BLCAP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that reduces cell growth by stimulating apoptosis. Alternative splicing and the use of alternative promoters result in multiple transcript variants encoding the same protein. This gene is imprinted in brain where different transcript variants are expressed from each parental allele. Transcript variants initiating from the upstream promoter are expressed preferentially from the maternal allele, while transcript variants initiating downstream of the interspersed NNAT gene (GeneID:4826) are expressed from the paternal allele. Transcripts at this locus may also undergo A to I editing, resulting in amino acid changes at three positions in the N-terminus of the protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.13745664
2synaptic vesicle exocytosis (GO:0016079)4.95786912
3establishment of mitochondrion localization (GO:0051654)4.86934501
4vocalization behavior (GO:0071625)4.76571465
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.66873153
6neuron cell-cell adhesion (GO:0007158)4.40979584
7synaptic vesicle maturation (GO:0016188)4.39248889
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.34521132
9regulation of synaptic vesicle exocytosis (GO:2000300)4.33238165
10positive regulation of mitochondrial fission (GO:0090141)4.33080787
11glutamate secretion (GO:0014047)4.20751580
12proline transport (GO:0015824)4.17943038
13regulation of glutamate receptor signaling pathway (GO:1900449)4.15399147
14locomotory exploration behavior (GO:0035641)4.14441778
15protein localization to synapse (GO:0035418)4.05862479
16positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.98837362
17neurotransmitter secretion (GO:0007269)3.95076419
18regulation of synaptic vesicle transport (GO:1902803)3.92730839
19regulation of cAMP-dependent protein kinase activity (GO:2000479)3.86064267
20synaptic vesicle docking involved in exocytosis (GO:0016081)3.86056915
21regulation of synapse structural plasticity (GO:0051823)3.79975567
22synaptic vesicle endocytosis (GO:0048488)3.76738064
23neuromuscular process controlling posture (GO:0050884)3.76715212
24ionotropic glutamate receptor signaling pathway (GO:0035235)3.68185077
25positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.66769273
26presynaptic membrane assembly (GO:0097105)3.66182017
27exploration behavior (GO:0035640)3.66100967
28layer formation in cerebral cortex (GO:0021819)3.64276809
29activation of protein kinase A activity (GO:0034199)3.56675846
30regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.56450074
31neuron recognition (GO:0008038)3.55282805
32response to pheromone (GO:0019236)3.51010959
33glutamate receptor signaling pathway (GO:0007215)3.46305780
34gamma-aminobutyric acid transport (GO:0015812)3.40934215
35mitochondrion transport along microtubule (GO:0047497)3.39713178
36establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.39713178
37neurotransmitter-gated ion channel clustering (GO:0072578)3.38802935
38calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.37067950
39pyrimidine nucleobase catabolic process (GO:0006208)3.36992943
40positive regulation of synaptic transmission, GABAergic (GO:0032230)3.36939485
41neuron-neuron synaptic transmission (GO:0007270)3.36528901
42regulation of neuronal synaptic plasticity (GO:0048168)3.35935524
43synaptic transmission, glutamatergic (GO:0035249)3.33564617
44glycosphingolipid biosynthetic process (GO:0006688)3.33193135
45presynaptic membrane organization (GO:0097090)3.30532979
46cell migration in hindbrain (GO:0021535)3.26696271
47regulation of long-term neuronal synaptic plasticity (GO:0048169)3.26471916
48axonal fasciculation (GO:0007413)3.25611671
49regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.25273432
50cell communication by electrical coupling (GO:0010644)3.24206748
51neurotransmitter transport (GO:0006836)3.22550278
52membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.22155912
53auditory behavior (GO:0031223)3.17165990
54striatum development (GO:0021756)3.17046721
55behavioral response to nicotine (GO:0035095)3.16639640
56neurofilament cytoskeleton organization (GO:0060052)3.15621225
57neuronal action potential propagation (GO:0019227)3.15571831
58response to auditory stimulus (GO:0010996)3.15336575
59mating behavior (GO:0007617)3.15298166
60dendritic spine morphogenesis (GO:0060997)3.14098761
61cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.13072373
62innervation (GO:0060384)3.12307996
63dendritic spine organization (GO:0097061)3.10844221
64negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.07553394
65regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.05864095
66organelle transport along microtubule (GO:0072384)3.05792142
67protein localization to cilium (GO:0061512)3.05727205
68regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.05587500
69neuronal ion channel clustering (GO:0045161)3.05148892
70response to histamine (GO:0034776)3.04305748
71positive regulation of synapse maturation (GO:0090129)3.04234854
72establishment of synaptic vesicle localization (GO:0097480)3.02402117
73synaptic vesicle transport (GO:0048489)3.02402117
74gamma-aminobutyric acid signaling pathway (GO:0007214)3.01466662
75regulation of neurotransmitter levels (GO:0001505)3.00148775
76negative regulation of synaptic transmission, GABAergic (GO:0032229)2.98332175
77regulation of synaptic transmission, dopaminergic (GO:0032225)2.98048151
78cerebellar Purkinje cell layer development (GO:0021680)2.97738471
79regulation of synaptic transmission, glutamatergic (GO:0051966)2.97063351
80regulation of excitatory postsynaptic membrane potential (GO:0060079)2.97051759
81neuromuscular synaptic transmission (GO:0007274)2.94818764
82regulation of mitochondrial fission (GO:0090140)2.92039303
83protein insertion into membrane (GO:0051205)2.91997032
84long-term synaptic potentiation (GO:0060291)2.90671383
85central nervous system projection neuron axonogenesis (GO:0021952)2.90013925
86regulation of postsynaptic membrane potential (GO:0060078)2.89034900
87nucleobase catabolic process (GO:0046113)2.88364774
88dopamine receptor signaling pathway (GO:0007212)2.86936184
89G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.85999251
90prepulse inhibition (GO:0060134)2.85930117
91regulation of vesicle fusion (GO:0031338)2.85445774
92synapse assembly (GO:0007416)2.85245285
93postsynaptic membrane organization (GO:0001941)2.85165013
94cellular potassium ion homeostasis (GO:0030007)2.82917339
95detection of calcium ion (GO:0005513)2.82743912
96energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.82690981
97ATP hydrolysis coupled proton transport (GO:0015991)2.82690981
98long-term memory (GO:0007616)2.82454789
99dendrite morphogenesis (GO:0048813)2.82413223
100regulation of glutamate secretion (GO:0014048)2.81570896
101ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.81485573
102alanine transport (GO:0032328)2.81437635
103regulation of neurotransmitter secretion (GO:0046928)2.80542696
104positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.80382428
105hippocampus development (GO:0021766)2.78079142
106regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.76247906
107regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.76247906
108establishment of vesicle localization (GO:0051650)2.75415218
109positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.75331783
110positive regulation of synapse assembly (GO:0051965)2.74818437
111regulation of dendritic spine morphogenesis (GO:0061001)2.73959744
112axon extension (GO:0048675)2.72939313
113vesicle transport along microtubule (GO:0047496)2.72716534
114negative regulation of microtubule polymerization (GO:0031115)2.72713474
115transmission of nerve impulse (GO:0019226)2.72676038
116nonmotile primary cilium assembly (GO:0035058)2.72553690
117behavioral fear response (GO:0001662)2.72150244
118behavioral defense response (GO:0002209)2.72150244
119regulation of neurotransmitter transport (GO:0051588)2.71957215
120regulation of respiratory system process (GO:0044065)2.71330178
121synapse organization (GO:0050808)2.71253663
122neuromuscular process controlling balance (GO:0050885)2.71047897
123acidic amino acid transport (GO:0015800)2.69969120
124positive regulation of membrane potential (GO:0045838)2.69419774
125response to dietary excess (GO:0002021)2.68789423
126regulation of synaptic plasticity (GO:0048167)2.68447626
127behavioral response to cocaine (GO:0048148)2.68179215
128regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.68132350
129ubiquinone metabolic process (GO:0006743)2.64423917
130establishment of melanosome localization (GO:0032401)2.63993637
131regulation of synapse assembly (GO:0051963)2.63004496
132adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.60819923
133regulation of synapse maturation (GO:0090128)2.59527977
134synaptic transmission, cholinergic (GO:0007271)2.56659752
135protein polyglutamylation (GO:0018095)2.55735184
136retinal ganglion cell axon guidance (GO:0031290)2.54232653
137neurotransmitter biosynthetic process (GO:0042136)2.53267401
138neuron projection extension (GO:1990138)2.53129468
139establishment of pigment granule localization (GO:0051905)2.52377118
140epithelial cell differentiation involved in kidney development (GO:0035850)2.52215622
141vesicle localization (GO:0051648)2.51261280
142neuronal action potential (GO:0019228)2.50022778
143regulation of feeding behavior (GO:0060259)2.49525972
144cytoskeleton-dependent intracellular transport (GO:0030705)2.48164532
145startle response (GO:0001964)2.47918898
146substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.47627100

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.59630015
2GBX2_23144817_ChIP-Seq_PC3_Human3.27426784
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.02963620
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.96521449
5CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.75617335
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.75168200
7REST_21632747_ChIP-Seq_MESCs_Mouse2.74108369
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.61405995
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.57814537
10NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.52892326
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.51389795
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.51389795
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.50639070
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.44689876
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.44229835
16* REST_18959480_ChIP-ChIP_MESCs_Mouse2.42004935
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.40599754
18MTF2_20144788_ChIP-Seq_MESCs_Mouse2.40311345
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.27907371
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.19690549
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.18067720
22EED_16625203_ChIP-ChIP_MESCs_Mouse2.17731508
23RARB_27405468_Chip-Seq_BRAIN_Mouse2.14985639
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.11551595
25CTBP2_25329375_ChIP-Seq_LNCAP_Human2.07436851
26DROSHA_22980978_ChIP-Seq_HELA_Human1.97189063
27ERG_21242973_ChIP-ChIP_JURKAT_Human1.95937632
28IKZF1_21737484_ChIP-ChIP_HCT116_Human1.94638848
29POU3F2_20337985_ChIP-ChIP_501MEL_Human1.88599254
30ZNF274_21170338_ChIP-Seq_K562_Hela1.83629446
31MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.72537399
32* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.71793497
33EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.65783706
34HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.63810214
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.56329396
36BMI1_23680149_ChIP-Seq_NPCS_Mouse1.54763117
37TAF15_26573619_Chip-Seq_HEK293_Human1.53903362
38AR_21572438_ChIP-Seq_LNCaP_Human1.50908800
39NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.47757439
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.45084764
41RING1B_27294783_Chip-Seq_ESCs_Mouse1.44249343
42FUS_26573619_Chip-Seq_HEK293_Human1.40933000
43PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.38570426
44ZFP281_18757296_ChIP-ChIP_E14_Mouse1.37424836
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.36679279
46* SMAD4_21799915_ChIP-Seq_A2780_Human1.34536568
47TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.31954421
48RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.29575176
49SOX2_21211035_ChIP-Seq_LN229_Gbm1.28004885
50ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.26745067
51NR3C1_23031785_ChIP-Seq_PC12_Mouse1.26540907
52RNF2_27304074_Chip-Seq_NSC_Mouse1.26372677
53E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.24475611
54ZFP57_27257070_Chip-Seq_ESCs_Mouse1.24089241
55P300_19829295_ChIP-Seq_ESCs_Human1.22948865
56* AR_25329375_ChIP-Seq_VCAP_Human1.18469275
57IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.18005077
58CBP_20019798_ChIP-Seq_JUKART_Human1.18005077
59IRF1_19129219_ChIP-ChIP_H3396_Human1.17856660
60HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.15179218
61RING1B_27294783_Chip-Seq_NPCs_Mouse1.14519108
62* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.14388482
63TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13512904
64SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12069050
65RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.10595913
66TP53_20018659_ChIP-ChIP_R1E_Mouse1.10522938
67RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.09699951
68MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.09522797
69AR_19668381_ChIP-Seq_PC3_Human1.09163637
70KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08847206
71IGF1R_20145208_ChIP-Seq_DFB_Human1.07709276
72SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.07043836
73KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.05825088
74MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04505287
75OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.03574815
76BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.03548733
77* TAL1_26923725_Chip-Seq_HPCs_Mouse1.03283065
78SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02674819
79P53_22127205_ChIP-Seq_FIBROBLAST_Human1.02664052
80* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.02551879
81TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02437522
82SMAD3_21741376_ChIP-Seq_EPCs_Human1.02268790
83ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.01375923
84GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00267857
85PIAS1_25552417_ChIP-Seq_VCAP_Human0.99319032
86AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99045185
87TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98552906
88WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.96973400
89TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.96746874
90ER_23166858_ChIP-Seq_MCF-7_Human0.96345065
91WT1_25993318_ChIP-Seq_PODOCYTE_Human0.96295433
92CTCF_27219007_Chip-Seq_Bcells_Human0.94806549
93OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94012186
94RBPJ_22232070_ChIP-Seq_NCS_Mouse0.93884469
95TET1_21490601_ChIP-Seq_MESCs_Mouse0.92746674
96STAT3_23295773_ChIP-Seq_U87_Human0.92452351
97ETV2_25802403_ChIP-Seq_MESCs_Mouse0.92299394
98TCF4_23295773_ChIP-Seq_U87_Human0.92139497
99CDX2_19796622_ChIP-Seq_MESCs_Mouse0.91317602
100YAP1_20516196_ChIP-Seq_MESCs_Mouse0.90938392
101TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90326928
102POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.90326928
103LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89662290
104TP53_22573176_ChIP-Seq_HFKS_Human0.89071166
105CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.89038232
106FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.88648121
107KDM2B_26808549_Chip-Seq_K562_Human0.88318680
108CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88261597
109TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.87788389
110JUN_21703547_ChIP-Seq_K562_Human0.87550817
111VDR_22108803_ChIP-Seq_LS180_Human0.87495998
112SMAD3_21741376_ChIP-Seq_ESCs_Human0.86574828
113GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.84669524
114RUNX2_22187159_ChIP-Seq_PCA_Human0.84060745
115UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.84003007
116TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.83318686
117ELK4_26923725_Chip-Seq_MESODERM_Mouse0.83261906
118* SMAD4_21741376_ChIP-Seq_HESCs_Human0.82674744
119NR3C1_21868756_ChIP-Seq_MCF10A_Human0.82449241
120* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.82313630
121SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.81752561
122PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.81598792
123CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.80603777
124MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.78751126
125ARNT_22903824_ChIP-Seq_MCF-7_Human0.78620919
126TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77703503

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.02225633
2MP0003880_abnormal_central_pattern4.07807439
3MP0003635_abnormal_synaptic_transmissio3.54279904
4MP0002063_abnormal_learning/memory/cond2.98592754
5MP0009745_abnormal_behavioral_response2.81677443
6MP0002064_seizures2.73249864
7MP0004270_analgesia2.71920288
8MP0006276_abnormal_autonomic_nervous2.65421305
9MP0002572_abnormal_emotion/affect_behav2.60724977
10MP0009046_muscle_twitch2.60220091
11MP0003122_maternal_imprinting2.52552713
12MP0002822_catalepsy2.42826284
13MP0005423_abnormal_somatic_nervous2.40218546
14MP0001968_abnormal_touch/_nociception2.33383122
15MP0002733_abnormal_thermal_nociception2.14825957
16MP0002837_dystrophic_cardiac_calcinosis2.14353560
17MP0001501_abnormal_sleep_pattern2.13713311
18MP0002102_abnormal_ear_morphology2.12504684
19MP0003646_muscle_fatigue2.09626609
20MP0002272_abnormal_nervous_system2.08762887
21MP0002734_abnormal_mechanical_nocicepti2.08385589
22MP0002909_abnormal_adrenal_gland2.02364504
23MP0001440_abnormal_grooming_behavior2.00582830
24MP0002736_abnormal_nociception_after1.97706201
25MP0000751_myopathy1.97518634
26MP0008789_abnormal_olfactory_epithelium1.96646669
27MP0001486_abnormal_startle_reflex1.96484325
28MP0001529_abnormal_vocalization1.95778647
29MP0005646_abnormal_pituitary_gland1.91471579
30MP0005645_abnormal_hypothalamus_physiol1.89399859
31MP0001970_abnormal_pain_threshold1.89188314
32MP0000778_abnormal_nervous_system1.88951930
33MP0002184_abnormal_innervation1.85514572
34MP0004858_abnormal_nervous_system1.80183583
35MP0003329_amyloid_beta_deposits1.79626396
36MP0002067_abnormal_sensory_capabilities1.72631881
37MP0004924_abnormal_behavior1.69477196
38MP0005386_behavior/neurological_phenoty1.69477196
39MP0001502_abnormal_circadian_rhythm1.66115999
40MP0002735_abnormal_chemical_nociception1.65570760
41MP0002557_abnormal_social/conspecific_i1.59120335
42MP0004811_abnormal_neuron_physiology1.56594212
43MP0001984_abnormal_olfaction1.50573486
44MP0009780_abnormal_chondrocyte_physiolo1.50294608
45MP0001905_abnormal_dopamine_level1.45336153
46MP0004130_abnormal_muscle_cell1.43347951
47MP0000955_abnormal_spinal_cord1.42421896
48MP0010386_abnormal_urinary_bladder1.41397150
49MP0000013_abnormal_adipose_tissue1.38285738
50MP0003221_abnormal_cardiomyocyte_apopto1.36552283
51MP0002066_abnormal_motor_capabilities/c1.34392826
52MP0002882_abnormal_neuron_morphology1.32305626
53MP0002653_abnormal_ependyma_morphology1.31807877
54MP0001986_abnormal_taste_sensitivity1.30593148
55MP0008569_lethality_at_weaning1.29281844
56MP0004233_abnormal_muscle_weight1.28415578
57MP0003787_abnormal_imprinting1.26972122
58MP0004142_abnormal_muscle_tone1.24581200
59MP0003283_abnormal_digestive_organ1.23666510
60MP0000750_abnormal_muscle_regeneration1.23348729
61MP0006072_abnormal_retinal_apoptosis1.18643492
62MP0005551_abnormal_eye_electrophysiolog1.17556343
63MP0003879_abnormal_hair_cell1.16207824
64MP0003137_abnormal_impulse_conducting1.15469561
65MP0002638_abnormal_pupillary_reflex1.15159003
66MP0002152_abnormal_brain_morphology1.10002910
67MP0002069_abnormal_eating/drinking_beha1.05505384
68MP0000749_muscle_degeneration1.05416206
69MP0005535_abnormal_body_temperature1.03339754
70MP0000631_abnormal_neuroendocrine_gland0.99510995
71MP0003633_abnormal_nervous_system0.98881965
72MP0008877_abnormal_DNA_methylation0.98833608
73MP0002876_abnormal_thyroid_physiology0.98075305
74MP0002332_abnormal_exercise_endurance0.98073282
75MP0000049_abnormal_middle_ear0.97933333
76MP0004215_abnormal_myocardial_fiber0.97261646
77MP0002234_abnormal_pharynx_morphology0.94878564
78MP0000604_amyloidosis0.90851075
79MP0004145_abnormal_muscle_electrophysio0.89836485
80MP0003121_genomic_imprinting0.89187239
81MP0004885_abnormal_endolymph0.87542798
82MP0003634_abnormal_glial_cell0.86406675
83MP0004085_abnormal_heartbeat0.86250888
84MP0003631_nervous_system_phenotype0.85698582
85MP0002106_abnormal_muscle_physiology0.85060529
86MP0001299_abnormal_eye_distance/0.81997766
87MP0002751_abnormal_autonomic_nervous0.81979829
88MP0005187_abnormal_penis_morphology0.81619854
89MP0005253_abnormal_eye_physiology0.81253740
90MP0002752_abnormal_somatic_nervous0.79719558
91MP0001177_atelectasis0.78728182
92MP0005448_abnormal_energy_balance0.75832070
93MP0000026_abnormal_inner_ear0.75327360
94MP0001188_hyperpigmentation0.74720434
95MP0002090_abnormal_vision0.73961148
96MP0002229_neurodegeneration0.72771400
97MP0003890_abnormal_embryonic-extraembry0.72010311
98MP0005620_abnormal_muscle_contractility0.69778733
99MP0006035_abnormal_mitochondrial_morpho0.69764182
100MP0004036_abnormal_muscle_relaxation0.69706101
101MP0008961_abnormal_basal_metabolism0.69104353
102MP0001963_abnormal_hearing_physiology0.66548508
103MP0003938_abnormal_ear_development0.65791173
104MP0004742_abnormal_vestibular_system0.65733637
105MP0005499_abnormal_olfactory_system0.64793633
106MP0005394_taste/olfaction_phenotype0.64793633
107MP0003123_paternal_imprinting0.64303138
108MP0000538_abnormal_urinary_bladder0.63329699
109MP0002078_abnormal_glucose_homeostasis0.62936681
110MP0005195_abnormal_posterior_eye0.62321440
111MP0008872_abnormal_physiological_respon0.62228898
112MP0002233_abnormal_nose_morphology0.61856042
113MP0005369_muscle_phenotype0.60952713
114MP0003172_abnormal_lysosome_physiology0.60837685
115MP0003075_altered_response_to0.60721451
116MP0003690_abnormal_glial_cell0.59192458
117MP0003861_abnormal_nervous_system0.58876804
118MP0001270_distended_abdomen0.58659175
119MP0003953_abnormal_hormone_level0.58536816
120MP0004133_heterotaxia0.57953279
121MP0008874_decreased_physiological_sensi0.57555745
122MP0001664_abnormal_digestion0.57524730

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.90563180
2Myokymia (HP:0002411)5.39041984
3Visual hallucinations (HP:0002367)4.70041196
4Focal seizures (HP:0007359)4.44677875
5Atonic seizures (HP:0010819)3.98707101
6Febrile seizures (HP:0002373)3.88084395
7Polyphagia (HP:0002591)3.84184284
8Absence seizures (HP:0002121)3.82779389
9Epileptic encephalopathy (HP:0200134)3.82252885
10Pheochromocytoma (HP:0002666)3.73128689
11Limb dystonia (HP:0002451)3.59746806
12Oligomenorrhea (HP:0000876)3.51947239
13Neuroendocrine neoplasm (HP:0100634)3.42938404
14Dialeptic seizures (HP:0011146)3.38517806
15Generalized tonic-clonic seizures (HP:0002069)3.34100157
16Failure to thrive in infancy (HP:0001531)3.31660102
17Progressive cerebellar ataxia (HP:0002073)3.30553528
18Abnormal eating behavior (HP:0100738)3.22458492
19Cortical dysplasia (HP:0002539)3.08233472
20Retinal dysplasia (HP:0007973)3.02473599
21Supranuclear gaze palsy (HP:0000605)2.97968718
22Exercise-induced muscle cramps (HP:0003710)2.95486304
23Ankle clonus (HP:0011448)2.90463039
24Pachygyria (HP:0001302)2.77868584
25Absent speech (HP:0001344)2.77824741
26Mutism (HP:0002300)2.77322580
27Anxiety (HP:0000739)2.75049077
28Agitation (HP:0000713)2.74498254
29Truncal ataxia (HP:0002078)2.73499221
30Depression (HP:0000716)2.73294185
31Rimmed vacuoles (HP:0003805)2.60180032
32Poor suck (HP:0002033)2.58803496
33Abnormality of the lower motor neuron (HP:0002366)2.58110643
34Gait imbalance (HP:0002141)2.57203495
35Hyperventilation (HP:0002883)2.53920336
36Shoulder girdle muscle weakness (HP:0003547)2.53397735
37Spastic tetraplegia (HP:0002510)2.51160420
38Epileptiform EEG discharges (HP:0011182)2.50245216
39Impaired vibration sensation in the lower limbs (HP:0002166)2.50194458
40Torticollis (HP:0000473)2.49373221
41EEG with generalized epileptiform discharges (HP:0011198)2.48781346
42Type II lissencephaly (HP:0007260)2.47557226
43Poor eye contact (HP:0000817)2.46246674
44Dysdiadochokinesis (HP:0002075)2.45977530
45Abnormality of the corticospinal tract (HP:0002492)2.45748048
46Abnormality of the hip-girdle musculature (HP:0001445)2.45014839
47Abnormality of the musculature of the pelvis (HP:0001469)2.45014839
48Amblyopia (HP:0000646)2.43996252
49Action tremor (HP:0002345)2.43445071
50Hypsarrhythmia (HP:0002521)2.39853087
51Progressive inability to walk (HP:0002505)2.37969969
52Abnormality of the labia minora (HP:0012880)2.34509516
53Hypoventilation (HP:0002791)2.33716113
54Neurofibrillary tangles (HP:0002185)2.33330386
55Excessive salivation (HP:0003781)2.33225652
56Drooling (HP:0002307)2.33225652
57Abnormal social behavior (HP:0012433)2.33056879
58Impaired social interactions (HP:0000735)2.33056879
59Inability to walk (HP:0002540)2.31863397
60Focal dystonia (HP:0004373)2.31635890
61Cerebral inclusion bodies (HP:0100314)2.30552881
62Fetal akinesia sequence (HP:0001989)2.27256452
63Hypercortisolism (HP:0001578)2.26895806
64Hemiparesis (HP:0001269)2.26163919
65Distal arthrogryposis (HP:0005684)2.25048710
66Broad-based gait (HP:0002136)2.24422445
67Specific learning disability (HP:0001328)2.23997823
68Narrow nasal bridge (HP:0000446)2.19924176
69Morphological abnormality of the pyramidal tract (HP:0002062)2.19275641
70Neoplasm of the peripheral nervous system (HP:0100007)2.18006815
71Craniofacial dystonia (HP:0012179)2.17966933
72Split foot (HP:0001839)2.16871987
73Abnormal hair whorl (HP:0010721)2.15418137
74Esotropia (HP:0000565)2.14626318
75Spastic gait (HP:0002064)2.12457575
76Growth hormone excess (HP:0000845)2.10259881
77Congenital primary aphakia (HP:0007707)2.06143936
78Hypoplasia of the corpus callosum (HP:0002079)2.05033786
79Atrophy/Degeneration involving motor neurons (HP:0007373)2.04764467
80Myotonia (HP:0002486)2.04227798
81Cerebral hypomyelination (HP:0006808)2.03954888
82Lower limb muscle weakness (HP:0007340)2.03791409
83Dysmetria (HP:0001310)2.03084354
84Diplopia (HP:0000651)2.01363873
85Abnormality of binocular vision (HP:0011514)2.01363873
86Turricephaly (HP:0000262)2.00084223
87Limb-girdle muscle atrophy (HP:0003797)1.99542721
88Degeneration of the lateral corticospinal tracts (HP:0002314)1.98895282
89Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.98895282
90Abnormal EKG (HP:0003115)1.98736463
91Pelvic girdle muscle weakness (HP:0003749)1.97011258
92Exercise-induced myalgia (HP:0003738)1.96910049
93CNS hypomyelination (HP:0003429)1.96880805
94Bradykinesia (HP:0002067)1.96547449
95Polymicrogyria (HP:0002126)1.95438296
96Sleep apnea (HP:0010535)1.93731897
97Urinary urgency (HP:0000012)1.93650248
98Psychosis (HP:0000709)1.92886622
99Neuronal loss in central nervous system (HP:0002529)1.92855407
100Urinary bladder sphincter dysfunction (HP:0002839)1.90897226
101Medial flaring of the eyebrow (HP:0010747)1.90344201
102Poor coordination (HP:0002370)1.90091182
103Status epilepticus (HP:0002133)1.88540459
104Abnormal mitochondria in muscle tissue (HP:0008316)1.87578886
105Abnormality of salivation (HP:0100755)1.87147554
106Hand muscle atrophy (HP:0009130)1.87045712
107Central scotoma (HP:0000603)1.86991937
108Muscular hypotonia of the trunk (HP:0008936)1.86476041
109Postural instability (HP:0002172)1.86269642
110Hypoplasia of the brainstem (HP:0002365)1.84929979
111Aplasia/Hypoplasia of the brainstem (HP:0007362)1.84929979
112Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.84073818
113Nephrogenic diabetes insipidus (HP:0009806)1.83708649
114Frequent falls (HP:0002359)1.82789673
115Limb-girdle muscle weakness (HP:0003325)1.81660185
116Generalized myoclonic seizures (HP:0002123)1.80237294
117Postural tremor (HP:0002174)1.80166158
118Ulnar claw (HP:0001178)1.79690698
119Neoplasm of the heart (HP:0100544)1.79482359
120Calf muscle hypertrophy (HP:0008981)1.78722532
121Impaired pain sensation (HP:0007328)1.78658320
122Abnormality of pain sensation (HP:0010832)1.78658320
123Muscle hypertrophy of the lower extremities (HP:0008968)1.76876473
124True hermaphroditism (HP:0010459)1.75794336
125Congenital stationary night blindness (HP:0007642)1.74875331
126Acute necrotizing encephalopathy (HP:0006965)1.74849159
127Delayed gross motor development (HP:0002194)1.74433139
128Intention tremor (HP:0002080)1.73343312
129Clonus (HP:0002169)1.72107694
130Amyotrophic lateral sclerosis (HP:0007354)1.71161699
131Labial hypoplasia (HP:0000066)1.70959334
132Hypothermia (HP:0002045)1.70835063
133Vaginal atresia (HP:0000148)1.70833637
134Genetic anticipation (HP:0003743)1.70827148
135Exotropia (HP:0000577)1.70714129
136Delusions (HP:0000746)1.70149214
137Akinesia (HP:0002304)1.70136329
138Genital tract atresia (HP:0001827)1.70092951
139Left ventricular hypertrophy (HP:0001712)1.69899611
140Lissencephaly (HP:0001339)1.69240702
141Incomplete penetrance (HP:0003829)1.69217548
142Abnormality of the vocal cords (HP:0008777)1.69124798
143Abnormality of the calf musculature (HP:0001430)1.66801691

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.62747067
2MARK13.60963127
3MAP3K93.45878652
4MAP3K123.25971053
5TRIM282.97696277
6MAP3K42.90294121
7MAP4K22.83900560
8NTRK22.80448438
9MINK12.45208680
10MAP2K72.36763394
11EPHA42.33080649
12WNK32.19167720
13EPHA31.90548623
14PHKG21.89034145
15PHKG11.89034145
16MAP2K41.82102481
17PAK61.79421468
18CASK1.78837446
19LATS21.75683427
20ARAF1.75060226
21CSNK1A1L1.72748480
22KSR21.71343034
23DAPK11.67775729
24KSR11.67421314
25SIK31.66536343
26MAPK131.63177758
27CSNK1G11.56221612
28MAP3K61.51372797
29UHMK11.46798438
30SIK21.45513091
31PRKD31.43928658
32DAPK21.41292774
33TESK11.39811420
34PRPF4B1.38365641
35DDR21.37397515
36TYRO31.34418047
37PINK11.33545427
38CDK51.31271184
39PLK21.26724434
40OBSCN1.25260802
41GRK51.24752558
42LMTK21.17747778
43BCKDK1.15622770
44NTRK11.14821144
45DYRK21.12446757
46EPHB11.10959166
47PAK31.08469900
48ERBB31.08064344
49CAMK2A1.06480029
50PRKCG1.06278747
51ICK1.05703703
52TNIK1.00207860
53CDK180.94288044
54FGR0.92787160
55DYRK1B0.91868309
56SGK4940.90972690
57SGK2230.90972690
58CAMKK10.88203460
59CDK150.87199639
60CDK140.86476955
61NEK10.85284119
62PDGFRA0.79723889
63EPHB20.77254929
64PKN10.77064247
65TAOK20.76931232
66FER0.76640672
67STK380.76199212
68MAP3K110.74568048
69CSNK1G20.74566817
70CAMK2B0.74556354
71BRAF0.73951263
72PRKCZ0.73785990
73CDK11A0.73169851
74CDC42BPA0.72201736
75LIMK10.70605813
76SGK20.68739361
77RET0.68564834
78RPS6KA20.67757444
79CAMKK20.65225573
80CAMK2G0.63440988
81TAOK10.62383873
82CAMK1G0.62297014
83PRKCE0.61546445
84RPS6KA40.61342439
85RAF10.60691807
86AKT30.60665018
87PRKCH0.60346169
88CAMK40.59901542
89PDK30.59824288
90PDK40.59824288
91DYRK1A0.59601773
92CAMK2D0.56121663
93SRPK10.55888987
94MARK20.55779488
95OXSR10.55206593
96NME10.54760578
97MOS0.54131105
98CAMK10.53903782
99MAP2K10.52816271
100ADRBK10.52443841
101MAP3K10.52376147
102BMPR20.51849332
103SGK10.51663367
104STK110.50608377
105DYRK30.49560651
106INSRR0.49423915
107MAP3K130.49030707
108SGK30.46760845
109CDK190.46218337
110MYLK0.45824287
111BCR0.45741931
112CSNK1G30.45387794
113MAPK150.45058704
114CAMK1D0.44210080
115CSNK1A10.43877928
116PRKD20.43830393
117CCNB10.43083884
118PTK2B0.43073245
119PRKACA0.43023152
120PRKAA10.42920252
121FRK0.41074099
122STK38L0.39549452
123MATK0.38589314
124TIE10.37867975
125CSNK1D0.37539534
126GRK70.36406568
127MAPK90.35481581
128TESK20.34889916
129MAPK120.34004920
130MAP3K50.33429111
131PRKACB0.32726061
132CSNK1E0.29809309
133PRKCI0.29492894
134PDK20.28047829
135PIM20.27812786
136PRKG10.27805900
137RPS6KA50.27338523
138ADRBK20.26682404

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.62684778
2Synaptic vesicle cycle_Homo sapiens_hsa047213.55850308
3GABAergic synapse_Homo sapiens_hsa047272.80623119
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.46443474
5Circadian entrainment_Homo sapiens_hsa047132.31274312
6Collecting duct acid secretion_Homo sapiens_hsa049662.25921688
7Morphine addiction_Homo sapiens_hsa050322.24433308
8Glutamatergic synapse_Homo sapiens_hsa047242.06593710
9Olfactory transduction_Homo sapiens_hsa047402.05981468
10Dopaminergic synapse_Homo sapiens_hsa047282.03598971
11Amphetamine addiction_Homo sapiens_hsa050311.97123764
12Long-term potentiation_Homo sapiens_hsa047201.88160954
13Cocaine addiction_Homo sapiens_hsa050301.87791294
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.84014780
15Insulin secretion_Homo sapiens_hsa049111.81814907
16Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.81605847
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.74535102
18Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.74137174
19Steroid biosynthesis_Homo sapiens_hsa001001.71743791
20Serotonergic synapse_Homo sapiens_hsa047261.67579901
21Vibrio cholerae infection_Homo sapiens_hsa051101.62400572
22Cholinergic synapse_Homo sapiens_hsa047251.59141746
23Taste transduction_Homo sapiens_hsa047421.55332325
24Oxidative phosphorylation_Homo sapiens_hsa001901.54857280
25Cardiac muscle contraction_Homo sapiens_hsa042601.49380831
26Renin secretion_Homo sapiens_hsa049241.47922465
27Salivary secretion_Homo sapiens_hsa049701.47876155
28Long-term depression_Homo sapiens_hsa047301.42755508
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.40824291
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.40589038
31Gap junction_Homo sapiens_hsa045401.36302224
32Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.35145558
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.31534803
34Parkinsons disease_Homo sapiens_hsa050121.30986169
35Aldosterone synthesis and secretion_Homo sapiens_hsa049251.30582342
36Oxytocin signaling pathway_Homo sapiens_hsa049211.23782423
37Gastric acid secretion_Homo sapiens_hsa049711.22888817
38GnRH signaling pathway_Homo sapiens_hsa049121.21774041
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.21034019
40Fatty acid biosynthesis_Homo sapiens_hsa000611.20721317
412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.19836987
42Calcium signaling pathway_Homo sapiens_hsa040201.19217184
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.17242548
44Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.16852351
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.16686625
46Phototransduction_Homo sapiens_hsa047441.16586683
47Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.15601475
48Alzheimers disease_Homo sapiens_hsa050101.09907630
49Fatty acid elongation_Homo sapiens_hsa000621.04240083
50Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.00576549
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.97748307
52Regulation of autophagy_Homo sapiens_hsa041400.97121653
53cAMP signaling pathway_Homo sapiens_hsa040240.96608665
54Phenylalanine metabolism_Homo sapiens_hsa003600.96386128
55Type II diabetes mellitus_Homo sapiens_hsa049300.95819211
56Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.95119024
57Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.94347310
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.92030064
59Estrogen signaling pathway_Homo sapiens_hsa049150.91439417
60Axon guidance_Homo sapiens_hsa043600.89828100
61ErbB signaling pathway_Homo sapiens_hsa040120.87620482
62Dilated cardiomyopathy_Homo sapiens_hsa054140.86391320
63Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.85933425
64Arginine and proline metabolism_Homo sapiens_hsa003300.82684419
65Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.80491130
66Huntingtons disease_Homo sapiens_hsa050160.80277041
67Circadian rhythm_Homo sapiens_hsa047100.80082555
68Melanogenesis_Homo sapiens_hsa049160.77197606
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75663515
70Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.73875564
71Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.72696760
72Oocyte meiosis_Homo sapiens_hsa041140.72574457
73Glioma_Homo sapiens_hsa052140.70985725
74Glucagon signaling pathway_Homo sapiens_hsa049220.70208375
75Insulin signaling pathway_Homo sapiens_hsa049100.69150513
76mTOR signaling pathway_Homo sapiens_hsa041500.68965243
77Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.68579394
78Butanoate metabolism_Homo sapiens_hsa006500.68483715
79cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66101749
80beta-Alanine metabolism_Homo sapiens_hsa004100.65521660
81Protein export_Homo sapiens_hsa030600.65000765
82Alcoholism_Homo sapiens_hsa050340.64987720
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62988219
84Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62624457
85Phagosome_Homo sapiens_hsa041450.59858387
86Type I diabetes mellitus_Homo sapiens_hsa049400.59379135
87Pyruvate metabolism_Homo sapiens_hsa006200.58779535
88Prion diseases_Homo sapiens_hsa050200.56593681
89Peroxisome_Homo sapiens_hsa041460.56477647
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.56421291
91Biosynthesis of amino acids_Homo sapiens_hsa012300.56014584
92Ether lipid metabolism_Homo sapiens_hsa005650.55881074
93MAPK signaling pathway_Homo sapiens_hsa040100.55734662
94alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.55664821
95Arginine biosynthesis_Homo sapiens_hsa002200.54665424
96Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.53503680
97Dorso-ventral axis formation_Homo sapiens_hsa043200.50705700
98Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.48418754
99Rheumatoid arthritis_Homo sapiens_hsa053230.48198642
100AMPK signaling pathway_Homo sapiens_hsa041520.47872140
101Fatty acid metabolism_Homo sapiens_hsa012120.47842156
102Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.47491214
103Choline metabolism in cancer_Homo sapiens_hsa052310.46980457
104Carbon metabolism_Homo sapiens_hsa012000.46165577
105Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.45782391
106Tight junction_Homo sapiens_hsa045300.45434973
107Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45184690
108Thyroid hormone synthesis_Homo sapiens_hsa049180.45091352
109Ras signaling pathway_Homo sapiens_hsa040140.44049858
110Sulfur relay system_Homo sapiens_hsa041220.43938756
111Neurotrophin signaling pathway_Homo sapiens_hsa047220.42532246
112Linoleic acid metabolism_Homo sapiens_hsa005910.42286842
113Endometrial cancer_Homo sapiens_hsa052130.42226230
114Ovarian steroidogenesis_Homo sapiens_hsa049130.42160186
115Hedgehog signaling pathway_Homo sapiens_hsa043400.41914191
116Tyrosine metabolism_Homo sapiens_hsa003500.41888219
117Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.41000802
118Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.40831319
119Propanoate metabolism_Homo sapiens_hsa006400.38134180
120Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37797030
121Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36778499
122Phospholipase D signaling pathway_Homo sapiens_hsa040720.36704990
123Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.36613919
124Tryptophan metabolism_Homo sapiens_hsa003800.35895970
125VEGF signaling pathway_Homo sapiens_hsa043700.35869120
126Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.34012399
127Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33963940
128Histidine metabolism_Homo sapiens_hsa003400.33919435
129Renal cell carcinoma_Homo sapiens_hsa052110.32970940
130Wnt signaling pathway_Homo sapiens_hsa043100.32792211
131Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.32123917
132Fructose and mannose metabolism_Homo sapiens_hsa000510.31349877
133Hippo signaling pathway_Homo sapiens_hsa043900.30528877

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