BIRC3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. It contains 3 baculovirus IAP repeats and a ring finger domain. Transcript variants encoding the same isoform have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* NIK/NF-kappaB signaling (GO:0038061)5.12721934
2antigen processing and presentation of endogenous antigen (GO:0019883)5.07785346
3positive regulation of gamma-delta T cell activation (GO:0046645)4.96965479
4positive regulation of immune response to tumor cell (GO:0002839)4.87835334
5regulation of immune response to tumor cell (GO:0002837)4.87835334
6regulation of response to tumor cell (GO:0002834)4.87835334
7positive regulation of response to tumor cell (GO:0002836)4.87835334
8activated T cell proliferation (GO:0050798)4.87460085
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.55455775
10antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.55131213
11antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.55131213
12CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)4.45253116
13regulation of interleukin-12 biosynthetic process (GO:0045075)4.39882926
14positive regulation of natural killer cell mediated immunity (GO:0002717)4.27302414
15negative regulation of interleukin-12 production (GO:0032695)4.26912775
16regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.20814277
17regulation of natural killer cell mediated immunity (GO:0002715)4.20814277
18positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.20426774
19negative regulation of cell killing (GO:0031342)4.19003115
20negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.19003115
21myeloid dendritic cell differentiation (GO:0043011)4.11843101
22myeloid dendritic cell activation (GO:0001773)4.05300273
23response to muramyl dipeptide (GO:0032495)4.01534289
24neutrophil activation involved in immune response (GO:0002283)3.96291265
25immunoglobulin mediated immune response (GO:0016064)3.87950697
26regulation of dendritic cell antigen processing and presentation (GO:0002604)3.86325404
27negative thymic T cell selection (GO:0045060)3.83394724
28cellular response to interleukin-15 (GO:0071350)3.82104236
29positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.79923765
30positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.78510665
31modulation by symbiont of host defense response (GO:0052031)3.77941179
32modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.77941179
33modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.77941179
34positive regulation by organism of defense response of other organism involved in symbiotic interact3.77941179
35modulation by symbiont of host immune response (GO:0052553)3.77941179
36positive regulation by symbiont of host defense response (GO:0052509)3.77941179
37negative regulation of T cell mediated immunity (GO:0002710)3.72272973
38regulation of leukocyte mediated cytotoxicity (GO:0001910)3.71215795
39regulation of gamma-delta T cell activation (GO:0046643)3.66596347
40positive regulation of antigen processing and presentation (GO:0002579)3.66494588
41negative T cell selection (GO:0043383)3.64121785
42regulation of chronic inflammatory response (GO:0002676)3.62684792
43regulation of alpha-beta T cell proliferation (GO:0046640)3.61445457
44positive regulation of humoral immune response (GO:0002922)3.58880900
45positive regulation of cell killing (GO:0031343)3.57174316
46regulation of gamma-delta T cell differentiation (GO:0045586)3.54544495
47regulation of cell killing (GO:0031341)3.54253863
48interferon-gamma-mediated signaling pathway (GO:0060333)3.50095351
49positive regulation of tolerance induction (GO:0002645)3.49360110
50response to peptidoglycan (GO:0032494)3.49234335
51regulation of B cell receptor signaling pathway (GO:0050855)3.49192501
52neutrophil activation (GO:0042119)3.48545458
53positive regulation of interleukin-12 production (GO:0032735)3.48048295
54positive regulation of interleukin-10 production (GO:0032733)3.47510905
55positive thymic T cell selection (GO:0045059)3.45575980
56positive regulation of protein homooligomerization (GO:0032464)3.43708356
57regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.42753885
58natural killer cell mediated cytotoxicity (GO:0042267)3.39230571
59natural killer cell mediated immunity (GO:0002228)3.39230571
60positive regulation of interferon-alpha production (GO:0032727)3.37985905
61response to type I interferon (GO:0034340)3.37906547
62type I interferon signaling pathway (GO:0060337)3.37819420
63cellular response to type I interferon (GO:0071357)3.37819420
64JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.36608539
65regulation of tolerance induction (GO:0002643)3.35972418
66granulocyte activation (GO:0036230)3.34045591
67regulation of regulatory T cell differentiation (GO:0045589)3.33002816
68regulation of T cell mediated cytotoxicity (GO:0001914)3.31806503
69positive regulation of B cell differentiation (GO:0045579)3.31729042
70positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.30825647
71regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.29043730
72positive regulation of alpha-beta T cell proliferation (GO:0046641)3.28279312
73tolerance induction (GO:0002507)3.27472823
74regulation of interferon-alpha production (GO:0032647)3.25985323
75positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.25471338
76positive regulation of T cell mediated cytotoxicity (GO:0001916)3.24484835
77positive regulation of interleukin-2 production (GO:0032743)3.23720502
78regulation of vitamin D biosynthetic process (GO:0060556)3.22856775
79dendritic cell differentiation (GO:0097028)3.20584917
80regulation of T-helper cell differentiation (GO:0045622)3.18595328
81positive regulation of natural killer cell differentiation (GO:0032825)3.16485899
82positive regulation of type 2 immune response (GO:0002830)3.16151168
83regulation of antigen processing and presentation (GO:0002577)3.13516748
84* regulation of RIG-I signaling pathway (GO:0039535)3.13209865
85T cell costimulation (GO:0031295)3.13027558
86lymphocyte costimulation (GO:0031294)3.11516686
87T cell migration (GO:0072678)3.11245830
88regulation of interferon-beta biosynthetic process (GO:0045357)3.10371030
89regulation of hypersensitivity (GO:0002883)3.10161763
90T cell mediated immunity (GO:0002456)3.10161232
91interferon-gamma production (GO:0032609)3.09437195
92regulation of isotype switching to IgG isotypes (GO:0048302)3.08964809
93regulation of interleukin-10 production (GO:0032653)3.08772010
94positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.08516321
95regulation of B cell differentiation (GO:0045577)3.07915653
96positive regulation of NF-kappaB import into nucleus (GO:0042346)3.07338473
97germinal center formation (GO:0002467)3.06982024
98defense response to protozoan (GO:0042832)3.06953344
99T cell proliferation (GO:0042098)3.04904823
100regulation of response to interferon-gamma (GO:0060330)3.04891566
101positive regulation of lymphocyte mediated immunity (GO:0002708)3.04621057
102positive regulation of T cell chemotaxis (GO:0010820)3.01997018
103regulation of T cell chemotaxis (GO:0010819)3.01997018
104regulation of interleukin-12 production (GO:0032655)3.01627046
105production of molecular mediator of immune response (GO:0002440)3.01273450
106thymic T cell selection (GO:0045061)3.00668855
107regulation of immunoglobulin secretion (GO:0051023)2.99702044
108macrophage activation involved in immune response (GO:0002281)2.99152474
109B cell mediated immunity (GO:0019724)2.98604960
110T cell lineage commitment (GO:0002360)2.98472291
111positive regulation of immunoglobulin production (GO:0002639)2.97765140
112mature B cell differentiation (GO:0002335)2.97551222
113positive T cell selection (GO:0043368)2.97426135
114B cell receptor signaling pathway (GO:0050853)2.97391392
115positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.95723125
116positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.94881148
117regulation of type I interferon-mediated signaling pathway (GO:0060338)2.94281045
118positive regulation of interleukin-17 production (GO:0032740)2.94151777
119positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.91159008
120regulation of T-helper 1 cell differentiation (GO:0045625)2.89812304
121regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.84656260
122T cell selection (GO:0045058)2.84567018
123positive regulation of defense response to virus by host (GO:0002230)2.84440987
124leukocyte aggregation (GO:0070486)2.83776511
125response to protozoan (GO:0001562)2.82821429
126positive regulation of interferon-beta production (GO:0032728)2.82589494
127regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.80593581
128CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.80427180
129T-helper cell differentiation (GO:0042093)2.80427180
130cellular response to zinc ion (GO:0071294)2.78048246
131positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.77330011
132lipopolysaccharide-mediated signaling pathway (GO:0031663)2.75725074
133regulation of activation of Janus kinase activity (GO:0010533)2.73733932
134respiratory burst (GO:0045730)2.73659405
135regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.73630667
136cytokine secretion (GO:0050663)2.70792603
137hepatocyte apoptotic process (GO:0097284)2.70549717
138response to interleukin-15 (GO:0070672)2.69602699
139B cell homeostasis (GO:0001782)2.68007543
140positive regulation of cytokine biosynthetic process (GO:0042108)2.67577680
141regulation of interleukin-2 biosynthetic process (GO:0045076)2.67503772
142myeloid cell activation involved in immune response (GO:0002275)2.67422496
143regulation of T cell tolerance induction (GO:0002664)2.67420846
144T-helper 1 type immune response (GO:0042088)2.66468282
145leukocyte mediated cytotoxicity (GO:0001909)2.66226095
146response to host defenses (GO:0052200)2.65231390
147response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.65231390
148response to host (GO:0075136)2.65231390
149response to host immune response (GO:0052572)2.64841190

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.02956826
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.55602260
3IRF8_21731497_ChIP-ChIP_J774_Mouse5.18444584
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.68511808
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.32693860
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.11624853
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.80487112
8IRF8_27001747_Chip-Seq_BMDM_Mouse3.52692053
9EGR1_19374776_ChIP-ChIP_THP-1_Human3.47602688
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.24998714
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.17845219
12STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.16969837
13* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.08746997
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.94532379
15SMAD_19615063_ChIP-ChIP_OVARY_Human2.78432556
16* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.75514537
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.74649309
18* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.74542279
19MYB_21317192_ChIP-Seq_ERMYB_Mouse2.67559959
20* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.63752550
21* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.58358602
22RUNX_20019798_ChIP-Seq_JUKART_Human2.52813547
23MYB_26560356_Chip-Seq_TH2_Human2.40309082
24Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.35776423
25MYB_26560356_Chip-Seq_TH1_Human2.05495304
26* MAF_26560356_Chip-Seq_TH1_Human1.90439087
27* SPI1_23547873_ChIP-Seq_NB4_Human1.90328880
28* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.77176526
29ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.76621911
30MYC_22102868_ChIP-Seq_BL_Human1.75758474
31SCL_19346495_ChIP-Seq_HPC-7_Human1.74988388
32* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.67793320
33E2F7_22180533_ChIP-Seq_HELA_Human1.62936192
34VDR_24763502_ChIP-Seq_THP-1_Human1.62439234
35RUNX1_22412390_ChIP-Seq_EML_Mouse1.60017979
36* NOTCH1_21737748_ChIP-Seq_TLL_Human1.59847687
37NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.59472177
38VDR_24787735_ChIP-Seq_THP-1_Human1.55748832
39TCF7_22412390_ChIP-Seq_EML_Mouse1.52911822
40PU_27001747_Chip-Seq_BMDM_Mouse1.52855951
41PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.52442151
42* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.52384164
43VDR_21846776_ChIP-Seq_THP-1_Human1.51737116
44* GATA3_27048872_Chip-Seq_THYMUS_Human1.50327954
45E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.49616451
46SPI1_23127762_ChIP-Seq_K562_Human1.45538999
47CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.44724957
48* UTX_26944678_Chip-Seq_JUKART_Human1.42850938
49GATA1_22025678_ChIP-Seq_K562_Human1.42583714
50VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.41620868
51MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.39482683
52ELF1_17652178_ChIP-ChIP_JURKAT_Human1.37096298
53PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.36922858
54RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.36479442
55GATA2_22383799_ChIP-Seq_G1ME_Mouse1.29173263
56GATA3_26560356_Chip-Seq_TH2_Human1.25197502
57CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22142266
58* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15184012
59KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.14697483
60NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.08775900
61LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.08279396
62FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.07820102
63GATA2_21666600_ChIP-Seq_HMVEC_Human1.07232137
64MAF_26560356_Chip-Seq_TH2_Human1.05818813
65FOXO3_23340844_ChIP-Seq_DLD1_Human1.04749754
66CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04350028
67SMRT_27268052_Chip-Seq_Bcells_Human1.02341777
68GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.01596011
69* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.01346413
70EGR1_19032775_ChIP-ChIP_M12_Human1.01020419
71SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.97835214
72* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97720856
73* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.93179161
74* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93001660
75BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.92769840
76LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.90481545
77TP63_17297297_ChIP-ChIP_HaCaT_Human0.88239671
78* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87890342
79SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.87525922
80CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.85832745
81* GATA1_19941827_ChIP-Seq_MEL_Mouse0.85535972
82FOXM1_23109430_ChIP-Seq_U2OS_Human0.85141682
83KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.83594420
84* RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.80599463
85KDM2B_26808549_Chip-Seq_SUP-B15_Human0.79464410
86CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.79204007
87* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.76533236
88VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.75398902
89FLI1_27457419_Chip-Seq_LIVER_Mouse0.75219166
90TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.75024021
91PU.1_20513432_ChIP-Seq_Bcells_Mouse0.74858390
92GATA2_19941826_ChIP-Seq_K562_Human0.74081185
93ELK3_25401928_ChIP-Seq_HUVEC_Human0.73481353
94HOXB4_20404135_ChIP-ChIP_EML_Mouse0.73130052
95CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.73016856
96* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.72432995
97* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.72432995
98PCGF2_27294783_Chip-Seq_NPCs_Mouse0.71700860
99KDM2B_26808549_Chip-Seq_DND41_Human0.70631090
100* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.69980998
101SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.69025229
102GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.68649129
103TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.67529827
104KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.67357882
105GATA1_19941826_ChIP-Seq_K562_Human0.67090595
106GATA3_26560356_Chip-Seq_TH1_Human0.66987203
107JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.66756811
108PPARA_22158963_ChIP-Seq_LIVER_Mouse0.66374586
109STAT1_20625510_ChIP-Seq_HELA_Human0.65971235
110PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.65560674
111CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.65177729
112JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.65110176
113BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.64781914
114TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.64748390
115* KAP1_22055183_ChIP-Seq_ESCs_Mouse0.63463193
116EGR1_23403033_ChIP-Seq_LIVER_Mouse0.62986734
117FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.62818984
118GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.62304709

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.60917233
2MP0000685_abnormal_immune_system3.75500056
3MP0005387_immune_system_phenotype3.29722435
4MP0001790_abnormal_immune_system3.29722435
5MP0009785_altered_susceptibility_to3.12071448
6MP0001800_abnormal_humoral_immune3.10459445
7MP0002138_abnormal_hepatobiliary_system3.07250961
8MP0005671_abnormal_response_to3.03199611
9MP0004510_myositis2.99938291
10MP0005000_abnormal_immune_tolerance2.93736255
11MP0003436_decreased_susceptibility_to2.87216670
12MP0002254_reproductive_system_inflammat2.78306861
13* MP0002452_abnormal_antigen_presenting2.73069348
14MP0002148_abnormal_hypersensitivity_rea2.70536540
15* MP0002723_abnormal_immune_serum2.58596089
16MP0005025_abnormal_response_to2.48306563
17* MP0002419_abnormal_innate_immunity2.45815664
18MP0003763_abnormal_thymus_physiology2.44080507
19MP0003303_peritoneal_inflammation2.44030584
20* MP0001819_abnormal_immune_cell2.37331283
21* MP0002420_abnormal_adaptive_immunity2.36837879
22MP0005310_abnormal_salivary_gland2.29071078
23MP0006082_CNS_inflammation2.22209546
24MP0003724_increased_susceptibility_to2.14453469
25MP0002166_altered_tumor_susceptibility2.12757817
26MP0002006_tumorigenesis2.10274821
27MP0001873_stomach_inflammation2.09318207
28MP0002405_respiratory_system_inflammati2.04441622
29MP0002398_abnormal_bone_marrow2.02918438
30MP0010155_abnormal_intestine_physiology1.94873306
31MP0004947_skin_inflammation1.94188923
32* MP0000716_abnormal_immune_system1.93159141
33MP0001853_heart_inflammation1.90395163
34* MP0001845_abnormal_inflammatory_respons1.73621471
35MP0002396_abnormal_hematopoietic_system1.72203542
36MP0002139_abnormal_hepatobiliary_system1.71963193
37MP0000689_abnormal_spleen_morphology1.66185746
38MP0003300_gastrointestinal_ulcer1.65482593
39MP0009333_abnormal_splenocyte_physiolog1.64225395
40MP0000569_abnormal_digit_pigmentation1.62058085
41MP0005464_abnormal_platelet_physiology1.59708032
42MP0002877_abnormal_melanocyte_morpholog1.55983600
43* MP0002429_abnormal_blood_cell1.55685238
44MP0002722_abnormal_immune_system1.53963735
45MP0001533_abnormal_skeleton_physiology1.48882615
46MP0009278_abnormal_bone_marrow1.38813267
47MP0009764_decreased_sensitivity_to1.37681957
48MP0003448_altered_tumor_morphology1.32159356
49MP0005379_endocrine/exocrine_gland_phen1.31731019
50MP0008469_abnormal_protein_level1.31188560
51MP0001545_abnormal_hematopoietic_system1.29473308
52MP0005397_hematopoietic_system_phenotyp1.29473308
53MP0005451_abnormal_body_composition1.24458679
54MP0005166_decreased_susceptibility_to1.24350536
55MP0000703_abnormal_thymus_morphology1.24269800
56MP0004808_abnormal_hematopoietic_stem1.21800310
57MP0001348_abnormal_lacrimal_gland1.19602547
58MP0003453_abnormal_keratinocyte_physiol1.16470595
59MP0001851_eye_inflammation1.13159608
60MP0002277_abnormal_respiratory_mucosa1.11810721
61MP0002009_preneoplasia1.11538799
62MP0002933_joint_inflammation1.09770459
63MP0000858_altered_metastatic_potential1.04603270
64MP0005076_abnormal_cell_differentiation1.04126060
65MP0004381_abnormal_hair_follicle1.01468974
66MP0002163_abnormal_gland_morphology0.99543163
67MP0000490_abnormal_crypts_of0.99397406
68MP0005174_abnormal_tail_pigmentation0.97328753
69MP0002876_abnormal_thyroid_physiology0.97325811
70MP0010352_gastrointestinal_tract_polyps0.95399824
71MP0002998_abnormal_bone_remodeling0.94520884
72MP0001346_abnormal_lacrimal_gland0.93971843
73MP0000343_altered_response_to0.93145594
74MP0003866_abnormal_defecation0.91506149
75MP0003091_abnormal_cell_migration0.90764837
76MP0002019_abnormal_tumor_incidence0.86057718
77MP0003183_abnormal_peptide_metabolism0.85574838
78MP0005058_abnormal_lysosome_morphology0.84874093
79MP0010307_abnormal_tumor_latency0.84057418
80MP0003191_abnormal_cellular_cholesterol0.83539813
81MP0009840_abnormal_foam_cell0.82035636
82MP0003075_altered_response_to0.80168184
83MP0009763_increased_sensitivity_to0.77736409
84MP0000465_gastrointestinal_hemorrhage0.77000827
85MP0008057_abnormal_DNA_replication0.76553899
86MP0005390_skeleton_phenotype0.74246663
87MP0004782_abnormal_surfactant_physiolog0.74026015
88MP0005360_urolithiasis0.68555287
89MP0000249_abnormal_blood_vessel0.67524229
90MP0003045_fibrosis0.67259491
91MP0002136_abnormal_kidney_physiology0.66669719
92MP0003252_abnormal_bile_duct0.65834723
93MP0000767_abnormal_smooth_muscle0.65665562
94MP0008961_abnormal_basal_metabolism0.65255959
95MP0002693_abnormal_pancreas_physiology0.63941153
96MP0005167_abnormal_blood-brain_barrier0.63561958
97MP0003195_calcinosis0.63230343
98MP0009765_abnormal_xenobiotic_induced0.63021945
99MP0000371_diluted_coat_color0.61952662
100MP0000604_amyloidosis0.61856249
101MP0002928_abnormal_bile_duct0.61094677
102MP0001663_abnormal_digestive_system0.59028076
103MP0005023_abnormal_wound_healing0.58408312
104MP0008260_abnormal_autophagy0.58378668
105MP0000609_abnormal_liver_physiology0.57134217
106MP0005584_abnormal_enzyme/coenzyme_acti0.56834235
107MP0008004_abnormal_stomach_pH0.56549525
108MP0003806_abnormal_nucleotide_metabolis0.56349554
109MP0001666_abnormal_nutrient_absorption0.56140742
110MP0001881_abnormal_mammary_gland0.55359815
111MP0003693_abnormal_embryo_hatching0.55211223
112MP0001216_abnormal_epidermal_layer0.54762422
113MP0003077_abnormal_cell_cycle0.54639719
114MP0005164_abnormal_response_to0.54491087
115MP0003566_abnormal_cell_adhesion0.54372040
116MP0005075_abnormal_melanosome_morpholog0.53119631
117MP0001119_abnormal_female_reproductive0.52988096
118MP0001915_intracranial_hemorrhage0.52976225
119MP0003172_abnormal_lysosome_physiology0.52551135
120MP0009115_abnormal_fat_cell0.51373644
121MP0009643_abnormal_urine_homeostasis0.49751020
122MP0003656_abnormal_erythrocyte_physiolo0.46915966
123MP0003795_abnormal_bone_structure0.46737327

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.63709336
2Recurrent abscess formation (HP:0002722)5.52111881
3Recurrent bacterial skin infections (HP:0005406)5.32421476
4Myositis (HP:0100614)4.84235831
5Optic neuritis (HP:0100653)4.71189742
6Retrobulbar optic neuritis (HP:0100654)4.71189742
7Recurrent fungal infections (HP:0002841)4.67683907
8Orchitis (HP:0100796)4.49978994
9Elevated erythrocyte sedimentation rate (HP:0003565)4.31225760
10Recurrent viral infections (HP:0004429)4.28638919
11Recurrent skin infections (HP:0001581)3.95469289
12Vasculitis (HP:0002633)3.93825293
13Chronic mucocutaneous candidiasis (HP:0002728)3.80366042
14Recurrent cutaneous fungal infections (HP:0011370)3.80366042
15Autoimmune thrombocytopenia (HP:0001973)3.80025692
16Recurrent gram-negative bacterial infections (HP:0005420)3.72935895
17Stomatitis (HP:0010280)3.70750052
18* Mediastinal lymphadenopathy (HP:0100721)3.67336024
19Agammaglobulinemia (HP:0004432)3.61707885
20Abnormal delayed hypersensitivity skin test (HP:0002963)3.50046061
21Chronic otitis media (HP:0000389)3.42438064
22IgM deficiency (HP:0002850)3.41649967
23Abnormality of macrophages (HP:0004311)3.36875344
24Abnormality of the fingertips (HP:0001211)3.35439284
25Cellulitis (HP:0100658)3.32911399
26Meningitis (HP:0001287)3.29405009
27Keratoconjunctivitis (HP:0001096)3.29340406
28Recurrent bronchitis (HP:0002837)3.27021371
29Gastrointestinal stroma tumor (HP:0100723)3.23742468
30* Pulmonary infiltrates (HP:0002113)3.15040735
31Increased IgM level (HP:0003496)3.14340691
32Gingivitis (HP:0000230)3.11701483
33Colitis (HP:0002583)3.10742480
34Gastrointestinal infarctions (HP:0005244)3.08857431
35Leukocytosis (HP:0001974)3.08020992
36Arterial thrombosis (HP:0004420)3.06356147
37Keratoconjunctivitis sicca (HP:0001097)3.04435405
38Eosinophilia (HP:0001880)3.03383759
39Pustule (HP:0200039)3.00276104
40IgA deficiency (HP:0002720)2.97447204
41Prostate neoplasm (HP:0100787)2.96682857
42Periodontitis (HP:0000704)2.95738555
43Abnormality of T cell number (HP:0011839)2.93078171
44Abnormality of eosinophils (HP:0001879)2.89118405
45Inflammation of the large intestine (HP:0002037)2.85642866
46Obstructive lung disease (HP:0006536)2.83536927
47Chronic obstructive pulmonary disease (HP:0006510)2.83536927
48Panhypogammaglobulinemia (HP:0003139)2.79782315
49Interstitial pulmonary disease (HP:0006530)2.77292150
50IgG deficiency (HP:0004315)2.76080027
51Increased IgE level (HP:0003212)2.72871481
52Granulocytopenia (HP:0001913)2.72687147
53Nasal polyposis (HP:0100582)2.71233150
54Osteomyelitis (HP:0002754)2.69006083
55Gangrene (HP:0100758)2.65330647
56Abnormality of T cells (HP:0002843)2.65159024
57Hematochezia (HP:0002573)2.62036711
58Abnormality of T cell physiology (HP:0011840)2.61954184
59Gastrointestinal inflammation (HP:0004386)2.61891204
60Hemoptysis (HP:0002105)2.59987969
61T lymphocytopenia (HP:0005403)2.59947744
62Abnormality of cells of the lymphoid lineage (HP:0012140)2.59597994
63Lymphopenia (HP:0001888)2.59061849
64Thrombocytosis (HP:0001894)2.58250331
65Emphysema (HP:0002097)2.53216302
66Chronic diarrhea (HP:0002028)2.52495424
67Recurrent pneumonia (HP:0006532)2.52377697
68Fatigue (HP:0012378)2.50822275
69Thyroiditis (HP:0100646)2.46432715
70Abnormality of the prostate (HP:0008775)2.46128964
71Abnormality of the nasal mucosa (HP:0000433)2.43009475
72Myocardial infarction (HP:0001658)2.42378982
73Encephalitis (HP:0002383)2.41728907
74Combined immunodeficiency (HP:0005387)2.38185784
75Hypergammaglobulinemia (HP:0010702)2.38080487
76Acute myeloid leukemia (HP:0004808)2.35114744
77Abnormality of the pleura (HP:0002103)2.32876234
78Alveolar cell carcinoma (HP:0006519)2.32139502
79Recurrent lower respiratory tract infections (HP:0002783)2.31137553
80Autoimmune hemolytic anemia (HP:0001890)2.30071066
81Gingival bleeding (HP:0000225)2.29450835
82Recurrent sinusitis (HP:0011108)2.26995700
83Severe combined immunodeficiency (HP:0004430)2.25031569
84Spontaneous hematomas (HP:0007420)2.23032372
85Vacuolated lymphocytes (HP:0001922)2.23003903
86Abnormality of glycolipid metabolism (HP:0010969)2.22340006
87Abnormality of liposaccharide metabolism (HP:0010968)2.22340006
88Abnormality of glycosphingolipid metabolism (HP:0004343)2.22340006
89Neoplasm of the tracheobronchial system (HP:0100552)2.21802783
90Malnutrition (HP:0004395)2.20402786
91Pulmonary embolism (HP:0002204)2.20286088
92Papilloma (HP:0012740)2.19235316
93Verrucae (HP:0200043)2.19235316
94Loss of speech (HP:0002371)2.18026580
95Urticaria (HP:0001025)2.17664404
96Basal ganglia calcification (HP:0002135)2.17642332
97Joint swelling (HP:0001386)2.17605323
98Hypochromic anemia (HP:0001931)2.16674150
99Bronchitis (HP:0012387)2.10165246
100Thick nail (HP:0001805)2.09553285
101Abnormality of B cell number (HP:0010975)2.07686744
102B lymphocytopenia (HP:0010976)2.07686744
103Skin ulcer (HP:0200042)2.06750787
104Restrictive lung disease (HP:0002091)2.03874843
105Keratitis (HP:0000491)2.03064854
106Chronic sinusitis (HP:0011109)2.00927400
107Viral hepatitis (HP:0006562)2.00317425
108Anorexia (HP:0002039)1.99416119
109Arthralgia (HP:0002829)1.99237769
110Leukopenia (HP:0001882)1.98060469
111Stomach cancer (HP:0012126)1.97885916
112Chest pain (HP:0100749)1.95686354
113Persistence of primary teeth (HP:0006335)1.94862015
114Lymphoma (HP:0002665)1.94056079
115Pulmonary fibrosis (HP:0002206)1.92935800
116Skin rash (HP:0000988)1.92880809
117Premature loss of primary teeth (HP:0006323)1.91331980
118Osteolytic defects of the hand bones (HP:0009699)1.91104679
119Amaurosis fugax (HP:0100576)1.89177125
120Polyneuropathy (HP:0001271)1.85935018
121Acute hepatic failure (HP:0006554)1.85121129

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K144.70536912
2MAP4K13.42151490
3MAP3K133.34943522
4TYK23.29563761
5TBK13.03908327
6JAK32.98157128
7TAOK32.71057278
8IKBKB2.65365667
9TXK2.64258992
10PRPF4B2.60296416
11IRAK42.58088546
12IKBKE2.57698935
13IRAK32.39480132
14JAK12.28005118
15STK32.22588273
16BMPR22.18592158
17CHUK2.17190001
18BCR2.14731838
19TAOK22.12798287
20KIT2.06641903
21STK101.98209794
22EPHA31.79969998
23STK241.70387078
24RIPK41.65633753
25BLK1.59499534
26MAP3K111.58050061
27MAP3K101.57433761
28NLK1.54376871
29FGFR41.53112368
30EPHB11.52392674
31ZAP701.47230479
32NEK91.44047801
33SYK1.28767766
34ERN11.28432569
35BTK1.27921001
36PIM11.26673842
37FGFR31.23620827
38CSF1R1.19172776
39MOS1.16636501
40TEC1.16310653
41CSK1.15685211
42RPS6KA41.13212837
43EEF2K1.09765098
44CAMKK21.07277197
45JAK21.05177777
46LCK1.03141990
47HCK1.03022169
48MATK1.01779448
49ITK1.01533373
50MAP2K60.99085308
51NUAK10.98986173
52IRAK10.95662391
53MELK0.93993065
54PLK40.89301861
55GRK60.88578713
56GRK70.87878583
57CDK90.84212872
58LYN0.83573076
59EIF2AK30.82285679
60MAP3K60.79957500
61RAF10.78761489
62PIM20.77733931
63PTK60.74904046
64LRRK20.72998782
65MAPK110.72512293
66MARK30.68692368
67PRKAA20.68463516
68FLT30.68259369
69TRPM70.66688084
70TGFBR20.66004730
71ADRBK20.64779294
72STK40.61012440
73CDK120.59350198
74PIK3CG0.59014331
75TAOK10.58561018
76CDC42BPA0.57079303
77MAP2K30.56438438
78PRKCQ0.54784006
79PDK10.53418403
80ABL10.53104229
81NME20.52600326
82ARAF0.52007439
83CDK40.50627990
84MST40.50393902
85MAPKAPK20.49025120
86ACVR1B0.48394334
87SIK20.46035352
88TTK0.45892841
89RIPK10.45682220
90TSSK60.44458210
91DMPK0.44424544
92MAP3K50.43593517
93PASK0.43195064
94EIF2AK20.42802202
95MAP3K80.41088042
96MAP3K10.39384708
97HIPK20.39186844
98RPS6KA50.38377448
99KSR20.38220657
100MAPKAPK30.37869814
101MAP3K90.37817186
102FER0.36260014
103MAP3K120.35454292
104ERBB40.34965613
105IRAK20.34927263
106CDK60.31882133
107FGR0.31074836
108LATS10.30716543
109CAMKK10.30570599
110BMPR1B0.30175539
111FES0.29808325
112KSR10.28438886
113TGFBR10.27903330
114FRK0.27095241
115SIK30.26879329
116EGFR0.26662334
117MAPK70.26321767
118PRKCD0.25724010
119SMG10.25666877
120CLK10.25648308
121IGF1R0.24500905
122MAPKAPK50.24268209
123CDK80.23941633
124RPS6KA10.23834771
125NEK20.23824335
126MST1R0.23738004
127TLK10.22765158
128MAP3K30.22369333
129INSR0.21487045
130ALK0.20546708
131MAPK40.17424982

Predicted pathways (KEGG)

RankGene SetZ-score
1* NF-kappa B signaling pathway_Homo sapiens_hsa040643.25082178
2Leishmaniasis_Homo sapiens_hsa051402.96253130
3Intestinal immune network for IgA production_Homo sapiens_hsa046722.73464111
4Allograft rejection_Homo sapiens_hsa053302.71297228
5Primary immunodeficiency_Homo sapiens_hsa053402.66175638
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.62074298
7Graft-versus-host disease_Homo sapiens_hsa053322.53117195
8Osteoclast differentiation_Homo sapiens_hsa043802.46004950
9Measles_Homo sapiens_hsa051622.41459981
10Toll-like receptor signaling pathway_Homo sapiens_hsa046202.29525823
11* NOD-like receptor signaling pathway_Homo sapiens_hsa046212.27401717
12RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.24677363
13B cell receptor signaling pathway_Homo sapiens_hsa046622.20826897
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.09786398
15* TNF signaling pathway_Homo sapiens_hsa046682.08328933
16Herpes simplex infection_Homo sapiens_hsa051681.87623139
17Jak-STAT signaling pathway_Homo sapiens_hsa046301.86610797
18Legionellosis_Homo sapiens_hsa051341.82521545
19Antigen processing and presentation_Homo sapiens_hsa046121.81345164
20Influenza A_Homo sapiens_hsa051641.80816810
21* Toxoplasmosis_Homo sapiens_hsa051451.79694378
22Hematopoietic cell lineage_Homo sapiens_hsa046401.78685072
23Malaria_Homo sapiens_hsa051441.71338164
24T cell receptor signaling pathway_Homo sapiens_hsa046601.61477785
25Staphylococcus aureus infection_Homo sapiens_hsa051501.59166331
26Tuberculosis_Homo sapiens_hsa051521.57182771
27Autoimmune thyroid disease_Homo sapiens_hsa053201.53664172
28* Apoptosis_Homo sapiens_hsa042101.49764600
29Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.48451158
30Pertussis_Homo sapiens_hsa051331.47011585
31Asthma_Homo sapiens_hsa053101.45384801
32Chemokine signaling pathway_Homo sapiens_hsa040621.45105217
33Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.42896391
34Hepatitis B_Homo sapiens_hsa051611.39228237
35Type I diabetes mellitus_Homo sapiens_hsa049401.37820922
36Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.34303355
37Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.29878072
38African trypanosomiasis_Homo sapiens_hsa051431.28734826
39Pancreatic cancer_Homo sapiens_hsa052121.27011164
40Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.23681323
41Rheumatoid arthritis_Homo sapiens_hsa053231.19133154
42Shigellosis_Homo sapiens_hsa051311.18747639
43Acute myeloid leukemia_Homo sapiens_hsa052211.16487178
44Prolactin signaling pathway_Homo sapiens_hsa049171.13472604
45Hepatitis C_Homo sapiens_hsa051601.12492865
46Viral myocarditis_Homo sapiens_hsa054161.08490656
47Chronic myeloid leukemia_Homo sapiens_hsa052201.08017432
48Epstein-Barr virus infection_Homo sapiens_hsa051691.04275525
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.03786703
50p53 signaling pathway_Homo sapiens_hsa041150.93677823
51* Small cell lung cancer_Homo sapiens_hsa052220.93513075
52Salmonella infection_Homo sapiens_hsa051320.93111863
53* Transcriptional misregulation in cancer_Homo sapiens_hsa052020.88167329
54Leukocyte transendothelial migration_Homo sapiens_hsa046700.85951397
55Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.84716643
56Viral carcinogenesis_Homo sapiens_hsa052030.82346196
57HTLV-I infection_Homo sapiens_hsa051660.75177137
58Other glycan degradation_Homo sapiens_hsa005110.69623339
59MicroRNAs in cancer_Homo sapiens_hsa052060.65506542
60Neurotrophin signaling pathway_Homo sapiens_hsa047220.64463930
61FoxO signaling pathway_Homo sapiens_hsa040680.64282800
62Platelet activation_Homo sapiens_hsa046110.60571953
63Amoebiasis_Homo sapiens_hsa051460.57265077
64Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.55952721
65Colorectal cancer_Homo sapiens_hsa052100.54713289
66Adipocytokine signaling pathway_Homo sapiens_hsa049200.53167171
67Cyanoamino acid metabolism_Homo sapiens_hsa004600.51872692
68Non-homologous end-joining_Homo sapiens_hsa034500.51524091
69MAPK signaling pathway_Homo sapiens_hsa040100.51419130
70Cell cycle_Homo sapiens_hsa041100.49918277
71Dorso-ventral axis formation_Homo sapiens_hsa043200.47428543
72VEGF signaling pathway_Homo sapiens_hsa043700.46950756
73Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45617716
74Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.44347483
75Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43575122
76Ovarian steroidogenesis_Homo sapiens_hsa049130.42796582
77Lysosome_Homo sapiens_hsa041420.41717302
78Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.41707906
79Notch signaling pathway_Homo sapiens_hsa043300.41573994
80Phagosome_Homo sapiens_hsa041450.41517128
81Prostate cancer_Homo sapiens_hsa052150.40337764
82Insulin resistance_Homo sapiens_hsa049310.38842673
83Base excision repair_Homo sapiens_hsa034100.38836824
84Homologous recombination_Homo sapiens_hsa034400.38485181
85Caffeine metabolism_Homo sapiens_hsa002320.36912996
86alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.35931110
87RNA degradation_Homo sapiens_hsa030180.35819489
88Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.34924351
89Glycosaminoglycan degradation_Homo sapiens_hsa005310.33286657
90Sphingolipid signaling pathway_Homo sapiens_hsa040710.33285013
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33026833
92SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32821897
93Non-small cell lung cancer_Homo sapiens_hsa052230.30448791
94Carbohydrate digestion and absorption_Homo sapiens_hsa049730.29997829
95HIF-1 signaling pathway_Homo sapiens_hsa040660.29478084
96Circadian rhythm_Homo sapiens_hsa047100.28565079
97* Pathways in cancer_Homo sapiens_hsa052000.28326606
98Regulation of actin cytoskeleton_Homo sapiens_hsa048100.27773073
99TGF-beta signaling pathway_Homo sapiens_hsa043500.27109124
100Choline metabolism in cancer_Homo sapiens_hsa052310.26509450
101Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.26140719
102Endocytosis_Homo sapiens_hsa041440.25445907
103Linoleic acid metabolism_Homo sapiens_hsa005910.25299663
104Inositol phosphate metabolism_Homo sapiens_hsa005620.23865270
105Drug metabolism - other enzymes_Homo sapiens_hsa009830.23479129
106Renin-angiotensin system_Homo sapiens_hsa046140.22066391
107Adherens junction_Homo sapiens_hsa045200.20659353
108Proteoglycans in cancer_Homo sapiens_hsa052050.20292261
109ABC transporters_Homo sapiens_hsa020100.20271332
110Renal cell carcinoma_Homo sapiens_hsa052110.20152396
111Sulfur metabolism_Homo sapiens_hsa009200.18235391
112Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.17651002
113Mineral absorption_Homo sapiens_hsa049780.15355950
114Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.14268988
115Glycerolipid metabolism_Homo sapiens_hsa005610.13062139
116Thyroid cancer_Homo sapiens_hsa052160.12754211
117Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.11231959
118Fat digestion and absorption_Homo sapiens_hsa049750.07962526
119Type II diabetes mellitus_Homo sapiens_hsa049300.07319831
120Arachidonic acid metabolism_Homo sapiens_hsa005900.05711916
121Sphingolipid metabolism_Homo sapiens_hsa006000.05383775
122Vitamin digestion and absorption_Homo sapiens_hsa049770.04936323
123Systemic lupus erythematosus_Homo sapiens_hsa053220.04796036

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