BMP15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate subunits of a disulfide-linked homodimer, or alternatively, a heterodimer, with the related protein, growth differentiation factor 9 (GDF9). This protein plays a role in oocyte maturation and follicular development, through activation of granulosa cells. Defects in this gene are the cause of ovarian dysgenesis and are associated with premature ovarian failure. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of female gonad development (GO:2000194)9.67552529
2binding of sperm to zona pellucida (GO:0007339)8.70100035
3piRNA metabolic process (GO:0034587)8.61134506
4regulation of phospholipid biosynthetic process (GO:0071071)7.85648567
5positive regulation of inflammatory response to antigenic stimulus (GO:0002863)7.60255389
6regulation of acute inflammatory response to antigenic stimulus (GO:0002864)6.75673582
7regulation of calcium ion-dependent exocytosis (GO:0017158)6.72327563
8sperm-egg recognition (GO:0035036)6.50884405
9regulation of meiosis (GO:0040020)6.47988860
10single fertilization (GO:0007338)6.46483399
11mitotic metaphase plate congression (GO:0007080)6.35200167
12citrulline metabolic process (GO:0000052)6.18376404
13fertilization (GO:0009566)6.13649906
14mitotic chromosome condensation (GO:0007076)5.85335277
15regulation of histone H3-K9 methylation (GO:0051570)5.73198687
16negative regulation of meiosis (GO:0045835)5.57260416
17positive regulation of reproductive process (GO:2000243)5.55383327
18meiotic cell cycle (GO:0051321)5.47162133
19negative regulation of retinoic acid receptor signaling pathway (GO:0048387)5.46774418
20DNA methylation involved in gamete generation (GO:0043046)5.42941812
21regulation of attachment of spindle microtubules to kinetochore (GO:0051988)5.39808920
22regulation of meiosis I (GO:0060631)5.36460488
23regulation of steroid hormone secretion (GO:2000831)5.32604420
24oocyte maturation (GO:0001556)5.31583771
25cell-cell recognition (GO:0009988)5.31372828
26metaphase plate congression (GO:0051310)5.22799267
27histone H2A monoubiquitination (GO:0035518)5.18334620
28peptidyl-arginine modification (GO:0018195)5.13822536
29* female gamete generation (GO:0007292)5.11607632
30regulation of meiotic cell cycle (GO:0051445)5.10193210
31positive regulation of histone H3-K4 methylation (GO:0051571)5.06958392
32positive regulation of interleukin-4 production (GO:0032753)5.05364799
33attachment of spindle microtubules to kinetochore (GO:0008608)5.03341532
34male meiosis (GO:0007140)5.00747285
35regulation of reproductive process (GO:2000241)4.98109228
36regulation of exit from mitosis (GO:0007096)4.96593116
37DNA damage induced protein phosphorylation (GO:0006975)4.95283530
38negative regulation of histone methylation (GO:0031061)4.90241960
39regulation of acrosome reaction (GO:0060046)4.85439884
40protein localization to kinetochore (GO:0034501)4.79117105
41establishment of chromosome localization (GO:0051303)4.77705004
42histone H2A ubiquitination (GO:0033522)4.77514409
43glycerophospholipid catabolic process (GO:0046475)4.73740291
44mitotic sister chromatid segregation (GO:0000070)4.70901646
45regulation of histone H3-K27 methylation (GO:0061085)4.67446671
46regulation of sister chromatid cohesion (GO:0007063)4.65239944
47protein K6-linked ubiquitination (GO:0085020)4.63940698
48negative regulation of hormone biosynthetic process (GO:0032353)4.61722472
49negative regulation of hormone metabolic process (GO:0032351)4.61722472
50multicellular organism reproduction (GO:0032504)4.57717724
51negative regulation of smooth muscle cell differentiation (GO:0051151)4.49592261
52immunoglobulin mediated immune response (GO:0016064)4.47746043
53positive regulation of calcium ion import (GO:0090280)4.40189584
54negative regulation of meiotic cell cycle (GO:0051447)4.40183988
55protein localization to chromosome, centromeric region (GO:0071459)4.39867766
56maturation of 5.8S rRNA (GO:0000460)4.39161244
57regulation of RIG-I signaling pathway (GO:0039535)4.31617363
58regulation of retinoic acid receptor signaling pathway (GO:0048385)4.28543111
59retinal cone cell development (GO:0046549)4.12850974
60phosphatidylinositol dephosphorylation (GO:0046856)4.09807598
61meiotic chromosome segregation (GO:0045132)4.09456888
62negative regulation of reproductive process (GO:2000242)4.06325737
63protein localization to chromosome (GO:0034502)4.05099654
64regulation of transforming growth factor beta2 production (GO:0032909)4.05032797
65histone H3-K4 trimethylation (GO:0080182)4.00329770
66gene silencing by RNA (GO:0031047)3.97041861
67microtubule severing (GO:0051013)3.95924144
68base-excision repair, AP site formation (GO:0006285)3.91063730
69negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.90896600
70negative regulation of DNA-templated transcription, elongation (GO:0032785)3.90896600
71regulation of spindle organization (GO:0090224)3.90438064
72interkinetic nuclear migration (GO:0022027)3.87960693
73citrulline biosynthetic process (GO:0019240)3.85533764
74phospholipid dephosphorylation (GO:0046839)3.82354907
75notochord development (GO:0030903)3.82063891
76regulation of DNA methylation (GO:0044030)3.81198941
77DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.78534675
78sister chromatid segregation (GO:0000819)3.78344875
79type B pancreatic cell development (GO:0003323)3.76428744
80regulation of mitotic spindle organization (GO:0060236)3.72802604
81DNA damage response, signal transduction resulting in transcription (GO:0042772)3.72786756
82regulation of chromatin binding (GO:0035561)3.72599073
83female gonad development (GO:0008585)3.69600932
84pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.68987411
85regulation of hypersensitivity (GO:0002883)3.68681971
86CENP-A containing nucleosome assembly (GO:0034080)3.67530785
87chromosome segregation (GO:0007059)3.65868565
88positive regulation of chromosome segregation (GO:0051984)3.65589833
89regulation of glucocorticoid metabolic process (GO:0031943)3.62843638
90DNA methylation (GO:0006306)3.62409452
91DNA alkylation (GO:0006305)3.62409452
92spindle checkpoint (GO:0031577)3.62124110
93regulation of interleukin-4 production (GO:0032673)3.61543100
94negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.61114394
95regulation of chromatin silencing (GO:0031935)3.60743479
96regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.60065299
97regulation of chromosome segregation (GO:0051983)3.55107410
98B cell mediated immunity (GO:0019724)3.54123731
99positive regulation of megakaryocyte differentiation (GO:0045654)3.53624530
100chromatin remodeling at centromere (GO:0031055)3.51161109
101oogenesis (GO:0048477)3.47254938
102histone H3-K4 methylation (GO:0051568)3.40424550
103stress granule assembly (GO:0034063)3.37559990
104N-terminal protein amino acid acetylation (GO:0006474)3.37314896
105regulation of histone H3-K4 methylation (GO:0051569)3.37288357
106DNA replication-independent nucleosome assembly (GO:0006336)3.37114065
107DNA replication-independent nucleosome organization (GO:0034724)3.37114065
108regulation of steroid hormone biosynthetic process (GO:0090030)3.36230487
109reproduction (GO:0000003)3.35893462
110monoubiquitinated protein deubiquitination (GO:0035520)3.35248519
111regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.34564769
112histone exchange (GO:0043486)3.33704744
113histone lysine demethylation (GO:0070076)3.33631473
114positive regulation of histone methylation (GO:0031062)3.31970446
115mitotic sister chromatid cohesion (GO:0007064)3.27152062
116mitotic nuclear envelope disassembly (GO:0007077)3.26741849
117regulation of cell maturation (GO:1903429)3.23117998
118mitotic spindle checkpoint (GO:0071174)3.22649587
119negative regulation of nuclear division (GO:0051784)3.22036861
120positive regulation of DNA-dependent DNA replication (GO:2000105)3.21822131
121positive regulation of mitotic sister chromatid separation (GO:1901970)3.21722618
122positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.21722618
123positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.21722618
124parturition (GO:0007567)3.21586631
125negative regulation of cell division (GO:0051782)3.20734707
126regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00433.19887370
127positive regulation of exocytosis (GO:0045921)3.19197097
128phosphatidylglycerol biosynthetic process (GO:0006655)3.16487020
129histone demethylation (GO:0016577)3.16037642
130regulation of inflammatory response to antigenic stimulus (GO:0002861)3.16031946
131snRNA transcription (GO:0009301)3.15720686
132positive regulation of Cdc42 GTPase activity (GO:0043089)3.12939005
133membrane disassembly (GO:0030397)3.12812401
134nuclear envelope disassembly (GO:0051081)3.12812401
135meiotic nuclear division (GO:0007126)3.10338380
136negative regulation of histone modification (GO:0031057)3.10173079
137positive regulation of gene expression, epigenetic (GO:0045815)3.08653380
138microtubule nucleation (GO:0007020)3.07746928
139negative regulation of chromosome segregation (GO:0051985)3.06455607
140oocyte development (GO:0048599)3.05564052
141positive regulation of humoral immune response (GO:0002922)3.04290332
142DNA methylation or demethylation (GO:0044728)3.03969816
143primitive streak formation (GO:0090009)3.03826645
144negative regulation of sister chromatid segregation (GO:0033046)3.03250271
145negative regulation of mitotic sister chromatid segregation (GO:0033048)3.03250271
146positive regulation of gastrulation (GO:2000543)3.02778487
147positive regulation of hormone biosynthetic process (GO:0046886)3.01206019
148regulation of G2/M transition of mitotic cell cycle (GO:0010389)2.95201322
149histone H3-K36 demethylation (GO:0070544)2.93966790
150gene silencing (GO:0016458)2.93737269
151histone H3-K9 demethylation (GO:0033169)2.93440912
152phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.89616786
153protein dealkylation (GO:0008214)2.87864159
154protein demethylation (GO:0006482)2.87864159
155negative regulation of organelle assembly (GO:1902116)2.84254932
156regulation of humoral immune response (GO:0002920)2.82923338
157regulation of histone methylation (GO:0031060)2.81856012
158glycine transport (GO:0015816)2.81206790
159negative regulation of gene silencing (GO:0060969)2.77402055
160negative regulation of chromatin modification (GO:1903309)2.75121490
161regulation of cell cycle G2/M phase transition (GO:1902749)2.73082278
162cell-cell junction maintenance (GO:0045217)2.72453438
163regulation of gene expression by genetic imprinting (GO:0006349)2.70524787
164DNA replication checkpoint (GO:0000076)2.66722418
165regulation of corticosteroid hormone secretion (GO:2000846)2.62559531
166neuron death (GO:0070997)2.61768833
167regulation of calcium ion import (GO:0090279)2.60529956
168negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.58451473
169synaptonemal complex assembly (GO:0007130)2.56433491
170positive regulation of acute inflammatory response (GO:0002675)2.54100703
171positive regulation of endothelial cell differentiation (GO:0045603)2.53408567
172protein kinase C signaling (GO:0070528)12.6579358
173positive regulation of calcium ion-dependent exocytosis (GO:0045956)10.4578385

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.99040130
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.29673258
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.11522159
4KAP1_22055183_ChIP-Seq_ESCs_Mouse3.87332127
5E2F7_22180533_ChIP-Seq_HELA_Human3.79024925
6AR_21909140_ChIP-Seq_LNCAP_Human3.49018990
7SMAD_19615063_ChIP-ChIP_OVARY_Human3.46959655
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.32914214
9SALL1_21062744_ChIP-ChIP_HESCs_Human3.27011854
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.94572722
11NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.57022575
12GATA1_26923725_Chip-Seq_HPCs_Mouse2.43448967
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.10214785
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.09729106
15FLI1_27457419_Chip-Seq_LIVER_Mouse1.94240498
16MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.87554822
17IGF1R_20145208_ChIP-Seq_DFB_Human1.82008795
18STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.79898302
19SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.75191650
20EZH2_22144423_ChIP-Seq_EOC_Human1.73581810
21MYC_18940864_ChIP-ChIP_HL60_Human1.73066070
22RUNX1_26923725_Chip-Seq_HPCs_Mouse1.70057116
23NOTCH1_21737748_ChIP-Seq_TLL_Human1.69929754
24AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.63431835
25MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.63358251
26RNF2_27304074_Chip-Seq_NSC_Mouse1.60464221
27LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.58766875
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56917417
29E2F1_21310950_ChIP-Seq_MCF-7_Human1.55634159
30TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.52520349
31CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51727721
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.50944508
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.50505597
34BP1_19119308_ChIP-ChIP_Hs578T_Human1.50503692
35CDX2_22108803_ChIP-Seq_LS180_Human1.42276908
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.41978953
37POU3F2_20337985_ChIP-ChIP_501MEL_Human1.39750076
38STAT1_17558387_ChIP-Seq_HELA_Human1.36808773
39FOXM1_26456572_ChIP-Seq_MCF-7_Human1.34667101
40KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.33133215
41PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.29115888
42HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.28696551
43STAT3_23295773_ChIP-Seq_U87_Human1.27941494
44RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24924473
45AUTS2_25519132_ChIP-Seq_293T-REX_Human1.23909700
46ESR1_20079471_ChIP-ChIP_T-47D_Human1.23519290
47NANOG_18555785_Chip-Seq_ESCs_Mouse1.23232381
48FUS_26573619_Chip-Seq_HEK293_Human1.23087626
49GATA3_21867929_ChIP-Seq_TH1_Mouse1.22572711
50SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.21486891
51SUZ12_27294783_Chip-Seq_NPCs_Mouse1.20399708
52SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20199511
53ELK4_26923725_Chip-Seq_MESODERM_Mouse1.19957421
54AR_21572438_ChIP-Seq_LNCaP_Human1.18682119
55NANOG_21062744_ChIP-ChIP_HESCs_Human1.18628983
56NFYA_21822215_ChIP-Seq_K562_Human1.14870513
57MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.14083333
58CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.13262282
59STAT6_21828071_ChIP-Seq_BEAS2B_Human1.13115702
60SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.11532098
61KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.11473175
62GATA1_19941827_ChIP-Seq_MEL86_Mouse1.10578033
63NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.10383085
64TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09860999
65ERG_20517297_ChIP-Seq_VCAP_Human1.09285734
66OCT4_19829295_ChIP-Seq_ESCs_Human1.08894841
67NFE2_27457419_Chip-Seq_LIVER_Mouse1.07951643
68CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06007215
69KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.05982298
70KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.05982298
71KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.05982298
72SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.05240641
73EZH2_27294783_Chip-Seq_NPCs_Mouse1.03801281
74EWS_26573619_Chip-Seq_HEK293_Human1.03400230
75TP63_19390658_ChIP-ChIP_HaCaT_Human1.02317472
76STAT3_18555785_Chip-Seq_ESCs_Mouse1.01873374
77KDM2B_26808549_Chip-Seq_REH_Human1.01868516
78CTCF_18555785_Chip-Seq_ESCs_Mouse1.00865378
79KLF4_19829295_ChIP-Seq_ESCs_Human1.00520544
80RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.99213531
81TBL1_22424771_ChIP-Seq_293T_Human0.98125280
82KLF4_18555785_Chip-Seq_ESCs_Mouse0.97701093
83TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97415007
84POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97415007
85TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.96065620
86PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95386926
87GF1B_26923725_Chip-Seq_HPCs_Mouse0.95330111
88GBX2_23144817_ChIP-Seq_PC3_Human0.94939559
89TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.94794754
90FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.94032269
91SMAD4_21741376_ChIP-Seq_EPCs_Human0.93703064
92CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.93440337
93FOXH1_21741376_ChIP-Seq_EPCs_Human0.93396667
94MYCN_18555785_ChIP-Seq_MESCs_Mouse0.93183223
95NMYC_18555785_Chip-Seq_ESCs_Mouse0.93001075
96CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.91711392
97EP300_21415370_ChIP-Seq_HL-1_Mouse0.91132408
98EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.90872511
99TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.90821077
100VDR_22108803_ChIP-Seq_LS180_Human0.90705305
101SOX2_18555785_Chip-Seq_ESCs_Mouse0.90277938
102PRDM14_20953172_ChIP-Seq_ESCs_Human0.89870186
103TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.89481357
104E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.89154152
105HNFA_21074721_ChIP-Seq_CACO-2_Human0.88825787
106ESRRB_18555785_Chip-Seq_ESCs_Mouse0.88380703
107GF1_26923725_Chip-Seq_HPCs_Mouse0.87702283
108ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.87240189
109LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86574994
110MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.86025253
111GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.85890608
112PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.85142591
113CTBP2_25329375_ChIP-Seq_LNCAP_Human0.84320664
114E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.84283063
115TCF4_23295773_ChIP-Seq_U87_Human0.83551858
116CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.83199772
117PKCTHETA_26484144_Chip-Seq_BREAST_Human0.82464777
118CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.81752217
119NANOG_20526341_ChIP-Seq_ESCs_Human0.81309769
120SMAD3_21741376_ChIP-Seq_EPCs_Human0.79329728
121BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.77472204
122RXR_22108803_ChIP-Seq_LS180_Human0.74205178
123DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.73273040
124TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.70290580
125TOP2B_26459242_ChIP-Seq_MCF-7_Human0.69735771
126AR_25329375_ChIP-Seq_VCAP_Human0.67606872
127SMAD3_21741376_ChIP-Seq_ESCs_Human0.66755924
128SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.66387101
129P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.65657901
130DROSHA_22980978_ChIP-Seq_HELA_Human0.64540664
131SMAD4_21799915_ChIP-Seq_A2780_Human0.63208896
132FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.62066540
133UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.61545434
134KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.60630532
135ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.59313834
136ZNF217_24962896_ChIP-Seq_MCF-7_Human0.58543472
137SMAD4_21741376_ChIP-Seq_ESCs_Human0.58357732
138* RUNX2_22187159_ChIP-Seq_PCA_Human0.58036249
139AR_19668381_ChIP-Seq_PC3_Human0.57659281
140SOX2_21211035_ChIP-Seq_LN229_Gbm0.57064110
141SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.56936202
142SMRT_27268052_Chip-Seq_Bcells_Human0.56687047
143IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.56327348
144CBP_20019798_ChIP-Seq_JUKART_Human0.56327348
145STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.55798818
146CBP_21632823_ChIP-Seq_H3396_Human0.54409925
147SRY_22984422_ChIP-ChIP_TESTIS_Rat0.53882200
148SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.53696159
149EZH2_27304074_Chip-Seq_ESCs_Mouse0.53474274
150CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.52298973
151CTNNB1_20460455_ChIP-Seq_HCT116_Human0.51822234
152E2F1_17053090_ChIP-ChIP_MCF-7_Human0.50699190
153STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.50150012
154AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.49894848
155PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.49171588
156FOXO3_23340844_ChIP-Seq_DLD1_Human0.47958348
157ESET_19884257_ChIP-Seq_ESCs_Mouse0.47834645
158GATA3_21878914_ChIP-Seq_MCF-7_Human0.47496781
159SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.47195986
160OCT4_20526341_ChIP-Seq_ESCs_Human0.46716356
161SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.46679877
162SALL4_22934838_ChIP-ChIP_CD34+_Human0.46653228
163WT1_25993318_ChIP-Seq_PODOCYTE_Human0.46643069
164TCF4_22108803_ChIP-Seq_LS180_Human0.46420093
165REST_21632747_ChIP-Seq_MESCs_Mouse0.46167032
166PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.44520175

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect6.55186383
2MP0003646_muscle_fatigue5.78181195
3MP0005451_abnormal_body_composition5.62889206
4MP0002102_abnormal_ear_morphology4.46438286
5MP0008877_abnormal_DNA_methylation3.94703428
6MP0003693_abnormal_embryo_hatching3.77127226
7MP0010094_abnormal_chromosome_stability3.29272745
8MP0008789_abnormal_olfactory_epithelium3.19630689
9MP0002139_abnormal_hepatobiliary_system3.19537757
10MP0002653_abnormal_ependyma_morphology3.02386242
11MP0005395_other_phenotype3.00340500
12MP0005499_abnormal_olfactory_system2.89402771
13MP0005394_taste/olfaction_phenotype2.89402771
14* MP0003699_abnormal_female_reproductive2.81504427
15* MP0001119_abnormal_female_reproductive2.75749580
16MP0003077_abnormal_cell_cycle2.65541000
17MP0003111_abnormal_nucleus_morphology2.62683555
18MP0003890_abnormal_embryonic-extraembry2.60404831
19MP0002138_abnormal_hepatobiliary_system2.50030232
20MP0008057_abnormal_DNA_replication2.43741863
21MP0004957_abnormal_blastocyst_morpholog2.33254776
22MP0000579_abnormal_nail_morphology2.31075226
23* MP0001929_abnormal_gametogenesis2.26705102
24MP0005408_hypopigmentation2.22328770
25MP0002249_abnormal_larynx_morphology2.22012869
26* MP0000653_abnormal_sex_gland2.15962424
27MP0003123_paternal_imprinting2.05193858
28MP0003787_abnormal_imprinting2.04871571
29MP0002210_abnormal_sex_determination2.04708290
30MP0006292_abnormal_olfactory_placode1.88300918
31MP0005646_abnormal_pituitary_gland1.84887385
32MP0000566_synostosis1.83737803
33MP0010030_abnormal_orbit_morphology1.82171618
34MP0003121_genomic_imprinting1.81442741
35MP0003937_abnormal_limbs/digits/tail_de1.77775919
36MP0010307_abnormal_tumor_latency1.73712556
37MP0009840_abnormal_foam_cell1.71846207
38MP0003315_abnormal_perineum_morphology1.63175773
39MP0002234_abnormal_pharynx_morphology1.62791238
40MP0008932_abnormal_embryonic_tissue1.62297895
41MP0003879_abnormal_hair_cell1.55040747
42* MP0002161_abnormal_fertility/fecundity1.50386248
43MP0001529_abnormal_vocalization1.47125658
44MP0005410_abnormal_fertilization1.44223692
45MP0001905_abnormal_dopamine_level1.42914442
46MP0003183_abnormal_peptide_metabolism1.41537387
47MP0001145_abnormal_male_reproductive1.40161237
48MP0000462_abnormal_digestive_system1.35983353
49MP0002295_abnormal_pulmonary_circulatio1.32719101
50MP0001915_intracranial_hemorrhage1.28528568
51MP0004185_abnormal_adipocyte_glucose1.27331562
52MP0010368_abnormal_lymphatic_system1.27154469
53MP0002085_abnormal_embryonic_tissue1.23636892
54MP0005310_abnormal_salivary_gland1.21977052
55MP0010678_abnormal_skin_adnexa1.20667596
56MP0004264_abnormal_extraembryonic_tissu1.20034280
57MP0003252_abnormal_bile_duct1.18833266
58MP0005409_darkened_coat_color1.18204953
59MP0000350_abnormal_cell_proliferation1.17623370
60MP0001730_embryonic_growth_arrest1.17162185
61MP0000639_abnormal_adrenal_gland1.15113098
62MP0003959_abnormal_lean_body1.14765764
63MP0001919_abnormal_reproductive_system1.13744455
64MP0005187_abnormal_penis_morphology1.11077097
65MP0001666_abnormal_nutrient_absorption1.08581175
66MP0001664_abnormal_digestion1.07455875
67MP0001697_abnormal_embryo_size1.05248619
68MP0008260_abnormal_autophagy1.04497298
69MP0010234_abnormal_vibrissa_follicle1.02123560
70MP0003950_abnormal_plasma_membrane1.02003687
71MP0002084_abnormal_developmental_patter0.98944768
72MP0000383_abnormal_hair_follicle0.98787296
73MP0010386_abnormal_urinary_bladder0.97951716
74MP0006072_abnormal_retinal_apoptosis0.96655950
75MP0000733_abnormal_muscle_development0.94348466
76MP0008007_abnormal_cellular_replicative0.93343627
77MP0001293_anophthalmia0.91033694
78MP0002019_abnormal_tumor_incidence0.90990434
79MP0002089_abnormal_postnatal_growth/wei0.90676458
80MP0000762_abnormal_tongue_morphology0.90481015
81MP0005389_reproductive_system_phenotype0.89682074
82MP0004510_myositis0.89634732
83MP0001672_abnormal_embryogenesis/_devel0.88815560
84MP0005380_embryogenesis_phenotype0.88815560
85MP0002233_abnormal_nose_morphology0.88153743
86MP0003119_abnormal_digestive_system0.87479864
87MP0003868_abnormal_feces_composition0.87250874
88MP0003329_amyloid_beta_deposits0.86610339
89MP0002877_abnormal_melanocyte_morpholog0.86219649
90MP0001984_abnormal_olfaction0.86114361
91MP0005076_abnormal_cell_differentiation0.85371159
92MP0009384_cardiac_valve_regurgitation0.82650187
93MP0001346_abnormal_lacrimal_gland0.82468342
94MP0003453_abnormal_keratinocyte_physiol0.82215097
95MP0002160_abnormal_reproductive_system0.82118346
96MP0000678_abnormal_parathyroid_gland0.80387265
97MP0002177_abnormal_outer_ear0.80311312
98MP0003698_abnormal_male_reproductive0.80274445
99MP0003755_abnormal_palate_morphology0.78842134
100MP0002932_abnormal_joint_morphology0.78395005
101MP0003656_abnormal_erythrocyte_physiolo0.76929885
102MP0004145_abnormal_muscle_electrophysio0.75825924
103MP0000427_abnormal_hair_cycle0.73717196
104MP0002282_abnormal_trachea_morphology0.72030150
105MP0001851_eye_inflammation0.71021564
106MP0005360_urolithiasis0.70738646
107MP0002272_abnormal_nervous_system0.69471132
108MP0005085_abnormal_gallbladder_physiolo0.68888217
109MP0005257_abnormal_intraocular_pressure0.68329254
110MP0000490_abnormal_crypts_of0.67291919
111MP0005621_abnormal_cell_physiology0.65753859
112MP0000613_abnormal_salivary_gland0.64954824
113MP0002098_abnormal_vibrissa_morphology0.63819134
114MP0004859_abnormal_synaptic_plasticity0.62772894
115MP0009697_abnormal_copulation0.62681483
116MP0004270_analgesia0.61868251
117MP0009250_abnormal_appendicular_skeleto0.60979694
118MP0008058_abnormal_DNA_repair0.59980747
119MP0005647_abnormal_sex_gland0.59971155
120MP0002928_abnormal_bile_duct0.59919383
121MP0001324_abnormal_eye_pigmentation0.57379938
122MP0005197_abnormal_uvea_morphology0.57210088
123MP0005397_hematopoietic_system_phenotyp0.54674869
124MP0001545_abnormal_hematopoietic_system0.54674869
125MP0002116_abnormal_craniofacial_bone0.54671723
126MP0000631_abnormal_neuroendocrine_gland0.54470249
127MP0002168_other_aberrant_phenotype0.54085727
128MP0003763_abnormal_thymus_physiology0.52959165
129MP0003941_abnormal_skin_development0.51930106
130MP0006138_congestive_heart_failure0.51668175
131MP0004782_abnormal_surfactant_physiolog0.51610525
132MP0002080_prenatal_lethality0.51462726
133MP0001849_ear_inflammation0.51033175
134MP0003567_abnormal_fetal_cardiomyocyte0.51010123
135MP0003861_abnormal_nervous_system0.50604936
136MP0002109_abnormal_limb_morphology0.48341318
137MP0003984_embryonic_growth_retardation0.47044020
138MP0002837_dystrophic_cardiac_calcinosis0.47007042
139MP0005384_cellular_phenotype0.46651361
140MP0005551_abnormal_eye_electrophysiolog0.46455388
141MP0000377_abnormal_hair_follicle0.46171727
142MP0004233_abnormal_muscle_weight0.46123339
143MP0003935_abnormal_craniofacial_develop0.45183748
144MP0000470_abnormal_stomach_morphology0.44482701
145MP0002108_abnormal_muscle_morphology0.44279117
146MP0002088_abnormal_embryonic_growth/wei0.43481542
147MP0001502_abnormal_circadian_rhythm0.43408157
148MP0003136_yellow_coat_color0.42566996
149MP0000604_amyloidosis0.37511930
150MP0004142_abnormal_muscle_tone0.36750597
151MP0001944_abnormal_pancreas_morphology0.36387081
152MP0001879_abnormal_lymphatic_vessel0.36235878
153MP0001986_abnormal_taste_sensitivity0.36168808
154MP0002735_abnormal_chemical_nociception0.35119544

Predicted human phenotypes

RankGene SetZ-score
1Male infertility (HP:0003251)8.11655566
2Impulsivity (HP:0100710)5.83810938
3Aplasia/Hypoplasia of the macula (HP:0008059)5.23630431
4Papillary thyroid carcinoma (HP:0002895)5.04286547
5Premature ovarian failure (HP:0008209)4.87236296
6Aplasia/Hypoplasia affecting the retina (HP:0008061)4.83759773
7Chromsome breakage (HP:0040012)4.72386228
8Abnormality of abdominal situs (HP:0011620)4.70807360
9Abdominal situs inversus (HP:0003363)4.70807360
10Cortical dysplasia (HP:0002539)4.69652691
11Flat capital femoral epiphysis (HP:0003370)4.45007596
12Birth length less than 3rd percentile (HP:0003561)4.35496129
13Chromosomal breakage induced by crosslinking agents (HP:0003221)4.26994944
14Infertility (HP:0000789)4.22060289
15Shawl scrotum (HP:0000049)4.21917250
16Adrenal hypoplasia (HP:0000835)4.19673634
17Breast hypoplasia (HP:0003187)4.16075778
18Osteomalacia (HP:0002749)4.11522878
19Abnormality of the labia minora (HP:0012880)4.10737606
20Apathy (HP:0000741)3.96636484
21Patellar aplasia (HP:0006443)3.95866470
22Facial hemangioma (HP:0000329)3.86845482
23Abnormal gallbladder physiology (HP:0012438)3.71404906
24Cholecystitis (HP:0001082)3.71404906
25Diminished motivation (HP:0000745)3.70404187
26Aplasia/Hypoplasia of the patella (HP:0006498)3.63574141
27Deep venous thrombosis (HP:0002625)3.53779678
28Arterial tortuosity (HP:0005116)3.51401903
29Abnormality of the anterior chamber (HP:0000593)3.42244627
30Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.36861467
31Abnormality of chromosome segregation (HP:0002916)3.34800034
32Hypophosphatemic rickets (HP:0004912)3.33850003
33Septo-optic dysplasia (HP:0100842)3.31171118
34Aplasia/Hypoplasia of the breasts (HP:0010311)3.16626090
35Breast aplasia (HP:0100783)3.15426890
36Aplasia of the musculature (HP:0100854)3.07169906
37Obstructive sleep apnea (HP:0002870)3.05424936
38Vascular tortuosity (HP:0004948)3.02718261
39Capillary hemangiomas (HP:0005306)3.00691006
40Azoospermia (HP:0000027)2.99061364
41Spondylolisthesis (HP:0003302)2.87699828
42Abnormality of the fingertips (HP:0001211)2.82503442
43Acute myeloid leukemia (HP:0004808)2.79389966
44Insulin-resistant diabetes mellitus (HP:0000831)2.76632795
45Sandal gap (HP:0001852)2.76441891
46Abnormality of the fovea (HP:0000493)2.74238321
47Oligodactyly (hands) (HP:0001180)2.71741692
48Gonadotropin excess (HP:0000837)2.71144617
49Hypokinesia (HP:0002375)2.70765567
50Truncal obesity (HP:0001956)2.69986912
51Abnormality of chromosome stability (HP:0003220)2.68287705
52Myokymia (HP:0002411)2.64712698
53Supernumerary spleens (HP:0009799)2.62174626
54Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.62099289
55Cone-rod dystrophy (HP:0000548)2.61995055
56Aplasia/Hypoplasia of the fovea (HP:0008060)2.61550170
57Hypoplasia of the fovea (HP:0007750)2.61550170
58Thyroid carcinoma (HP:0002890)2.58765232
59Abnormality of lateral ventricle (HP:0030047)2.58016142
60Supranuclear gaze palsy (HP:0000605)2.56272235
61Chronic bronchitis (HP:0004469)2.55200639
62Posterior embryotoxon (HP:0000627)2.52307199
63Aplasia/Hypoplasia of the sternum (HP:0006714)2.51213683
64Urethral obstruction (HP:0000796)2.49124111
65Abnormality of the proximal phalanges of the hand (HP:0009834)2.49084597
66Carpal bone hypoplasia (HP:0001498)2.48831444
67Lip pit (HP:0100267)2.48335239
68Anhidrosis (HP:0000970)2.46511175
69Rhabdomyosarcoma (HP:0002859)2.44867468
70Aplasia/Hypoplasia of the uvula (HP:0010293)2.44593834
71Overlapping toe (HP:0001845)2.41332953
72Loss of speech (HP:0002371)2.39862379
73Abnormality of the line of Schwalbe (HP:0008048)2.39852456
74Anterior segment dysgenesis (HP:0007700)2.38904283
75Neurofibrillary tangles (HP:0002185)2.36925628
76Spinal cord compression (HP:0002176)2.34719497
77Absent septum pellucidum (HP:0001331)2.33667568
78Duodenal stenosis (HP:0100867)2.33643327
79Small intestinal stenosis (HP:0012848)2.33643327
80Oligodactyly (HP:0012165)2.33275149
81Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.31769057
82Nonprogressive disorder (HP:0003680)2.30941067
83Metaphyseal irregularity (HP:0003025)2.30594157
84Abnormality of the preputium (HP:0100587)2.29617719
85Bundle branch block (HP:0011710)2.28477022
86Lower limb hyperreflexia (HP:0002395)2.25415012
87Abnormality of the epiphysis of the femoral head (HP:0010574)2.25280292
88Wrist flexion contracture (HP:0001239)2.25130637
89Fetal akinesia sequence (HP:0001989)2.24988323
90Abnormality of placental membranes (HP:0011409)2.23928859
91Amniotic constriction ring (HP:0009775)2.23928859
92Cystic hygroma (HP:0000476)2.23687589
93Aplasia/Hypoplasia involving the musculature (HP:0001460)2.23486770
94Absent radius (HP:0003974)2.19227362
95Meckel diverticulum (HP:0002245)2.18756146
96Abnormal spermatogenesis (HP:0008669)2.17970149
97Fibular aplasia (HP:0002990)2.15683415
98Aplasia involving forearm bones (HP:0009822)2.13259755
99Absent forearm bone (HP:0003953)2.13259755
100Sloping forehead (HP:0000340)2.12175293
101Dysmetric saccades (HP:0000641)2.10917854
102Fair hair (HP:0002286)2.09878065
103Subcapsular cataract (HP:0000523)2.07785345
104Sparse lateral eyebrow (HP:0005338)2.07382206
105Skin pits (HP:0100276)2.07219809
106Increased circulating renin level (HP:0000848)2.07156353
107Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.07053228
108Progressive sensorineural hearing impairment (HP:0000408)2.07025069
109Abnormality of the femoral head (HP:0003368)2.07023203
110Midline defect of the nose (HP:0004122)2.05248400
111Type 2 muscle fiber atrophy (HP:0003554)2.04191745
112Combined immunodeficiency (HP:0005387)2.04162408
113Abnormality of the phalanges of the hallux (HP:0010057)2.03930712
114Abnormality of femoral epiphyses (HP:0006499)2.02660752
115Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.02660752
116Tubulointerstitial nephritis (HP:0001970)2.02151465
117Abnormality of the ileum (HP:0001549)2.01867975
118Dysdiadochokinesis (HP:0002075)2.01550582
119Ectopic kidney (HP:0000086)2.00829317
120Abnormality of the salivary glands (HP:0010286)2.00379436
121Camptodactyly of toe (HP:0001836)2.00212266
122Myelodysplasia (HP:0002863)1.99928032
123Non-midline cleft lip (HP:0100335)1.98150820
124Hyperglycemia (HP:0003074)1.97780665
125Hydroureter (HP:0000072)1.96599175
126Short thumb (HP:0009778)1.95672652
127Muscle fiber atrophy (HP:0100295)1.95271355
128Intrahepatic cholestasis (HP:0001406)1.94732498
129Nephroblastoma (Wilms tumor) (HP:0002667)1.94696336
130Abnormality of the septum pellucidum (HP:0007375)1.93419985
131Leiomyosarcoma (HP:0100243)1.92129515
132Uterine leiomyosarcoma (HP:0002891)1.92129515
133Congenital sensorineural hearing impairment (HP:0008527)1.92061017
134Rib fusion (HP:0000902)1.92040750
135Shallow orbits (HP:0000586)1.90124827
136Aplastic anemia (HP:0001915)1.89625095
137Enlarged penis (HP:0000040)1.89572365
138Hypoplastic iliac wings (HP:0002866)1.88805793
139Malnutrition (HP:0004395)1.88621626
140Cafe-au-lait spot (HP:0000957)1.86493540
141Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.85943002
142Clubbing of toes (HP:0100760)1.85145815
143Aplasia involving bones of the upper limbs (HP:0009823)1.84374145
144Aplasia of the phalanges of the hand (HP:0009802)1.84374145
145Aplasia involving bones of the extremities (HP:0009825)1.84374145
146Abnormality of cochlea (HP:0000375)1.83757417
147Abnormal lung lobation (HP:0002101)1.82199768
148Flat acetabular roof (HP:0003180)1.81702334
149Embryonal renal neoplasm (HP:0011794)1.79820424
150Abnormality of small intestinal villus morphology (HP:0011472)1.79288517
151Villous atrophy (HP:0011473)1.79288517
152Hyperalaninemia (HP:0003348)1.77123390
153Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.77123390
154Abnormality of alanine metabolism (HP:0010916)1.77123390
155Median cleft lip (HP:0000161)1.77115318
156Abnormality of the duodenum (HP:0002246)1.76533051
157Abnormality of monocarboxylic acid metabolism (HP:0010996)1.75336323
158Striae distensae (HP:0001065)1.74433578
159Abnormal biliary tract physiology (HP:0012439)1.73441044
160Bile duct proliferation (HP:0001408)1.73441044
161Maternal diabetes (HP:0009800)1.72540556
162Chronic hepatic failure (HP:0100626)1.72478761
163Hip contracture (HP:0003273)1.70999022
164Renovascular hypertension (HP:0100817)1.68511632
165Decreased circulating renin level (HP:0003351)1.67779261
166Heterotopia (HP:0002282)1.66803982
167Limb hypertonia (HP:0002509)1.66323145
168Prolonged neonatal jaundice (HP:0006579)1.65951401
169Esotropia (HP:0000565)1.65782495
170Hyperactive renin-angiotensin system (HP:0000841)1.65585629
171Hand muscle atrophy (HP:0009130)1.64827069

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK127.63221302
2MAP3K63.99889634
3TAOK33.65255958
4EEF2K3.59463292
5LATS13.54484573
6KSR23.53211254
7ERBB43.46202424
8CAMK1D3.39789834
9TTK3.37105805
10MUSK3.33155202
11PLK43.29700721
12BRAF3.29497244
13LATS23.22555190
14MOS3.16325758
15MAP3K93.03023769
16MAP3K132.60231521
17MET2.59032629
18NEK62.49543526
19STK38L2.48216680
20CAMK1G2.43319325
21MAPKAPK32.37702055
22BMPR22.35398681
23TAOK12.30590603
24ARAF2.26761951
25RAF12.22619716
26BRD42.14273176
27CDC71.84488249
28CDK81.80319296
29TRIM281.67071854
30MELK1.65942944
31STK101.65606359
32WNK11.49498289
33PAK61.48529778
34KSR11.47766336
35PRKD31.47373599
36STK31.47110366
37CHEK21.46225270
38MAPKAPK51.45919657
39ERN11.44912486
40TGFBR11.35771868
41CDK91.32174534
42NEK21.29267254
43MAPK131.25836338
44TNIK1.24812871
45PTK21.24741874
46MTOR1.18448314
47PLK11.17521864
48PRKCI1.15217808
49MAP3K41.13856357
50MAP3K81.06280563
51DYRK21.03293321
52MST40.94724923
53TRPM70.92371925
54PRKD20.88587356
55ZAP700.88388468
56MAP2K70.81306280
57CDC42BPA0.78338997
58RPS6KB20.77735853
59DMPK0.73542713
60RET0.73381253
61CAMK40.71843377
62NME10.71254647
63PRKAA20.70209538
64ABL20.69819549
65ICK0.69779226
66ACVR1B0.69416406
67STK380.68128978
68AURKA0.65099610
69AURKB0.64464249
70CSNK1G10.62646762
71PRKCZ0.61881294
72MARK20.61788920
73TYRO30.61250658
74PRKAA10.60391982
75NLK0.59225983
76PIM10.57659779
77MARK30.57097946
78MAP3K70.56776881
79MAP2K40.54342314
80MAPK100.53824230
81STK240.51372703
82BUB10.50545099
83PLK30.48999446
84NEK90.48061126
85MAPK110.45865264
86MAP3K50.45581006
87CSNK1G20.45468420
88ZAK0.45417910
89GSK3B0.45040974
90CDK50.44973134
91CSNK1G30.43685813
92CAMK10.41593760
93TIE10.40591857
94CLK10.40451674
95TNK20.38628223
96MAP3K10.38357936
97NTRK20.38260269
98FLT30.38059702
99ATM0.36454511
100CHEK10.36261201
101NTRK30.35389441
102EIF2AK30.33995139
103EPHA30.32527251
104STK390.32204658
105SGK20.31715811
106PINK10.31215126
107CSNK1E0.31087703
108RPS6KB10.30437915
109NUAK10.30224957
110MAPK140.29120375
111ATR0.28240567
112TAOK20.28006617
113CHUK0.27062390
114CSNK1A1L0.26992175
115TLK10.26732490
116TESK20.26636719
117MAP2K10.26564688
118CAMK2A0.25498360
119PRKG10.25434273
120PDK10.24929889
121ABL10.24830415
122CDK30.24475188
123BMPR1B0.24356188
124BRSK10.22381100
125CDK10.22341804
126SGK2230.21897334
127SGK4940.21897334
128AKT20.21871408
129EIF2AK10.21121534
130CDK40.20141512
131CDK70.19920272
132TGFBR20.19266584
133PLK20.18837048
134PRKACA0.18501282
135VRK10.17160333
136CDK20.16442583
137HIPK20.14997618
138JAK30.14955500
139PAK10.14634298
140EPHA40.13878746
141FGR0.13191316
142CSNK1D0.13055723
143JAK20.10151183
144AKT10.09471691
145ROCK10.07922204
146NTRK10.07563341
147CDK150.07305416
148RPS6KA40.07191527
149MAPK10.06249105

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041104.14969626
2RNA degradation_Homo sapiens_hsa030183.86918044
3Pathogenic Escherichia coli infection_Homo sapiens_hsa051303.63408266
4Vitamin B6 metabolism_Homo sapiens_hsa007503.31723714
5Basal transcription factors_Homo sapiens_hsa030223.19485747
6Circadian rhythm_Homo sapiens_hsa047103.12108935
7* Ovarian steroidogenesis_Homo sapiens_hsa049132.96181846
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.68974364
9Linoleic acid metabolism_Homo sapiens_hsa005912.62094816
10Pancreatic cancer_Homo sapiens_hsa052122.47510337
11Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.41782472
12Oocyte meiosis_Homo sapiens_hsa041142.40547694
13Ether lipid metabolism_Homo sapiens_hsa005652.36101920
14Homologous recombination_Homo sapiens_hsa034402.29817604
15Fanconi anemia pathway_Homo sapiens_hsa034602.16191459
16GnRH signaling pathway_Homo sapiens_hsa049121.91886414
17TGF-beta signaling pathway_Homo sapiens_hsa043501.89933444
18Dorso-ventral axis formation_Homo sapiens_hsa043201.83507259
19p53 signaling pathway_Homo sapiens_hsa041151.79926717
20Base excision repair_Homo sapiens_hsa034101.71697748
21Non-homologous end-joining_Homo sapiens_hsa034501.62813906
22RNA transport_Homo sapiens_hsa030131.52464141
23Prolactin signaling pathway_Homo sapiens_hsa049171.52140950
24Colorectal cancer_Homo sapiens_hsa052101.50462209
25Choline metabolism in cancer_Homo sapiens_hsa052311.49995415
26Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.48877343
27MicroRNAs in cancer_Homo sapiens_hsa052061.48293597
28Caffeine metabolism_Homo sapiens_hsa002321.45867215
29RNA polymerase_Homo sapiens_hsa030201.34201963
30VEGF signaling pathway_Homo sapiens_hsa043701.32346127
31ABC transporters_Homo sapiens_hsa020101.25580663
32DNA replication_Homo sapiens_hsa030301.20833889
33Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.19909864
34Nucleotide excision repair_Homo sapiens_hsa034201.18766287
35Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.17572617
36Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.16373213
37Renal cell carcinoma_Homo sapiens_hsa052111.16182029
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.12512214
39Long-term depression_Homo sapiens_hsa047301.12354810
40Mismatch repair_Homo sapiens_hsa034301.11894289
41Glycerophospholipid metabolism_Homo sapiens_hsa005641.10716301
42GABAergic synapse_Homo sapiens_hsa047271.09845405
43Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.06010700
44Olfactory transduction_Homo sapiens_hsa047401.03475585
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.94954791
46Aldosterone synthesis and secretion_Homo sapiens_hsa049250.93550658
47Hippo signaling pathway_Homo sapiens_hsa043900.92349505
48Endometrial cancer_Homo sapiens_hsa052130.91096603
49Bile secretion_Homo sapiens_hsa049760.90055558
50FoxO signaling pathway_Homo sapiens_hsa040680.90048938
51mRNA surveillance pathway_Homo sapiens_hsa030150.90024547
52Thyroid cancer_Homo sapiens_hsa052160.89655226
53Adherens junction_Homo sapiens_hsa045200.88753776
54Phototransduction_Homo sapiens_hsa047440.86929910
55mTOR signaling pathway_Homo sapiens_hsa041500.85258123
56Ras signaling pathway_Homo sapiens_hsa040140.83641446
57Other glycan degradation_Homo sapiens_hsa005110.80487091
58Phospholipase D signaling pathway_Homo sapiens_hsa040720.79478033
59Bladder cancer_Homo sapiens_hsa052190.75868157
60Non-small cell lung cancer_Homo sapiens_hsa052230.74953693
61Phagosome_Homo sapiens_hsa041450.74667514
62Notch signaling pathway_Homo sapiens_hsa043300.73802629
63Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.72345943
64Chronic myeloid leukemia_Homo sapiens_hsa052200.71945944
65Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.71328271
66HIF-1 signaling pathway_Homo sapiens_hsa040660.70439689
67Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.68539368
68Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.68409764
69Morphine addiction_Homo sapiens_hsa050320.65774358
70Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.64756223
71Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64572816
72Arachidonic acid metabolism_Homo sapiens_hsa005900.64075953
73Small cell lung cancer_Homo sapiens_hsa052220.63416353
74Inositol phosphate metabolism_Homo sapiens_hsa005620.62362494
75Nicotine addiction_Homo sapiens_hsa050330.62064884
76Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57725565
77Estrogen signaling pathway_Homo sapiens_hsa049150.57577824
78Vitamin digestion and absorption_Homo sapiens_hsa049770.55839246
79Hepatitis B_Homo sapiens_hsa051610.54736362
80Serotonergic synapse_Homo sapiens_hsa047260.52796182
81Purine metabolism_Homo sapiens_hsa002300.52298263
82ErbB signaling pathway_Homo sapiens_hsa040120.50677310
83Folate biosynthesis_Homo sapiens_hsa007900.49213453
84MAPK signaling pathway_Homo sapiens_hsa040100.49201905
85Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46980635
86Taste transduction_Homo sapiens_hsa047420.46120711
87HTLV-I infection_Homo sapiens_hsa051660.45817332
88Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.45588309
89Pyrimidine metabolism_Homo sapiens_hsa002400.45492143
90Glioma_Homo sapiens_hsa052140.44623517
91Influenza A_Homo sapiens_hsa051640.44478924
92Synaptic vesicle cycle_Homo sapiens_hsa047210.42735337
93Prostate cancer_Homo sapiens_hsa052150.42313126
94Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.42100110
95Melanogenesis_Homo sapiens_hsa049160.41303965
96Long-term potentiation_Homo sapiens_hsa047200.40855579
97Glutamatergic synapse_Homo sapiens_hsa047240.40474540
98Insulin signaling pathway_Homo sapiens_hsa049100.40034054
99Shigellosis_Homo sapiens_hsa051310.38393102
100Melanoma_Homo sapiens_hsa052180.37856904
101Amoebiasis_Homo sapiens_hsa051460.37299737
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.36586556
103Vascular smooth muscle contraction_Homo sapiens_hsa042700.35249656
104Huntingtons disease_Homo sapiens_hsa050160.33669834
105Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33271436
106Lysine degradation_Homo sapiens_hsa003100.33103575
107Phosphatidylinositol signaling system_Homo sapiens_hsa040700.32643276
108Neurotrophin signaling pathway_Homo sapiens_hsa047220.32369312
109Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32236560
110Protein digestion and absorption_Homo sapiens_hsa049740.32076454
111Regulation of actin cytoskeleton_Homo sapiens_hsa048100.30283297
112Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.29565100
113Arginine and proline metabolism_Homo sapiens_hsa003300.27894944
114PI3K-Akt signaling pathway_Homo sapiens_hsa041510.27787982
115Sphingolipid metabolism_Homo sapiens_hsa006000.27249453
116Oxytocin signaling pathway_Homo sapiens_hsa049210.26365663
117cAMP signaling pathway_Homo sapiens_hsa040240.25829467
118Cholinergic synapse_Homo sapiens_hsa047250.25126489
119Wnt signaling pathway_Homo sapiens_hsa043100.24173039
120Pathways in cancer_Homo sapiens_hsa052000.23998624
121Circadian entrainment_Homo sapiens_hsa047130.23810570
122Arginine biosynthesis_Homo sapiens_hsa002200.23490907
123Hedgehog signaling pathway_Homo sapiens_hsa043400.23113470
124Herpes simplex infection_Homo sapiens_hsa051680.21946833
125Endocytosis_Homo sapiens_hsa041440.21246134
126TNF signaling pathway_Homo sapiens_hsa046680.20027322
127SNARE interactions in vesicular transport_Homo sapiens_hsa041300.20019388
128Regulation of autophagy_Homo sapiens_hsa041400.19882871
129Gap junction_Homo sapiens_hsa045400.18065817
130Glycosaminoglycan degradation_Homo sapiens_hsa005310.16750752
131Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.14670789
132Rap1 signaling pathway_Homo sapiens_hsa040150.14565181
133Jak-STAT signaling pathway_Homo sapiens_hsa046300.13583811
134cGMP-PKG signaling pathway_Homo sapiens_hsa040220.13560342
135AMPK signaling pathway_Homo sapiens_hsa041520.13514163
136Tight junction_Homo sapiens_hsa045300.13396956
137Platelet activation_Homo sapiens_hsa046110.12677514

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