BIRC7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the inhibitor of apoptosis protein (IAP) family, and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit apoptosis alone. Elevated levels of the encoded protein may be associated with cancer progression and play a role in chemotherapy sensitivity. Alternative splicing results in multiple transcript variants NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lens fiber cell development (GO:0070307)9.96402706
2purine nucleotide transport (GO:0015865)8.79141692
3melanocyte differentiation (GO:0030318)8.68255954
4pigment cell differentiation (GO:0050931)8.57733800
5gamma-aminobutyric acid transport (GO:0015812)8.17842427
6gap junction assembly (GO:0016264)7.32772653
7cellular response to thyroid hormone stimulus (GO:0097067)7.00261559
8tyrosine metabolic process (GO:0006570)6.76819740
9response to thyroid hormone (GO:0097066)6.74730065
10nucleoside transport (GO:0015858)6.61389214
11glial cell proliferation (GO:0014009)6.58770695
12regulation of tight junction assembly (GO:2000810)6.34912805
13atrial cardiac muscle cell action potential (GO:0086014)6.32637986
14lens fiber cell differentiation (GO:0070306)6.32558851
15developmental pigmentation (GO:0048066)5.87600993
16regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)5.50679768
17negative regulation of cardiac muscle tissue growth (GO:0055022)5.41030631
18negative regulation of heart growth (GO:0061117)5.41030631
19neuroepithelial cell differentiation (GO:0060563)5.38134491
20phenol-containing compound biosynthetic process (GO:0046189)5.30436731
21regulation of glomerular filtration (GO:0003093)5.06258874
22basement membrane organization (GO:0071711)5.06106519
23melanosome organization (GO:0032438)4.95896925
24cellular response to reactive nitrogen species (GO:1902170)4.88792827
25pigment biosynthetic process (GO:0046148)4.84867111
26endothelium development (GO:0003158)4.82744731
27pigment granule organization (GO:0048753)4.79056264
28endosome to melanosome transport (GO:0035646)4.78030085
29endosome to pigment granule transport (GO:0043485)4.78030085
30positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)4.69822697
31cell communication by electrical coupling (GO:0010644)4.67157202
32regulation of gene silencing by RNA (GO:0060966)4.60081922
33regulation of posttranscriptional gene silencing (GO:0060147)4.60081922
34regulation of gene silencing by miRNA (GO:0060964)4.60081922
35secondary metabolic process (GO:0019748)4.51276109
36mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)4.45030328
37germ cell migration (GO:0008354)4.34540773
38skeletal muscle tissue regeneration (GO:0043403)4.32677100
39cellular response to nitric oxide (GO:0071732)4.30354655
40response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.19461013
41regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.14471591
42polarized epithelial cell differentiation (GO:0030859)4.14176459
43positive regulation of neuroblast proliferation (GO:0002052)4.10134519
44pigmentation (GO:0043473)4.06006478
45pigment metabolic process (GO:0042440)4.05777927
46myelination in peripheral nervous system (GO:0022011)4.04159940
47peripheral nervous system axon ensheathment (GO:0032292)4.04159940
48histone H3-K9 demethylation (GO:0033169)4.02013822
49renal system process involved in regulation of blood volume (GO:0001977)4.00556321
50nucleotide transport (GO:0006862)3.97237489
51epithelial cell maturation (GO:0002070)3.96163202
52amino sugar catabolic process (GO:0046348)3.81568339
53protein localization to endosome (GO:0036010)3.80139800
54negative regulation of astrocyte differentiation (GO:0048712)3.74084366
55negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.72475167
56regulation of early endosome to late endosome transport (GO:2000641)3.71630398
57negative regulation of cardiac muscle tissue development (GO:0055026)3.71282412
58somatic stem cell division (GO:0048103)3.66687921
59positive regulation of pseudopodium assembly (GO:0031274)3.63582772
60glycolytic process (GO:0006096)3.58346274
61protein K6-linked ubiquitination (GO:0085020)3.57442556
62lateral sprouting from an epithelium (GO:0060601)3.56135122
63regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.56056271
64cytokine production involved in immune response (GO:0002367)3.55728938
65lens morphogenesis in camera-type eye (GO:0002089)3.54932930
66establishment of apical/basal cell polarity (GO:0035089)3.54876146
67cellular hyperosmotic response (GO:0071474)3.53375184
68cellular response to osmotic stress (GO:0071470)3.51198572
69N-acetylneuraminate metabolic process (GO:0006054)3.49878026
70histone H4-K12 acetylation (GO:0043983)3.41689741
71DNA replication initiation (GO:0006270)3.39892011
72mast cell activation involved in immune response (GO:0002279)3.37753851
73mast cell degranulation (GO:0043303)3.37753851
74G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.36524695
75renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.33512503
76regulation of pseudopodium assembly (GO:0031272)3.29687118
77striated muscle atrophy (GO:0014891)3.28023699
78negative regulation of androgen receptor signaling pathway (GO:0060766)3.27385560
79neuron maturation (GO:0042551)3.25601485
80response to dietary excess (GO:0002021)3.24992982
81G1 DNA damage checkpoint (GO:0044783)3.24249876
82planar cell polarity pathway involved in neural tube closure (GO:0090179)3.22909607
83IMP biosynthetic process (GO:0006188)3.22520891
84cornea development in camera-type eye (GO:0061303)3.20686608
85proline biosynthetic process (GO:0006561)3.20246517
86regulation of superoxide anion generation (GO:0032928)3.17893610
87carnitine metabolic process (GO:0009437)3.17641285
88regulation of developmental pigmentation (GO:0048070)3.16512470
89response to nitric oxide (GO:0071731)3.14929377
90angiogenesis involved in wound healing (GO:0060055)3.13729330
91folic acid-containing compound biosynthetic process (GO:0009396)3.13496470
92epithelial cell-cell adhesion (GO:0090136)3.13478507
93regulation of protein sumoylation (GO:0033233)3.13476740
94enteric nervous system development (GO:0048484)3.12167759
95somatic hypermutation of immunoglobulin genes (GO:0016446)3.11128839
96somatic diversification of immune receptors via somatic mutation (GO:0002566)3.11128839
97camera-type eye development (GO:0043010)3.10388390
98fructose metabolic process (GO:0006000)3.09549140
99response to muscle activity (GO:0014850)3.08089660
100sexual reproduction (GO:0019953)3.07931259
101protein localization to kinetochore (GO:0034501)3.07383725
102lymphoid progenitor cell differentiation (GO:0002320)3.06738099
103positive regulation of vascular permeability (GO:0043117)3.06386765
104anterior/posterior axis specification, embryo (GO:0008595)3.06217976
105negative regulation of macroautophagy (GO:0016242)3.04883686
106protein localization to cell surface (GO:0034394)3.04536931
107mitotic G1 DNA damage checkpoint (GO:0031571)3.04137971
108establishment or maintenance of monopolar cell polarity (GO:0061339)3.02946709
109establishment of monopolar cell polarity (GO:0061162)3.02946709
110establishment of integrated proviral latency (GO:0075713)3.01541182
111hemidesmosome assembly (GO:0031581)3.00671506
112regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.00092308
113regulation of hippo signaling (GO:0035330)2.99925770
114peptidyl-proline hydroxylation (GO:0019511)2.98891610
115histone arginine methylation (GO:0034969)2.98879296
116carbohydrate phosphorylation (GO:0046835)2.97291958
117response to UV-C (GO:0010225)2.96283554
118muscle cell cellular homeostasis (GO:0046716)2.95641021
119endothelial cell chemotaxis (GO:0035767)2.95052703
120spliceosomal tri-snRNP complex assembly (GO:0000244)2.94866456
121skeletal muscle adaptation (GO:0043501)2.93014987
122regulation of integrin-mediated signaling pathway (GO:2001044)2.90766082
123DNA unwinding involved in DNA replication (GO:0006268)2.90722102
124gluconeogenesis (GO:0006094)2.89474359
125megakaryocyte development (GO:0035855)2.89163011
126semaphorin-plexin signaling pathway (GO:0071526)2.87025770
127positive regulation of protein kinase C signaling (GO:0090037)2.86805261
128formation of translation preinitiation complex (GO:0001731)2.86738622
129barbed-end actin filament capping (GO:0051016)2.86191355
130histone H4-K5 acetylation (GO:0043981)2.85939117
131histone H4-K8 acetylation (GO:0043982)2.85939117
132muscle atrophy (GO:0014889)2.85244715
133hyperosmotic salinity response (GO:0042538)2.84973197
134pigment granule transport (GO:0051904)2.84409712
135glucose 6-phosphate metabolic process (GO:0051156)2.84381139
136ovarian follicle development (GO:0001541)2.84140036
137columnar/cuboidal epithelial cell differentiation (GO:0002065)2.83551624
138heterochromatin organization (GO:0070828)2.83481775
139positive regulation of p38MAPK cascade (GO:1900745)2.83060442
140regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.82895119
141DNA replication-dependent nucleosome assembly (GO:0006335)2.81865505
142DNA replication-dependent nucleosome organization (GO:0034723)2.81865505
143negative regulation of metanephros development (GO:0072217)2.80370875
144pigment granule localization (GO:0051875)2.79812594
145response to salt stress (GO:0009651)2.79730110
146regulation of neuroblast proliferation (GO:1902692)2.78674840
147glycosphingolipid metabolic process (GO:0006687)2.77382117
148sphingomyelin metabolic process (GO:0006684)2.76806516
149regulation of endothelial cell chemotaxis (GO:2001026)2.75926100
150collecting duct development (GO:0072044)2.74842919
151nuclear pore organization (GO:0006999)2.73974090
152chondroitin sulfate catabolic process (GO:0030207)2.73828361
153detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.73562769
154regulation of nuclear cell cycle DNA replication (GO:0033262)2.72152503
155negative regulation of intracellular steroid hormone receptor signaling pathway (GO:0033144)2.70579814
156glial cell migration (GO:0008347)2.70214612
157glycosphingolipid catabolic process (GO:0046479)2.69889211
158establishment of pigment granule localization (GO:0051905)2.69334005
159vascular endothelial growth factor signaling pathway (GO:0038084)2.69266154
160paraxial mesoderm development (GO:0048339)2.69165906
161nephron tubule formation (GO:0072079)2.68921318
162regulation of apoptotic process involved in morphogenesis (GO:1902337)2.67988827
163visual perception (GO:0007601)2.67678621
164erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.67620714
165L-phenylalanine metabolic process (GO:0006558)2.67620714
166negative regulation of catenin import into nucleus (GO:0035414)2.67567757
167nuclear pore complex assembly (GO:0051292)2.66752943
168response to methylmercury (GO:0051597)2.66449468
169pinocytosis (GO:0006907)2.66179324
170chronic inflammatory response (GO:0002544)2.65236620
171regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.64454248
172sensory perception of light stimulus (GO:0050953)2.64416066
173nodal signaling pathway (GO:0038092)2.64172802
174mitotic sister chromatid segregation (GO:0000070)2.63980713
175vesicle targeting (GO:0006903)2.63822680
176eye development (GO:0001654)2.62529855
177epithelial cell fate commitment (GO:0072148)2.58774906
178mitotic G1/S transition checkpoint (GO:0044819)2.58058272
179embryonic foregut morphogenesis (GO:0048617)2.57935369
180postsynaptic membrane organization (GO:0001941)2.56785225
181positive regulation of DNA-dependent DNA replication (GO:2000105)2.54165196
182DNA strand elongation involved in DNA replication (GO:0006271)2.52035089
183notochord development (GO:0030903)2.51320712
184negative regulation of cartilage development (GO:0061037)2.47673435
185regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.46684957
186apoptotic process involved in morphogenesis (GO:0060561)2.46259605
187Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.45798602
188non-canonical Wnt signaling pathway (GO:0035567)2.45649507
189melanin biosynthetic process (GO:0042438)16.2522223
190melanin metabolic process (GO:0006582)15.0023724
191lens development in camera-type eye (GO:0002088)13.8178091
192secondary metabolite biosynthetic process (GO:0044550)13.6499169
193adenine nucleotide transport (GO:0051503)10.1633276
194purine ribonucleotide transport (GO:0015868)10.1100399

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.63504564
2NANOG_18700969_ChIP-ChIP_MESCs_Mouse3.99338067
3PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.93179748
4SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.63965832
5POU5F1_18700969_ChIP-ChIP_MESCs_Mouse3.48906582
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.28026590
7SMAD3_22036565_ChIP-Seq_ESCs_Mouse3.27250274
8MYC_19079543_ChIP-ChIP_MESCs_Mouse3.24001926
9MYC_18555785_ChIP-Seq_MESCs_Mouse3.21975849
10KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.17657508
11KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.17657508
12KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.17657508
13SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.99215758
14TCF3_18692474_ChIP-Seq_MEFs_Mouse2.97050303
15NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.90141749
16THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.89160728
17TP63_17297297_ChIP-ChIP_HaCaT_Human2.85930896
18ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.82036002
19NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.78659438
20ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.72237321
21BP1_19119308_ChIP-ChIP_Hs578T_Human2.65820265
22ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.65030066
23SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.61934168
24PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.56578126
25RARG_19884340_ChIP-ChIP_MEFs_Mouse2.53725848
26TFEB_21752829_ChIP-Seq_HELA_Human2.53465306
27SOX2_18555785_ChIP-Seq_MESCs_Mouse2.52985086
28* MITF_21258399_ChIP-Seq_MELANOMA_Human2.46456531
29TCF3_18692474_ChIP-Seq_MESCs_Mouse2.45995136
30NANOG_18555785_ChIP-Seq_MESCs_Mouse2.43983211
31POU5F1_16518401_ChIP-PET_MESCs_Mouse2.36463290
32SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.32926208
33RACK7_27058665_Chip-Seq_MCF-7_Human2.20225476
34EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.17705856
35MYC_19030024_ChIP-ChIP_MESCs_Mouse2.09295358
36STAT3_1855785_ChIP-Seq_MESCs_Mouse2.07659449
37OCT4_18692474_ChIP-Seq_MEFs_Mouse2.06588680
38SOX2_18692474_ChIP-Seq_MEFs_Mouse2.06068048
39NANOG_18358816_ChIP-ChIP_MESCs_Mouse2.03966451
40RXR_22158963_ChIP-Seq_LIVER_Mouse2.02734613
41NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.01090465
42KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.01068379
43ZFP281_18757296_ChIP-ChIP_E14_Mouse2.00683080
44ELK3_25401928_ChIP-Seq_HUVEC_Human1.98859534
45CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.95677520
46NANOG_18692474_ChIP-Seq_MEFs_Mouse1.94141823
47KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.93658266
48NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.91992364
49E2F4_17652178_ChIP-ChIP_JURKAT_Human1.90150427
50CLOCK_20551151_ChIP-Seq_293T_Human1.89644686
51HIF1A_21447827_ChIP-Seq_MCF-7_Human1.87003411
52TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82978394
53KDM2B_26808549_Chip-Seq_SUP-B15_Human1.82330681
54NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.81004181
55EGR1_19374776_ChIP-ChIP_THP-1_Human1.79970265
56MYC_18358816_ChIP-ChIP_MESCs_Mouse1.79005949
57SA1_27219007_Chip-Seq_ERYTHROID_Human1.73102998
58EGR1_19032775_ChIP-ChIP_M12_Human1.72746329
59CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.71020943
60NANOG_18692474_ChIP-Seq_MESCs_Mouse1.70335268
61SALL4_18804426_ChIP-ChIP_XEN_Mouse1.65958250
62POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.65951074
63TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.65720487
64NELFA_20434984_ChIP-Seq_ESCs_Mouse1.65125344
65ZFP281_27345836_Chip-Seq_ESCs_Mouse1.63066666
66KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.59793762
67FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.58640977
68TP53_20018659_ChIP-ChIP_R1E_Mouse1.58300970
69SOX2_18692474_ChIP-Seq_MESCs_Mouse1.57991537
70TET1_21451524_ChIP-Seq_MESCs_Mouse1.57908195
71NANOG_16518401_ChIP-PET_MESCs_Mouse1.55539314
72TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.54801489
73VDR_21846776_ChIP-Seq_THP-1_Human1.49029649
74POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.48777501
75PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.48686311
76NANOG_16153702_ChIP-ChIP_HESCs_Human1.47675507
77MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.47563750
78NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.47269702
79FOXM1_23109430_ChIP-Seq_U2OS_Human1.47250927
80POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.47016697
81ZNF263_19887448_ChIP-Seq_K562_Human1.47007199
82* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.44025225
83KDM2B_26808549_Chip-Seq_K562_Human1.43330328
84CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.41037520
85CTCF_27219007_Chip-Seq_ERYTHROID_Human1.40534942
86PPARA_22158963_ChIP-Seq_LIVER_Mouse1.39882650
87SALL1_21062744_ChIP-ChIP_HESCs_Human1.39233425
88SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.38468308
89TBX3_20139965_ChIP-Seq_ESCs_Mouse1.38349111
90TBX3_20139965_ChIP-Seq_MESCs_Mouse1.37037799
91RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.35555527
92P300_27058665_Chip-Seq_ZR-75-30cells_Human1.35425118
93KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.34257268
94NANOG_21062744_ChIP-ChIP_HESCs_Human1.33887599
95ERG_21242973_ChIP-ChIP_JURKAT_Human1.33413231
96E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.32594848
97TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.31072766
98TBX20_22328084_ChIP-Seq_HEART_Mouse1.30584899
99TBX20_22080862_ChIP-Seq_HEART_Mouse1.30584899
100RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.29084349
101ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.27957266
102CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.27705254
103YY1_21170310_ChIP-Seq_MESCs_Mouse1.27505928
104SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.26023120
105POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.24926821
106KAP1_27257070_Chip-Seq_ESCs_Mouse1.23652646
107KDM2B_26808549_Chip-Seq_DND41_Human1.23277770
108E2F1_18555785_ChIP-Seq_MESCs_Mouse1.21090500
109HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.19182988
110CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.18480051
111SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.18351012
112KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.17425494
113SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.17320803
114ESR1_15608294_ChIP-ChIP_MCF-7_Human1.16154191
115HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.14645584
116TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14015769
117LXR_22158963_ChIP-Seq_LIVER_Mouse1.13499250
118BCOR_27268052_Chip-Seq_Bcells_Human1.13210888
119* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.13047674
120DNAJC2_21179169_ChIP-ChIP_NT2_Human1.11286214
121IRF1_19129219_ChIP-ChIP_H3396_Human1.11007722
122KLF4_18555785_ChIP-Seq_MESCs_Mouse1.10477350
123ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.10320791
124SOX2_16153702_ChIP-ChIP_HESCs_Human1.10284404
125MYCN_18555785_ChIP-Seq_MESCs_Mouse1.10191263
126UBF1/2_26484160_Chip-Seq_HMECs_Human1.09978215
127CTCF_18555785_ChIP-Seq_MESCs_Mouse1.08560626
128CTCF_26484167_Chip-Seq_Bcells_Mouse1.05688222
129P63_26484246_Chip-Seq_KERATINOCYTES_Human1.05641921
130CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.05308765
131GATA1_22383799_ChIP-Seq_G1ME_Mouse1.05306119
132SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.05246540
133XRN2_22483619_ChIP-Seq_HELA_Human1.04928778
134SA1_27219007_Chip-Seq_Bcells_Human1.04792795
135RARB_24833708_ChIP-Seq_LIVER_Mouse1.03829732
136IKZF1_21737484_ChIP-ChIP_HCT116_Human1.03771074
137CTCF_20526341_ChIP-Seq_ESCs_Human1.03567791
138TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03329194
139EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02425774
140SRY_22984422_ChIP-ChIP_TESTIS_Rat1.02053643
141ELF1_20517297_ChIP-Seq_JURKAT_Human1.01719275
142NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.01041012
143VDR_22108803_ChIP-Seq_LS180_Human1.00929362
144NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.00348334
145ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.99995529
146PU.1_20513432_ChIP-Seq_Bcells_Mouse0.99834587
147BRD4_27068464_Chip-Seq_AML-cells_Mouse0.99702105
148GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.98701465
149MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.98178986
150AR_21909140_ChIP-Seq_LNCAP_Human0.97335475
151SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.97288859
152EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.96977752
153CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.96888042
154* SMC4_20622854_ChIP-Seq_HELA_Human0.96492378
155TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95869968
156CTCF_27219007_Chip-Seq_Bcells_Human0.95511027
157DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.95462483
158* SMC3_22415368_ChIP-Seq_MEFs_Mouse0.95362797
159HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.95270450
160SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.95065272
161GATA1_19941827_ChIP-Seq_MEL_Mouse0.94832242
162RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94693600
163THAP11_20581084_ChIP-Seq_MESCs_Mouse0.94215434
164TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.93435021
165CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.93334484
166WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.92613169
167SOX17_20123909_ChIP-Seq_XEN_Mouse0.88683584
168FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.88437776
169TP53_22127205_ChIP-Seq_IMR90_Human0.85743475
170RING1B_27294783_Chip-Seq_NPCs_Mouse0.84573059
171MYC_22102868_ChIP-Seq_BL_Human0.84530560
172LXR_22292898_ChIP-Seq_THP-1_Human0.83643546
173TP53_23651856_ChIP-Seq_MEFs_Mouse0.82490789
174TP63_19390658_ChIP-ChIP_HaCaT_Human0.79849090
175CREB1_15753290_ChIP-ChIP_HEK293T_Human0.79770481
176RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.79293903
177TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.79068716

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005171_absent_coat_pigmentation7.69675906
2MP0000372_irregular_coat_pigmentation6.55092813
3MP0002697_abnormal_eye_size6.50388214
4MP0005408_hypopigmentation6.01096492
5MP0009780_abnormal_chondrocyte_physiolo5.87631294
6MP0005075_abnormal_melanosome_morpholog5.78946170
7MP0002877_abnormal_melanocyte_morpholog5.72782379
8MP0005257_abnormal_intraocular_pressure3.93345149
9MP0004858_abnormal_nervous_system3.91374447
10MP0005193_abnormal_anterior_eye3.89212219
11MP0000015_abnormal_ear_pigmentation3.79562435
12MP0005174_abnormal_tail_pigmentation3.74073402
13MP0004381_abnormal_hair_follicle3.49009662
14MP0002095_abnormal_skin_pigmentation3.30298993
15MP0004147_increased_porphyrin_level3.17720099
16MP0002938_white_spotting3.14172070
17MP0009384_cardiac_valve_regurgitation2.88692479
18MP0005058_abnormal_lysosome_morphology2.86616118
19MP0000371_diluted_coat_color2.86584889
20MP0003941_abnormal_skin_development2.77136695
21MP0002653_abnormal_ependyma_morphology2.70960682
22MP0003172_abnormal_lysosome_physiology2.69038736
23MP0008057_abnormal_DNA_replication2.55644417
24MP0005623_abnormal_meninges_morphology2.37644432
25MP0002075_abnormal_coat/hair_pigmentati2.36452936
26MP0005253_abnormal_eye_physiology2.34533830
27MP0003119_abnormal_digestive_system2.30425619
28MP0001188_hyperpigmentation2.25647038
29MP0003136_yellow_coat_color2.23977249
30MP0004272_abnormal_basement_membrane2.18713311
31MP0001286_abnormal_eye_development2.18119157
32MP0001324_abnormal_eye_pigmentation2.18103796
33MP0010030_abnormal_orbit_morphology2.12333461
34MP0005646_abnormal_pituitary_gland2.09911111
35MP0006292_abnormal_olfactory_placode1.97038506
36MP0003705_abnormal_hypodermis_morpholog1.93383817
37MP0009053_abnormal_anal_canal1.92285911
38MP0003279_aneurysm1.87408100
39MP0001186_pigmentation_phenotype1.83010332
40MP0004957_abnormal_blastocyst_morpholog1.81065408
41MP0002092_abnormal_eye_morphology1.81029581
42MP0005197_abnormal_uvea_morphology1.77321717
43MP0000049_abnormal_middle_ear1.73496546
44MP0002822_catalepsy1.71303506
45MP0005391_vision/eye_phenotype1.65145865
46MP0004133_heterotaxia1.63880953
47MP0008438_abnormal_cutaneous_collagen1.58702932
48MP0001915_intracranial_hemorrhage1.58559702
49MP0000750_abnormal_muscle_regeneration1.58439148
50MP0003938_abnormal_ear_development1.45789619
51MP0005248_abnormal_Harderian_gland1.38979668
52MP0002796_impaired_skin_barrier1.31336542
53MP0003718_maternal_effect1.31165795
54MP0002249_abnormal_larynx_morphology1.28424346
55MP0002084_abnormal_developmental_patter1.27812962
56MP0000749_muscle_degeneration1.27512306
57MP0001346_abnormal_lacrimal_gland1.26765071
58MP0003123_paternal_imprinting1.24837105
59MP0003137_abnormal_impulse_conducting1.22613309
60MP0003011_delayed_dark_adaptation1.22541911
61MP0003806_abnormal_nucleotide_metabolis1.21917421
62MP0001348_abnormal_lacrimal_gland1.20850437
63MP0005501_abnormal_skin_physiology1.20346803
64MP0004197_abnormal_fetal_growth/weight/1.20308833
65MP0001440_abnormal_grooming_behavior1.19459941
66MP0005377_hearing/vestibular/ear_phenot1.18580562
67MP0003878_abnormal_ear_physiology1.18580562
68MP0000428_abnormal_craniofacial_morphol1.16728896
69MP0005451_abnormal_body_composition1.16495866
70MP0000537_abnormal_urethra_morphology1.15253028
71MP0000579_abnormal_nail_morphology1.14022105
72MP0002269_muscular_atrophy1.13614385
73MP0001853_heart_inflammation1.13599970
74MP0000920_abnormal_myelination1.07395322
75MP0002090_abnormal_vision1.06985750
76MP0001672_abnormal_embryogenesis/_devel1.05989964
77MP0005380_embryogenesis_phenotype1.05989964
78MP0009840_abnormal_foam_cell1.05938349
79MP0003690_abnormal_glial_cell1.05067955
80MP0001730_embryonic_growth_arrest1.05040981
81MP0003942_abnormal_urinary_system1.03655614
82MP0002085_abnormal_embryonic_tissue1.03242153
83MP0003566_abnormal_cell_adhesion1.03195770
84MP0010352_gastrointestinal_tract_polyps1.02916893
85MP0010094_abnormal_chromosome_stability1.02475251
86MP0004233_abnormal_muscle_weight1.01921468
87MP0000569_abnormal_digit_pigmentation1.01480203
88MP0008569_lethality_at_weaning1.00275751
89MP0002086_abnormal_extraembryonic_tissu0.98195831
90MP0005499_abnormal_olfactory_system0.97051700
91MP0005394_taste/olfaction_phenotype0.97051700
92MP0002102_abnormal_ear_morphology0.96613536
93MP0000566_synostosis0.95467625
94MP0004264_abnormal_extraembryonic_tissu0.94926720
95MP0008789_abnormal_olfactory_epithelium0.94261849
96MP0003077_abnormal_cell_cycle0.93995592
97MP0000467_abnormal_esophagus_morphology0.93513223
98MP0003880_abnormal_central_pattern0.93266670
99MP0002111_abnormal_tail_morphology0.90111024
100MP0004885_abnormal_endolymph0.90072793
101MP0003634_abnormal_glial_cell0.88866471
102MP0003111_abnormal_nucleus_morphology0.87878190
103MP0002282_abnormal_trachea_morphology0.87112193
104MP0000639_abnormal_adrenal_gland0.86974836
105MP0001697_abnormal_embryo_size0.86119854
106MP0003936_abnormal_reproductive_system0.85261427
107MP0003861_abnormal_nervous_system0.85239997
108MP0005187_abnormal_penis_morphology0.83070306
109MP0005409_darkened_coat_color0.82453040
110MP0000762_abnormal_tongue_morphology0.82400622
111MP0003984_embryonic_growth_retardation0.81215475
112MP0006072_abnormal_retinal_apoptosis0.80825816
113MP0003755_abnormal_palate_morphology0.80727909
114MP0002088_abnormal_embryonic_growth/wei0.80547635
115MP0002089_abnormal_postnatal_growth/wei0.80543899
116MP0005670_abnormal_white_adipose0.79348922
117MP0000350_abnormal_cell_proliferation0.79331145
118MP0003183_abnormal_peptide_metabolism0.79123068
119MP0008260_abnormal_autophagy0.78429056
120MP0001293_anophthalmia0.78174427
121MP0003693_abnormal_embryo_hatching0.78121915
122MP0001542_abnormal_bone_strength0.77441191
123MP0002909_abnormal_adrenal_gland0.76995565
124MP0002127_abnormal_cardiovascular_syste0.76346097
125MP0002116_abnormal_craniofacial_bone0.76088496
126MP0003879_abnormal_hair_cell0.75236250
127MP0003283_abnormal_digestive_organ0.75115803
128MP0000432_abnormal_head_morphology0.75019600
129MP0005671_abnormal_response_to0.73270583
130MP0001849_ear_inflammation0.73158093
131MP0002160_abnormal_reproductive_system0.72976443
132MP0005508_abnormal_skeleton_morphology0.72393007
133MP0001485_abnormal_pinna_reflex0.71011826
134MP0003890_abnormal_embryonic-extraembry0.69715933
135MP0004043_abnormal_pH_regulation0.69233610
136MP0008932_abnormal_embryonic_tissue0.68420396
137MP0004019_abnormal_vitamin_homeostasis0.68304259
138MP0003632_abnormal_nervous_system0.67802327
139MP0003935_abnormal_craniofacial_develop0.67310788
140MP0008007_abnormal_cellular_replicative0.66289398
141MP0000343_altered_response_to0.65155155
142MP0003315_abnormal_perineum_morphology0.63606905
143MP0003959_abnormal_lean_body0.63222396
144MP0003638_abnormal_response/metabolism_0.61716621
145MP0001270_distended_abdomen0.57969996
146MP0010386_abnormal_urinary_bladder0.52440165
147MP0000367_abnormal_coat/_hair0.49959899
148MP0002177_abnormal_outer_ear0.46449765
149MP0002229_neurodegeneration0.46034217
150MP0001501_abnormal_sleep_pattern0.44998373
151MP0002998_abnormal_bone_remodeling0.44806575
152MP0000462_abnormal_digestive_system0.43085052
153MP0003186_abnormal_redox_activity0.40893008
154MP0003646_muscle_fatigue0.38509251
155MP0006138_congestive_heart_failure0.35859531
156MP0000534_abnormal_ureter_morphology0.33249325
157MP0001502_abnormal_circadian_rhythm0.32381585
158MP0002735_abnormal_chemical_nociception0.31519311
159MP0000003_abnormal_adipose_tissue0.30527638
160MP0000013_abnormal_adipose_tissue0.30051253
161MP0008875_abnormal_xenobiotic_pharmacok0.29858968
162MP0000358_abnormal_cell_content/0.29263592
163MP0002557_abnormal_social/conspecific_i0.28402211
164MP0003329_amyloid_beta_deposits0.27153647
165MP0009643_abnormal_urine_homeostasis0.26870850
166MP0005584_abnormal_enzyme/coenzyme_acti0.26373614
167MP0001851_eye_inflammation0.24140838
168MP0001963_abnormal_hearing_physiology0.22838546
169MP0010329_abnormal_lipoprotein_level0.22707477
170MP0005266_abnormal_metabolism0.22303841
171MP0008770_decreased_survivor_rate0.21337953
172MP0001919_abnormal_reproductive_system0.20592314
173MP0002638_abnormal_pupillary_reflex0.19937788
174MP0002106_abnormal_muscle_physiology0.19092206
175MP0003953_abnormal_hormone_level0.18327270
176MP0005384_cellular_phenotype0.17862116
177MP0000604_amyloidosis0.17232018

Predicted human phenotypes

RankGene SetZ-score
1Ocular albinism (HP:0001107)7.22574079
2Blue irides (HP:0000635)6.43389827
3Iris hypopigmentation (HP:0007730)6.21361947
4Heterochromia iridis (HP:0001100)5.94715409
5Hypoplasia of the fovea (HP:0007750)5.76684268
6Aplasia/Hypoplasia of the fovea (HP:0008060)5.76684268
7Amblyopia (HP:0000646)5.41070934
8Abnormality of glycolipid metabolism (HP:0010969)5.08501913
9Abnormality of liposaccharide metabolism (HP:0010968)5.08501913
10Abnormality of glycosphingolipid metabolism (HP:0004343)5.08501913
11Congenital cataract (HP:0000519)4.83868674
12Hypopigmentation of the fundus (HP:0007894)4.83756638
13Corneal dystrophy (HP:0001131)4.81080443
14Selective tooth agenesis (HP:0001592)4.77066063
15Abnormality of the fovea (HP:0000493)4.68915458
16Aplasia involving bones of the extremities (HP:0009825)4.48341706
17Aplasia involving bones of the upper limbs (HP:0009823)4.48341706
18Aplasia of the phalanges of the hand (HP:0009802)4.48341706
19Broad alveolar ridges (HP:0000187)4.32881856
20Generalized hypopigmentation (HP:0007513)4.27220665
21Abnormal auditory evoked potentials (HP:0006958)4.23356637
22Increased cerebral lipofuscin (HP:0011813)4.14555872
23Peripheral hypomyelination (HP:0007182)3.95462274
24Anterior segment dysgenesis (HP:0007700)3.93064189
25Esophageal neoplasm (HP:0100751)3.89995979
26Neoplasm of head and neck (HP:0012288)3.89995979
27Short middle phalanx of the 5th finger (HP:0004220)3.87695527
28Loss of speech (HP:0002371)3.74251743
29Dry hair (HP:0011359)3.73731227
30Hypoplasia of the iris (HP:0007676)3.72337370
31Albinism (HP:0001022)3.58968345
32Paraparesis (HP:0002385)3.56402535
33Spastic paraparesis (HP:0002313)3.54544908
34Increased neuronal autofluorescent lipopigment (HP:0002074)3.53148628
35Premature graying of hair (HP:0002216)3.52605094
36Tetraparesis (HP:0002273)3.50236670
37Rib fusion (HP:0000902)3.29974411
38Abnormal gallbladder physiology (HP:0012438)3.27434937
39Cholecystitis (HP:0001082)3.27434937
40Long nose (HP:0003189)3.19022079
41Hypoplastic heart (HP:0001961)3.08581034
42Bilateral sensorineural hearing impairment (HP:0008619)3.08221441
43Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.05585176
44Hypoplastic left heart (HP:0004383)3.03444889
45Gastrointestinal stroma tumor (HP:0100723)3.02464294
46Clumsiness (HP:0002312)2.89565594
47Vertebral compression fractures (HP:0002953)2.85637774
48J-shaped sella turcica (HP:0002680)2.83907218
49Microcornea (HP:0000482)2.76398103
50Dysostosis multiplex (HP:0000943)2.71722224
51Aplasia/Hypoplasia of the hallux (HP:0008362)2.70133277
52Short hallux (HP:0010109)2.70114555
53Polar cataract (HP:0010696)2.68015591
54Abnormality of the alveolar ridges (HP:0006477)2.66516876
55Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.62012205
56Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.61758267
57Maternal diabetes (HP:0009800)2.60872548
58Fragile nails (HP:0001808)2.57407478
59Cerebral aneurysm (HP:0004944)2.56192039
60Alacrima (HP:0000522)2.53382027
61Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.50198466
62Short 5th finger (HP:0009237)2.48506510
63Abnormality of the columella (HP:0009929)2.47074171
64Neurofibrillary tangles (HP:0002185)2.46745264
65Systemic lupus erythematosus (HP:0002725)2.46150188
66Supernumerary spleens (HP:0009799)2.43655219
67Fused cervical vertebrae (HP:0002949)2.39221330
68Cerebral inclusion bodies (HP:0100314)2.38276327
69Abnormality of the phalanges of the 5th finger (HP:0004213)2.35628509
70Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.31506326
71Asymmetric septal hypertrophy (HP:0001670)2.29718674
72Purpura (HP:0000979)2.26360087
73Congenital sensorineural hearing impairment (HP:0008527)2.26298988
74Abnormality of chromosome segregation (HP:0002916)2.24145593
75Iris coloboma (HP:0000612)2.19669128
76Gonadal dysgenesis (HP:0000133)2.17341571
77Germ cell neoplasia (HP:0100728)2.16802270
78Cortical dysplasia (HP:0002539)2.14594689
79Birth length less than 3rd percentile (HP:0003561)2.12934938
80Sclerocornea (HP:0000647)2.12839545
81Freckling (HP:0001480)2.10734191
82Abnormality of the labia minora (HP:0012880)2.10048562
83Synophrys (HP:0000664)2.09716567
84Aplasia of the musculature (HP:0100854)2.08561738
85Cerebral hypomyelination (HP:0006808)2.06881367
86Abnormality of mucopolysaccharide metabolism (HP:0011020)2.05993887
87Abnormality of polysaccharide metabolism (HP:0011012)2.05993887
88Abnormality of glycosaminoglycan metabolism (HP:0004371)2.05993887
89Mixed hearing impairment (HP:0000410)2.05390138
90Atrioventricular block (HP:0001678)2.04894386
91Short palpebral fissure (HP:0012745)2.03292344
92Nuclear cataract (HP:0100018)18.2360891
93Zonular cataract (HP:0010920)15.9559122
94White forelock (HP:0002211)11.2131005
95Patchy hypopigmentation of hair (HP:0011365)10.2431292
96Median cleft lip (HP:0000161)1.98251579
97Aplasia/Hypoplasia of the macula (HP:0008059)1.98006026
98Hand muscle atrophy (HP:0009130)1.97391913
99Prolonged neonatal jaundice (HP:0006579)1.97257729
100Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.96438556
101Morphological abnormality of the inner ear (HP:0011390)1.95990586
102Missing ribs (HP:0000921)1.95814457
103Abnormal number of incisors (HP:0011064)1.95637791
104Esophageal atresia (HP:0002032)1.87397378
105Anosmia (HP:0000458)1.86278810
106Urinary glycosaminoglycan excretion (HP:0003541)1.86020413
107Mucopolysacchariduria (HP:0008155)1.86020413
108Achilles tendon contracture (HP:0001771)1.85042853
109Neoplasm of the peripheral nervous system (HP:0100007)1.83892651
110Supranuclear gaze palsy (HP:0000605)1.83693781
111Decreased lacrimation (HP:0000633)1.83534518
112Premature loss of primary teeth (HP:0006323)1.83162664
113Generalized hypopigmentation of hair (HP:0011358)1.82909002
114Short humerus (HP:0005792)1.82569646
115Absent toe (HP:0010760)1.81141949
116Upper limb muscle weakness (HP:0003484)1.80916599
117Astrocytoma (HP:0009592)1.79380531
118Abnormality of the astrocytes (HP:0100707)1.79380531
119Aplasia/hypoplasia of the humerus (HP:0006507)1.79220596
120Ependymoma (HP:0002888)1.79107626
121Narrow nasal bridge (HP:0000446)1.77512123
122Peripheral demyelination (HP:0011096)1.77355811
123Hypoplasia of the capital femoral epiphysis (HP:0003090)1.76521880
124Aplasia/Hypoplasia affecting the retina (HP:0008061)1.74006306
125Atrioventricular canal defect (HP:0006695)1.73754155
126Opacification of the corneal stroma (HP:0007759)1.73330238
127Cutaneous melanoma (HP:0012056)1.72108069
128Segmental peripheral demyelination/remyelination (HP:0003481)1.72078109
129Abnormality of glycolysis (HP:0004366)1.70557016
130Abnormality of the Achilles tendon (HP:0005109)1.65841044
131Absent forearm bone (HP:0003953)1.65633910
132Aplasia involving forearm bones (HP:0009822)1.65633910
133Facial cleft (HP:0002006)1.65115308
134Upper limb amyotrophy (HP:0009129)1.64804849
135Distal upper limb amyotrophy (HP:0007149)1.64804849
136Breast hypoplasia (HP:0003187)1.64561829
137Aplasia/Hypoplasia of the spleen (HP:0010451)1.64248858
138Proximal amyotrophy (HP:0007126)1.63377601
139Hypokinesia (HP:0002375)1.62035468
140Protrusio acetabuli (HP:0003179)1.61250488
141Absent radius (HP:0003974)1.60479055
142Abnormal autonomic nervous system physiology (HP:0012332)1.60179324
143Aplasia/Hypoplasia involving the musculature (HP:0001460)1.59764940
144Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.59146516
145Absent epiphyses (HP:0010577)1.59146516
146Abnormality of vision evoked potentials (HP:0000649)1.58803191
147Petechiae (HP:0000967)1.58218595
148Erectile abnormalities (HP:0100639)1.57698750
149Abnormality of the anterior chamber (HP:0000593)1.56553706
150Abnormality of the lower motor neuron (HP:0002366)1.56095483
151Abnormality of the metopic suture (HP:0005556)1.55197084
152Erythema (HP:0010783)1.54836540
153Prominent metopic ridge (HP:0005487)1.54269048
154Sex reversal (HP:0012245)1.53554912
155Abnormal sex determination (HP:0012244)1.53554912
156Global brain atrophy (HP:0002283)1.53485260
157Retinal atrophy (HP:0001105)1.52918559
158Hypoalphalipoproteinemia (HP:0003233)1.52904057
159Popliteal pterygium (HP:0009756)1.52787337
160Asplenia (HP:0001746)1.52615453
161Hyperacusis (HP:0010780)1.52559743
162Pterygium (HP:0001059)1.51832603
163Cutaneous syndactyly (HP:0012725)1.48102805
164Decreased motor nerve conduction velocity (HP:0003431)1.46625323
165Abnormality of the dental root (HP:0006486)1.45804806
166Taurodontia (HP:0000679)1.45804806
167Abnormality of permanent molar morphology (HP:0011071)1.45804806
168Deep venous thrombosis (HP:0002625)1.45801894
169Xanthomatosis (HP:0000991)1.45185088
170Cubitus valgus (HP:0002967)1.44824484
171Abnormality of aromatic amino acid family metabolism (HP:0004338)1.43452433
172Akinesia (HP:0002304)1.42577294
173Axonal loss (HP:0003447)1.42574601
174Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.42291657
175Natal tooth (HP:0000695)1.42146368
176Deformed sella turcica (HP:0002681)1.41627392
177Distal sensory impairment (HP:0002936)1.41586288
178Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)1.41215121
179Rectovaginal fistula (HP:0000143)1.40740780
180Rectal fistula (HP:0100590)1.40740780
181Spinal muscular atrophy (HP:0007269)1.40495330
182Patellar aplasia (HP:0006443)1.39596428
183Alopecia of scalp (HP:0002293)1.39575270
184Vertebral clefting (HP:0008428)1.39270785
185Thin ribs (HP:0000883)1.39049251
186Abnormality of the aortic arch (HP:0012303)1.39012564
187Adrenal hypoplasia (HP:0000835)1.36960983
188Hyperlipoproteinemia (HP:0010980)1.36767427
189Thyroid-stimulating hormone excess (HP:0002925)1.36641490
190Preaxial foot polydactyly (HP:0001841)1.35627439
191Facial hemangioma (HP:0000329)1.34776424
192Abnormality of the dental pulp (HP:0006479)1.34613825
193Vertebral fusion (HP:0002948)1.34386987

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KIT4.98772241
2CDC74.70206386
3MAP3K94.13983862
4MAP3K33.44640766
5PINK13.39348257
6CDK123.32288772
7NEK62.79339180
8NEK12.75597882
9PDK22.70874362
10LMTK22.57545469
11CDK62.51164823
12MAPK72.35910587
13MARK32.28807573
14MAPK122.27931949
15SIK12.26883873
16PRKD32.26823941
17LATS22.14557819
18MAPKAPK32.00145924
19NME21.92379342
20EPHA21.85871777
21TYRO31.85006095
22SIK21.82215069
23MAP2K61.81373115
24MAP3K21.77929899
25AKT31.57022318
26ICK1.56464306
27PAK41.55524491
28DDR21.54283007
29UHMK11.53335634
30MST1R1.52296593
31EEF2K1.47625052
32FGR1.47255787
33BCKDK1.46009629
34CDK41.45096166
35WNK41.40094762
36CDK71.37717182
37PLK11.30529945
38WEE11.28290874
39PIM21.26618340
40BCR1.26092471
41PRKCG1.25912191
42LRRK21.25859988
43TTK1.24659642
44MET1.20297734
45PKN21.19071436
46MAP3K101.18798927
47ALK1.17902830
48SIK31.14906609
49CDK31.10276794
50ACVR1B1.08498191
51DYRK21.08282191
52ERBB41.08045914
53ERN11.07472554
54DYRK1B1.07370287
55MAP4K11.06201853
56EPHA41.00883114
57RPS6KB20.98442359
58FGFR40.97371853
59BMX0.96595116
60DAPK10.96073190
61CDK150.95801626
62PRPF4B0.94804073
63MARK10.93378152
64NTRK30.92905950
65SGK10.92356157
66AURKA0.90623102
67PDPK10.89751359
68TAOK10.89740440
69PDGFRA0.89540077
70CDK180.89347236
71CDK11A0.89011030
72CDK140.87864984
73GSK3A0.87332843
74MATK0.87040622
75BRD40.86660258
76CHEK10.86512230
77YES10.84742892
78TBK10.84168438
79MAP3K110.83480476
80CDK20.82639204
81MAPK110.82383661
82CHEK20.81989905
83RIPK10.81937382
84NTRK10.81319226
85RPS6KA20.81019250
86PTK60.80972739
87PAK30.77564578
88MTOR0.72963228
89STK100.72637893
90CSNK1E0.72277913
91MELK0.71170017
92TESK20.71046682
93MAPK130.70125695
94MAPK100.69747051
95IGF1R0.69399615
96ABL20.69332167
97BRSK10.68491774
98WNK10.66940127
99NTRK20.66614158
100PRKCI0.66196168
101PRKCH0.65143814
102KDR0.64702951
103CSNK2A20.64431840
104FGFR10.62748090
105CSNK1D0.62156045
106PTK20.60376560
107PRKD10.59779212
108DYRK30.58662641
109TRIB30.58383523
110SCYL20.57493084
111AURKB0.55848610
112MAP3K80.55578594
113CDK10.54711344
114MAPK10.54019573
115PRKAA20.53799994
116TAOK20.53414860
117PRKACB0.52847335
118AKT20.51764606
119PDK10.51482128
120GRK10.51479559
121PAK10.51054827
122PRKCB0.51037509
123CCNB10.50145374
124MAP3K10.49981163
125NEK90.49596205
126MAP3K60.49235064
127MAPK40.48638616
128MAPK140.48633487
129BUB10.48145105
130MAPK90.47965448
131RPS6KB10.46830982
132PRKG10.46740610
133DAPK30.46656097
134ADRBK10.46585263
135NEK20.45684087
136CDC42BPA0.45354965
137INSR0.44478240
138PLK30.44295645
139GSK3B0.44169675
140PHKG20.44158234
141PHKG10.44158234
142FER0.43502940
143CSNK1G30.42626506
144CSNK1A1L0.42372544
145CSNK1G20.40084051
146PAK20.35459262
147FYN0.35058878
148EIF2AK10.33412365
149GRK60.31418199
150PRKD20.28460563
151MARK20.28135057
152PTK2B0.27134946
153MAPK30.23933141
154ZAP700.21151763
155CSNK1G10.20590787
156AKT10.19149906
157EPHB10.18620400
158RET0.18597693
159MAP2K30.18220342
160LYN0.17924351
161STK160.16917476
162CHUK0.16823456
163FGFR30.15755446
164MAP2K20.15603782

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005113.75205268
2Glycosaminoglycan degradation_Homo sapiens_hsa005313.61528111
3Lysosome_Homo sapiens_hsa041423.54980390
4DNA replication_Homo sapiens_hsa030303.38980023
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.23434332
6Mismatch repair_Homo sapiens_hsa034303.21469536
7One carbon pool by folate_Homo sapiens_hsa006703.07601586
8Cyanoamino acid metabolism_Homo sapiens_hsa004602.92960425
9Basal cell carcinoma_Homo sapiens_hsa052172.72051474
10Pentose phosphate pathway_Homo sapiens_hsa000302.70143323
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.69804246
12Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002502.43853074
13RNA transport_Homo sapiens_hsa030132.40780011
14Hedgehog signaling pathway_Homo sapiens_hsa043402.39111501
15Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.23647785
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.18816318
17Nucleotide excision repair_Homo sapiens_hsa034202.18001533
18Lysine degradation_Homo sapiens_hsa003102.16174698
19Cell cycle_Homo sapiens_hsa041102.02970221
20Hippo signaling pathway_Homo sapiens_hsa043902.02170838
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.00645236
22Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.94821719
23Starch and sucrose metabolism_Homo sapiens_hsa005001.86618468
24Base excision repair_Homo sapiens_hsa034101.86172366
25Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.81232047
26Collecting duct acid secretion_Homo sapiens_hsa049661.77703695
27Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.75605244
28Biosynthesis of amino acids_Homo sapiens_hsa012301.75263875
29mRNA surveillance pathway_Homo sapiens_hsa030151.71367616
30Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.68625002
31Arginine and proline metabolism_Homo sapiens_hsa003301.61948821
32Non-homologous end-joining_Homo sapiens_hsa034501.60799978
33Ribosome_Homo sapiens_hsa030101.60238431
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.59920238
35p53 signaling pathway_Homo sapiens_hsa041151.57218956
36Histidine metabolism_Homo sapiens_hsa003401.56872437
37Ovarian steroidogenesis_Homo sapiens_hsa049131.56236723
38* Small cell lung cancer_Homo sapiens_hsa052221.48161156
39Spliceosome_Homo sapiens_hsa030401.47630789
40Fatty acid elongation_Homo sapiens_hsa000621.45335499
41Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.43972063
42Vibrio cholerae infection_Homo sapiens_hsa051101.43830599
43Pentose and glucuronate interconversions_Homo sapiens_hsa000401.40230293
44Fructose and mannose metabolism_Homo sapiens_hsa000511.38793029
45Adherens junction_Homo sapiens_hsa045201.36468592
46Thyroid hormone signaling pathway_Homo sapiens_hsa049191.32224102
47Wnt signaling pathway_Homo sapiens_hsa043101.28931019
48mTOR signaling pathway_Homo sapiens_hsa041501.28880608
49Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.27738447
50Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.26151521
51Sulfur relay system_Homo sapiens_hsa041221.24863674
52Gap junction_Homo sapiens_hsa045401.24633618
53Sphingolipid metabolism_Homo sapiens_hsa006001.23645487
54Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.15828809
55Fatty acid biosynthesis_Homo sapiens_hsa000611.09558674
56Tyrosine metabolism_Homo sapiens_hsa003501.07475954
57Oxidative phosphorylation_Homo sapiens_hsa001901.04643658
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.03346346
59Tight junction_Homo sapiens_hsa045301.03332957
60Proteoglycans in cancer_Homo sapiens_hsa052051.01894909
61Drug metabolism - other enzymes_Homo sapiens_hsa009831.01291466
62Galactose metabolism_Homo sapiens_hsa000520.98977754
63Acute myeloid leukemia_Homo sapiens_hsa052210.95758890
64Phagosome_Homo sapiens_hsa041450.94710857
65Central carbon metabolism in cancer_Homo sapiens_hsa052300.94628644
66ECM-receptor interaction_Homo sapiens_hsa045120.92766081
67Melanogenesis_Homo sapiens_hsa049160.90440658
68Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.88650982
69Rheumatoid arthritis_Homo sapiens_hsa053230.88321176
70Bladder cancer_Homo sapiens_hsa052190.84915183
71Pyrimidine metabolism_Homo sapiens_hsa002400.83850802
72Allograft rejection_Homo sapiens_hsa053300.83548788
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.82275017
74TGF-beta signaling pathway_Homo sapiens_hsa043500.82099954
75Basal transcription factors_Homo sapiens_hsa030220.79884639
76* Pathways in cancer_Homo sapiens_hsa052000.79135899
77Cysteine and methionine metabolism_Homo sapiens_hsa002700.78860128
78RNA polymerase_Homo sapiens_hsa030200.78743379
79Prion diseases_Homo sapiens_hsa050200.78553989
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.77935370
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77688731
82Oocyte meiosis_Homo sapiens_hsa041140.77080492
83Autoimmune thyroid disease_Homo sapiens_hsa053200.76743645
84N-Glycan biosynthesis_Homo sapiens_hsa005100.76707441
85Steroid hormone biosynthesis_Homo sapiens_hsa001400.75785432
86Notch signaling pathway_Homo sapiens_hsa043300.74298435
87Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.72202840
88* Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72018912
89Inositol phosphate metabolism_Homo sapiens_hsa005620.71749802
90Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.70870470
91Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.70720623
92Carbon metabolism_Homo sapiens_hsa012000.70150281
93Steroid biosynthesis_Homo sapiens_hsa001000.68921402
94Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67600780
95Vitamin B6 metabolism_Homo sapiens_hsa007500.66570958
96Folate biosynthesis_Homo sapiens_hsa007900.66326668
97PI3K-Akt signaling pathway_Homo sapiens_hsa041510.64677877
98Proteasome_Homo sapiens_hsa030500.63131155
99Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.62988416
100Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.62928010
101MicroRNAs in cancer_Homo sapiens_hsa052060.62144474
102Graft-versus-host disease_Homo sapiens_hsa053320.60987910
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.59861156
104Arginine biosynthesis_Homo sapiens_hsa002200.59676239
105Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58061678
106Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57187355
107Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.55179692
108Focal adhesion_Homo sapiens_hsa045100.53984713
109Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53598402
110Homologous recombination_Homo sapiens_hsa034400.53322307
111Endocytosis_Homo sapiens_hsa041440.50123949
112Parkinsons disease_Homo sapiens_hsa050120.48872745
113Vitamin digestion and absorption_Homo sapiens_hsa049770.48022588
114ErbB signaling pathway_Homo sapiens_hsa040120.47874214
115Insulin resistance_Homo sapiens_hsa049310.47762398
116Alzheimers disease_Homo sapiens_hsa050100.47129047
117Prostate cancer_Homo sapiens_hsa052150.47120397
118Antigen processing and presentation_Homo sapiens_hsa046120.46583172
119Pyruvate metabolism_Homo sapiens_hsa006200.45878048
120Cardiac muscle contraction_Homo sapiens_hsa042600.45685605
121Insulin signaling pathway_Homo sapiens_hsa049100.45372417
122Thyroid cancer_Homo sapiens_hsa052160.44586254
123Complement and coagulation cascades_Homo sapiens_hsa046100.43880324
124Mineral absorption_Homo sapiens_hsa049780.43630333
125Staphylococcus aureus infection_Homo sapiens_hsa051500.43441886
126Fanconi anemia pathway_Homo sapiens_hsa034600.43366475
127Glutathione metabolism_Homo sapiens_hsa004800.43356818
128Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.41969427
129Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41420996
130Synaptic vesicle cycle_Homo sapiens_hsa047210.41417554
131Dilated cardiomyopathy_Homo sapiens_hsa054140.39510104
132Primary bile acid biosynthesis_Homo sapiens_hsa001200.39385368
133Rap1 signaling pathway_Homo sapiens_hsa040150.38938038
134Circadian rhythm_Homo sapiens_hsa047100.38583741
135Bile secretion_Homo sapiens_hsa049760.38320094
136Carbohydrate digestion and absorption_Homo sapiens_hsa049730.37600853
137ABC transporters_Homo sapiens_hsa020100.37262844
138AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.37141777
139Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.36536663
140Amoebiasis_Homo sapiens_hsa051460.36360263
141Fatty acid metabolism_Homo sapiens_hsa012120.35694841
142Adipocytokine signaling pathway_Homo sapiens_hsa049200.35653865
143Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.35439462
144Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.35259774
145Ether lipid metabolism_Homo sapiens_hsa005650.33224537
146RNA degradation_Homo sapiens_hsa030180.32991996
147Butanoate metabolism_Homo sapiens_hsa006500.32792749
148Protein digestion and absorption_Homo sapiens_hsa049740.32527713
149Type I diabetes mellitus_Homo sapiens_hsa049400.32221383
150Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.32120355
151Longevity regulating pathway - mammal_Homo sapiens_hsa042110.31683834
152HTLV-I infection_Homo sapiens_hsa051660.31298692
153Viral myocarditis_Homo sapiens_hsa054160.30658814
154AMPK signaling pathway_Homo sapiens_hsa041520.28766871
155Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.28667160
156Renin-angiotensin system_Homo sapiens_hsa046140.28644211
157Phenylalanine metabolism_Homo sapiens_hsa003600.27961334
158beta-Alanine metabolism_Homo sapiens_hsa004100.26821600
159Chemical carcinogenesis_Homo sapiens_hsa052040.26630895
160Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.26601980
161HIF-1 signaling pathway_Homo sapiens_hsa040660.26453778
162Metabolic pathways_Homo sapiens_hsa011000.26353948
163Herpes simplex infection_Homo sapiens_hsa051680.26205318
164Melanoma_Homo sapiens_hsa052180.25661798

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