BIN3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene is a member of the BAR domain protein family. The encoded protein is comprised solely of a BAR domain which is predicted to form coiled-coil structures and proposed to mediate dimerization, sense and induce membrane curvature, and bind small GTPases. BAR domain proteins have been implicated in endocytosis, intracellular transport, and a diverse set of other processes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.17394903
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.07391876
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.34596124
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.34596124
5positive regulation of gamma-delta T cell activation (GO:0046645)4.27197973
6antigen processing and presentation of endogenous antigen (GO:0019883)4.12227934
7DNA deamination (GO:0045006)4.10894366
8negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.98839497
9negative regulation of cell killing (GO:0031342)3.98839497
10Arp2/3 complex-mediated actin nucleation (GO:0034314)3.81297090
11viral transcription (GO:0019083)3.79343921
12positive regulation of B cell differentiation (GO:0045579)3.68012409
13tolerance induction (GO:0002507)3.67175812
14detection of other organism (GO:0098543)3.66414819
15immunoglobulin mediated immune response (GO:0016064)3.66284103
16detection of bacterium (GO:0016045)3.62661364
17translational termination (GO:0006415)3.61048678
18negative regulation of interleukin-12 production (GO:0032695)3.57221098
19B cell mediated immunity (GO:0019724)3.50827235
20regulation of B cell receptor signaling pathway (GO:0050855)3.44676852
21SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.39503342
22regulation of B cell differentiation (GO:0045577)3.36253023
23positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.35657122
24response to interferon-beta (GO:0035456)3.31586842
25neutrophil activation involved in immune response (GO:0002283)3.31304415
26cotranslational protein targeting to membrane (GO:0006613)3.29945787
27protein targeting to ER (GO:0045047)3.28106524
28cellular response to interleukin-15 (GO:0071350)3.22810134
29negative regulation of phagocytosis (GO:0050765)3.21884146
30defense response to protozoan (GO:0042832)3.20348878
31translational elongation (GO:0006414)3.18021853
32granulocyte activation (GO:0036230)3.15906912
33protein localization to endoplasmic reticulum (GO:0070972)3.13043953
34leukocyte degranulation (GO:0043299)3.12854078
35establishment of protein localization to endoplasmic reticulum (GO:0072599)3.11530051
36leukocyte aggregation (GO:0070486)3.10437490
37endosome to pigment granule transport (GO:0043485)3.09699827
38endosome to melanosome transport (GO:0035646)3.09699827
39negative T cell selection (GO:0043383)3.07050004
40response to protozoan (GO:0001562)3.04246222
41response to interleukin-15 (GO:0070672)3.03274858
42ribosomal small subunit biogenesis (GO:0042274)3.02843215
43response to peptidoglycan (GO:0032494)3.02000680
44negative thymic T cell selection (GO:0045060)3.01039203
45respiratory burst (GO:0045730)3.00934901
46maturation of SSU-rRNA (GO:0030490)3.00002798
47negative regulation of erythrocyte differentiation (GO:0045647)2.99591434
48negative regulation of B cell apoptotic process (GO:0002903)2.98848525
49myeloid dendritic cell activation (GO:0001773)2.95706709
50cellular response to type I interferon (GO:0071357)2.92023916
51type I interferon signaling pathway (GO:0060337)2.92023916
52antigen processing and presentation via MHC class Ib (GO:0002475)2.90856783
53response to type I interferon (GO:0034340)2.90718031
54regulation of dendritic cell antigen processing and presentation (GO:0002604)2.90595442
55negative regulation of interleukin-1 production (GO:0032692)2.90394216
56detection of external biotic stimulus (GO:0098581)2.89589040
57negative regulation of innate immune response (GO:0045824)2.89517392
58modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.89434522
59positive regulation by organism of defense response of other organism involved in symbiotic interact2.89434522
60modulation by symbiont of host immune response (GO:0052553)2.89434522
61positive regulation by symbiont of host defense response (GO:0052509)2.89434522
62modulation by symbiont of host defense response (GO:0052031)2.89434522
63modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.89434522
64cytidine deamination (GO:0009972)2.89222631
65cytidine metabolic process (GO:0046087)2.89222631
66cytidine catabolic process (GO:0006216)2.89222631
67viral life cycle (GO:0019058)2.88422385
68cellular response to interferon-beta (GO:0035458)2.88021716
69regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.86672236
70response to host immune response (GO:0052572)2.85619060
71response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.85619060
72positive regulation of natural killer cell differentiation (GO:0032825)2.84829504
73negative regulation of myeloid cell apoptotic process (GO:0033033)2.84158240
74cellular extravasation (GO:0045123)2.83551431
75regulation of gamma-delta T cell activation (GO:0046643)2.83469215
76regulation of gamma-delta T cell differentiation (GO:0045586)2.83400420
77positive thymic T cell selection (GO:0045059)2.82350600
78negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.80484656
79actin nucleation (GO:0045010)2.80294344
80cellular response to zinc ion (GO:0071294)2.80209305
81negative regulation of interleukin-1 beta production (GO:0032691)2.80053489
82purine deoxyribonucleotide catabolic process (GO:0009155)2.79815612
83regulation of B cell apoptotic process (GO:0002902)2.79448947
84nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.79125811
85mast cell activation (GO:0045576)2.77880590
86positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.77763847
87regulation of interferon-beta biosynthetic process (GO:0045357)2.75343716
88purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.74017316
89negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.73431695
90positive regulation of interferon-alpha production (GO:0032727)2.72030761
91negative regulation of lymphocyte mediated immunity (GO:0002707)2.71505995
92definitive hemopoiesis (GO:0060216)2.71210205
93B cell receptor signaling pathway (GO:0050853)2.70973334
94regulation of antigen processing and presentation (GO:0002577)2.70672088
95NIK/NF-kappaB signaling (GO:0038061)2.70218106
96platelet dense granule organization (GO:0060155)2.70113844
97regulation of natural killer cell differentiation (GO:0032823)2.69442126
98regulation of T cell mediated cytotoxicity (GO:0001914)2.67851567
99negative regulation of T cell mediated immunity (GO:0002710)2.67510147
100response to interferon-alpha (GO:0035455)2.67349499
101deoxyribonucleotide catabolic process (GO:0009264)2.66047818
102megakaryocyte development (GO:0035855)2.65498550
103positive regulation of T cell mediated cytotoxicity (GO:0001916)2.65019257
104proteasome assembly (GO:0043248)2.64870520
105cellular protein complex disassembly (GO:0043624)2.64823359
106regulation of tolerance induction (GO:0002643)2.64732045
107regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.63978483
108interferon-gamma production (GO:0032609)2.63931439
109T cell migration (GO:0072678)2.63643434
110cell wall macromolecule catabolic process (GO:0016998)2.63023385
111leukocyte migration involved in inflammatory response (GO:0002523)2.62738665
112translational initiation (GO:0006413)2.62261602
113positive regulation of macrophage differentiation (GO:0045651)2.62208826
114negative regulation of alpha-beta T cell activation (GO:0046636)2.60867177
115regulation of mast cell degranulation (GO:0043304)2.60810402
116mast cell activation involved in immune response (GO:0002279)2.60545807
117mast cell degranulation (GO:0043303)2.60545807
118negative regulation of leukocyte mediated immunity (GO:0002704)2.60406888
119regulation of chemokine biosynthetic process (GO:0045073)2.59301799
120negative regulation of interleukin-6 production (GO:0032715)2.58857483
121pyrimidine ribonucleoside catabolic process (GO:0046133)2.57084454
122regulation of interferon-alpha production (GO:0032647)2.56272955
123regulation of alpha-beta T cell proliferation (GO:0046640)2.55832009
124regulation of necroptotic process (GO:0060544)2.55687531
125myeloid dendritic cell differentiation (GO:0043011)2.55406160
126regulation of mast cell activation (GO:0033003)2.54272166
127interferon-gamma-mediated signaling pathway (GO:0060333)2.53877290
128detection of biotic stimulus (GO:0009595)2.52986988
129neutrophil mediated immunity (GO:0002446)2.52476764
130positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.52110397
131antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.51882768
132response to muramyl dipeptide (GO:0032495)2.51570939
133mature B cell differentiation involved in immune response (GO:0002313)2.49747164
134regulation of germinal center formation (GO:0002634)2.49431419
135telomere maintenance via semi-conservative replication (GO:0032201)2.49355072
136positive regulation of antigen processing and presentation (GO:0002579)2.49326872
137regulation of mast cell activation involved in immune response (GO:0033006)2.49242330
138macrophage activation involved in immune response (GO:0002281)2.48985868
139T cell homeostasis (GO:0043029)2.47193306
140positive regulation of granulocyte differentiation (GO:0030854)2.46334467
141CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.45520315
142T cell apoptotic process (GO:0070231)2.45409129
143production of molecular mediator involved in inflammatory response (GO:0002532)2.43803948
144DNA strand elongation involved in DNA replication (GO:0006271)2.43557954
145antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.42883803
146regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.42542108
147regulation of erythrocyte differentiation (GO:0045646)2.41268508
148cellular response to exogenous dsRNA (GO:0071360)2.41127844
149lymphoid progenitor cell differentiation (GO:0002320)2.40305076
150neutrophil activation (GO:0042119)2.39860565
151positive regulation of interferon-beta production (GO:0032728)2.36449981
152angiogenesis involved in wound healing (GO:0060055)2.35705449
153necroptotic process (GO:0070266)2.35454115
154myeloid cell activation involved in immune response (GO:0002275)2.35158613
155DNA strand elongation (GO:0022616)2.34927848
156protein complex disassembly (GO:0043241)2.34626228
157natural killer cell mediated cytotoxicity (GO:0042267)2.33690252

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.49514313
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.08078293
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.45566792
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.23676310
5* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.03081931
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.86183705
7BP1_19119308_ChIP-ChIP_Hs578T_Human2.81509869
8SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.77437453
9SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.69801196
10SCL_19346495_ChIP-Seq_HPC-7_Human2.64645698
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.62828208
12GATA1_22025678_ChIP-Seq_K562_Human2.54842646
13MYB_21317192_ChIP-Seq_ERMYB_Mouse2.51468898
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.48029188
15* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.38735744
16SPI1_23547873_ChIP-Seq_NB4_Human2.35694979
17* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.34715547
18FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.16021213
19STAT4_19710469_ChIP-ChIP_TH1__Mouse2.13778262
20* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.12676566
21* GABP_17652178_ChIP-ChIP_JURKAT_Human2.11288930
22VDR_21846776_ChIP-Seq_THP-1_Human2.11127411
23MYC_18555785_ChIP-Seq_MESCs_Mouse2.08708895
24IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.08240981
25IRF8_27001747_Chip-Seq_BMDM_Mouse2.05813325
26* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.04613008
27* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.02555752
28MYB_26560356_Chip-Seq_TH2_Human1.98982650
29MYC_22102868_ChIP-Seq_BL_Human1.97218745
30FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.96588890
31FOXM1_23109430_ChIP-Seq_U2OS_Human1.95243950
32ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.93234567
33EGR1_19374776_ChIP-ChIP_THP-1_Human1.90304274
34E2F4_17652178_ChIP-ChIP_JURKAT_Human1.86033985
35SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.84065785
36CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.84051344
37HOXB4_20404135_ChIP-ChIP_EML_Mouse1.78349233
38EST1_17652178_ChIP-ChIP_JURKAT_Human1.77133948
39ERG_20887958_ChIP-Seq_HPC-7_Mouse1.76641705
40RUNX1_22412390_ChIP-Seq_EML_Mouse1.75825892
41STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.74844581
42MAF_26560356_Chip-Seq_TH1_Human1.73589168
43BRD4_27068464_Chip-Seq_AML-cells_Mouse1.73538830
44NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.72512286
45VDR_23849224_ChIP-Seq_CD4+_Human1.69374060
46* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.69200703
47VDR_24763502_ChIP-Seq_THP-1_Human1.68754330
48MYB_26560356_Chip-Seq_TH1_Human1.66301911
49SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.60837015
50E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.58572824
51NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.53242465
52JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.52497341
53MYC_18358816_ChIP-ChIP_MESCs_Mouse1.51453311
54UTX_26944678_Chip-Seq_JUKART_Human1.48835259
55KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.48644762
56GATA3_26560356_Chip-Seq_TH2_Human1.46819571
57CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.46539065
58ETS1_20019798_ChIP-Seq_JURKAT_Human1.45699502
59PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.44810200
60FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.44353139
61GATA2_22383799_ChIP-Seq_G1ME_Mouse1.41181388
62NOTCH1_21737748_ChIP-Seq_TLL_Human1.40500327
63BCL6_27268052_Chip-Seq_Bcells_Human1.40195384
64* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.39999786
65GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.39861331
66STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.37989248
67FOXP3_21729870_ChIP-Seq_TREG_Human1.37449882
68GATA1_22383799_ChIP-Seq_G1ME_Mouse1.36545764
69* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.34784698
70FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.33849097
71TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33657532
72CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.30815055
73XRN2_22483619_ChIP-Seq_HELA_Human1.30764669
74ELK1_19687146_ChIP-ChIP_HELA_Human1.30727914
75* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30554276
76MYC_19030024_ChIP-ChIP_MESCs_Mouse1.29922323
77* ELF1_20517297_ChIP-Seq_JURKAT_Human1.28163629
78TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.27257435
79* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.24131978
80SRF_21415370_ChIP-Seq_HL-1_Mouse1.23961666
81CIITA_25753668_ChIP-Seq_RAJI_Human1.22383977
82RUNX_20019798_ChIP-Seq_JUKART_Human1.20847602
83EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.20412049
84YY1_21170310_ChIP-Seq_MESCs_Mouse1.20076652
85SPI1_23127762_ChIP-Seq_K562_Human1.19587479
86NELFA_20434984_ChIP-Seq_ESCs_Mouse1.19282225
87MAF_26560356_Chip-Seq_TH2_Human1.18600452
88* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.17739475
89TCF7_22412390_ChIP-Seq_EML_Mouse1.17127933
90MYC_19079543_ChIP-ChIP_MESCs_Mouse1.16031684
91CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15586830
92E2F1_18555785_ChIP-Seq_MESCs_Mouse1.15562081
93BCOR_27268052_Chip-Seq_Bcells_Human1.15485437
94CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15482274
95E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.15382417
96PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15275107
97* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.14768109
98HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.13239152
99PU_27001747_Chip-Seq_BMDM_Mouse1.12076237
100BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.11553505
101PU.1_20513432_ChIP-Seq_Bcells_Mouse1.10484217
102* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.10333368
103TFEB_21752829_ChIP-Seq_HELA_Human1.08736892
104* GABP_19822575_ChIP-Seq_HepG2_Human1.08711254
105E2F1_21310950_ChIP-Seq_MCF-7_Human1.07887612
106DCP1A_22483619_ChIP-Seq_HELA_Human1.06026343
107CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03978804
108* P300_27268052_Chip-Seq_Bcells_Human1.03373557
109RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.02238598
110* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.02169285
111GATA3_27048872_Chip-Seq_THYMUS_Human1.01827899
112CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.01775836
113PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01748551
114SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01533295
115STAT1_20625510_ChIP-Seq_HELA_Human1.00849323
116STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.00733972
117CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00150019
118CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.99108506
119HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.96762362
120NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.95611887
121TTF2_22483619_ChIP-Seq_HELA_Human0.94584805
122PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94579502

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.97666009
2MP0009785_altered_susceptibility_to3.06493183
3MP0003436_decreased_susceptibility_to2.86853348
4MP0002396_abnormal_hematopoietic_system2.85884062
5MP0003806_abnormal_nucleotide_metabolis2.83230195
6MP0000685_abnormal_immune_system2.73481830
7MP0005671_abnormal_response_to2.64477607
8MP0005025_abnormal_response_to2.59293732
9MP0002148_abnormal_hypersensitivity_rea2.53575823
10MP0001800_abnormal_humoral_immune2.49770229
11MP0002452_abnormal_antigen_presenting2.46574373
12MP0002419_abnormal_innate_immunity2.45554999
13MP0005000_abnormal_immune_tolerance2.41498476
14MP0003763_abnormal_thymus_physiology2.32759941
15MP0002420_abnormal_adaptive_immunity2.28526610
16MP0002723_abnormal_immune_serum2.28171222
17MP0001819_abnormal_immune_cell2.28015808
18MP0005464_abnormal_platelet_physiology2.27620244
19MP0001853_heart_inflammation2.26776106
20MP0009333_abnormal_splenocyte_physiolog2.24441470
21MP0005387_immune_system_phenotype2.18678270
22MP0001790_abnormal_immune_system2.18678270
23MP0002398_abnormal_bone_marrow2.15733928
24MP0002166_altered_tumor_susceptibility2.08877353
25MP0001545_abnormal_hematopoietic_system2.04014960
26MP0005397_hematopoietic_system_phenotyp2.04014960
27MP0003724_increased_susceptibility_to2.01222099
28MP0003693_abnormal_embryo_hatching1.98718479
29MP0004808_abnormal_hematopoietic_stem1.90745369
30MP0000716_abnormal_immune_system1.88958098
31MP0000490_abnormal_crypts_of1.88743071
32MP0005174_abnormal_tail_pigmentation1.87965534
33MP0010155_abnormal_intestine_physiology1.86999913
34* MP0000689_abnormal_spleen_morphology1.84510852
35MP0002006_tumorigenesis1.82854236
36* MP0002405_respiratory_system_inflammati1.79017050
37MP0000465_gastrointestinal_hemorrhage1.78146978
38* MP0002722_abnormal_immune_system1.74886703
39* MP0002429_abnormal_blood_cell1.71532753
40* MP0001845_abnormal_inflammatory_respons1.67465046
41MP0003303_peritoneal_inflammation1.66023254
42MP0001873_stomach_inflammation1.65726120
43MP0004381_abnormal_hair_follicle1.63963360
44MP0006082_CNS_inflammation1.63301529
45MP0002277_abnormal_respiratory_mucosa1.56507404
46MP0009840_abnormal_foam_cell1.54504298
47MP0008260_abnormal_autophagy1.52364918
48MP0002095_abnormal_skin_pigmentation1.51397184
49MP0006054_spinal_hemorrhage1.49048277
50MP0004947_skin_inflammation1.48580224
51MP0010094_abnormal_chromosome_stability1.42104082
52MP0003656_abnormal_erythrocyte_physiolo1.36482418
53MP0001533_abnormal_skeleton_physiology1.36397677
54MP0002132_abnormal_respiratory_system1.36325876
55MP0000015_abnormal_ear_pigmentation1.35096012
56MP0008469_abnormal_protein_level1.33169977
57MP0002933_joint_inflammation1.32647796
58MP0000703_abnormal_thymus_morphology1.32524426
59MP0002653_abnormal_ependyma_morphology1.28395429
60MP0000858_altered_metastatic_potential1.28293128
61MP0005171_absent_coat_pigmentation1.28284175
62MP0005058_abnormal_lysosome_morphology1.27383527
63MP0005075_abnormal_melanosome_morpholog1.27267126
64MP0003077_abnormal_cell_cycle1.26875649
65MP0002102_abnormal_ear_morphology1.25171648
66MP0000343_altered_response_to1.23627342
67MP0009764_decreased_sensitivity_to1.22240131
68MP0004510_myositis1.21650651
69MP0003186_abnormal_redox_activity1.20584386
70MP0008007_abnormal_cellular_replicative1.16409732
71* MP0002019_abnormal_tumor_incidence1.16330427
72MP0003866_abnormal_defecation1.15662999
73MP0004147_increased_porphyrin_level1.14574351
74MP0008057_abnormal_DNA_replication1.08811364
75MP0005084_abnormal_gallbladder_morpholo1.07892495
76MP0008058_abnormal_DNA_repair1.06310499
77MP0004957_abnormal_blastocyst_morpholog1.03297666
78MP0002877_abnormal_melanocyte_morpholog1.01978795
79MP0005310_abnormal_salivary_gland1.00384888
80MP0002254_reproductive_system_inflammat0.99977934
81MP0006036_abnormal_mitochondrial_physio0.98864511
82MP0010352_gastrointestinal_tract_polyps0.98659896
83MP0003111_abnormal_nucleus_morphology0.98558200
84MP0000372_irregular_coat_pigmentation0.97253491
85MP0003300_gastrointestinal_ulcer0.96292221
86MP0009278_abnormal_bone_marrow0.94773652
87MP0005083_abnormal_biliary_tract0.93825221
88MP0003448_altered_tumor_morphology0.90795132
89MP0003075_altered_response_to0.89479999
90MP0005023_abnormal_wound_healing0.87599235
91MP0003566_abnormal_cell_adhesion0.87398476
92MP0003136_yellow_coat_color0.84654625
93MP0000313_abnormal_cell_death0.84433361
94MP0004883_abnormal_blood_vessel0.83996900
95MP0000371_diluted_coat_color0.83551780
96MP0001851_eye_inflammation0.81088584
97MP0003191_abnormal_cellular_cholesterol0.79960636
98MP0005390_skeleton_phenotype0.78485120
99MP0001542_abnormal_bone_strength0.77722176
100MP0005319_abnormal_enzyme/_coenzyme0.76481801
101MP0005408_hypopigmentation0.76050447
102MP0003718_maternal_effect0.74526182
103MP0008873_increased_physiological_sensi0.73984580
104MP0008004_abnormal_stomach_pH0.73370238
105MP0002998_abnormal_bone_remodeling0.73040336
106MP0009763_increased_sensitivity_to0.71976502
107MP0001663_abnormal_digestive_system0.69269444
108MP0006035_abnormal_mitochondrial_morpho0.69195039
109MP0003172_abnormal_lysosome_physiology0.68725937
110MP0005164_abnormal_response_to0.66539316
111MP0001986_abnormal_taste_sensitivity0.65461851
112MP0003646_muscle_fatigue0.65068542
113MP0003795_abnormal_bone_structure0.64666500
114MP0008877_abnormal_DNA_methylation0.64197000
115MP0009931_abnormal_skin_appearance0.63079898
116MP0003828_pulmonary_edema0.62616532
117MP0009765_abnormal_xenobiotic_induced0.62280710
118MP0003786_premature_aging0.62215568
119MP0010307_abnormal_tumor_latency0.61411672
120MP0001915_intracranial_hemorrhage0.60792787
121MP0002138_abnormal_hepatobiliary_system0.60752346
122MP0003183_abnormal_peptide_metabolism0.60516397
123MP0004782_abnormal_surfactant_physiolog0.60103914
124MP0003943_abnormal_hepatobiliary_system0.58783451
125MP0000249_abnormal_blood_vessel0.58600536

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.40882287
2Recurrent bacterial skin infections (HP:0005406)4.78561675
3Eczematoid dermatitis (HP:0000976)4.26985631
4Thrombocytosis (HP:0001894)4.23236424
5Elevated erythrocyte sedimentation rate (HP:0003565)4.18095398
6Myositis (HP:0100614)3.94655689
7IgM deficiency (HP:0002850)3.91717736
8Petechiae (HP:0000967)3.89694576
9Chronic otitis media (HP:0000389)3.46095946
10Aplastic anemia (HP:0001915)3.39374143
11Cellulitis (HP:0100658)3.33988077
12Mediastinal lymphadenopathy (HP:0100721)3.24460087
13Abnormality of macrophages (HP:0004311)3.24430352
14Recurrent skin infections (HP:0001581)3.18809687
15Pustule (HP:0200039)3.14617616
16Recurrent viral infections (HP:0004429)3.12683072
17Recurrent gram-negative bacterial infections (HP:0005420)3.11127577
18Abnormality of cells of the erythroid lineage (HP:0012130)3.09955681
19Recurrent bronchitis (HP:0002837)3.09161091
20Abnormal number of erythroid precursors (HP:0012131)3.09150288
21Recurrent fungal infections (HP:0002841)3.08118751
22Increased IgM level (HP:0003496)3.03900890
23Reticulocytopenia (HP:0001896)3.03200155
24Abnormality of B cell number (HP:0010975)3.00868072
25Severe combined immunodeficiency (HP:0004430)2.94282765
26Meningitis (HP:0001287)2.93231810
27Dynein arm defect of respiratory motile cilia (HP:0012255)2.92139935
28Absent/shortened dynein arms (HP:0200106)2.92139935
29Abnormality of T cell physiology (HP:0011840)2.88064343
30Obstructive lung disease (HP:0006536)2.87973357
31Chronic obstructive pulmonary disease (HP:0006510)2.87973357
32Prolonged bleeding time (HP:0003010)2.86825923
33Vacuolated lymphocytes (HP:0001922)2.83041526
34Reduced antithrombin III activity (HP:0001976)2.77793582
35Nasal polyposis (HP:0100582)2.77357913
36Orchitis (HP:0100796)2.74357719
37Abnormality of T cell number (HP:0011839)2.66307840
38Abnormal respiratory motile cilium morphology (HP:0005938)2.65557577
39Abnormal respiratory epithelium morphology (HP:0012253)2.65557577
40Interstitial pulmonary disease (HP:0006530)2.65314320
41Abnormality of the nasal mucosa (HP:0000433)2.63833357
42Combined immunodeficiency (HP:0005387)2.57697219
43Autoimmune thrombocytopenia (HP:0001973)2.55880846
44Vasculitis (HP:0002633)2.55545419
45Agammaglobulinemia (HP:0004432)2.52251458
46T lymphocytopenia (HP:0005403)2.51628719
47Abnormal respiratory motile cilium physiology (HP:0012261)2.50402058
48Abnormal delayed hypersensitivity skin test (HP:0002963)2.50385735
49Urticaria (HP:0001025)2.49969055
50Increased IgE level (HP:0003212)2.48676461
51B lymphocytopenia (HP:0010976)2.48651064
52Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.48211824
53Retrobulbar optic neuritis (HP:0100654)2.46480152
54Optic neuritis (HP:0100653)2.46480152
55Periodontitis (HP:0000704)2.45643252
56Inflammation of the large intestine (HP:0002037)2.45043198
57Gingivitis (HP:0000230)2.44591640
58Epistaxis (HP:0000421)2.44382510
59Abnormality of T cells (HP:0002843)2.44184536
60Gastrointestinal inflammation (HP:0004386)2.42113179
61Gastrointestinal infarctions (HP:0005244)2.41932534
62Abnormal ciliary motility (HP:0012262)2.41921801
63Autoimmune hemolytic anemia (HP:0001890)2.41414088
64Hepatosplenomegaly (HP:0001433)2.40195876
65Recurrent sinusitis (HP:0011108)2.39141283
66Purpura (HP:0000979)2.38553118
6711 pairs of ribs (HP:0000878)2.37885139
68Absent rod-and cone-mediated responses on ERG (HP:0007688)2.37286205
69Poikiloderma (HP:0001029)2.35868091
70Pallor (HP:0000980)2.34075770
71Lymphopenia (HP:0001888)2.33924860
72Abnormality of cells of the lymphoid lineage (HP:0012140)2.33183630
73Chronic mucocutaneous candidiasis (HP:0002728)2.33030218
74Recurrent cutaneous fungal infections (HP:0011370)2.33030218
75Type I transferrin isoform profile (HP:0003642)2.32192910
76Stomatitis (HP:0010280)2.30803939
77Keratoconjunctivitis (HP:0001096)2.29944380
78Entropion (HP:0000621)2.29193406
79Abnormal platelet volume (HP:0011876)2.26405055
80Loss of speech (HP:0002371)2.26213970
81Skin ulcer (HP:0200042)2.22123104
82Hypergammaglobulinemia (HP:0010702)2.20510948
83Hypochromic microcytic anemia (HP:0004840)2.20074130
84Panhypogammaglobulinemia (HP:0003139)2.19856812
85Spontaneous hematomas (HP:0007420)2.19448877
86Osteomyelitis (HP:0002754)2.13372973
87Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.12321634
88Bronchiectasis (HP:0002110)2.11516354
89Abnormality of liposaccharide metabolism (HP:0010968)2.10614741
90Abnormality of glycosphingolipid metabolism (HP:0004343)2.10614741
91Abnormality of glycolipid metabolism (HP:0010969)2.10614741
92Gingival bleeding (HP:0000225)2.10226982
93Increased cerebral lipofuscin (HP:0011813)2.10090736
94Abnormality of the heme biosynthetic pathway (HP:0010472)2.09797840
95Abnormal platelet function (HP:0011869)2.09718342
96Impaired platelet aggregation (HP:0003540)2.09718342
97Leukocytosis (HP:0001974)2.08387825
98Recurrent pneumonia (HP:0006532)2.07433906
99Hypochromic anemia (HP:0001931)2.03826567
100Abnormal protein glycosylation (HP:0012346)2.03148107
101Abnormal glycosylation (HP:0012345)2.03148107
102Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.03148107
103Abnormal protein N-linked glycosylation (HP:0012347)2.03148107
104Mitochondrial inheritance (HP:0001427)2.02247050
105Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.01295278
106Recurrent lower respiratory tract infections (HP:0002783)2.01107172
107Rhinitis (HP:0012384)2.00754001
108Pulmonary fibrosis (HP:0002206)2.00500678
109Erythema (HP:0010783)2.00452711
110Microvesicular hepatic steatosis (HP:0001414)2.00040326
111Hepatocellular necrosis (HP:0001404)1.99447533
112Prostate neoplasm (HP:0100787)1.98604507
113Stomach cancer (HP:0012126)1.98489103
114Anorexia (HP:0002039)1.97480989
115Polyneuropathy (HP:0001271)1.97308535
116Chronic sinusitis (HP:0011109)1.97117064
117Colitis (HP:0002583)1.97083961
118Increased neuronal autofluorescent lipopigment (HP:0002074)1.96661911
119Abnormality of the prostate (HP:0008775)1.96190614
120Encephalitis (HP:0002383)1.95333311
121Granulocytopenia (HP:0001913)1.94909587
122Neutropenia (HP:0001875)1.94818109
123Microcytic anemia (HP:0001935)1.94031078
124Abnormal rod and cone electroretinograms (HP:0008323)1.93972013
125Albinism (HP:0001022)1.93344505
126Episodic fever (HP:0001954)1.92618781
127Hemoptysis (HP:0002105)1.92505952
128Skin rash (HP:0000988)1.91327638
129Basal ganglia calcification (HP:0002135)1.90255901
130Pulmonary infiltrates (HP:0002113)1.90240281
131Sepsis (HP:0100806)1.90155958
132Keratoconjunctivitis sicca (HP:0001097)1.88666501
133Lymphoma (HP:0002665)1.87760691
134IgG deficiency (HP:0004315)1.87613045
135Gastrointestinal stroma tumor (HP:0100723)1.87491396
136Thyroiditis (HP:0100646)1.87350275
137Birth length less than 3rd percentile (HP:0003561)1.87236011
138Eosinophilia (HP:0001880)1.87096529
139Verrucae (HP:0200043)1.86287345
140Papilloma (HP:0012740)1.86287345
141Acute myeloid leukemia (HP:0004808)1.86150710
142Thoracic kyphosis (HP:0002942)1.85752604
143Abnormality of eosinophils (HP:0001879)1.85058265
144Abnormality of iron homeostasis (HP:0011031)1.83296039

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.54095587
2KIT3.32955088
3BTK2.62811561
4JAK32.61200488
5NME22.46448370
6IRAK42.45303754
7VRK22.41240835
8TYK22.25357768
9TEC2.22873988
10BLK2.09917314
11TBK12.09652577
12TXK1.99178349
13TGFBR11.95537850
14SIK31.95322270
15PIM21.91526541
16IKBKE1.81391904
17BCKDK1.79634130
18FLT31.74121433
19ZAP701.67157825
20SYK1.67067526
21CSF1R1.65820711
22MAP3K121.58758908
23TNK21.57396132
24ACVR1B1.53132811
25EIF2AK11.52303876
26TAOK31.48253586
27STK101.45172112
28MAP3K141.42660970
29KDR1.38165247
30LRRK21.37059847
31MARK31.35499467
32EEF2K1.34543781
33IRAK31.34424867
34IKBKB1.34118476
35MUSK1.33772068
36TAOK21.33638468
37LYN1.32691450
38ERN11.32420263
39RPS6KA41.31187815
40PIM11.30576376
41NUAK11.28282697
42MAP2K31.24811302
43MATK1.24302499
44BRSK21.23651100
45BMPR1B1.20170253
46SCYL21.14043001
47LCK1.13870419
48TGFBR21.10351372
49PKN21.10296723
50MAP3K101.07220026
51GRK71.05849484
52TRIM281.05426524
53TRPM71.03461651
54WEE11.00242252
55TAOK10.99748448
56JAK10.99746617
57MAP3K110.98808065
58BUB10.98659351
59IRAK10.95820512
60PDK20.95204999
61TLK10.92839224
62GRK60.92092430
63MAP4K20.90668284
64HCK0.90174567
65FGR0.89881692
66PAK40.89356684
67CCNB10.89326748
68NEK90.89323460
69CSK0.88780653
70STK160.88477361
71MAPK150.88459289
72ITK0.88276902
73FGFR40.84573290
74MAPKAPK30.83537354
75VRK10.83108056
76CLK10.82789310
77CHUK0.81965259
78TESK20.81519803
79FES0.81270971
80RPS6KB20.81262339
81STK240.80787303
82EIF2AK30.80662320
83NLK0.79637231
84ZAK0.78490748
85INSRR0.76498768
86TRIB30.75759630
87CDK80.75369496
88PRKCQ0.75057390
89NEK20.74427233
90PTK2B0.72125982
91JAK20.70588195
92MAP3K80.69763451
93MST40.69591208
94DYRK30.69282008
95CDC70.68940581
96TESK10.67997374
97CDK70.67741662
98ADRBK20.65067255
99ILK0.64830276
100TIE10.63782779
101PASK0.62259834
102MST1R0.60887978
103PIK3CG0.60335184
104ATR0.59731877
105BMPR20.58264591
106RPS6KA60.56443598
107MAP2K20.56254114
108RAF10.55759922
109MAPKAPK20.54870441
110PRPF4B0.54700937
111MAP3K30.54184603
112LIMK10.52088681
113AURKB0.51949283
114STK40.51325647
115RIPK40.50565415
116RPS6KL10.47699510
117RPS6KC10.47699510
118ABL10.46122784
119SRPK10.45542151
120PRKG20.45024693
121MAPK40.44518908
122PAK10.43578401
123EPHB10.41431861
124PRKCD0.40832275
125MAP3K130.40633733
126ABL20.40066813
127RPS6KA50.40027611
128CDK40.38397187
129EIF2AK20.38298216
130IRAK20.38054510
131NME10.37627775
132DAPK10.37367479
133MAP3K10.34669292
134MAP3K50.34213232
135GRK10.30763157
136ADRBK10.29087143
137MAPK70.28835452
138PRKCI0.28757275

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.11263398
2DNA replication_Homo sapiens_hsa030302.92256835
3Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.40768346
4Leishmaniasis_Homo sapiens_hsa051402.30837383
5Primary immunodeficiency_Homo sapiens_hsa053402.26980323
6Caffeine metabolism_Homo sapiens_hsa002322.12828750
7Base excision repair_Homo sapiens_hsa034102.09127889
8Proteasome_Homo sapiens_hsa030502.08565187
9Type I diabetes mellitus_Homo sapiens_hsa049402.04260561
10Measles_Homo sapiens_hsa051621.93603975
11Mismatch repair_Homo sapiens_hsa034301.90481977
12NF-kappa B signaling pathway_Homo sapiens_hsa040641.86440526
13Other glycan degradation_Homo sapiens_hsa005111.77208786
14B cell receptor signaling pathway_Homo sapiens_hsa046621.74705430
15Antigen processing and presentation_Homo sapiens_hsa046121.73898779
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.73513644
17Intestinal immune network for IgA production_Homo sapiens_hsa046721.73481728
18Herpes simplex infection_Homo sapiens_hsa051681.72406631
19Hematopoietic cell lineage_Homo sapiens_hsa046401.68469599
20Legionellosis_Homo sapiens_hsa051341.65791041
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.59481578
22Non-homologous end-joining_Homo sapiens_hsa034501.58947687
23RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.56167757
24Homologous recombination_Homo sapiens_hsa034401.53843556
25Toll-like receptor signaling pathway_Homo sapiens_hsa046201.52554218
26RNA polymerase_Homo sapiens_hsa030201.48962618
27Osteoclast differentiation_Homo sapiens_hsa043801.45950814
28Shigellosis_Homo sapiens_hsa051311.43290539
29Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.40467503
30Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.39829692
31Glycosaminoglycan degradation_Homo sapiens_hsa005311.39514150
32Allograft rejection_Homo sapiens_hsa053301.38622704
33Malaria_Homo sapiens_hsa051441.35782062
34Spliceosome_Homo sapiens_hsa030401.35731644
35Jak-STAT signaling pathway_Homo sapiens_hsa046301.33487632
36Pyrimidine metabolism_Homo sapiens_hsa002401.30711295
37Protein export_Homo sapiens_hsa030601.28425547
38Pertussis_Homo sapiens_hsa051331.27065334
39Apoptosis_Homo sapiens_hsa042101.23661739
40Influenza A_Homo sapiens_hsa051641.23158036
41Nucleotide excision repair_Homo sapiens_hsa034201.23038227
42Oxidative phosphorylation_Homo sapiens_hsa001901.21311594
43p53 signaling pathway_Homo sapiens_hsa041151.21194769
44Cell cycle_Homo sapiens_hsa041101.17323920
45Parkinsons disease_Homo sapiens_hsa050121.16036365
46Hepatitis B_Homo sapiens_hsa051611.15075681
47Tuberculosis_Homo sapiens_hsa051521.13028859
48Graft-versus-host disease_Homo sapiens_hsa053321.12328506
49Toxoplasmosis_Homo sapiens_hsa051451.10507021
50NOD-like receptor signaling pathway_Homo sapiens_hsa046211.09826762
51Acute myeloid leukemia_Homo sapiens_hsa052211.07813654
52Asthma_Homo sapiens_hsa053101.06464879
53Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.05271190
54RNA degradation_Homo sapiens_hsa030181.03553530
55Staphylococcus aureus infection_Homo sapiens_hsa051501.02594622
56Leukocyte transendothelial migration_Homo sapiens_hsa046701.01071093
57Epstein-Barr virus infection_Homo sapiens_hsa051691.00760827
58Transcriptional misregulation in cancer_Homo sapiens_hsa052020.96913552
59Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.95512388
60Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.93654161
61TNF signaling pathway_Homo sapiens_hsa046680.93012704
62Salmonella infection_Homo sapiens_hsa051320.93008454
63African trypanosomiasis_Homo sapiens_hsa051430.90356138
64Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.89070328
65Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.88688524
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.88185043
67Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.87946983
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.87423458
69Basal transcription factors_Homo sapiens_hsa030220.85928977
70Pentose phosphate pathway_Homo sapiens_hsa000300.84511974
71Viral carcinogenesis_Homo sapiens_hsa052030.83127618
72Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.82151523
73Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.81408312
74Platelet activation_Homo sapiens_hsa046110.81078660
75Huntingtons disease_Homo sapiens_hsa050160.80899540
76Fanconi anemia pathway_Homo sapiens_hsa034600.79711176
77T cell receptor signaling pathway_Homo sapiens_hsa046600.79100963
78RNA transport_Homo sapiens_hsa030130.77500983
79Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.77425454
80Regulation of autophagy_Homo sapiens_hsa041400.76857174
81Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.76741085
82Lysosome_Homo sapiens_hsa041420.75197743
83N-Glycan biosynthesis_Homo sapiens_hsa005100.73103537
84Collecting duct acid secretion_Homo sapiens_hsa049660.72544512
85Viral myocarditis_Homo sapiens_hsa054160.71357966
86Systemic lupus erythematosus_Homo sapiens_hsa053220.70755158
87Hepatitis C_Homo sapiens_hsa051600.68201237
88Chronic myeloid leukemia_Homo sapiens_hsa052200.65986056
89Phagosome_Homo sapiens_hsa041450.65859041
90Chemokine signaling pathway_Homo sapiens_hsa040620.65705660
91HTLV-I infection_Homo sapiens_hsa051660.65306707
92Pancreatic cancer_Homo sapiens_hsa052120.64874155
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.62166499
94Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.61594628
95Thyroid cancer_Homo sapiens_hsa052160.60176322
96Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.59749827
97Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59193518
98Arachidonic acid metabolism_Homo sapiens_hsa005900.55448542
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.55069713
100One carbon pool by folate_Homo sapiens_hsa006700.54752757
101AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.54004965
102Small cell lung cancer_Homo sapiens_hsa052220.51967204
103Selenocompound metabolism_Homo sapiens_hsa004500.50191014
104Rheumatoid arthritis_Homo sapiens_hsa053230.50031073
105Purine metabolism_Homo sapiens_hsa002300.49724510
106Autoimmune thyroid disease_Homo sapiens_hsa053200.49550947
107Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.46275280
108Drug metabolism - other enzymes_Homo sapiens_hsa009830.45883608
109Folate biosynthesis_Homo sapiens_hsa007900.43060959
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43039274
111Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42714033
112Galactose metabolism_Homo sapiens_hsa000520.42212177
113Sulfur relay system_Homo sapiens_hsa041220.41974775
114alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.41601687
115Glutathione metabolism_Homo sapiens_hsa004800.41294596
116Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41046593
117Prolactin signaling pathway_Homo sapiens_hsa049170.40168323
118Non-small cell lung cancer_Homo sapiens_hsa052230.39478311
119Endocytosis_Homo sapiens_hsa041440.31378516
120Peroxisome_Homo sapiens_hsa041460.31240319
121Alzheimers disease_Homo sapiens_hsa050100.30452398

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