BNIPL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene interacts with several other proteins, such as BCL2, ARHGAP1, MIF and GFER. It may function as a bridge molecule between BCL2 and ARHGAP1/CDC42 in promoting cell death. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)9.68431934
2keratinocyte differentiation (GO:0030216)7.52394659
3multicellular organismal water homeostasis (GO:0050891)7.36094411
4intermediate filament organization (GO:0045109)6.83798113
5bundle of His cell to Purkinje myocyte communication (GO:0086069)6.82155836
6peptide cross-linking (GO:0018149)6.75442173
7water homeostasis (GO:0030104)6.11752952
8epidermal cell differentiation (GO:0009913)5.92303792
9epidermis development (GO:0008544)5.80199703
10keratinocyte proliferation (GO:0043616)5.33721318
11keratinocyte development (GO:0003334)5.01713587
12interferon-gamma secretion (GO:0072643)4.81154737
13skin morphogenesis (GO:0043589)4.77877803
14ectoderm development (GO:0007398)4.67348914
15sphingoid metabolic process (GO:0046519)4.42998944
16phosphatidylethanolamine acyl-chain remodeling (GO:0036152)4.40718836
17behavioral response to nicotine (GO:0035095)4.39975579
18epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.36958101
19negative regulation of cell fate specification (GO:0009996)4.29504604
20cilium or flagellum-dependent cell motility (GO:0001539)4.22418325
21sphingosine metabolic process (GO:0006670)4.19798802
22axonemal dynein complex assembly (GO:0070286)4.17421448
23intermediate filament cytoskeleton organization (GO:0045104)4.16586652
24long-chain fatty acid biosynthetic process (GO:0042759)4.09805706
25negative regulation of keratinocyte proliferation (GO:0010839)4.06798056
26intermediate filament-based process (GO:0045103)4.03114224
27regulation of chemokine secretion (GO:0090196)3.99419541
28surfactant homeostasis (GO:0043129)3.99345752
29diol metabolic process (GO:0034311)3.89487218
30axoneme assembly (GO:0035082)3.88717619
31epithelial cilium movement (GO:0003351)3.87682595
32fucose catabolic process (GO:0019317)3.81267850
33L-fucose metabolic process (GO:0042354)3.81267850
34L-fucose catabolic process (GO:0042355)3.81267850
35platelet dense granule organization (GO:0060155)3.80209870
36cilium movement (GO:0003341)3.74676843
37hair follicle morphogenesis (GO:0031069)3.71881798
38detection of light stimulus involved in visual perception (GO:0050908)3.67159811
39detection of light stimulus involved in sensory perception (GO:0050962)3.67159811
40regulation of ruffle assembly (GO:1900027)3.65780890
41phosphatidylcholine acyl-chain remodeling (GO:0036151)3.62044377
42chemical homeostasis within a tissue (GO:0048875)3.60986614
43adhesion of symbiont to host cell (GO:0044650)3.60321681
44virion attachment to host cell (GO:0019062)3.60321681
45prostaglandin biosynthetic process (GO:0001516)3.59612824
46prostanoid biosynthetic process (GO:0046457)3.59612824
47regulation of phospholipase A2 activity (GO:0032429)3.50829507
48negative regulation of cell fate commitment (GO:0010454)3.45583114
49viral transcription (GO:0019083)3.45411094
50fatty acid elongation (GO:0030497)3.44555845
51regulation of hippo signaling (GO:0035330)3.43208817
52response to pheromone (GO:0019236)3.37063955
53thyroid hormone generation (GO:0006590)3.30776932
54positive regulation of interleukin-8 secretion (GO:2000484)3.28881197
55cell-substrate junction assembly (GO:0007044)3.27290261
56atrioventricular valve morphogenesis (GO:0003181)3.23872657
57translational termination (GO:0006415)3.23647845
58prostate gland growth (GO:0060736)3.20747637
59adhesion of symbiont to host (GO:0044406)3.20397913
60preassembly of GPI anchor in ER membrane (GO:0016254)3.19733374
61intestinal epithelial cell development (GO:0060576)3.19059622
62DNA deamination (GO:0045006)3.13626817
63cornea development in camera-type eye (GO:0061303)3.12608748
64epithelial cell-cell adhesion (GO:0090136)3.12317906
65planar cell polarity pathway involved in neural tube closure (GO:0090179)3.10849793
66hair cycle process (GO:0022405)3.08538002
67molting cycle process (GO:0022404)3.08538002
68regulation of cardioblast differentiation (GO:0051890)3.06784464
69positive regulation of epidermis development (GO:0045684)3.04623763
70ribosomal small subunit biogenesis (GO:0042274)3.02255805
71regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.01545006
72glucosamine-containing compound catabolic process (GO:1901072)3.01060546
73gland morphogenesis (GO:0022612)2.99675945
74cellular ketone body metabolic process (GO:0046950)2.98216368
75regulation of cell proliferation involved in kidney development (GO:1901722)2.97949940
76GPI anchor metabolic process (GO:0006505)2.97294522
77cardiac right ventricle morphogenesis (GO:0003215)2.97149207
78epithelial cell maturation (GO:0002070)2.92790080
79phosphatidylinositol acyl-chain remodeling (GO:0036149)2.92200649
80lateral sprouting from an epithelium (GO:0060601)2.91855067
81epithelium development (GO:0060429)2.90292518
82indolalkylamine metabolic process (GO:0006586)2.89737673
83establishment of tissue polarity (GO:0007164)2.89693807
84establishment of planar polarity (GO:0001736)2.89693807
85regulation of keratinocyte differentiation (GO:0045616)2.87001380
86transepithelial transport (GO:0070633)2.86736211
87phosphatidylserine acyl-chain remodeling (GO:0036150)2.86542048
88photoreceptor cell maintenance (GO:0045494)2.84292408
89regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.83865143
90respiratory chain complex IV assembly (GO:0008535)2.82145661
91negative regulation of mast cell activation (GO:0033004)2.82071118
92positive regulation of epidermal cell differentiation (GO:0045606)2.82060031
93skin development (GO:0043588)2.80645822
94cilium morphogenesis (GO:0060271)2.79519006
95phospholipid scrambling (GO:0017121)2.78137446
96regulation of epidermis development (GO:0045682)2.76937620
97epithelial cell differentiation involved in prostate gland development (GO:0060742)2.76606872
98magnesium ion transport (GO:0015693)2.76594023
99positive regulation of hair follicle development (GO:0051798)2.75502475
100positive regulation of hair cycle (GO:0042635)2.75502475
101regulation of interleukin-8 secretion (GO:2000482)2.73433435
102ketone body metabolic process (GO:1902224)2.72466461
103eyelid development in camera-type eye (GO:0061029)2.72368369
104prostanoid metabolic process (GO:0006692)2.71783122
105prostaglandin metabolic process (GO:0006693)2.71783122
106tryptophan catabolic process (GO:0006569)2.71339482
107indole-containing compound catabolic process (GO:0042436)2.71339482
108indolalkylamine catabolic process (GO:0046218)2.71339482
109regulation of cell fate specification (GO:0042659)2.71055720
110thyroid hormone metabolic process (GO:0042403)2.68268098
111multicellular organism reproduction (GO:0032504)2.68025225
112water-soluble vitamin biosynthetic process (GO:0042364)2.67217734
113cilium organization (GO:0044782)2.67035805
114regulation of action potential (GO:0098900)2.65472060
115hair follicle development (GO:0001942)2.64763699
116phosphatidylserine metabolic process (GO:0006658)2.64613154
117protein K11-linked deubiquitination (GO:0035871)2.63743133
118GPI anchor biosynthetic process (GO:0006506)2.62338403
119regulation of cilium movement (GO:0003352)2.61699816
120peristalsis (GO:0030432)2.60715464
121polarized epithelial cell differentiation (GO:0030859)2.60304775
122viral life cycle (GO:0019058)2.60100203
123purinergic nucleotide receptor signaling pathway (GO:0035590)2.60067908
124photoreceptor cell development (GO:0042461)2.59889897
125SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.58473980
126phospholipid catabolic process (GO:0009395)2.57717190
127motile cilium assembly (GO:0044458)2.57715187
128cilium assembly (GO:0042384)2.57247569
129cell surface receptor signaling pathway involved in heart development (GO:0061311)2.57072796
130phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.56331212
131protein targeting to ER (GO:0045047)2.55296219
132detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.55265595
133one-carbon compound transport (GO:0019755)2.55179278
134translational elongation (GO:0006414)2.54487004
135sympathetic nervous system development (GO:0048485)2.53703017
136regulation of hair follicle development (GO:0051797)2.52681984
137nonmotile primary cilium assembly (GO:0035058)2.52026607
138regulation of transforming growth factor beta1 production (GO:0032908)2.51973181
139membrane budding (GO:0006900)2.51260780
140pattern specification involved in kidney development (GO:0061004)2.51226117
141lipoxygenase pathway (GO:0019372)2.51050081
142ventricular cardiac muscle cell action potential (GO:0086005)2.50951071
143cotranslational protein targeting to membrane (GO:0006613)2.50126005
144piRNA metabolic process (GO:0034587)2.49835997
145non-canonical Wnt signaling pathway (GO:0035567)2.49614519
146G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.49512921
147parturition (GO:0007567)2.48275641
148establishment of protein localization to endoplasmic reticulum (GO:0072599)2.47403385
149neuronal action potential (GO:0019228)2.47240068
150dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.46919510
151phasic smooth muscle contraction (GO:0014821)2.42365732
152adaptation of signaling pathway (GO:0023058)2.41868540
153kynurenine metabolic process (GO:0070189)2.41062683
154calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.37965825
1553-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.37261001
156purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.37261001
157reflex (GO:0060004)2.37185056
158cellular response to ATP (GO:0071318)2.36618117
159DNA methylation involved in gamete generation (GO:0043046)2.36169251
160tryptophan metabolic process (GO:0006568)2.35928060
161mannosylation (GO:0097502)2.35919495
162desmosome organization (GO:0002934)13.4846629
163keratinization (GO:0031424)12.5703620
164hair cycle (GO:0042633)11.6790020
165molting cycle (GO:0042303)11.6790020
166establishment of skin barrier (GO:0061436)11.3446440
167regulation of water loss via skin (GO:0033561)10.5586431

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.48494209
2VDR_22108803_ChIP-Seq_LS180_Human3.85193322
3ZNF274_21170338_ChIP-Seq_K562_Hela3.49907515
4P63_26484246_Chip-Seq_KERATINOCYTES_Human3.10319154
5SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.05787842
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.03715306
7ESR1_21235772_ChIP-Seq_MCF-7_Human2.95710448
8ZNF263_19887448_ChIP-Seq_K562_Human2.95502037
9SOX9_24532713_ChIP-Seq_HFSC_Mouse2.72480718
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.50246680
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.49646578
12ESR2_21235772_ChIP-Seq_MCF-7_Human2.38387363
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.23129247
14SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.09314146
15SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.09314146
16TRIM28_21343339_ChIP-Seq_HEK293_Human2.09267176
17STAT6_21828071_ChIP-Seq_BEAS2B_Human2.07805942
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.05729218
19CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.00452890
20TP63_17297297_ChIP-ChIP_HaCaT_Human14.8771321
21IGF1R_20145208_ChIP-Seq_DFB_Human1.99071333
22TAF15_26573619_Chip-Seq_HEK293_Human1.98844948
23CTBP2_25329375_ChIP-Seq_LNCAP_Human1.97402509
24FOXO3_23340844_ChIP-Seq_DLD1_Human1.95812747
25ER_23166858_ChIP-Seq_MCF-7_Human1.92647035
26FUS_26573619_Chip-Seq_HEK293_Human1.78578694
27POU3F2_20337985_ChIP-ChIP_501MEL_Human1.78090092
28GBX2_23144817_ChIP-Seq_PC3_Human1.76601315
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.74387008
30RARG_19884340_ChIP-ChIP_MEFs_Mouse1.73443994
31HIF1A_21447827_ChIP-Seq_MCF-7_Human1.73246825
32EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.70658648
33KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.64173660
34EWS_26573619_Chip-Seq_HEK293_Human1.62553601
35SOX2_20726797_ChIP-Seq_SW620_Human1.61412777
36HOXB7_26014856_ChIP-Seq_BT474_Human1.61220847
37ZNF217_24962896_ChIP-Seq_MCF-7_Human1.60711553
38RACK7_27058665_Chip-Seq_MCF-7_Human1.58361802
39FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.56974638
40PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.52926984
41* FOXA1_25329375_ChIP-Seq_VCAP_Human1.52909627
42* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.52909627
43PIAS1_25552417_ChIP-Seq_VCAP_Human1.50619869
44TCF4_22108803_ChIP-Seq_LS180_Human1.50259432
45GATA3_21878914_ChIP-Seq_MCF-7_Human1.48567387
46RUNX1_27514584_Chip-Seq_MCF-7_Human1.46367484
47STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.44737655
48AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.44438394
49P300_19829295_ChIP-Seq_ESCs_Human1.44359248
50KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.44316364
51NCOR_22424771_ChIP-Seq_293T_Human1.40607102
52HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.39914204
53ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.38642159
54GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.37562155
55IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37392241
56CBP_20019798_ChIP-Seq_JUKART_Human1.37392241
57KLF5_25053715_ChIP-Seq_YYC3_Human1.36913868
58EGR1_23403033_ChIP-Seq_LIVER_Mouse1.36733432
59AR_25329375_ChIP-Seq_VCAP_Human1.36192946
60GATA3_24758297_ChIP-Seq_MCF-7_Human1.36087010
61BMI1_23680149_ChIP-Seq_NPCS_Mouse1.34686000
62TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.33496458
63EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.31702705
64NOTCH1_21737748_ChIP-Seq_TLL_Human1.31090287
65GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30105271
66FLI1_27457419_Chip-Seq_LIVER_Mouse1.29933159
67CJUN_26792858_Chip-Seq_BT549_Human1.29675451
68TP63_23658742_ChIP-Seq_EP156T_Human1.28543334
69CLOCK_20551151_ChIP-Seq_293T_Human1.28108411
70AR_20517297_ChIP-Seq_VCAP_Human1.27814046
71SALL1_21062744_ChIP-ChIP_HESCs_Human1.27259923
72AHR_22903824_ChIP-Seq_MCF-7_Human1.27137456
73TP53_22573176_ChIP-Seq_HFKS_Human1.25026992
74ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.24678398
75ATF3_27146783_Chip-Seq_COLON_Human1.24504672
76UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24283525
77TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23540184
78POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.23540184
79UBF1/2_26484160_Chip-Seq_HMECs_Human1.22625453
80* TP63_22573176_ChIP-Seq_HFKS_Human1.21683246
81ERA_21632823_ChIP-Seq_H3396_Human1.21220944
82RXR_22108803_ChIP-Seq_LS180_Human1.21195684
83GATA4_25053715_ChIP-Seq_YYC3_Human1.20320763
84NANOG_20526341_ChIP-Seq_ESCs_Human1.20280556
85STAT3_23295773_ChIP-Seq_U87_Human1.19128935
86NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18995711
87KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18679721
88FOXA1_21572438_ChIP-Seq_LNCaP_Human1.18552359
89SOX2_27498859_Chip-Seq_STOMACH_Mouse1.18022657
90GATA6_25053715_ChIP-Seq_YYC3_Human1.17937683
91P53_21459846_ChIP-Seq_SAOS-2_Human1.17860441
92NANOG_19829295_ChIP-Seq_ESCs_Human1.17154640
93SOX2_19829295_ChIP-Seq_ESCs_Human1.17154640
94TAF2_19829295_ChIP-Seq_ESCs_Human1.17091201
95SMAD4_21799915_ChIP-Seq_A2780_Human1.15071390
96SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12368969
97CDX2_20551321_ChIP-Seq_CACO-2_Human1.12236683
98SMAD3_21741376_ChIP-Seq_EPCs_Human1.12155428
99CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.12074234
100UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.11649796
101TCF4_23295773_ChIP-Seq_U87_Human1.11646168
102NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.11565889
103RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08652564
104* BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.08285871
105FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.07468224
106FOXH1_21741376_ChIP-Seq_EPCs_Human1.06248771
107* ERG_20517297_ChIP-Seq_VCAP_Human1.05693679
108OCT4_20526341_ChIP-Seq_ESCs_Human1.05600361
109GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.05537925
110AR_21572438_ChIP-Seq_LNCaP_Human1.05377709
111TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05374974
112PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.05335416
113AUTS2_25519132_ChIP-Seq_293T-REX_Human1.04652468
114* MYC_19829295_ChIP-Seq_ESCs_Human1.04453744
115SMAD4_21741376_ChIP-Seq_EPCs_Human1.04267599
116TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04196300
117SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.04058835
118TCF4_18268006_ChIP-ChIP_LS174T_Human1.03951388
119FOXH1_21741376_ChIP-Seq_ESCs_Human1.03780393
120TDRD3_21172665_ChIP-Seq_MCF-7_Human1.03558499
121MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03499269
122* PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.03356105
123ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.03273470
124TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.02978063
125PPAR_26484153_Chip-Seq_NCI-H1993_Human1.02800329
126ETV2_25802403_ChIP-Seq_MESCs_Mouse1.02509644
127TP53_18474530_ChIP-ChIP_U2OS_Human1.01983516
128RUNX2_22187159_ChIP-Seq_PCA_Human1.01281684
129RBPJ_21746931_ChIP-Seq_IB4_Human1.01261329
130REST_21632747_ChIP-Seq_MESCs_Mouse0.99867791
131TP53_20018659_ChIP-ChIP_R1E_Mouse0.98577126
132TBL1_22424771_ChIP-Seq_293T_Human0.98047130
133MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.96886386
134CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.96240613
135ESR1_20079471_ChIP-ChIP_T-47D_Human0.95711880
136SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.95690901
137* GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.91793869
138JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90933082
139FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.88253162
140ARNT_22903824_ChIP-Seq_MCF-7_Human0.88249516
141CTCF_27219007_Chip-Seq_Bcells_Human0.87345530
142* P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.87315433
143SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.85141180
144JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85037145
145LXR_22292898_ChIP-Seq_THP-1_Human0.84824499
146RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.84621561
147SA1_27219007_Chip-Seq_ERYTHROID_Human0.83685095
148CTCF_20526341_ChIP-Seq_ESCs_Human0.83177207
149P300_27058665_Chip-Seq_ZR-75-30cells_Human0.81823878
150CEBPB_22108803_ChIP-Seq_LS180_Human0.79482228
151GATA6_21074721_ChIP-Seq_CACO-2_Human0.78166456
152ELK3_25401928_ChIP-Seq_HUVEC_Human0.76680426
153DNAJC2_21179169_ChIP-ChIP_NT2_Human0.75690600
154RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.75037111
155ERG_21242973_ChIP-ChIP_JURKAT_Human0.73407591
156KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.72879214
157KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.72879214
158KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.72879214
159EGR1_19032775_ChIP-ChIP_M12_Human0.71576755
160GATA2_21666600_ChIP-Seq_HMVEC_Human0.71010784
161TCF3_18692474_ChIP-Seq_MEFs_Mouse0.70090813
162FOXM1_26456572_ChIP-Seq_MCF-7_Human0.69692685
163KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.69229090
164CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.68782102
165ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.68172163
166KDM2B_26808549_Chip-Seq_K562_Human0.67708897
167ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.66826460
168BCOR_27268052_Chip-Seq_Bcells_Human0.66382002
169YY1_22570637_ChIP-Seq_MALME-3M_Human0.65747770
170AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.65120507
171NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.64897288
172VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.62459468
173FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.62154842
174TP53_16413492_ChIP-PET_HCT116_Human0.61929030
175* CSB_26484114_Chip-Seq_FIBROBLAST_Human0.61414368
176NANOG_18692474_ChIP-Seq_MEFs_Mouse0.60825024
177SUZ12_27294783_Chip-Seq_ESCs_Mouse0.60401224
178P68_20966046_ChIP-Seq_HELA_Human0.59853562
179PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.59838745
180BCAT_22108803_ChIP-Seq_LS180_Human0.58157215

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier7.05235200
2MP0010234_abnormal_vibrissa_follicle5.54193537
3MP0005275_abnormal_skin_tensile5.22824430
4MP0000579_abnormal_nail_morphology4.61373142
5MP0005501_abnormal_skin_physiology4.41062408
6MP0000383_abnormal_hair_follicle3.75346976
7MP0003941_abnormal_skin_development3.74401646
8MP0002254_reproductive_system_inflammat3.70087691
9MP0010678_abnormal_skin_adnexa3.61457219
10MP0002098_abnormal_vibrissa_morphology3.58633314
11MP0002060_abnormal_skin_morphology3.28532872
12MP0001216_abnormal_epidermal_layer3.25808281
13MP0004381_abnormal_hair_follicle3.22489035
14MP0000647_abnormal_sebaceous_gland3.08947896
15MP0003453_abnormal_keratinocyte_physiol3.07101198
16MP0003705_abnormal_hypodermis_morpholog2.85854222
17MP0010771_integument_phenotype2.79570209
18MP0000377_abnormal_hair_follicle2.77823461
19MP0001188_hyperpigmentation2.50707653
20MP0000467_abnormal_esophagus_morphology2.48574239
21MP0000566_synostosis2.34740813
22MP0000762_abnormal_tongue_morphology2.33029999
23MP0004043_abnormal_pH_regulation2.32011899
24MP0004947_skin_inflammation2.30375022
25MP0005174_abnormal_tail_pigmentation2.21086672
26MP0000427_abnormal_hair_cycle2.19222672
27MP0005075_abnormal_melanosome_morpholog1.99337390
28MP0003878_abnormal_ear_physiology1.98829880
29MP0005377_hearing/vestibular/ear_phenot1.98829880
30MP0003566_abnormal_cell_adhesion1.94407109
31MP0008875_abnormal_xenobiotic_pharmacok1.78570121
32MP0005551_abnormal_eye_electrophysiolog1.77656127
33MP0000015_abnormal_ear_pigmentation1.73833992
34MP0005083_abnormal_biliary_tract1.66710374
35MP0001346_abnormal_lacrimal_gland1.66096731
36MP0003195_calcinosis1.63383431
37MP0001919_abnormal_reproductive_system1.60930816
38MP0009931_abnormal_skin_appearance1.59532336
39MP0002234_abnormal_pharynx_morphology1.58642065
40MP0001243_abnormal_dermal_layer1.55135604
41MP0001968_abnormal_touch/_nociception1.46492614
42MP0001191_abnormal_skin_condition1.46274241
43MP0006072_abnormal_retinal_apoptosis1.45935384
44MP0002653_abnormal_ependyma_morphology1.42614677
45MP0000367_abnormal_coat/_hair1.42185428
46MP0009053_abnormal_anal_canal1.40580329
47MP0008872_abnormal_physiological_respon1.40108506
48MP0003136_yellow_coat_color1.39775343
49MP0004185_abnormal_adipocyte_glucose1.37887322
50MP0000537_abnormal_urethra_morphology1.37081481
51MP0005389_reproductive_system_phenotype1.34648242
52MP0002009_preneoplasia1.32568983
53MP0001849_ear_inflammation1.25075735
54MP0002876_abnormal_thyroid_physiology1.23768321
55MP0004782_abnormal_surfactant_physiolog1.22888794
56MP0001873_stomach_inflammation1.22079448
57MP0010030_abnormal_orbit_morphology1.20799809
58MP0009780_abnormal_chondrocyte_physiolo1.20776114
59MP0008995_early_reproductive_senescence1.19342153
60MP0008877_abnormal_DNA_methylation1.16965839
61MP0010352_gastrointestinal_tract_polyps1.16194784
62MP0005253_abnormal_eye_physiology1.15831311
63MP0002277_abnormal_respiratory_mucosa1.14936917
64MP0002736_abnormal_nociception_after1.11762567
65MP0001986_abnormal_taste_sensitivity1.10212544
66MP0002160_abnormal_reproductive_system1.05120063
67MP0004133_heterotaxia1.04774393
68MP0001765_abnormal_ion_homeostasis1.04607348
69MP0001851_eye_inflammation1.01666061
70MP0005023_abnormal_wound_healing0.98567079
71MP0001485_abnormal_pinna_reflex0.97700781
72MP0000569_abnormal_digit_pigmentation0.97686298
73MP0000627_abnormal_mammary_gland0.97243787
74MP0005645_abnormal_hypothalamus_physiol0.95537118
75MP0009379_abnormal_foot_pigmentation0.95277913
76MP0002282_abnormal_trachea_morphology0.95146668
77MP0005408_hypopigmentation0.94880768
78MP0009046_muscle_twitch0.94688926
79MP0004264_abnormal_extraembryonic_tissu0.94271459
80MP0003646_muscle_fatigue0.91280478
81MP0002837_dystrophic_cardiac_calcinosis0.90819010
82MP0005646_abnormal_pituitary_gland0.90303347
83MP0001984_abnormal_olfaction0.90117957
84MP0000372_irregular_coat_pigmentation0.88718756
85MP0005451_abnormal_body_composition0.88315840
86MP0008004_abnormal_stomach_pH0.87240463
87MP0005171_absent_coat_pigmentation0.87197646
88MP0001340_abnormal_eyelid_morphology0.87076390
89MP0002909_abnormal_adrenal_gland0.86233052
90MP0002638_abnormal_pupillary_reflex0.82852604
91MP0004142_abnormal_muscle_tone0.80890705
92MP0000465_gastrointestinal_hemorrhage0.79896149
93MP0005076_abnormal_cell_differentiation0.77116602
94MP0005379_endocrine/exocrine_gland_phen0.76993410
95MP0002006_tumorigenesis0.74240503
96MP0005409_darkened_coat_color0.73848321
97MP0000631_abnormal_neuroendocrine_gland0.73695649
98MP0008789_abnormal_olfactory_epithelium0.73505471
99MP0005636_abnormal_mineral_homeostasis0.72892516
100MP0003315_abnormal_perineum_morphology0.70354308
101MP0004147_increased_porphyrin_level0.70076217
102MP0003191_abnormal_cellular_cholesterol0.69082663
103MP0006276_abnormal_autonomic_nervous0.67572287
104MP0003755_abnormal_palate_morphology0.67137653
105MP0002102_abnormal_ear_morphology0.66137365
106MP0009745_abnormal_behavioral_response0.65720675
107MP0005367_renal/urinary_system_phenotyp0.65648321
108MP0000516_abnormal_urinary_system0.65648321
109MP0004742_abnormal_vestibular_system0.65646052
110MP0001756_abnormal_urination0.65471975
111MP0002166_altered_tumor_susceptibility0.64361603
112MP0001502_abnormal_circadian_rhythm0.64323018
113MP0000678_abnormal_parathyroid_gland0.64045889
114MP0009384_cardiac_valve_regurgitation0.62852308
115MP0002557_abnormal_social/conspecific_i0.62734536
116MP0001324_abnormal_eye_pigmentation0.61014464
117MP0002249_abnormal_larynx_morphology0.60803694
118MP0003950_abnormal_plasma_membrane0.60795388
119MP0002877_abnormal_melanocyte_morpholog0.60033000
120MP0002233_abnormal_nose_morphology0.58771647
121MP0002735_abnormal_chemical_nociception0.58752888
122MP0003880_abnormal_central_pattern0.57944345
123MP0003011_delayed_dark_adaptation0.57809069
124MP0005394_taste/olfaction_phenotype0.57041232
125MP0005499_abnormal_olfactory_system0.57041232
126MP0004272_abnormal_basement_membrane0.56860877
127MP0005423_abnormal_somatic_nervous0.56081437
128MP0001784_abnormal_fluid_regulation0.55998214
129MP0000470_abnormal_stomach_morphology0.55780533
130MP0002111_abnormal_tail_morphology0.54347514
131MP0005248_abnormal_Harderian_gland0.51417881
132MP0002177_abnormal_outer_ear0.50590932
133MP0004019_abnormal_vitamin_homeostasis0.50430676
134MP0009250_abnormal_appendicular_skeleto0.47331628
135MP0002896_abnormal_bone_mineralization0.46373770
136MP0005508_abnormal_skeleton_morphology0.46234565
137MP0001881_abnormal_mammary_gland0.46123394
138MP0003436_decreased_susceptibility_to0.42655290
139MP0000613_abnormal_salivary_gland0.42400145
140MP0000462_abnormal_digestive_system0.41889166
141MP0000432_abnormal_head_morphology0.41402396
142MP0002095_abnormal_skin_pigmentation0.39722536
143MP0000538_abnormal_urinary_bladder0.39272472
144MP0003448_altered_tumor_morphology0.38601402
145MP0002132_abnormal_respiratory_system0.38263353
146MP0005666_abnormal_adipose_tissue0.36716913
147MP0003936_abnormal_reproductive_system0.35981883
148MP0005187_abnormal_penis_morphology0.33014329
149MP0000681_abnormal_thyroid_gland0.31992802
150MP0008438_abnormal_cutaneous_collagen0.31891247
151MP0003638_abnormal_response/metabolism_0.31632337
152MP0004885_abnormal_endolymph0.31008459
153MP0001177_atelectasis0.30999159
154MP0003763_abnormal_thymus_physiology0.27512222
155MP0005390_skeleton_phenotype0.27477259
156MP0002109_abnormal_limb_morphology0.26969721
157MP0003937_abnormal_limbs/digits/tail_de0.26720989
158MP0000163_abnormal_cartilage_morphology0.26645609
159MP0006054_spinal_hemorrhage0.26419493

Predicted human phenotypes

RankGene SetZ-score
1Hypotrichosis (HP:0001006)7.83408855
2Plantar hyperkeratosis (HP:0007556)6.76773649
3Woolly hair (HP:0002224)6.65567987
4Pili torti (HP:0003777)6.62769700
5Onycholysis (HP:0001806)6.50595258
6Palmoplantar hyperkeratosis (HP:0000972)6.22549543
7Abnormality of nail color (HP:0100643)6.19088272
8Right ventricular cardiomyopathy (HP:0011663)6.15751426
9Fragile nails (HP:0001808)6.11503649
10Palmar hyperkeratosis (HP:0010765)5.91228796
11Milia (HP:0001056)5.85714384
12Increased IgE level (HP:0003212)5.47365621
13Thick nail (HP:0001805)5.04919745
14Congenital ichthyosiform erythroderma (HP:0007431)4.77069831
15Nail dystrophy (HP:0008404)4.75007975
16Alopecia of scalp (HP:0002293)4.25267312
17Lip pit (HP:0100267)4.21256089
18Erythema (HP:0010783)4.08988255
19Abnormal hair laboratory examination (HP:0003328)4.06239968
20Abnormal blistering of the skin (HP:0008066)4.03778038
21Parakeratosis (HP:0001036)4.02677740
22Erythroderma (HP:0001019)3.98846353
23Pancreatic cysts (HP:0001737)3.98544146
24Conjunctival hamartoma (HP:0100780)3.87054460
25True hermaphroditism (HP:0010459)3.76260020
26Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.69843654
27Pancreatic fibrosis (HP:0100732)3.64333042
28Atrophic scars (HP:0001075)3.54116899
29Furrowed tongue (HP:0000221)3.39902202
30Natal tooth (HP:0000695)3.34053570
31Molar tooth sign on MRI (HP:0002419)3.26643864
32Abnormality of midbrain morphology (HP:0002418)3.26643864
33Abnormal respiratory motile cilium morphology (HP:0005938)3.25789090
34Abnormal respiratory epithelium morphology (HP:0012253)3.25789090
35Congenital stationary night blindness (HP:0007642)3.22908113
36Advanced eruption of teeth (HP:0006288)3.20026242
37Dynein arm defect of respiratory motile cilia (HP:0012255)3.19655643
38Absent/shortened dynein arms (HP:0200106)3.19655643
39Sparse eyelashes (HP:0000653)3.16693096
40Corneal erosion (HP:0200020)3.08462195
41Curly hair (HP:0002212)3.07549630
42Ectropion (HP:0000656)3.01298774
43Hypohidrosis (HP:0000966)2.92930502
44Ridged nail (HP:0001807)2.89051195
45Duplicated collecting system (HP:0000081)2.87686569
46Nephronophthisis (HP:0000090)2.81510299
47Palmoplantar keratoderma (HP:0000982)2.80663634
48Abnormal ciliary motility (HP:0012262)2.76839053
49Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.76626287
50Gangrene (HP:0100758)2.73438262
51Abnormality of the renal collecting system (HP:0004742)2.71120124
52Ventricular tachycardia (HP:0004756)2.70515724
53Follicular hyperkeratosis (HP:0007502)2.66748445
54Brittle hair (HP:0002299)2.63795824
55Abnormal respiratory motile cilium physiology (HP:0012261)2.62903507
56Cystic liver disease (HP:0006706)2.62632244
57Distal lower limb muscle weakness (HP:0009053)2.61835378
58Hyporeflexia of lower limbs (HP:0002600)2.61742580
59Abnormality of the renal cortex (HP:0011035)2.60472635
60Attenuation of retinal blood vessels (HP:0007843)2.58558568
61Abnormality of the renal medulla (HP:0100957)2.56929238
62Pruritus (HP:0000989)2.53262530
63Acanthosis nigricans (HP:0000956)2.49087724
64Pendular nystagmus (HP:0012043)2.44558811
65Aplasia cutis congenita (HP:0001057)2.42599551
66Tubular atrophy (HP:0000092)2.42144813
67Aplasia involving bones of the upper limbs (HP:0009823)2.38019247
68Aplasia of the phalanges of the hand (HP:0009802)2.38019247
69Aplasia involving bones of the extremities (HP:0009825)2.38019247
70Stomach cancer (HP:0012126)2.37849886
71Rhinitis (HP:0012384)2.31329286
72Abnormal rod and cone electroretinograms (HP:0008323)2.30863744
73Sparse scalp hair (HP:0002209)2.30669747
74Oral leukoplakia (HP:0002745)2.29848972
75Popliteal pterygium (HP:0009756)2.25131149
76Hamartoma of the eye (HP:0010568)2.24678970
77Hypoplastic labia majora (HP:0000059)2.23633037
78Blepharitis (HP:0000498)2.21558386
79Chronic hepatic failure (HP:0100626)2.20387701
80Congenital, generalized hypertrichosis (HP:0004540)2.19911921
81Slow-growing hair (HP:0002217)2.19057372
82Abnormality of hair growth rate (HP:0011363)2.19057372
83Fatigable weakness (HP:0003473)2.14133410
84Abnormality of the neuromuscular junction (HP:0003398)2.14133410
85Abnormality of alanine metabolism (HP:0010916)2.13869662
86Hyperalaninemia (HP:0003348)2.13869662
87Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.13869662
88Increased connective tissue (HP:0009025)2.13361333
89Chronic bronchitis (HP:0004469)2.10781928
90Aplasia/Hypoplasia of the tongue (HP:0010295)2.09923868
91Decreased central vision (HP:0007663)2.09609727
92Bile duct proliferation (HP:0001408)2.09578351
93Abnormal biliary tract physiology (HP:0012439)2.09578351
94Anonychia (HP:0001798)2.08773563
95Absent rod-and cone-mediated responses on ERG (HP:0007688)2.07278651
96Decreased circulating renin level (HP:0003351)2.07246260
97Concave nail (HP:0001598)2.07005716
98Hypoplasia of dental enamel (HP:0006297)2.06663138
99Abnormality of the axillary hair (HP:0100134)2.06143806
100Abnormality of secondary sexual hair (HP:0009888)2.06143806
101Abnormality of the salivary glands (HP:0010286)2.05748509
102Abolished electroretinogram (ERG) (HP:0000550)2.05060324
103Anencephaly (HP:0002323)2.04939603
104Type II lissencephaly (HP:0007260)2.04847417
105Fragile skin (HP:0001030)2.03586533
106Stenosis of the external auditory canal (HP:0000402)2.02835810
107Hypergammaglobulinemia (HP:0010702)2.02435320
108Medial flaring of the eyebrow (HP:0010747)2.01195342
109Abnormality of the labia majora (HP:0012881)1.98941972
110Male pseudohermaphroditism (HP:0000037)1.97262944
111Abnormal drinking behavior (HP:0030082)1.94028292
112Polydipsia (HP:0001959)1.94028292
113Congenital hepatic fibrosis (HP:0002612)1.92861975
114Conical tooth (HP:0000698)1.91761885
115Abnormality of the gastric mucosa (HP:0004295)1.87091620
116Type 1 muscle fiber predominance (HP:0003803)1.86806473
117Bronchiectasis (HP:0002110)1.86290897
118Abnormality of the distal phalanges of the toes (HP:0010182)1.84170582
119Sclerocornea (HP:0000647)1.83265966
120Pterygium (HP:0001059)1.82939789
121Flat capital femoral epiphysis (HP:0003370)1.74245834
122Bronchomalacia (HP:0002780)1.74171060
123Round ear (HP:0100830)1.73968575
124Decreased electroretinogram (ERG) amplitude (HP:0000654)1.72927582
125Hyperhidrosis (HP:0000975)1.72715008
126Ulnar deviation of the wrist (HP:0003049)1.72058537
127Skin ulcer (HP:0200042)1.71675140
128Hyperventilation (HP:0002883)1.70614865
129Down-sloping shoulders (HP:0200021)1.70333441
130Abnormal hemoglobin (HP:0011902)1.69840543
131Postaxial foot polydactyly (HP:0001830)1.69766599
132Oligodontia (HP:0000677)1.69681557
133Distal arthrogryposis (HP:0005684)1.68630184
134Absent hair (HP:0002298)1.67162183
135Laryngomalacia (HP:0001601)1.67136533
136Skin pits (HP:0100276)1.64828716
137Trismus (HP:0000211)1.63150608
138Inability to walk (HP:0002540)1.62201581
139Aplasia/Hypoplasia of the spleen (HP:0010451)1.62036525
140Fair hair (HP:0002286)1.60969712
141Dehydration (HP:0001944)1.60961335
142Abnormality of the 2nd finger (HP:0004100)1.60667016
143Large for gestational age (HP:0001520)1.60240814
144Ventricular fibrillation (HP:0001663)1.59960078
145Asplenia (HP:0001746)1.59916964
146Amelogenesis imperfecta (HP:0000705)1.58090542
147Esophageal atresia (HP:0002032)1.56552726
148Abnormality of the fingernails (HP:0001231)1.55388048
149Interstitial pulmonary disease (HP:0006530)1.54296709
150Myopathic facies (HP:0002058)1.52755563
151Lack of skin elasticity (HP:0100679)1.52476302
152Abnormality of the phalanges of the 2nd finger (HP:0009541)1.49805193
153Areflexia of lower limbs (HP:0002522)1.46357975
154Neonatal death (HP:0003811)1.43351739
155Bifid scrotum (HP:0000048)1.43327385
156Hypodontia (HP:0000668)1.40326753
157Nasolacrimal duct obstruction (HP:0000579)1.39774569

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K33.91655032
2EPHA23.83103255
3MST1R3.70400462
4MST43.64150543
5FER3.62867885
6MAPKAPK33.37527204
7ADRBK23.22671661
8BMPR1B3.05631419
9MAP3K22.95240097
10EPHB22.93597779
11GRK12.85970777
12TLK12.77604905
13INSRR2.62835855
14RPS6KB22.50814841
15LATS12.48802190
16MAP4K22.36086147
17WNK32.28273722
18TGFBR12.08995770
19WNK42.07356144
20RPS6KA42.06035144
21ACVR1B1.99428994
22BRSK21.89279730
23NUAK11.83719476
24ERN11.82909441
25MET1.77785879
26TTN1.76471193
27FGFR21.74456635
28TRPM71.73010520
29LRRK21.70059906
30TAOK11.67957078
31FRK1.65704105
32PBK1.65047666
33MAP2K31.61899553
34PTK61.60233613
35MAP2K61.57356814
36SIK11.56761988
37BCR1.55978905
38EPHA31.55751068
39EPHB11.55199598
40CASK1.53877074
41RIPK11.52706703
42TAOK31.51932269
43STK101.49781704
44MAPK131.49359939
45PIK3CG1.45626990
46ERBB31.43186022
47PINK11.40410082
48MUSK1.33539251
49EEF2K1.31433729
50GRK61.28817456
51MAP3K141.23896084
52FGFR11.23197784
53TRIM281.23145995
54ADRBK11.22450074
55MAP2K21.21877507
56PRKCE1.10025511
57PDK21.09901641
58TRIB31.08114102
59TXK1.08108907
60NME11.07975579
61STK241.07353161
62STK38L1.05096547
63FGFR41.04132519
64MAP3K40.97103112
65DYRK20.96100425
66TGFBR20.94956175
67CDK60.94371680
68STK160.94107089
69OXSR10.91408698
70DAPK20.91247997
71LATS20.89640762
72WEE10.88161218
73PRKCI0.87865875
74TESK10.87593033
75MAP2K10.86255679
76CAMKK20.83026679
77DDR20.82474519
78MATK0.80929967
79MAPKAPK20.79405948
80MAPK150.78913016
81MAP3K110.77563457
82IRAK10.76496077
83PTK20.75717968
84MAPKAPK50.72864499
85ERBB20.72729921
86EIF2AK10.71741658
87EIF2AK30.69565712
88PRKCG0.67505554
89PRKAA20.67432892
90MAP3K10.66298901
91ERBB40.66060526
92NME20.63669190
93DYRK1B0.62592354
94STK390.62155271
95BCKDK0.62129679
96VRK10.62002273
97MAP3K70.61416685
98FGFR30.61209495
99WNK10.61128395
100PKN10.60560544
101OBSCN0.59995121
102IKBKE0.58615021
103TSSK60.58516933
104PRKCQ0.57722337
105MAP3K60.55284253
106STK30.55195482
107PRKD10.54844371
108MKNK20.52951948
109LIMK10.52258117
110PIM20.51021434
111CHUK0.50555319
112BMX0.50345352
113CSNK1G10.49599019
114MAP3K120.49282926
115TBK10.48938396
116CSNK1G30.45969604
117FGR0.45866983
118CDK30.45691997
119TESK20.45389144
120TYK20.45244682
121CSNK1G20.44112913
122CSNK1A10.42991840
123IKBKB0.41972664
124PLK20.41939037
125PHKG20.41737541
126PHKG10.41737541
127PTK2B0.39593985
128CSNK1D0.38607024
129MAPK120.38227605
130PAK30.38167113
131ILK0.37982691
132JAK20.37297646
133PIK3CA0.36877440
134MAP3K90.36852654
135IGF1R0.36542886
136PRKACA0.35461713
137BLK0.35121196
138NLK0.34944948
139PRKCA0.34144693
140RPS6KA10.33729767
141MAP2K40.32085111
142RET0.31458306
143PKN20.30846781
144PNCK0.30137218
145PLK40.29955375
146CSNK1A1L0.29886069
147DMPK0.29853229
148STK380.29250690
149PRKAA10.28488182
150TEC0.28155375
151AURKB0.27754814
152SGK10.26580461
153MAPK70.26006853
154CAMK2A0.25910611
155AKT30.25847649
156GSK3A0.25680218
157RPS6KA60.25516954
158CSNK1E0.24997591
159KSR20.24342807
160TYRO30.23601719
161NTRK30.23375567
162PAK40.22984233
163TAOK20.21945413
164MAP3K80.21615703
165ZAK0.21006533
166AKT20.20949239
167RPS6KA50.19716697

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047442.98465674
2Linoleic acid metabolism_Homo sapiens_hsa005912.86033744
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.81965145
4Ribosome_Homo sapiens_hsa030102.72483854
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.67612371
6Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.49380033
7Basal cell carcinoma_Homo sapiens_hsa052172.47423568
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.44737060
9Nitrogen metabolism_Homo sapiens_hsa009102.43006873
10Chemical carcinogenesis_Homo sapiens_hsa052042.25379788
11ECM-receptor interaction_Homo sapiens_hsa045122.23751407
12Sphingolipid metabolism_Homo sapiens_hsa006002.14815849
13Cyanoamino acid metabolism_Homo sapiens_hsa004602.14414570
14Arachidonic acid metabolism_Homo sapiens_hsa005902.12309381
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.11740439
16Adherens junction_Homo sapiens_hsa045201.95533940
17Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.87188644
18Hippo signaling pathway_Homo sapiens_hsa043901.86876403
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.76387411
20Bladder cancer_Homo sapiens_hsa052191.75864323
21Tight junction_Homo sapiens_hsa045301.73405615
22Fatty acid elongation_Homo sapiens_hsa000621.72251619
23Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.70913793
24Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.68374288
25Oxidative phosphorylation_Homo sapiens_hsa001901.66287934
26Butanoate metabolism_Homo sapiens_hsa006501.55879950
27Taste transduction_Homo sapiens_hsa047421.51695763
28Proteoglycans in cancer_Homo sapiens_hsa052051.51394520
29Phenylalanine metabolism_Homo sapiens_hsa003601.50664364
30Ether lipid metabolism_Homo sapiens_hsa005651.47525147
31Nicotine addiction_Homo sapiens_hsa050331.47488917
32Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.43328737
33Amoebiasis_Homo sapiens_hsa051461.42650611
34Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.39847721
35VEGF signaling pathway_Homo sapiens_hsa043701.37142796
36Histidine metabolism_Homo sapiens_hsa003401.34016443
37Ovarian steroidogenesis_Homo sapiens_hsa049131.33857957
38Hedgehog signaling pathway_Homo sapiens_hsa043401.33512655
39Retinol metabolism_Homo sapiens_hsa008301.32730488
40Fatty acid biosynthesis_Homo sapiens_hsa000611.30577836
41Tryptophan metabolism_Homo sapiens_hsa003801.30242908
42Circadian rhythm_Homo sapiens_hsa047101.28870086
43Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.21026567
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.20702383
45Selenocompound metabolism_Homo sapiens_hsa004501.20623738
46Leukocyte transendothelial migration_Homo sapiens_hsa046701.19082664
47Mineral absorption_Homo sapiens_hsa049781.18777381
48Peroxisome_Homo sapiens_hsa041461.18746244
49Basal transcription factors_Homo sapiens_hsa030221.17480431
50Glycerophospholipid metabolism_Homo sapiens_hsa005641.17136962
51Pertussis_Homo sapiens_hsa051331.16898609
52Serotonergic synapse_Homo sapiens_hsa047261.16271291
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.16095869
54Toxoplasmosis_Homo sapiens_hsa051451.15246337
55Pentose and glucuronate interconversions_Homo sapiens_hsa000401.14919853
56beta-Alanine metabolism_Homo sapiens_hsa004101.14510711
57Caffeine metabolism_Homo sapiens_hsa002321.13224052
58Maturity onset diabetes of the young_Homo sapiens_hsa049501.13145146
59Melanogenesis_Homo sapiens_hsa049161.12314112
60Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.09483376
61Intestinal immune network for IgA production_Homo sapiens_hsa046721.08464619
62RNA polymerase_Homo sapiens_hsa030201.08292380
63Small cell lung cancer_Homo sapiens_hsa052221.07422030
64Olfactory transduction_Homo sapiens_hsa047401.07119895
65TGF-beta signaling pathway_Homo sapiens_hsa043501.03951940
66Glutathione metabolism_Homo sapiens_hsa004801.03863688
67Thyroid cancer_Homo sapiens_hsa052161.03248937
68Regulation of autophagy_Homo sapiens_hsa041401.03018627
69Acute myeloid leukemia_Homo sapiens_hsa052211.02297664
70Homologous recombination_Homo sapiens_hsa034401.02136185
71Parkinsons disease_Homo sapiens_hsa050120.97441549
72Fat digestion and absorption_Homo sapiens_hsa049750.95715687
73Vitamin digestion and absorption_Homo sapiens_hsa049770.95319407
74Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.93985297
75Tyrosine metabolism_Homo sapiens_hsa003500.93452281
76AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.92673590
77Focal adhesion_Homo sapiens_hsa045100.92344286
78MicroRNAs in cancer_Homo sapiens_hsa052060.91950477
79Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.91406582
80Primary bile acid biosynthesis_Homo sapiens_hsa001200.91285985
81Axon guidance_Homo sapiens_hsa043600.90956262
82Prolactin signaling pathway_Homo sapiens_hsa049170.87164700
83Huntingtons disease_Homo sapiens_hsa050160.86840413
84Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.86201134
85Hepatitis C_Homo sapiens_hsa051600.86050805
86Fanconi anemia pathway_Homo sapiens_hsa034600.84986342
87GnRH signaling pathway_Homo sapiens_hsa049120.84876017
88Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.84749181
89NOD-like receptor signaling pathway_Homo sapiens_hsa046210.83793348
90Steroid biosynthesis_Homo sapiens_hsa001000.83268380
91Protein digestion and absorption_Homo sapiens_hsa049740.82438015
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.81930949
93TNF signaling pathway_Homo sapiens_hsa046680.81145880
94Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.80813434
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.77451388
96Autoimmune thyroid disease_Homo sapiens_hsa053200.75635534
97Endometrial cancer_Homo sapiens_hsa052130.75175870
98Glutamatergic synapse_Homo sapiens_hsa047240.73939416
99Wnt signaling pathway_Homo sapiens_hsa043100.73519988
100p53 signaling pathway_Homo sapiens_hsa041150.73503247
101Protein export_Homo sapiens_hsa030600.72888248
102Asthma_Homo sapiens_hsa053100.67715494
103Primary immunodeficiency_Homo sapiens_hsa053400.66744992
104Pathways in cancer_Homo sapiens_hsa052000.65319525
105Circadian entrainment_Homo sapiens_hsa047130.65246225
106Ras signaling pathway_Homo sapiens_hsa040140.64095351
107Gastric acid secretion_Homo sapiens_hsa049710.63975917
108Alzheimers disease_Homo sapiens_hsa050100.63599686
109Propanoate metabolism_Homo sapiens_hsa006400.63178590
110Prostate cancer_Homo sapiens_hsa052150.62638711
111RNA degradation_Homo sapiens_hsa030180.62448274
112Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.61542912
113Dorso-ventral axis formation_Homo sapiens_hsa043200.59907022
114Salmonella infection_Homo sapiens_hsa051320.59837220
115Pancreatic secretion_Homo sapiens_hsa049720.59594387
116Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.59294684
117Graft-versus-host disease_Homo sapiens_hsa053320.58870728
118Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.58696425
119Long-term depression_Homo sapiens_hsa047300.58664052
120Collecting duct acid secretion_Homo sapiens_hsa049660.58003427
121Metabolic pathways_Homo sapiens_hsa011000.57817218
122Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56877520
123Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.56846791
124Legionellosis_Homo sapiens_hsa051340.55581383
125Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.54911910
126Vibrio cholerae infection_Homo sapiens_hsa051100.53513525
127Glycerolipid metabolism_Homo sapiens_hsa005610.53372574
128Notch signaling pathway_Homo sapiens_hsa043300.53046963
129Sulfur relay system_Homo sapiens_hsa041220.53023314
130Vascular smooth muscle contraction_Homo sapiens_hsa042700.52584964
131Rap1 signaling pathway_Homo sapiens_hsa040150.51674045
132Steroid hormone biosynthesis_Homo sapiens_hsa001400.51563457
133Salivary secretion_Homo sapiens_hsa049700.51322199
134Rheumatoid arthritis_Homo sapiens_hsa053230.50778821
135Pancreatic cancer_Homo sapiens_hsa052120.50668228
136Calcium signaling pathway_Homo sapiens_hsa040200.49974376
137Estrogen signaling pathway_Homo sapiens_hsa049150.49530695
138Antigen processing and presentation_Homo sapiens_hsa046120.49425576
139Jak-STAT signaling pathway_Homo sapiens_hsa046300.49147726
140Malaria_Homo sapiens_hsa051440.48581291
141Insulin resistance_Homo sapiens_hsa049310.48302020
142Fatty acid degradation_Homo sapiens_hsa000710.48196003
143Platelet activation_Homo sapiens_hsa046110.47439607
144Sulfur metabolism_Homo sapiens_hsa009200.47202657
145Staphylococcus aureus infection_Homo sapiens_hsa051500.47087085
146One carbon pool by folate_Homo sapiens_hsa006700.46563764
147Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.44223431
148HTLV-I infection_Homo sapiens_hsa051660.43781690
149Cardiac muscle contraction_Homo sapiens_hsa042600.42832373
150Morphine addiction_Homo sapiens_hsa050320.42600437
151Apoptosis_Homo sapiens_hsa042100.42550305
152ABC transporters_Homo sapiens_hsa020100.40048689
153Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39960556
154ErbB signaling pathway_Homo sapiens_hsa040120.39872325
155Toll-like receptor signaling pathway_Homo sapiens_hsa046200.39225798
156Renin secretion_Homo sapiens_hsa049240.38406008
157Thyroid hormone synthesis_Homo sapiens_hsa049180.38392112
158Type I diabetes mellitus_Homo sapiens_hsa049400.37716268
159Insulin secretion_Homo sapiens_hsa049110.35732816
160Amphetamine addiction_Homo sapiens_hsa050310.33964729
161Fatty acid metabolism_Homo sapiens_hsa012120.33772926
162Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.32577168
163Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30035008
164Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.29084077

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