BMP10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which binds to the activin receptor-like kinase 1 (ALK1) and plays important roles in cardiovascular development including cardiomyocyte proliferation and regulation of heart size, closure of the ductus arteriosus, angiogenesis and ventricular trabeculation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cGMP biosynthetic process (GO:0006182)9.07993510
2cardiac myofibril assembly (GO:0055003)7.92111284
3cardiac chamber formation (GO:0003207)7.31290942
4positive regulation of urine volume (GO:0035810)6.97804678
5* sarcomere organization (GO:0045214)6.65208034
6negative regulation of potassium ion transmembrane transporter activity (GO:1901017)6.54732572
7negative regulation of cytosolic calcium ion concentration (GO:0051481)6.53762975
8cardiac ventricle formation (GO:0003211)6.49920170
9myofibril assembly (GO:0030239)6.49489128
10potassium ion export (GO:0071435)6.33519671
11atrioventricular valve morphogenesis (GO:0003181)6.33070857
12tricarboxylic acid cycle (GO:0006099)6.13196414
13negative regulation of potassium ion transmembrane transport (GO:1901380)6.03051027
14atrial septum morphogenesis (GO:0060413)5.97225873
15cGMP metabolic process (GO:0046068)5.96469719
16positive regulation of renal sodium excretion (GO:0035815)5.92349406
17cardiac muscle contraction (GO:0060048)5.81762637
18regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)5.78049874
19regulation of relaxation of muscle (GO:1901077)5.75532057
20* cardiac muscle hypertrophy (GO:0003300)5.75249416
21cell migration involved in heart development (GO:0060973)5.62668525
22regulation of urine volume (GO:0035809)5.55657996
23atrial cardiac muscle cell action potential (GO:0086014)5.47798069
24regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO5.43449643
25actin-myosin filament sliding (GO:0033275)5.40349271
26muscle filament sliding (GO:0030049)5.40349271
27* striated muscle hypertrophy (GO:0014897)5.39188000
28* cardiac muscle cell development (GO:0055013)5.26430153
29pericardium development (GO:0060039)5.22985160
30* cardiac muscle tissue morphogenesis (GO:0055008)5.11504281
31bundle of His cell to Purkinje myocyte communication (GO:0086069)5.10300376
32carnitine shuttle (GO:0006853)5.08966596
33positive regulation of action potential (GO:0045760)5.00123942
34cyclic purine nucleotide metabolic process (GO:0052652)4.95827094
35* ventricular cardiac muscle tissue morphogenesis (GO:0055010)4.94624429
36regulation of actin filament-based movement (GO:1903115)4.92231948
37* cardiac cell development (GO:0055006)4.92079794
38fatty acid transmembrane transport (GO:1902001)4.91297000
39membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.90914959
40regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.87912537
41* muscle hypertrophy (GO:0014896)4.80749895
42cyclic nucleotide biosynthetic process (GO:0009190)4.77044990
43endocardial cushion development (GO:0003197)4.73251438
442-oxoglutarate metabolic process (GO:0006103)4.71533103
45regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.70728820
46ventricular cardiac muscle cell action potential (GO:0086005)4.69731323
47* striated muscle adaptation (GO:0014888)4.67062610
48lysine metabolic process (GO:0006553)4.66209674
49lysine catabolic process (GO:0006554)4.66209674
50regulation of the force of heart contraction (GO:0002026)4.61449326
51regulation of heart rate by cardiac conduction (GO:0086091)4.58435282
52glyoxylate metabolic process (GO:0046487)4.56008176
53positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.55353213
54* adult heart development (GO:0007512)4.54729264
55* muscle tissue morphogenesis (GO:0060415)4.51667536
56actin-mediated cell contraction (GO:0070252)4.48897300
57* cardiac muscle adaptation (GO:0014887)4.48817248
58* cardiac muscle hypertrophy in response to stress (GO:0014898)4.48817248
59* muscle hypertrophy in response to stress (GO:0003299)4.48817248
60* regulation of sarcomere organization (GO:0060297)4.47478544
61regulation of renal sodium excretion (GO:0035813)4.47190335
62regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.46799558
63regulation of cardioblast proliferation (GO:0003264)4.46152854
64regulation of secondary heart field cardioblast proliferation (GO:0003266)4.46152854
65response to inactivity (GO:0014854)4.45744324
66* heart trabecula formation (GO:0060347)4.44736708
67cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.41223763
68negative regulation of potassium ion transport (GO:0043267)4.39917355
69* actomyosin structure organization (GO:0031032)4.38860447
70heart contraction (GO:0060047)4.36899287
71heart process (GO:0003015)4.36899287
72regulation of vascular permeability (GO:0043114)4.35319034
73negative regulation of systemic arterial blood pressure (GO:0003085)4.32519166
74cardiac conduction (GO:0061337)4.26378451
75fatty acid beta-oxidation (GO:0006635)4.23701600
76* regulation of cardiac muscle contraction (GO:0055117)4.15692819
77response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.12424329
78aspartate family amino acid catabolic process (GO:0009068)4.08730367
79* muscle adaptation (GO:0043500)4.08370597
80striated muscle contraction (GO:0006941)4.07792189
81cell communication involved in cardiac conduction (GO:0086065)4.05358838
82regulation of acyl-CoA biosynthetic process (GO:0050812)4.04556621
83venous blood vessel morphogenesis (GO:0048845)4.04519683
84negative regulation of myoblast differentiation (GO:0045662)3.98970425
85negative regulation of heart growth (GO:0061117)3.97489852
86negative regulation of cardiac muscle tissue growth (GO:0055022)3.97489852
87regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.97090246
88cellular ketone body metabolic process (GO:0046950)3.94363411
89* positive regulation of cardiac muscle tissue growth (GO:0055023)3.93052676
90* positive regulation of cardiac muscle cell proliferation (GO:0060045)3.88655306
91sarcoplasmic reticulum calcium ion transport (GO:0070296)3.88003109
92regulation of excretion (GO:0044062)3.84186788
93* regulation of striated muscle contraction (GO:0006942)3.81993475
94mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.81445989
95regulation of cell communication by electrical coupling (GO:0010649)3.80774971
96negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.78709852
97carnitine transmembrane transport (GO:1902603)3.78594565
98cardiac septum development (GO:0003279)3.77870860
99cell communication by electrical coupling (GO:0010644)3.77546276
100regulation of coenzyme metabolic process (GO:0051196)3.72784763
101regulation of cofactor metabolic process (GO:0051193)3.72784763
102relaxation of cardiac muscle (GO:0055119)3.72153377
103regulation of fatty acid oxidation (GO:0046320)3.69415952
104regulation of cardioblast differentiation (GO:0051890)3.68876271
105fatty acid oxidation (GO:0019395)3.66562641
106fatty acid catabolic process (GO:0009062)3.65719670
107lipid oxidation (GO:0034440)3.59095706
108* regulation of heart contraction (GO:0008016)3.59042931
109negative regulation of myotube differentiation (GO:0010832)3.57599995
110positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.54363078
111acetyl-CoA metabolic process (GO:0006084)3.53882251
112carnitine transport (GO:0015879)3.53324065
113amino-acid betaine transport (GO:0015838)3.53324065
114* positive regulation of heart growth (GO:0060421)3.52633751
115energy coupled proton transport, down electrochemical gradient (GO:0015985)3.52088812
116ATP synthesis coupled proton transport (GO:0015986)3.52088812
117L-phenylalanine catabolic process (GO:0006559)3.51773186
118erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.51773186
119succinate metabolic process (GO:0006105)3.51614790
120regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.50538110
121outflow tract septum morphogenesis (GO:0003148)3.50400982
122erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.47504150
123L-phenylalanine metabolic process (GO:0006558)3.47504150
124NADH metabolic process (GO:0006734)3.47099877
125regulation of ATP catabolic process (GO:1903289)3.46550391
126regulation of ATPase activity (GO:0043462)3.46550391
127regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.44744894
128regulation of membrane repolarization (GO:0060306)3.44429204
129tricarboxylic acid metabolic process (GO:0072350)3.43879160
130oxidative phosphorylation (GO:0006119)3.43114225
131detection of calcium ion (GO:0005513)3.41759668
132* positive regulation of cardiac muscle tissue development (GO:0055025)3.39126163
133cardiac muscle tissue development (GO:0048738)3.38719352
134gap junction assembly (GO:0016264)3.38455356
135kynurenine metabolic process (GO:0070189)3.38183580
136oxaloacetate metabolic process (GO:0006107)3.37951751
137actin filament-based movement (GO:0030048)3.37940565
138ketone body metabolic process (GO:1902224)3.37030783
139regulation of cardiac muscle cell contraction (GO:0086004)3.34220710
140carnitine metabolic process (GO:0009437)3.33897228
141monocarboxylic acid catabolic process (GO:0072329)3.32809394
142triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.31486661
143plasma membrane repair (GO:0001778)3.31408676
144amino-acid betaine metabolic process (GO:0006577)3.30887272
145branched-chain amino acid catabolic process (GO:0009083)3.29763836
146cardiac muscle cell action potential involved in contraction (GO:0086002)3.29242586
147regulation of sequestering of triglyceride (GO:0010889)3.28944288
148respiratory electron transport chain (GO:0022904)3.28780463
149regulation of heart rate (GO:0002027)3.28606249
150regulation of skeletal muscle contraction (GO:0014819)3.25392444
151cardiac muscle cell action potential (GO:0086001)3.24058891
152receptor guanylyl cyclase signaling pathway (GO:0007168)12.6980976

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.11049413
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse7.68912762
3RXR_22158963_ChIP-Seq_LIVER_Mouse5.23885997
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.75238722
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.41743233
6EP300_21415370_ChIP-Seq_HL-1_Mouse4.16197424
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.79112460
8ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.59573236
9TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.59478870
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.44505624
11* TBX20_22080862_ChIP-Seq_HEART_Mouse3.02325027
12* TBX20_22328084_ChIP-Seq_HEART_Mouse3.02325027
13EGR1_23403033_ChIP-Seq_LIVER_Mouse3.00488669
14EZH2_22144423_ChIP-Seq_EOC_Human2.66748452
15CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.43256755
16CLOCK_20551151_ChIP-Seq_293T_Human2.42602420
17RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.41042824
18TRIM28_21343339_ChIP-Seq_HEK293_Human2.33575563
19MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.25000490
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.24782947
21ESR1_20079471_ChIP-ChIP_T-47D_Human2.24595731
22ZNF263_19887448_ChIP-Seq_K562_Human2.17391932
23GATA1_22025678_ChIP-Seq_K562_Human2.14838326
24CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.12185053
25RARG_19884340_ChIP-ChIP_MEFs_Mouse2.03506105
26NFIB_24661679_ChIP-Seq_LUNG_Mouse1.89396354
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.89117564
28PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.88738762
29GATA4_21415370_ChIP-Seq_HL-1_Mouse1.77235407
30SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.65034233
31EZH2_27304074_Chip-Seq_ESCs_Mouse1.61298435
32EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.55692675
33PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.53296077
34SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.45945256
35CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.45818436
36TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.43631851
37AHR_22903824_ChIP-Seq_MCF-7_Human1.42941022
38PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.42934606
39NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.42920956
40HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.42906304
41FOXA2_19822575_ChIP-Seq_HepG2_Human1.42039783
42PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.40542634
43CDX2_19796622_ChIP-Seq_MESCs_Mouse1.40067706
44ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.39425500
45SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.34567992
46* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.32824865
47DROSHA_22980978_ChIP-Seq_HELA_Human1.32651652
48NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.30062498
49ZNF217_24962896_ChIP-Seq_MCF-7_Human1.29908035
50CTNNB1_20460455_ChIP-Seq_HCT116_Human1.27859077
51GATA1_19941826_ChIP-Seq_K562_Human1.24673774
52EZH2_18974828_ChIP-Seq_MESCs_Mouse1.22844370
53RNF2_18974828_ChIP-Seq_MESCs_Mouse1.22844370
54RNF2_27304074_Chip-Seq_ESCs_Mouse1.22525944
55* GATA1_19941827_ChIP-Seq_MEL86_Mouse1.22034501
56SALL4_18804426_ChIP-ChIP_XEN_Mouse1.20371576
57ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.19045333
58EZH2_27294783_Chip-Seq_ESCs_Mouse1.19015217
59TBL1_22424771_ChIP-Seq_293T_Human1.18493168
60AUTS2_25519132_ChIP-Seq_293T-REX_Human1.16137123
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.15948368
62EED_16625203_ChIP-ChIP_MESCs_Mouse1.15245813
63* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.14640760
64LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.13450274
65TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12968072
66GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.12051511
67TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.11884316
68MTF2_20144788_ChIP-Seq_MESCs_Mouse1.10005737
69SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.09403706
70AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09361795
71CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.08262683
72ISL1_27105846_Chip-Seq_CPCs_Mouse1.07466784
73WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05735312
74EGR1_19032775_ChIP-ChIP_M12_Human1.05692171
75ESR2_21235772_ChIP-Seq_MCF-7_Human1.04953321
76SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.04190807
77RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.00839364
78PCGF2_27294783_Chip-Seq_NPCs_Mouse1.00467056
79PPAR_26484153_Chip-Seq_NCI-H1993_Human1.00446862
80SUZ12_27294783_Chip-Seq_ESCs_Mouse0.99839996
81NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99061254
82ARNT_22903824_ChIP-Seq_MCF-7_Human0.98995468
83SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.96358829
84SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95252791
85NFYA_21822215_ChIP-Seq_K562_Human0.93986578
86TP53_16413492_ChIP-PET_HCT116_Human0.92253666
87RING1B_27294783_Chip-Seq_ESCs_Mouse0.91138338
88* SMAD4_21799915_ChIP-Seq_A2780_Human0.91128368
89HNF4A_19822575_ChIP-Seq_HepG2_Human0.91103550
90SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.90200384
91BP1_19119308_ChIP-ChIP_Hs578T_Human0.90163004
92WT1_19549856_ChIP-ChIP_CCG9911_Human0.89355856
93HIF1A_21447827_ChIP-Seq_MCF-7_Human0.89083886
94KDM2B_26808549_Chip-Seq_K562_Human0.87822629
95PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.87588596
96SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87107403
97* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.86604200
98HTT_18923047_ChIP-ChIP_STHdh_Human0.86231823
99NFYB_21822215_ChIP-Seq_K562_Human0.85541328
100JARID2_20064375_ChIP-Seq_MESCs_Mouse0.84959887
101CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.84718007
102NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.83619303
103STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.83414598
104SMAD_19615063_ChIP-ChIP_OVARY_Human0.83398519
105SUZ12_27294783_Chip-Seq_NPCs_Mouse0.82840476
106GATA2_19941826_ChIP-Seq_K562_Human0.82792649
107HNFA_21074721_ChIP-Seq_CACO-2_Human0.82446732
108RING1B_27294783_Chip-Seq_NPCs_Mouse0.79791245
109PHF8_20622853_ChIP-Seq_HELA_Human0.79602475
110* TCF4_18268006_ChIP-ChIP_LS174T_Human0.78370784
111MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.78267718
112GATA2_21666600_ChIP-Seq_HMVEC_Human0.78144714
113GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.77094181
114BCAT_22108803_ChIP-Seq_LS180_Human0.76905704
115SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.76060721
116NRF2_20460467_ChIP-Seq_MEFs_Mouse0.75754814
117NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.75754814
118TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.75263657
119TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.74088212
120CTCF_27219007_Chip-Seq_Bcells_Human0.73816858
121NR3C1_23031785_ChIP-Seq_PC12_Mouse0.73496334
122KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.71289089
123RACK7_27058665_Chip-Seq_MCF-7_Human0.70854156
124STAT3_1855785_ChIP-Seq_MESCs_Mouse0.69968272
125FOXO3_23340844_ChIP-Seq_DLD1_Human0.69217026
126SOX2_27498859_Chip-Seq_STOMACH_Mouse0.69086002
127RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.67990048
128AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.67374862
129LXR_22292898_ChIP-Seq_THP-1_Human0.66561478
130ELK3_25401928_ChIP-Seq_HUVEC_Human0.64660129
131* GATA1_19941827_ChIP-Seq_MEL_Mouse0.62404357
132STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.61980981
133ATF3_27146783_Chip-Seq_COLON_Human0.61789123
134SMAD4_21741376_ChIP-Seq_HESCs_Human0.61572988
135TP63_22573176_ChIP-Seq_HFKS_Human0.61085915
136CJUN_26792858_Chip-Seq_BT549_Human0.61033972
137SPI1_20517297_ChIP-Seq_HL60_Human0.60396516
138KDM2B_26808549_Chip-Seq_SUP-B15_Human0.59599759
139HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.58137781
140CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.56679505
141SOX9_24532713_ChIP-Seq_HFSC_Mouse0.56281385
142ZFP281_18757296_ChIP-ChIP_E14_Mouse0.54942612
143CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.54553600
144SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.54478688
145RUNX1_27514584_Chip-Seq_MCF-7_Human0.54334904
146SOX2_21211035_ChIP-Seq_LN229_Gbm0.53689224
147ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.52303510
148SMAD3_21741376_ChIP-Seq_HESCs_Human0.52084870
149PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.52035350
150OCT4_20526341_ChIP-Seq_ESCs_Human0.51489971
151CBP_21632823_ChIP-Seq_H3396_Human0.50423634
152SMC3_22415368_ChIP-Seq_MEFs_Mouse0.48620281
153* GATA4_25053715_ChIP-Seq_YYC3_Human0.48437239

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004084_abnormal_cardiac_muscle6.02207266
2MP0002837_dystrophic_cardiac_calcinosis5.45325199
3MP0004215_abnormal_myocardial_fiber4.30880479
4MP0004036_abnormal_muscle_relaxation4.06270361
5MP0005330_cardiomyopathy3.94932279
6MP0000751_myopathy3.72717224
7MP0008775_abnormal_heart_ventricle3.61355454
8MP0003646_muscle_fatigue3.38400668
9MP0002972_abnormal_cardiac_muscle3.13423431
10MP0005085_abnormal_gallbladder_physiolo2.97341315
11MP0005360_urolithiasis2.81293443
12MP0002139_abnormal_hepatobiliary_system2.80925412
13MP0000749_muscle_degeneration2.79992790
14MP0001544_abnormal_cardiovascular_syste2.67936357
15MP0005385_cardiovascular_system_phenoty2.67936357
16MP0003137_abnormal_impulse_conducting2.65235915
17MP0004087_abnormal_muscle_fiber2.62857148
18MP0006138_congestive_heart_failure2.57600480
19* MP0010630_abnormal_cardiac_muscle2.52400812
20MP0005503_abnormal_tendon_morphology2.39884071
21MP0003828_pulmonary_edema2.38372652
22MP0004130_abnormal_muscle_cell2.37798993
23MP0005620_abnormal_muscle_contractility2.35877796
24MP0005365_abnormal_bile_salt2.28614471
25MP0008004_abnormal_stomach_pH2.24062910
26* MP0004085_abnormal_heartbeat2.21735620
27MP0003806_abnormal_nucleotide_metabolis2.19365634
28MP0005451_abnormal_body_composition2.16963473
29MP0004484_altered_response_of1.94696631
30MP0003221_abnormal_cardiomyocyte_apopto1.92594551
31MP0002127_abnormal_cardiovascular_syste1.88962640
32MP0004510_myositis1.87509782
33MP0000750_abnormal_muscle_regeneration1.85980551
34MP0002106_abnormal_muscle_physiology1.84380100
35MP0006036_abnormal_mitochondrial_physio1.84206421
36MP0008875_abnormal_xenobiotic_pharmacok1.81877568
37MP0002269_muscular_atrophy1.81005230
38MP0010368_abnormal_lymphatic_system1.66950545
39MP0003567_abnormal_fetal_cardiomyocyte1.60769110
40MP0003252_abnormal_bile_duct1.48304262
41MP0005369_muscle_phenotype1.43501023
42MP0009840_abnormal_foam_cell1.41078031
43MP0005332_abnormal_amino_acid1.39046280
44MP0000747_muscle_weakness1.35938960
45MP0004145_abnormal_muscle_electrophysio1.33065948
46MP0010329_abnormal_lipoprotein_level1.31487265
47MP0005083_abnormal_biliary_tract1.28726822
48MP0003950_abnormal_plasma_membrane1.24327497
49MP0002295_abnormal_pulmonary_circulatio1.23237570
50MP0000759_abnormal_skeletal_muscle1.21692680
51MP0004233_abnormal_muscle_weight1.15799222
52MP0003705_abnormal_hypodermis_morpholog1.15341591
53MP0003195_calcinosis1.14495127
54MP0005666_abnormal_adipose_tissue1.12706587
55MP0001661_extended_life_span1.12350996
56MP0005319_abnormal_enzyme/_coenzyme1.12200383
57* MP0000266_abnormal_heart_morphology1.09619050
58MP0003279_aneurysm1.07355042
59MP0006035_abnormal_mitochondrial_morpho1.07213383
60MP0002332_abnormal_exercise_endurance1.05624861
61MP0004272_abnormal_basement_membrane1.03467645
62MP0005165_increased_susceptibility_to1.02458642
63MP0002118_abnormal_lipid_homeostasis1.01745815
64MP0009384_cardiac_valve_regurgitation1.01489655
65MP0000013_abnormal_adipose_tissue0.99712934
66MP0000343_altered_response_to0.96214945
67MP0000230_abnormal_systemic_arterial0.93467654
68MP0005584_abnormal_enzyme/coenzyme_acti0.92859452
69MP0002128_abnormal_blood_circulation0.89874655
70MP0003566_abnormal_cell_adhesion0.86448237
71MP0003191_abnormal_cellular_cholesterol0.86018843
72MP0000609_abnormal_liver_physiology0.85294195
73MP0005266_abnormal_metabolism0.80519526
74MP0001666_abnormal_nutrient_absorption0.78743556
75MP0000767_abnormal_smooth_muscle0.77661271
76MP0005670_abnormal_white_adipose0.77335123
77MP0001958_emphysema0.74993098
78MP0008874_decreased_physiological_sensi0.71929071
79MP0004185_abnormal_adipocyte_glucose0.69386783
80MP0005409_darkened_coat_color0.68735506
81MP0003045_fibrosis0.67698482
82MP0002078_abnormal_glucose_homeostasis0.66060807
83MP0009697_abnormal_copulation0.64953630
84MP0005375_adipose_tissue_phenotype0.62239623
85MP0009643_abnormal_urine_homeostasis0.62162905
86MP0001879_abnormal_lymphatic_vessel0.60802421
87MP0002234_abnormal_pharynx_morphology0.60214799
88MP0008438_abnormal_cutaneous_collagen0.59607000
89MP0001784_abnormal_fluid_regulation0.59564263
90MP0002971_abnormal_brown_adipose0.57256706
91MP0001299_abnormal_eye_distance/0.56882436
92MP0001348_abnormal_lacrimal_gland0.55402963
93MP0003122_maternal_imprinting0.55339651
94MP0003656_abnormal_erythrocyte_physiolo0.51564544
95MP0005535_abnormal_body_temperature0.50857687
96MP0005187_abnormal_penis_morphology0.50494774
97MP0000598_abnormal_liver_morphology0.48819551
98MP0005508_abnormal_skeleton_morphology0.46847688
99MP0001614_abnormal_blood_vessel0.45642546
100MP0005167_abnormal_blood-brain_barrier0.45390492
101MP0005623_abnormal_meninges_morphology0.44875274
102MP0005275_abnormal_skin_tensile0.44866185
103MP0009763_increased_sensitivity_to0.43630940
104MP0002088_abnormal_embryonic_growth/wei0.43208994
105MP0002108_abnormal_muscle_morphology0.43053283
106MP0003984_embryonic_growth_retardation0.40956986
107MP0003091_abnormal_cell_migration0.40933301
108MP0004043_abnormal_pH_regulation0.40878627
109MP0000249_abnormal_blood_vessel0.40562516
110* MP0002925_abnormal_cardiovascular_devel0.40217342
111MP0005376_homeostasis/metabolism_phenot0.40188980
112MP0005595_abnormal_vascular_smooth0.40094943
113MP0003186_abnormal_redox_activity0.39645530
114MP0009642_abnormal_blood_homeostasis0.38218986
115MP0001727_abnormal_embryo_implantation0.36455693
116MP0003948_abnormal_gas_homeostasis0.35169579
117MP0000733_abnormal_muscle_development0.33881404
118MP0002933_joint_inflammation0.31749598
119MP0005023_abnormal_wound_healing0.30843199
120MP0005390_skeleton_phenotype0.29412927
121MP0003634_abnormal_glial_cell0.29215688
122MP0005164_abnormal_response_to0.26959235
123MP0004924_abnormal_behavior0.26648181
124MP0005386_behavior/neurological_phenoty0.26648181
125MP0001533_abnormal_skeleton_physiology0.26066381
126MP0000163_abnormal_cartilage_morphology0.25560322
127MP0002998_abnormal_bone_remodeling0.24684735
128MP0002115_abnormal_skeleton_extremities0.24502390
129MP0009115_abnormal_fat_cell0.24002573
130MP0009250_abnormal_appendicular_skeleto0.21915219
131MP0002877_abnormal_melanocyte_morpholog0.21781943
132MP0001730_embryonic_growth_arrest0.21021240
133MP0002089_abnormal_postnatal_growth/wei0.20560596

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)7.27259758
2Ventricular tachycardia (HP:0004756)6.07952934
3Bradycardia (HP:0001662)5.92484659
4Atrial fibrillation (HP:0005110)5.66639867
5Primary atrial arrhythmia (HP:0001692)5.27416087
6Supraventricular tachycardia (HP:0004755)5.09309060
7Supraventricular arrhythmia (HP:0005115)4.99903168
8Lipoatrophy (HP:0100578)4.90797377
9Calf muscle hypertrophy (HP:0008981)4.86596515
10Exercise-induced muscle cramps (HP:0003710)4.67570141
11Myoglobinuria (HP:0002913)4.64521772
12Right ventricular cardiomyopathy (HP:0011663)4.61910338
13Syncope (HP:0001279)4.61060043
14Abnormality of the left ventricular outflow tract (HP:0011103)4.57340562
15Subaortic stenosis (HP:0001682)4.57340562
16Hypoplastic left heart (HP:0004383)4.55178906
17Abnormality of the calf musculature (HP:0001430)4.34771007
18Muscle hypertrophy of the lower extremities (HP:0008968)4.31834504
19Palpitations (HP:0001962)4.29954358
20Hypoglycemic coma (HP:0001325)4.24907206
21Exercise-induced myalgia (HP:0003738)4.24415191
22Dilated cardiomyopathy (HP:0001644)4.09886946
23Wrist flexion contracture (HP:0001239)4.07796340
24Anomalous pulmonary venous return (HP:0010772)4.07075956
25Ventricular arrhythmia (HP:0004308)4.03050569
26Partial duplication of thumb phalanx (HP:0009944)3.97105979
27Aplasia of the musculature (HP:0100854)3.84585659
28Asymmetric septal hypertrophy (HP:0001670)3.74898965
29Muscle fiber splitting (HP:0003555)3.69524209
30Prolonged QT interval (HP:0001657)3.68653477
31Atrioventricular block (HP:0001678)3.61948179
32Hypoplastic heart (HP:0001961)3.60305767
33Abnormality of fatty-acid metabolism (HP:0004359)3.55707210
34Abnormality of the pulmonary veins (HP:0011718)3.55248517
35Ketoacidosis (HP:0001993)3.51588697
36Rhabdomyolysis (HP:0003201)3.48469968
37Hyporeflexia of lower limbs (HP:0002600)3.46826006
38Partial duplication of the phalanx of hand (HP:0009999)3.45080924
39Heart block (HP:0012722)3.36857658
40Ketosis (HP:0001946)3.30081198
41Ragged-red muscle fibers (HP:0003200)3.30055330
42Hyperammonemia (HP:0001987)3.28504089
43Congenital malformation of the right heart (HP:0011723)3.28192385
44Double outlet right ventricle (HP:0001719)3.28192385
45Dicarboxylic aciduria (HP:0003215)3.25746853
46Abnormality of dicarboxylic acid metabolism (HP:0010995)3.25746853
47Bundle branch block (HP:0011710)3.23344117
48Ventricular fibrillation (HP:0001663)3.20746472
49Abnormal atrioventricular conduction (HP:0005150)3.14382780
50Deep venous thrombosis (HP:0002625)3.13439280
51Hepatic necrosis (HP:0002605)3.11829866
52Distal lower limb amyotrophy (HP:0008944)3.09447466
53Cerebral edema (HP:0002181)3.02077387
54EMG: myopathic abnormalities (HP:0003458)2.99185072
55Bulbar palsy (HP:0001283)2.88402707
56Abnormality of the tricuspid valve (HP:0001702)2.83010760
57Rimmed vacuoles (HP:0003805)2.82732337
58Conjunctival hamartoma (HP:0100780)2.72860668
59Increased connective tissue (HP:0009025)2.70758337
60Abnormal mitochondria in muscle tissue (HP:0008316)2.70473622
61Hyperglycinuria (HP:0003108)2.69995653
62Intrahepatic cholestasis (HP:0001406)2.68586717
63Generalized aminoaciduria (HP:0002909)2.62099164
64Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.61880623
65Acute encephalopathy (HP:0006846)2.61288600
66Abnormal EKG (HP:0003115)2.59049040
67Xanthomatosis (HP:0000991)2.57586076
68Acute necrotizing encephalopathy (HP:0006965)2.57144509
69Abnormality of the foot musculature (HP:0001436)2.56932465
70Hypoalphalipoproteinemia (HP:0003233)2.56273205
71Proximal amyotrophy (HP:0007126)2.53255588
72Foot dorsiflexor weakness (HP:0009027)2.50145703
73Neck muscle weakness (HP:0000467)2.49967676
74Palmoplantar keratoderma (HP:0000982)2.49314482
75Arthropathy (HP:0003040)2.48491086
76Abnormality of aromatic amino acid family metabolism (HP:0004338)2.48040821
77Patent foramen ovale (HP:0001655)2.47975908
78Abnormality of glycine metabolism (HP:0010895)2.47618340
79Abnormality of serine family amino acid metabolism (HP:0010894)2.47618340
80Hyperlipoproteinemia (HP:0010980)2.42233354
81Left ventricular hypertrophy (HP:0001712)2.42224018
82Pulmonary artery stenosis (HP:0004415)2.40294629
83Lower limb amyotrophy (HP:0007210)2.40015057
84Increased variability in muscle fiber diameter (HP:0003557)2.37991973
85Neoplasm of the adrenal gland (HP:0100631)2.36292887
86Increased serum pyruvate (HP:0003542)2.32719549
87Abnormality of glycolysis (HP:0004366)2.32719549
88Areflexia of lower limbs (HP:0002522)2.31829468
89Hepatocellular necrosis (HP:0001404)2.29989423
90Abnormality of skeletal muscle fiber size (HP:0012084)2.27535136
91Metabolic acidosis (HP:0001942)2.26367215
92Increased muscle lipid content (HP:0009058)2.25731914
93Complete atrioventricular canal defect (HP:0001674)2.25726916
94Nausea (HP:0002018)2.25171176
95Difficulty climbing stairs (HP:0003551)2.25007786
96Lymphangioma (HP:0100764)2.24884439
97Sudden cardiac death (HP:0001645)2.24811327
98Pheochromocytoma (HP:0002666)2.23483680
99Skin nodule (HP:0200036)2.22701254
100Aplasia/Hypoplasia involving the musculature (HP:0001460)2.22672643
101Hyperinsulinemic hypoglycemia (HP:0000825)2.22615664
102Hypolipoproteinemia (HP:0010981)2.21172294
103Dysmetric saccades (HP:0000641)2.17352149
104Hyperglycinemia (HP:0002154)2.17069890
105Complement deficiency (HP:0004431)2.14394822
106Myotonia (HP:0002486)2.12646152
107Progressive macrocephaly (HP:0004481)2.11983635
108Cholelithiasis (HP:0001081)2.11408150
109Prolonged partial thromboplastin time (HP:0003645)2.10695033
110EMG: neuropathic changes (HP:0003445)2.10620252
111Lethargy (HP:0001254)2.10068024
112Proximal tubulopathy (HP:0000114)2.08323777
113Lactic acidosis (HP:0003128)2.07415264
114Increased CSF lactate (HP:0002490)2.07300835
115Multiple enchondromatosis (HP:0005701)2.07089810
116Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.03266621
117Hypobetalipoproteinemia (HP:0003563)2.02373004
118Mildly elevated creatine phosphokinase (HP:0008180)2.02204685
119Mitochondrial inheritance (HP:0001427)2.01233727
120Centrally nucleated skeletal muscle fibers (HP:0003687)1.98453144
121Cavernous hemangioma (HP:0001048)1.98380015
122Congestive heart failure (HP:0001635)1.96709522
123Abnormality of monocarboxylic acid metabolism (HP:0010996)1.96679189
124Abnormal gallbladder morphology (HP:0012437)1.96539459
125Renal cortical cysts (HP:0000803)1.95527966
126Hyperglycemia (HP:0003074)1.94599843
127Distal lower limb muscle weakness (HP:0009053)1.94499182
128Hamartoma of the eye (HP:0010568)1.93790166
129Duplication of thumb phalanx (HP:0009942)1.93488130
130Increased intramyocellular lipid droplets (HP:0012240)1.92936285
131Pancreatic islet-cell hyperplasia (HP:0004510)1.92719270
132Neuroendocrine neoplasm (HP:0100634)1.92671367
133Generalized muscle weakness (HP:0003324)1.92639880
134Difficulty running (HP:0009046)1.90997738
135Esophageal neoplasm (HP:0100751)1.90231739
136Neoplasm of head and neck (HP:0012288)1.90231739
137Steppage gait (HP:0003376)1.83192904
138Preauricular pit (HP:0004467)1.82134097
139Periauricular skin pits (HP:0100277)1.82134097
140Transposition of the great arteries (HP:0001669)1.81066814
141Abnormal connection of the cardiac segments (HP:0011545)1.81066814
142Abnormal ventriculo-arterial connection (HP:0011563)1.81066814
143Atrioventricular canal defect (HP:0006695)1.76873110
144Truncus arteriosus (HP:0001660)1.74862456
145Abnormality of the shoulder girdle musculature (HP:0001435)1.72694109
146Limb-girdle muscle atrophy (HP:0003797)1.71292325
147Abnormality of the thoracic spine (HP:0100711)1.70671225
148Muscular dystrophy (HP:0003560)1.66347906
149Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.65309384
150Skin pits (HP:0100276)1.63126255
151Abnormality of complement system (HP:0005339)1.60662657
152Aneurysm (HP:0002617)1.58884526
153Mitral stenosis (HP:0001718)1.58091272
154Vertebral arch anomaly (HP:0008438)1.57411780
155Gowers sign (HP:0003391)1.55710942
156Spontaneous hematomas (HP:0007420)1.53413753
157Stroke (HP:0001297)1.51795517
158Vascular calcification (HP:0004934)1.51519075
159Fatigable weakness (HP:0003473)1.51513993
160Abnormality of the neuromuscular junction (HP:0003398)1.51513993
161Hematochezia (HP:0002573)1.47040631
162Muscle fiber inclusion bodies (HP:0100299)1.44104109
163Scapular winging (HP:0003691)1.43808092
164Esophageal varix (HP:0002040)1.43340493

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PKN25.03657874
2TTN4.98948871
3OBSCN4.05204192
4MYLK3.95490107
5LMTK23.74325278
6PDK33.32099672
7PDK43.32099672
8BCKDK3.23455530
9TRIB33.09209870
10STK242.84917980
11PHKG12.83190359
12PHKG22.83190359
13TIE12.69254056
14NEK12.44108768
15DMPK2.42701020
16FLT31.97533099
17PIK3CA1.94701442
18PDK21.92848076
19PINK11.51801289
20INSRR1.48694672
21CDC42BPA1.39810472
22ILK1.37086458
23MARK11.30163248
24PAK31.28566203
25GRK71.25618077
26MAP3K61.19982367
27PRKD11.18073457
28KDR1.07750366
29STK38L1.06896765
30MAP3K71.06265481
31FGFR41.05949715
32DAPK31.04401244
33SIK11.03951310
34WNK41.03401714
35EPHA41.02847175
36ZAK1.01944443
37CAMK2D0.98281507
38EPHA30.98043507
39TGFBR10.97146318
40PRKAA20.96402796
41SGK20.94391928
42TRPM70.92373653
43ROCK10.92280185
44MUSK0.92220710
45MAPK120.91187526
46CAMK40.89571330
47STK40.87607752
48PRPF4B0.87181894
49RIPK10.83970923
50MAPK40.82861656
51NLK0.81686715
52PRKAA10.80059354
53PTK60.78963218
54TGFBR20.78629284
55NEK90.76652674
56MAP2K30.75934156
57PTK2B0.74519669
58CSK0.72714786
59CAMK2A0.69692010
60LATS10.68209062
61MAP3K50.67871825
62SGK4940.67583694
63SGK2230.67583694
64MAP3K30.66906275
65CAMK10.65694315
66STK390.63624823
67RPS6KA20.61919401
68MAP3K100.58597494
69PDGFRA0.57105703
70UHMK10.53883552
71ITK0.53021760
72MAP2K10.52154572
73PRKACG0.51068341
74EPHB10.50641794
75PKN10.50215633
76MAPK110.49972709
77CAMK2B0.49601225
78STK110.48970626
79STK380.48935504
80DDR20.46531088
81FGFR30.46375173
82RET0.45349325
83ERN10.43984538
84MAP2K40.43898088
85WNK10.43661424
86PRKACB0.43248180
87KSR20.41308437
88ZAP700.41090060
89MAPKAPK30.40398800
90PDK10.40213657
91CAMK2G0.39817280
92LIMK10.39633929
93MELK0.37841488
94MARK20.37726355
95PDGFRB0.36240994
96PRKACA0.35960099
97JAK20.35615448
98RPS6KC10.34332421
99RPS6KL10.34332421
100LRRK20.34327146
101PDPK10.34232723
102JAK10.32815581
103PRKD20.31926367
104PRKD30.31212697
105PRKCE0.31002065
106LATS20.30772140
107ICK0.29857288
108ROCK20.29757778
109HIPK20.29671065
110TYK20.28514584
111FGFR10.27350386
112PRKCQ0.26710431
113RPS6KA60.26188430
114FES0.25937489
115PRKG20.25026029
116CDK40.23062262
117AKT20.22945809
118AKT10.21907667
119MAPK70.21088214
120ADRBK10.20097713
121RPS6KA30.18808492
122FER0.18758700
123SRC0.18445261
124MET0.18333222
125ERBB40.18086411
126FYN0.17139153
127PAK20.16876098
128SGK30.16436429
129PRKCH0.16430923
130CDK50.16334027
131EPHB20.16203498
132MTOR0.16110023
133RPS6KA10.15596920
134PRKG10.14543477
135RPS6KA50.14451662
136RAF10.14167620

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.63457943
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.99196799
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.89491018
4Fatty acid degradation_Homo sapiens_hsa000713.57005199
5Propanoate metabolism_Homo sapiens_hsa006403.30296387
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.02108646
7Cardiac muscle contraction_Homo sapiens_hsa042602.77352130
8Fatty acid metabolism_Homo sapiens_hsa012122.67631861
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.62365516
10Carbon metabolism_Homo sapiens_hsa012002.42967386
11Primary bile acid biosynthesis_Homo sapiens_hsa001202.32588911
12Dilated cardiomyopathy_Homo sapiens_hsa054142.29648169
13Butanoate metabolism_Homo sapiens_hsa006502.23425823
14Arginine biosynthesis_Homo sapiens_hsa002202.20566336
15Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.19651586
16Pyruvate metabolism_Homo sapiens_hsa006202.05238893
17Tryptophan metabolism_Homo sapiens_hsa003802.04675585
18Parkinsons disease_Homo sapiens_hsa050121.88908621
19Nitrogen metabolism_Homo sapiens_hsa009101.83148031
20Fatty acid elongation_Homo sapiens_hsa000621.81971519
21Oxidative phosphorylation_Homo sapiens_hsa001901.77217353
22Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.76439167
23Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.75806238
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.71247629
25PPAR signaling pathway_Homo sapiens_hsa033201.71027029
26Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.59566429
27Linoleic acid metabolism_Homo sapiens_hsa005911.56963857
28Biosynthesis of amino acids_Homo sapiens_hsa012301.56026975
29beta-Alanine metabolism_Homo sapiens_hsa004101.47141394
30Circadian rhythm_Homo sapiens_hsa047101.46501219
31Peroxisome_Homo sapiens_hsa041461.45724240
32Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.39570302
33Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.35837941
34Arachidonic acid metabolism_Homo sapiens_hsa005901.35807322
35Starch and sucrose metabolism_Homo sapiens_hsa005001.34115164
36Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.33916803
37Complement and coagulation cascades_Homo sapiens_hsa046101.32905382
38Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.31609523
39Alzheimers disease_Homo sapiens_hsa050101.29588203
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.29481500
41Phenylalanine metabolism_Homo sapiens_hsa003601.24103814
42Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.08363236
43Huntingtons disease_Homo sapiens_hsa050161.03217559
44Regulation of actin cytoskeleton_Homo sapiens_hsa048101.02285298
45Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.99080771
46Pentose and glucuronate interconversions_Homo sapiens_hsa000400.97504151
47Lysine degradation_Homo sapiens_hsa003100.96330753
48Cysteine and methionine metabolism_Homo sapiens_hsa002700.94164528
49Bile secretion_Homo sapiens_hsa049760.92186934
50Tyrosine metabolism_Homo sapiens_hsa003500.90287084
51Arginine and proline metabolism_Homo sapiens_hsa003300.88422776
52Pancreatic secretion_Homo sapiens_hsa049720.87459407
53Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.87216362
54TGF-beta signaling pathway_Homo sapiens_hsa043500.86695032
55Insulin resistance_Homo sapiens_hsa049310.83301871
56Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.81344410
57Insulin secretion_Homo sapiens_hsa049110.81082633
58Caffeine metabolism_Homo sapiens_hsa002320.80359583
59Aldosterone synthesis and secretion_Homo sapiens_hsa049250.80284152
60Circadian entrainment_Homo sapiens_hsa047130.76192467
61Glucagon signaling pathway_Homo sapiens_hsa049220.75342603
62Platelet activation_Homo sapiens_hsa046110.74877407
63Chemical carcinogenesis_Homo sapiens_hsa052040.74719396
64Viral myocarditis_Homo sapiens_hsa054160.71851704
65Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.71016564
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.68975036
67Histidine metabolism_Homo sapiens_hsa003400.67747537
68Adipocytokine signaling pathway_Homo sapiens_hsa049200.67600497
69Fat digestion and absorption_Homo sapiens_hsa049750.67544537
70Staphylococcus aureus infection_Homo sapiens_hsa051500.65994517
71Gap junction_Homo sapiens_hsa045400.63071468
72Regulation of autophagy_Homo sapiens_hsa041400.62674268
73Selenocompound metabolism_Homo sapiens_hsa004500.61324358
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.59818110
75FoxO signaling pathway_Homo sapiens_hsa040680.59531839
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.58895238
77mTOR signaling pathway_Homo sapiens_hsa041500.57433613
78Phospholipase D signaling pathway_Homo sapiens_hsa040720.57351344
79Amphetamine addiction_Homo sapiens_hsa050310.56798081
80alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.56234101
81Galactose metabolism_Homo sapiens_hsa000520.55681373
82Cholinergic synapse_Homo sapiens_hsa047250.55645138
83Long-term potentiation_Homo sapiens_hsa047200.55469660
84Cyanoamino acid metabolism_Homo sapiens_hsa004600.55391505
85GnRH signaling pathway_Homo sapiens_hsa049120.55300757
86Leukocyte transendothelial migration_Homo sapiens_hsa046700.54945920
87Steroid hormone biosynthesis_Homo sapiens_hsa001400.54194286
88Mineral absorption_Homo sapiens_hsa049780.53789576
89Gastric acid secretion_Homo sapiens_hsa049710.53243226
90Estrogen signaling pathway_Homo sapiens_hsa049150.52494092
91ABC transporters_Homo sapiens_hsa020100.52331034
92cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51293376
93Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50926032
94Sulfur metabolism_Homo sapiens_hsa009200.50897730
95Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.50810820
96Retinol metabolism_Homo sapiens_hsa008300.50171855
97Serotonergic synapse_Homo sapiens_hsa047260.49615602
98Drug metabolism - other enzymes_Homo sapiens_hsa009830.47987297
99Taste transduction_Homo sapiens_hsa047420.47876984
100Fatty acid biosynthesis_Homo sapiens_hsa000610.47797760
101Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47482085
102Fructose and mannose metabolism_Homo sapiens_hsa000510.44796583
103Morphine addiction_Homo sapiens_hsa050320.44390490
104Insulin signaling pathway_Homo sapiens_hsa049100.43354305
105Renal cell carcinoma_Homo sapiens_hsa052110.42502680
106Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.42184852
107Proteoglycans in cancer_Homo sapiens_hsa052050.42142842
108AMPK signaling pathway_Homo sapiens_hsa041520.40149829
109Cocaine addiction_Homo sapiens_hsa050300.40009827
110MAPK signaling pathway_Homo sapiens_hsa040100.39637034
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.39184685
112Metabolic pathways_Homo sapiens_hsa011000.38882206
113Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.38718752
114AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.37530965
115HIF-1 signaling pathway_Homo sapiens_hsa040660.36921360
116PI3K-Akt signaling pathway_Homo sapiens_hsa041510.35957243
117Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.35722592
118Axon guidance_Homo sapiens_hsa043600.35433111
119VEGF signaling pathway_Homo sapiens_hsa043700.33533370
120Pentose phosphate pathway_Homo sapiens_hsa000300.31825208
121Glycerolipid metabolism_Homo sapiens_hsa005610.31690124
122GABAergic synapse_Homo sapiens_hsa047270.30497939
123Glycerophospholipid metabolism_Homo sapiens_hsa005640.28085959
124Focal adhesion_Homo sapiens_hsa045100.28068631
125Endometrial cancer_Homo sapiens_hsa052130.27009530
126Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.26824184
127Rap1 signaling pathway_Homo sapiens_hsa040150.24183833
128Glutathione metabolism_Homo sapiens_hsa004800.23755181
129Thyroid hormone synthesis_Homo sapiens_hsa049180.23115210
130Inositol phosphate metabolism_Homo sapiens_hsa005620.22255998
131Melanogenesis_Homo sapiens_hsa049160.20554746
132ECM-receptor interaction_Homo sapiens_hsa045120.17703245
133Type II diabetes mellitus_Homo sapiens_hsa049300.16118788
134Vascular smooth muscle contraction_Homo sapiens_hsa042700.13919800
135Tight junction_Homo sapiens_hsa045300.13058775
136Folate biosynthesis_Homo sapiens_hsa007900.12911434
137Calcium signaling pathway_Homo sapiens_hsa040200.12877739
138Amoebiasis_Homo sapiens_hsa051460.09923060
139Sulfur relay system_Homo sapiens_hsa041220.09831834
140Oxytocin signaling pathway_Homo sapiens_hsa049210.06062381
141Ovarian steroidogenesis_Homo sapiens_hsa049130.05721505
142Prion diseases_Homo sapiens_hsa050200.05179061
143Longevity regulating pathway - mammal_Homo sapiens_hsa042110.05156712
144Thyroid hormone signaling pathway_Homo sapiens_hsa049190.02360332
145Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.02144434
146cAMP signaling pathway_Homo sapiens_hsa040240.01196392
147Taurine and hypotaurine metabolism_Homo sapiens_hsa00430-0.0242364
148Adherens junction_Homo sapiens_hsa04520-0.0219040
149Renin secretion_Homo sapiens_hsa04924-0.0141884

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