BLID

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a BH3-like motif containing protein involved in cell death. The encoded protein may induce apoptosis in a caspase-dependent manner. The protein is localized in both the cytoplasm and the mitochondrion. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mesenchymal-epithelial cell signaling (GO:0060638)6.36214655
2protein retention in ER lumen (GO:0006621)5.12136066
3regulation of branching involved in salivary gland morphogenesis (GO:0060693)4.82250562
4retina vasculature morphogenesis in camera-type eye (GO:0061299)4.76383164
5maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.53529727
6negative regulation of cardiac muscle cell apoptotic process (GO:0010667)4.12633363
7axon extension involved in axon guidance (GO:0048846)4.07542968
8neuron projection extension involved in neuron projection guidance (GO:1902284)4.07542968
9barbed-end actin filament capping (GO:0051016)4.05772193
10muscle cell migration (GO:0014812)4.05337002
11chondrocyte proliferation (GO:0035988)4.04094469
12fibroblast migration (GO:0010761)4.02549319
13positive regulation of actin filament depolymerization (GO:0030836)3.97923311
14sequestering of extracellular ligand from receptor (GO:0035581)3.96216821
15negative regulation of stem cell proliferation (GO:2000647)3.89884022
16protein heterotetramerization (GO:0051290)3.86665707
17regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.80408870
18protein localization to cell surface (GO:0034394)3.80265946
19substrate-dependent cell migration (GO:0006929)3.73401111
20cell adhesion mediated by integrin (GO:0033627)3.70293701
21negative regulation of axon extension involved in axon guidance (GO:0048843)3.65210104
22coenzyme catabolic process (GO:0009109)3.64702007
23UDP-N-acetylglucosamine metabolic process (GO:0006047)3.60367692
24regulation of mitotic spindle organization (GO:0060236)3.58944099
25membrane raft organization (GO:0031579)3.51068233
26peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.50650848
27fibril organization (GO:0097435)3.49307914
28extracellular fibril organization (GO:0043206)3.37162969
29regulation of integrin-mediated signaling pathway (GO:2001044)3.34156253
30glomerular visceral epithelial cell development (GO:0072015)3.33407689
31L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.31411140
32arginine catabolic process (GO:0006527)3.28025709
33membrane assembly (GO:0071709)3.22661556
34mesodermal cell differentiation (GO:0048333)3.22658030
35actin filament depolymerization (GO:0030042)3.19504268
36mesenchymal cell proliferation (GO:0010463)3.17321428
37ganglion development (GO:0061548)3.16218725
38negative regulation of axon guidance (GO:1902668)3.16136952
39AMP metabolic process (GO:0046033)3.10550546
40COPII vesicle coating (GO:0048208)3.09459309
41organ induction (GO:0001759)3.08697489
42collagen fibril organization (GO:0030199)3.01300668
43metaphase plate congression (GO:0051310)2.96579722
44negative regulation of complement activation (GO:0045916)2.95302789
45type B pancreatic cell proliferation (GO:0044342)2.95064041
46branch elongation of an epithelium (GO:0060602)2.94368409
47negative regulation of chondrocyte differentiation (GO:0032331)2.94253460
48substrate adhesion-dependent cell spreading (GO:0034446)2.94058705
49negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.93854296
50cellular response to interferon-alpha (GO:0035457)2.93008200
51smooth muscle tissue development (GO:0048745)2.92579937
52glucosamine-containing compound catabolic process (GO:1901072)2.91837143
53ribosome assembly (GO:0042255)2.90891711
54facial nerve structural organization (GO:0021612)2.88915331
55myoblast migration (GO:0051451)2.87670493
56regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.86160666
57cranial nerve morphogenesis (GO:0021602)2.85027384
58response to gravity (GO:0009629)2.84277331
59relaxation of smooth muscle (GO:0044557)2.82932539
60glomerular epithelial cell development (GO:0072310)2.80299973
61wound healing, spreading of epidermal cells (GO:0035313)2.77267097
62nucleotide-sugar biosynthetic process (GO:0009226)2.73425768
63protein hydroxylation (GO:0018126)2.70489686
64positive regulation of interleukin-8 secretion (GO:2000484)2.70257475
65sprouting angiogenesis (GO:0002040)2.68253285
66negative regulation of striated muscle cell apoptotic process (GO:0010664)2.67117710
67SMAD protein complex assembly (GO:0007183)2.66379127
68positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.64965956
69mitotic metaphase plate congression (GO:0007080)2.61438524
70endocardial cushion development (GO:0003197)2.60002558
71response to increased oxygen levels (GO:0036296)2.58785438
72response to hyperoxia (GO:0055093)2.58785438
73positive regulation of protein autophosphorylation (GO:0031954)2.57888633
74regulation of extracellular matrix disassembly (GO:0010715)2.56716605
75regulation of spindle organization (GO:0090224)2.56590725
76metanephric mesenchyme development (GO:0072075)2.56283751
77muscle organ morphogenesis (GO:0048644)2.54616769
78vascular endothelial growth factor signaling pathway (GO:0038084)2.53565356
79establishment of chromosome localization (GO:0051303)2.52562107
80extracellular regulation of signal transduction (GO:1900115)2.52330312
81extracellular negative regulation of signal transduction (GO:1900116)2.52330312
82dermatan sulfate biosynthetic process (GO:0030208)2.50912892
83lipopolysaccharide biosynthetic process (GO:0009103)2.50301570
84kidney mesenchyme development (GO:0072074)2.49191521
85negative regulation of protein activation cascade (GO:2000258)2.48477254
86ventricular cardiac muscle cell development (GO:0055015)2.48435418
87positive regulation of smooth muscle cell migration (GO:0014911)2.47149433
88endosome to pigment granule transport (GO:0043485)2.43697089
89endosome to melanosome transport (GO:0035646)2.43697089
90negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.43650885
91oligosaccharide biosynthetic process (GO:0009312)2.43421658
92lymphangiogenesis (GO:0001946)2.42811646
93L-methionine salvage (GO:0071267)2.42216444
94L-methionine biosynthetic process (GO:0071265)2.42216444
95amino acid salvage (GO:0043102)2.42216444
96regulation of chemokine-mediated signaling pathway (GO:0070099)2.38082554
97dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.34173121
98regulation of sulfur metabolic process (GO:0042762)2.32851870
99cellular response to vitamin D (GO:0071305)2.32784121
100neural crest cell development (GO:0014032)2.32749922

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SMAD_19615063_ChIP-ChIP_OVARY_Human5.26950970
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.66034296
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.97598376
4GBX2_23144817_ChIP-Seq_PC3_Human3.92485260
5SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.16488989
6BRD4_25478319_ChIP-Seq_HGPS_Human3.04524876
7CEBPD_23245923_ChIP-Seq_MEFs_Mouse3.01378803
8CJUN_26792858_Chip-Seq_BT549_Human2.98987120
9PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.75626949
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.71102277
11CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.55683955
12WT1_19549856_ChIP-ChIP_CCG9911_Human2.51426139
13AR_21909140_ChIP-Seq_LNCAP_Human2.35901291
14BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.28922683
15EP300_21415370_ChIP-Seq_HL-1_Mouse2.28843012
16ELK1_19687146_ChIP-ChIP_HELA_Human2.28001151
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.21152280
18TP53_18474530_ChIP-ChIP_U2OS_Human2.12880369
19TP53_16413492_ChIP-PET_HCT116_Human2.09687415
20ZFP57_27257070_Chip-Seq_ESCs_Mouse2.08171331
21HIF1A_21447827_ChIP-Seq_MCF-7_Human2.04473387
22E2F7_22180533_ChIP-Seq_HELA_Human2.00258133
23NRF2_20460467_ChIP-Seq_MEFs_Mouse1.94919651
24NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.94919651
25AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.94570654
26JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.89539976
27SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.88439043
28SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.88439043
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.85149184
30JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.84770730
31CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.83819642
32SALL1_21062744_ChIP-ChIP_HESCs_Human1.76018870
33POU3F2_20337985_ChIP-ChIP_501MEL_Human1.75523625
34FOXM1_23109430_ChIP-Seq_U2OS_Human1.74772238
35P300_19829295_ChIP-Seq_ESCs_Human1.67102989
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.66475426
37SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.64666828
38ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.60768040
39SMAD4_21799915_ChIP-Seq_A2780_Human1.60435394
40ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.56963448
41MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.55241790
42FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.54831873
43FUS_26573619_Chip-Seq_HEK293_Human1.54753603
44ESR1_20079471_ChIP-ChIP_T-47D_Human1.52912444
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.51832793
46SALL4_18804426_ChIP-ChIP_XEN_Mouse1.49244406
47ZNF217_24962896_ChIP-Seq_MCF-7_Human1.48375249
48ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.45513041
49OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43763086
50GATA2_21666600_ChIP-Seq_HMVEC_Human1.43660874
51TAF15_26573619_Chip-Seq_HEK293_Human1.40532189
52FOXM1_26456572_ChIP-Seq_MCF-7_Human1.38926340
53EWS_26573619_Chip-Seq_HEK293_Human1.37678110
54TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.37590508
55AR_21572438_ChIP-Seq_LNCaP_Human1.31301760
56AHR_22903824_ChIP-Seq_MCF-7_Human1.31003532
57* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27748731
58PPAR_26484153_Chip-Seq_NCI-H1993_Human1.27079201
59FLI1_27457419_Chip-Seq_LIVER_Mouse1.26346389
60CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.25144218
61CTBP1_25329375_ChIP-Seq_LNCAP_Human1.24372107
62KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.21632338
63STAT3_23295773_ChIP-Seq_U87_Human1.21499481
64ER_23166858_ChIP-Seq_MCF-7_Human1.20659562
65CTNNB1_20460455_ChIP-Seq_HCT116_Human1.20045374
66ELK1_22589737_ChIP-Seq_MCF10A_Human1.19261462
67CBP_21632823_ChIP-Seq_H3396_Human1.18356554
68CDX2_22108803_ChIP-Seq_LS180_Human1.17350689
69IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14717050
70CBP_20019798_ChIP-Seq_JUKART_Human1.14717050
71FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.14426496
72CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13290385
73GABP_17652178_ChIP-ChIP_JURKAT_Human1.13111253
74FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.11860554
75ARNT_22903824_ChIP-Seq_MCF-7_Human1.11762644
76CTBP2_25329375_ChIP-Seq_LNCAP_Human1.11447147
77RXR_22108803_ChIP-Seq_LS180_Human1.09134849
78NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08790550
79SOX9_26525672_Chip-Seq_HEART_Mouse1.06940530
80RARG_19884340_ChIP-ChIP_MEFs_Mouse1.04765700
81KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04061743
82PADI4_21655091_ChIP-ChIP_MCF-7_Human1.03689687
83SOX2_20726797_ChIP-Seq_SW620_Human1.03070175
84SOX17_20123909_ChIP-Seq_XEN_Mouse1.00271846
85HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.99885006
86SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99192059
87VDR_22108803_ChIP-Seq_LS180_Human0.98206813
88HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.98147719
89RBPJ_22232070_ChIP-Seq_NCS_Mouse0.97844937
90MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97310150
91RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.95305896
92TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.94936856
93TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94737444
94SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.94535820
95PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.93079660
96UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91947458
97EZH2_27294783_Chip-Seq_NPCs_Mouse0.91154244
98TOP2B_26459242_ChIP-Seq_MCF-7_Human0.90933090
99NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.90558643
100KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.90177229

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.69271442
2MP0003950_abnormal_plasma_membrane4.62758261
3MP0009697_abnormal_copulation3.83464546
4MP0004272_abnormal_basement_membrane3.64322800
5MP0005275_abnormal_skin_tensile3.49870047
6MP0009780_abnormal_chondrocyte_physiolo2.89183379
7MP0001299_abnormal_eye_distance/2.86946965
8MP0005257_abnormal_intraocular_pressure2.66138590
9MP0005171_absent_coat_pigmentation2.59327129
10MP0005503_abnormal_tendon_morphology2.56911242
11MP0010368_abnormal_lymphatic_system2.49900390
12MP0006054_spinal_hemorrhage2.22388454
13MP0000749_muscle_degeneration2.21706993
14MP0005623_abnormal_meninges_morphology2.19440754
15MP0000751_myopathy2.07161351
16MP0000569_abnormal_digit_pigmentation2.06881563
17MP0001958_emphysema1.96949434
18MP0003385_abnormal_body_wall1.82720617
19MP0003279_aneurysm1.82159031
20MP0010352_gastrointestinal_tract_polyps1.79250523
21MP0005023_abnormal_wound_healing1.76171132
22MP0000767_abnormal_smooth_muscle1.75712646
23MP0003091_abnormal_cell_migration1.66643459
24MP0004084_abnormal_cardiac_muscle1.64139785
25MP0001661_extended_life_span1.63390811
26MP0003566_abnormal_cell_adhesion1.62580576
27MP0000762_abnormal_tongue_morphology1.57521618
28MP0010386_abnormal_urinary_bladder1.55604437
29MP0000534_abnormal_ureter_morphology1.51638750
30MP0000013_abnormal_adipose_tissue1.40474369
31MP0009250_abnormal_appendicular_skeleto1.39003191
32MP0002295_abnormal_pulmonary_circulatio1.35839795
33MP0010030_abnormal_orbit_morphology1.35326262
34MP0008775_abnormal_heart_ventricle1.32303685
35MP0000427_abnormal_hair_cycle1.31256639
36MP0001529_abnormal_vocalization1.27109973
37MP0005165_increased_susceptibility_to1.26118162
38MP0002282_abnormal_trachea_morphology1.25080356
39MP0005508_abnormal_skeleton_morphology1.23191209
40MP0002160_abnormal_reproductive_system1.20981119
41MP0003937_abnormal_limbs/digits/tail_de1.18249316
42MP0008004_abnormal_stomach_pH1.16490193
43MP0003806_abnormal_nucleotide_metabolis1.15706235
44MP0000538_abnormal_urinary_bladder1.14887543
45MP0002233_abnormal_nose_morphology1.13800375
46MP0001879_abnormal_lymphatic_vessel1.13467132
47MP0003705_abnormal_hypodermis_morpholog1.13362176
48MP0005595_abnormal_vascular_smooth1.12730323
49MP0002060_abnormal_skin_morphology1.12520225
50MP0003942_abnormal_urinary_system1.12199672
51MP0002127_abnormal_cardiovascular_syste1.10075746
52MP0006072_abnormal_retinal_apoptosis1.09821807
53MP0003755_abnormal_palate_morphology1.06604672
54MP0002177_abnormal_outer_ear1.02209265
55MP0000516_abnormal_urinary_system1.01053124
56MP0005367_renal/urinary_system_phenotyp1.01053124
57MP0003941_abnormal_skin_development1.00948775
58MP0005253_abnormal_eye_physiology0.99134970
59MP0005197_abnormal_uvea_morphology0.97461907
60MP0004134_abnormal_chest_morphology0.96773563
61MP0002168_other_aberrant_phenotype0.92227432
62MP0000163_abnormal_cartilage_morphology0.92075241
63MP0001542_abnormal_bone_strength0.91505302
64MP0001243_abnormal_dermal_layer0.89708101
65MP0003191_abnormal_cellular_cholesterol0.88940336
66MP0003936_abnormal_reproductive_system0.88427904
67MP0003935_abnormal_craniofacial_develop0.87919198
68MP0002108_abnormal_muscle_morphology0.86623202
69MP0005193_abnormal_anterior_eye0.86128761
70MP0000750_abnormal_muscle_regeneration0.86108571
71MP0008932_abnormal_embryonic_tissue0.84034958
72MP0002938_white_spotting0.83503592
73MP0000733_abnormal_muscle_development0.82318293
74MP0000759_abnormal_skeletal_muscle0.81876394
75MP0004036_abnormal_muscle_relaxation0.81305199
76MP0009053_abnormal_anal_canal0.81273134
77MP0010678_abnormal_skin_adnexa0.79094060
78MP0004233_abnormal_muscle_weight0.78787734
79MP0005391_vision/eye_phenotype0.78150491
80MP0002332_abnormal_exercise_endurance0.78081900
81MP0001293_anophthalmia0.76027349
82MP0000647_abnormal_sebaceous_gland0.75963617
83MP0000432_abnormal_head_morphology0.75337663
84MP0005164_abnormal_response_to0.74735314
85MP0002896_abnormal_bone_mineralization0.72580578
86MP0008007_abnormal_cellular_replicative0.70239347
87MP0010234_abnormal_vibrissa_follicle0.68369553
88MP0003868_abnormal_feces_composition0.68055336
89MP0000627_abnormal_mammary_gland0.68021925
90MP0001340_abnormal_eyelid_morphology0.67686748
91MP0005084_abnormal_gallbladder_morpholo0.67602541
92MP0003252_abnormal_bile_duct0.67430966
93MP0005395_other_phenotype0.66736401
94MP0000747_muscle_weakness0.66656618
95MP0000003_abnormal_adipose_tissue0.66595621
96MP0002269_muscular_atrophy0.66549502
97MP0005620_abnormal_muscle_contractility0.64971850
98MP0002128_abnormal_blood_circulation0.64368996
99MP0003828_pulmonary_edema0.63769058
100MP0002115_abnormal_skeleton_extremities0.63355676

Predicted human phenotypes

RankGene SetZ-score
1Follicular hyperkeratosis (HP:0007502)4.62311851
2Premature rupture of membranes (HP:0001788)4.55739324
3Spinal cord lesions (HP:0100561)4.19106606
4Syringomyelia (HP:0003396)4.19106606
5Aortic aneurysm (HP:0004942)4.17200595
6Sensory axonal neuropathy (HP:0003390)3.96025621
7Entropion (HP:0000621)3.76158777
8Osteolytic defects of the hand bones (HP:0009699)3.74299336
9Osteolytic defects of the phalanges of the hand (HP:0009771)3.74299336
10Microglossia (HP:0000171)3.73188208
11Aortic dissection (HP:0002647)3.54544243
12Short nail (HP:0001799)3.53481361
13Cervical subluxation (HP:0003308)3.49887517
14Reduced subcutaneous adipose tissue (HP:0003758)3.35822210
15Upper limb muscle weakness (HP:0003484)3.20102890
16Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)3.09587283
17Mitral stenosis (HP:0001718)2.98454826
18Spinal rigidity (HP:0003306)2.95496551
19Abnormality of the intrinsic pathway (HP:0010989)2.91969896
20Protrusio acetabuli (HP:0003179)2.88628481
21Cardiovascular calcification (HP:0011915)2.82330783
22Delayed gross motor development (HP:0002194)2.74176651
23Abnormal auditory evoked potentials (HP:0006958)2.70342831
24Aplasia/Hypoplasia of the tongue (HP:0010295)2.68941822
25Hyporeflexia of lower limbs (HP:0002600)2.68247159
26Adrenal hypoplasia (HP:0000835)2.60629769
27Ileus (HP:0002595)2.60176239
28Bifid tongue (HP:0010297)2.59558265
29Arterial tortuosity (HP:0005116)2.52076952
30Soft skin (HP:0000977)2.50001314
31Increased number of teeth (HP:0011069)2.47528367
32Spondylolisthesis (HP:0003302)2.42623656
33Short clavicles (HP:0000894)2.41678889
34Vascular tortuosity (HP:0004948)2.40768766
35Hypoplastic pelvis (HP:0008839)2.35526103
36Abnormality of the frontal sinuses (HP:0002687)2.28917687
37Tubulointerstitial nephritis (HP:0001970)2.27596781
38Facial diplegia (HP:0001349)2.25371408
39Hypoplasia of the iris (HP:0007676)2.21354703
40Short humerus (HP:0005792)2.20317645
41Atrophic scars (HP:0001075)2.19596664
42Fibular aplasia (HP:0002990)2.19054694
43Aplasia/hypoplasia of the humerus (HP:0006507)2.17921218
44Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.17307911
45Exercise-induced muscle cramps (HP:0003710)2.15120205
46Abnormality of carpal bone ossification (HP:0006257)2.12584128
47True hermaphroditism (HP:0010459)2.11271340
48Aplasia/Hypoplasia of the clavicles (HP:0006710)2.10722418
49Reduced antithrombin III activity (HP:0001976)2.10123760
50Central scotoma (HP:0000603)2.07632245
51Abnormal hand bone ossification (HP:0010660)2.07594319
52Short tibia (HP:0005736)2.06372951
53Supernumerary spleens (HP:0009799)2.05993713
54Capillary hemangiomas (HP:0005306)2.03873060
55Vascular calcification (HP:0004934)2.03828027
56Aplasia/Hypoplasia of the tibia (HP:0005772)2.02918319
57Abnormality of the anterior chamber (HP:0000593)2.01951028
58Glucose intolerance (HP:0000833)2.00126834
59Abnormality of dentin (HP:0010299)1.99687465
60Pulmonic stenosis (HP:0001642)1.95531382
61Decreased skull ossification (HP:0004331)1.94693897
62Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.94192151
63Spinal cord compression (HP:0002176)1.94148975
64Knee flexion contracture (HP:0006380)1.91745538
65Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.90510460
66Delayed closure of the anterior fontanelle (HP:0001476)1.90064223
67Natal tooth (HP:0000695)1.89865732
68White forelock (HP:0002211)1.89789412
69Elbow flexion contracture (HP:0002987)1.87727656
70Papilledema (HP:0001085)1.87579695
71Limb-girdle muscle atrophy (HP:0003797)1.86511826
72Poor head control (HP:0002421)1.86073037
73Bradycardia (HP:0001662)1.85446196
74Patchy hypopigmentation of hair (HP:0011365)1.84290692
75Abnormality of the shoulder girdle musculature (HP:0001435)1.83325266
76Abnormality of the phalanges of the hallux (HP:0010057)1.82716857
77Poikiloderma (HP:0001029)1.81773727
78Postaxial foot polydactyly (HP:0001830)1.81445697
79Lipoatrophy (HP:0100578)1.80922421
80Relative macrocephaly (HP:0004482)1.79649024
81Coronal craniosynostosis (HP:0004440)1.75315064
82Sclerocornea (HP:0000647)1.74378878
83Pulmonary artery stenosis (HP:0004415)1.74151765
84Hypoplastic scapulae (HP:0000882)1.73826611
85Aplasia/Hypoplasia of the scapulae (HP:0006713)1.73826611
86Aortic regurgitation (HP:0001659)1.73799068
87Neonatal short-limb short stature (HP:0008921)1.73482307
88Dental crowding (HP:0000678)1.73050887
89Broad face (HP:0000283)1.73030319
90Aplasia/Hypoplasia of the fibula (HP:0006492)1.69870942
91Wormian bones (HP:0002645)1.67790592
92Abnormality of the distal phalanges of the toes (HP:0010182)1.67527887
93Decreased lacrimation (HP:0000633)1.67069700
94Abnormal ossification of hand bones (HP:0005921)1.64538404
95Scanning speech (HP:0002168)1.64256049
96Abnormality of the calf musculature (HP:0001430)1.60775763
97Deviation of the thumb (HP:0009603)1.60656541
98Pancreatic fibrosis (HP:0100732)1.58331292
99Bell-shaped thorax (HP:0001591)1.56523348
100Abnormality of methionine metabolism (HP:0010901)1.55845520

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R4.16200532
2MYLK3.04370235
3LATS12.79466352
4LIMK12.74001786
5STK38L2.69250670
6MAP2K72.41819641
7FRK2.37008177
8MET2.26571097
9DDR22.25020196
10EIF2AK32.09397196
11TESK12.05532349
12NEK22.03547154
13NEK92.01882093
14MOS1.94825882
15NEK11.88476883
16EPHB11.78338723
17ERBB41.77387400
18NME21.75211927
19MAP3K121.68438603
20STK381.66672209
21BMPR1B1.65665412
22PINK11.59197026
23AKT31.57866190
24BCR1.56590084
25ERBB31.56045505
26LATS21.51998791
27PLK21.50970790
28CDK81.47427396
29PBK1.46783374
30STK101.44426483
31TGFBR21.37584817
32LMTK21.33403034
33SCYL21.30642868
34PDGFRA1.28592268
35EIF2AK11.26858284
36PAK21.26768806
37MST41.25699871
38EPHA21.24195295
39CSNK1A1L1.24107259
40SRPK11.19512659
41STK391.13718868
42STK31.13022716
43ROCK11.12403598
44PAK61.10922601
45ABL21.04247073
46PTK21.02751906
47PDK20.95989398
48PLK30.92401306
49MAP4K20.92000640
50FLT30.91415680
51PTK2B0.88888765
52BUB10.87393820
53PAK40.87082265
54PDGFRB0.86712772
55ROCK20.85977757
56ILK0.85914626
57BRSK10.85185279
58PAK30.81619200
59TRPM70.81066437
60MAPKAPK50.80163355
61CLK10.80142318
62OBSCN0.79802142
63CSNK1G30.78167965
64ARAF0.77970465
65NUAK10.77747349
66MELK0.76219134
67CCNB10.75177152
68AURKB0.74202550
69CDC70.71249077
70VRK20.70085970
71PAK10.69673464
72CSNK1G20.69000170
73CSNK1G10.63911630
74MARK30.63907048
75MKNK20.61540163
76RAF10.60343383
77GRK70.59138668
78CAMK2D0.58433057
79TIE10.57957331
80ADRBK10.57531064
81PIM20.57135826
82PLK10.54523505
83MAP3K40.53214103
84PRKCE0.52300529
85FGFR10.52292252
86MKNK10.47248409
87RIPK10.45517964
88TGFBR10.44017266
89BRSK20.40685202
90FER0.40057116
91MAP3K20.39421852
92CAMKK20.38765144
93GSK3A0.38025518
94CAMK2G0.37802681
95VRK10.37773017
96ATM0.35843401
97DAPK30.33470313
98PRKD20.33133427
99EPHA40.31801413
100BMPR20.31353019

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.94089786
2Steroid biosynthesis_Homo sapiens_hsa001002.83727336
3ECM-receptor interaction_Homo sapiens_hsa045122.45831680
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.25291450
5Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.25127238
6Nucleotide excision repair_Homo sapiens_hsa034202.11562786
7DNA replication_Homo sapiens_hsa030302.04311821
8Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.97617924
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.91572534
10Olfactory transduction_Homo sapiens_hsa047401.84148178
11Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.83870567
12TGF-beta signaling pathway_Homo sapiens_hsa043501.83252461
13Focal adhesion_Homo sapiens_hsa045101.78282939
14Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.78107349
15Propanoate metabolism_Homo sapiens_hsa006401.77416226
16Hedgehog signaling pathway_Homo sapiens_hsa043401.68814044
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.68703526
18Adherens junction_Homo sapiens_hsa045201.65805409
19Proteasome_Homo sapiens_hsa030501.65098090
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.63901976
21Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.60759571
22Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.59268890
23Fanconi anemia pathway_Homo sapiens_hsa034601.51942120
24Hippo signaling pathway_Homo sapiens_hsa043901.50699454
25Pyruvate metabolism_Homo sapiens_hsa006201.50217294
26Cysteine and methionine metabolism_Homo sapiens_hsa002701.47913575
27Dilated cardiomyopathy_Homo sapiens_hsa054141.45855648
28Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.42867399
29Non-homologous end-joining_Homo sapiens_hsa034501.42035804
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.40473013
31Melanoma_Homo sapiens_hsa052181.40246017
32Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.39232655
33Proteoglycans in cancer_Homo sapiens_hsa052051.38934779
34Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.34953430
35Glutathione metabolism_Homo sapiens_hsa004801.33963291
36Pyrimidine metabolism_Homo sapiens_hsa002401.31305820
37Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.24340021
38One carbon pool by folate_Homo sapiens_hsa006701.24321400
39Biosynthesis of amino acids_Homo sapiens_hsa012301.22910920
40Regulation of actin cytoskeleton_Homo sapiens_hsa048101.22738624
41N-Glycan biosynthesis_Homo sapiens_hsa005101.16046464
42Circadian rhythm_Homo sapiens_hsa047101.14672215
43Basal cell carcinoma_Homo sapiens_hsa052171.12184472
44Mismatch repair_Homo sapiens_hsa034301.09555233
45beta-Alanine metabolism_Homo sapiens_hsa004101.08889949
46Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.07330372
47Vibrio cholerae infection_Homo sapiens_hsa051101.06652932
48Homologous recombination_Homo sapiens_hsa034401.02733852
49Purine metabolism_Homo sapiens_hsa002301.02206231
50Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.98593451
51Vitamin B6 metabolism_Homo sapiens_hsa007500.94789813
52Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.93737093
53SNARE interactions in vesicular transport_Homo sapiens_hsa041300.93456543
54Salivary secretion_Homo sapiens_hsa049700.93353033
55Folate biosynthesis_Homo sapiens_hsa007900.92540476
56PI3K-Akt signaling pathway_Homo sapiens_hsa041510.92455040
57Wnt signaling pathway_Homo sapiens_hsa043100.92033547
58RNA polymerase_Homo sapiens_hsa030200.91070706
59p53 signaling pathway_Homo sapiens_hsa041150.84877140
60Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.80578060
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.79819634
62MicroRNAs in cancer_Homo sapiens_hsa052060.79233195
63Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.76218929
64Protein export_Homo sapiens_hsa030600.76183154
65Steroid hormone biosynthesis_Homo sapiens_hsa001400.75183109
66Base excision repair_Homo sapiens_hsa034100.74008811
67Basal transcription factors_Homo sapiens_hsa030220.73033292
68Small cell lung cancer_Homo sapiens_hsa052220.72563420
69Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.71372707
70Gap junction_Homo sapiens_hsa045400.70139389
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69735277
72Chemical carcinogenesis_Homo sapiens_hsa052040.67979440
73Complement and coagulation cascades_Homo sapiens_hsa046100.66757820
74Tight junction_Homo sapiens_hsa045300.64713634
75Pentose phosphate pathway_Homo sapiens_hsa000300.64144256
76Arginine and proline metabolism_Homo sapiens_hsa003300.63988788
77Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.63869680
78Primary bile acid biosynthesis_Homo sapiens_hsa001200.61886601
79Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60940831
80Tyrosine metabolism_Homo sapiens_hsa003500.58547163
81Pathways in cancer_Homo sapiens_hsa052000.57882586
82Butanoate metabolism_Homo sapiens_hsa006500.57672900
83Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.57188704
84Axon guidance_Homo sapiens_hsa043600.55461276
85Sulfur relay system_Homo sapiens_hsa041220.54261321
86Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.53501648
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49498127
88Metabolic pathways_Homo sapiens_hsa011000.48324773
89Carbon metabolism_Homo sapiens_hsa012000.48138777
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.46620430
91Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46261137
92Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.46010248
93Histidine metabolism_Homo sapiens_hsa003400.45679365
94Oocyte meiosis_Homo sapiens_hsa041140.44396036
95Melanogenesis_Homo sapiens_hsa049160.43769678
96Cell cycle_Homo sapiens_hsa041100.42879059
97Selenocompound metabolism_Homo sapiens_hsa004500.41161798
98Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.40715532
99Mineral absorption_Homo sapiens_hsa049780.38930106
100Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.34173465

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