BOLL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the DAZ gene family required for germ cell development. It encodes an RNA-binding protein which is more similar to Drosophila Boule than to human proteins encoded by genes DAZ (deleted in azoospermia) or DAZL (deleted in azoospermia-like). Loss of this gene function results in the absence of sperm in semen (azoospermia). Histological studies demonstrated that the primary defect is at the meiotic G2/M transition. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)9.57150498
2sperm-egg recognition (GO:0035036)9.34834867
3DNA methylation involved in gamete generation (GO:0043046)9.30291263
4acrosome assembly (GO:0001675)9.17841338
5binding of sperm to zona pellucida (GO:0007339)8.85979724
6multicellular organism reproduction (GO:0032504)8.64220798
7acrosome reaction (GO:0007340)8.58870308
8spermatid development (GO:0007286)8.49905732
9epithelial cilium movement (GO:0003351)8.45763137
10plasma membrane fusion (GO:0045026)8.42445057
11cell-cell recognition (GO:0009988)8.38204543
12motile cilium assembly (GO:0044458)8.13746634
13male meiosis I (GO:0007141)7.90630231
14cell wall macromolecule catabolic process (GO:0016998)7.66934917
15cell wall macromolecule metabolic process (GO:0044036)7.66934917
16epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.58941275
17cilium movement (GO:0003341)7.38677991
18chromosome organization involved in meiosis (GO:0070192)7.27005222
19reproduction (GO:0000003)7.12594286
20* meiotic nuclear division (GO:0007126)6.62270271
21regulation of cilium movement (GO:0003352)6.53280120
22meiosis I (GO:0007127)6.43618098
23single fertilization (GO:0007338)6.06190195
24regulation of meiosis I (GO:0060631)5.87020823
25fertilization (GO:0009566)5.75693024
26* spermatogenesis (GO:0007283)5.74814214
27* male gamete generation (GO:0048232)5.73111045
28negative regulation of inclusion body assembly (GO:0090084)5.59112145
29response to pheromone (GO:0019236)5.57005673
30germ cell development (GO:0007281)5.47230077
31meiotic cell cycle (GO:0051321)5.35139798
32* gamete generation (GO:0007276)5.26910540
33sperm capacitation (GO:0048240)5.25715222
34gene silencing by RNA (GO:0031047)5.25400674
35cellular process involved in reproduction in multicellular organism (GO:0022412)5.19151389
36ventricular system development (GO:0021591)4.87510989
37seminiferous tubule development (GO:0072520)4.72417507
38meiotic cell cycle process (GO:1903046)4.71794276
39microtubule depolymerization (GO:0007019)4.55135458
40regulation of inclusion body assembly (GO:0090083)4.43477488
41synapsis (GO:0007129)4.38656845
42protein localization to cilium (GO:0061512)4.35021710
43cellular ketone body metabolic process (GO:0046950)4.34488172
44genitalia morphogenesis (GO:0035112)4.31649324
45nuclear pore complex assembly (GO:0051292)4.31008459
46monoubiquitinated protein deubiquitination (GO:0035520)4.11735034
47organic cation transport (GO:0015695)4.09889940
48DNA deamination (GO:0045006)4.08895971
49* multicellular organismal reproductive process (GO:0048609)4.08374605
50protein K6-linked ubiquitination (GO:0085020)3.98741488
51DNA methylation (GO:0006306)3.91260407
52DNA alkylation (GO:0006305)3.91260407
53regulation of microtubule-based movement (GO:0060632)3.87247544
54cell recognition (GO:0008037)3.84207525
55ketone body metabolic process (GO:1902224)3.80950659
56intraciliary transport (GO:0042073)3.80724345
57microtubule severing (GO:0051013)3.67329313
58behavioral response to nicotine (GO:0035095)3.66700546
59gene silencing (GO:0016458)3.64293221
60nuclear pore organization (GO:0006999)3.63978902
61calcium ion-dependent exocytosis (GO:0017156)3.60446720
62regulation of protein polyubiquitination (GO:1902914)3.59764477
63negative regulation of telomere maintenance (GO:0032205)3.57877221
64DNA packaging (GO:0006323)3.57395252
65left/right pattern formation (GO:0060972)3.54115781
66sister chromatid cohesion (GO:0007062)3.49398167
67mannosylation (GO:0097502)3.45376398
68regulation of centriole replication (GO:0046599)3.42397607
69water-soluble vitamin biosynthetic process (GO:0042364)3.42300649
70RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.41963197
71mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.40241313
72mitochondrial respiratory chain complex I assembly (GO:0032981)3.40241313
73NADH dehydrogenase complex assembly (GO:0010257)3.40241313
74pore complex assembly (GO:0046931)3.39346132
75chaperone-mediated protein complex assembly (GO:0051131)3.36578319
76L-fucose metabolic process (GO:0042354)3.35710067
77L-fucose catabolic process (GO:0042355)3.35710067
78fucose catabolic process (GO:0019317)3.35710067
79mitotic sister chromatid cohesion (GO:0007064)3.34084670
80chromosome condensation (GO:0030261)3.29082901
81translesion synthesis (GO:0019985)3.28595677
82* multicellular organismal development (GO:0007275)3.28590205
83axoneme assembly (GO:0035082)3.27844380
84negative regulation of organelle assembly (GO:1902116)3.23447937
85regulation of histone H3-K9 methylation (GO:0051570)3.22659697
86spermatid nucleus differentiation (GO:0007289)3.19121635
87detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.18985061
88nucleotide transmembrane transport (GO:1901679)3.16252509
89reciprocal DNA recombination (GO:0035825)3.15834896
90reciprocal meiotic recombination (GO:0007131)3.15834896
91regulation of spindle checkpoint (GO:0090231)3.13564666
92respiratory chain complex IV assembly (GO:0008535)3.13551539
93phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.12354299
94protein complex biogenesis (GO:0070271)3.10914469
95kynurenine metabolic process (GO:0070189)3.10432238
96mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.10085374
97preassembly of GPI anchor in ER membrane (GO:0016254)3.07605646
98glycerophospholipid catabolic process (GO:0046475)3.06984383
99protein refolding (GO:0042026)3.06412490
100nucleus organization (GO:0006997)3.04732396
101protein polyglutamylation (GO:0018095)3.04707880
102centriole replication (GO:0007099)3.03921900
103negative regulation of DNA repair (GO:0045738)3.01758388
104DNA methylation or demethylation (GO:0044728)3.01522957
105detection of light stimulus involved in visual perception (GO:0050908)3.01506632
106detection of light stimulus involved in sensory perception (GO:0050962)3.01506632
107phosphatidylinositol acyl-chain remodeling (GO:0036149)3.00068300
108ATP synthesis coupled proton transport (GO:0015986)2.96997389
109energy coupled proton transport, down electrochemical gradient (GO:0015985)2.96997389
110nucleoside transmembrane transport (GO:1901642)2.96736054
111histone exchange (GO:0043486)2.96404282
112positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.93969807
113cilium morphogenesis (GO:0060271)2.89521048
114mitochondrial respiratory chain complex assembly (GO:0033108)2.89282531
115regulation of glucokinase activity (GO:0033131)2.89013689
116regulation of hexokinase activity (GO:1903299)2.89013689
117glycerol ether metabolic process (GO:0006662)2.88910717
118centriole assembly (GO:0098534)2.85406539
119microtubule-based movement (GO:0007018)2.85331197
120oogenesis (GO:0048477)2.84292559
121phosphatidylcholine acyl-chain remodeling (GO:0036151)2.83836002
122cilium organization (GO:0044782)2.83105669
123DNA replication-dependent nucleosome assembly (GO:0006335)2.82399897
124DNA replication-dependent nucleosome organization (GO:0034723)2.82399897
125sex differentiation (GO:0007548)2.82101316
126single strand break repair (GO:0000012)2.79736407
127heme transport (GO:0015886)2.79673519
128protein K11-linked deubiquitination (GO:0035871)2.79496209
129auditory receptor cell stereocilium organization (GO:0060088)2.78095275
130rRNA methylation (GO:0031167)2.76977463
131indolalkylamine metabolic process (GO:0006586)2.72266420
132positive regulation of meiosis (GO:0045836)2.71506594
133positive regulation of T-helper 1 type immune response (GO:0002827)2.71173312
134mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.66287782
135meiotic chromosome segregation (GO:0045132)2.66254627
136rRNA modification (GO:0000154)2.65812239
137cilium assembly (GO:0042384)2.65787856
138negative regulation of DNA-dependent DNA replication (GO:2000104)2.64580593
139regulation of nuclear cell cycle DNA replication (GO:0033262)2.63713238
140positive regulation of meiotic cell cycle (GO:0051446)2.62053373
141protein-cofactor linkage (GO:0018065)2.60885666
142phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.60633391
143tryptophan catabolic process (GO:0006569)2.57483113
144indole-containing compound catabolic process (GO:0042436)2.57483113
145indolalkylamine catabolic process (GO:0046218)2.57483113
146recombinational repair (GO:0000725)2.57300206
147cofactor transport (GO:0051181)2.57176825
148dopamine transport (GO:0015872)2.56837678
149cytidine deamination (GO:0009972)2.56299429
150cytidine metabolic process (GO:0046087)2.56299429
151cytidine catabolic process (GO:0006216)2.56299429
152double-strand break repair via homologous recombination (GO:0000724)2.56114270
153nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.55501440
154telomere maintenance via telomerase (GO:0007004)2.53316550
155platelet dense granule organization (GO:0060155)2.52386114
156establishment of protein localization to Golgi (GO:0072600)2.50287281
157positive regulation of mitochondrial fission (GO:0090141)2.50026724
158cytochrome complex assembly (GO:0017004)2.49232232
159tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.48697520
160RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.48697520
161protein neddylation (GO:0045116)2.48415788
162piRNA metabolic process (GO:0034587)13.5176735
163cilium or flagellum-dependent cell motility (GO:0001539)13.3496194
164fusion of sperm to egg plasma membrane (GO:0007342)11.1709321
165male meiosis (GO:0007140)10.7054113
166sperm motility (GO:0030317)10.6567197
167synaptonemal complex organization (GO:0070193)10.4119687
168synaptonemal complex assembly (GO:0007130)10.0860403

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.97744122
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.85581486
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.13459082
4GBX2_23144817_ChIP-Seq_PC3_Human2.72977579
5* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.66884059
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.31341609
7FUS_26573619_Chip-Seq_HEK293_Human2.22566647
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.19147482
9* FLI1_27457419_Chip-Seq_LIVER_Mouse2.17933850
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.16140533
11CTBP1_25329375_ChIP-Seq_LNCAP_Human2.09224401
12TAF15_26573619_Chip-Seq_HEK293_Human2.07840235
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.06148067
14RBPJ_22232070_ChIP-Seq_NCS_Mouse2.04889314
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.03158257
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse12.4770580
17ER_23166858_ChIP-Seq_MCF-7_Human1.99714559
18PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.99192164
19GATA1_26923725_Chip-Seq_HPCs_Mouse1.97458658
20SALL1_21062744_ChIP-ChIP_HESCs_Human1.97068405
21CTBP2_25329375_ChIP-Seq_LNCAP_Human1.94744490
22TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.94659477
23GABP_17652178_ChIP-ChIP_JURKAT_Human1.93848359
24IGF1R_20145208_ChIP-Seq_DFB_Human1.91769859
25EWS_26573619_Chip-Seq_HEK293_Human1.90783728
26ZFP57_27257070_Chip-Seq_ESCs_Mouse1.86631862
27* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.86270245
28TP53_22573176_ChIP-Seq_HFKS_Human1.80673295
29P300_19829295_ChIP-Seq_ESCs_Human1.80224276
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.79992157
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.79356428
32EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.77116535
33ELK4_26923725_Chip-Seq_MESODERM_Mouse1.68558925
34ZNF274_21170338_ChIP-Seq_K562_Hela1.67208355
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.61164047
36EST1_17652178_ChIP-ChIP_JURKAT_Human1.56382604
37UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.52692391
38WDR5_24793694_ChIP-Seq_LNCAP_Human1.50865024
39GATA3_21878914_ChIP-Seq_MCF-7_Human1.49606069
40ETV2_25802403_ChIP-Seq_MESCs_Mouse1.48781343
41MYC_18940864_ChIP-ChIP_HL60_Human1.48536779
42* SOX2_19829295_ChIP-Seq_ESCs_Human1.46787060
43* NANOG_19829295_ChIP-Seq_ESCs_Human1.46787060
44MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.45734211
45FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.45577725
46* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.44460049
47FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42236488
48VDR_23849224_ChIP-Seq_CD4+_Human1.39515260
49BMI1_23680149_ChIP-Seq_NPCS_Mouse1.38843476
50* NFE2_27457419_Chip-Seq_LIVER_Mouse1.38479336
51NCOR_22424771_ChIP-Seq_293T_Human1.38236388
52STAT1_17558387_ChIP-Seq_HELA_Human1.37688329
53IRF1_19129219_ChIP-ChIP_H3396_Human1.37105671
54BCAT_22108803_ChIP-Seq_LS180_Human1.35461839
55SMAD4_21741376_ChIP-Seq_EPCs_Human1.35284987
56ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.34159405
57KLF5_20875108_ChIP-Seq_MESCs_Mouse1.33959927
58TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.33438235
59AUTS2_25519132_ChIP-Seq_293T-REX_Human1.33336835
60KAP1_22055183_ChIP-Seq_ESCs_Mouse1.33064882
61HOXB7_26014856_ChIP-Seq_BT474_Human1.32037969
62STAT3_23295773_ChIP-Seq_U87_Human1.31137939
63AR_25329375_ChIP-Seq_VCAP_Human1.29801079
64GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.28865239
65STAT6_21828071_ChIP-Seq_BEAS2B_Human1.28414889
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27388212
67NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.27322555
68SOX2_22085726_ChIP-Seq_NPCs_Mouse1.26614291
69* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.25746250
70GATA3_21867929_ChIP-Seq_CD8_Mouse1.25537420
71SMAD4_21799915_ChIP-Seq_A2780_Human1.24603996
72TCF4_22108803_ChIP-Seq_LS180_Human1.24419512
73CBP_20019798_ChIP-Seq_JUKART_Human1.22927039
74IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.22927039
75FOXA1_21572438_ChIP-Seq_LNCaP_Human1.22206019
76TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22171110
77KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.21636029
78GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.21586931
79TAL1_26923725_Chip-Seq_HPCs_Mouse1.20783390
80NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.20451738
81AR_20517297_ChIP-Seq_VCAP_Human1.20403634
82AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19666499
83VDR_22108803_ChIP-Seq_LS180_Human1.19038450
84EGR1_23403033_ChIP-Seq_LIVER_Mouse1.18501605
85FOXH1_21741376_ChIP-Seq_EPCs_Human1.18362772
86RNF2_27304074_Chip-Seq_NSC_Mouse1.17264813
87SMAD3_21741376_ChIP-Seq_EPCs_Human1.16898332
88MYC_19829295_ChIP-Seq_ESCs_Human1.16356227
89CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.15316194
90PHF8_20622853_ChIP-Seq_HELA_Human1.15042461
91ERA_21632823_ChIP-Seq_H3396_Human1.14842686
92* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14618833
93RUNX2_22187159_ChIP-Seq_PCA_Human1.14005296
94* SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.13456071
95GATA3_21867929_ChIP-Seq_TH1_Mouse1.12357509
96ETV1_20927104_ChIP-Seq_GIST48_Human1.11510411
97RBPJ_21746931_ChIP-Seq_IB4_Human1.10006792
98TAF2_19829295_ChIP-Seq_ESCs_Human1.09929677
99SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.09788199
100SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.08534506
101RUNX1_26923725_Chip-Seq_HPCs_Mouse1.08241871
102OCT4_20526341_ChIP-Seq_ESCs_Human1.08110565
103NANOG_20526341_ChIP-Seq_ESCs_Human1.07836618
104GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07520795
105FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07036703
106NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05414293
107* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04787158
108NFYB_21822215_ChIP-Seq_K562_Human1.04750331
109PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04353246
110JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.04147850
111CDX2_22108803_ChIP-Seq_LS180_Human1.03542157
112CBX2_22325352_ChIP-Seq_293T-Rex_Human1.03080110
113HTT_18923047_ChIP-ChIP_STHdh_Human1.02590475
114REST_21632747_ChIP-Seq_MESCs_Mouse1.00583451
115GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.00295004
116NOTCH1_21737748_ChIP-Seq_TLL_Human1.00229736
117ERG_20517297_ChIP-Seq_VCAP_Human0.99276226
118* CRX_20693478_ChIP-Seq_RETINA_Mouse0.98973748
119KDM2B_26808549_Chip-Seq_REH_Human0.97882004
120PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97259295
121P53_21459846_ChIP-Seq_SAOS-2_Human0.96316965
122CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95807236
123YY1_22570637_ChIP-Seq_MALME-3M_Human0.95550464
124* OCT4_18555785_Chip-Seq_ESCs_Mouse0.95479272
125E2F7_22180533_ChIP-Seq_HELA_Human0.95326591
126LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.95043579
127TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93702526
128POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.93702526
129MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93564002
130E2F4_17652178_ChIP-ChIP_JURKAT_Human0.93546512
131* EZH2_27294783_Chip-Seq_NPCs_Mouse0.93154531
132* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.91427161
133ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.90396410
134FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.90167023
135FLI1_21867929_ChIP-Seq_TH2_Mouse0.89992119
136SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89336035
137LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.88880884
138RXRA_24833708_ChIP-Seq_LIVER_Mouse0.88712909
139* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88051875
140SOX2_21211035_ChIP-Seq_LN229_Human0.87803141
141CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.87356326
142* SPI1_26923725_Chip-Seq_HPCs_Mouse0.87170227
143CBX2_27304074_Chip-Seq_ESCs_Mouse0.86614273
144MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.86588646
145PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.86365435
146FLI1_21867929_ChIP-Seq_CD8_Mouse0.86261523
147* NANOG_18555785_Chip-Seq_ESCs_Mouse0.86040405
148* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.85450079
149* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.85301725
150FOXA1_27270436_Chip-Seq_PROSTATE_Human0.84640171
151FOXA1_25329375_ChIP-Seq_VCAP_Human0.84640171
152* P53_22387025_ChIP-Seq_ESCs_Mouse0.84394532
153TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84242656
154FOXM1_23109430_ChIP-Seq_U2OS_Human0.83902833
155* STAT3_18555785_Chip-Seq_ESCs_Mouse0.83834393
156* KLF4_18555785_Chip-Seq_ESCs_Mouse0.82412681
157* P300_18555785_Chip-Seq_ESCs_Mouse0.82387255
158ESET_19884257_ChIP-Seq_ESCs_Mouse0.82307312
159ETS1_22383799_ChIP-Seq_G1ME_Mouse0.81800981
160PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.81614365
161* ESRRB_18555785_Chip-Seq_ESCs_Mouse0.81556650
162EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.81454606
163GF1_26923725_Chip-Seq_HPCs_Mouse0.81013537
164RARA_24833708_ChIP-Seq_LIVER_Mouse0.81003547
165GATA3_26560356_Chip-Seq_TH1_Human0.80548144
166CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80159417
167PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80072602
168RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.79047134
169TCF4_23295773_ChIP-Seq_U87_Human0.78107933
170* MYCN_18555785_ChIP-Seq_MESCs_Mouse0.77993153

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation7.39878586
2* MP0003698_abnormal_male_reproductive5.68362231
3* MP0001929_abnormal_gametogenesis5.60581782
4* MP0002210_abnormal_sex_determination4.52992638
5* MP0001145_abnormal_male_reproductive3.77209528
6MP0003195_calcinosis3.40770647
7MP0008057_abnormal_DNA_replication3.37185241
8* MP0000653_abnormal_sex_gland3.27262180
9* MP0002161_abnormal_fertility/fecundity3.06478476
10MP0002837_dystrophic_cardiac_calcinosis2.47514730
11MP0002160_abnormal_reproductive_system2.37448624
12MP0005551_abnormal_eye_electrophysiolog2.36848917
13MP0008058_abnormal_DNA_repair2.31698099
14MP0010094_abnormal_chromosome_stability2.31022327
15MP0008875_abnormal_xenobiotic_pharmacok2.27132356
16MP0008995_early_reproductive_senescence2.27071994
17MP0002653_abnormal_ependyma_morphology2.21226592
18MP0005645_abnormal_hypothalamus_physiol2.18596840
19MP0004145_abnormal_muscle_electrophysio2.17364938
20MP0006072_abnormal_retinal_apoptosis2.14410875
21MP0001968_abnormal_touch/_nociception2.03253651
22MP0003786_premature_aging2.02480757
23MP0005410_abnormal_fertilization12.7277493
24MP0000372_irregular_coat_pigmentation1.94033661
25MP0008872_abnormal_physiological_respon1.82038059
26MP0002102_abnormal_ear_morphology1.78251851
27MP0008007_abnormal_cellular_replicative1.77375607
28MP0002876_abnormal_thyroid_physiology1.75790420
29MP0004142_abnormal_muscle_tone1.60589031
30MP0001485_abnormal_pinna_reflex1.60051191
31MP0002736_abnormal_nociception_after1.59647555
32MP0009745_abnormal_behavioral_response1.55966196
33MP0005646_abnormal_pituitary_gland1.54661172
34MP0005623_abnormal_meninges_morphology1.53270471
35MP0004147_increased_porphyrin_level1.51692841
36MP0002272_abnormal_nervous_system1.50896570
37MP0001529_abnormal_vocalization1.50235173
38MP0004808_abnormal_hematopoietic_stem1.49440869
39MP0004885_abnormal_endolymph1.46985271
40MP0003137_abnormal_impulse_conducting1.46150360
41MP0003718_maternal_effect1.42872105
42MP0003646_muscle_fatigue1.42638434
43MP0004742_abnormal_vestibular_system1.36904279
44MP0005647_abnormal_sex_gland1.35946507
45MP0001486_abnormal_startle_reflex1.35326539
46MP0003111_abnormal_nucleus_morphology1.27624973
47MP0005389_reproductive_system_phenotype1.27585021
48MP0006035_abnormal_mitochondrial_morpho1.26247180
49MP0006276_abnormal_autonomic_nervous1.22805236
50MP0002938_white_spotting1.21216917
51MP0004782_abnormal_surfactant_physiolog1.19433576
52MP0000631_abnormal_neuroendocrine_gland1.19368363
53MP0003077_abnormal_cell_cycle1.14843533
54MP0001501_abnormal_sleep_pattern1.12705987
55MP0005670_abnormal_white_adipose1.09245704
56MP0005174_abnormal_tail_pigmentation1.09063359
57MP0005332_abnormal_amino_acid1.09050085
58MP0002138_abnormal_hepatobiliary_system1.08367102
59MP0002254_reproductive_system_inflammat1.07437378
60MP0006292_abnormal_olfactory_placode1.06529306
61MP0002332_abnormal_exercise_endurance1.06320025
62MP0002572_abnormal_emotion/affect_behav1.05888440
63MP0002282_abnormal_trachea_morphology1.04857230
64MP0001905_abnormal_dopamine_level1.04679351
65MP0000383_abnormal_hair_follicle1.02508017
66MP0003880_abnormal_central_pattern1.01048608
67MP0005075_abnormal_melanosome_morpholog1.00444028
68MP0002638_abnormal_pupillary_reflex0.99839480
69MP0005266_abnormal_metabolism0.99461383
70MP0010307_abnormal_tumor_latency0.98606354
71MP0003136_yellow_coat_color0.98176278
72MP0002095_abnormal_skin_pigmentation0.96434485
73MP0000749_muscle_degeneration0.95963595
74MP0001119_abnormal_female_reproductive0.95791189
75MP0004215_abnormal_myocardial_fiber0.94537633
76MP0004043_abnormal_pH_regulation0.93570319
77MP0002229_neurodegeneration0.92408279
78MP0002067_abnormal_sensory_capabilities0.91903049
79MP0005084_abnormal_gallbladder_morpholo0.91362321
80MP0002557_abnormal_social/conspecific_i0.89914063
81MP0003787_abnormal_imprinting0.89253609
82MP0001545_abnormal_hematopoietic_system0.88956225
83MP0005397_hematopoietic_system_phenotyp0.88956225
84MP0001873_stomach_inflammation0.87212779
85MP0001440_abnormal_grooming_behavior0.86414334
86MP0002064_seizures0.85503282
87MP0003878_abnormal_ear_physiology0.85126002
88MP0005377_hearing/vestibular/ear_phenot0.85126002
89MP0000647_abnormal_sebaceous_gland0.84415304
90MP0005379_endocrine/exocrine_gland_phen0.83979668
91MP0001764_abnormal_homeostasis0.82353092
92MP0003806_abnormal_nucleotide_metabolis0.82202521
93MP0004085_abnormal_heartbeat0.81489096
94MP0001970_abnormal_pain_threshold0.76978185
95MP0002909_abnormal_adrenal_gland0.76019573
96MP0002693_abnormal_pancreas_physiology0.75163969
97MP0003638_abnormal_response/metabolism_0.75123667
98MP0003011_delayed_dark_adaptation0.74373728
99MP0002733_abnormal_thermal_nociception0.74371420
100MP0002751_abnormal_autonomic_nervous0.73925750
101MP0004133_heterotaxia0.73576381
102MP0003699_abnormal_female_reproductive0.73339678
103MP0004484_altered_response_of0.72300754
104MP0010386_abnormal_urinary_bladder0.71723105
105MP0005195_abnormal_posterior_eye0.71145207
106MP0004134_abnormal_chest_morphology0.71111719
107MP0001730_embryonic_growth_arrest0.70665132
108MP0003763_abnormal_thymus_physiology0.69442265
109MP0004957_abnormal_blastocyst_morpholog0.69379114
110MP0003693_abnormal_embryo_hatching0.69136028
111MP0009278_abnormal_bone_marrow0.67594477
112MP0001986_abnormal_taste_sensitivity0.64478091
113MP0003943_abnormal_hepatobiliary_system0.63892630
114MP0000313_abnormal_cell_death0.63718683
115MP0000358_abnormal_cell_content/0.59202407
116MP0004233_abnormal_muscle_weight0.57953588
117MP0003115_abnormal_respiratory_system0.57119053
118MP0001293_anophthalmia0.55636971
119MP0008932_abnormal_embryonic_tissue0.55523024
120MP0001765_abnormal_ion_homeostasis0.55050304
121MP0001984_abnormal_olfaction0.52793497
122MP0003936_abnormal_reproductive_system0.52355228
123MP0000427_abnormal_hair_cycle0.52066272
124MP0002405_respiratory_system_inflammati0.47137338
125MP0002084_abnormal_developmental_patter0.46308405
126MP0003045_fibrosis0.45447652
127MP0002928_abnormal_bile_duct0.45220209
128MP0010352_gastrointestinal_tract_polyps0.44632408
129MP0000703_abnormal_thymus_morphology0.43489573
130MP0002019_abnormal_tumor_incidence0.40866603
131MP0001697_abnormal_embryo_size0.40527035
132MP0000685_abnormal_immune_system0.40481271
133MP0001851_eye_inflammation0.38482148
134MP0001835_abnormal_antigen_presentation0.38323052
135MP0000569_abnormal_digit_pigmentation0.37870564
136MP0002398_abnormal_bone_marrow0.37068448
137MP0005391_vision/eye_phenotype0.36598096
138MP0001727_abnormal_embryo_implantation0.35269238
139MP0001661_extended_life_span0.33932930
140MP0001672_abnormal_embryogenesis/_devel0.32769203
141MP0005380_embryogenesis_phenotype0.32769203
142MP0002080_prenatal_lethality0.32590510
143MP0004197_abnormal_fetal_growth/weight/0.32074904
144MP0002092_abnormal_eye_morphology0.32033018
145MP0001849_ear_inflammation0.31465022
146MP0002085_abnormal_embryonic_tissue0.30941739
147MP0000350_abnormal_cell_proliferation0.30409343
148MP0005253_abnormal_eye_physiology0.30218565
149MP0006036_abnormal_mitochondrial_physio0.29768334
150MP0002234_abnormal_pharynx_morphology0.29486860
151MP0000689_abnormal_spleen_morphology0.29402040
152MP0005076_abnormal_cell_differentiation0.29259559
153MP0005666_abnormal_adipose_tissue0.28355962
154MP0002132_abnormal_respiratory_system0.28208359
155MP0003866_abnormal_defecation0.27810360
156MP0009115_abnormal_fat_cell0.27757316
157MP0001919_abnormal_reproductive_system0.26971912
158MP0003861_abnormal_nervous_system0.26831464
159MP0001324_abnormal_eye_pigmentation0.26686157
160MP0009046_muscle_twitch0.25279514
161MP0005671_abnormal_response_to0.24625960
162MP0003984_embryonic_growth_retardation0.22580468
163MP0003123_paternal_imprinting0.22475620
164MP0003890_abnormal_embryonic-extraembry0.21517945
165MP0003950_abnormal_plasma_membrane0.21515303
166MP0004036_abnormal_muscle_relaxation0.21332727
167MP0002970_abnormal_white_adipose0.20429626
168MP0001853_heart_inflammation0.20044830
169MP0005636_abnormal_mineral_homeostasis0.19710298
170MP0002088_abnormal_embryonic_growth/wei0.19496677
171MP0002009_preneoplasia0.19048523
172MP0003252_abnormal_bile_duct0.18649659

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)8.55762861
2Abnormal respiratory motile cilium morphology (HP:0005938)8.05747688
3Abnormal respiratory epithelium morphology (HP:0012253)8.05747688
4Rhinitis (HP:0012384)7.40735609
5Abnormal ciliary motility (HP:0012262)6.75335242
6Chronic bronchitis (HP:0004469)6.67345528
7Nasal polyposis (HP:0100582)6.28681246
8Infertility (HP:0000789)5.91261840
9Abnormality of the nasal mucosa (HP:0000433)5.12101912
10Nephronophthisis (HP:0000090)4.75972161
11Bronchiectasis (HP:0002110)4.54081191
12Abnormality of the lower motor neuron (HP:0002366)4.52266620
13Gonadotropin excess (HP:0000837)4.47872634
14Bronchitis (HP:0012387)4.41057430
15Abnormal spermatogenesis (HP:0008669)4.17018415
16Azoospermia (HP:0000027)3.86971578
17Pancreatic cysts (HP:0001737)3.72005631
18Abnormality of the renal medulla (HP:0100957)3.61204078
19Amyotrophic lateral sclerosis (HP:0007354)3.56719342
20Fibular hypoplasia (HP:0003038)3.51697398
21Chronic hepatic failure (HP:0100626)3.47493645
22Attenuation of retinal blood vessels (HP:0007843)3.34606318
23Type II lissencephaly (HP:0007260)3.31836371
24Congenital stationary night blindness (HP:0007642)3.24133953
25Tubulointerstitial nephritis (HP:0001970)3.21311990
26Degeneration of anterior horn cells (HP:0002398)3.11968045
27Abnormality of the anterior horn cell (HP:0006802)3.11968045
28Recurrent otitis media (HP:0000403)3.09421929
29Recurrent sinusitis (HP:0011108)3.07163226
30Male infertility (HP:0003251)3.07153154
31Abnormality of midbrain morphology (HP:0002418)3.04310439
32Molar tooth sign on MRI (HP:0002419)3.04310439
3311 pairs of ribs (HP:0000878)3.00780647
34Recurrent bronchitis (HP:0002837)2.90198697
35Decreased electroretinogram (ERG) amplitude (HP:0000654)2.90134924
36Large for gestational age (HP:0001520)2.88801910
37Upper motor neuron abnormality (HP:0002127)2.88592664
38Type I transferrin isoform profile (HP:0003642)2.77383265
39Acute necrotizing encephalopathy (HP:0006965)2.71922961
40Mitochondrial inheritance (HP:0001427)2.64855386
41Impaired proprioception (HP:0010831)2.64313789
42Increased CSF lactate (HP:0002490)2.60210992
43Abnormality of macular pigmentation (HP:0008002)2.59890601
44Cerebellar dysplasia (HP:0007033)2.59326162
45Tubular atrophy (HP:0000092)2.56144259
46Postaxial foot polydactyly (HP:0001830)2.53947472
47Inability to walk (HP:0002540)2.52671061
48Tubulointerstitial abnormality (HP:0001969)2.52257495
49Impulsivity (HP:0100710)2.49869083
50Acute encephalopathy (HP:0006846)2.46651056
51Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.44637663
52Abnormal protein N-linked glycosylation (HP:0012347)2.44637663
53Abnormal protein glycosylation (HP:0012346)2.44637663
54Abnormal glycosylation (HP:0012345)2.44637663
55Abolished electroretinogram (ERG) (HP:0000550)2.43041663
56Abnormality of the labia minora (HP:0012880)2.41857548
57Medial flaring of the eyebrow (HP:0010747)2.38444621
58Progressive inability to walk (HP:0002505)2.35580970
59Supernumerary spleens (HP:0009799)2.34893067
60Optic nerve hypoplasia (HP:0000609)2.29542949
61Hyperventilation (HP:0002883)2.28483461
62Retinal dysplasia (HP:0007973)2.27878552
633-Methylglutaconic aciduria (HP:0003535)2.27536165
64Stage 5 chronic kidney disease (HP:0003774)2.24515575
65Progressive macrocephaly (HP:0004481)2.23929141
66Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.22408357
67Abnormality of alanine metabolism (HP:0010916)2.22408357
68Hyperalaninemia (HP:0003348)2.22408357
69Abnormal mitochondria in muscle tissue (HP:0008316)2.21969093
70Lipid accumulation in hepatocytes (HP:0006561)2.21141502
71Hypothermia (HP:0002045)2.20671972
72Abnormal rod and cone electroretinograms (HP:0008323)2.20024663
73Aplasia/Hypoplasia of the fibula (HP:0006492)2.18139648
74Aplasia/Hypoplasia of the tibia (HP:0005772)2.18026707
75Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.17562090
76Hepatocellular necrosis (HP:0001404)2.17337452
77Hepatic necrosis (HP:0002605)2.13237962
78Increased hepatocellular lipid droplets (HP:0006565)2.11290543
79Decreased central vision (HP:0007663)2.10965770
80Bony spicule pigmentary retinopathy (HP:0007737)2.10535258
81Facial cleft (HP:0002006)2.10264284
82Optic disc pallor (HP:0000543)2.08573415
83Congenital hepatic fibrosis (HP:0002612)2.07389807
84Sclerocornea (HP:0000647)2.06689593
85Hypoplasia of the capital femoral epiphysis (HP:0003090)2.04651103
86Methylmalonic aciduria (HP:0012120)2.03999862
87Abnormality of the renal cortex (HP:0011035)2.03121367
88Short ribs (HP:0000773)2.03031618
89Selective tooth agenesis (HP:0001592)2.02513720
90Methylmalonic acidemia (HP:0002912)2.01038809
91Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.3939325
92Dynein arm defect of respiratory motile cilia (HP:0012255)11.5153494
93Absent/shortened dynein arms (HP:0200106)11.5153494
94Severe visual impairment (HP:0001141)1.99938721
95Decreased circulating renin level (HP:0003351)1.99850948
96Renal cortical cysts (HP:0000803)1.99337107
97Polyuria (HP:0000103)1.97077823
98Stomach cancer (HP:0012126)1.96074908
99Renal dysplasia (HP:0000110)1.96057655
100Progressive cerebellar ataxia (HP:0002073)1.96037303
101Hyperglycinuria (HP:0003108)1.95994818
102Pendular nystagmus (HP:0012043)1.94564650
103Oculomotor apraxia (HP:0000657)1.93257223
104Renal Fanconi syndrome (HP:0001994)1.92469842
105Aplasia/Hypoplasia of the fovea (HP:0008060)1.90114559
106Hypoplasia of the fovea (HP:0007750)1.90114559
107Amelogenesis imperfecta (HP:0000705)1.89244744
108Colon cancer (HP:0003003)1.88020857
109Short tibia (HP:0005736)1.87900214
110Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.85123248
111Lissencephaly (HP:0001339)1.84568615
112Anencephaly (HP:0002323)1.84533667
113Tubulointerstitial fibrosis (HP:0005576)1.84086712
114Hyperglycinemia (HP:0002154)1.83816367
115Gait imbalance (HP:0002141)1.83705244
116Congenital primary aphakia (HP:0007707)1.83469418
117Atrophy/Degeneration involving motor neurons (HP:0007373)1.82509417
118Stomatitis (HP:0010280)1.81892616
119Increased serum lactate (HP:0002151)1.79730010
120Congenital sensorineural hearing impairment (HP:0008527)1.79623326
121Intestinal atresia (HP:0011100)1.79568425
122Hypomagnesemia (HP:0002917)1.79441505
123Median cleft lip (HP:0000161)1.79001170
124Exertional dyspnea (HP:0002875)1.77260231
125Abnormality of the ileum (HP:0001549)1.76097664
126Increased corneal curvature (HP:0100692)1.75871337
127Keratoconus (HP:0000563)1.75871337
128Heterotopia (HP:0002282)1.75309801
129Absent frontal sinuses (HP:0002688)1.75032412
130Cerebral edema (HP:0002181)1.74956437
131Abnormality of urine glucose concentration (HP:0011016)1.74565270
132Glycosuria (HP:0003076)1.74565270
133Lactic acidosis (HP:0003128)1.74425267
134Genital tract atresia (HP:0001827)1.74409972
135Aplasia/Hypoplasia of the uvula (HP:0010293)1.73961306
136Abnormality of the dental root (HP:0006486)1.73919813
137Taurodontia (HP:0000679)1.73919813
138Abnormality of permanent molar morphology (HP:0011071)1.73919813
139Short thorax (HP:0010306)1.73679737
140Occipital encephalocele (HP:0002085)1.73302744
141Chronic sinusitis (HP:0011109)1.69258985
142Abnormality of dentin (HP:0010299)1.67984865
143Conjunctival telangiectasia (HP:0000524)1.67702531
144Polydipsia (HP:0001959)1.67219965
145Abnormal drinking behavior (HP:0030082)1.67219965
146Postaxial hand polydactyly (HP:0001162)1.65657570
147Breast carcinoma (HP:0003002)1.61480732
148Abnormality of molar (HP:0011077)1.60924593
149Abnormality of molar morphology (HP:0011070)1.60924593
150Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.59983483
151Absent epiphyses (HP:0010577)1.59983483
152Large eyes (HP:0001090)1.56917845
153Cystic liver disease (HP:0006706)1.54767725
154True hermaphroditism (HP:0010459)1.54610879
155Missing ribs (HP:0000921)1.54419250
156Bell-shaped thorax (HP:0001591)1.54109245
157Pancreatic fibrosis (HP:0100732)1.52828553
158Abnormality of the dental pulp (HP:0006479)1.52701187
159Microglossia (HP:0000171)1.47393811
160Abnormality of the vasculature of the conjunctiva (HP:0008054)1.46888639
161Spastic tetraparesis (HP:0001285)1.45087750
162Abnormal biliary tract physiology (HP:0012439)1.43744436
163Bile duct proliferation (HP:0001408)1.43744436
164Aplasia/Hypoplasia of the tongue (HP:0010295)1.42970576
165Sloping forehead (HP:0000340)1.42079518
166Ectopic kidney (HP:0000086)1.41204172
167Nephropathy (HP:0000112)1.40272436
168Decreased motor nerve conduction velocity (HP:0003431)1.39195887
169Broad distal phalanx of finger (HP:0009836)1.38213372
170J-shaped sella turcica (HP:0002680)1.36374779
171Gaze-evoked nystagmus (HP:0000640)1.35900363
172Abnormality of ocular smooth pursuit (HP:0000617)1.33098145
173Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.31219172
174Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.30991487
175Hypoplasia of the radius (HP:0002984)1.30629400
176Nephroblastoma (Wilms tumor) (HP:0002667)1.29529564
177Deformed sella turcica (HP:0002681)1.29439600
178Abnormality of renal excretion (HP:0011036)1.27232368
179Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.26547927
180Male pseudohermaphroditism (HP:0000037)1.23086869

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.80032098
2PDK48.80032098
3PDK25.65695079
4TESK14.56565935
5PRKD33.57858612
6FRK3.55580174
7MAP4K23.25474094
8ICK3.03703713
9TLK12.99992949
10ZAK2.67527499
11CDC72.65409232
12TAOK32.65339955
13ADRBK22.63820014
14NEK22.39528026
15PTK2B2.11808618
16PNCK2.11389705
17INSRR2.10514501
18OBSCN2.07900060
19NUAK12.01549912
20WNK41.99036286
21OXSR11.95807349
22STK391.88632621
23GRK11.79284968
24PHKG21.71509169
25PHKG11.71509169
26ACVR1B1.63851840
27PLK21.50408566
28BCKDK1.47262169
29TRIM281.34984936
30CASK1.34095603
31PAK31.34084536
32CCNB11.25951773
33WEE11.23519926
34TIE11.18280474
35STK381.11602036
36CDK121.08119421
37MST41.07979377
38IRAK11.07826283
39MAPK131.06860140
40CDK191.06319028
41VRK11.05780348
42CSNK1G11.05119540
43CSNK1G31.03825804
44CSNK1G21.00582304
45PASK1.00012180
46NEK10.99936611
47ATR0.95618135
48WNK10.94831055
49DYRK30.93631940
50TYRO30.92253081
51MET0.91303991
52MKNK10.89058738
53STK30.87920410
54TTK0.87143485
55MKNK20.87031444
56DAPK20.86362174
57ADRBK10.85236539
58DYRK1B0.83729720
59TSSK60.82027269
60PDK10.81200001
61MAPK150.80963555
62TAF10.76879709
63PRKCE0.75897969
64MAP2K70.74820324
65CHEK10.72820679
66TNK20.71769510
67FGFR20.71325375
68CSNK1A1L0.70350783
69IKBKB0.69066851
70CDK80.68896764
71PLK40.68634777
72VRK20.66928572
73TNIK0.66821331
74PIK3CA0.66171939
75CAMKK20.66015850
76MUSK0.65231511
77PLK30.64622227
78DYRK20.63043692
79PRKCI0.62869078
80PINK10.61525136
81CHEK20.60664216
82CAMK2A0.59530111
83ATM0.58696170
84ERBB30.57815158
85PIK3CG0.57693217
86PLK10.57032226
87FER0.55350882
88FGFR10.51226296
89BMPR1B0.50773648
90CSNK1A10.50287978
91MAP2K10.49962158
92SRPK10.49409493
93PRKACA0.48423230
94EEF2K0.47878405
95TESK20.47235806
96EIF2AK10.46808851
97PKN10.43346127
98IRAK20.41020675
99CAMK10.40950614
100PRKG10.39735696
101STK110.38006087
102TEC0.36421946
103CAMK1G0.35801611
104STK160.35572059
105LIMK10.34255323
106RPS6KB10.34216199
107MAP4K10.33517912
108GRK60.32621820
109TXK0.32420305
110MTOR0.32101609
111BUB10.31923035
112PRKACB0.31651690
113RPS6KA50.30526842
114NTRK30.29957552
115FLT30.29588682
116BRSK20.28693420
117PIM10.26383527
118MAP2K60.24169608
119ZAP700.23599589
120BRD40.21704686
121CDK30.19825697
122CDK20.19658353
123CSNK2A10.17098710
124EIF2AK30.16887462
125STK38L0.16429357
126CDK40.16005237
127CDK10.15805192
128WNK30.15770605
129STK40.14733287
130PDPK10.13332861
131CDK70.13072169
132LMTK20.11989376
133PAK10.11462678
134PRKAA10.11089053
135AURKB0.10809593
136CSNK2A20.09498047
137MAPK80.09410404
138GSK3B0.08994707
139PRKDC0.08640166
140MARK30.08168235
141BRSK10.07847491
142CSNK1D0.07436595
143NTRK20.07075800
144CLK10.06179935
145NLK0.05641919
146STK100.05401372
147PRKD20.05274863
148RPS6KA10.04006022
149PAK20.03454466
150MELK0.03412190
151PRKCQ0.03227387
152RIPK40.02887006
153CSF1R0.02699711
154CSK0.02557186
155MAP3K40.02481654
156RPS6KA60.02113191
157MAPK10.01450463
158TGFBR10.00850827
159CDK90.00600275
160YES1-0.0233598
161TBK1-0.0206475
162PRKCG-0.0158081
163MAPKAPK5-0.0094702
164AURKA-0.0072005
165MAPK10-0.0035129
166MAP3K5-0.0033212
167MAPK14-0.0009608

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal transcription factors_Homo sapiens_hsa030224.09976831
2Vitamin B6 metabolism_Homo sapiens_hsa007503.96382738
3Fanconi anemia pathway_Homo sapiens_hsa034603.63619888
4Pyruvate metabolism_Homo sapiens_hsa006203.37533814
5Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.07798332
6Selenocompound metabolism_Homo sapiens_hsa004503.01130744
7Dorso-ventral axis formation_Homo sapiens_hsa043202.92776324
8Phototransduction_Homo sapiens_hsa047442.85653146
9Nitrogen metabolism_Homo sapiens_hsa009102.75298513
10Oxidative phosphorylation_Homo sapiens_hsa001902.64428746
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.64076470
12Fatty acid biosynthesis_Homo sapiens_hsa000612.52446022
13Homologous recombination_Homo sapiens_hsa034402.47830683
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.32620535
15Glucagon signaling pathway_Homo sapiens_hsa049222.29429010
16mRNA surveillance pathway_Homo sapiens_hsa030152.29373265
17Linoleic acid metabolism_Homo sapiens_hsa005912.29129770
18Propanoate metabolism_Homo sapiens_hsa006402.28141686
19RNA transport_Homo sapiens_hsa030132.24060778
20Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.21360354
21Oocyte meiosis_Homo sapiens_hsa041142.15504768
22Caffeine metabolism_Homo sapiens_hsa002322.11323617
23Parkinsons disease_Homo sapiens_hsa050122.03564370
24Pentose phosphate pathway_Homo sapiens_hsa000301.98386378
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.95480051
26Antigen processing and presentation_Homo sapiens_hsa046121.89609477
27Butanoate metabolism_Homo sapiens_hsa006501.88690889
28Maturity onset diabetes of the young_Homo sapiens_hsa049501.85297823
29Protein export_Homo sapiens_hsa030601.84537017
30DNA replication_Homo sapiens_hsa030301.83208601
31One carbon pool by folate_Homo sapiens_hsa006701.82111203
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.80083867
33Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.75012856
34Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.70628376
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.68225903
36Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.65148341
37Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.65092328
38Tryptophan metabolism_Homo sapiens_hsa003801.60710035
39Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.59386624
40Huntingtons disease_Homo sapiens_hsa050161.59268411
41RNA degradation_Homo sapiens_hsa030181.53538961
42Glycerolipid metabolism_Homo sapiens_hsa005611.49060601
43Cell cycle_Homo sapiens_hsa041101.47679185
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.42633975
45Purine metabolism_Homo sapiens_hsa002301.34430385
46Mismatch repair_Homo sapiens_hsa034301.32919174
47Nucleotide excision repair_Homo sapiens_hsa034201.32569238
48Spliceosome_Homo sapiens_hsa030401.32428677
49Alzheimers disease_Homo sapiens_hsa050101.31219259
50Olfactory transduction_Homo sapiens_hsa047401.23108529
51Folate biosynthesis_Homo sapiens_hsa007901.22852668
52Non-homologous end-joining_Homo sapiens_hsa034501.22064574
53Cysteine and methionine metabolism_Homo sapiens_hsa002701.16712462
54Carbohydrate digestion and absorption_Homo sapiens_hsa049731.16410856
55Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.13014993
56Nicotine addiction_Homo sapiens_hsa050331.11987319
57Peroxisome_Homo sapiens_hsa041461.11741362
58Regulation of autophagy_Homo sapiens_hsa041401.11330658
59Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.10502264
60Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.10191940
61Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.09697112
62Base excision repair_Homo sapiens_hsa034101.07098892
63Glycerophospholipid metabolism_Homo sapiens_hsa005641.06757568
64Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.06500298
65Pyrimidine metabolism_Homo sapiens_hsa002401.04182474
66Vitamin digestion and absorption_Homo sapiens_hsa049771.04175675
67Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.03922832
68Systemic lupus erythematosus_Homo sapiens_hsa053221.01516569
69Intestinal immune network for IgA production_Homo sapiens_hsa046721.00470936
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.00064277
71Sulfur relay system_Homo sapiens_hsa041220.98772168
72Legionellosis_Homo sapiens_hsa051340.96901477
73Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.96166350
74Primary bile acid biosynthesis_Homo sapiens_hsa001200.93515711
75Herpes simplex infection_Homo sapiens_hsa051680.92680648
76SNARE interactions in vesicular transport_Homo sapiens_hsa041300.91123659
77Steroid hormone biosynthesis_Homo sapiens_hsa001400.90540724
78Proteasome_Homo sapiens_hsa030500.90332144
79Retinol metabolism_Homo sapiens_hsa008300.90194045
80Ether lipid metabolism_Homo sapiens_hsa005650.89361438
81Fructose and mannose metabolism_Homo sapiens_hsa000510.88506406
82Amphetamine addiction_Homo sapiens_hsa050310.87834000
83Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.87570901
84beta-Alanine metabolism_Homo sapiens_hsa004100.84653885
85Renin secretion_Homo sapiens_hsa049240.83655781
86PPAR signaling pathway_Homo sapiens_hsa033200.81691252
87ABC transporters_Homo sapiens_hsa020100.81535033
88Taste transduction_Homo sapiens_hsa047420.81033005
89Fat digestion and absorption_Homo sapiens_hsa049750.79899071
90Circadian rhythm_Homo sapiens_hsa047100.79115436
91Glycosaminoglycan degradation_Homo sapiens_hsa005310.78450226
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.77081715
93Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.75347841
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.73477589
95Carbon metabolism_Homo sapiens_hsa012000.70963917
96Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.68461583
97Measles_Homo sapiens_hsa051620.68015418
98Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.67939905
99Type I diabetes mellitus_Homo sapiens_hsa049400.66639202
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.64808024
101Fatty acid elongation_Homo sapiens_hsa000620.64807406
102Epstein-Barr virus infection_Homo sapiens_hsa051690.63516182
103Pentose and glucuronate interconversions_Homo sapiens_hsa000400.63084880
104Serotonergic synapse_Homo sapiens_hsa047260.61942700
105T cell receptor signaling pathway_Homo sapiens_hsa046600.61842929
106Morphine addiction_Homo sapiens_hsa050320.61683849
107Influenza A_Homo sapiens_hsa051640.61393452
108Ribosome_Homo sapiens_hsa030100.60784848
109Viral carcinogenesis_Homo sapiens_hsa052030.59836684
110Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59422521
111Primary immunodeficiency_Homo sapiens_hsa053400.58479102
112HTLV-I infection_Homo sapiens_hsa051660.57772277
113Cyanoamino acid metabolism_Homo sapiens_hsa004600.57160631
114Arachidonic acid metabolism_Homo sapiens_hsa005900.57133955
115Allograft rejection_Homo sapiens_hsa053300.55028680
116Insulin secretion_Homo sapiens_hsa049110.52682370
117Arginine and proline metabolism_Homo sapiens_hsa003300.51968813
118N-Glycan biosynthesis_Homo sapiens_hsa005100.51655793
119Ovarian steroidogenesis_Homo sapiens_hsa049130.51018848
120Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48148127
121Toxoplasmosis_Homo sapiens_hsa051450.47091430
122Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.46857978
123Mineral absorption_Homo sapiens_hsa049780.46223521
124Collecting duct acid secretion_Homo sapiens_hsa049660.45421677
125p53 signaling pathway_Homo sapiens_hsa041150.44800875
126Central carbon metabolism in cancer_Homo sapiens_hsa052300.44368012
127B cell receptor signaling pathway_Homo sapiens_hsa046620.44332593
128Inositol phosphate metabolism_Homo sapiens_hsa005620.43902843
129Salivary secretion_Homo sapiens_hsa049700.42887968
130Cardiac muscle contraction_Homo sapiens_hsa042600.42310491
131Long-term potentiation_Homo sapiens_hsa047200.41976366
132Steroid biosynthesis_Homo sapiens_hsa001000.41533012
133Circadian entrainment_Homo sapiens_hsa047130.41243450
134GABAergic synapse_Homo sapiens_hsa047270.40809676
135Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.39876098
136cGMP-PKG signaling pathway_Homo sapiens_hsa040220.39659972
137Phosphatidylinositol signaling system_Homo sapiens_hsa040700.39450775
138Sulfur metabolism_Homo sapiens_hsa009200.38985744
139Biosynthesis of amino acids_Homo sapiens_hsa012300.38947069
140VEGF signaling pathway_Homo sapiens_hsa043700.38523461
141Fatty acid metabolism_Homo sapiens_hsa012120.37987358
142Adipocytokine signaling pathway_Homo sapiens_hsa049200.36281135
143Salmonella infection_Homo sapiens_hsa051320.36062441
144Glutathione metabolism_Homo sapiens_hsa004800.34314364
145Alcoholism_Homo sapiens_hsa050340.32470664
146Estrogen signaling pathway_Homo sapiens_hsa049150.30443515
147Hedgehog signaling pathway_Homo sapiens_hsa043400.30041586
148Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.28362352
149Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.27436948
150Asthma_Homo sapiens_hsa053100.23533204
151Thyroid hormone signaling pathway_Homo sapiens_hsa049190.23054561
152Calcium signaling pathway_Homo sapiens_hsa040200.22361504
153Endocytosis_Homo sapiens_hsa041440.22229493
154Wnt signaling pathway_Homo sapiens_hsa043100.20728204
155Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.20568138
156Fatty acid degradation_Homo sapiens_hsa000710.20342718
157AMPK signaling pathway_Homo sapiens_hsa041520.20079682
158RNA polymerase_Homo sapiens_hsa030200.18496784
159Graft-versus-host disease_Homo sapiens_hsa053320.18378464
160Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.17107735
161Metabolic pathways_Homo sapiens_hsa011000.17018426
162Chemical carcinogenesis_Homo sapiens_hsa052040.16623306

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