BLMH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Bleomycin hydrolase (BMH) is a cytoplasmic cysteine peptidase that is highly conserved through evolution; however, the only known activity of the enzyme is metabolic inactivation of the glycopeptide bleomycin (BLM), an essential component of combination chemotherapy regimens for cancer. The protein contains the signature active site residues of the cysteine protease papain superfamily. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of DNA damage checkpoint (GO:2000001)5.14183949
2regulation of double-strand break repair via homologous recombination (GO:0010569)5.01271956
3DNA unwinding involved in DNA replication (GO:0006268)5.00270385
4DNA replication initiation (GO:0006270)4.50062814
5DNA strand elongation involved in DNA replication (GO:0006271)4.45578006
6renal system development (GO:0072001)4.44805981
7DNA strand elongation (GO:0022616)4.28570278
8regulation of helicase activity (GO:0051095)4.01978009
9telomere maintenance via semi-conservative replication (GO:0032201)4.01309175
10nucleobase biosynthetic process (GO:0046112)3.91920829
11DNA replication-dependent nucleosome assembly (GO:0006335)3.90430032
12DNA replication-dependent nucleosome organization (GO:0034723)3.90430032
13IMP biosynthetic process (GO:0006188)3.88950347
14regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.88914373
15double-strand break repair via nonhomologous end joining (GO:0006303)3.87227986
16non-recombinational repair (GO:0000726)3.87227986
17establishment of integrated proviral latency (GO:0075713)3.81842842
18kinetochore organization (GO:0051383)3.79942728
19pore complex assembly (GO:0046931)3.78979075
20ribosomal small subunit assembly (GO:0000028)3.77154162
21protein localization to kinetochore (GO:0034501)3.76504879
22meiotic chromosome segregation (GO:0045132)3.75787700
23mitotic G1 DNA damage checkpoint (GO:0031571)3.75568588
24chromatin remodeling at centromere (GO:0031055)3.75272581
25CENP-A containing nucleosome assembly (GO:0034080)3.74122367
26ribosomal large subunit biogenesis (GO:0042273)3.70987778
27mRNA cleavage (GO:0006379)3.69768791
28purine nucleobase biosynthetic process (GO:0009113)3.68187104
29DNA replication checkpoint (GO:0000076)3.66025084
30mitotic recombination (GO:0006312)3.62476284
31viral mRNA export from host cell nucleus (GO:0046784)3.58813141
32telomere maintenance via recombination (GO:0000722)3.56682153
33kinetochore assembly (GO:0051382)3.55361605
34transcription-coupled nucleotide-excision repair (GO:0006283)3.54916210
35nuclear pore organization (GO:0006999)3.54529058
36mitotic sister chromatid segregation (GO:0000070)3.51968538
37formation of translation preinitiation complex (GO:0001731)3.50145381
38spliceosomal snRNP assembly (GO:0000387)3.49998085
39base-excision repair (GO:0006284)3.49118053
40mitotic metaphase plate congression (GO:0007080)3.49026507
41G1 DNA damage checkpoint (GO:0044783)3.46973564
42mismatch repair (GO:0006298)3.44031894
43DNA replication-independent nucleosome organization (GO:0034724)3.43933969
44DNA replication-independent nucleosome assembly (GO:0006336)3.43933969
45negative regulation of mitotic sister chromatid separation (GO:2000816)3.42470849
46negative regulation of mitotic sister chromatid segregation (GO:0033048)3.42470849
47negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.42470849
48negative regulation of sister chromatid segregation (GO:0033046)3.42470849
49nucleotide-excision repair, DNA gap filling (GO:0006297)3.41305268
50telomere maintenance (GO:0000723)3.41051947
51telomere maintenance via telomere lengthening (GO:0010833)3.40996796
52spindle assembly checkpoint (GO:0071173)3.39655998
53regulation of sister chromatid cohesion (GO:0007063)3.39329125
54telomere organization (GO:0032200)3.38972258
55mitotic spindle assembly checkpoint (GO:0007094)3.38833706
56negative regulation of chromosome segregation (GO:0051985)3.38189998
57peptidyl-arginine omega-N-methylation (GO:0035247)3.37071636
58sister chromatid segregation (GO:0000819)3.36185210
59mitotic G1/S transition checkpoint (GO:0044819)3.36088080
60mitotic nuclear envelope disassembly (GO:0007077)3.35681478
61maturation of SSU-rRNA (GO:0030490)3.35160836
62negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.33645554
63attachment of spindle microtubules to kinetochore (GO:0008608)3.32945631
64positive regulation of histone H3-K4 methylation (GO:0051571)3.32564946
65nucleotide-excision repair, DNA damage removal (GO:0000718)3.31837198
66DNA excision (GO:0044349)3.31837198
67negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.31306610
68regulation of double-strand break repair (GO:2000779)3.30730538
69nuclear pore complex assembly (GO:0051292)3.29736077
70IMP metabolic process (GO:0046040)3.29308757
71negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.28466873
72spindle checkpoint (GO:0031577)3.28214348
73anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.27239459
74mitotic spindle checkpoint (GO:0071174)3.24269891
75ribonucleoprotein complex biogenesis (GO:0022613)3.22414218
76folic acid-containing compound biosynthetic process (GO:0009396)3.21147854
77heterochromatin organization (GO:0070828)3.21022479
78histone arginine methylation (GO:0034969)3.20883239
79metaphase plate congression (GO:0051310)3.20103347
80termination of RNA polymerase II transcription (GO:0006369)3.20059156
81DNA ligation (GO:0006266)3.19340017
82regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.19175682
83ATP-dependent chromatin remodeling (GO:0043044)3.18919591
84lactate metabolic process (GO:0006089)3.18479941
85molting cycle (GO:0042303)3.18349859
86hair cycle (GO:0042633)3.18349859
87positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.16588922
88somatic diversification of immune receptors via somatic mutation (GO:0002566)3.16545722
89somatic hypermutation of immunoglobulin genes (GO:0016446)3.16545722
90negative regulation of RNA splicing (GO:0033119)3.13318076
91regulation of mitotic metaphase/anaphase transition (GO:0030071)3.12590487
92ribosome assembly (GO:0042255)3.12432285
93maturation of 5.8S rRNA (GO:0000460)3.12097755
94cullin deneddylation (GO:0010388)3.12065172
95ribosome biogenesis (GO:0042254)3.12064033
96mitotic chromosome condensation (GO:0007076)3.11286758
97translational termination (GO:0006415)3.11241060
98histone exchange (GO:0043486)3.10663525
99DNA catabolic process, exonucleolytic (GO:0000738)3.09560538
100DNA duplex unwinding (GO:0032508)3.09301177
101nuclear envelope disassembly (GO:0051081)3.08702950
102membrane disassembly (GO:0030397)3.08702950
103negative regulation of mRNA metabolic process (GO:1903312)3.08509826
104negative regulation of DNA-dependent DNA replication (GO:2000104)3.08371897
105positive regulation of chromosome segregation (GO:0051984)3.08327830
106regulation of mitotic sister chromatid separation (GO:0010965)3.08118080
107regulation of mitotic sister chromatid segregation (GO:0033047)3.08118080
108regulation of sister chromatid segregation (GO:0033045)3.08118080
109DNA geometric change (GO:0032392)3.08023327
110viral transcription (GO:0019083)3.06743073
111regulation of chromosome segregation (GO:0051983)3.06592249
112spliceosomal complex assembly (GO:0000245)3.06521904
113regulation of cell cycle checkpoint (GO:1901976)3.06333299
114regulation of posttranscriptional gene silencing (GO:0060147)3.05116504
115regulation of gene silencing by miRNA (GO:0060964)3.05116504
116regulation of gene silencing by RNA (GO:0060966)3.05116504
117intra-S DNA damage checkpoint (GO:0031573)3.04897459
118regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.04642674
119regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.03428822
120protein localization to chromosome, centromeric region (GO:0071459)3.02184298
121negative regulation of ligase activity (GO:0051352)3.02043903
122negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.02043903
123chromatin assembly or disassembly (GO:0006333)3.00714810
124telomere maintenance via telomerase (GO:0007004)3.00054610
125ribosomal small subunit biogenesis (GO:0042274)2.99429131
126rRNA processing (GO:0006364)2.98798397
127V(D)J recombination (GO:0033151)2.98099444
128chromatin assembly (GO:0031497)2.97563638
129maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.96462208
130multicellular organismal aging (GO:0010259)2.96394475
131protein K6-linked ubiquitination (GO:0085020)2.95368835
132DNA replication (GO:0006260)2.94170577
133cell cycle G1/S phase transition (GO:0044843)2.93964848
134G1/S transition of mitotic cell cycle (GO:0000082)2.93964848
135establishment of chromosome localization (GO:0051303)2.93732111
136rRNA metabolic process (GO:0016072)2.91642185
137DNA topological change (GO:0006265)2.91574032
138translational initiation (GO:0006413)2.90997936
139protein localization to chromosome (GO:0034502)2.90703262
140histone mRNA metabolic process (GO:0008334)2.90329046
141negative regulation of mRNA processing (GO:0050686)2.89834889
142nucleotide-excision repair (GO:0006289)2.89419994
143negative regulation of mitosis (GO:0045839)2.88934586
144RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.88400368
145mRNA splicing, via spliceosome (GO:0000398)2.88400368

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.61750697
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.50436020
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.28063665
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.97601366
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.70844492
6* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.30348487
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.28515376
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.20086553
9MYC_19079543_ChIP-ChIP_MESCs_Mouse3.17347870
10GABP_17652178_ChIP-ChIP_JURKAT_Human3.01437081
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.94642900
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.93535514
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.79616882
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.69182164
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.66552076
16* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.63871930
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.63474617
18* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.53394823
19MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.33905177
20* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.33542667
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.29445991
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.28404679
23XRN2_22483619_ChIP-Seq_HELA_Human2.26852826
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.26649459
25AR_21909140_ChIP-Seq_LNCAP_Human2.25656515
26TP63_19390658_ChIP-ChIP_HaCaT_Human2.20835348
27CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.11667695
28THAP11_20581084_ChIP-Seq_MESCs_Mouse2.06980529
29YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.06044342
30E2F1_18555785_ChIP-Seq_MESCs_Mouse2.03599169
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.03410785
32TTF2_22483619_ChIP-Seq_HELA_Human1.98362413
33VDR_23849224_ChIP-Seq_CD4+_Human1.93247095
34FOXP3_21729870_ChIP-Seq_TREG_Human1.92376041
35MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.92368777
36RBPJ_22232070_ChIP-Seq_NCS_Mouse1.91733771
37ELK1_19687146_ChIP-ChIP_HELA_Human1.90458358
38E2F1_21310950_ChIP-Seq_MCF-7_Human1.85721125
39DCP1A_22483619_ChIP-Seq_HELA_Human1.85222014
40ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.83292559
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.76483303
42MYCN_18555785_ChIP-Seq_MESCs_Mouse1.75849722
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71425013
44SOX2_18555785_ChIP-Seq_MESCs_Mouse1.70840508
45SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.70395075
46EGR1_19374776_ChIP-ChIP_THP-1_Human1.69520137
47SALL1_21062744_ChIP-ChIP_HESCs_Human1.64672264
48GABP_19822575_ChIP-Seq_HepG2_Human1.63943334
49POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.63589980
50POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.61010359
51NANOG_18555785_ChIP-Seq_MESCs_Mouse1.60929690
52TP63_17297297_ChIP-ChIP_HaCaT_Human1.49515557
53KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.49327911
54* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.48243931
55ZFX_18555785_ChIP-Seq_MESCs_Mouse1.47392273
56YY1_21170310_ChIP-Seq_MESCs_Mouse1.46945012
57KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.44098692
58KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.44098692
59KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.44098692
60CIITA_25753668_ChIP-Seq_RAJI_Human1.40287850
61PADI4_21655091_ChIP-ChIP_MCF-7_Human1.38373865
62HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.38328543
63CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.34083302
64CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.33572419
65HOXB4_20404135_ChIP-ChIP_EML_Mouse1.31982448
66PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.30747153
67MYC_18940864_ChIP-ChIP_HL60_Human1.29906006
68POU5F1_16153702_ChIP-ChIP_HESCs_Human1.29596509
69SRF_21415370_ChIP-Seq_HL-1_Mouse1.26434875
70KDM5A_27292631_Chip-Seq_BREAST_Human1.22960531
71FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.21163635
72MYC_22102868_ChIP-Seq_BL_Human1.17064241
73CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.16274328
74TFEB_21752829_ChIP-Seq_HELA_Human1.13355613
75CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.08578899
76SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.07430114
77POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.04492317
78NANOG_16153702_ChIP-ChIP_HESCs_Human1.04367843
79E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.04049834
80ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.03672526
81ESR1_15608294_ChIP-ChIP_MCF-7_Human1.03193245
82TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.02259536
83CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.01518681
84SOX2_16153702_ChIP-ChIP_HESCs_Human1.00841760
85E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.99962115
86NOTCH1_21737748_ChIP-Seq_TLL_Human0.98921183
87SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.98789257
88SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.96068817
89DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.95376920
90NANOG_21062744_ChIP-ChIP_HESCs_Human0.92760578
91BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.91521085
92TCF3_18692474_ChIP-Seq_MEFs_Mouse0.90048237
93CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.90020582
94ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.88880392
95GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.88657682
96TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.87419285
97STAT3_1855785_ChIP-Seq_MESCs_Mouse0.86536705
98SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.85685039
99NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.84725950
100IRF1_19129219_ChIP-ChIP_H3396_Human0.84347703
101ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.81891711
102EWS_26573619_Chip-Seq_HEK293_Human0.81286775
103* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.81232034
104* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.80130674
105TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.79896588
106ELK1_22589737_ChIP-Seq_MCF10A_Human0.79155729
107KLF4_18555785_ChIP-Seq_MESCs_Mouse0.78037826
108SOX17_20123909_ChIP-Seq_XEN_Mouse0.77039490
109KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.76977842
110CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.75235810
111TCF3_18692474_ChIP-Seq_MESCs_Mouse0.74899552
112FUS_26573619_Chip-Seq_HEK293_Human0.74484918
113FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.73973698
114SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.73957330
115PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.73290479
116TBX5_21415370_ChIP-Seq_HL-1_Mouse0.68556546
117CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.64873830
118CHD1_26751641_Chip-Seq_LNCaP_Human0.61397729

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.12008205
2MP0004957_abnormal_blastocyst_morpholog3.78800836
3MP0003693_abnormal_embryo_hatching3.72047585
4MP0003123_paternal_imprinting3.62353586
5MP0003111_abnormal_nucleus_morphology3.57844727
6MP0003077_abnormal_cell_cycle3.31031050
7MP0008057_abnormal_DNA_replication3.17660698
8MP0008058_abnormal_DNA_repair3.14199483
9MP0003121_genomic_imprinting2.91191571
10MP0008932_abnormal_embryonic_tissue2.64104507
11MP0008877_abnormal_DNA_methylation2.62271842
12MP0003122_maternal_imprinting2.49026968
13MP0008007_abnormal_cellular_replicative2.40344963
14MP0003941_abnormal_skin_development2.38875823
15MP0010307_abnormal_tumor_latency2.28056101
16MP0003890_abnormal_embryonic-extraembry2.19664942
17MP0002796_impaired_skin_barrier2.04977029
18MP0005501_abnormal_skin_physiology1.97038448
19MP0003315_abnormal_perineum_morphology1.94087975
20MP0010030_abnormal_orbit_morphology1.92687479
21MP0001730_embryonic_growth_arrest1.84153651
22MP0000537_abnormal_urethra_morphology1.75191564
23MP0004133_heterotaxia1.74717718
24MP0000350_abnormal_cell_proliferation1.74032882
25MP0002098_abnormal_vibrissa_morphology1.70071055
26MP0003786_premature_aging1.68247702
27MP0009053_abnormal_anal_canal1.68154960
28MP0009697_abnormal_copulation1.66858086
29MP0003937_abnormal_limbs/digits/tail_de1.65770639
30MP0000579_abnormal_nail_morphology1.61835759
31MP0008995_early_reproductive_senescence1.61769551
32MP0005171_absent_coat_pigmentation1.61633499
33MP0000372_irregular_coat_pigmentation1.60231877
34MP0008789_abnormal_olfactory_epithelium1.56221001
35MP0002085_abnormal_embryonic_tissue1.54127247
36MP0000762_abnormal_tongue_morphology1.48314721
37MP0000566_synostosis1.47502819
38MP0004197_abnormal_fetal_growth/weight/1.47399793
39MP0002084_abnormal_developmental_patter1.45067909
40MP0002938_white_spotting1.43022440
41MP0001697_abnormal_embryo_size1.42109434
42MP0000467_abnormal_esophagus_morphology1.41483221
43MP0003119_abnormal_digestive_system1.41406161
44MP0000383_abnormal_hair_follicle1.38366622
45MP0005380_embryogenesis_phenotype1.36900696
46MP0001672_abnormal_embryogenesis/_devel1.36900696
47MP0003567_abnormal_fetal_cardiomyocyte1.31743927
48MP0005499_abnormal_olfactory_system1.30656045
49MP0005394_taste/olfaction_phenotype1.30656045
50MP0001188_hyperpigmentation1.30001832
51MP0003718_maternal_effect1.26938253
52* MP0002111_abnormal_tail_morphology1.26352488
53MP0000647_abnormal_sebaceous_gland1.24910871
54MP0003787_abnormal_imprinting1.23734701
55MP0002080_prenatal_lethality1.19663181
56MP0006292_abnormal_olfactory_placode1.19471614
57MP0000049_abnormal_middle_ear1.16835784
58MP0002102_abnormal_ear_morphology1.16088235
59MP0003385_abnormal_body_wall1.15135085
60MP0009379_abnormal_foot_pigmentation1.13215927
61MP0003984_embryonic_growth_retardation1.12240628
62MP0003938_abnormal_ear_development1.11638653
63MP0002088_abnormal_embryonic_growth/wei1.11055517
64MP0003942_abnormal_urinary_system1.10951970
65MP0010678_abnormal_skin_adnexa1.09656584
66MP0002396_abnormal_hematopoietic_system1.09111995
67MP0001286_abnormal_eye_development1.08612126
68MP0006035_abnormal_mitochondrial_morpho1.07647138
69MP0001529_abnormal_vocalization1.06862907
70MP0000377_abnormal_hair_follicle1.06383181
71MP0001293_anophthalmia1.05990939
72MP0002282_abnormal_trachea_morphology1.05961829
73MP0003221_abnormal_cardiomyocyte_apopto1.05748576
74MP0003755_abnormal_palate_morphology1.04776319
75MP0004808_abnormal_hematopoietic_stem1.04413114
76MP0002086_abnormal_extraembryonic_tissu1.01746742
77MP0002210_abnormal_sex_determination1.01280675
78MP0005075_abnormal_melanosome_morpholog1.01088277
79MP0002653_abnormal_ependyma_morphology1.00792581
80MP0009672_abnormal_birth_weight0.98394149
81MP0002877_abnormal_melanocyte_morpholog0.98180535
82MP0000428_abnormal_craniofacial_morphol0.97602898
83MP0005409_darkened_coat_color0.97121643
84MP0004381_abnormal_hair_follicle0.96897232
85MP0002751_abnormal_autonomic_nervous0.95635895
86* MP0001216_abnormal_epidermal_layer0.94693545
87MP0009250_abnormal_appendicular_skeleto0.94366759
88MP0002092_abnormal_eye_morphology0.91892004
89MP0005275_abnormal_skin_tensile0.91465005
90MP0002095_abnormal_skin_pigmentation0.90965127
91MP0010771_integument_phenotype0.90938275
92MP0003136_yellow_coat_color0.90129464
93MP0000313_abnormal_cell_death0.89936271
94MP0003935_abnormal_craniofacial_develop0.89775883
95MP0003861_abnormal_nervous_system0.87999623
96MP0002697_abnormal_eye_size0.87742383
97MP0000432_abnormal_head_morphology0.87651751
98MP0005451_abnormal_body_composition0.87511273
99MP0010352_gastrointestinal_tract_polyps0.86842478
100MP0001145_abnormal_male_reproductive0.84362849
101MP0002233_abnormal_nose_morphology0.84252254
102MP0002249_abnormal_larynx_morphology0.84223412
103MP0005647_abnormal_sex_gland0.84017419
104MP0000358_abnormal_cell_content/0.82636973
105MP0005187_abnormal_penis_morphology0.81905898
106MP0002234_abnormal_pharynx_morphology0.81807276
107MP0001661_extended_life_span0.81086456
108MP0001929_abnormal_gametogenesis0.79135352
109MP0002160_abnormal_reproductive_system0.78053974
110MP0002177_abnormal_outer_ear0.76677249
111MP0005248_abnormal_Harderian_gland0.75585777
112MP0004147_increased_porphyrin_level0.75487876
113MP0005408_hypopigmentation0.75341240
114MP0000678_abnormal_parathyroid_gland0.75086559
115MP0002116_abnormal_craniofacial_bone0.74787493
116MP0002932_abnormal_joint_morphology0.74217347
117MP0000613_abnormal_salivary_gland0.73425370
118MP0000703_abnormal_thymus_morphology0.72724818
119MP0003943_abnormal_hepatobiliary_system0.72571187
120MP0000490_abnormal_crypts_of0.72396487
121MP0000427_abnormal_hair_cycle0.71901650
122MP0006054_spinal_hemorrhage0.71828999
123MP0002109_abnormal_limb_morphology0.70905068
124MP0003115_abnormal_respiratory_system0.70602314
125MP0000653_abnormal_sex_gland0.70364997
126MP0002019_abnormal_tumor_incidence0.70219066
127MP0006036_abnormal_mitochondrial_physio0.70113671
128MP0002114_abnormal_axial_skeleton0.69455968
129MP0004233_abnormal_muscle_weight0.69422428
130MP0001243_abnormal_dermal_layer0.68099914
131MP0009703_decreased_birth_body0.67634602
132MP0006072_abnormal_retinal_apoptosis0.66103730
133MP0005391_vision/eye_phenotype0.62972858
134MP0001346_abnormal_lacrimal_gland0.60455463
135MP0001119_abnormal_female_reproductive0.59960658

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cochlea (HP:0000375)4.94849213
2Back pain (HP:0003418)4.57126595
3Oral leukoplakia (HP:0002745)4.13510306
4Birth length less than 3rd percentile (HP:0003561)3.83284545
5Morphological abnormality of the inner ear (HP:0011390)3.76018305
6Chromsome breakage (HP:0040012)3.69447799
7Chromosomal breakage induced by crosslinking agents (HP:0003221)3.68989487
8Colon cancer (HP:0003003)3.49991744
9Abnormality of nail color (HP:0100643)3.47581045
10Medulloblastoma (HP:0002885)3.44427616
11Reticulocytopenia (HP:0001896)3.42177954
12Microvesicular hepatic steatosis (HP:0001414)3.10150475
13Abnormal lung lobation (HP:0002101)3.07578319
14Abnormality of the labia minora (HP:0012880)3.02958299
15Selective tooth agenesis (HP:0001592)3.00276627
16Breech presentation (HP:0001623)2.99847712
17Meckel diverticulum (HP:0002245)2.94259725
18Nephroblastoma (Wilms tumor) (HP:0002667)2.92085503
19Abnormality of glycolysis (HP:0004366)2.90453573
20Increased serum pyruvate (HP:0003542)2.90453573
21Volvulus (HP:0002580)2.89116617
22Abnormal number of incisors (HP:0011064)2.88180473
23Aplastic anemia (HP:0001915)2.87834709
24Embryonal renal neoplasm (HP:0011794)2.87436156
25Abnormality of the ileum (HP:0001549)2.86628119
26Patellar aplasia (HP:0006443)2.84374194
27Abnormality of the preputium (HP:0100587)2.83574628
28Acute lymphatic leukemia (HP:0006721)2.78785310
29Ependymoma (HP:0002888)2.69337372
30Aplasia/Hypoplasia of the uvula (HP:0010293)2.68048461
31Cerebral hypomyelination (HP:0006808)2.61983268
32Aplasia/Hypoplasia of the patella (HP:0006498)2.60321829
33Breast hypoplasia (HP:0003187)2.58434781
34Abnormality of chromosome stability (HP:0003220)2.55828866
35Esophageal atresia (HP:0002032)2.51734133
36Hypoplastic labia majora (HP:0000059)2.50135522
37Supernumerary spleens (HP:0009799)2.48110379
38Small intestinal stenosis (HP:0012848)2.44065997
39Duodenal stenosis (HP:0100867)2.44065997
40Agnosia (HP:0010524)2.39374769
41Rhabdomyosarcoma (HP:0002859)2.37788980
42Duplicated collecting system (HP:0000081)2.37088455
43Short 4th metacarpal (HP:0010044)2.31268419
44Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.31268419
45Absent radius (HP:0003974)2.30924377
46Facial cleft (HP:0002006)2.29338114
47Cystic liver disease (HP:0006706)2.29158004
48Increased nuchal translucency (HP:0010880)2.26175603
49Hyperglycinemia (HP:0002154)2.26075139
50Microglossia (HP:0000171)2.24985450
51Oligodactyly (HP:0012165)2.24493845
52Hemivertebrae (HP:0002937)2.24134998
53Abnormality of the labia majora (HP:0012881)2.24113287
54Atresia of the external auditory canal (HP:0000413)2.22132628
55Aplasia cutis congenita (HP:0001057)2.21924422
56Clitoromegaly (HP:0000057)2.20740105
57Proximal placement of thumb (HP:0009623)2.19166868
58Absent forearm bone (HP:0003953)2.17995237
59Aplasia involving forearm bones (HP:0009822)2.17995237
60Cutaneous finger syndactyly (HP:0010554)2.17604836
61Absent thumb (HP:0009777)2.17021041
62Aplasia/Hypoplasia of the sternum (HP:0006714)2.16123575
63High anterior hairline (HP:0009890)2.12294869
64Blepharitis (HP:0000498)2.11682514
65Carpal bone hypoplasia (HP:0001498)2.11370706
66Abnormality of the duodenum (HP:0002246)2.10208741
67Cutaneous syndactyly (HP:0012725)2.09626415
68Premature graying of hair (HP:0002216)2.08091737
69Facial hemangioma (HP:0000329)2.06518703
70Deviation of the thumb (HP:0009603)2.05768830
71Macrocytic anemia (HP:0001972)2.04226491
72Abnormality of the renal collecting system (HP:0004742)2.03624923
73Hypotrichosis (HP:0001006)2.01029401
74Glossoptosis (HP:0000162)2.00074857
75Triphalangeal thumb (HP:0001199)2.00047137
76Neoplasm of the pancreas (HP:0002894)1.96907715
77Irregular epiphyses (HP:0010582)1.94870915
78Asplenia (HP:0001746)1.93165750
79Small hand (HP:0200055)1.92655791
80Abnormality of the carotid arteries (HP:0005344)1.90910322
81Rough bone trabeculation (HP:0100670)1.90287764
82Abnormality of cells of the erythroid lineage (HP:0012130)1.90013159
83Horseshoe kidney (HP:0000085)1.90010781
84Abnormal number of erythroid precursors (HP:0012131)1.88787939
85Neuroblastoma (HP:0003006)1.88091867
86Primitive neuroectodermal tumor (HP:0030065)1.88091867
87Neuroblastic tumors (HP:0004376)1.88091867
88Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.88091867
89Woolly hair (HP:0002224)1.87664569
90Ectopic kidney (HP:0000086)1.87573932
91Abnormality of chromosome segregation (HP:0002916)1.87158516
92Aplasia/Hypoplasia of the spleen (HP:0010451)1.86481196
93Progressive external ophthalmoplegia (HP:0000590)1.85929558
94Supernumerary bones of the axial skeleton (HP:0009144)1.85665332
95Multiple enchondromatosis (HP:0005701)1.82862659
96Prominent nose (HP:0000448)1.82781761
97Cafe-au-lait spot (HP:0000957)1.81170215
98Broad alveolar ridges (HP:0000187)1.80415535
99Pallor (HP:0000980)1.80147658
100Sparse eyelashes (HP:0000653)1.80079716
101Sloping forehead (HP:0000340)1.79663648
10211 pairs of ribs (HP:0000878)1.79344550
103Short middle phalanx of the 5th finger (HP:0004220)1.78936445
104Diastasis recti (HP:0001540)1.78696891
105Myelodysplasia (HP:0002863)1.78642757
106Neoplasm of striated muscle (HP:0009728)1.77578966
107Cellular immunodeficiency (HP:0005374)1.76802215
108Abnormality of the incisor (HP:0000676)1.76571852
109Tracheoesophageal fistula (HP:0002575)1.76157486
110Abnormality of the clitoris (HP:0000056)1.76153264
111Shoulder girdle muscle weakness (HP:0003547)1.75603979
112Abnormality of the labia (HP:0000058)1.73658222
113Neoplasm of the oral cavity (HP:0100649)1.73582226
114Clubbing of toes (HP:0100760)1.73398164
115Abnormality of abdominal situs (HP:0011620)1.73136713
116Abdominal situs inversus (HP:0003363)1.73136713
117Short palpebral fissure (HP:0012745)1.73123950
118Hypoplastic female external genitalia (HP:0012815)1.72276099
119Bone marrow hypocellularity (HP:0005528)1.71926407
120Dysphonia (HP:0001618)1.71001207
121Congenital ichthyosiform erythroderma (HP:0007431)1.70973738
122Shawl scrotum (HP:0000049)1.70416047
123Renal agenesis (HP:0000104)1.69987824
124Abnormality of the astrocytes (HP:0100707)1.69801270
125Astrocytoma (HP:0009592)1.69801270
126Progressive cerebellar ataxia (HP:0002073)1.69718482
127Microtia (HP:0008551)1.69480366
128Gastrointestinal atresia (HP:0002589)1.69233298
129Abnormality of hair growth rate (HP:0011363)1.68708539
130Slow-growing hair (HP:0002217)1.68708539
131Septo-optic dysplasia (HP:0100842)1.68137230
132Hypoplastic pelvis (HP:0008839)1.68003551
133Thin ribs (HP:0000883)1.67696570
134Bifid tongue (HP:0010297)1.67570458
135Prostate neoplasm (HP:0100787)1.67293252
136Supernumerary ribs (HP:0005815)1.66061590
137Aplasia/Hypoplasia of the sacrum (HP:0008517)1.65543168
138Hypoplasia of the capital femoral epiphysis (HP:0003090)1.65157352
139Abnormality of DNA repair (HP:0003254)1.65130810
140Abnormality of the alveolar ridges (HP:0006477)1.64361015
141Rimmed vacuoles (HP:0003805)1.63853963
142Breast aplasia (HP:0100783)1.63041266
143Erythroderma (HP:0001019)1.62856417
144Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.62648441
145Slender long bone (HP:0003100)1.62606895
146Ovarian neoplasm (HP:0100615)1.62566881
147Glioma (HP:0009733)1.60457771
148Hyperbilirubinemia (HP:0002904)1.60097064
149Embryonal neoplasm (HP:0002898)1.57682907
150Rectovaginal fistula (HP:0000143)1.57329527
151Rectal fistula (HP:0100590)1.57329527
152Labial hypoplasia (HP:0000066)1.57269497
153Trigonocephaly (HP:0000243)1.55671458
154Neoplasm of the colon (HP:0100273)1.54771646
155Capillary hemangiomas (HP:0005306)1.54249454

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.60648844
2CDC74.01647936
3MKNK13.18424437
4MKNK23.05379011
5SRPK13.02606677
6NEK12.99869260
7STK162.92697242
8WEE12.90063761
9TSSK62.82818452
10TTK2.42234149
11PASK2.41347601
12NME22.15001158
13STK38L2.09109506
14PLK31.92779072
15EIF2AK11.89347984
16KSR21.87975503
17MST41.82176061
18VRK21.82013133
19NEK21.81615032
20PLK11.80609332
21TGFBR11.80366308
22ACVR1B1.79173532
23ZAK1.76847901
24PLK41.76221262
25TIE11.72090105
26VRK11.72006683
27EIF2AK31.66597040
28TAOK21.61853086
29ATR1.60417639
30RPS6KB21.48313469
31CDK71.45363778
32TLK11.40690131
33AURKB1.35312775
34CHEK21.30339289
35LIMK11.26318792
36CHEK11.23600636
37AURKA1.21750759
38PBK1.21607740
39DYRK21.20655675
40TRIM281.19083201
41MAP3K81.17277444
42PAK41.17070293
43ALK1.11378527
44TESK21.08449699
45ILK1.06721142
46CDK41.06194553
47BRSK21.01421504
48CCNB11.01050862
49BCR0.99729557
50NUAK10.99100423
51BRD40.98549898
52MAP3K100.97549838
53KDR0.96888686
54BCKDK0.96348999
55CAMK1D0.95445696
56BRSK10.94376810
57AKT30.91826819
58PDK20.91252575
59ATM0.87828384
60LATS20.87764785
61DYRK30.87606759
62CAMK1G0.85065200
63TAF10.84929740
64EIF2AK20.83109622
65TESK10.82893308
66ERBB30.81490585
67BRAF0.79839203
68SIK30.79662883
69CDK10.79342502
70CDK80.76967128
71CDK20.75965931
72YES10.72787806
73SGK20.72529776
74CSNK2A10.70426304
75CSNK2A20.70221292
76BMPR1B0.69873082
77CLK10.69703535
78STK40.68284449
79CDK120.66977062
80PRKCI0.66540558
81PLK20.65705596
82NEK60.65319169
83CSNK1G10.64605577
84LATS10.63649078
85MAP3K30.63555454
86EPHB20.62311546
87CASK0.60680077
88PAK10.60074925
89STK100.58501516
90STK30.57819719
91SMG10.56345341
92KSR10.56028208
93ERBB40.55316139
94PAK60.54074554
95PIM10.53726292
96TEC0.53393639
97EEF2K0.52771821
98PNCK0.51803523
99CSNK1A1L0.51549795
100CSNK1G20.51322157
101DAPK10.50825126
102CSNK1E0.50379658
103FGFR10.49692537
104CDK30.48210726
105RAF10.43702627
106CDK190.41619608
107RPS6KA50.40024316
108CDK60.39573447
109AKT10.37351422
110NEK90.36976153
111CDK180.36216542
112PIK3CA0.36042374
113PRKDC0.35538471
114FGFR20.35386715
115STK240.34681328
116MINK10.34338567
117MAPK140.34320987
118TNIK0.33324179
119CDK11A0.32987618
120NME10.32580330
121WNK30.32226790
122CDK150.31612024
123CDK140.31136641
124RPS6KA40.30227369
125MET0.30051035
126AKT20.29554959
127CSNK1D0.27230244
128ADRBK10.27165138
129SCYL20.26649978
130OBSCN0.26426812
131ADRBK20.26389232
132RPS6KB10.26049025
133CSNK1G30.24653908
134MAP2K60.23737325

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.86037384
2Mismatch repair_Homo sapiens_hsa034304.59423952
3Proteasome_Homo sapiens_hsa030503.83340026
4Spliceosome_Homo sapiens_hsa030403.52625891
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.49035487
6Ribosome_Homo sapiens_hsa030103.31994952
7RNA transport_Homo sapiens_hsa030133.10566059
8Homologous recombination_Homo sapiens_hsa034403.08403345
9Base excision repair_Homo sapiens_hsa034102.89205147
10Nucleotide excision repair_Homo sapiens_hsa034202.88006748
11Cell cycle_Homo sapiens_hsa041102.84660183
12RNA polymerase_Homo sapiens_hsa030202.83648614
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.68597555
14One carbon pool by folate_Homo sapiens_hsa006702.67616334
15Fanconi anemia pathway_Homo sapiens_hsa034602.37650821
16Pyrimidine metabolism_Homo sapiens_hsa002402.14918689
17Non-homologous end-joining_Homo sapiens_hsa034502.11918855
18RNA degradation_Homo sapiens_hsa030182.10679411
19mRNA surveillance pathway_Homo sapiens_hsa030152.01153259
20Basal transcription factors_Homo sapiens_hsa030221.77115570
21Systemic lupus erythematosus_Homo sapiens_hsa053221.47662985
22p53 signaling pathway_Homo sapiens_hsa041151.37406484
23Propanoate metabolism_Homo sapiens_hsa006401.33571534
24Basal cell carcinoma_Homo sapiens_hsa052171.24752777
25Purine metabolism_Homo sapiens_hsa002301.20895843
26Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.16297809
27Cyanoamino acid metabolism_Homo sapiens_hsa004601.10629436
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.10372500
29Epstein-Barr virus infection_Homo sapiens_hsa051691.05357166
30Oocyte meiosis_Homo sapiens_hsa041141.01051943
31Hedgehog signaling pathway_Homo sapiens_hsa043400.95256619
32Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.93494677
33Parkinsons disease_Homo sapiens_hsa050120.93054589
34Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.91575036
35Hippo signaling pathway_Homo sapiens_hsa043900.90893782
36Oxidative phosphorylation_Homo sapiens_hsa001900.88944444
37Biosynthesis of amino acids_Homo sapiens_hsa012300.86555463
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.86438781
39Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.84025519
40Sulfur relay system_Homo sapiens_hsa041220.81544488
41Viral carcinogenesis_Homo sapiens_hsa052030.81441598
42Protein export_Homo sapiens_hsa030600.80042189
43Alcoholism_Homo sapiens_hsa050340.79544656
44Huntingtons disease_Homo sapiens_hsa050160.77898821
45Steroid biosynthesis_Homo sapiens_hsa001000.74898704
46Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.66650764
47Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.65750603
48HTLV-I infection_Homo sapiens_hsa051660.65401911
49TGF-beta signaling pathway_Homo sapiens_hsa043500.65370593
50Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.64816654
51Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.64550251
52Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.64182030
53Cysteine and methionine metabolism_Homo sapiens_hsa002700.63169420
54Carbon metabolism_Homo sapiens_hsa012000.57698110
55Herpes simplex infection_Homo sapiens_hsa051680.56851209
56Pentose phosphate pathway_Homo sapiens_hsa000300.55931537
57MicroRNAs in cancer_Homo sapiens_hsa052060.54951820
58Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.54674123
59Tyrosine metabolism_Homo sapiens_hsa003500.53910128
60Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.53354978
61Wnt signaling pathway_Homo sapiens_hsa043100.49590539
62Selenocompound metabolism_Homo sapiens_hsa004500.48819330
63Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.46979733
64Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46483513
65Fatty acid metabolism_Homo sapiens_hsa012120.45932561
66Fatty acid elongation_Homo sapiens_hsa000620.45240268
67Adherens junction_Homo sapiens_hsa045200.44764723
68Colorectal cancer_Homo sapiens_hsa052100.42768650
69Antigen processing and presentation_Homo sapiens_hsa046120.41724480
70Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.40791874
71Arachidonic acid metabolism_Homo sapiens_hsa005900.40243329
72Tight junction_Homo sapiens_hsa045300.39761198
73Pyruvate metabolism_Homo sapiens_hsa006200.38536403
74Glutathione metabolism_Homo sapiens_hsa004800.38511501
752-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.38428812
76Primary immunodeficiency_Homo sapiens_hsa053400.33615450
77Legionellosis_Homo sapiens_hsa051340.33608140
78Chronic myeloid leukemia_Homo sapiens_hsa052200.32955741
79Linoleic acid metabolism_Homo sapiens_hsa005910.31685114
80Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.31137406
81Pathways in cancer_Homo sapiens_hsa052000.30429209
82Notch signaling pathway_Homo sapiens_hsa043300.29735659
83Thyroid cancer_Homo sapiens_hsa052160.29368688
84Metabolic pathways_Homo sapiens_hsa011000.28173863
85Alzheimers disease_Homo sapiens_hsa050100.27073356
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.26911712
87Phototransduction_Homo sapiens_hsa047440.25106535
88Phenylalanine metabolism_Homo sapiens_hsa003600.22855015
89Non-small cell lung cancer_Homo sapiens_hsa052230.22345321
90Arginine and proline metabolism_Homo sapiens_hsa003300.21513002
91Pancreatic cancer_Homo sapiens_hsa052120.19907880
92Melanoma_Homo sapiens_hsa052180.19725192
93Axon guidance_Homo sapiens_hsa043600.19680164
94Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.18934545
95Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.17739397
96Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.16503787
97Drug metabolism - other enzymes_Homo sapiens_hsa009830.15671654
98Endometrial cancer_Homo sapiens_hsa052130.15256766
99Retinol metabolism_Homo sapiens_hsa008300.15032388
100N-Glycan biosynthesis_Homo sapiens_hsa005100.14936043
101Small cell lung cancer_Homo sapiens_hsa052220.14259319
102Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.14129721
103Prostate cancer_Homo sapiens_hsa052150.13903168
104PI3K-Akt signaling pathway_Homo sapiens_hsa041510.13763824
105Folate biosynthesis_Homo sapiens_hsa007900.13558678
106Ether lipid metabolism_Homo sapiens_hsa005650.13168350
107Bladder cancer_Homo sapiens_hsa052190.12399574
108Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.11874632
109Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.11481840
110Acute myeloid leukemia_Homo sapiens_hsa052210.10948254
111alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.10889397
112Galactose metabolism_Homo sapiens_hsa000520.10149933
113Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.08225692
114Renin-angiotensin system_Homo sapiens_hsa046140.07511883
115Central carbon metabolism in cancer_Homo sapiens_hsa052300.07034693
116Lysine degradation_Homo sapiens_hsa003100.05467482
117Butanoate metabolism_Homo sapiens_hsa006500.03179600
118Hepatitis B_Homo sapiens_hsa051610.01527683

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