_abnormal_bone_mineralization0.80249541
29MP0000516_abnormal_urinary_system0.78650233
30MP0005367_renal/urinary_system_phenotyp0.78650233
31MP0000604_amyloidosis0.78136428
32MP0003635_abnormal_synaptic_transmissio0.76262614
33MP0005187_abnormal_penis_morphology0.74743714
34MP0002063_abnormal_learning/memory/cond0.74722247
35MP0005584_abnormal_enzyme/coenzyme_acti0.73273833
36MP0002877_abnormal_melanocyte_morpholog0.72896546
37MP0004270_analgesia0.71368253
38MP0001299_abnormal_eye_distance/0.65523167
39MP0005266_abnormal_metabolism0.64982376
40MP0003942_abnormal_urinary_system0.63962239
41MP0002752_abnormal_somatic_nervous0.62556022
42MP0005058_abnormal_lysosome_morphology0.61862776
43MP0009780_abnormal_chondrocyte_physiolo0.61047777
44MP0000465_gastrointestinal_hemorrhage0.59054695
45MP0006054_spinal_hemorrhage0.58946517
46MP0002882_abnormal_neuron_morphology0.58770359
47MP0003303_peritoneal_inflammation0.58605338
48MP0009745_abnormal_behavioral_response0.55992216
49MP0003633_abnormal_nervous_system0.55322419
50MP0002734_abnormal_mechanical_nocicepti0.54024642
51MP0003300_gastrointestinal_ulcer0.52297526
52MP0005248_abnormal_Harderian_gland0.51965344
53MP0001849_ear_inflammation0.51236074
54MP0004134_abnormal_chest_morphology0.51018643
55MP0004885_abnormal_endolymph0.49209007
56MP0003690_abnormal_glial_cell0.48511171
57MP0004085_abnormal_heartbeat0.48421857
58MP0001542_abnormal_bone_strength0.47797709
59MP0000778_abnormal_nervous_system0.45886600
60MP0008874_decreased_physiological_sensi0.45382247
61MP0002557_abnormal_social/conspecific_i0.45124793
62MP0001486_abnormal_startle_reflex0.44911838
63MP0000762_abnormal_tongue_morphology0.43958930
64MP0003283_abnormal_digestive_organ0.43775844
65MP0003195_calcinosis0.43694611
66MP0002064_seizures0.43561001
67MP0002272_abnormal_nervous_system0.43285679
68MP0002234_abnormal_pharynx_morphology0.43014602
69MP0005167_abnormal_blood-brain_barrier0.42664108
70MP0005508_abnormal_skeleton_morphology0.42572020
71MP0008961_abnormal_basal_metabolism0.40471091
72MP0003634_abnormal_glial_cell0.40109994
73MP0003705_abnormal_hypodermis_morpholog0.40026415
74MP0009643_abnormal_urine_homeostasis0.37961968
75MP0002837_dystrophic_cardiac_calcinosis0.37755991
76MP0003935_abnormal_craniofacial_develop0.37432911
77MP0002282_abnormal_trachea_morphology0.37136860
78MP0005410_abnormal_fertilization0.37101222
79MP0002152_abnormal_brain_morphology0.36989355
80MP0002092_abnormal_eye_morphology0.36539418
81MP0004811_abnormal_neuron_physiology0.36428951
82MP0002572_abnormal_emotion/affect_behav0.36332734
83MP0002295_abnormal_pulmonary_circulatio0.36231392
84MP0005360_urolithiasis0.36134688
85MP0003186_abnormal_redox_activity0.34518162
86MP0002118_abnormal_lipid_homeostasis0.33790576
87MP0005310_abnormal_salivary_gland0.33339466
88MP0004019_abnormal_vitamin_homeostasis0.32950978
89MP0003631_nervous_system_phenotype0.32597977
90MP0003252_abnormal_bile_duct0.32436515
91MP0000609_abnormal_liver_physiology0.32167102
92MP0003279_aneurysm0.31977649
93MP0000049_abnormal_middle_ear0.31121959
94MP0000631_abnormal_neuroendocrine_gland0.30229328
95MP0005377_hearing/vestibular/ear_phenot0.30059637
96MP0003878_abnormal_ear_physiology0.30059637
97MP0005645_abnormal_hypothalamus_physiol0.29453934
98MP0010630_abnormal_cardiac_muscle0.29091473
99MP0009384_cardiac_valve_regurgitation0.28385744
100MP0005319_abnormal_enzyme/_coenzyme0.28090261

Predicted human phenotypes

RankGene SetZ-score
1Decreased circulating renin level (HP:0003351)5.79945539
2Ulnar bowing (HP:0003031)5.37142912
3Atrioventricular block (HP:0001678)4.85850445
4Abnormality of dentin (HP:0010299)4.58445695
5Bifid scrotum (HP:0000048)4.50105775
6Palpitations (HP:0001962)4.35045519
7Prolonged QT interval (HP:0001657)4.30372991
8Bronchomalacia (HP:0002780)4.21283846
9Synostosis involving the elbow (HP:0003938)4.16609832
10Humeroradial synostosis (HP:0003041)4.16609832
11Limb dystonia (HP:0002451)4.12797632
12Syncope (HP:0001279)4.08981875
13Bilateral sensorineural hearing impairment (HP:0008619)3.77393796
14Hyperaldosteronism (HP:0000859)3.41813595
15Abnormality of sodium homeostasis (HP:0010931)3.38716596
16Lip pit (HP:0100267)3.21532162
17Heart block (HP:0012722)3.20458392
18Bowed forearm bones (HP:0003956)3.17903057
19Bowing of the arm (HP:0006488)3.17903057
20Torticollis (HP:0000473)3.15787842
21Dysphonia (HP:0001618)3.14133642
22Abnormal EKG (HP:0003115)3.11059093
23Abnormality of renin-angiotensin system (HP:0000847)3.09616083
24Choanal stenosis (HP:0000452)3.02743681
25Abnormal atrioventricular conduction (HP:0005150)3.01210391
26Vaginal fistula (HP:0004320)2.96198487
27Atonic seizures (HP:0010819)2.88339909
28Poikilocytosis (HP:0004447)2.82546547
29Femoral bowing (HP:0002980)2.82016908
30Primary atrial arrhythmia (HP:0001692)2.81763159
31Labial hypoplasia (HP:0000066)2.80567869
32Craniofacial dystonia (HP:0012179)2.77158180
33Abnormal drinking behavior (HP:0030082)2.68938394
34Polydipsia (HP:0001959)2.68938394
35Abnormality of macular pigmentation (HP:0008002)2.68406524
36Atrial fibrillation (HP:0005110)2.66353669
37Supraventricular tachycardia (HP:0004755)2.66014053
38Supraventricular arrhythmia (HP:0005115)2.60033443
39Protrusio acetabuli (HP:0003179)2.58580262
40Focal dystonia (HP:0004373)2.57375445
41Hypoplastic female external genitalia (HP:0012815)2.40537195
42Turricephaly (HP:0000262)2.34556990
43Anosmia (HP:0000458)2.33300093
44Bony spicule pigmentary retinopathy (HP:0007737)2.30210219
45Hypokalemia (HP:0002900)2.28971446
46Abnormal respiratory epithelium morphology (HP:0012253)2.27305357
47Abnormal respiratory motile cilium morphology (HP:0005938)2.27305357
48Arterial tortuosity (HP:0005116)2.23658425
49Abnormal respiratory motile cilium physiology (HP:0012261)2.16923011
50Hypothermia (HP:0002045)2.16437140
51Wormian bones (HP:0002645)2.15657781
52Cerebral inclusion bodies (HP:0100314)2.15368282
53Arnold-Chiari malformation (HP:0002308)2.15025507
54Polycythemia (HP:0001901)2.12561262
55Abnormal ciliary motility (HP:0012262)2.11090523
56Broad metatarsal (HP:0001783)2.10476648
57Hypercalciuria (HP:0002150)2.07829064
58Vascular tortuosity (HP:0004948)2.01546205
59Renal tubular acidosis (HP:0001947)1.99934945
60Ketoacidosis (HP:0001993)1.99821740
61Adrenal overactivity (HP:0002717)1.98698221
62Scrotal hypoplasia (HP:0000046)1.97702056
63Right ventricular cardiomyopathy (HP:0011663)1.94341020
64Abnormality of potassium homeostasis (HP:0011042)1.91211237
65Annular pancreas (HP:0001734)1.90137662
66Cerebral aneurysm (HP:0004944)1.88821900
67Biliary tract neoplasm (HP:0100574)1.85172483
68Ventricular fibrillation (HP:0001663)1.84631772
69Bradycardia (HP:0001662)1.84122915
70Deep venous thrombosis (HP:0002625)1.83833008
71Chronic bronchitis (HP:0004469)1.83653897
72Insomnia (HP:0100785)1.82307401
73Tarsal synostosis (HP:0008368)1.80178934
74Amyloidosis (HP:0011034)1.78254613
75Abnormality of the dental pulp (HP:0006479)1.77447650
76Neurofibrillary tangles (HP:0002185)1.77444649
77Shallow orbits (HP:0000586)1.75538598
78Enlarged penis (HP:0000040)1.72220491
79Delayed CNS myelination (HP:0002188)1.71323875
80Polyuria (HP:0000103)1.71196369
81Thoracolumbar scoliosis (HP:0002944)1.69108968
82Bronchiectasis (HP:0002110)1.67976773
83Absence seizures (HP:0002121)1.67689829
84Morphological abnormality of the middle ear (HP:0008609)1.66287247
85Abnormal urine output (HP:0012590)1.63132139
86Abnormality of monocarboxylic acid metabolism (HP:0010996)1.61372432
87Generalized tonic-clonic seizures (HP:0002069)1.60420545
88Tinnitus (HP:0000360)1.59127070
89Depression (HP:0000716)1.58492996
90Xerostomia (HP:0000217)1.58463091
91Osteolytic defects of the hand bones (HP:0009699)1.57421463
92Osteolytic defects of the phalanges of the hand (HP:0009771)1.57421463
93Pulmonary embolism (HP:0002204)1.57345993
94Synostosis involving bones of the feet (HP:0009140)1.56902145
95Synostosis involving bones of the lower limbs (HP:0009138)1.56902145
96Supranuclear gaze palsy (HP:0000605)1.56715830
97Premature rupture of membranes (HP:0001788)1.55161813
98Abnormality of renal excretion (HP:0011036)1.52805570
99Spastic diplegia (HP:0001264)1.52661728
100Abnormality of the labia (HP:0000058)1.52375630

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK153.98095430
2TYRO33.38792587
3PAK33.04901777
4RIPK12.82865139
5SIK12.51149565
6CAMK2D2.46489491
7SIK22.46046884
8TRIB32.38978548
9CAMK2B2.37735487
10STK392.20521049
11ERBB32.06149890
12LATS12.05573007
13HIPK22.02396717
14DAPK22.00986903
15LMTK21.90473088
16CSNK1A1L1.86543846
17CAMK2G1.73709364
18MAP3K21.70795877
19FRK1.69655175
20EEF2K1.59729225
21MAPKAPK31.56086499
22TGFBR21.53303575
23NEK11.50863789
24DDR21.50387090
25PKN21.48429968
26FER1.42480183
27NTRK11.37952519
28CSNK1G21.37593014
29CSNK1G31.34494080
30CSNK1G11.27578615
31GRK61.26393645
32MAP3K71.25718207
33TESK11.25388425
34PAK61.22792418
35ALK1.20872299
36MAP2K41.07580542
37SCYL21.07144919
38ERN11.06330116
39MAP3K41.05967444
40KSR21.03691165
41MAP2K11.03129325
42MST1R1.02224159
43PRKCG1.01952077
44EPHB11.01816153
45MINK10.95292936
46FGFR20.94607189
47OXSR10.93108123
48TTK0.88528912
49PRKD10.86276857
50CDK60.85956796
51LRRK20.83286971
52PRKG20.82861748
53TTN0.81421514
54PDGFRA0.79417306
55PTK60.79122614
56PRKCH0.75612306
57PRKD30.75009899
58STK240.74193756
59CAMKK10.73020731
60WNK40.72744521
61PDK30.71361979
62PDK40.71361979
63CAMK2A0.70977868
64ROCK20.69743886
65RPS6KB20.67381471
66CDK50.67090079
67PDPK10.66268619
68DYRK1B0.64693705
69MARK10.60585772
70RET0.58803478
71FYN0.58091660
72TRPM70.57971023
73MAP3K100.57309751
74DAPK10.56213995
75ITK0.53691611
76PHKG20.52191765
77PHKG10.52191765
78INSRR0.49981680
79CSK0.49895301
80BMX0.49418706
81LIMK10.49363902
82PAK20.48259377
83ERBB20.47723310
84ICK0.46616711
85WNK10.46343940
86NTRK30.44989795
87PTK20.43564645
88PDK20.41170778
89MAPK100.39380097
90BCKDK0.39246771
91UHMK10.39069906
92CSNK1E0.38918002
93MAP3K90.38181928
94MET0.37751199
95MAP2K20.37652248
96CDC42BPA0.37032529
97ILK0.36466602
98PRKACG0.36454831
99MST40.36364237
100EPHA30.35616021

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047406.78851652
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.14864242
3Glutathione metabolism_Homo sapiens_hsa004803.12592223
4Caffeine metabolism_Homo sapiens_hsa002323.11507712
5Pentose and glucuronate interconversions_Homo sapiens_hsa000402.96291920
6Thyroid hormone synthesis_Homo sapiens_hsa049182.88536621
7Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.60775663
8Butanoate metabolism_Homo sapiens_hsa006502.38389036
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.33760057
10Cyanoamino acid metabolism_Homo sapiens_hsa004602.22433028
11Arachidonic acid metabolism_Homo sapiens_hsa005901.93357601
12Sulfur metabolism_Homo sapiens_hsa009201.84437323
13Salivary secretion_Homo sapiens_hsa049701.73356065
14Vibrio cholerae infection_Homo sapiens_hsa051101.71910733
15Bile secretion_Homo sapiens_hsa049761.68494365
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.68096775
17Histidine metabolism_Homo sapiens_hsa003401.66617852
18Steroid hormone biosynthesis_Homo sapiens_hsa001401.64781954
19beta-Alanine metabolism_Homo sapiens_hsa004101.57352710
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.44789730
21Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.38055367
22Gastric acid secretion_Homo sapiens_hsa049711.37986909
23Morphine addiction_Homo sapiens_hsa050321.29018703
24Chemical carcinogenesis_Homo sapiens_hsa052041.25659600
25Nitrogen metabolism_Homo sapiens_hsa009101.22165214
26Circadian entrainment_Homo sapiens_hsa047131.15609051
27Insulin secretion_Homo sapiens_hsa049111.14583330
28Collecting duct acid secretion_Homo sapiens_hsa049661.12435978
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.06105793
30Dopaminergic synapse_Homo sapiens_hsa047281.04569049
31GABAergic synapse_Homo sapiens_hsa047270.99815630
32Estrogen signaling pathway_Homo sapiens_hsa049150.97814929
33Aldosterone synthesis and secretion_Homo sapiens_hsa049250.97071428
34Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.95985523
35Synaptic vesicle cycle_Homo sapiens_hsa047210.95816700
36Starch and sucrose metabolism_Homo sapiens_hsa005000.88813175
37Retinol metabolism_Homo sapiens_hsa008300.86424648
38Pyruvate metabolism_Homo sapiens_hsa006200.86025795
39ABC transporters_Homo sapiens_hsa020100.84542881
40Fatty acid degradation_Homo sapiens_hsa000710.83938857
41cAMP signaling pathway_Homo sapiens_hsa040240.83249144
42Ovarian steroidogenesis_Homo sapiens_hsa049130.82286854
43Propanoate metabolism_Homo sapiens_hsa006400.80392542
44Tryptophan metabolism_Homo sapiens_hsa003800.80331945
45Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.77961892
46Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.76308619
47Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73955370
48Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70331365
49Cholinergic synapse_Homo sapiens_hsa047250.67673984
50Glutamatergic synapse_Homo sapiens_hsa047240.67514296
51cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66565592
52Taste transduction_Homo sapiens_hsa047420.65971396
53GnRH signaling pathway_Homo sapiens_hsa049120.65778342
54Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.64261283
55Renin secretion_Homo sapiens_hsa049240.59229934
56Primary bile acid biosynthesis_Homo sapiens_hsa001200.58399143
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.58213369
58Axon guidance_Homo sapiens_hsa043600.57284433
59Melanogenesis_Homo sapiens_hsa049160.54937255
60Dilated cardiomyopathy_Homo sapiens_hsa054140.54433851
61Arginine biosynthesis_Homo sapiens_hsa002200.53959569
62Pancreatic secretion_Homo sapiens_hsa049720.51486384
63Amphetamine addiction_Homo sapiens_hsa050310.49346447
64Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.48942955
652-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.48819037
66Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.48315948
67Oxytocin signaling pathway_Homo sapiens_hsa049210.48081661
68Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.47226905
69Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46812957
70Gap junction_Homo sapiens_hsa045400.45813139
71Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44815041
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44477120
73Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43907299
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.39716100
75Calcium signaling pathway_Homo sapiens_hsa040200.39318922
76Fatty acid biosynthesis_Homo sapiens_hsa000610.37865229
77Sulfur relay system_Homo sapiens_hsa041220.37252612
78Phenylalanine metabolism_Homo sapiens_hsa003600.36221504
79Adherens junction_Homo sapiens_hsa045200.32761720
80Arginine and proline metabolism_Homo sapiens_hsa003300.32010220
81Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.31207279
82Rap1 signaling pathway_Homo sapiens_hsa040150.30985491
83PPAR signaling pathway_Homo sapiens_hsa033200.29683556
84Amoebiasis_Homo sapiens_hsa051460.29619937
85Insulin resistance_Homo sapiens_hsa049310.29255787
86Cocaine addiction_Homo sapiens_hsa050300.29128197
87Long-term potentiation_Homo sapiens_hsa047200.27767623
88Cysteine and methionine metabolism_Homo sapiens_hsa002700.26860756
89Selenocompound metabolism_Homo sapiens_hsa004500.25939667
90Dorso-ventral axis formation_Homo sapiens_hsa043200.25863309
91Type II diabetes mellitus_Homo sapiens_hsa049300.25450111
92Phototransduction_Homo sapiens_hsa047440.25347203
93Platelet activation_Homo sapiens_hsa046110.25338036
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.23502841
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.22945912
96Mineral absorption_Homo sapiens_hsa049780.22182803
97Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.21286152
98Fatty acid metabolism_Homo sapiens_hsa012120.18791924
99N-Glycan biosynthesis_Homo sapiens_hsa005100.17180844
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.16691533

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