BIRC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* NIK/NF-kappaB signaling (GO:0038061)7.15400710
2antigen processing and presentation of endogenous antigen (GO:0019883)5.82468784
3regulation of dendritic cell antigen processing and presentation (GO:0002604)5.78596534
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.84628917
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.84628917
6melanin biosynthetic process (GO:0042438)4.66852854
7myeloid dendritic cell differentiation (GO:0043011)4.61546880
8CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)4.54891354
9T-helper cell differentiation (GO:0042093)4.54891354
10positive regulation of antigen processing and presentation (GO:0002579)4.48556993
11myeloid dendritic cell activation (GO:0001773)4.47630001
12negative thymic T cell selection (GO:0045060)4.40902461
13positive regulation of gamma-delta T cell activation (GO:0046645)4.40116848
14melanin metabolic process (GO:0006582)4.36952823
15positive regulation of natural killer cell differentiation (GO:0032825)4.30339150
16antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.29877408
17negative T cell selection (GO:0043383)4.29809063
18regulation of interleukin-12 biosynthetic process (GO:0045075)4.25050484
19hepatocyte apoptotic process (GO:0097284)4.23149083
20growth hormone receptor signaling pathway (GO:0060396)4.21007664
21positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.17944330
22regulation of T cell tolerance induction (GO:0002664)3.97070495
23T cell differentiation involved in immune response (GO:0002292)3.91795240
24alpha-beta T cell differentiation involved in immune response (GO:0002293)3.91795240
25alpha-beta T cell activation involved in immune response (GO:0002287)3.91795240
26regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.91626866
27dendritic cell differentiation (GO:0097028)3.89587663
28response to muramyl dipeptide (GO:0032495)3.89344333
29neutrophil activation involved in immune response (GO:0002283)3.85298566
30secondary metabolite biosynthetic process (GO:0044550)3.82645826
31positive regulation of interleukin-2 production (GO:0032743)3.78526247
32regulation of antigen processing and presentation (GO:0002577)3.76332789
33regulation of T-helper 1 cell differentiation (GO:0045625)3.75954199
34adhesion of symbiont to host cell (GO:0044650)3.72261460
35virion attachment to host cell (GO:0019062)3.72261460
36cellular response to growth hormone stimulus (GO:0071378)3.70824158
37neutrophil activation (GO:0042119)3.68387032
38positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.64728931
39granulocyte activation (GO:0036230)3.54833927
40positive regulation of T cell cytokine production (GO:0002726)3.51140214
41CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.49777357
42positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.46025039
43positive regulation of interleukin-12 production (GO:0032735)3.44254591
44positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.43260728
45cell adhesion mediated by integrin (GO:0033627)3.43057932
46protein K11-linked deubiquitination (GO:0035871)3.41821100
47positive regulation of B cell differentiation (GO:0045579)3.40539640
48regulation of tolerance induction (GO:0002643)3.40320057
49cilium or flagellum-dependent cell motility (GO:0001539)3.39246344
50axonemal dynein complex assembly (GO:0070286)3.38792620
51myelin assembly (GO:0032288)3.35749766
52positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.30184523
53* regulation of RIG-I signaling pathway (GO:0039535)3.28897456
54regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.22743784
55CD4-positive, alpha-beta T cell activation (GO:0035710)3.21559389
56natural killer cell mediated cytotoxicity (GO:0042267)3.21559268
57natural killer cell mediated immunity (GO:0002228)3.21559268
58T cell migration (GO:0072678)3.21305463
59positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.20976285
60positive regulation of humoral immune response (GO:0002922)3.20785634
61regulation of alpha-beta T cell proliferation (GO:0046640)3.19513950
62positive regulation of T-helper cell differentiation (GO:0045624)3.17998000
63response to prostaglandin E (GO:0034695)3.14918176
64cellular response to type I interferon (GO:0071357)3.14468666
65type I interferon signaling pathway (GO:0060337)3.14468666
66negative regulation of interleukin-1 beta production (GO:0032691)3.13770583
67T-helper 1 type immune response (GO:0042088)3.13293476
68regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.12602648
69response to type I interferon (GO:0034340)3.12504646
70regulation of B cell differentiation (GO:0045577)3.10410924
71neural tube formation (GO:0001841)3.09503766
72regulation of gamma-delta T cell differentiation (GO:0045586)3.08934459
73JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.08160585
74positive regulation of mitotic sister chromatid separation (GO:1901970)3.06238517
75positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.06238517
76positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.06238517
77regulation of natural killer cell differentiation (GO:0032823)3.03925113
78T cell activation involved in immune response (GO:0002286)3.03810873
79regulation of gamma-delta T cell activation (GO:0046643)3.02811553
80regulation of cytokine secretion involved in immune response (GO:0002739)3.01220862
81positive regulation of interleukin-17 production (GO:0032740)3.00730796
82regulation of T-helper cell differentiation (GO:0045622)2.97942261
83interferon-gamma-mediated signaling pathway (GO:0060333)2.96736970
84histone H3-K36 demethylation (GO:0070544)2.94525639
85negative regulation of neurotransmitter secretion (GO:0046929)2.92742871
86cellular response to interleukin-15 (GO:0071350)2.92719092
87positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.92677184
88detection of molecule of bacterial origin (GO:0032490)2.90899057
89negative regulation of interleukin-1 production (GO:0032692)2.90009476
90positive regulation of protein autophosphorylation (GO:0031954)2.88779579
91positive regulation of type 2 immune response (GO:0002830)2.86876721
92ruffle organization (GO:0031529)2.83600145
93response to interleukin-15 (GO:0070672)2.82628001
94alpha-beta T cell activation (GO:0046631)2.82247384
95positive regulation of natural killer cell activation (GO:0032816)2.82242568
96* regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.81945127
97regulation of hypersensitivity (GO:0002883)2.81254991
98negative regulation of NF-kappaB import into nucleus (GO:0042347)2.78944207
99T cell selection (GO:0045058)2.78915156
100regulation of immunoglobulin secretion (GO:0051023)2.78539925
101dendritic cell chemotaxis (GO:0002407)2.77905036
102negative regulation of T-helper cell differentiation (GO:0045623)2.77418100
103negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.77418100
104negative regulation of B cell activation (GO:0050869)2.76781996
105adhesion of symbiont to host (GO:0044406)2.76392685
106regulation of interleukin-2 biosynthetic process (GO:0045076)2.73933722
107COPII vesicle coating (GO:0048208)2.73757755
108positive regulation of tolerance induction (GO:0002645)2.72770229
109T cell proliferation (GO:0042098)2.72562088
110regulation of MHC class I biosynthetic process (GO:0045343)2.72432788
111positive regulation of cell size (GO:0045793)2.71361218
112Rap protein signal transduction (GO:0032486)2.71136354
113regulation of T cell receptor signaling pathway (GO:0050856)2.70264843
114lymphocyte migration (GO:0072676)2.70075963
115regulation of vitamin D biosynthetic process (GO:0060556)2.68358643
116regulation of interleukin-2 production (GO:0032663)2.68228753
117regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.67475560
118dendritic cell migration (GO:0036336)2.67391100
119regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.64060676
120protein targeting to vacuole (GO:0006623)2.63960100
121protein targeting to lysosome (GO:0006622)2.63960100
122establishment of protein localization to vacuole (GO:0072666)2.63960100
123negative regulation of innate immune response (GO:0045824)2.63339332
124thymic T cell selection (GO:0045061)2.63268161
125* necroptotic process (GO:0070266)2.63259320
126G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.62439707
127mature B cell differentiation (GO:0002335)2.60959059
128positive regulation of alpha-beta T cell proliferation (GO:0046641)2.60710106
129positive regulation of receptor recycling (GO:0001921)2.58933934
130positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.57813801
131protein localization to endosome (GO:0036010)2.56966035
132proteasome assembly (GO:0043248)2.56191780
133neutrophil mediated immunity (GO:0002446)2.55644279
134microglial cell activation (GO:0001774)2.55066708
135negative regulation of anoikis (GO:2000811)2.49047195
136regulation of integrin-mediated signaling pathway (GO:2001044)2.47298094
137negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.46420541
138response to hyperoxia (GO:0055093)2.45927530
139response to increased oxygen levels (GO:0036296)2.45927530
140regulation of transforming growth factor beta2 production (GO:0032909)2.44192073
141regulation of interferon-beta biosynthetic process (GO:0045357)2.44042809
142negative regulation of protein localization to plasma membrane (GO:1903077)2.43974251
143inositol phosphate dephosphorylation (GO:0046855)2.43075556
144phosphorylated carbohydrate dephosphorylation (GO:0046838)2.43075556
145positive regulation of macrophage differentiation (GO:0045651)2.43059098
146regulation of metalloenzyme activity (GO:0048552)2.42916324
147interleukin-6-mediated signaling pathway (GO:0070102)2.40980831
148negative regulation of interleukin-12 production (GO:0032695)2.38123743
149negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.36366981
150positive regulation of T cell chemotaxis (GO:0010820)2.35319190
151regulation of T cell chemotaxis (GO:0010819)2.35319190
152regulation of fibroblast apoptotic process (GO:2000269)2.34758000
153monoubiquitinated protein deubiquitination (GO:0035520)2.33856612
154regulation of chronic inflammatory response (GO:0002676)2.33553303
155cellular response to ethanol (GO:0071361)2.32000487
156regulation of protein autophosphorylation (GO:0031952)2.30997524
157melanosome organization (GO:0032438)2.30409942
158phosphatidylinositol dephosphorylation (GO:0046856)2.29324517
159negative regulation of lipid storage (GO:0010888)2.29036582
160negative regulation of interleukin-17 production (GO:0032700)2.28645105
161preassembly of GPI anchor in ER membrane (GO:0016254)2.28415323
162mannosylation (GO:0097502)2.28340776
163negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.25912171
164pigment granule organization (GO:0048753)2.24848239
165pore complex assembly (GO:0046931)2.23394373
166synapsis (GO:0007129)2.22925847
167histone mRNA catabolic process (GO:0071044)2.21885040
168myeloid leukocyte mediated immunity (GO:0002444)2.20989633
169keratinocyte development (GO:0003334)2.20591221
170regulation of interferon-alpha production (GO:0032647)2.19918725
171regulation of interleukin-8 biosynthetic process (GO:0045414)2.19603688
172regulation of interleukin-1 beta production (GO:0032651)2.17054908
173regulation of interleukin-1 production (GO:0032652)2.16982983
174phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.16358721
175inositol phosphate catabolic process (GO:0071545)2.16030782
176parental behavior (GO:0060746)2.15686298
177developmental pigmentation (GO:0048066)2.15647852
178* regulation of necroptotic process (GO:0060544)2.15556934
179regulation of vitamin metabolic process (GO:0030656)2.15391052
180glial cell proliferation (GO:0014009)2.15346601
181fibril organization (GO:0097435)2.14924801
182natural killer cell activation involved in immune response (GO:0002323)2.14701850
183negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.14376089
184piRNA metabolic process (GO:0034587)2.14272171
185positive regulation of interleukin-1 beta secretion (GO:0050718)2.13444591
186positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.13117558
187membrane raft organization (GO:0031579)2.12388782
188regulation of NF-kappaB import into nucleus (GO:0042345)2.11921611
189response to copper ion (GO:0046688)2.09263525
190regulation of T-helper 2 cell differentiation (GO:0045628)2.09095581
191cellular response to interferon-alpha (GO:0035457)2.09036112
192negative regulation of protein autophosphorylation (GO:0031953)2.08560934
193* necrotic cell death (GO:0070265)2.08514377
194osteoclast differentiation (GO:0030316)2.08041494
195* programmed necrotic cell death (GO:0097300)2.07366705
196negative regulation of fibroblast apoptotic process (GO:2000270)2.07351584

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.54541498
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.97808285
3* IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.62017182
4IRF8_21731497_ChIP-ChIP_J774_Mouse4.00203021
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.41004755
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.21157870
7STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.17118952
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.07573375
9SMAD_19615063_ChIP-ChIP_OVARY_Human2.84556354
10IRF8_27001747_Chip-Seq_BMDM_Mouse2.69753619
11VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.56609682
12GATA1_22025678_ChIP-Seq_K562_Human2.55769977
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.53603045
14RUNX_20019798_ChIP-Seq_JUKART_Human2.43783954
15BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.35569526
16STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.33210430
17STAT4_19710469_ChIP-ChIP_TH1__Mouse2.18622246
18* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.15016598
19MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.14695012
20SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.12839712
21ELK1_19687146_ChIP-ChIP_HELA_Human2.04292724
22TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.99962898
23CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.97303222
24EGR1_19374776_ChIP-ChIP_THP-1_Human1.94017758
25CDX2_19796622_ChIP-Seq_MESCs_Mouse1.91085968
26* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.88897236
27CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.88199353
28BRD4_25478319_ChIP-Seq_HGPS_Human1.84793789
29SCL_19346495_ChIP-Seq_HPC-7_Human1.80195583
30NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.78565165
31MYB_26560356_Chip-Seq_TH2_Human1.75423864
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.72498000
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.67469434
34NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.66241008
35NRF2_20460467_ChIP-Seq_MEFs_Mouse1.66241008
36TAF15_26573619_Chip-Seq_HEK293_Human1.65102083
37EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.65098968
38CJUN_26792858_Chip-Seq_BT549_Human1.62164203
39VDR_24787735_ChIP-Seq_THP-1_Human1.61262752
40SALL4_18804426_ChIP-ChIP_XEN_Mouse1.59922247
41* GATA3_27048872_Chip-Seq_THYMUS_Human1.57017483
42SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.56983342
43ELF1_17652178_ChIP-ChIP_JURKAT_Human1.53764259
44Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.52037328
45IGF1R_20145208_ChIP-Seq_DFB_Human1.51581021
46GBX2_23144817_ChIP-Seq_PC3_Human1.50854881
47* MYB_26560356_Chip-Seq_TH1_Human1.50658636
48FUS_26573619_Chip-Seq_HEK293_Human1.49528168
49ER_23166858_ChIP-Seq_MCF-7_Human1.49272233
50GATA3_26560356_Chip-Seq_TH2_Human1.45904058
51* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.43934599
52PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.43313066
53MYB_21317192_ChIP-Seq_ERMYB_Mouse1.41253224
54PCGF2_27294783_Chip-Seq_ESCs_Mouse1.41247487
55SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.40785300
56SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.40785300
57FOXM1_26456572_ChIP-Seq_MCF-7_Human1.38972944
58POU3F2_20337985_ChIP-ChIP_501MEL_Human1.38802161
59FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.35369155
60ZFP57_27257070_Chip-Seq_ESCs_Mouse1.34827920
61CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.30291246
62STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.28023731
63SMRT_27268052_Chip-Seq_Bcells_Human1.27781389
64WT1_19549856_ChIP-ChIP_CCG9911_Human1.27095027
65PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26154504
66LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.25893943
67NANOG_18555785_Chip-Seq_ESCs_Mouse1.22724902
68* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21287117
69CRX_20693478_ChIP-Seq_RETINA_Mouse1.20639143
70TP53_16413492_ChIP-PET_HCT116_Human1.20017768
71PCGF2_27294783_Chip-Seq_NPCs_Mouse1.19424627
72* MAF_26560356_Chip-Seq_TH1_Human1.19092964
73OCT4_21477851_ChIP-Seq_ESCs_Mouse1.18476520
74GATA2_21666600_ChIP-Seq_HMVEC_Human1.17974945
75UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17203622
76ZNF217_24962896_ChIP-Seq_MCF-7_Human1.16272582
77TP63_23658742_ChIP-Seq_EP156T_Human1.12966572
78* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.11158593
79KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.10993285
80FOXO3_23340844_ChIP-Seq_DLD1_Human1.10050385
81TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08961903
82SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.08262099
83SALL4_22934838_ChIP-ChIP_CD34+_Human1.07669687
84CMYC_18555785_Chip-Seq_ESCs_Mouse1.06988695
85SUZ12_18555785_Chip-Seq_ESCs_Mouse1.06216482
86* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.05997906
87TFEB_21752829_ChIP-Seq_HELA_Human1.05898197
88PU_27001747_Chip-Seq_BMDM_Mouse1.05714055
89IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.05006360
90CBP_20019798_ChIP-Seq_JUKART_Human1.05006360
91* SPI1_23547873_ChIP-Seq_NB4_Human1.04814770
92PIAS1_25552417_ChIP-Seq_VCAP_Human1.03955071
93SMAD4_21799915_ChIP-Seq_A2780_Human1.03698182
94EZH2_27294783_Chip-Seq_NPCs_Mouse1.03680499
95* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02103201
96PPAR_26484153_Chip-Seq_NCI-H1993_Human1.01893651
97PADI4_21655091_ChIP-ChIP_MCF-7_Human1.01652124
98EWS_26573619_Chip-Seq_HEK293_Human1.00456038
99ESR1_20079471_ChIP-ChIP_T-47D_Human1.00021585
100FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.98468440
101* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98445188
102SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.98008629
103STAT3_18555785_Chip-Seq_ESCs_Mouse0.96709518
104EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96165020
105MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.96003875
106AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.95786601
107TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94962807
108POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.94962807
109* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.94588072
110OCT4_18555785_Chip-Seq_ESCs_Mouse0.94584390
111P53_22387025_ChIP-Seq_ESCs_Mouse0.93827076
112LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.93244779
113DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.93178744
114NOTCH1_21737748_ChIP-Seq_TLL_Human0.92554807
115E2F1_18555785_Chip-Seq_ESCs_Mouse0.90787184
116NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.89959250
117NMYC_18555785_Chip-Seq_ESCs_Mouse0.89109021
118P300_18555785_Chip-Seq_ESCs_Mouse0.88996098
119PU1_27457419_Chip-Seq_LIVER_Mouse0.88862625
120PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.88647716
121ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.87956058
122E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.87107055
123CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.86987501
124VDR_24763502_ChIP-Seq_THP-1_Human0.85718995
125RUNX1_27457419_Chip-Seq_LIVER_Mouse0.84121681
126SPI1_23127762_ChIP-Seq_K562_Human0.84055599
127SUZ12_27294783_Chip-Seq_NPCs_Mouse0.84045080
128* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.83918934
129RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.83054510
130CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82877346
131SALL1_21062744_ChIP-ChIP_HESCs_Human0.82382550
132TAL1_26923725_Chip-Seq_HPCs_Mouse0.82224286
133EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.82087213
134SOX2_18555785_Chip-Seq_ESCs_Mouse0.82026370
135P53_22127205_ChIP-Seq_FIBROBLAST_Human0.80912518
136* RUNX1_22412390_ChIP-Seq_EML_Mouse0.80759185
137GATA2_22383799_ChIP-Seq_G1ME_Mouse0.78370459
138P300_19829295_ChIP-Seq_ESCs_Human0.77243586
139* FOXA1_25552417_ChIP-Seq_VCAP_Human0.76299549
140FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.76089402
141RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.75824623
142GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75487256
143* CDX2_22108803_ChIP-Seq_LS180_Human0.75127614
144NFE2_27457419_Chip-Seq_LIVER_Mouse0.74655563

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat5.11688360
2MP0000372_irregular_coat_pigmentation4.82437037
3MP0001835_abnormal_antigen_presentation4.39181719
4MP0000685_abnormal_immune_system4.26441640
5MP0002138_abnormal_hepatobiliary_system4.20694533
6MP0004510_myositis3.38759571
7MP0003806_abnormal_nucleotide_metabolis3.37991352
8MP0006054_spinal_hemorrhage3.36442090
9MP0002166_altered_tumor_susceptibility3.33861513
10MP0003191_abnormal_cellular_cholesterol3.24157513
11MP0005387_immune_system_phenotype3.18893861
12MP0001790_abnormal_immune_system3.18893861
13MP0005671_abnormal_response_to3.18324968
14MP0000015_abnormal_ear_pigmentation3.17987414
15MP0001348_abnormal_lacrimal_gland3.12555515
16MP0001873_stomach_inflammation3.12412849
17MP0002009_preneoplasia3.11343744
18MP0005310_abnormal_salivary_gland3.08676040
19MP0005408_hypopigmentation2.94045879
20MP0001800_abnormal_humoral_immune2.57802826
21MP0002006_tumorigenesis2.46778841
22MP0002148_abnormal_hypersensitivity_rea2.44466563
23MP0009785_altered_susceptibility_to2.37645104
24MP0005000_abnormal_immune_tolerance2.34423781
25MP0008260_abnormal_autophagy2.32342530
26MP0002723_abnormal_immune_serum2.26143932
27MP0002452_abnormal_antigen_presenting2.22327683
28MP0001346_abnormal_lacrimal_gland2.15702312
29MP0003763_abnormal_thymus_physiology2.10803676
30MP0001819_abnormal_immune_cell2.09507632
31MP0002420_abnormal_adaptive_immunity2.09146843
32MP0010352_gastrointestinal_tract_polyps2.08443342
33MP0002163_abnormal_gland_morphology2.07577216
34MP0005171_absent_coat_pigmentation2.06916209
35MP0003221_abnormal_cardiomyocyte_apopto2.03515590
36MP0000569_abnormal_digit_pigmentation2.03255388
37MP0006082_CNS_inflammation2.02092171
38MP0003656_abnormal_erythrocyte_physiolo1.99513448
39MP0008057_abnormal_DNA_replication1.96476292
40MP0000371_diluted_coat_color1.91588977
41MP0005025_abnormal_response_to1.88039919
42MP0002277_abnormal_respiratory_mucosa1.85970361
43MP0002876_abnormal_thyroid_physiology1.81542037
44MP0002419_abnormal_innate_immunity1.80117755
45MP0003950_abnormal_plasma_membrane1.76832245
46MP0002398_abnormal_bone_marrow1.74971458
47* MP0000716_abnormal_immune_system1.74714461
48MP0005164_abnormal_response_to1.68252263
49MP0005257_abnormal_intraocular_pressure1.67566436
50MP0002332_abnormal_exercise_endurance1.66343279
51MP0002877_abnormal_melanocyte_morpholog1.64680273
52MP0003436_decreased_susceptibility_to1.63031760
53MP0003183_abnormal_peptide_metabolism1.62444863
54MP0002102_abnormal_ear_morphology1.58492190
55MP0003303_peritoneal_inflammation1.54544200
56MP0004883_abnormal_blood_vessel1.52554779
57MP0005379_endocrine/exocrine_gland_phen1.51991469
58MP0003195_calcinosis1.51415132
59MP0004947_skin_inflammation1.51086725
60MP0000920_abnormal_myelination1.47366003
61MP0005248_abnormal_Harderian_gland1.46986284
62MP0008004_abnormal_stomach_pH1.46550028
63MP0005410_abnormal_fertilization1.43176289
64MP0003045_fibrosis1.40867894
65MP0010155_abnormal_intestine_physiology1.35077131
66MP0009697_abnormal_copulation1.31693777
67MP0008877_abnormal_DNA_methylation1.31580520
68* MP0002429_abnormal_blood_cell1.31300581
69MP0002405_respiratory_system_inflammati1.30352873
70MP0000465_gastrointestinal_hemorrhage1.25409385
71MP0003828_pulmonary_edema1.21296184
72MP0001845_abnormal_inflammatory_respons1.18711391
73MP0000689_abnormal_spleen_morphology1.18571410
74MP0004484_altered_response_of1.17946275
75MP0000858_altered_metastatic_potential1.17421487
76MP0003186_abnormal_redox_activity1.16712247
77MP0003453_abnormal_keratinocyte_physiol1.14394667
78MP0008438_abnormal_cutaneous_collagen1.14081832
79MP0002722_abnormal_immune_system1.13979482
80MP0002396_abnormal_hematopoietic_system1.13668571
81MP0000703_abnormal_thymus_morphology1.11737109
82MP0000383_abnormal_hair_follicle1.10867631
83MP0002139_abnormal_hepatobiliary_system1.09641457
84MP0003724_increased_susceptibility_to1.08610658
85MP0005647_abnormal_sex_gland1.06578592
86MP0001853_heart_inflammation1.03659936
87MP0005023_abnormal_wound_healing1.03533015
88MP0005464_abnormal_platelet_physiology1.03404400
89MP0001324_abnormal_eye_pigmentation1.00566874
90MP0003943_abnormal_hepatobiliary_system0.99496086
91MP0003136_yellow_coat_color0.98343798
92MP0002928_abnormal_bile_duct0.97579571
93MP0008469_abnormal_protein_level0.97106341
94MP0001191_abnormal_skin_condition0.95994745
95MP0005367_renal/urinary_system_phenotyp0.93885246
96MP0000516_abnormal_urinary_system0.93885246
97MP0001915_intracranial_hemorrhage0.93196692
98MP0010678_abnormal_skin_adnexa0.93026073
99MP0001851_eye_inflammation0.92437112
100MP0003866_abnormal_defecation0.91531706
101MP0005058_abnormal_lysosome_morphology0.91089873
102MP0003091_abnormal_cell_migration0.90523855
103MP0003690_abnormal_glial_cell0.90497666
104MP0003566_abnormal_cell_adhesion0.90285155
105MP0003172_abnormal_lysosome_physiology0.88529361
106MP0005197_abnormal_uvea_morphology0.87151202
107MP0000343_altered_response_to0.86890906
108MP0003252_abnormal_bile_duct0.84205129
109MP0010234_abnormal_vibrissa_follicle0.83965584
110MP0005376_homeostasis/metabolism_phenot0.83523930
111MP0000767_abnormal_smooth_muscle0.81322651
112MP0009333_abnormal_splenocyte_physiolog0.81063299
113MP0010368_abnormal_lymphatic_system0.80800336
114MP0009763_increased_sensitivity_to0.80657218
115MP0001186_pigmentation_phenotype0.80325491
116MP0002693_abnormal_pancreas_physiology0.79804058
117MP0000249_abnormal_blood_vessel0.78092990
118MP0005621_abnormal_cell_physiology0.76701889
119MP0005174_abnormal_tail_pigmentation0.75464855
120MP0000647_abnormal_sebaceous_gland0.75421022
121MP0005266_abnormal_metabolism0.75394918
122MP0002933_joint_inflammation0.75200569
123MP0001542_abnormal_bone_strength0.74494968
124MP0001533_abnormal_skeleton_physiology0.71972093
125MP0004381_abnormal_hair_follicle0.71310579
126MP0003300_gastrointestinal_ulcer0.71191652
127MP0000613_abnormal_salivary_gland0.69826996
128MP0001958_emphysema0.69233362
129MP0002060_abnormal_skin_morphology0.67293176
130MP0000470_abnormal_stomach_morphology0.66925764
131MP0003868_abnormal_feces_composition0.66828358
132MP0000604_amyloidosis0.66805342
133MP0001929_abnormal_gametogenesis0.66707765
134MP0003787_abnormal_imprinting0.66192060
135MP0005165_increased_susceptibility_to0.65095618
136MP0004808_abnormal_hematopoietic_stem0.64265656
137MP0009764_decreased_sensitivity_to0.61253283
138MP0001661_extended_life_span0.60865702
139MP0001879_abnormal_lymphatic_vessel0.60086650
140MP0004742_abnormal_vestibular_system0.57695837
141MP0008007_abnormal_cellular_replicative0.56867970
142MP0003698_abnormal_male_reproductive0.56319758
143MP0002998_abnormal_bone_remodeling0.55726260
144MP0001765_abnormal_ion_homeostasis0.55331132
145MP0001545_abnormal_hematopoietic_system0.54622486
146MP0005397_hematopoietic_system_phenotyp0.54622486
147MP0009765_abnormal_xenobiotic_induced0.53684504
148MP0001881_abnormal_mammary_gland0.53177073
149MP0005645_abnormal_hypothalamus_physiol0.53109529
150MP0001243_abnormal_dermal_layer0.51723864
151MP0003448_altered_tumor_morphology0.51576502
152MP0002095_abnormal_skin_pigmentation0.51466734
153MP0005075_abnormal_melanosome_morpholog0.49451322
154MP0010386_abnormal_urinary_bladder0.49033689
155MP0004782_abnormal_surfactant_physiolog0.47289625
156MP0008872_abnormal_physiological_respon0.46876066
157MP0000427_abnormal_hair_cycle0.46699258

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)4.61139229
2Absent/shortened dynein arms (HP:0200106)4.61139229
3Nasal polyposis (HP:0100582)4.36943889
4Degeneration of the lateral corticospinal tracts (HP:0002314)4.36175471
5Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.36175471
6Chronic otitis media (HP:0000389)4.13617564
7Chronic mucocutaneous candidiasis (HP:0002728)4.09767087
8Recurrent cutaneous fungal infections (HP:0011370)4.09767087
9Recurrent fungal infections (HP:0002841)4.08017377
10Recurrent viral infections (HP:0004429)4.06350668
11Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.99657819
12Recurrent bronchitis (HP:0002837)3.92865591
13Abnormal respiratory motile cilium physiology (HP:0012261)3.83971004
14Abnormal delayed hypersensitivity skin test (HP:0002963)3.76203316
15Agammaglobulinemia (HP:0004432)3.73745562
16Abnormal ciliary motility (HP:0012262)3.67523660
17Abnormality of the nasal mucosa (HP:0000433)3.51742476
18Retrobulbar optic neuritis (HP:0100654)3.45236285
19Optic neuritis (HP:0100653)3.45236285
20Bronchitis (HP:0012387)3.43055821
21Gastrointestinal stroma tumor (HP:0100723)3.40004709
22Patchy hypopigmentation of hair (HP:0011365)3.38430404
23Abnormal auditory evoked potentials (HP:0006958)3.35571259
24Aplasia/Hypoplasia of the macula (HP:0008059)3.33636602
25Increased IgM level (HP:0003496)3.25641393
26Chronic sinusitis (HP:0011109)3.23459924
27Abnormality of T cell number (HP:0011839)3.21378333
28Albinism (HP:0001022)3.19901376
29Abnormal respiratory epithelium morphology (HP:0012253)3.18901412
30Abnormal respiratory motile cilium morphology (HP:0005938)3.18901412
31Keratoconjunctivitis (HP:0001096)3.13493039
32Metaphyseal dysplasia (HP:0100255)3.13153524
33Bronchiectasis (HP:0002110)3.09938441
34Chronic diarrhea (HP:0002028)3.07571054
35Vasculitis (HP:0002633)3.06736387
36Recurrent sinusitis (HP:0011108)3.05129947
37Abnormality of the fingertips (HP:0001211)3.04508396
38White forelock (HP:0002211)3.01500328
39Ocular albinism (HP:0001107)3.01492106
40Tetraparesis (HP:0002273)3.00685191
41Recurrent skin infections (HP:0001581)2.98970820
42Colitis (HP:0002583)2.98832377
43Aplasia/Hypoplasia affecting the retina (HP:0008061)2.96132210
44Abnormality of the corticospinal tract (HP:0002492)2.94670094
45Abnormality of the fovea (HP:0000493)2.94516897
46Panhypogammaglobulinemia (HP:0003139)2.88026536
47Absent frontal sinuses (HP:0002688)2.87670408
48Elevated erythrocyte sedimentation rate (HP:0003565)2.87613043
49Generalized hypopigmentation (HP:0007513)2.86395489
50T lymphocytopenia (HP:0005403)2.83632035
51Blue irides (HP:0000635)2.83390275
52Hypergammaglobulinemia (HP:0010702)2.82953399
53Thyroiditis (HP:0100646)2.81938660
54Sensory axonal neuropathy (HP:0003390)2.81727960
55Autoimmune hemolytic anemia (HP:0001890)2.78661490
56Eosinophilia (HP:0001880)2.78512981
57Eczematoid dermatitis (HP:0000976)2.78320024
58Increased IgE level (HP:0003212)2.75278014
59Abnormality of the musculature of the pelvis (HP:0001469)2.72142162
60Abnormality of the hip-girdle musculature (HP:0001445)2.72142162
61Abnormality of eosinophils (HP:0001879)2.70419485
62Inflammation of the large intestine (HP:0002037)2.68459385
63Chronic bronchitis (HP:0004469)2.68341167
64Hypoplasia of the fovea (HP:0007750)2.62763293
65Aplasia/Hypoplasia of the fovea (HP:0008060)2.62763293
66Arterial thrombosis (HP:0004420)2.62635047
67Rhinitis (HP:0012384)2.61020766
68Thyroid carcinoma (HP:0002890)2.60247858
69Thrombocytosis (HP:0001894)2.58730357
70Myositis (HP:0100614)2.58060499
71Myocardial infarction (HP:0001658)2.56777883
72Bilateral sensorineural hearing impairment (HP:0008619)2.56267262
73Orchitis (HP:0100796)2.56088244
74Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.56038187
75Iris hypopigmentation (HP:0007730)2.55292728
76Asplenia (HP:0001746)2.55176324
77Freckling (HP:0001480)2.55031430
78Spondylolisthesis (HP:0003302)2.54510638
79Pulmonary infiltrates (HP:0002113)2.53128669
80Aplasia/Hypoplasia of the spleen (HP:0010451)2.50868461
81Amyotrophic lateral sclerosis (HP:0007354)2.50331634
82Recurrent bacterial skin infections (HP:0005406)2.49144901
83Neonatal respiratory distress (HP:0002643)2.47783561
84Mitral stenosis (HP:0001718)2.47740755
85Leukocytosis (HP:0001974)2.45431784
86Keratoconjunctivitis sicca (HP:0001097)2.44408715
87Vascular tortuosity (HP:0004948)2.43843654
88Cutaneous melanoma (HP:0012056)2.39670552
89Parakeratosis (HP:0001036)2.37684985
90Gastrointestinal inflammation (HP:0004386)2.37010257
91Subacute progressive viral hepatitis (HP:0006572)2.34906339
92Granulocytopenia (HP:0001913)2.34431703
93Abnormality of cells of the lymphoid lineage (HP:0012140)2.34322348
94Lymphopenia (HP:0001888)2.33445080
95Gingival bleeding (HP:0000225)2.33368739
96Abnormality of the vasculature of the conjunctiva (HP:0008054)2.33289056
97Fatigue (HP:0012378)2.33204979
98Decreased skull ossification (HP:0004331)2.32936639
99Abnormality of T cells (HP:0002843)2.32605959
100Osteolytic defects of the phalanges of the hand (HP:0009771)2.30802923
101Osteolytic defects of the hand bones (HP:0009699)2.30802923
102Recurrent abscess formation (HP:0002722)2.28573347
103Arterial tortuosity (HP:0005116)2.28538946
104Global brain atrophy (HP:0002283)2.26495036
105Gastrointestinal infarctions (HP:0005244)2.25223128
106Mediastinal lymphadenopathy (HP:0100721)2.24812722
107Conjunctival telangiectasia (HP:0000524)2.24143425
108Congenital sensorineural hearing impairment (HP:0008527)2.23108612
109Stomach cancer (HP:0012126)2.22843587
110Hematochezia (HP:0002573)2.22686569
111Atrophy/Degeneration involving motor neurons (HP:0007373)2.21800252
112IgG deficiency (HP:0004315)2.19791405
113Cardiovascular calcification (HP:0011915)2.19727723
114Encephalitis (HP:0002383)2.19192302
115Abnormal hair whorl (HP:0010721)2.16139419
116Meningitis (HP:0001287)2.14382294
117Degeneration of anterior horn cells (HP:0002398)2.13638172
118Abnormality of the anterior horn cell (HP:0006802)2.13638172
119Abnormality of T cell physiology (HP:0011840)2.13240192
120Abnormality of macrophages (HP:0004311)2.12259712
121Aortic dissection (HP:0002647)2.11476516
122Recurrent pneumonia (HP:0006532)2.09817665
123Cerebral hemorrhage (HP:0001342)2.09302614
124Vascular calcification (HP:0004934)2.07143231
125Thick nail (HP:0001805)2.07063191
126Choroideremia (HP:0001139)2.06829203
127Subaortic stenosis (HP:0001682)2.06580927
128Abnormality of the left ventricular outflow tract (HP:0011103)2.06580927
129Acute myeloid leukemia (HP:0004808)2.06352038
130Stomatitis (HP:0010280)2.05786266
131Severe combined immunodeficiency (HP:0004430)2.04921311
132Thoracolumbar scoliosis (HP:0002944)2.04597245
133Periodontitis (HP:0000704)2.02114180
134Amaurosis fugax (HP:0100576)2.01042893
135Peritonitis (HP:0002586)2.00203550
136Emphysema (HP:0002097)2.00082392
137Hypoplastic scapulae (HP:0000882)1.99546966
138Aplasia/Hypoplasia of the scapulae (HP:0006713)1.99546966
139Hypopigmentation of the fundus (HP:0007894)1.99502923
140Spontaneous abortion (HP:0005268)1.98735139
141Papillary thyroid carcinoma (HP:0002895)1.98511642
142Anhidrosis (HP:0000970)1.98112636
143Abnormality of glycolipid metabolism (HP:0010969)1.97782619
144Abnormality of liposaccharide metabolism (HP:0010968)1.97782619
145Abnormality of glycosphingolipid metabolism (HP:0004343)1.97782619
146Abnormality of B cell number (HP:0010975)1.97069722
147B lymphocytopenia (HP:0010976)1.97069722
148Abnormality of skull ossification (HP:0002703)1.96913503
149Lip pit (HP:0100267)1.96350649
150Abnormality of the frontal sinuses (HP:0002687)1.96341021
151Infertility (HP:0000789)1.95822370
152Neoplasm of the tracheobronchial system (HP:0100552)1.94954491
153Polyneuropathy (HP:0001271)1.93962182
154Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.92900808
155Deep philtrum (HP:0002002)1.92342994
156Stillbirth (HP:0003826)1.92107223
157Keratitis (HP:0000491)1.90952533
158Long clavicles (HP:0000890)1.89937383
159Medial flaring of the eyebrow (HP:0010747)1.87836295
160Papilledema (HP:0001085)1.87061150
161Curly hair (HP:0002212)1.85941553
162Portal hypertension (HP:0001409)1.85914114
163Heterochromia iridis (HP:0001100)1.85373692
164Male infertility (HP:0003251)1.83958319
165Pelvic girdle muscle weakness (HP:0003749)1.81642101
166Recurrent lower respiratory tract infections (HP:0002783)1.81336570
167Abnormality of the common coagulation pathway (HP:0010990)1.80734432
168Abnormality of the costochondral junction (HP:0000919)1.79917590
169Autoamputation (HP:0001218)1.79684354
170Aortic aneurysm (HP:0004942)1.78791744
171IgA deficiency (HP:0002720)1.78533535
172Generalized hypopigmentation of hair (HP:0011358)1.77181191
173Facial diplegia (HP:0001349)1.75698317
174Hypoplasia of the thymus (HP:0000778)1.74194590
175Vacuolated lymphocytes (HP:0001922)1.73740791
176Orthostatic hypotension (HP:0001278)1.72420630
177Micronodular cirrhosis (HP:0001413)1.71921676
178Ascites (HP:0001541)1.69545671
179Thickened calvaria (HP:0002684)1.69515497
180Exocrine pancreatic insufficiency (HP:0001738)1.68966678
181Bladder carcinoma (HP:0002862)1.68479787
182Bladder neoplasm (HP:0009725)1.68479787
183Mucosal telangiectasiae (HP:0100579)1.67757660
184Limb-girdle muscle weakness (HP:0003325)1.67539778

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K145.17860625
2TRIM283.81854517
3TYK23.70006985
4SIK33.31426958
5JAK33.09186984
6MAP3K133.04554411
7IKBKB3.00719702
8EPHB12.92332547
9LATS12.79206904
10IKBKE2.72448739
11STK392.52267346
12ACVR1B2.51568555
13JAK12.48278631
14CHUK2.42713443
15FGFR42.38353445
16WEE12.33917114
17AKT32.20829725
18KIT2.18687595
19EIF2AK32.18192858
20IRAK42.05259915
21BCR2.04797146
22PLK22.00977601
23MAP3K121.99128717
24TBK11.98089101
25MAPK151.95175190
26NEK91.91286050
27STK38L1.89528623
28FGFR21.88036557
29KSR11.80480928
30PKN11.77422274
31CDK61.73851400
32INSRR1.72843394
33OXSR11.69676597
34FGR1.68773437
35FGFR31.67380831
36FLT31.61824171
37MAP3K31.59761233
38BMPR21.55545768
39EPHA31.54617685
40MAP3K61.52988897
41STK31.50444539
42ITK1.49011889
43BRSK21.41550557
44WNK11.40595603
45FRK1.39776796
46MAP4K11.38649587
47TXK1.36945816
48MST1R1.36603291
49STK101.36217921
50EIF2AK11.32514318
51CSF1R1.30576012
52NEK61.30322455
53PRKCQ1.29999714
54MARK31.28031653
55STK381.20811734
56MAP3K21.17856280
57ICK1.14846151
58BTK1.10583225
59JAK21.08123374
60LCK1.06631795
61MYLK1.06291518
62CDK191.06048831
63TEC1.05545222
64NLK1.04132097
65BMPR1B1.04081774
66RPS6KA51.03615575
67TNIK1.00461474
68SYK1.00201616
69IRAK10.99517389
70WNK40.99371324
71PRKAA20.99276380
72FER0.96710837
73MAP3K50.96656429
74MAP3K40.96424212
75GRK60.95735914
76CLK10.91482550
77PLK30.89502763
78ARAF0.88591869
79CAMKK20.84872156
80GRK70.82348140
81CSK0.78703735
82ERBB40.78385480
83TGFBR20.78004332
84MST40.77727261
85PAK40.75030715
86EGFR0.74193058
87TAOK30.72875082
88STK240.68683710
89PDK20.67176181
90HIPK20.65524910
91MATK0.65449254
92ZAP700.63978723
93MAP2K70.62587985
94EIF2AK20.60604156
95BLK0.59523601
96PIM10.57892677
97CCNB10.53787332
98MAPK70.53671941
99PTK2B0.52493526
100MELK0.50546757
101LYN0.47805391
102HCK0.47742656
103GSK3A0.47549621
104RET0.47423021
105PAK30.46333489
106TRPM70.45024586
107MAP2K60.44266260
108DYRK1B0.44205636
109PTK60.44025484
110SGK10.40549601
111MET0.39754742
112CSNK1A1L0.39523919
113NEK10.37975480
114ERBB30.37156343
115MAP3K70.37047139
116GRK10.36347065
117BRD40.35911123
118STK40.35147974
119MAP2K40.34469398
120CDK120.33970883
121MAPKAPK20.33872613
122CDK90.33620357
123YES10.33467757
124GRK50.32973259
125PDGFRA0.32738564
126PASK0.32205777
127RPS6KA40.32013346
128PDK10.31829558
129MAP2K30.31259152
130SCYL20.30993347
131PIK3CG0.30831368
132NUAK10.30479207
133DDR20.29421277
134PRKCD0.29218736
135RIPK40.28983608
136CASK0.28955860
137PBK0.27697329
138ADRBK10.27226548
139INSR0.27047230
140PRKCE0.26882381
141MOS0.25480662
142SGK20.25459532
143ABL10.25434346
144PIM20.25354785
145PDGFRB0.24892706
146CDK80.24828342
147TYRO30.23409950
148SGK2230.23125725
149SGK4940.23125725
150IGF1R0.21601415
151CDC42BPA0.20795444

Predicted pathways (KEGG)

RankGene SetZ-score
1Intestinal immune network for IgA production_Homo sapiens_hsa046723.43509950
2* NF-kappa B signaling pathway_Homo sapiens_hsa040643.42560396
3Primary immunodeficiency_Homo sapiens_hsa053403.30464251
4Allograft rejection_Homo sapiens_hsa053303.10031336
5Autoimmune thyroid disease_Homo sapiens_hsa053202.64381984
6* NOD-like receptor signaling pathway_Homo sapiens_hsa046212.48625452
7Measles_Homo sapiens_hsa051622.40736774
8Antigen processing and presentation_Homo sapiens_hsa046122.38049110
9Leishmaniasis_Homo sapiens_hsa051402.35624279
10Graft-versus-host disease_Homo sapiens_hsa053322.22750573
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.14702629
12Sulfur metabolism_Homo sapiens_hsa009202.14268645
13B cell receptor signaling pathway_Homo sapiens_hsa046622.10160061
14RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.09992076
15T cell receptor signaling pathway_Homo sapiens_hsa046602.02771305
16Osteoclast differentiation_Homo sapiens_hsa043801.98363525
17Steroid biosynthesis_Homo sapiens_hsa001001.95154302
18Jak-STAT signaling pathway_Homo sapiens_hsa046301.91936777
19* TNF signaling pathway_Homo sapiens_hsa046681.84634023
20* Toxoplasmosis_Homo sapiens_hsa051451.79958844
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.75783902
22Chemokine signaling pathway_Homo sapiens_hsa040621.69962201
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.69180809
24Herpes simplex infection_Homo sapiens_hsa051681.61984702
25Influenza A_Homo sapiens_hsa051641.54439487
26p53 signaling pathway_Homo sapiens_hsa041151.46079113
27Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.44847169
28Type I diabetes mellitus_Homo sapiens_hsa049401.42485310
29Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.40363262
30Rheumatoid arthritis_Homo sapiens_hsa053231.39523060
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.38649833
32Asthma_Homo sapiens_hsa053101.37674821
33Shigellosis_Homo sapiens_hsa051311.35676109
34Hematopoietic cell lineage_Homo sapiens_hsa046401.34502563
35Ether lipid metabolism_Homo sapiens_hsa005651.33864841
36Prolactin signaling pathway_Homo sapiens_hsa049171.29219328
37* Apoptosis_Homo sapiens_hsa042101.29050397
38SNARE interactions in vesicular transport_Homo sapiens_hsa041301.26458132
39Protein export_Homo sapiens_hsa030601.26127452
40Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.23089331
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.19379142
42Hepatitis C_Homo sapiens_hsa051601.19080437
43Malaria_Homo sapiens_hsa051441.17549866
44Phagosome_Homo sapiens_hsa041451.17513098
45Legionellosis_Homo sapiens_hsa051341.15864027
46Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.14282484
47Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.13301739
48Thyroid cancer_Homo sapiens_hsa052161.06908919
49Epstein-Barr virus infection_Homo sapiens_hsa051691.06743632
50Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.03357963
51African trypanosomiasis_Homo sapiens_hsa051431.01918822
52Transcriptional misregulation in cancer_Homo sapiens_hsa052021.01829301
53Pertussis_Homo sapiens_hsa051330.99588053
54Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.99208477
55Tuberculosis_Homo sapiens_hsa051520.98558992
56Complement and coagulation cascades_Homo sapiens_hsa046100.94508622
57Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.93596804
58Amoebiasis_Homo sapiens_hsa051460.91561278
59Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.91066212
60Linoleic acid metabolism_Homo sapiens_hsa005910.90307676
61Non-homologous end-joining_Homo sapiens_hsa034500.89849541
62Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.88964893
63Phosphatidylinositol signaling system_Homo sapiens_hsa040700.88588025
64Proteoglycans in cancer_Homo sapiens_hsa052050.88565298
65Dorso-ventral axis formation_Homo sapiens_hsa043200.88067052
66Hepatitis B_Homo sapiens_hsa051610.86590798
67Acute myeloid leukemia_Homo sapiens_hsa052210.85988554
68Salmonella infection_Homo sapiens_hsa051320.85578787
69Viral carcinogenesis_Homo sapiens_hsa052030.85511564
70Circadian rhythm_Homo sapiens_hsa047100.85350351
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.85221003
72Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.84077755
73Non-small cell lung cancer_Homo sapiens_hsa052230.81747303
74Adherens junction_Homo sapiens_hsa045200.81746335
75MAPK signaling pathway_Homo sapiens_hsa040100.79436338
76Fatty acid biosynthesis_Homo sapiens_hsa000610.78424812
77Proteasome_Homo sapiens_hsa030500.77806262
78* Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.77588734
79Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.77510257
80Collecting duct acid secretion_Homo sapiens_hsa049660.76941040
81* Focal adhesion_Homo sapiens_hsa045100.72187089
82Maturity onset diabetes of the young_Homo sapiens_hsa049500.72157082
83Vibrio cholerae infection_Homo sapiens_hsa051100.71739251
84Viral myocarditis_Homo sapiens_hsa054160.71344207
85Sphingolipid signaling pathway_Homo sapiens_hsa040710.71123170
86Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.70523545
87Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69007720
88Leukocyte transendothelial migration_Homo sapiens_hsa046700.68937812
89TGF-beta signaling pathway_Homo sapiens_hsa043500.68059498
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67676488
91Ovarian steroidogenesis_Homo sapiens_hsa049130.67508419
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66652101
93Inositol phosphate metabolism_Homo sapiens_hsa005620.66427423
94Regulation of autophagy_Homo sapiens_hsa041400.62569547
95Renal cell carcinoma_Homo sapiens_hsa052110.62047396
96* Small cell lung cancer_Homo sapiens_hsa052220.61983379
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.60537574
98Other glycan degradation_Homo sapiens_hsa005110.58984808
99HTLV-I infection_Homo sapiens_hsa051660.57992495
100Bladder cancer_Homo sapiens_hsa052190.56940395
101Type II diabetes mellitus_Homo sapiens_hsa049300.55867371
102Colorectal cancer_Homo sapiens_hsa052100.53851067
103Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.52823634
104Chronic myeloid leukemia_Homo sapiens_hsa052200.52156378
105Endocytosis_Homo sapiens_hsa041440.52088323
106Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.51730049
107Drug metabolism - other enzymes_Homo sapiens_hsa009830.51606781
108Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.51164413
109Pancreatic cancer_Homo sapiens_hsa052120.50661686
110Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50455648
111Starch and sucrose metabolism_Homo sapiens_hsa005000.48504726
112Insulin resistance_Homo sapiens_hsa049310.48184887
113Platelet activation_Homo sapiens_hsa046110.48081008
114AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.47952695
115MicroRNAs in cancer_Homo sapiens_hsa052060.46657086
116Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42070082
117Prostate cancer_Homo sapiens_hsa052150.39704469
118Ras signaling pathway_Homo sapiens_hsa040140.39463595
119ABC transporters_Homo sapiens_hsa020100.39329027
120FoxO signaling pathway_Homo sapiens_hsa040680.38568738
121Lysosome_Homo sapiens_hsa041420.37738913
122Fatty acid elongation_Homo sapiens_hsa000620.37671993
123Basal transcription factors_Homo sapiens_hsa030220.36825945
124Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.34432216
125Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.30993934
126Systemic lupus erythematosus_Homo sapiens_hsa053220.30823530
127Staphylococcus aureus infection_Homo sapiens_hsa051500.29935281
128Regulation of actin cytoskeleton_Homo sapiens_hsa048100.25877771
129* Pathways in cancer_Homo sapiens_hsa052000.25226856
130Neurotrophin signaling pathway_Homo sapiens_hsa047220.24678250
131Arachidonic acid metabolism_Homo sapiens_hsa005900.23772117
132Sphingolipid metabolism_Homo sapiens_hsa006000.23367898
133Renin secretion_Homo sapiens_hsa049240.22815335

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »