BIVM-ERCC5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.00554314
2COPI coating of Golgi vesicle (GO:0048205)4.63389106
3Golgi transport vesicle coating (GO:0048200)4.63389106
4hemidesmosome assembly (GO:0031581)4.46490188
5nuclear pore organization (GO:0006999)4.01324640
6cell adhesion mediated by integrin (GO:0033627)3.94931538
7cell-substrate junction assembly (GO:0007044)3.86535143
8embryonic process involved in female pregnancy (GO:0060136)3.68186674
9hypotonic response (GO:0006971)3.63737609
10pore complex assembly (GO:0046931)3.52598432
11COPII vesicle coating (GO:0048208)3.51130534
12retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.43961001
13regulation of RNA export from nucleus (GO:0046831)3.40438921
14protein localization to endosome (GO:0036010)3.38312714
15skin morphogenesis (GO:0043589)3.38257092
16regulation of nucleobase-containing compound transport (GO:0032239)3.32721180
17vesicle coating (GO:0006901)3.15785965
18pinocytosis (GO:0006907)3.14600017
19cell-substrate adherens junction assembly (GO:0007045)3.11747027
20focal adhesion assembly (GO:0048041)3.11747027
21negative regulation of erythrocyte differentiation (GO:0045647)3.09015507
22cytoskeletal anchoring at plasma membrane (GO:0007016)2.98227377
23endodermal cell differentiation (GO:0035987)2.91083624
24negative regulation of anoikis (GO:2000811)2.90087633
25negative regulation of fatty acid transport (GO:2000192)2.89192504
26adherens junction assembly (GO:0034333)2.87867106
27definitive hemopoiesis (GO:0060216)2.86110097
28response to laminar fluid shear stress (GO:0034616)2.83740409
29maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.76942440
30insulin-like growth factor receptor signaling pathway (GO:0048009)2.74436516
31cortical actin cytoskeleton organization (GO:0030866)2.72751027
32protein retention in ER lumen (GO:0006621)2.66780677
33regulation of histone H3-K27 methylation (GO:0061085)2.66159033
34basement membrane organization (GO:0071711)2.64259742
35collagen fibril organization (GO:0030199)2.59570025
36dosage compensation (GO:0007549)2.56051863
37regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.55570504
38barbed-end actin filament capping (GO:0051016)2.53945588
39desmosome organization (GO:0002934)2.53099306
40membrane protein ectodomain proteolysis (GO:0006509)2.52276288
41regulation of glucose import in response to insulin stimulus (GO:2001273)2.50264957
42regulation of NFAT protein import into nucleus (GO:0051532)2.49689969
43negative regulation of protein localization to plasma membrane (GO:1903077)2.48036250
44histone H3-K9 demethylation (GO:0033169)2.46000886
45membrane raft organization (GO:0031579)2.45820259
46stress fiber assembly (GO:0043149)2.45619661
47regulation of anoikis (GO:2000209)2.43579317
48peptidyl-threonine modification (GO:0018210)2.41044836
49coronary vasculature morphogenesis (GO:0060977)2.38483387
50corticosteroid receptor signaling pathway (GO:0031958)2.34078950
51positive regulation of blood vessel endothelial cell migration (GO:0043536)2.33674182
52positive regulation of endothelial cell apoptotic process (GO:2000353)2.33642421
53negative regulation of fibrinolysis (GO:0051918)2.33390512
54regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.29710237
55protein hydroxylation (GO:0018126)2.29305658
56iron ion import (GO:0097286)2.28900627
57cellular hyperosmotic response (GO:0071474)2.28624362
58mesodermal cell differentiation (GO:0048333)2.28153333
59phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.26319645
60cortical cytoskeleton organization (GO:0030865)2.25993375
61urea cycle (GO:0000050)2.25702945
62actin filament-based movement (GO:0030048)2.24447268
63regulation of transforming growth factor beta2 production (GO:0032909)2.24211214
64cytoplasmic mRNA processing body assembly (GO:0033962)2.24095931
65histone H3-K36 demethylation (GO:0070544)2.22385100
66cellular response to osmotic stress (GO:0071470)2.21819158
67regulation of extracellular matrix disassembly (GO:0010715)2.21804559
68regulation of transforming growth factor beta1 production (GO:0032908)2.21424280
69urea metabolic process (GO:0019627)2.20071121
70epithelial cell-cell adhesion (GO:0090136)2.17836902
71positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.17577231
72activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.17327419
73negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.17230122
74peptidyl-threonine phosphorylation (GO:0018107)2.16989924
75regulation of response to osmotic stress (GO:0047484)2.16555296
76peptidyl-proline hydroxylation (GO:0019511)2.16428259
77regulation of integrin activation (GO:0033623)2.15789418
78negative regulation of DNA repair (GO:0045738)2.15362867
79histone lysine demethylation (GO:0070076)2.14321124
80apoptotic cell clearance (GO:0043277)2.14122872
81regulation of necroptotic process (GO:0060544)2.13404338
82embryonic eye morphogenesis (GO:0048048)2.13231970
83endoplasmic reticulum unfolded protein response (GO:0030968)2.11591674
84embryonic camera-type eye morphogenesis (GO:0048596)2.11492647
85positive regulation of cellular response to insulin stimulus (GO:1900078)2.11391305
86peptidyl-lysine dimethylation (GO:0018027)2.11332438
87positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.11225555
88negative regulation of necroptotic process (GO:0060546)2.10722503
89positive regulation of receptor recycling (GO:0001921)2.10023550
90alpha-linolenic acid metabolic process (GO:0036109)2.09634829
91very-low-density lipoprotein particle assembly (GO:0034379)2.09472807
92ER-nucleus signaling pathway (GO:0006984)2.09132965
93positive regulation of nuclease activity (GO:0032075)2.08897385
94mRNA stabilization (GO:0048255)2.08332892
95RNA stabilization (GO:0043489)2.08332892
96negative regulation of potassium ion transmembrane transport (GO:1901380)2.08106296
97tricarboxylic acid metabolic process (GO:0072350)2.08061166
98response to epidermal growth factor (GO:0070849)2.07877889
99protein export from nucleus (GO:0006611)2.07758659
100collagen metabolic process (GO:0032963)2.06980559

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.84865659
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.79201256
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.91301928
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.79554718
5CLOCK_20551151_ChIP-Seq_293T_Human2.70244108
6SMAD_19615063_ChIP-ChIP_OVARY_Human2.44427877
7GATA1_22025678_ChIP-Seq_K562_Human2.32009490
8MYB_21317192_ChIP-Seq_ERMYB_Mouse2.25384673
9WT1_19549856_ChIP-ChIP_CCG9911_Human2.11938008
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.00452015
11NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.00343683
12CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.00005351
13E2F7_22180533_ChIP-Seq_HELA_Human1.94667630
14STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.94484816
15KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.94175655
16SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.92947480
17SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.92947480
18AR_21909140_ChIP-Seq_LNCAP_Human1.89078326
19SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.87590654
20TRIM28_21343339_ChIP-Seq_HEK293_Human1.85277353
21Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.85197593
22SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.82491954
23RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.78431164
24STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.76654080
25GATA2_21666600_ChIP-Seq_HMVEC_Human1.75651296
26TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.75199915
27TCF7_22412390_ChIP-Seq_EML_Mouse1.70763167
28SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.66018938
29TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65703362
30P300_27058665_Chip-Seq_ZR-75-30cells_Human1.65568670
31ZNF263_19887448_ChIP-Seq_K562_Human1.62127839
32MYC_22102868_ChIP-Seq_BL_Human1.61228472
33SOX9_24532713_ChIP-Seq_HFSC_Mouse1.59805199
34WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.58326189
35TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.57896250
36KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.57592060
37SALL4_18804426_ChIP-ChIP_XEN_Mouse1.56655334
38ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.55505218
39KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.55127623
40PPAR_26484153_Chip-Seq_NCI-H1993_Human1.53801239
41TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.53026020
42TBX20_22328084_ChIP-Seq_HEART_Mouse1.50521566
43TBX20_22080862_ChIP-Seq_HEART_Mouse1.50521566
44DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.50008873
45MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.49482046
46* BRD4_25478319_ChIP-Seq_HGPS_Human1.48240956
47PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.47296718
48ELK3_25401928_ChIP-Seq_HUVEC_Human1.47014692
49BRD4_27068464_Chip-Seq_AML-cells_Mouse1.45644119
50ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.45019497
51NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.43760295
52NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.43482806
53NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.42274804
54GATA1_19941826_ChIP-Seq_K562_Human1.41748008
55FOXO3_23340844_ChIP-Seq_DLD1_Human1.40160550
56KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.39764007
57UBF1/2_26484160_Chip-Seq_HMECs_Human1.39587315
58CTNNB1_20460455_ChIP-Seq_HCT116_Human1.38888656
59ZNF217_24962896_ChIP-Seq_MCF-7_Human1.37090081
60EP300_21415370_ChIP-Seq_HL-1_Mouse1.36252928
61CDX2_19796622_ChIP-Seq_MESCs_Mouse1.35521550
62ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.33571714
63FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.33022118
64KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.32045367
65STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.31765328
66FOXA2_19822575_ChIP-Seq_HepG2_Human1.29624094
67KDM2B_26808549_Chip-Seq_SUP-B15_Human1.28144940
68RBPJ_22232070_ChIP-Seq_NCS_Mouse1.25470366
69TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.23071880
70SOX2_27498859_Chip-Seq_STOMACH_Mouse1.21564581
71NFIB_24661679_ChIP-Seq_LUNG_Mouse1.21540598
72FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.18959241
73GATA2_19941826_ChIP-Seq_K562_Human1.18203811
74TCF4_18268006_ChIP-ChIP_LS174T_Human1.15993803
75PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.15458209
76GATA1_19941827_ChIP-Seq_MEL_Mouse1.12715669
77SPI1_23127762_ChIP-Seq_K562_Human1.12181627
78VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.11859232
79ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.10794901
80CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.10302905
81KDM2B_26808549_Chip-Seq_DND41_Human1.10204631
82TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.10062735
83KDM2B_26808549_Chip-Seq_JURKAT_Human1.09532343
84EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.08375600
85TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07458585
86ESR1_20079471_ChIP-ChIP_T-47D_Human1.06493596
87SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.04711066
88PU_27001747_Chip-Seq_BMDM_Mouse1.04596587
89RUNX_20019798_ChIP-Seq_JUKART_Human1.04441822
90FOXM1_23109430_ChIP-Seq_U2OS_Human1.04436361
91ESR2_21235772_ChIP-Seq_MCF-7_Human1.03944180
92PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.03563306
93NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.02639294
94THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.02274380
95HIF1A_21447827_ChIP-Seq_MCF-7_Human1.01864839
96CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.00823195
97PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.00363133
98MAF_26560356_Chip-Seq_TH1_Human1.00000149
99LXR_22158963_ChIP-Seq_LIVER_Mouse0.99602605
100GATA4_21415370_ChIP-Seq_HL-1_Mouse0.98428357

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.60319672
2MP0003705_abnormal_hypodermis_morpholog3.77666076
3MP0003566_abnormal_cell_adhesion2.95423044
4MP0010352_gastrointestinal_tract_polyps2.87264917
5MP0002877_abnormal_melanocyte_morpholog2.83871468
6MP0005451_abnormal_body_composition2.73298311
7MP0004272_abnormal_basement_membrane2.65062397
8MP0003300_gastrointestinal_ulcer2.60416620
9MP0005275_abnormal_skin_tensile2.53067561
10MP0003091_abnormal_cell_migration2.30475237
11MP0002009_preneoplasia2.16381942
12MP0004084_abnormal_cardiac_muscle1.98642176
13MP0000751_myopathy1.79871209
14MP0001958_emphysema1.77383147
15MP0002166_altered_tumor_susceptibility1.71742566
16MP0002060_abnormal_skin_morphology1.64441719
17MP0004036_abnormal_muscle_relaxation1.63158028
18MP0005023_abnormal_wound_healing1.62827713
19MP0002396_abnormal_hematopoietic_system1.62571852
20MP0003656_abnormal_erythrocyte_physiolo1.59132977
21MP0004233_abnormal_muscle_weight1.59102918
22MP0003279_aneurysm1.55380267
23MP0003191_abnormal_cellular_cholesterol1.55206088
24MP0005076_abnormal_cell_differentiation1.54585244
25MP0003828_pulmonary_edema1.54467593
26MP0005623_abnormal_meninges_morphology1.53547947
27MP0001915_intracranial_hemorrhage1.51400194
28MP0000733_abnormal_muscle_development1.45227838
29MP0005409_darkened_coat_color1.41356936
30MP0010234_abnormal_vibrissa_follicle1.40387317
31MP0004087_abnormal_muscle_fiber1.39752478
32MP0003221_abnormal_cardiomyocyte_apopto1.38334656
33MP0010368_abnormal_lymphatic_system1.38298160
34MP0005257_abnormal_intraocular_pressure1.37905290
35MP0005503_abnormal_tendon_morphology1.32133521
36MP0004808_abnormal_hematopoietic_stem1.30074598
37MP0004185_abnormal_adipocyte_glucose1.28941626
38MP0000759_abnormal_skeletal_muscle1.28714179
39MP0003868_abnormal_feces_composition1.27275629
40MP0008057_abnormal_DNA_replication1.26956035
41MP0002269_muscular_atrophy1.24980219
42MP0000465_gastrointestinal_hemorrhage1.22633641
43MP0008260_abnormal_autophagy1.20851893
44MP0002896_abnormal_bone_mineralization1.20138140
45MP0000013_abnormal_adipose_tissue1.18381686
46MP0010630_abnormal_cardiac_muscle1.17396697
47MP0005058_abnormal_lysosome_morphology1.14474724
48MP0001849_ear_inflammation1.13546880
49MP0002006_tumorigenesis1.13156888
50MP0006138_congestive_heart_failure1.12913864
51MP0001661_extended_life_span1.10664765
52MP0000747_muscle_weakness1.09839315
53MP0006054_spinal_hemorrhage1.09241032
54MP0005666_abnormal_adipose_tissue1.09083548
55MP0005464_abnormal_platelet_physiology1.07814980
56MP0000767_abnormal_smooth_muscle1.07634505
57MP0005621_abnormal_cell_physiology1.06488378
58MP0003950_abnormal_plasma_membrane1.06083370
59MP0003045_fibrosis1.05802100
60MP0000003_abnormal_adipose_tissue1.05727356
61MP0003763_abnormal_thymus_physiology1.04914828
62MP0001851_eye_inflammation1.02384216
63MP0003453_abnormal_keratinocyte_physiol1.01591789
64MP0003329_amyloid_beta_deposits0.99660706
65MP0009697_abnormal_copulation0.98928359
66MP0003183_abnormal_peptide_metabolism0.98310782
67MP0004947_skin_inflammation0.97502417
68MP0005375_adipose_tissue_phenotype0.96452379
69MP0004264_abnormal_extraembryonic_tissu0.96190874
70MP0000858_altered_metastatic_potential0.94952038
71MP0000569_abnormal_digit_pigmentation0.94324352
72MP0000749_muscle_degeneration0.92198852
73MP0003941_abnormal_skin_development0.91870911
74MP0001243_abnormal_dermal_layer0.91637684
75MP0002086_abnormal_extraembryonic_tissu0.90527724
76MP0005330_cardiomyopathy0.89287010
77MP0003385_abnormal_body_wall0.88173945
78MP0002998_abnormal_bone_remodeling0.84649738
79MP0003984_embryonic_growth_retardation0.83013196
80MP0001348_abnormal_lacrimal_gland0.82133929
81MP0002128_abnormal_blood_circulation0.81599395
82MP0010307_abnormal_tumor_latency0.81493331
83MP0005164_abnormal_response_to0.80598085
84MP0000428_abnormal_craniofacial_morphol0.79384240
85MP0009384_cardiac_valve_regurgitation0.79160353
86MP0002088_abnormal_embryonic_growth/wei0.77035572
87MP0002971_abnormal_brown_adipose0.76599580
88MP0003448_altered_tumor_morphology0.74724826
89MP0001730_embryonic_growth_arrest0.74632405
90MP0009840_abnormal_foam_cell0.74596994
91MP0004858_abnormal_nervous_system0.74353603
92MP0002925_abnormal_cardiovascular_devel0.73615073
93MP0001614_abnormal_blood_vessel0.73346888
94MP0005408_hypopigmentation0.71610897
95MP0004130_abnormal_muscle_cell0.71515188
96MP0009780_abnormal_chondrocyte_physiolo0.70805248
97MP0004134_abnormal_chest_morphology0.70706587
98MP0005397_hematopoietic_system_phenotyp0.70332814
99MP0001545_abnormal_hematopoietic_system0.70332814
100MP0003115_abnormal_respiratory_system0.69648509

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.37029536
2Premature rupture of membranes (HP:0001788)3.85715265
3Arterial tortuosity (HP:0005116)3.41963201
4Atrophic scars (HP:0001075)3.33597757
5Vascular tortuosity (HP:0004948)3.32842906
6Aortic dissection (HP:0002647)3.16991453
7Aortic aneurysm (HP:0004942)3.01353980
8Increased connective tissue (HP:0009025)2.94290455
9Osteolytic defects of the phalanges of the hand (HP:0009771)2.79424702
10Osteolytic defects of the hand bones (HP:0009699)2.79424702
11Wormian bones (HP:0002645)2.66088122
12Fragile skin (HP:0001030)2.64484064
13Increased variability in muscle fiber diameter (HP:0003557)2.59320865
14Exercise-induced myalgia (HP:0003738)2.52661602
15Dilatation of the ascending aorta (HP:0005111)2.51708530
16Abnormality of skeletal muscle fiber size (HP:0012084)2.49671890
17Type 1 muscle fiber predominance (HP:0003803)2.49545894
18Distal lower limb amyotrophy (HP:0008944)2.45149326
19Termporal pattern (HP:0011008)2.41610561
20Insidious onset (HP:0003587)2.41610561
21Aneurysm (HP:0002617)2.38486030
22Peritonitis (HP:0002586)2.38199963
23Ankyloglossia (HP:0010296)2.38040474
24Centrally nucleated skeletal muscle fibers (HP:0003687)2.36777498
25Flat acetabular roof (HP:0003180)2.36050675
26Vertebral compression fractures (HP:0002953)2.33019866
27Cerebral aneurysm (HP:0004944)2.31161076
28Subacute progressive viral hepatitis (HP:0006572)2.27987879
29Right ventricular cardiomyopathy (HP:0011663)2.27429532
30Back pain (HP:0003418)2.27355083
31Mitral valve prolapse (HP:0001634)2.23105746
32Vertebral arch anomaly (HP:0008438)2.19407178
33Ankle contracture (HP:0006466)2.16494056
34Spinal rigidity (HP:0003306)2.16380619
35Spondylolisthesis (HP:0003302)2.12853599
36Abnormality of oral frenula (HP:0000190)2.12546058
37Bladder diverticulum (HP:0000015)2.10796167
38Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.08921205
39Increased mean platelet volume (HP:0011877)2.07279207
40Mildly elevated creatine phosphokinase (HP:0008180)2.05183993
41Hyperacusis (HP:0010780)2.03877499
42Soft skin (HP:0000977)2.00829310
43Overgrowth (HP:0001548)2.00072478
44Abnormality of the acetabulum (HP:0003170)2.00070682
45Cervical subluxation (HP:0003308)1.99381139
46Short nail (HP:0001799)1.99373039
47Syringomyelia (HP:0003396)1.98605154
48Spinal cord lesions (HP:0100561)1.98605154
49Papillary thyroid carcinoma (HP:0002895)1.97021813
50Neonatal short-limb short stature (HP:0008921)1.96298839
51Asymmetry of the thorax (HP:0001555)1.91523634
52Abnormal platelet volume (HP:0011876)1.91262499
53Joint laxity (HP:0001388)1.89818495
54Abnormality of the left ventricular outflow tract (HP:0011103)1.89090987
55Subaortic stenosis (HP:0001682)1.89090987
56Abnormality of the common coagulation pathway (HP:0010990)1.89056882
57Broad face (HP:0000283)1.86102375
58Periodontitis (HP:0000704)1.83418748
59Abnormality of dentin (HP:0010299)1.83298455
60Thin bony cortex (HP:0002753)1.82530920
61Advanced eruption of teeth (HP:0006288)1.82163070
62Fatigue (HP:0012378)1.81925383
63Deep venous thrombosis (HP:0002625)1.78793928
64Milia (HP:0001056)1.77733667
65Achilles tendon contracture (HP:0001771)1.76371041
66Breech presentation (HP:0001623)1.76049520
67Mitral stenosis (HP:0001718)1.76000325
68Cupped ribs (HP:0000887)1.75974845
69Ventricular tachycardia (HP:0004756)1.75529463
70Blue sclerae (HP:0000592)1.75068672
71Natal tooth (HP:0000695)1.73969186
72Polycythemia (HP:0001901)1.73919277
73Upper limb amyotrophy (HP:0009129)1.73000357
74Distal upper limb amyotrophy (HP:0007149)1.73000357
75Gingival bleeding (HP:0000225)1.71893609
76Delayed closure of the anterior fontanelle (HP:0001476)1.71520536
77Lower limb amyotrophy (HP:0007210)1.71208512
78Abnormal delivery (HP:0001787)1.71002744
79Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.70673149
80Nemaline bodies (HP:0003798)1.70055947
81Mitral regurgitation (HP:0001653)1.69489802
82Relative macrocephaly (HP:0004482)1.69433197
83Disproportionate tall stature (HP:0001519)1.69014057
84Coarse hair (HP:0002208)1.67573488
85Ulnar bowing (HP:0003031)1.67271286
86Dysmetric saccades (HP:0000641)1.66717943
87Abnormality of the Achilles tendon (HP:0005109)1.66120418
88Absent frontal sinuses (HP:0002688)1.64729700
89Dislocated radial head (HP:0003083)1.63870620
90Hammertoe (HP:0001765)1.63660774
91Muscle fiber inclusion bodies (HP:0100299)1.62908430
92Heterotopia (HP:0002282)1.62402023
93Menorrhagia (HP:0000132)1.61989229
94Abnormality of the fingertips (HP:0001211)1.61722233
95Abnormal ossification of hand bones (HP:0005921)1.61408404
96Elbow flexion contracture (HP:0002987)1.61272687
97Abnormality of carpal bone ossification (HP:0006257)1.61231215
98Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.60266868
99Asymmetric septal hypertrophy (HP:0001670)1.59416696
100Myocardial infarction (HP:0001658)1.58336821

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.46907740
2PDGFRA3.28427110
3EEF2K2.78647869
4TTN2.73716830
5PRPF4B2.64139600
6NEK92.63014460
7TRIB32.61091261
8SCYL22.58868185
9MST1R2.42000231
10RIPK12.31610817
11FGFR42.13011716
12ICK1.96492386
13LATS11.83360692
14BRD41.76251264
15TRPM71.76112109
16FGFR31.65674429
17MET1.64446555
18KSR21.58902296
19JAK11.50056269
20PKN21.47030498
21CAMK1G1.42974380
22CDK61.42935262
23PIK3CG1.40532813
24PDGFRB1.39111697
25TGFBR21.38933325
26CAMK1D1.36094978
27ERN11.34876844
28MAP3K141.33534646
29MAP3K61.30460039
30RET1.29873583
31NTRK11.29553374
32LATS21.25372704
33DDR21.24062031
34PAK21.23231796
35SMG11.22086331
36MAP3K101.21461252
37MTOR1.20936966
38MAP2K31.16123608
39SIK11.15501153
40WNK11.13361386
41CDC42BPA1.11547767
42MAP3K21.11515544
43AKT31.00384579
44PTK20.91976442
45BMPR20.91546299
46JAK30.89700081
47OBSCN0.88768418
48MOS0.86724118
49STK380.84132957
50KSR10.83638275
51ZAP700.82605775
52MAPK110.81908476
53EPHB10.81293178
54RAF10.78548084
55TYK20.76651605
56JAK20.76334533
57MAP3K130.75399231
58SGK30.72970923
59PAK40.71927085
60EPHA30.71736498
61CLK10.69723450
62EIF2AK10.64391607
63FLT30.62258864
64MARK20.60401891
65ERBB30.59931809
66MAP3K70.59905767
67PRKAA20.59744079
68RIPK40.58474050
69IRAK30.57672546
70CDK40.57662999
71YES10.56196749
72MAP3K10.52595926
73RPS6KA20.51336997
74BTK0.47638659
75MAP3K50.47231713
76MYLK0.46883248
77PDPK10.46623849
78PTK60.46596578
79BMX0.44083949
80MAP3K80.43835231
81CSF1R0.43598973
82HCK0.43355975
83MAPK70.42700403
84DMPK0.42297648
85RPS6KB20.42281630
86MELK0.42189714
87MAPK100.42037477
88STK100.41749817
89MAP3K30.39992562
90ROCK20.37704371
91DYRK1B0.36956680
92LMTK20.35583277
93CDK90.35465961
94PDK10.34309907
95CAMKK20.30615239
96ERBB40.30526034
97MAPK120.30148273
98CHEK10.29542335
99TEC0.29530411
100RPS6KB10.29422493

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.37186891
2Chronic myeloid leukemia_Homo sapiens_hsa052202.04308808
3ECM-receptor interaction_Homo sapiens_hsa045121.99457456
4Focal adhesion_Homo sapiens_hsa045101.98804791
5Non-small cell lung cancer_Homo sapiens_hsa052231.88346159
6Pancreatic cancer_Homo sapiens_hsa052121.83868865
7AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.73828855
8Small cell lung cancer_Homo sapiens_hsa052221.72255120
9Adherens junction_Homo sapiens_hsa045201.63378057
10Thyroid cancer_Homo sapiens_hsa052161.61280272
11Endometrial cancer_Homo sapiens_hsa052131.61122894
12Renal cell carcinoma_Homo sapiens_hsa052111.56121035
13Acute myeloid leukemia_Homo sapiens_hsa052211.55848186
14Central carbon metabolism in cancer_Homo sapiens_hsa052301.51976830
15Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.48240760
16Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.41175531
17Proteoglycans in cancer_Homo sapiens_hsa052051.39955177
18Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.39950513
19Thyroid hormone signaling pathway_Homo sapiens_hsa049191.37027543
20Dilated cardiomyopathy_Homo sapiens_hsa054141.34128456
21Amoebiasis_Homo sapiens_hsa051461.33582278
22Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.33023647
23Glioma_Homo sapiens_hsa052141.27942840
24Other glycan degradation_Homo sapiens_hsa005111.24878333
25MicroRNAs in cancer_Homo sapiens_hsa052061.22264065
26Platelet activation_Homo sapiens_hsa046111.22209728
27Inositol phosphate metabolism_Homo sapiens_hsa005621.22047787
28Leukocyte transendothelial migration_Homo sapiens_hsa046701.21349975
29ErbB signaling pathway_Homo sapiens_hsa040121.20566308
30Phosphatidylinositol signaling system_Homo sapiens_hsa040701.20240259
31Prolactin signaling pathway_Homo sapiens_hsa049171.20035158
32mTOR signaling pathway_Homo sapiens_hsa041501.20014421
33Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.18965519
34Bladder cancer_Homo sapiens_hsa052191.18713978
35Colorectal cancer_Homo sapiens_hsa052101.15121637
36B cell receptor signaling pathway_Homo sapiens_hsa046621.14300726
37Prostate cancer_Homo sapiens_hsa052151.14186739
38Regulation of actin cytoskeleton_Homo sapiens_hsa048101.12840152
39Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.11251266
40Neurotrophin signaling pathway_Homo sapiens_hsa047221.11134276
41VEGF signaling pathway_Homo sapiens_hsa043701.07113850
42Insulin signaling pathway_Homo sapiens_hsa049101.05852108
43Hepatitis B_Homo sapiens_hsa051611.04520751
44Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.97293169
45Insulin resistance_Homo sapiens_hsa049310.96293449
46Choline metabolism in cancer_Homo sapiens_hsa052310.96061106
47Toxoplasmosis_Homo sapiens_hsa051450.95991024
48Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.95170295
49Viral carcinogenesis_Homo sapiens_hsa052030.91242628
50Lysine degradation_Homo sapiens_hsa003100.87737714
51Complement and coagulation cascades_Homo sapiens_hsa046100.87225281
52Adipocytokine signaling pathway_Homo sapiens_hsa049200.86730015
53AMPK signaling pathway_Homo sapiens_hsa041520.85980006
54Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.84827980
55Renin-angiotensin system_Homo sapiens_hsa046140.84002057
56Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.83249036
57GnRH signaling pathway_Homo sapiens_hsa049120.82667582
58FoxO signaling pathway_Homo sapiens_hsa040680.79969165
59Pentose phosphate pathway_Homo sapiens_hsa000300.79458528
60Phospholipase D signaling pathway_Homo sapiens_hsa040720.78109062
61Shigellosis_Homo sapiens_hsa051310.77205167
62Apoptosis_Homo sapiens_hsa042100.75599116
63HIF-1 signaling pathway_Homo sapiens_hsa040660.74364140
64Longevity regulating pathway - mammal_Homo sapiens_hsa042110.73650423
65Prion diseases_Homo sapiens_hsa050200.72910871
66Jak-STAT signaling pathway_Homo sapiens_hsa046300.72101220
67Protein digestion and absorption_Homo sapiens_hsa049740.71402544
68Pathways in cancer_Homo sapiens_hsa052000.71297578
69Measles_Homo sapiens_hsa051620.70583618
70Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69786514
71Hepatitis C_Homo sapiens_hsa051600.69505331
72T cell receptor signaling pathway_Homo sapiens_hsa046600.68939798
73Glycosaminoglycan degradation_Homo sapiens_hsa005310.68876625
74PI3K-Akt signaling pathway_Homo sapiens_hsa041510.68340134
75Estrogen signaling pathway_Homo sapiens_hsa049150.67952787
76Osteoclast differentiation_Homo sapiens_hsa043800.66981053
77TNF signaling pathway_Homo sapiens_hsa046680.66119069
78Fatty acid biosynthesis_Homo sapiens_hsa000610.65977816
79Influenza A_Homo sapiens_hsa051640.65846887
80Viral myocarditis_Homo sapiens_hsa054160.65603098
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.63015723
82Long-term potentiation_Homo sapiens_hsa047200.61940921
83Endocytosis_Homo sapiens_hsa041440.58262208
84Galactose metabolism_Homo sapiens_hsa000520.57327812
85Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.55492793
86Notch signaling pathway_Homo sapiens_hsa043300.55334902
87Arginine biosynthesis_Homo sapiens_hsa002200.55170708
88Leishmaniasis_Homo sapiens_hsa051400.55158287
89Carbon metabolism_Homo sapiens_hsa012000.54493128
90Gap junction_Homo sapiens_hsa045400.53497318
91Glucagon signaling pathway_Homo sapiens_hsa049220.52144216
92Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.51745847
93Melanoma_Homo sapiens_hsa052180.51378793
94HTLV-I infection_Homo sapiens_hsa051660.51234853
95Malaria_Homo sapiens_hsa051440.50728433
96Type II diabetes mellitus_Homo sapiens_hsa049300.50555435
97PPAR signaling pathway_Homo sapiens_hsa033200.49759748
98Salmonella infection_Homo sapiens_hsa051320.46504901
99Toll-like receptor signaling pathway_Homo sapiens_hsa046200.46383080
100Rap1 signaling pathway_Homo sapiens_hsa040150.44464573

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »