BOP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)9.16912045
2homocysteine metabolic process (GO:0050667)7.20391377
3transcription from mitochondrial promoter (GO:0006390)7.17844895
4proline metabolic process (GO:0006560)6.72477500
5replication fork processing (GO:0031297)6.62145754
6DNA deamination (GO:0045006)6.47446845
7embryonic process involved in female pregnancy (GO:0060136)6.46607835
8regulation of plasminogen activation (GO:0010755)6.06229338
9desmosome organization (GO:0002934)5.94632773
10maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)5.74704213
11sulfur amino acid catabolic process (GO:0000098)5.65124140
12positive regulation of protein homooligomerization (GO:0032464)5.38625507
13establishment of apical/basal cell polarity (GO:0035089)5.34756145
14somatic hypermutation of immunoglobulin genes (GO:0016446)5.22006917
15somatic diversification of immune receptors via somatic mutation (GO:0002566)5.22006917
16L-serine metabolic process (GO:0006563)5.20712426
17purine nucleotide salvage (GO:0032261)5.19192972
18regulation of integrin activation (GO:0033623)5.12681044
19pteridine-containing compound biosynthetic process (GO:0042559)5.07113755
20formation of translation preinitiation complex (GO:0001731)5.07042242
21IMP biosynthetic process (GO:0006188)5.02184868
22oxidative demethylation (GO:0070989)5.01194087
23mitochondrial DNA metabolic process (GO:0032042)5.00033315
24mitotic G1 DNA damage checkpoint (GO:0031571)4.95049303
25regulation of translational fidelity (GO:0006450)4.91581610
26cysteine metabolic process (GO:0006534)4.86811462
27tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.83356349
28RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.83356349
29DNA strand renaturation (GO:0000733)4.77843250
30white fat cell differentiation (GO:0050872)4.72227804
31viral mRNA export from host cell nucleus (GO:0046784)4.70371535
32regulation of protein homooligomerization (GO:0032462)4.69518413
33alternative mRNA splicing, via spliceosome (GO:0000380)4.63916607
34establishment or maintenance of monopolar cell polarity (GO:0061339)4.61301292
35establishment of monopolar cell polarity (GO:0061162)4.61301292
36telomere maintenance via semi-conservative replication (GO:0032201)4.60469000
37negative regulation of cell size (GO:0045792)4.50851521
38cellular protein complex localization (GO:0034629)4.45910161
39negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.38535881
40mitotic G1/S transition checkpoint (GO:0044819)4.37642619
41IMP metabolic process (GO:0046040)4.37577391
42folic acid metabolic process (GO:0046655)4.36539016
43microtubule nucleation (GO:0007020)4.33599888
44spliceosomal tri-snRNP complex assembly (GO:0000244)4.29560389
45folic acid-containing compound metabolic process (GO:0006760)4.29558797
46G1 DNA damage checkpoint (GO:0044783)4.27888713
47base-excision repair (GO:0006284)4.27329011
48mRNA cleavage (GO:0006379)4.22178814
49serine family amino acid biosynthetic process (GO:0009070)4.16945831
50DNA strand elongation involved in DNA replication (GO:0006271)4.15837720
51negative regulation of DNA biosynthetic process (GO:2000279)4.14987632
52tetrahydrofolate metabolic process (GO:0046653)4.13318133
53mitotic chromosome condensation (GO:0007076)4.12954751
54poly(A)+ mRNA export from nucleus (GO:0016973)4.11720689
55protein complex localization (GO:0031503)4.07701867
56establishment of protein localization to mitochondrial membrane (GO:0090151)4.05352307
57nucleotide-excision repair, DNA gap filling (GO:0006297)3.98846540
58negative regulation of JAK-STAT cascade (GO:0046426)3.95761798
59negative regulation of cell cycle arrest (GO:0071157)3.90620190
60DNA strand elongation (GO:0022616)3.90182540
61regulation of vitamin D biosynthetic process (GO:0060556)3.89081507
62dosage compensation (GO:0007549)3.88198290
63epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.84010682
64negative regulation of mRNA processing (GO:0050686)3.83125451
65chromosome condensation (GO:0030261)3.82317317
66nucleotide salvage (GO:0043173)3.81728908
67mitochondrial RNA metabolic process (GO:0000959)3.80206481
68negative regulation of telomerase activity (GO:0051974)3.77547967
69embryonic placenta development (GO:0001892)3.72982616
70telomere maintenance via recombination (GO:0000722)3.71749839
71termination of RNA polymerase II transcription (GO:0006369)3.69315550
72negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.68250946
73negative regulation of catenin import into nucleus (GO:0035414)3.68034752
74peptidyl-arginine N-methylation (GO:0035246)3.66550578
75peptidyl-arginine methylation (GO:0018216)3.66550578
76galactose catabolic process (GO:0019388)3.66131952
77regulation of mammary gland epithelial cell proliferation (GO:0033599)3.63060184
78cell migration involved in heart development (GO:0060973)3.62792720
79non-recombinational repair (GO:0000726)3.60586900
80double-strand break repair via nonhomologous end joining (GO:0006303)3.60586900
81negative regulation of RNA splicing (GO:0033119)3.57617665
82maturation of 5.8S rRNA (GO:0000460)3.56126847
83meiotic chromosome segregation (GO:0045132)3.50992333
84glutamine family amino acid biosynthetic process (GO:0009084)3.49627881
85positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.49397086
86positive regulation of mitotic sister chromatid separation (GO:1901970)3.49397086
87positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.49397086
88histone H4-K12 acetylation (GO:0043983)3.48195626
89tRNA modification (GO:0006400)3.47195483
90DNA topological change (GO:0006265)3.46107915
91regulation of posttranscriptional gene silencing (GO:0060147)3.45163101
92regulation of gene silencing by miRNA (GO:0060964)3.45163101
93regulation of gene silencing by RNA (GO:0060966)3.45163101
94positive regulation of protein oligomerization (GO:0032461)3.42761413
95DNA replication initiation (GO:0006270)3.41090969
96regulation of RNA export from nucleus (GO:0046831)3.40907246
97DNA double-strand break processing (GO:0000729)3.39971891
98pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.39861122
99regulation of sister chromatid cohesion (GO:0007063)3.39583242
100apoptotic process involved in morphogenesis (GO:0060561)3.38697555
101pteridine-containing compound metabolic process (GO:0042558)3.38483852
102base-excision repair, AP site formation (GO:0006285)3.38432084
103regulation of double-strand break repair via homologous recombination (GO:0010569)3.38296047
104DNA integration (GO:0015074)3.37584105
105response to vitamin A (GO:0033189)3.32629902
106trophectodermal cell differentiation (GO:0001829)3.30297382
107regulation of tight junction assembly (GO:2000810)3.27432247
108negative regulation of protein oligomerization (GO:0032460)3.25324430
109polyamine biosynthetic process (GO:0006596)3.25320418
110guanosine-containing compound biosynthetic process (GO:1901070)3.24938812
111positive regulation of chromosome segregation (GO:0051984)3.24102205
112positive regulation by host of viral transcription (GO:0043923)3.23267730
113rRNA transcription (GO:0009303)3.22967516
114mitotic sister chromatid segregation (GO:0000070)3.22759435
115mitotic recombination (GO:0006312)3.22558563
116telomere maintenance via telomere lengthening (GO:0010833)3.22553393
117regulation of DNA damage checkpoint (GO:2000001)3.20508575
118negative regulation of mRNA metabolic process (GO:1903312)3.18216025
119histone arginine methylation (GO:0034969)3.18114851
120regulation of protein oligomerization (GO:0032459)3.15883815
121protein retention in ER lumen (GO:0006621)3.15833432
122positive regulation of developmental pigmentation (GO:0048087)3.15576916
123cellular response to zinc ion (GO:0071294)3.14634092
124embryonic camera-type eye development (GO:0031076)3.13255159
125regulation of double-strand break repair (GO:2000779)3.12639513
126negative regulation of fatty acid biosynthetic process (GO:0045717)3.11731759
127nuclear envelope reassembly (GO:0031468)3.10880786
128mitotic nuclear envelope reassembly (GO:0007084)3.10880786
129regulation of vitamin metabolic process (GO:0030656)3.10512829
130negative regulation of Ras GTPase activity (GO:0034261)3.10228864
131kinetochore assembly (GO:0051382)3.05687479
132alpha-amino acid biosynthetic process (GO:1901607)3.05079929
133DNA packaging (GO:0006323)3.04946594
134peptidyl-arginine omega-N-methylation (GO:0035247)3.04779401
135cellular response to ATP (GO:0071318)3.03420534
136nodal signaling pathway (GO:0038092)3.02842271
137peptidyl-proline hydroxylation (GO:0019511)3.02559331
138activation of Rac GTPase activity (GO:0032863)3.01489676
139mitotic nuclear envelope disassembly (GO:0007077)2.99843040
140DNA demethylation (GO:0080111)2.98906759
141mRNA export from nucleus (GO:0006406)2.97582025
142maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.96437091
1434-hydroxyproline metabolic process (GO:0019471)2.96086959
144determination of adult lifespan (GO:0008340)2.94573635
145DNA ligation (GO:0006266)2.94204795
146GDP-mannose metabolic process (GO:0019673)2.93818038
147rRNA methylation (GO:0031167)2.93728196
148cellular response to epidermal growth factor stimulus (GO:0071364)2.93495245
149folic acid-containing compound biosynthetic process (GO:0009396)2.91169286
150mitochondrial DNA replication (GO:0006264)2.89055044
151pseudouridine synthesis (GO:0001522)2.88926980
152rRNA modification (GO:0000154)2.85849375
153phosphatidylglycerol biosynthetic process (GO:0006655)2.83718779
154RNA export from nucleus (GO:0006405)2.83469679
155DNA unwinding involved in DNA replication (GO:0006268)2.83415172
156* ribosome biogenesis (GO:0042254)2.77193445
157COPII vesicle coating (GO:0048208)2.76681561
158sulfur amino acid biosynthetic process (GO:0000097)2.75670008
159COPI coating of Golgi vesicle (GO:0048205)2.74919183
160Golgi transport vesicle coating (GO:0048200)2.74919183
161galactose metabolic process (GO:0006012)2.74468432
162regulation of translational termination (GO:0006449)2.74164313
163tRNA methylation (GO:0030488)2.73841272
164UTP biosynthetic process (GO:0006228)2.72990759
165regulation of gonadotropin secretion (GO:0032276)2.70098893
166GMP metabolic process (GO:0046037)2.69236597
167negative regulation of keratinocyte proliferation (GO:0010839)2.68018066
168adenosine metabolic process (GO:0046085)2.67762495
169cellular modified amino acid catabolic process (GO:0042219)2.65785361
170regulation of superoxide anion generation (GO:0032928)2.65345637
171ribosomal small subunit biogenesis (GO:0042274)2.65338741
172folic acid transport (GO:0015884)2.63926293
173regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.62723520
174negative regulation of alcohol biosynthetic process (GO:1902931)2.62466956
175regulation of DNA biosynthetic process (GO:2000278)2.61744367
176activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.61116786
177tricarboxylic acid metabolic process (GO:0072350)2.60883022
178nucleoside transmembrane transport (GO:1901642)2.60657269
179negative regulation of chondrocyte differentiation (GO:0032331)2.60475020
180positive regulation of nuclease activity (GO:0032075)2.60341575
181negative regulation of viral release from host cell (GO:1902187)2.60200394
182nucleobase biosynthetic process (GO:0046112)2.57069805

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.75557496
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.61556734
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.51044903
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.36990553
5* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.21645986
6SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.86284849
7* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.72487837
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.64745951
9ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.62009589
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.48603257
11THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.48293275
12VDR_21846776_ChIP-Seq_THP-1_Human2.40120191
13KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.35942725
14KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.35942725
15KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.35942725
16* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.27419873
17TP63_17297297_ChIP-ChIP_HaCaT_Human2.21512585
18MYC_22102868_ChIP-Seq_BL_Human2.16957403
19PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.15519476
20* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.06752896
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.04866930
22KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.97460853
23JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.94238744
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.91725199
25STAT3_1855785_ChIP-Seq_MESCs_Mouse1.90722473
26E2F4_17652178_ChIP-ChIP_JURKAT_Human1.90072625
27POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.86875802
28RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.85898874
29ETS1_20019798_ChIP-Seq_JURKAT_Human1.82372656
30NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.80852487
31NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.79790334
32SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.78765331
33SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.76752276
34NANOG_18555785_ChIP-Seq_MESCs_Mouse1.73779509
35THAP11_20581084_ChIP-Seq_MESCs_Mouse1.69037367
36POU5F1_16518401_ChIP-PET_MESCs_Mouse1.66173433
37E2F1_18555785_ChIP-Seq_MESCs_Mouse1.65356587
38* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.61985033
39XRN2_22483619_ChIP-Seq_HELA_Human1.61540399
40MYCN_18555785_ChIP-Seq_MESCs_Mouse1.61531034
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.58087107
42P68_20966046_ChIP-Seq_HELA_Human1.57937893
43KLF4_18555785_ChIP-Seq_MESCs_Mouse1.56130697
44NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.55199084
45* LXR_22292898_ChIP-Seq_THP-1_Human1.54131775
46CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.53694387
47TCF3_18692474_ChIP-Seq_MESCs_Mouse1.52903492
48HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.52166173
49CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.51773207
50NANOG_21062744_ChIP-ChIP_HESCs_Human1.50981407
51TCF3_18692474_ChIP-Seq_MEFs_Mouse1.50826073
52YY1_21170310_ChIP-Seq_MESCs_Mouse1.50825339
53RARG_19884340_ChIP-ChIP_MEFs_Mouse1.49272407
54* GABP_19822575_ChIP-Seq_HepG2_Human1.48556339
55TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46658071
56CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.46576070
57DCP1A_22483619_ChIP-Seq_HELA_Human1.44315743
58AR_21909140_ChIP-Seq_LNCAP_Human1.43775665
59ZNF263_19887448_ChIP-Seq_K562_Human1.43642276
60ESR1_15608294_ChIP-ChIP_MCF-7_Human1.42888243
61KDM5A_27292631_Chip-Seq_BREAST_Human1.39033866
62* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.38750962
63SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.37810384
64SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.37252542
65E2F1_21310950_ChIP-Seq_MCF-7_Human1.36290226
66MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.36261266
67ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.34766032
68SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.33788831
69EST1_17652178_ChIP-ChIP_JURKAT_Human1.33384819
70ZFX_18555785_ChIP-Seq_MESCs_Mouse1.31583069
71POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.31085734
72TTF2_22483619_ChIP-Seq_HELA_Human1.29747095
73TCF7_22412390_ChIP-Seq_EML_Mouse1.29509418
74ATF3_27146783_Chip-Seq_COLON_Human1.27282459
75DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.26997049
76* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.26908974
77NCOR1_26117541_ChIP-Seq_K562_Human1.25978307
78UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.25292460
79* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.24711286
80BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.23970172
81* TET1_21451524_ChIP-Seq_MESCs_Mouse1.22640521
82POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.21580041
83TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.21340775
84RACK7_27058665_Chip-Seq_MCF-7_Human1.21278303
85NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.20824516
86ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.20671537
87CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.20653423
88EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18805361
89TP53_22127205_ChIP-Seq_IMR90_Human1.18523491
90GABP_17652178_ChIP-ChIP_JURKAT_Human1.18169940
91NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.16967903
92KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.16233352
93ZFP281_18757296_ChIP-ChIP_E14_Mouse1.15860016
94NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.15402959
95ELK3_25401928_ChIP-Seq_HUVEC_Human1.15384811
96* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.15329576
97SOX2_18555785_ChIP-Seq_MESCs_Mouse1.14604926
98KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.14323356
99* TBX5_21415370_ChIP-Seq_HL-1_Mouse1.14239180
100OCT4_18692474_ChIP-Seq_MEFs_Mouse1.13869772
101VDR_23849224_ChIP-Seq_CD4+_Human1.13276084
102KDM2B_26808549_Chip-Seq_DND41_Human1.12089207
103SOX2_18692474_ChIP-Seq_MEFs_Mouse1.11483768
104CTCF_27219007_Chip-Seq_ERYTHROID_Human1.10942247
105SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.10461661
106KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.09738475
107SOX2_18692474_ChIP-Seq_MESCs_Mouse1.09087109
108PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07911966
109ERG_21242973_ChIP-ChIP_JURKAT_Human1.07874660
110MAF_26560356_Chip-Seq_TH2_Human1.07707068
111EGR1_19374776_ChIP-ChIP_THP-1_Human1.07093625
112NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.06869969
113ZFP281_27345836_Chip-Seq_ESCs_Mouse1.06492549
114SA1_27219007_Chip-Seq_ERYTHROID_Human1.06307823
115TFEB_21752829_ChIP-Seq_HELA_Human1.06220536
116SRY_22984422_ChIP-ChIP_TESTIS_Rat1.04800593
117* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.04060524
118SMC4_20622854_ChIP-Seq_HELA_Human1.03134351
119SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.02886581
120ETS1_21867929_ChIP-Seq_TH2_Mouse1.02561909
121CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.02182739
122CREB1_15753290_ChIP-ChIP_HEK293T_Human1.02100284
123NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.02032195
124KDM2B_26808549_Chip-Seq_SUP-B15_Human1.01970661
125SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01801656
126P300_27058665_Chip-Seq_ZR-75-30cells_Human1.01650376
127CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.01454420
128CREB1_26743006_Chip-Seq_LNCaP_Human1.00423576
129BCOR_27268052_Chip-Seq_Bcells_Human0.99895838
130ELF1_17652178_ChIP-ChIP_JURKAT_Human0.99629098
131KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.98316340
132PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.97339070
133* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.96857221
134HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.96747019
135SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.96480706
136KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.95775726
137FOXP1_21924763_ChIP-Seq_HESCs_Human0.95410441
138RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.95390395
139KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.95170055
140KDM2B_26808549_Chip-Seq_K562_Human0.95095113
141NANOG_18692474_ChIP-Seq_MESCs_Mouse0.94936119
142TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94405551

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication6.20633092
2MP0009278_abnormal_bone_marrow3.92998975
3MP0005670_abnormal_white_adipose3.78159179
4MP0010030_abnormal_orbit_morphology3.36196820
5MP0010094_abnormal_chromosome_stability3.33176320
6MP0005360_urolithiasis3.27584205
7MP0005171_absent_coat_pigmentation3.27168754
8MP0004957_abnormal_blastocyst_morpholog3.03491202
9MP0000013_abnormal_adipose_tissue2.95990380
10MP0001661_extended_life_span2.95798188
11MP0004233_abnormal_muscle_weight2.91313163
12MP0003111_abnormal_nucleus_morphology2.76152572
13MP0010352_gastrointestinal_tract_polyps2.52250343
14MP0000003_abnormal_adipose_tissue2.49585149
15MP0003693_abnormal_embryo_hatching2.45961652
16MP0003183_abnormal_peptide_metabolism2.33439615
17MP0002009_preneoplasia2.28120696
18MP0003077_abnormal_cell_cycle2.24455219
19MP0001545_abnormal_hematopoietic_system2.23356187
20MP0005397_hematopoietic_system_phenotyp2.23356187
21MP0003890_abnormal_embryonic-extraembry2.20133915
22MP0005451_abnormal_body_composition2.18325524
23MP0008058_abnormal_DNA_repair2.17938701
24MP0001849_ear_inflammation2.14620777
25MP0003786_premature_aging2.12601881
26MP0000678_abnormal_parathyroid_gland2.11357595
27MP0002877_abnormal_melanocyte_morpholog2.10832969
28MP0008932_abnormal_embryonic_tissue2.00361052
29MP0010234_abnormal_vibrissa_follicle1.97717020
30MP0008995_early_reproductive_senescence1.92885919
31MP0005076_abnormal_cell_differentiation1.92335138
32MP0003119_abnormal_digestive_system1.89558177
33MP0004133_heterotaxia1.88817989
34MP0001697_abnormal_embryo_size1.84384908
35MP0000490_abnormal_crypts_of1.82927695
36MP0002086_abnormal_extraembryonic_tissu1.82204796
37MP0008877_abnormal_DNA_methylation1.81769174
38MP0002653_abnormal_ependyma_morphology1.78823349
39MP0003283_abnormal_digestive_organ1.78603854
40MP0002084_abnormal_developmental_patter1.77843527
41MP0001730_embryonic_growth_arrest1.77256990
42MP0004197_abnormal_fetal_growth/weight/1.74507884
43MP0000350_abnormal_cell_proliferation1.69867310
44MP0002085_abnormal_embryonic_tissue1.68682605
45MP0005174_abnormal_tail_pigmentation1.67375336
46MP0005380_embryogenesis_phenotype1.61574000
47MP0001672_abnormal_embryogenesis/_devel1.61574000
48MP0005666_abnormal_adipose_tissue1.54237562
49MP0001293_anophthalmia1.53738806
50MP0003453_abnormal_keratinocyte_physiol1.53161321
51MP0002249_abnormal_larynx_morphology1.44630994
52MP0000747_muscle_weakness1.42052626
53MP0003567_abnormal_fetal_cardiomyocyte1.40524920
54MP0010307_abnormal_tumor_latency1.40062057
55MP0005646_abnormal_pituitary_gland1.39969652
56MP0002282_abnormal_trachea_morphology1.39252608
57MP0002080_prenatal_lethality1.38613900
58MP0005375_adipose_tissue_phenotype1.38323265
59MP0003984_embryonic_growth_retardation1.34812740
60MP0000566_synostosis1.33746588
61MP0002019_abnormal_tumor_incidence1.33243918
62MP0000537_abnormal_urethra_morphology1.31275860
63MP0006072_abnormal_retinal_apoptosis1.30246056
64MP0002088_abnormal_embryonic_growth/wei1.29479548
65MP0005075_abnormal_melanosome_morpholog1.29467023
66MP0000371_diluted_coat_color1.27240626
67MP0002269_muscular_atrophy1.24478132
68MP0000733_abnormal_muscle_development1.24031086
69MP0000534_abnormal_ureter_morphology1.21265128
70MP0002111_abnormal_tail_morphology1.20559419
71MP0003172_abnormal_lysosome_physiology1.16565289
72MP0003705_abnormal_hypodermis_morpholog1.13372889
73MP0009672_abnormal_birth_weight1.12371622
74MP0002396_abnormal_hematopoietic_system1.11390402
75MP0009333_abnormal_splenocyte_physiolog1.11177644
76MP0000313_abnormal_cell_death1.10177315
77MP0004858_abnormal_nervous_system1.08547482
78MP0000015_abnormal_ear_pigmentation1.08360060
79MP0000751_myopathy1.08338974
80MP0000470_abnormal_stomach_morphology1.07962374
81MP0001216_abnormal_epidermal_layer1.06955521
82MP0000750_abnormal_muscle_regeneration1.04082004
83MP0003718_maternal_effect1.03277519
84MP0001348_abnormal_lacrimal_gland1.03272769
85MP0003942_abnormal_urinary_system1.02409758
86MP0000858_altered_metastatic_potential1.02288414
87MP0002089_abnormal_postnatal_growth/wei0.99783709
88MP0002796_impaired_skin_barrier0.98643744
89MP0009053_abnormal_anal_canal0.96834441
90MP0000579_abnormal_nail_morphology0.96628431
91MP0000685_abnormal_immune_system0.95675168
92MP0003315_abnormal_perineum_morphology0.95519940
93MP0008007_abnormal_cellular_replicative0.93280553
94MP0005501_abnormal_skin_physiology0.92859234
95MP0002938_white_spotting0.92850722
96MP0000759_abnormal_skeletal_muscle0.91828710
97MP0004264_abnormal_extraembryonic_tissu0.89417315
98MP0003186_abnormal_redox_activity0.89228227
99MP0005023_abnormal_wound_healing0.89125077
100MP0005623_abnormal_meninges_morphology0.88728616
101MP0005266_abnormal_metabolism0.87606823
102MP0002075_abnormal_coat/hair_pigmentati0.87493645
103MP0002932_abnormal_joint_morphology0.86052437
104MP0003566_abnormal_cell_adhesion0.84763343
105MP0009931_abnormal_skin_appearance0.84758317
106MP0002405_respiratory_system_inflammati0.82978835
107MP0002697_abnormal_eye_size0.82670120
108MP0000516_abnormal_urinary_system0.82378715
109MP0005367_renal/urinary_system_phenotyp0.82378715
110MP0001340_abnormal_eyelid_morphology0.82213247
111MP0008260_abnormal_autophagy0.81124759
112MP0002114_abnormal_axial_skeleton0.79938973
113MP0000689_abnormal_spleen_morphology0.79935428
114MP0000462_abnormal_digestive_system0.79036563
115MP0003763_abnormal_thymus_physiology0.78513681
116MP0004808_abnormal_hematopoietic_stem0.76999033
117MP0000477_abnormal_intestine_morphology0.76534232
118MP0003935_abnormal_craniofacial_develop0.76242642
119MP0001145_abnormal_male_reproductive0.76079550
120MP0000703_abnormal_thymus_morphology0.73254189
121MP0003755_abnormal_palate_morphology0.72079864
122MP0010771_integument_phenotype0.69793507
123MP0005058_abnormal_lysosome_morphology0.69515240
124MP0002060_abnormal_skin_morphology0.69501811
125MP0003115_abnormal_respiratory_system0.68644676
126MP0000432_abnormal_head_morphology0.68505239
127MP0004185_abnormal_adipocyte_glucose0.68428731
128MP0000639_abnormal_adrenal_gland0.67940596
129MP0001270_distended_abdomen0.67863950
130MP0004947_skin_inflammation0.67344260
131MP0005257_abnormal_intraocular_pressure0.66995934
132MP0005621_abnormal_cell_physiology0.66970427
133MP0000762_abnormal_tongue_morphology0.66969741
134MP0009115_abnormal_fat_cell0.66864726
135MP0001186_pigmentation_phenotype0.66827141
136MP0002098_abnormal_vibrissa_morphology0.66024330
137MP0000681_abnormal_thyroid_gland0.65732817
138MP0003806_abnormal_nucleotide_metabolis0.65648282
139MP0000627_abnormal_mammary_gland0.65593812
140MP0001243_abnormal_dermal_layer0.65590187
141MP0002970_abnormal_white_adipose0.64385208
142MP0002736_abnormal_nociception_after0.64174595
143MP0002132_abnormal_respiratory_system0.63747511
144MP0001915_intracranial_hemorrhage0.63120506
145MP0002722_abnormal_immune_system0.62983219
146MP0008770_decreased_survivor_rate0.61725886
147MP0010630_abnormal_cardiac_muscle0.61197067
148MP0000467_abnormal_esophagus_morphology0.61172303
149MP0002116_abnormal_craniofacial_bone0.60942379
150MP0002398_abnormal_bone_marrow0.59349628
151MP0002166_altered_tumor_susceptibility0.58669207

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of pyruvate family amino acid metabolism (HP:0010915)5.55397221
2Abnormality of alanine metabolism (HP:0010916)5.55397221
3Hyperalaninemia (HP:0003348)5.55397221
4Rib fusion (HP:0000902)5.25136351
5Annular pancreas (HP:0001734)4.76646092
6Pustule (HP:0200039)4.73604473
7Facial hemangioma (HP:0000329)4.73362409
8Abnormal umbilical cord blood vessels (HP:0011403)4.57997035
9Single umbilical artery (HP:0001195)4.57997035
10Abnormality of the fetal cardiovascular system (HP:0010948)4.57997035
11Concave nail (HP:0001598)4.51463885
12Rectal fistula (HP:0100590)4.43209088
13Rectovaginal fistula (HP:0000143)4.43209088
14Poikiloderma (HP:0001029)4.42388268
15Esophageal varix (HP:0002040)4.23760886
16Ulnar bowing (HP:0003031)4.21118418
17Intestinal fistula (HP:0100819)4.05561996
18Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.99455135
19Increased IgM level (HP:0003496)3.98826802
20Vaginal fistula (HP:0004320)3.98607276
21Abnormality of the umbilical cord (HP:0010881)3.91395907
22Alopecia of scalp (HP:0002293)3.90916851
23Tongue fasciculations (HP:0001308)3.72462184
24Turricephaly (HP:0000262)3.70100295
25Short humerus (HP:0005792)3.69182022
26Aplasia/hypoplasia of the humerus (HP:0006507)3.68120359
27Birth length less than 3rd percentile (HP:0003561)3.66860318
28Selective tooth agenesis (HP:0001592)3.63620418
29Myopathic facies (HP:0002058)3.49396624
30Muscle fibrillation (HP:0010546)3.47055057
31Basal cell carcinoma (HP:0002671)3.43821357
32Squamous cell carcinoma (HP:0002860)3.43605908
33Biconcave vertebral bodies (HP:0004586)3.42888372
34Myocardial infarction (HP:0001658)3.39679329
35Absent radius (HP:0003974)3.39457823
36Absent thumb (HP:0009777)3.33833379
37Orthostatic hypotension (HP:0001278)3.33265581
38White forelock (HP:0002211)3.32962802
39Constricted visual fields (HP:0001133)3.27478903
40Abnormal hemoglobin (HP:0011902)3.27094832
41Hypochromic microcytic anemia (HP:0004840)3.25748532
42Vertebral hypoplasia (HP:0008417)3.19265240
43Aplasia/Hypoplasia of the vertebrae (HP:0008515)3.19265240
44Absent forearm bone (HP:0003953)3.17745621
45Aplasia involving forearm bones (HP:0009822)3.17745621
46Congenital hip dislocation (HP:0001374)3.14617046
47Patellar aplasia (HP:0006443)3.11882299
48Coronal craniosynostosis (HP:0004440)3.08998037
49Intestinal atresia (HP:0011100)3.08858544
50Spontaneous hematomas (HP:0007420)3.08380021
51Short chin (HP:0000331)3.06186809
52Male infertility (HP:0003251)3.06042179
53Homocystinuria (HP:0002156)3.03279921
54Abnormality of homocysteine metabolism (HP:0010919)3.03279921
55Progressive muscle weakness (HP:0003323)3.01107548
56Reduced subcutaneous adipose tissue (HP:0003758)2.97634870
57Fatigue (HP:0012378)2.89162834
58Insomnia (HP:0100785)2.88635719
59Aplasia/Hypoplasia of the patella (HP:0006498)2.85857495
60Abnormality of male internal genitalia (HP:0000022)2.83792331
61Premature graying of hair (HP:0002216)2.79743292
62Distal lower limb amyotrophy (HP:0008944)2.79572669
63Patchy hypopigmentation of hair (HP:0011365)2.78254202
64Disproportionate tall stature (HP:0001519)2.75223299
65Broad alveolar ridges (HP:0000187)2.72222220
66Anteriorly placed anus (HP:0001545)2.69579215
67Abnormality of the aortic arch (HP:0012303)2.69056709
68Premature skin wrinkling (HP:0100678)2.67263115
69Hyperacusis (HP:0010780)2.66800671
70Astrocytoma (HP:0009592)2.64724201
71Abnormality of the astrocytes (HP:0100707)2.64724201
72Dysautonomia (HP:0002459)2.60248579
73Albinism (HP:0001022)2.55916149
74Abnormality of the labia minora (HP:0012880)2.54575752
75Heterochromia iridis (HP:0001100)2.52819272
76Progressive external ophthalmoplegia (HP:0000590)2.49088317
77Vertebral fusion (HP:0002948)2.48535170
78Chromosomal breakage induced by crosslinking agents (HP:0003221)2.48257952
79Flat acetabular roof (HP:0003180)2.47811932
80Abnormalities of placenta or umbilical cord (HP:0001194)2.46494256
81Joint stiffness (HP:0001387)2.45388648
82Large for gestational age (HP:0001520)2.44583266
83Bowed forearm bones (HP:0003956)2.40670786
84Bowing of the arm (HP:0006488)2.40670786
85Ependymoma (HP:0002888)2.37678446
86IgA deficiency (HP:0002720)2.37045729
87Alacrima (HP:0000522)2.36343907
88Long palpebral fissure (HP:0000637)2.35925765
89Urinary glycosaminoglycan excretion (HP:0003541)2.35455751
90Mucopolysacchariduria (HP:0008155)2.35455751
91Aplasia/Hypoplasia of the sacrum (HP:0008517)2.32823670
92Cerebral aneurysm (HP:0004944)2.32801046
93Diaphragmatic weakness (HP:0009113)2.31652438
94Hypotrichosis (HP:0001006)2.31576480
95Volvulus (HP:0002580)2.31339102
96Hypochromic anemia (HP:0001931)2.31131217
97Abnormal number of incisors (HP:0011064)2.31104876
98Hypotelorism (HP:0000601)2.30856215
99Acute lymphatic leukemia (HP:0006721)2.30209550
100Bifid uvula (HP:0000193)2.27703224
101Hypopigmentation of the fundus (HP:0007894)2.27693919
102Pancreatic islet-cell hyperplasia (HP:0004510)2.26513960
103Congenital sensorineural hearing impairment (HP:0008527)2.26178272
104Abnormality of the tricuspid valve (HP:0001702)2.25919251
105Choanal stenosis (HP:0000452)2.23985480
106Ileus (HP:0002595)2.23264510
107Abnormality of the phalanges of the hallux (HP:0010057)2.22677057
108Difficulty climbing stairs (HP:0003551)2.21508096
109Neoplasm of the oral cavity (HP:0100649)2.21203430
110Anorexia (HP:0002039)2.18472715
111Thin ribs (HP:0000883)2.18436360
112Conjunctival telangiectasia (HP:0000524)2.17806315
113Capillary hemangiomas (HP:0005306)2.17681145
114Hypoalphalipoproteinemia (HP:0003233)2.16798982
115Polygenic inheritance (HP:0010982)2.16463524
116Visceral angiomatosis (HP:0100761)2.15861427
117Spinal muscular atrophy (HP:0007269)2.15454197
118Muscle fiber atrophy (HP:0100295)2.15279811
119Aplasia of the musculature (HP:0100854)2.14088005
120Hamartoma (HP:0010566)2.13876230
121Decreased subcutaneous fat (HP:0001002)2.11967417
122Trismus (HP:0000211)2.11872339
123Hypertensive crisis (HP:0100735)2.11591668
124Abnormality of sulfur amino acid metabolism (HP:0004339)2.11299141
125Abnormality of subcutaneous fat tissue (HP:0001001)2.10917412
126Back pain (HP:0003418)2.10271352
127Hemangiomatosis (HP:0007461)2.09719549
128Short 5th finger (HP:0009237)2.08497588
129Hypoplasia of the radius (HP:0002984)2.07695170
130Ragged-red muscle fibers (HP:0003200)2.06740932
131Chromsome breakage (HP:0040012)2.05736154
132Polycythemia (HP:0001901)2.04032268
133Cholecystitis (HP:0001082)2.03299103
134Abnormal gallbladder physiology (HP:0012438)2.03299103
135Abnormality of polysaccharide metabolism (HP:0011012)2.02573693
136Abnormality of glycosaminoglycan metabolism (HP:0004371)2.02573693
137Abnormality of mucopolysaccharide metabolism (HP:0011020)2.02573693
138Reticulocytopenia (HP:0001896)1.99080232
139Abnormality of the lower motor neuron (HP:0002366)1.97866684
140Abnormality of the thoracic spine (HP:0100711)1.97691879
141Breast hypoplasia (HP:0003187)1.96994836
142Glioma (HP:0009733)1.96568963
143Dysostosis multiplex (HP:0000943)1.95809712
144Abnormality of cochlea (HP:0000375)1.95475751
145Growth hormone excess (HP:0000845)1.95108058
146Gastrointestinal atresia (HP:0002589)1.94678894
147Elevated alkaline phosphatase (HP:0003155)1.94394074
148Achilles tendon contracture (HP:0001771)1.93919019
149Type 2 muscle fiber atrophy (HP:0003554)1.93569537
150Increased number of teeth (HP:0011069)1.92724350
151Lower limb amyotrophy (HP:0007210)1.92475047
152Increased connective tissue (HP:0009025)1.92214302
153Popliteal pterygium (HP:0009756)1.91913539
154Abnormality of the ileum (HP:0001549)1.91608249
155Gastrointestinal dysmotility (HP:0002579)1.91080519
156Hypokinesia (HP:0002375)1.89676342
157Conjugated hyperbilirubinemia (HP:0002908)1.87608195
158Premature rupture of membranes (HP:0001788)1.86931771
159Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.85383706
160Split hand (HP:0001171)1.84943094
161Hypoplastic left heart (HP:0004383)1.83893308
162Short thumb (HP:0009778)1.83591321
163Poor speech (HP:0002465)1.83546276
164Arteriovenous malformation (HP:0100026)1.83370139
165Hypercortisolism (HP:0001578)1.82841224
166Abnormality of the distal phalanges of the toes (HP:0010182)1.82652919
167Redundant skin (HP:0001582)1.82591978
168Premature ovarian failure (HP:0008209)1.82403068
169Cortical visual impairment (HP:0100704)1.80827657
170Hypergonadotropic hypogonadism (HP:0000815)1.80779268
171Abnormality of alkaline phosphatase activity (HP:0004379)1.80728602
172Rhabdomyosarcoma (HP:0002859)1.80616647
173Generalized amyotrophy (HP:0003700)1.80222707
174Insulin resistance (HP:0000855)1.79788923
175Duplication of thumb phalanx (HP:0009942)1.78384226
176Thoracic kyphosis (HP:0002942)1.78054215
177Abnormality of glycolysis (HP:0004366)1.77924664
178Broad face (HP:0000283)1.77028184
179Hypoparathyroidism (HP:0000829)1.76970044
180Broad distal phalanx of finger (HP:0009836)1.73641724
181Abnormal enzyme/coenzyme activity (HP:0012379)1.72299665
182Abnormality of the Achilles tendon (HP:0005109)1.71631863
183Complete atrioventricular canal defect (HP:0001674)1.68981606
184Abnormality of reticulocytes (HP:0004312)1.66932841
185Decreased electroretinogram (ERG) amplitude (HP:0000654)1.66303400
186Metaphyseal cupping (HP:0003021)1.65146171
187Distal lower limb muscle weakness (HP:0009053)1.62588747
188Abnormality of serum amino acid levels (HP:0003112)1.62099499
189Ureteral duplication (HP:0000073)1.61528898
190Abnormality of carpal bone ossification (HP:0006257)1.61370264
191Slender long bone (HP:0003100)1.61206761
192Bowel incontinence (HP:0002607)1.60077691
193Focal segmental glomerulosclerosis (HP:0000097)1.58846885
194Abnormal ossification of hand bones (HP:0005921)1.57964849
195Distal upper limb amyotrophy (HP:0007149)1.57426123

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK5.53851104
2DDR24.47431159
3MAPK154.25052857
4MAP3K63.98838926
5SMG13.95362835
6MAP2K33.70748160
7MAP3K113.50075110
8IRAK33.18379809
9MAP3K32.92850332
10TYRO32.67561537
11MATK2.63178904
12SIK12.61957831
13FGR2.51622360
14PINK12.46836755
15PIM22.45435752
16DAPK12.36886276
17BMX2.27885311
18MST1R2.22009224
19CDK72.07848734
20UHMK12.02679285
21CDK91.97373840
22CSK1.95386399
23PDGFRA1.90877403
24PRKD21.78698144
25DYRK1B1.69329438
26YES11.68872396
27TTN1.64925823
28LMTK21.58502571
29PIM11.57519743
30JAK31.56186008
31CDC71.51815310
32MAP3K101.49748138
33BUB11.47866615
34VRK21.46286317
35LATS21.42857506
36CDK61.41756550
37ERN11.37105290
38TRIB31.35284448
39WEE11.24390937
40CHEK21.23682330
41PLK11.21458095
42TRPM71.20929613
43RPS6KC11.18273234
44RPS6KL11.18273234
45CDK121.14378610
46PTK61.13245181
47NEK21.10294027
48RPS6KB21.09761167
49PRKD31.07991419
50AKT31.04775312
51RPS6KA61.03891755
52IRAK21.03427293
53DYRK31.01911017
54ARAF1.01101790
55MAPK111.00449751
56EPHA20.98870564
57ATR0.97523118
58CDC42BPA0.93337888
59GSK3A0.91912371
60CCNB10.89507980
61MET0.87708512
62MTOR0.87517734
63TAOK20.84721329
64EPHB20.83475197
65TESK20.82533435
66NEK10.81647798
67BRAF0.78666737
68TESK10.77960966
69CDK80.74554392
70AURKA0.73730097
71RPS6KA10.72219020
72EEF2K0.72031652
73CDK20.70156410
74MAP4K10.68752037
75BRSK10.67717724
76NME20.67293154
77TSSK60.66532485
78CDK40.66290348
79TTK0.65753913
80AURKB0.65062499
81CHEK10.63863256
82ALK0.63696229
83PBK0.63309801
84KDR0.62499632
85RAF10.62234657
86IRAK40.59099231
87PHKG10.58530235
88PHKG20.58530235
89STK100.55310924
90MAP2K10.55227506
91FGFR40.55174597
92MAP3K80.54528429
93CSNK2A10.51955860
94PAK40.50338191
95HIPK20.49642666
96SCYL20.49282809
97ILK0.48516035
98RPS6KB10.47821008
99MAP3K10.47452742
100CSNK2A20.47158493
101ATM0.46605610
102SRPK10.46284748
103PRKG20.44700139
104TLK10.44604722
105SGK30.44531687
106TAOK10.44519185
107PAK20.44485606
108NME10.42702015
109PRKAA10.42661670
110EGFR0.41632185
111CAMK2G0.41483304
112NTRK20.41177292
113PAK10.40870527
114MAPKAPK30.39462335
115LYN0.39164882
116MAP2K20.38799522
117CDK10.38195362
118RIPK10.38030188
119TAF10.37960539
120MAPK10.36045753
121SGK4940.35207074
122SGK2230.35207074
123CAMK2B0.34934236
124PDPK10.34320069
125FLT30.34277810
126EIF2AK10.33936888
127MAPK30.33647869
128PKN20.33639781
129NTRK10.33504617
130LRRK20.33386790
131PRPF4B0.32962858
132STK30.32729834
133MAPK140.32298421
134MAPK40.31810416
135PRKCI0.30267153
136MAPKAPK20.28048698
137PDGFRB0.27942089
138DYRK20.25404846
139FGFR10.24574088
140CDK11A0.24476707
141TNK20.23522753
142PTK20.23346950
143AKT20.22860663
144MAPK100.22524078
145CDK150.21781957
146INSR0.21385875

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034305.20846061
2DNA replication_Homo sapiens_hsa030304.76559459
3Base excision repair_Homo sapiens_hsa034104.62134591
4Fatty acid biosynthesis_Homo sapiens_hsa000613.72195786
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.21984229
6Spliceosome_Homo sapiens_hsa030402.88295881
7RNA transport_Homo sapiens_hsa030132.71412524
8Nucleotide excision repair_Homo sapiens_hsa034202.69624006
9Homologous recombination_Homo sapiens_hsa034402.23622642
10mRNA surveillance pathway_Homo sapiens_hsa030152.07970106
11Ribosome_Homo sapiens_hsa030101.95319820
12One carbon pool by folate_Homo sapiens_hsa006701.93801551
13Cell cycle_Homo sapiens_hsa041101.92536514
14Other glycan degradation_Homo sapiens_hsa005111.90930006
15Fanconi anemia pathway_Homo sapiens_hsa034601.86607582
16Biosynthesis of amino acids_Homo sapiens_hsa012301.81806941
17p53 signaling pathway_Homo sapiens_hsa041151.76726893
18Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.71016079
19Sulfur relay system_Homo sapiens_hsa041221.67514590
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.61618883
21mTOR signaling pathway_Homo sapiens_hsa041501.60654951
22Notch signaling pathway_Homo sapiens_hsa043301.59672676
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.51856995
24Sulfur metabolism_Homo sapiens_hsa009201.49358211
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.48921369
26Hippo signaling pathway_Homo sapiens_hsa043901.44819210
27Vibrio cholerae infection_Homo sapiens_hsa051101.44784994
28Arginine and proline metabolism_Homo sapiens_hsa003301.43705144
29Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.35951558
30Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.35745942
31Proteasome_Homo sapiens_hsa030501.33840618
32RNA polymerase_Homo sapiens_hsa030201.33199257
33Hedgehog signaling pathway_Homo sapiens_hsa043401.26096787
34Vitamin B6 metabolism_Homo sapiens_hsa007501.22039464
35Adherens junction_Homo sapiens_hsa045201.21220763
36Bladder cancer_Homo sapiens_hsa052191.18091717
37Folate biosynthesis_Homo sapiens_hsa007901.15512106
38Transcriptional misregulation in cancer_Homo sapiens_hsa052021.07055597
39Shigellosis_Homo sapiens_hsa051311.03678774
40Pyrimidine metabolism_Homo sapiens_hsa002401.02971562
41Collecting duct acid secretion_Homo sapiens_hsa049661.01312606
42TGF-beta signaling pathway_Homo sapiens_hsa043500.98928976
43Primary immunodeficiency_Homo sapiens_hsa053400.96058749
44Oocyte meiosis_Homo sapiens_hsa041140.95514896
45Circadian rhythm_Homo sapiens_hsa047100.94466553
46Non-small cell lung cancer_Homo sapiens_hsa052230.92707365
47Viral carcinogenesis_Homo sapiens_hsa052030.91642273
48Prion diseases_Homo sapiens_hsa050200.91350750
49Fructose and mannose metabolism_Homo sapiens_hsa000510.89119352
50Longevity regulating pathway - mammal_Homo sapiens_hsa042110.87916732
51RNA degradation_Homo sapiens_hsa030180.87356219
52Lysine degradation_Homo sapiens_hsa003100.86108283
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.86106439
54Basal cell carcinoma_Homo sapiens_hsa052170.83001494
55Colorectal cancer_Homo sapiens_hsa052100.81760833
56Alcoholism_Homo sapiens_hsa050340.81311105
57VEGF signaling pathway_Homo sapiens_hsa043700.81147441
58MicroRNAs in cancer_Homo sapiens_hsa052060.80803688
59Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.80645813
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.80288567
61Pancreatic cancer_Homo sapiens_hsa052120.76418613
62Wnt signaling pathway_Homo sapiens_hsa043100.76047610
63Epstein-Barr virus infection_Homo sapiens_hsa051690.74707825
64Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72692920
65Chronic myeloid leukemia_Homo sapiens_hsa052200.68356648
66Small cell lung cancer_Homo sapiens_hsa052220.68230523
67Thyroid cancer_Homo sapiens_hsa052160.67982255
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.67218966
69Acute myeloid leukemia_Homo sapiens_hsa052210.66275109
70Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.64832168
71Viral myocarditis_Homo sapiens_hsa054160.63503265
72Fatty acid metabolism_Homo sapiens_hsa012120.62512663
73Basal transcription factors_Homo sapiens_hsa030220.62103763
74Glioma_Homo sapiens_hsa052140.61803776
75Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.60672330
76Synaptic vesicle cycle_Homo sapiens_hsa047210.60395588
77Non-homologous end-joining_Homo sapiens_hsa034500.59424194
78Selenocompound metabolism_Homo sapiens_hsa004500.59093085
79Legionellosis_Homo sapiens_hsa051340.58486337
80Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.58110937
81Central carbon metabolism in cancer_Homo sapiens_hsa052300.57759833
82Cyanoamino acid metabolism_Homo sapiens_hsa004600.56078403
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54939034
84HTLV-I infection_Homo sapiens_hsa051660.54111374
85Herpes simplex infection_Homo sapiens_hsa051680.53419070
86Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52498663
87Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.52297598
88Neurotrophin signaling pathway_Homo sapiens_hsa047220.51297276
89Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.50864349
90Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.49682489
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48626681
92Purine metabolism_Homo sapiens_hsa002300.48546324
93Maturity onset diabetes of the young_Homo sapiens_hsa049500.48189345
94Tight junction_Homo sapiens_hsa045300.47603374
95Galactose metabolism_Homo sapiens_hsa000520.47596985
96Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43994776
97Phenylalanine metabolism_Homo sapiens_hsa003600.41013105
98Systemic lupus erythematosus_Homo sapiens_hsa053220.38836833
99Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.38673561
100Arginine biosynthesis_Homo sapiens_hsa002200.38561293
101Vitamin digestion and absorption_Homo sapiens_hsa049770.37492501
102Glutathione metabolism_Homo sapiens_hsa004800.37037208
103GnRH signaling pathway_Homo sapiens_hsa049120.36134619
104Hepatitis B_Homo sapiens_hsa051610.35644712
105Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.35460538
106Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.35373471
107Glycosaminoglycan degradation_Homo sapiens_hsa005310.35042681
108Renal cell carcinoma_Homo sapiens_hsa052110.34853215
109AMPK signaling pathway_Homo sapiens_hsa041520.34536206
110Pyruvate metabolism_Homo sapiens_hsa006200.33741117
111Pentose and glucuronate interconversions_Homo sapiens_hsa000400.33523512
112HIF-1 signaling pathway_Homo sapiens_hsa040660.31337957
113Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.31196683
114Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30069561
115ErbB signaling pathway_Homo sapiens_hsa040120.29847961
116Pentose phosphate pathway_Homo sapiens_hsa000300.29833234
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.29677578
118Proteoglycans in cancer_Homo sapiens_hsa052050.29464062
119Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.29441270
120Carbon metabolism_Homo sapiens_hsa012000.28707882
121Insulin signaling pathway_Homo sapiens_hsa049100.28342722
122Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28200069
123Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.27889694
124Glycerophospholipid metabolism_Homo sapiens_hsa005640.27858463
125Apoptosis_Homo sapiens_hsa042100.27114242
126Gap junction_Homo sapiens_hsa045400.23736257
127Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.23566562
128Endometrial cancer_Homo sapiens_hsa052130.22616631
129PI3K-Akt signaling pathway_Homo sapiens_hsa041510.21284343
130Pathways in cancer_Homo sapiens_hsa052000.20498263
131N-Glycan biosynthesis_Homo sapiens_hsa005100.19859730
132B cell receptor signaling pathway_Homo sapiens_hsa046620.17000492
133Choline metabolism in cancer_Homo sapiens_hsa052310.16625434
134Measles_Homo sapiens_hsa051620.16512415

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