BNC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a zinc finger protein present in the basal cell layer of the epidermis and in hair follicles. It is also found in abundance in the germ cells of testis and ovary. This protein is thought to play a regulatory role in keratinocyte proliferation and it may also be a regulator for rRNA transcription. Alternative splicing of this gene results in multiple transcript variants, and multiple polyadenylation sites are indicated. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synapsis (GO:0007129)7.89816617
2hemidesmosome assembly (GO:0031581)7.09741321
3piRNA metabolic process (GO:0034587)6.93742366
4keratinocyte proliferation (GO:0043616)6.82116378
5bundle of His cell to Purkinje myocyte communication (GO:0086069)6.59530450
6establishment of skin barrier (GO:0061436)5.82267416
7meiosis I (GO:0007127)5.60265111
8DNA synthesis involved in DNA repair (GO:0000731)5.37920444
9regulation of water loss via skin (GO:0033561)5.28614448
10mitotic chromosome condensation (GO:0007076)5.22596697
11DNA methylation involved in gamete generation (GO:0043046)4.88495047
12regulation of meiosis I (GO:0060631)4.82935781
13synaptonemal complex assembly (GO:0007130)4.65140389
14regulation of transforming growth factor beta2 production (GO:0032909)4.61420641
15intermediate filament organization (GO:0045109)4.58238274
16mitotic metaphase plate congression (GO:0007080)4.50830924
17keratinization (GO:0031424)4.50729657
18male meiosis (GO:0007140)4.47934176
19cell adhesion mediated by integrin (GO:0033627)4.43569346
20regulation of sister chromatid cohesion (GO:0007063)4.40096212
21desmosome organization (GO:0002934)4.39504892
22regulation of female gonad development (GO:2000194)4.38535340
23attachment of spindle microtubules to kinetochore (GO:0008608)4.36985063
24female gamete generation (GO:0007292)4.34694035
25hair cycle (GO:0042633)4.29204630
26molting cycle (GO:0042303)4.29204630
27regulation of hair follicle development (GO:0051797)4.24282547
28meiotic chromosome segregation (GO:0045132)4.22864101
29synaptonemal complex organization (GO:0070193)4.12669729
30regulation of meiosis (GO:0040020)4.07761710
31gene silencing by RNA (GO:0031047)4.06983665
32metaphase plate congression (GO:0051310)4.05796182
33histone H3-K9 demethylation (GO:0033169)4.02713540
34negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.01373982
35endodermal cell differentiation (GO:0035987)3.96245934
36histone H3-K36 demethylation (GO:0070544)3.91453203
37mitotic sister chromatid cohesion (GO:0007064)3.90671762
38meiotic cell cycle (GO:0051321)3.90252379
39surfactant homeostasis (GO:0043129)3.89556463
40* epidermis development (GO:0008544)3.87414997
41histone H2A monoubiquitination (GO:0035518)3.85076875
42keratinocyte differentiation (GO:0030216)3.84822075
43negative regulation of chondrocyte differentiation (GO:0032331)3.83563223
44nuclear pore complex assembly (GO:0051292)3.81344702
45regulation of cardioblast differentiation (GO:0051890)3.79793091
46keratinocyte development (GO:0003334)3.76585771
47genitalia morphogenesis (GO:0035112)3.75625706
48chemical homeostasis within a tissue (GO:0048875)3.70349707
49gap junction assembly (GO:0016264)3.70348932
50oocyte development (GO:0048599)3.67195891
51establishment of planar polarity (GO:0001736)3.66903504
52establishment of tissue polarity (GO:0007164)3.66903504
53protein localization to kinetochore (GO:0034501)3.62328274
54regulation of hair cycle (GO:0042634)3.61804756
55mesodermal cell differentiation (GO:0048333)3.60781988
56regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.58397469
57negative regulation of meiosis (GO:0045835)3.54414710
58notochord development (GO:0030903)3.52753001
59paraxial mesoderm development (GO:0048339)3.50831925
60DNA alkylation (GO:0006305)3.49548839
61DNA methylation (GO:0006306)3.49548839
62monoubiquitinated protein deubiquitination (GO:0035520)3.48206327
63positive regulation of meiotic cell cycle (GO:0051446)3.48078790
64nuclear pore organization (GO:0006999)3.45137175
65oocyte maturation (GO:0001556)3.44384549
66DNA damage induced protein phosphorylation (GO:0006975)3.43413003
67establishment of chromosome localization (GO:0051303)3.40417963
68positive regulation of meiosis (GO:0045836)3.39133917
69protein localization to chromosome, centromeric region (GO:0071459)3.38033864
70diterpenoid biosynthetic process (GO:0016102)3.37432726
71positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.37212717
72positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.37212717
73positive regulation of mitotic sister chromatid separation (GO:1901970)3.37212717
74positive regulation of epidermis development (GO:0045684)3.37176097
75signal complex assembly (GO:0007172)3.36984738
76sister chromatid cohesion (GO:0007062)3.36104612
77negative regulation of keratinocyte proliferation (GO:0010839)3.34866849
78regulation of spindle organization (GO:0090224)3.33033492
79morphogenesis of embryonic epithelium (GO:0016331)3.33019421
80negative regulation of anoikis (GO:2000811)3.32889472
81cytoplasmic mRNA processing body assembly (GO:0033962)3.31765907
82reproductive system development (GO:0061458)3.30678831
83meiotic nuclear division (GO:0007126)3.25818878
84kinetochore organization (GO:0051383)3.25254952
85protein localization to chromosome (GO:0034502)3.25067401
86regulation of keratinocyte proliferation (GO:0010837)3.24717070
87positive regulation of chromosome segregation (GO:0051984)3.21788150
88positive regulation of epidermal cell differentiation (GO:0045606)3.20725234
89polarized epithelial cell differentiation (GO:0030859)3.20708302
90regulation of mitotic spindle organization (GO:0060236)3.20396847
91positive regulation of hair cycle (GO:0042635)3.19971718
92positive regulation of hair follicle development (GO:0051798)3.19971718
93regulation of meiotic cell cycle (GO:0051445)3.19571246
94mitotic sister chromatid segregation (GO:0000070)3.19462619
95oogenesis (GO:0048477)3.19198910
96mitotic nuclear envelope disassembly (GO:0007077)3.18954351
97multicellular organismal water homeostasis (GO:0050891)3.17201115
98dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.16557611
99regulation of retinoic acid receptor signaling pathway (GO:0048385)3.15842647
100ectoderm development (GO:0007398)3.13688143
101skin morphogenesis (GO:0043589)3.06539232
102membrane disassembly (GO:0030397)3.05683291
103nuclear envelope disassembly (GO:0051081)3.05683291
104hypotonic response (GO:0006971)3.05088056
105regulation of chromosome segregation (GO:0051983)3.04162112
106DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.04050827
107regulation of hippo signaling (GO:0035330)3.03678090
108chromosome organization involved in meiosis (GO:0070192)3.03593529
109spindle checkpoint (GO:0031577)3.02783648
110regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.02121661
111kinetochore assembly (GO:0051382)3.00589280
112histone H2A ubiquitination (GO:0033522)3.00512723
113sister chromatid segregation (GO:0000819)3.00457864
114negative regulation of smooth muscle cell differentiation (GO:0051151)2.99583755
115chromosome segregation (GO:0007059)2.96646010
116epidermal cell differentiation (GO:0009913)2.94810945
117negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.94438811
118meiotic cell cycle process (GO:1903046)2.92854198
119face development (GO:0060324)2.92152286
120embryonic body morphogenesis (GO:0010172)2.91677263
121gene silencing (GO:0016458)2.90563203
122female gonad development (GO:0008585)2.89167897
123atrioventricular valve morphogenesis (GO:0003181)2.86522957
124mitotic spindle checkpoint (GO:0071174)2.84484916
125cell-substrate junction assembly (GO:0007044)2.83197515
126growth hormone receptor signaling pathway (GO:0060396)2.79641511
127regulation of epidermis development (GO:0045682)2.79519955
128regulation of mitotic metaphase/anaphase transition (GO:0030071)2.78514015
129chromatin remodeling at centromere (GO:0031055)2.77380024
130negative regulation of meiotic cell cycle (GO:0051447)2.77083069
131DNA damage response, signal transduction resulting in transcription (GO:0042772)2.75602273
132male meiosis I (GO:0007141)2.75573891
133cell junction assembly (GO:0034329)2.73411500
134DNA replication-independent nucleosome assembly (GO:0006336)2.73184774
135DNA replication-independent nucleosome organization (GO:0034724)2.73184774
136histone exchange (GO:0043486)2.73056824
137nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.72885799
138vitamin A metabolic process (GO:0006776)2.72673955
139protein localization to endosome (GO:0036010)2.72170169
140regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.71936951
141mitotic spindle assembly checkpoint (GO:0007094)2.71815470
142peptide cross-linking (GO:0018149)2.71737322
143interkinetic nuclear migration (GO:0022027)2.68939362
144protein K6-linked ubiquitination (GO:0085020)2.68821651
145embryonic camera-type eye development (GO:0031076)2.68567211
146regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.68359171
147spindle assembly checkpoint (GO:0071173)2.68271549
148negative regulation of cartilage development (GO:0061037)2.67931940
149lateral sprouting from an epithelium (GO:0060601)2.67703497
150negative regulation of chromosome segregation (GO:0051985)2.67336172
151negative regulation of hormone biosynthetic process (GO:0032353)2.66973411
152negative regulation of hormone metabolic process (GO:0032351)2.66973411
153positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.66893789
154CENP-A containing nucleosome assembly (GO:0034080)2.66746767
155regulation of sister chromatid segregation (GO:0033045)2.66451367
156regulation of mitotic sister chromatid segregation (GO:0033047)2.66451367
157intermediate filament cytoskeleton organization (GO:0045104)2.66380746
158regulation of anoikis (GO:2000209)2.63859518
159neural crest cell development (GO:0014032)2.60671290
160endoderm development (GO:0007492)2.59491923
161establishment of epithelial cell polarity (GO:0090162)2.58400778
162skin development (GO:0043588)2.57490293
163intermediate filament-based process (GO:0045103)2.56587512
164cell junction organization (GO:0034330)2.55566482
165regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.50836366
166embryonic heart tube development (GO:0035050)2.49614300
167focal adhesion assembly (GO:0048041)2.48962091
168cell-substrate adherens junction assembly (GO:0007045)2.48962091
169extracellular matrix disassembly (GO:0022617)2.47695238
170water homeostasis (GO:0030104)2.47419705
171negative regulation of stem cell proliferation (GO:2000647)2.47086190
172negative regulation of epidermis development (GO:0045683)2.45768412
173epithelial cell-cell adhesion (GO:0090136)2.44057609
174regulation of NFAT protein import into nucleus (GO:0051532)2.43437528
175mating behavior (GO:0007617)2.42860321

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human9.02300310
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.94949447
3E2F7_22180533_ChIP-Seq_HELA_Human5.22415858
4AR_21909140_ChIP-Seq_LNCAP_Human3.97190571
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.70065323
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.54566635
7STAT6_21828071_ChIP-Seq_BEAS2B_Human3.32606608
8* SALL1_21062744_ChIP-ChIP_HESCs_Human2.96044755
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.53331593
10KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.42350296
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.33208335
12HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.26541888
13SMAD_19615063_ChIP-ChIP_OVARY_Human2.15381763
14SOX9_24532713_ChIP-Seq_HFSC_Mouse2.10167975
15RBPJ_22232070_ChIP-Seq_NCS_Mouse2.05769222
16TP63_19390658_ChIP-ChIP_HaCaT_Human2.04757925
17NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.00758551
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.88141908
19E2F1_21310950_ChIP-Seq_MCF-7_Human1.86920147
20TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.86405763
21FOXO3_23340844_ChIP-Seq_DLD1_Human1.79778916
22ESR1_20079471_ChIP-ChIP_T-47D_Human1.69121243
23MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.67594968
24STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.65990455
25* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.62989540
26* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.62989540
27CJUN_26792858_Chip-Seq_BT549_Human1.61753298
28FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.59628424
29TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.58710113
30FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.58485397
31TRIM28_21343339_ChIP-Seq_HEK293_Human1.57447846
32ATF3_27146783_Chip-Seq_COLON_Human1.56012703
33ESR1_21235772_ChIP-Seq_MCF-7_Human1.51949437
34SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.51621872
35BRD4_25478319_ChIP-Seq_HGPS_Human1.43215031
36PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.42934910
37RARG_19884340_ChIP-ChIP_MEFs_Mouse1.36341203
38* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.35764962
39TCF4_18268006_ChIP-ChIP_LS174T_Human1.34685329
40* UBF1/2_26484160_Chip-Seq_HMECs_Human1.31584533
41EGR1_19374776_ChIP-ChIP_THP-1_Human1.31433188
42TP53_18474530_ChIP-ChIP_U2OS_Human1.30172845
43* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.29676986
44KAP1_22055183_ChIP-Seq_ESCs_Mouse1.23103331
45* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.21036705
46* TP63_22573176_ChIP-Seq_HFKS_Human1.20124881
47CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.19459339
48SOX2_20726797_ChIP-Seq_SW620_Human1.19090975
49TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18090799
50* ISL1_27105846_Chip-Seq_CPCs_Mouse1.16663319
51CLOCK_20551151_ChIP-Seq_293T_Human1.16621059
52* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.16094717
53* TP63_23658742_ChIP-Seq_EP156T_Human1.15030990
54RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13879045
55FOXM1_26456572_ChIP-Seq_MCF-7_Human1.13807381
56TP53_16413492_ChIP-PET_HCT116_Human1.13664344
57RUNX1_26923725_Chip-Seq_HPCs_Mouse1.13092460
58RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.11719393
59HIF1A_21447827_ChIP-Seq_MCF-7_Human1.10560293
60CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.10207571
61PKCTHETA_26484144_Chip-Seq_BREAST_Human1.08741434
62ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.08597463
63CHD1_26751641_Chip-Seq_LNCaP_Human1.08502817
64ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.06876427
65ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.06857444
66TET1_21490601_ChIP-Seq_MESCs_Mouse1.06644533
67CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.06032398
68DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.05844902
69CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.05217365
70KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.04225195
71* CDX2_22108803_ChIP-Seq_LS180_Human1.04054479
72GATA6_25053715_ChIP-Seq_YYC3_Human1.03486062
73PPAR_26484153_Chip-Seq_NCI-H1993_Human1.03418083
74GATA1_26923725_Chip-Seq_HPCs_Mouse1.02377703
75HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.02171952
76AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01590747
77EP300_21415370_ChIP-Seq_HL-1_Mouse1.01391846
78KLF4_18555785_ChIP-Seq_MESCs_Mouse1.01035359
79* GATA2_21666600_ChIP-Seq_HMVEC_Human1.00734442
80* ELK3_25401928_ChIP-Seq_HUVEC_Human0.98655495
81RUNX1_27514584_Chip-Seq_MCF-7_Human0.97196669
82* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96922577
83SALL4_18804426_ChIP-ChIP_XEN_Mouse0.96746395
84NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.96033924
85* RNF2_27304074_Chip-Seq_NSC_Mouse0.94683078
86MYCN_18555785_ChIP-Seq_MESCs_Mouse0.93653555
87* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.93322728
88NANOG_21062744_ChIP-ChIP_HESCs_Human0.93089318
89WT1_19549856_ChIP-ChIP_CCG9911_Human0.91638584
90SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.90852489
91FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.89721605
92WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.89697690
93TBX20_22328084_ChIP-Seq_HEART_Mouse0.89178093
94TBX20_22080862_ChIP-Seq_HEART_Mouse0.89178093
95SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.88612000
96FUS_26573619_Chip-Seq_HEK293_Human0.87234631
97TP53_22127205_ChIP-Seq_IMR90_Human0.87045060
98GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.87031716
99TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.86982796
100CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.86817204
101TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.85917139
102RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.85188562
103NELFA_20434984_ChIP-Seq_ESCs_Mouse0.84928152
104PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.84546731
105EWS_26573619_Chip-Seq_HEK293_Human0.83692859
106UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.83648920
107KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.82925716
108PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.82509568
109* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.81781293
110EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.81441525
111MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.81165115
112ZFX_18555785_ChIP-Seq_MESCs_Mouse0.81107701
113KLF5_25053715_ChIP-Seq_YYC3_Human0.80576562
114ESR2_21235772_ChIP-Seq_MCF-7_Human0.80413412
115EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.79649499
116SOX2_27498859_Chip-Seq_STOMACH_Mouse0.79605275
117PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.79379477
118BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.79108935
119ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.78941344
120* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78274987
121* GATA3_24758297_ChIP-Seq_MCF-7_Human0.77407444
122MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.76862726
123NFYA_21822215_ChIP-Seq_K562_Human0.76664034
124ZNF263_19887448_ChIP-Seq_K562_Human0.75623043
125KDM2B_26808549_Chip-Seq_JURKAT_Human0.74995650
126DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.74012286
127AHR_22903824_ChIP-Seq_MCF-7_Human0.73775318
128CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.72644167
129TP53_23651856_ChIP-Seq_MEFs_Mouse0.71724741
130* BMI1_23680149_ChIP-Seq_NPCS_Mouse0.67854536
131GATA4_25053715_ChIP-Seq_YYC3_Human0.63970147
132PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.63766074
133POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.63192353
134SMAD3_21741376_ChIP-Seq_HESCs_Human0.63109527
135EGR1_19032775_ChIP-ChIP_M12_Human0.61911073
136PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.60211712
137TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.59863045
138ARNT_22903824_ChIP-Seq_MCF-7_Human0.58380670
139RACK7_27058665_Chip-Seq_MCF-7_Human0.57610645
140RXR_22108803_ChIP-Seq_LS180_Human0.55813652
141ETV1_20927104_ChIP-Seq_GIST48_Human0.55457496
142ELK4_26923725_Chip-Seq_MESODERM_Mouse0.55444771

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000579_abnormal_nail_morphology4.12273269
2MP0003705_abnormal_hypodermis_morpholog3.43202510
3MP0005409_darkened_coat_color3.19554792
4MP0000383_abnormal_hair_follicle3.03986941
5MP0008877_abnormal_DNA_methylation3.00137546
6MP0010234_abnormal_vibrissa_follicle2.70171494
7MP0010678_abnormal_skin_adnexa2.66844450
8MP0005275_abnormal_skin_tensile2.54032995
9MP0010368_abnormal_lymphatic_system2.53349385
10MP0000678_abnormal_parathyroid_gland2.49484396
11MP0000427_abnormal_hair_cycle2.39384746
12MP0003718_maternal_effect2.39034791
13MP0002254_reproductive_system_inflammat2.31696429
14MP0002796_impaired_skin_barrier2.31010731
15MP0003950_abnormal_plasma_membrane2.21109313
16MP0002098_abnormal_vibrissa_morphology2.19020733
17MP0001849_ear_inflammation2.17782198
18MP0010094_abnormal_chromosome_stability2.13671716
19MP0002060_abnormal_skin_morphology2.09993873
20MP0003693_abnormal_embryo_hatching2.06381808
21MP0003453_abnormal_keratinocyte_physiol2.00001482
22MP0003123_paternal_imprinting1.99186253
23MP0000647_abnormal_sebaceous_gland1.96783936
24MP0008260_abnormal_autophagy1.95229282
25MP0010030_abnormal_orbit_morphology1.95064320
26MP0003937_abnormal_limbs/digits/tail_de1.92001417
27MP0003941_abnormal_skin_development1.87923114
28MP0003111_abnormal_nucleus_morphology1.86748067
29MP0001216_abnormal_epidermal_layer1.84942207
30MP0004381_abnormal_hair_follicle1.80821537
31MP0004957_abnormal_blastocyst_morpholog1.80621806
32MP0005451_abnormal_body_composition1.78569087
33MP0003077_abnormal_cell_cycle1.75205432
34MP0000377_abnormal_hair_follicle1.75018781
35MP0002234_abnormal_pharynx_morphology1.71178331
36MP0000566_synostosis1.69371467
37MP0003566_abnormal_cell_adhesion1.66947228
38MP0009053_abnormal_anal_canal1.63907812
39MP0008007_abnormal_cellular_replicative1.63267804
40MP0004185_abnormal_adipocyte_glucose1.62548490
41MP0000762_abnormal_tongue_morphology1.62039924
42MP0000467_abnormal_esophagus_morphology1.57986259
43MP0001346_abnormal_lacrimal_gland1.55173814
44MP0003121_genomic_imprinting1.53961395
45MP0002249_abnormal_larynx_morphology1.50036968
46MP0002210_abnormal_sex_determination1.49872648
47MP0010352_gastrointestinal_tract_polyps1.46864789
48MP0003755_abnormal_palate_morphology1.46604777
49MP0009384_cardiac_valve_regurgitation1.46314232
50MP0001119_abnormal_female_reproductive1.44647658
51MP0005501_abnormal_skin_physiology1.44204721
52MP0000537_abnormal_urethra_morphology1.34132082
53MP0003315_abnormal_perineum_morphology1.33502605
54MP0002102_abnormal_ear_morphology1.31523567
55MP0000653_abnormal_sex_gland1.30776399
56MP0003699_abnormal_female_reproductive1.29367601
57MP0003385_abnormal_body_wall1.29307192
58MP0005076_abnormal_cell_differentiation1.29115442
59MP0005257_abnormal_intraocular_pressure1.28369182
60MP0009250_abnormal_appendicular_skeleto1.27093864
61MP0001929_abnormal_gametogenesis1.26319995
62MP0003787_abnormal_imprinting1.25869275
63MP0001730_embryonic_growth_arrest1.25634159
64MP0000350_abnormal_cell_proliferation1.25013922
65MP0010771_integument_phenotype1.24823834
66MP0002084_abnormal_developmental_patter1.24479774
67MP0002085_abnormal_embryonic_tissue1.23735990
68MP0008932_abnormal_embryonic_tissue1.22411728
69MP0003935_abnormal_craniofacial_develop1.22067720
70MP0000733_abnormal_muscle_development1.21811409
71MP0002877_abnormal_melanocyte_morpholog1.20238357
72MP0000432_abnormal_head_morphology1.19725598
73MP0005395_other_phenotype1.19481464
74MP0002653_abnormal_ependyma_morphology1.18010868
75MP0001661_extended_life_span1.17225755
76MP0000462_abnormal_digestive_system1.14189483
77MP0008057_abnormal_DNA_replication1.09807624
78MP0004264_abnormal_extraembryonic_tissu1.09177801
79MP0001851_eye_inflammation1.08262444
80MP0008789_abnormal_olfactory_epithelium1.06916133
81MP0001879_abnormal_lymphatic_vessel1.05413102
82MP0001697_abnormal_embryo_size1.03363592
83MP0001340_abnormal_eyelid_morphology1.03169209
84MP0002160_abnormal_reproductive_system1.03060315
85MP0004272_abnormal_basement_membrane1.02674340
86MP0002282_abnormal_trachea_morphology1.01455264
87MP0005248_abnormal_Harderian_gland1.01450844
88MP0002233_abnormal_nose_morphology1.00908823
89MP0002932_abnormal_joint_morphology1.00870857
90MP0000428_abnormal_craniofacial_morphol1.00855110
91MP0001672_abnormal_embryogenesis/_devel1.00388090
92MP0005380_embryogenesis_phenotype1.00388090
93MP0005408_hypopigmentation1.00049638
94MP0001145_abnormal_male_reproductive0.99888964
95MP0008438_abnormal_cutaneous_collagen0.99149902
96MP0001915_intracranial_hemorrhage0.97346232
97MP0000627_abnormal_mammary_gland0.96269130
98MP0001191_abnormal_skin_condition0.95871937
99MP0009780_abnormal_chondrocyte_physiolo0.95545263
100MP0004782_abnormal_surfactant_physiolog0.94985072
101MP0005508_abnormal_skeleton_morphology0.94777725
102MP0001243_abnormal_dermal_layer0.94729150
103MP0004233_abnormal_muscle_weight0.93715278
104MP0001299_abnormal_eye_distance/0.93571162
105MP0000013_abnormal_adipose_tissue0.92902784
106MP0003786_premature_aging0.92248360
107MP0005623_abnormal_meninges_morphology0.91359026
108MP0002177_abnormal_outer_ear0.90608143
109MP0003191_abnormal_cellular_cholesterol0.90295513
110MP0000569_abnormal_digit_pigmentation0.90010554
111MP0008995_early_reproductive_senescence0.89883215
112MP0002116_abnormal_craniofacial_bone0.85693471
113MP0003115_abnormal_respiratory_system0.85002832
114* MP0005023_abnormal_wound_healing0.84706155
115MP0002111_abnormal_tail_morphology0.84655005
116MP0009931_abnormal_skin_appearance0.84148731
117MP0003984_embryonic_growth_retardation0.83793483
118MP0003646_muscle_fatigue0.83371373
119MP0005360_urolithiasis0.82408810
120MP0002088_abnormal_embryonic_growth/wei0.81704930
121MP0000367_abnormal_coat/_hair0.80974626
122MP0005389_reproductive_system_phenotype0.79879095
123MP0002109_abnormal_limb_morphology0.79442941
124MP0001958_emphysema0.77549745
125MP0002089_abnormal_postnatal_growth/wei0.76723666
126MP0004947_skin_inflammation0.71664588
127MP0002896_abnormal_bone_mineralization0.70099479
128MP0003091_abnormal_cell_migration0.69790479
129MP0004019_abnormal_vitamin_homeostasis0.66001897
130MP0003936_abnormal_reproductive_system0.65000155
131MP0005499_abnormal_olfactory_system0.63782775
132MP0005394_taste/olfaction_phenotype0.63782775
133MP0003698_abnormal_male_reproductive0.63759469
134MP0003828_pulmonary_edema0.58756604
135MP0003119_abnormal_digestive_system0.58367763
136MP0000767_abnormal_smooth_muscle0.58011390
137MP0000003_abnormal_adipose_tissue0.57386483
138MP0008058_abnormal_DNA_repair0.55831401
139MP0000015_abnormal_ear_pigmentation0.53833108
140MP0002697_abnormal_eye_size0.53424280
141MP0004885_abnormal_endolymph0.53202162
142MP0005197_abnormal_uvea_morphology0.52570795
143MP0002086_abnormal_extraembryonic_tissu0.52462615

Predicted human phenotypes

RankGene SetZ-score
1Milia (HP:0001056)6.16954218
2Fragile nails (HP:0001808)5.09003802
3Onycholysis (HP:0001806)4.63815579
4Atrophic scars (HP:0001075)4.56987751
5Pili torti (HP:0003777)4.42824795
6Plantar hyperkeratosis (HP:0007556)3.72286560
7Male infertility (HP:0003251)3.71692154
8Papillary thyroid carcinoma (HP:0002895)3.60407067
9Hypotrichosis (HP:0001006)3.46037001
10Woolly hair (HP:0002224)3.41398435
11Shallow orbits (HP:0000586)3.25206162
12Shoulder girdle muscle weakness (HP:0003547)3.19810032
13Lip pit (HP:0100267)3.19235814
14Amniotic constriction ring (HP:0009775)3.18268726
15Abnormality of placental membranes (HP:0011409)3.18268726
16Nail dystrophy (HP:0008404)3.13661359
17Ankle contracture (HP:0006466)2.99540932
18Abnormality of nail color (HP:0100643)2.96652022
19Facial hemangioma (HP:0000329)2.96435152
20Amelogenesis imperfecta (HP:0000705)2.87035491
21Popliteal pterygium (HP:0009756)2.86744022
22Sparse eyelashes (HP:0000653)2.84731609
23Short nail (HP:0001799)2.84704339
24Right ventricular cardiomyopathy (HP:0011663)2.84088428
25Selective tooth agenesis (HP:0001592)2.78978725
26Ankyloglossia (HP:0010296)2.73984233
27Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.71868278
28Short 4th metacarpal (HP:0010044)2.71868278
29Thick nail (HP:0001805)2.71056256
30Abnormality of the labia minora (HP:0012880)2.70361658
31Absent eyelashes (HP:0000561)2.65488154
32Abnormal hair laboratory examination (HP:0003328)2.63271609
33Hypodontia (HP:0000668)2.60460683
34Abnormality of the salivary glands (HP:0010286)2.58115152
35Chromsome breakage (HP:0040012)2.45250625
36Shawl scrotum (HP:0000049)2.44770192
37Aplasia cutis congenita (HP:0001057)2.44523870
38Follicular hyperkeratosis (HP:0007502)2.42692542
39Abnormality of the lower motor neuron (HP:0002366)2.41061097
40Corneal erosion (HP:0200020)2.39140770
41Alopecia of scalp (HP:0002293)2.37763783
42Abnormality of the neuromuscular junction (HP:0003398)2.35447681
43Fatigable weakness (HP:0003473)2.35447681
44Dry hair (HP:0011359)2.34327244
45Blepharitis (HP:0000498)2.34232618
46Oligodactyly (HP:0012165)2.33772452
47Anonychia (HP:0001798)2.30756852
48Oligodontia (HP:0000677)2.28896328
49Wrist flexion contracture (HP:0001239)2.27182742
50Abnormal blistering of the skin (HP:0008066)2.25600184
51Palmoplantar hyperkeratosis (HP:0000972)2.23202747
52Abnormality of oral frenula (HP:0000190)2.21880566
53Hypoplastic labia majora (HP:0000059)2.19080941
54Natal tooth (HP:0000695)2.16826488
55Abnormality of the axillary hair (HP:0100134)2.15217283
56Abnormality of secondary sexual hair (HP:0009888)2.15217283
57Abnormality of the distal phalanx of the thumb (HP:0009617)2.14831738
58Palmar hyperkeratosis (HP:0010765)2.14386585
59Protrusio acetabuli (HP:0003179)2.13565552
60Carious teeth (HP:0000670)2.13115386
61Palmoplantar keratoderma (HP:0000982)2.12346202
62Abnormality of the fingertips (HP:0001211)2.12266024
63Fragile skin (HP:0001030)2.10452435
64Abnormality of the 4th metacarpal (HP:0010012)2.09812389
65Abnormality of the dental root (HP:0006486)2.09263410
66Taurodontia (HP:0000679)2.09263410
67Abnormality of permanent molar morphology (HP:0011071)2.09263410
68Breast hypoplasia (HP:0003187)2.08836030
69Poikiloderma (HP:0001029)2.08086121
70Erythema (HP:0010783)2.06821238
71Abnormality of the parietal bone (HP:0002696)2.06589852
72Cortical dysplasia (HP:0002539)2.05835598
73Vertebral arch anomaly (HP:0008438)2.02992073
74Oligodactyly (hands) (HP:0001180)2.02916972
75Abnormality of molar (HP:0011077)2.02878827
76Abnormality of molar morphology (HP:0011070)2.02878827
77Thin bony cortex (HP:0002753)2.02599532
78Abnormality of the labia majora (HP:0012881)2.02002392
79Sandal gap (HP:0001852)2.01117139
80Upper motor neuron abnormality (HP:0002127)2.00230706
81Chromosomal breakage induced by crosslinking agents (HP:0003221)1.99531888
82Microglossia (HP:0000171)1.99438365
83Hoarse voice (HP:0001609)1.98742330
84Acute myeloid leukemia (HP:0004808)1.98575970
85Premature rupture of membranes (HP:0001788)1.98445782
86Osteomalacia (HP:0002749)1.97415509
87Arterial tortuosity (HP:0005116)1.97415495
88Skin pits (HP:0100276)1.97233983
89Capillary hemangiomas (HP:0005306)1.96753630
90Sparse scalp hair (HP:0002209)1.95461505
91Abnormality of chromosome segregation (HP:0002916)1.94702305
92Patellar aplasia (HP:0006443)1.93882345
93Abnormality of the aortic arch (HP:0012303)1.93530856
94Hypoplasia of dental enamel (HP:0006297)1.92068499
95Deviation of the thumb (HP:0009603)1.91385860
96Aplasia/Hypoplasia of the sternum (HP:0006714)1.91087477
97Thyroid carcinoma (HP:0002890)1.89824318
98Birth length less than 3rd percentile (HP:0003561)1.87860848
99Hyperhidrosis (HP:0000975)1.87557978
100Ridged nail (HP:0001807)1.83179406
101Esophageal atresia (HP:0002032)1.83046650
102Aplasia/Hypoplasia of the patella (HP:0006498)1.82977781
103Xerostomia (HP:0000217)1.82479482
104Abnormality of the dental pulp (HP:0006479)1.80420290
105Congenital ichthyosiform erythroderma (HP:0007431)1.79128953
106Hydroureter (HP:0000072)1.79076799
107Advanced eruption of teeth (HP:0006288)1.78889790
108Rectal prolapse (HP:0002035)1.77589311
109Ectopic kidney (HP:0000086)1.75783655
110Vascular tortuosity (HP:0004948)1.75177038
111Azoospermia (HP:0000027)1.74658663
112Erythroderma (HP:0001019)1.74463496
113Ectropion (HP:0000656)1.73908952
114Abnormality of the fingernails (HP:0001231)1.72207839
115Horizontal nystagmus (HP:0000666)1.71212991
116Enlarged penis (HP:0000040)1.70699385
117Adrenal hypoplasia (HP:0000835)1.69355588
118Cardiovascular calcification (HP:0011915)1.69258539
119Laryngomalacia (HP:0001601)1.68954590
120Midline defect of the nose (HP:0004122)1.68900080
121Abnormality of the phalanges of the hallux (HP:0010057)1.68398061
122Aortic dissection (HP:0002647)1.68192336
123Proximal placement of thumb (HP:0009623)1.66770585
124Premature ovarian failure (HP:0008209)1.66227457
125Sparse lateral eyebrow (HP:0005338)1.64882813
126Small intestinal stenosis (HP:0012848)1.63861028
127Duodenal stenosis (HP:0100867)1.63861028
128Vascular calcification (HP:0004934)1.62661207
129Non-midline cleft lip (HP:0100335)1.62534689
130Trismus (HP:0000211)1.62233211
131Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.60082009
132Broad thumb (HP:0011304)1.59694415
133Abnormality of the nasal septum (HP:0000419)1.59090301
134Ventricular tachycardia (HP:0004756)1.58474431
135Labial hypoplasia (HP:0000066)1.58189826
136Colon cancer (HP:0003003)1.58163349
137Neonatal death (HP:0003811)1.57636689
138Pterygium (HP:0001059)1.56453132
139Volvulus (HP:0002580)1.56416670
140Mitral valve prolapse (HP:0001634)1.55192712
141Medulloblastoma (HP:0002885)1.55108439
142Squamous cell carcinoma (HP:0002860)1.54514563
143Abnormality of the labia (HP:0000058)1.53648775
144Periodontitis (HP:0000704)1.53344741
145Aplasia involving bones of the upper limbs (HP:0009823)1.53130852
146Aplasia of the phalanges of the hand (HP:0009802)1.53130852
147Aplasia involving bones of the extremities (HP:0009825)1.53130852
148Autoamputation (HP:0001218)1.52532980
149Curly hair (HP:0002212)1.52274547
150Flat capital femoral epiphysis (HP:0003370)1.52248928
151Aplasia/Hypoplasia of the earlobes (HP:0009906)1.51791464
152Rhabdomyosarcoma (HP:0002859)1.51787759
153Trigonocephaly (HP:0000243)1.51584887
154Hypoplastic female external genitalia (HP:0012815)1.50870474
155Synostosis of carpal bones (HP:0005048)1.50865054
156Oral leukoplakia (HP:0002745)1.50632126
157Hypohidrosis (HP:0000966)1.49910268
158Duplicated collecting system (HP:0000081)1.47430154
15911 pairs of ribs (HP:0000878)1.46675142
160Recurrent corneal erosions (HP:0000495)1.46618936
161Cheilitis (HP:0100825)1.46477005
162Tibial bowing (HP:0002982)1.44521544
163Neurofibrillary tangles (HP:0002185)1.44399781

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS16.15800781
2PNCK5.64764741
3LATS24.34730396
4STK38L3.61351045
5ARAF3.22496856
6CDC73.16479968
7MAP3K63.01346419
8CDK122.49060127
9STK32.48683775
10TTK2.43834666
11EEF2K2.39726526
12PLK42.27229617
13CDK192.20757191
14MOS2.06670977
15BMX2.06345276
16PTK2B2.04014024
17NTRK11.97200416
18CAMK1G1.93976096
19ERBB41.93180048
20TAOK31.92424905
21TAOK11.85168442
22KSR21.80401344
23NEK21.74207798
24MAPKAPK31.67584540
25ACVR1B1.65933400
26FGR1.64588831
27FLT31.59589053
28TRIB31.55610658
29CDK91.55187764
30DMPK1.53563118
31MELK1.53049253
32CDK81.47071351
33CSF1R1.46941161
34STK101.44925987
35TGFBR21.44340138
36PIM21.37808897
37CHEK21.36076321
38BRAF1.26078178
39PLK11.24362974
40MAP3K91.21019322
41PRKD31.18320602
42PAK41.16044516
43RPS6KA41.15762136
44BMPR21.11584752
45TYRO31.10412715
46EPHB21.10196950
47RAF11.09942823
48RPS6KB21.08712572
49LMTK21.04992678
50AURKB1.04411932
51TRPM71.03920522
52MAP3K80.99957037
53CDK60.98847757
54FER0.96179066
55PLK20.95228576
56RET0.90527160
57KSR10.87931452
58CDK40.86943167
59SIK10.86720133
60MST1R0.85461350
61TESK10.84789953
62STK380.84618630
63CHEK10.82527768
64TTN0.81341006
65PKN20.80100909
66PDGFRA0.79152028
67ATM0.77630286
68MAP3K30.77110899
69EPHA30.76973556
70NLK0.76444764
71MTOR0.76247295
72MAP3K120.76014247
73STK240.75557180
74PRKCI0.75542409
75CDK70.73959191
76ERN10.70186829
77RIPK10.68426573
78PTK20.68093853
79CSNK1G10.67650614
80NEK10.67643802
81EPHA20.66501103
82MET0.65754350
83MUSK0.65310891
84TIE10.63371607
85ROCK10.63007103
86PLK30.62196480
87MAP3K40.61856687
88NUAK10.60255854
89WNK10.59597353
90RPS6KA20.57904815
91PDGFRB0.57123152
92DYRK20.57065444
93BRSK20.56793922
94PBK0.56489124
95TGFBR10.55832147
96ABL20.55424944
97PAK60.54587019
98PRKD20.54059998
99CAMK1D0.52382314
100ATR0.50207559
101DYRK30.49940589
102FGFR20.49720855
103NEK90.49154585
104LRRK20.48224973
105CDK10.47736942
106EPHB10.47325334
107CDK20.46984708
108MAP3K20.46901507
109RPS6KB10.46700086
110PTK60.46698987
111MYLK0.46540032
112EGFR0.44668302
113ROCK20.44018577
114CDK30.42415648
115NEK60.41766147
116PAK20.41287671
117PRKAA20.39613316
118FGFR10.39171380
119PDK20.37701070
120BCR0.37315908
121BRSK10.36475181
122MAP3K130.36149332
123CSNK1A1L0.35764301
124OXSR10.35419544
125AURKA0.35098298
126PRKAA10.33395920
127ABL10.32720937
128MAPKAPK50.32040759
129SRPK10.31907304
130MAP3K100.31385907
131CSNK1D0.30872305
132ERBB20.30484891
133BMPR1B0.30347408
134MAP3K50.30290277
135DDR20.30155208
136MAP2K20.28999283
137SMG10.27922720
138ADRBK10.23175285
139IGF1R0.22566293
140RPS6KA10.22492922
141PRPF4B0.19354794
142MAP2K10.18120943
143INSR0.17666939
144ILK0.17066160

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041103.43759518
2TGF-beta signaling pathway_Homo sapiens_hsa043502.57062939
3Basal transcription factors_Homo sapiens_hsa030222.53793289
4Basal cell carcinoma_Homo sapiens_hsa052172.36931568
5Hippo signaling pathway_Homo sapiens_hsa043902.27745866
6RNA degradation_Homo sapiens_hsa030182.25229504
7p53 signaling pathway_Homo sapiens_hsa041152.23337851
8Adherens junction_Homo sapiens_hsa045202.20293017
9MicroRNAs in cancer_Homo sapiens_hsa052062.15627076
10Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.04957457
11Small cell lung cancer_Homo sapiens_hsa052222.01887271
12Pancreatic cancer_Homo sapiens_hsa052122.01387844
13ECM-receptor interaction_Homo sapiens_hsa045121.99611805
14Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.98417556
15RNA transport_Homo sapiens_hsa030131.95950776
16Dorso-ventral axis formation_Homo sapiens_hsa043201.95073346
17Ovarian steroidogenesis_Homo sapiens_hsa049131.93973004
18Hedgehog signaling pathway_Homo sapiens_hsa043401.92088341
19Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.91862384
20Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.90489677
21Oocyte meiosis_Homo sapiens_hsa041141.89932981
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.88837867
23Thyroid cancer_Homo sapiens_hsa052161.74022092
24Circadian rhythm_Homo sapiens_hsa047101.73124289
25Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.57963963
26Homologous recombination_Homo sapiens_hsa034401.55448319
27Proteoglycans in cancer_Homo sapiens_hsa052051.48955122
28Colorectal cancer_Homo sapiens_hsa052101.46230918
29Fanconi anemia pathway_Homo sapiens_hsa034601.45787290
30Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.43847474
31mRNA surveillance pathway_Homo sapiens_hsa030151.42690851
32N-Glycan biosynthesis_Homo sapiens_hsa005101.41677438
33Focal adhesion_Homo sapiens_hsa045101.38559900
34Endometrial cancer_Homo sapiens_hsa052131.31059688
35Bladder cancer_Homo sapiens_hsa052191.30284702
36Wnt signaling pathway_Homo sapiens_hsa043101.24906117
37Renal cell carcinoma_Homo sapiens_hsa052111.24013583
38HTLV-I infection_Homo sapiens_hsa051661.22784568
39Notch signaling pathway_Homo sapiens_hsa043301.22567306
40Tight junction_Homo sapiens_hsa045301.19924251
41Chronic myeloid leukemia_Homo sapiens_hsa052201.17162740
42Amoebiasis_Homo sapiens_hsa051461.16148628
43Steroid biosynthesis_Homo sapiens_hsa001001.15766729
44Pathways in cancer_Homo sapiens_hsa052001.12627046
45Prostate cancer_Homo sapiens_hsa052151.11234996
46Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.09344496
47Thyroid hormone signaling pathway_Homo sapiens_hsa049191.07009897
48Linoleic acid metabolism_Homo sapiens_hsa005911.06948273
49Lysine degradation_Homo sapiens_hsa003101.04424067
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.03639639
51Prolactin signaling pathway_Homo sapiens_hsa049171.03202945
52VEGF signaling pathway_Homo sapiens_hsa043701.02493633
53mTOR signaling pathway_Homo sapiens_hsa041501.00946301
54FoxO signaling pathway_Homo sapiens_hsa040680.99654132
55Non-homologous end-joining_Homo sapiens_hsa034500.98285541
56Toxoplasmosis_Homo sapiens_hsa051450.94631391
57Non-small cell lung cancer_Homo sapiens_hsa052230.93189994
58Base excision repair_Homo sapiens_hsa034100.91879426
59GnRH signaling pathway_Homo sapiens_hsa049120.91826752
60Endocytosis_Homo sapiens_hsa041440.90969359
61Prion diseases_Homo sapiens_hsa050200.90069440
62Nucleotide excision repair_Homo sapiens_hsa034200.89728914
63Transcriptional misregulation in cancer_Homo sapiens_hsa052020.88745678
64Sphingolipid metabolism_Homo sapiens_hsa006000.86735397
65Melanogenesis_Homo sapiens_hsa049160.85338039
66DNA replication_Homo sapiens_hsa030300.85164073
67Regulation of actin cytoskeleton_Homo sapiens_hsa048100.83305215
68Choline metabolism in cancer_Homo sapiens_hsa052310.82813453
69Ether lipid metabolism_Homo sapiens_hsa005650.82185701
70Melanoma_Homo sapiens_hsa052180.81904746
71Herpes simplex infection_Homo sapiens_hsa051680.81371862
72Salmonella infection_Homo sapiens_hsa051320.81025666
73Glioma_Homo sapiens_hsa052140.79521492
74Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.77491216
75AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.77201773
76Inositol phosphate metabolism_Homo sapiens_hsa005620.76346185
77Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.76223055
78Sulfur relay system_Homo sapiens_hsa041220.74663798
79Mismatch repair_Homo sapiens_hsa034300.73969938
80Insulin signaling pathway_Homo sapiens_hsa049100.73689359
81Viral carcinogenesis_Homo sapiens_hsa052030.73145504
82Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71510084
83Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.70848442
84Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.69974940
85RNA polymerase_Homo sapiens_hsa030200.69827195
86Regulation of autophagy_Homo sapiens_hsa041400.67533755
87Longevity regulating pathway - mammal_Homo sapiens_hsa042110.66593855
88Spliceosome_Homo sapiens_hsa030400.65480700
89Axon guidance_Homo sapiens_hsa043600.65090988
90Estrogen signaling pathway_Homo sapiens_hsa049150.63122629
91Gap junction_Homo sapiens_hsa045400.61566427
92Ras signaling pathway_Homo sapiens_hsa040140.61067855
93Hepatitis B_Homo sapiens_hsa051610.60830338
94PI3K-Akt signaling pathway_Homo sapiens_hsa041510.59687968
95Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58236500
96Viral myocarditis_Homo sapiens_hsa054160.57224232
97ErbB signaling pathway_Homo sapiens_hsa040120.56820942
98TNF signaling pathway_Homo sapiens_hsa046680.54407451
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.53360359
100Rap1 signaling pathway_Homo sapiens_hsa040150.53343581
101Shigellosis_Homo sapiens_hsa051310.51812712
102Vitamin B6 metabolism_Homo sapiens_hsa007500.51786169
103Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.51774198
104AMPK signaling pathway_Homo sapiens_hsa041520.50160712
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.48961207
106Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.48542615
107Central carbon metabolism in cancer_Homo sapiens_hsa052300.48357160
108Insulin resistance_Homo sapiens_hsa049310.47272727
109Leukocyte transendothelial migration_Homo sapiens_hsa046700.46518880
110Epstein-Barr virus infection_Homo sapiens_hsa051690.46101745
111Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.44956385
112Platelet activation_Homo sapiens_hsa046110.44247300
113Acute myeloid leukemia_Homo sapiens_hsa052210.43903395
114Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.43790221
115Protein digestion and absorption_Homo sapiens_hsa049740.42444884
116Phenylalanine metabolism_Homo sapiens_hsa003600.41053747
117MAPK signaling pathway_Homo sapiens_hsa040100.40218798
118Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.39704490
119Dilated cardiomyopathy_Homo sapiens_hsa054140.38705934
120Neurotrophin signaling pathway_Homo sapiens_hsa047220.38637559
121Sulfur metabolism_Homo sapiens_hsa009200.38257456
122Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.37632190
123Phospholipase D signaling pathway_Homo sapiens_hsa040720.37347278
124Jak-STAT signaling pathway_Homo sapiens_hsa046300.36637152
125Apoptosis_Homo sapiens_hsa042100.36507384
126Glucagon signaling pathway_Homo sapiens_hsa049220.33973063
127Galactose metabolism_Homo sapiens_hsa000520.33339894
128Fatty acid biosynthesis_Homo sapiens_hsa000610.33265210

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