BICC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an RNA-binding protein that is active in regulating gene expression by modulating protein translation during embryonic development. Mouse studies identified the corresponding protein to be under strict control during cell differentiation and to be a maternally provided gene product. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tooth mineralization (GO:0034505)6.14022830
2collagen fibril organization (GO:0030199)5.94085253
3protein heterotrimerization (GO:0070208)5.90295757
4detection of chemical stimulus involved in sensory perception of smell (GO:0050911)5.74463777
5chondrocyte proliferation (GO:0035988)5.26632812
6bone trabecula formation (GO:0060346)5.11183589
7protein K11-linked deubiquitination (GO:0035871)4.87362403
8cellular response to vitamin D (GO:0071305)4.80257663
9cellular response to vitamin (GO:0071295)4.77935340
10ovulation cycle (GO:0042698)4.62525316
11metanephric mesenchyme development (GO:0072075)4.38421691
12sequestering of extracellular ligand from receptor (GO:0035581)4.37826672
13retina layer formation (GO:0010842)4.34833582
14skin morphogenesis (GO:0043589)4.34676762
15negative regulation of T-helper cell differentiation (GO:0045623)4.34592895
16negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)4.34592895
17cellular response to exogenous dsRNA (GO:0071360)4.15727919
18metanephric nephron epithelium development (GO:0072243)4.10085473
19kidney mesenchyme development (GO:0072074)4.05526499
20metanephric nephron tubule development (GO:0072234)4.05141765
21metanephric tubule development (GO:0072170)4.05141765
22collagen metabolic process (GO:0032963)4.04027742
23regulation of T-helper 1 cell differentiation (GO:0045625)3.99875144
24collagen catabolic process (GO:0030574)3.99846389
25endodermal cell differentiation (GO:0035987)3.91550650
26cell adhesion mediated by integrin (GO:0033627)3.89192145
27metanephric epithelium development (GO:0072207)3.86308807
28regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.80771988
29detection of chemical stimulus involved in sensory perception (GO:0050907)3.80522566
30multicellular organismal macromolecule metabolic process (GO:0044259)3.79979540
31epithelial cell-cell adhesion (GO:0090136)3.79252845
32axon extension involved in axon guidance (GO:0048846)3.78486145
33neuron projection extension involved in neuron projection guidance (GO:1902284)3.78486145
34multicellular organismal catabolic process (GO:0044243)3.75463735
35fibroblast migration (GO:0010761)3.70885866
36multicellular organismal metabolic process (GO:0044236)3.67792267
37extracellular matrix disassembly (GO:0022617)3.63269281
38natural killer cell activation involved in immune response (GO:0002323)3.59124809
39positive regulation of protein sumoylation (GO:0033235)3.59099698
40glomerular basement membrane development (GO:0032836)3.57991426
41negative regulation of alpha-beta T cell differentiation (GO:0046639)3.56388681
42keratan sulfate catabolic process (GO:0042340)3.55752670
43positive regulation of osteoblast proliferation (GO:0033690)3.54888012
44seminiferous tubule development (GO:0072520)3.54142705
45icosanoid secretion (GO:0032309)3.49716552
46arachidonic acid secretion (GO:0050482)3.49716552
47regulation of T-helper 2 cell differentiation (GO:0045628)3.49375821
48positive regulation of endothelial cell apoptotic process (GO:2000353)3.46008393
49extracellular fibril organization (GO:0043206)3.43500479
50hippo signaling (GO:0035329)3.39873973
51basement membrane organization (GO:0071711)3.36816162
52positive regulation of SMAD protein import into nucleus (GO:0060391)3.35746617
53mesenchymal-epithelial cell signaling (GO:0060638)3.35739672
54anatomical structure regression (GO:0060033)3.35087821
55retina vasculature morphogenesis in camera-type eye (GO:0061299)3.34297731
56endothelial cell morphogenesis (GO:0001886)3.29248418
57nephron tubule development (GO:0072080)3.26803352
58negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.26726528
59negative regulation of chondrocyte differentiation (GO:0032331)3.26716895
60righting reflex (GO:0060013)3.24058524
61peptidyl-proline hydroxylation (GO:0019511)3.22256470
62regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.21921104
63regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.18966441
64renal filtration (GO:0097205)3.16833908
65insulin-like growth factor receptor signaling pathway (GO:0048009)3.16803434
66negative regulation of axon extension involved in axon guidance (GO:0048843)3.16708400
67extracellular matrix assembly (GO:0085029)3.13673373
68regulation of hippo signaling (GO:0035330)3.12357806
69enteric nervous system development (GO:0048484)3.12280691
70branching involved in salivary gland morphogenesis (GO:0060445)3.10907816
71fibril organization (GO:0097435)3.09708636
72nephron tubule morphogenesis (GO:0072078)3.08793474
73nephron epithelium morphogenesis (GO:0072088)3.08793474
74planar cell polarity pathway involved in neural tube closure (GO:0090179)3.08706881
75cardiovascular system development (GO:0072358)3.08440571
76regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.07752639
77regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.05010100
78nephron epithelium development (GO:0072009)3.04497394
79apoptotic cell clearance (GO:0043277)3.04072172
80dermatan sulfate biosynthetic process (GO:0030208)3.03420921
81plasma membrane repair (GO:0001778)3.03015865
82mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.02943823
83regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.00885933
84cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.99201223
85substrate-dependent cell migration (GO:0006929)2.97279619
86negative regulation of axon guidance (GO:1902668)2.96251011
87cell migration involved in heart development (GO:0060973)2.96129781
88regulation of type B pancreatic cell apoptotic process (GO:2000674)2.95686497
89embryonic digestive tract morphogenesis (GO:0048557)2.94885684
90positive regulation of actin filament depolymerization (GO:0030836)2.94421719
91muscle organ morphogenesis (GO:0048644)2.94241994
92extracellular matrix organization (GO:0030198)2.93901044
93positive regulation of protein autophosphorylation (GO:0031954)2.92813801
94extracellular structure organization (GO:0043062)2.92638473
95pericardium development (GO:0060039)2.91876744
96regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.91392201
97maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.91141919
98positive regulation of RNA splicing (GO:0033120)2.90447290
99vascular endothelial growth factor signaling pathway (GO:0038084)2.89939293
100regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.88979233
101renal tubule development (GO:0061326)2.88265362
102chondrocyte development (GO:0002063)2.88103252
103regulation of integrin-mediated signaling pathway (GO:2001044)2.87843631
104wound healing, spreading of epidermal cells (GO:0035313)2.86678094
105regulation of interleukin-8 secretion (GO:2000482)2.86223155
106pattern specification involved in kidney development (GO:0061004)2.85392511
107regulation of apoptotic process involved in morphogenesis (GO:1902337)2.83951673
108cellular response to nutrient (GO:0031670)2.82846519
109regulation of tight junction assembly (GO:2000810)2.82818115
110regulation of organ formation (GO:0003156)2.82149249
111protein localization to cell surface (GO:0034394)2.80949390
112regulation of SMAD protein import into nucleus (GO:0060390)2.80070028
113cell proliferation involved in metanephros development (GO:0072203)2.79175788
114nephron tubule formation (GO:0072079)2.79158956
115organ induction (GO:0001759)2.79046709
116trabecula formation (GO:0060343)2.78857056
117endocardial cushion development (GO:0003197)2.78691051
118positive regulation of mitochondrial fission (GO:0090141)2.78347548
119protein retention in ER lumen (GO:0006621)2.78008772
120angiogenesis involved in wound healing (GO:0060055)2.77761528
121fructose metabolic process (GO:0006000)2.77303010
122positive regulation of T-helper 1 type immune response (GO:0002827)2.76712616
123virion attachment to host cell (GO:0019062)2.76644886
124adhesion of symbiont to host cell (GO:0044650)2.76644886
125mesodermal cell differentiation (GO:0048333)2.76272306
126icosanoid transport (GO:0071715)2.75526126
127fatty acid derivative transport (GO:1901571)2.75526126
128collecting duct development (GO:0072044)2.74560459
129smooth muscle tissue development (GO:0048745)2.74321368
130craniofacial suture morphogenesis (GO:0097094)2.73716505
131protein hydroxylation (GO:0018126)2.73369547
132negative regulation of cartilage development (GO:0061037)2.73215213
133detection of chemical stimulus (GO:0009593)2.71347608
134negative regulation of type 2 immune response (GO:0002829)2.70146673
135drug transmembrane transport (GO:0006855)2.69598384
136peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.69082303
137stress fiber assembly (GO:0043149)2.68759867
138dendritic spine morphogenesis (GO:0060997)2.67630708
139cell migration involved in sprouting angiogenesis (GO:0002042)2.67598939
140dermatan sulfate metabolic process (GO:0030205)2.67217864
141exocrine pancreas development (GO:0031017)2.65394846
142regulation of metanephros development (GO:0072215)2.65051594
143glomerular filtration (GO:0003094)2.63529156
144mesenchyme development (GO:0060485)2.63498535
145positive regulation of cartilage development (GO:0061036)2.63465779
146response to redox state (GO:0051775)2.63439915
147positive regulation of protein targeting to membrane (GO:0090314)2.63357508
148positive regulation of mesenchymal cell proliferation (GO:0002053)2.63192990
149positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.62862280
150negative regulation of fatty acid transport (GO:2000192)2.62794718
151negative regulation of catenin import into nucleus (GO:0035414)2.62184158
152muscle cell migration (GO:0014812)2.61281603
153renal tubule morphogenesis (GO:0061333)2.60916703
154COPI coating of Golgi vesicle (GO:0048205)2.60603874
155Golgi transport vesicle coating (GO:0048200)2.60603874
156cAMP biosynthetic process (GO:0006171)2.59862448
157extracellular negative regulation of signal transduction (GO:1900116)2.59146218
158extracellular regulation of signal transduction (GO:1900115)2.59146218
159positive regulation of fibroblast migration (GO:0010763)2.59124500
160phosphatidylinositol acyl-chain remodeling (GO:0036149)2.59024372
161anterior/posterior axis specification, embryo (GO:0008595)2.57609933
162positive regulation of smoothened signaling pathway (GO:0045880)2.56297027
163digestive tract morphogenesis (GO:0048546)2.55241426
164vagina development (GO:0060068)2.53052062
165hyaluronan catabolic process (GO:0030214)2.53025096
166regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.52483422
167activation of protein kinase A activity (GO:0034199)2.51598397
168branching involved in prostate gland morphogenesis (GO:0060442)2.50976546
169positive regulation of extracellular matrix organization (GO:1903055)2.50133543
170heterotypic cell-cell adhesion (GO:0034113)2.50111075
171embryonic forelimb morphogenesis (GO:0035115)2.48779807
172negative regulation of mast cell activation (GO:0033004)2.47023163
173negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.46343273
174positive regulation of natural killer cell differentiation (GO:0032825)2.45996293
175proximal/distal pattern formation (GO:0009954)2.45205244
176diterpenoid biosynthetic process (GO:0016102)2.43588123
177mesenchymal cell proliferation (GO:0010463)2.40820774
178cellular response to interferon-alpha (GO:0035457)2.40221928
179xenobiotic catabolic process (GO:0042178)2.39162696
180regulation of mesenchymal cell apoptotic process (GO:2001053)2.37763784
181regulation of helicase activity (GO:0051095)2.37281125
182regulation of extracellular matrix disassembly (GO:0010715)2.35343308
183retinal metabolic process (GO:0042574)2.34171364
184middle ear morphogenesis (GO:0042474)2.34039363
185membrane raft organization (GO:0031579)2.31440661
186arginine catabolic process (GO:0006527)2.31326622

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human6.19388295
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse5.01337569
3RARG_19884340_ChIP-ChIP_MEFs_Mouse4.65076634
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.83017783
5PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.52673914
6SMAD_19615063_ChIP-ChIP_OVARY_Human3.17208455
7CLOCK_20551151_ChIP-Seq_293T_Human3.07781119
8EP300_21415370_ChIP-Seq_HL-1_Mouse2.92332861
9* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.83774868
10WT1_19549856_ChIP-ChIP_CCG9911_Human2.67230070
11ESR1_21235772_ChIP-Seq_MCF-7_Human2.63956079
12* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.63878426
13* GBX2_23144817_ChIP-Seq_PC3_Human2.60947459
14* CJUN_26792858_Chip-Seq_BT549_Human2.58083067
15* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.55448389
16RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.52224245
17VDR_22108803_ChIP-Seq_LS180_Human2.47620452
18TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.43037990
19ZFP57_27257070_Chip-Seq_ESCs_Mouse2.36810180
20CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.30001771
21AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.13310690
22CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.12661058
23NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.12238302
24NRF2_20460467_ChIP-Seq_MEFs_Mouse2.12238302
25SALL1_21062744_ChIP-ChIP_HESCs_Human2.03288136
26SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.02291521
27PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.99662357
28EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.96785146
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.96343881
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.95683519
31BRD4_25478319_ChIP-Seq_HGPS_Human1.95572250
32ESR2_21235772_ChIP-Seq_MCF-7_Human1.94478520
33* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.94270696
34WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.92867383
35CDX2_19796622_ChIP-Seq_MESCs_Mouse1.92546351
36* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.86120123
37POU3F2_20337985_ChIP-ChIP_501MEL_Human1.76859548
38ZNF217_24962896_ChIP-Seq_MCF-7_Human1.66366405
39ESR1_20079471_ChIP-ChIP_T-47D_Human1.64024788
40P300_19829295_ChIP-Seq_ESCs_Human1.61407128
41FUS_26573619_Chip-Seq_HEK293_Human1.60991191
42SOX2_20726797_ChIP-Seq_SW620_Human1.59419976
43* SMAD4_21799915_ChIP-Seq_A2780_Human1.59181281
44SALL4_18804426_ChIP-ChIP_XEN_Mouse1.57864885
45HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.57119750
46SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.57064873
47SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.57064873
48TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.56074992
49ZNF274_21170338_ChIP-Seq_K562_Hela1.55826122
50TBX20_22080862_ChIP-Seq_HEART_Mouse1.54767325
51TBX20_22328084_ChIP-Seq_HEART_Mouse1.54767325
52NANOG_18555785_Chip-Seq_ESCs_Mouse1.54130966
53TP53_18474530_ChIP-ChIP_U2OS_Human1.53081082
54RBPJ_22232070_ChIP-Seq_NCS_Mouse1.52551468
55EED_16625203_ChIP-ChIP_MESCs_Mouse1.52501245
56BMI1_23680149_ChIP-Seq_NPCS_Mouse1.52461431
57* FOXO3_23340844_ChIP-Seq_DLD1_Human1.49504300
58SOX9_24532713_ChIP-Seq_HFSC_Mouse1.49218996
59SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46434494
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.46188935
61TP53_16413492_ChIP-PET_HCT116_Human1.45831148
62* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.45427208
63MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.42844049
64CTBP2_25329375_ChIP-Seq_LNCAP_Human1.41948769
65FLI1_27457419_Chip-Seq_LIVER_Mouse1.41862807
66TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.41632396
67IGF1R_20145208_ChIP-Seq_DFB_Human1.41569398
68TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38012882
69HIF1A_21447827_ChIP-Seq_MCF-7_Human1.37847426
70JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.37717096
71FOXM1_26456572_ChIP-Seq_MCF-7_Human1.37093774
72SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.36886668
73EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.36586315
74RNF2_27304074_Chip-Seq_NSC_Mouse1.36050515
75FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.35000793
76ER_23166858_ChIP-Seq_MCF-7_Human1.34405043
77AR_21572438_ChIP-Seq_LNCaP_Human1.33760429
78* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.31822302
79SUZ12_27294783_Chip-Seq_NPCs_Mouse1.31360486
80* EZH2_27294783_Chip-Seq_NPCs_Mouse1.30895980
81PCGF2_27294783_Chip-Seq_ESCs_Mouse1.30838508
82GATA2_21666600_ChIP-Seq_HMVEC_Human1.30334149
83AR_25329375_ChIP-Seq_VCAP_Human1.29956638
84MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29440128
85IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28553248
86CBP_20019798_ChIP-Seq_JUKART_Human1.28553248
87JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.27787232
88ISL1_27105846_Chip-Seq_CPCs_Mouse1.26926448
89* STAT3_23295773_ChIP-Seq_U87_Human1.26445195
90* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.24549886
91* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.24549886
92CTBP1_25329375_ChIP-Seq_LNCAP_Human1.23599051
93NFIB_24661679_ChIP-Seq_LUNG_Mouse1.22860143
94JARID2_20075857_ChIP-Seq_MESCs_Mouse1.22532469
95OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22076829
96* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21971844
97TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.20748369
98CBX2_27304074_Chip-Seq_ESCs_Mouse1.20711376
99E2F1_18555785_Chip-Seq_ESCs_Mouse1.20556627
100EWS_26573619_Chip-Seq_HEK293_Human1.20297772
101POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19579203
102TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19579203
103* UBF1/2_26484160_Chip-Seq_HMECs_Human1.19134438
104ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.18582563
105SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.18529812
106* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.17695165
107TP53_20018659_ChIP-ChIP_R1E_Mouse1.17094220
108* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.16128147
109* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.16020534
110BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.15861882
111SUZ12_18555785_Chip-Seq_ESCs_Mouse1.15686090
112CMYC_18555785_Chip-Seq_ESCs_Mouse1.15582360
113ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.14946799
114BCAT_22108803_ChIP-Seq_LS180_Human1.14937229
115SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.14793207
116STAT3_18555785_Chip-Seq_ESCs_Mouse1.14545016
117* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.13926073
118NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.13158474
119KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.12875532
120* PIAS1_25552417_ChIP-Seq_VCAP_Human1.12184867
121EZH2_27304074_Chip-Seq_ESCs_Mouse1.12030184
122CDX2_22108803_ChIP-Seq_LS180_Human1.11954902
123P53_22387025_ChIP-Seq_ESCs_Mouse1.11050306
124NFE2_27457419_Chip-Seq_LIVER_Mouse1.10637438
125EGR1_23403033_ChIP-Seq_LIVER_Mouse1.10269978
126PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.09979711
127SOX2_18555785_Chip-Seq_ESCs_Mouse1.09146350
128* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.09137861
129NR3C1_23031785_ChIP-Seq_PC12_Mouse1.08830044
130TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08502253
131DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.08173528
132ATF3_27146783_Chip-Seq_COLON_Human1.08080896
133SMAD4_21741376_ChIP-Seq_EPCs_Human1.07871237
134TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06809305
135TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.06218289
136* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.05274675
137* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.04809723
138TCF4_22108803_ChIP-Seq_LS180_Human1.04276562
139RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.03907115
140TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03846251
141* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03803049
142NANOG_19829295_ChIP-Seq_ESCs_Human1.03350333
143CDX2_20551321_ChIP-Seq_CACO-2_Human1.03189233
144ELK3_25401928_ChIP-Seq_HUVEC_Human1.02712086
145PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.02686355
146TP53_23651856_ChIP-Seq_MEFs_Mouse1.02521199
147TP63_23658742_ChIP-Seq_EP156T_Human1.01945583
148LXR_22158963_ChIP-Seq_LIVER_Mouse1.00706974
149NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.99608257
150RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.99590218
151ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.99350943
152AHR_22903824_ChIP-Seq_MCF-7_Human0.99182391
153PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.98483259
154* FOXA2_19822575_ChIP-Seq_HepG2_Human0.95998829
155ARNT_22903824_ChIP-Seq_MCF-7_Human0.94665039
156* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.94607139
157SMC3_22415368_ChIP-Seq_MEFs_Mouse0.94451946
158FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.93602166
159GATA4_25053715_ChIP-Seq_YYC3_Human0.92831200
160RACK7_27058665_Chip-Seq_MCF-7_Human0.92622264
161P63_26484246_Chip-Seq_KERATINOCYTES_Human0.89917767
162EGR1_19374776_ChIP-ChIP_THP-1_Human0.89201929
163CTNNB1_20460455_ChIP-Seq_HCT116_Human0.88714841
164KLF5_25053715_ChIP-Seq_YYC3_Human0.87253943
165NFI_21473784_ChIP-Seq_ESCs_Mouse0.87053363
166AR_21909140_ChIP-Seq_LNCAP_Human0.86820414

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen7.80834410
2MP0005503_abnormal_tendon_morphology5.56757851
3MP0005275_abnormal_skin_tensile5.18118170
4MP0003950_abnormal_plasma_membrane4.29585301
5MP0001958_emphysema3.66428636
6* MP0005084_abnormal_gallbladder_morpholo3.48081377
7MP0003705_abnormal_hypodermis_morpholog3.42134317
8MP0003279_aneurysm3.17759177
9MP0009384_cardiac_valve_regurgitation2.91901061
10MP0004272_abnormal_basement_membrane2.90470368
11MP0006054_spinal_hemorrhage2.64674209
12MP0005623_abnormal_meninges_morphology2.58410488
13MP0002163_abnormal_gland_morphology2.28733495
14MP0005257_abnormal_intraocular_pressure2.05854573
15MP0002138_abnormal_hepatobiliary_system2.03803674
16MP0005508_abnormal_skeleton_morphology1.98899138
17MP0005187_abnormal_penis_morphology1.90050740
18MP0003300_gastrointestinal_ulcer1.87429344
19MP0002108_abnormal_muscle_morphology1.86634658
20MP0002295_abnormal_pulmonary_circulatio1.82159714
21MP0002139_abnormal_hepatobiliary_system1.81148361
22MP0000372_irregular_coat_pigmentation1.81077463
23MP0002060_abnormal_skin_morphology1.80515499
24MP0005360_urolithiasis1.75121295
25MP0003283_abnormal_digestive_organ1.73310038
26MP0002896_abnormal_bone_mineralization1.72437742
27MP0000013_abnormal_adipose_tissue1.68746977
28MP0008961_abnormal_basal_metabolism1.68220385
29MP0005379_endocrine/exocrine_gland_phen1.66220579
30MP0003566_abnormal_cell_adhesion1.65002980
31MP0002876_abnormal_thyroid_physiology1.62402986
32MP0003385_abnormal_body_wall1.58185915
33MP0009250_abnormal_appendicular_skeleto1.54287700
34MP0005023_abnormal_wound_healing1.41800757
35MP0010030_abnormal_orbit_morphology1.39568460
36MP0000537_abnormal_urethra_morphology1.38663686
37MP0010368_abnormal_lymphatic_system1.37259374
38MP0001299_abnormal_eye_distance/1.36195264
39MP0003115_abnormal_respiratory_system1.33062990
40MP0001542_abnormal_bone_strength1.32032978
41MP0000534_abnormal_ureter_morphology1.31591915
42MP0000631_abnormal_neuroendocrine_gland1.30927417
43MP0003942_abnormal_urinary_system1.26606680
44MP0002168_other_aberrant_phenotype1.26349345
45MP0000163_abnormal_cartilage_morphology1.25794985
46MP0009053_abnormal_anal_canal1.24640999
47MP0003091_abnormal_cell_migration1.24582141
48MP0003941_abnormal_skin_development1.21130285
49MP0002877_abnormal_melanocyte_morpholog1.20735785
50MP0000751_myopathy1.18859978
51MP0000428_abnormal_craniofacial_morphol1.18183351
52MP0002282_abnormal_trachea_morphology1.17672045
53MP0000733_abnormal_muscle_development1.16529090
54MP0002115_abnormal_skeleton_extremities1.16404601
55MP0000767_abnormal_smooth_muscle1.15157008
56MP0006072_abnormal_retinal_apoptosis1.14842245
57MP0005164_abnormal_response_to1.12290992
58MP0005389_reproductive_system_phenotype1.10959495
59MP0001243_abnormal_dermal_layer1.09500171
60MP0003045_fibrosis1.08651564
61MP0002160_abnormal_reproductive_system1.06164436
62MP0000003_abnormal_adipose_tissue1.05928038
63MP0002751_abnormal_autonomic_nervous1.05752745
64* MP0002928_abnormal_bile_duct1.04821522
65MP0010352_gastrointestinal_tract_polyps1.01686414
66MP0005390_skeleton_phenotype1.00500643
67MP0004084_abnormal_cardiac_muscle0.97992707
68MP0002933_joint_inflammation0.97614021
69MP0009780_abnormal_chondrocyte_physiolo0.96972311
70* MP0005220_abnormal_exocrine_pancreas0.96843320
71MP0002932_abnormal_joint_morphology0.96832260
72* MP0003252_abnormal_bile_duct0.96394391
73MP0005332_abnormal_amino_acid0.95971634
74MP0000613_abnormal_salivary_gland0.95702491
75MP0002113_abnormal_skeleton_development0.95235050
76MP0000516_abnormal_urinary_system0.95012334
77MP0005367_renal/urinary_system_phenotyp0.95012334
78MP0003195_calcinosis0.92678016
79MP0001879_abnormal_lymphatic_vessel0.91976585
80MP0003937_abnormal_limbs/digits/tail_de0.90416673
81MP0004484_altered_response_of0.90198465
82MP0000371_diluted_coat_color0.88571695
83MP0002998_abnormal_bone_remodeling0.87907748
84MP0004134_abnormal_chest_morphology0.86939124
85MP0006138_congestive_heart_failure0.86692492
86MP0002132_abnormal_respiratory_system0.86589678
87MP0003935_abnormal_craniofacial_develop0.85247084
88MP0003755_abnormal_palate_morphology0.83108203
89MP0000432_abnormal_head_morphology0.82518199
90MP0004130_abnormal_muscle_cell0.82308727
91MP0001348_abnormal_lacrimal_gland0.82003985
92MP0005171_absent_coat_pigmentation0.81438950
93MP0002133_abnormal_respiratory_system0.80598697
94MP0005388_respiratory_system_phenotype0.80598697
95MP0004185_abnormal_adipocyte_glucose0.80170741
96MP0004883_abnormal_blood_vessel0.79941984
97MP0002837_dystrophic_cardiac_calcinosis0.78512651
98MP0002128_abnormal_blood_circulation0.78282454
99MP0002109_abnormal_limb_morphology0.78156109
100MP0002102_abnormal_ear_morphology0.77006246
101MP0005375_adipose_tissue_phenotype0.76023918
102MP0003795_abnormal_bone_structure0.74715574
103MP0004233_abnormal_muscle_weight0.73727149
104MP0000750_abnormal_muscle_regeneration0.73461895
105MP0002116_abnormal_craniofacial_bone0.73393907
106MP0001177_atelectasis0.73188278
107MP0000639_abnormal_adrenal_gland0.72542989
108MP0002233_abnormal_nose_morphology0.72281326
109MP0000049_abnormal_middle_ear0.72016815
110MP0002090_abnormal_vision0.71956219
111MP0003315_abnormal_perineum_morphology0.71318049
112MP0010386_abnormal_urinary_bladder0.69807445
113MP0000762_abnormal_tongue_morphology0.69791622
114MP0005551_abnormal_eye_electrophysiolog0.69650829
115MP0002697_abnormal_eye_size0.69339561
116MP0005595_abnormal_vascular_smooth0.67089495
117MP0002249_abnormal_larynx_morphology0.66976077
118MP0001756_abnormal_urination0.66542296
119MP0008775_abnormal_heart_ventricle0.66540375
120MP0005165_increased_susceptibility_to0.66146854
121MP0006276_abnormal_autonomic_nervous0.65700783
122MP0000538_abnormal_urinary_bladder0.65592070
123MP0000749_muscle_degeneration0.65566557
124MP0000230_abnormal_systemic_arterial0.65306227
125MP0002111_abnormal_tail_morphology0.65217084
126MP0001614_abnormal_blood_vessel0.64775609
127MP0000462_abnormal_digestive_system0.64687694
128MP0005646_abnormal_pituitary_gland0.64560365
129MP0001175_abnormal_lung_morphology0.63403110
130MP0005395_other_phenotype0.62471617
131MP0002089_abnormal_postnatal_growth/wei0.62338667
132MP0005408_hypopigmentation0.62312317
133MP0003122_maternal_imprinting0.61356787
134MP0004087_abnormal_muscle_fiber0.61195485
135MP0002938_white_spotting0.60440029
136* MP0002135_abnormal_kidney_morphology0.60022518
137MP0005197_abnormal_uvea_morphology0.59832837
138MP0005193_abnormal_anterior_eye0.58407255
139MP0006082_CNS_inflammation0.58108469
140MP0008875_abnormal_xenobiotic_pharmacok0.56744898

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)8.00171879
2Premature rupture of membranes (HP:0001788)7.29238952
3Ankle contracture (HP:0006466)5.19856972
4Alveolar cell carcinoma (HP:0006519)4.83671998
5Aortic dissection (HP:0002647)4.79256493
6Broad metatarsal (HP:0001783)4.73526860
7Soft skin (HP:0000977)4.64858876
8Shallow orbits (HP:0000586)4.46418143
9Neoplasm of the tracheobronchial system (HP:0100552)4.31064357
10Atrophic scars (HP:0001075)4.11124486
11Neonatal short-limb short stature (HP:0008921)3.95052282
12Aortic aneurysm (HP:0004942)3.91555538
13Bladder diverticulum (HP:0000015)3.86170774
14Cervical subluxation (HP:0003308)3.79648149
15Abnormality of dentin (HP:0010299)3.79006149
16Peritonitis (HP:0002586)3.74466678
17Abnormal delayed hypersensitivity skin test (HP:0002963)3.73796264
18Cerebral aneurysm (HP:0004944)3.64644045
19Fragile skin (HP:0001030)3.61435151
20Dilatation of the ascending aorta (HP:0005111)3.52189534
21Follicular hyperkeratosis (HP:0007502)3.45209920
22Mitral valve prolapse (HP:0001634)3.26478737
23Wormian bones (HP:0002645)3.25469300
24Abnormality of the phalanges of the 2nd finger (HP:0009541)3.11106645
25Blue sclerae (HP:0000592)3.10235229
26Microglossia (HP:0000171)3.07304080
27Wrist flexion contracture (HP:0001239)3.04597649
28Spinal rigidity (HP:0003306)3.03769685
29Thin bony cortex (HP:0002753)3.01872594
30Type 1 muscle fiber predominance (HP:0003803)3.00507456
31Vertebral compression fractures (HP:0002953)2.98312002
32Vascular tortuosity (HP:0004948)2.96356989
33Polyuria (HP:0000103)2.90128457
34Hamartoma of the eye (HP:0010568)2.89724065
35Biconcave vertebral bodies (HP:0004586)2.89174946
36Genu recurvatum (HP:0002816)2.87053258
37Increased connective tissue (HP:0009025)2.79705730
38Hyperextensible skin (HP:0000974)2.78398204
39Amelogenesis imperfecta (HP:0000705)2.77707994
40Keratoconus (HP:0000563)2.75523538
41Increased corneal curvature (HP:0100692)2.75523538
42Overgrowth (HP:0001548)2.74893710
43Metaphyseal dysplasia (HP:0100255)2.73749825
44Arterial tortuosity (HP:0005116)2.72675571
45Hydroxyprolinuria (HP:0003080)2.72364588
46Abnormality of proline metabolism (HP:0010907)2.72364588
47Ependymoma (HP:0002888)2.65960517
48Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.61650997
49Abnormality of renal resorption (HP:0011038)2.57366766
50Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.54766679
51Aplasia/Hypoplasia of the tongue (HP:0010295)2.54613504
52Abnormality of calcium-phosphate metabolism (HP:0100530)2.54147927
53Molar tooth sign on MRI (HP:0002419)2.51373701
54Abnormality of midbrain morphology (HP:0002418)2.51373701
55Abnormality of dental color (HP:0011073)2.49897453
56Wide anterior fontanel (HP:0000260)2.49179384
57Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.49141560
58Congenital sensorineural hearing impairment (HP:0008527)2.48782323
59Aneurysm (HP:0002617)2.43725436
60Bowel diverticulosis (HP:0005222)2.42365508
61Delayed gross motor development (HP:0002194)2.41798069
62Abnormal urine output (HP:0012590)2.40474620
63Camptodactyly of toe (HP:0001836)2.38140143
64Tibial bowing (HP:0002982)2.37376223
65Abnormality of the phalanges of the 5th finger (HP:0004213)2.36746066
66Bell-shaped thorax (HP:0001591)2.34670057
67Abnormality of the 2nd finger (HP:0004100)2.34539959
68Joint laxity (HP:0001388)2.34511974
69Absent phalangeal crease (HP:0006109)2.34059961
70Abnormality of the dental pulp (HP:0006479)2.33847968
71Osteolytic defects of the phalanges of the hand (HP:0009771)2.33202575
72Osteolytic defects of the hand bones (HP:0009699)2.33202575
73Osteomalacia (HP:0002749)2.32962024
74Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.32359304
75Abnormality of renal excretion (HP:0011036)2.31308324
76Abnormal delivery (HP:0001787)2.30880292
77Short middle phalanx of the 5th finger (HP:0004220)2.30213819
78Slender build (HP:0001533)2.28862861
79Femoral bowing (HP:0002980)2.28684390
80Lymphangioma (HP:0100764)2.27718103
81Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.26284619
82Abnormality of the acetabulum (HP:0003170)2.25425208
83Elbow flexion contracture (HP:0002987)2.24219059
84Spondylolisthesis (HP:0003302)2.23770969
85Hypoplasia of the uterus (HP:0000013)2.22376737
86Increased variability in muscle fiber diameter (HP:0003557)2.21874611
87Mildly elevated creatine phosphokinase (HP:0008180)2.21567440
88Fibular aplasia (HP:0002990)2.21483612
89Pulmonary infiltrates (HP:0002113)2.20596493
90Coronal craniosynostosis (HP:0004440)2.20168224
91Hypoplastic ischia (HP:0003175)2.16011917
92Broad ribs (HP:0000885)2.15994311
93Popliteal pterygium (HP:0009756)2.15649071
94Abnormality of glutamine family amino acid metabolism (HP:0010902)2.15492744
95True hermaphroditism (HP:0010459)2.15479890
96Neoplasm of the heart (HP:0100544)2.15292975
97Ectopia lentis (HP:0001083)2.15223160
98Ulnar bowing (HP:0003031)2.14254322
99Lipoatrophy (HP:0100578)2.13644343
100Gout (HP:0001997)2.13334149
101Absent frontal sinuses (HP:0002688)2.09500897
102Knee flexion contracture (HP:0006380)2.08983824
103Striae distensae (HP:0001065)2.08307859
104Infantile muscular hypotonia (HP:0008947)2.07653563
105Facial shape deformation (HP:0011334)2.07310564
106Potter facies (HP:0002009)2.07310564
107Mitral regurgitation (HP:0001653)2.05276845
108Short nail (HP:0001799)2.03692374
109Muscle fiber splitting (HP:0003555)2.03598439
110Deviation of the hallux (HP:0010051)2.02573024
111Generalized hypopigmentation of hair (HP:0011358)1.99536505
112Abnormality of the proximal phalanges of the hand (HP:0009834)1.99189746
113Nephronophthisis (HP:0000090)1.99148447
114Thoracolumbar scoliosis (HP:0002944)1.98580542
115Cardiovascular calcification (HP:0011915)1.97990075
116Osteoarthritis (HP:0002758)1.96860914
117Mitral stenosis (HP:0001718)1.95981484
118Abnormal finger flexion creases (HP:0006143)1.95721429
119Mesomelia (HP:0003027)1.93732059
120Hallux valgus (HP:0001822)1.93011331
121Abnormality of the frontal sinuses (HP:0002687)1.92914969
122Aplasia/Hypoplasia of the fibula (HP:0006492)1.92616915
123Hyporeflexia of lower limbs (HP:0002600)1.92211074
124Buphthalmos (HP:0000557)1.91290037
125Aplasia of the musculature (HP:0100854)1.90712678
126Astrocytoma (HP:0009592)1.90558408
127Abnormality of the astrocytes (HP:0100707)1.90558408
128Pancreatic fibrosis (HP:0100732)1.90048228
129Hip contracture (HP:0003273)1.89681067
130Right ventricular cardiomyopathy (HP:0011663)1.89305293
131Abnormality of the middle phalanges of the toes (HP:0010183)1.89297869
132Pancreatic cysts (HP:0001737)1.87847426
133Spinal cord compression (HP:0002176)1.87397360
134Aortic regurgitation (HP:0001659)1.86729260
135Platyspondyly (HP:0000926)1.86237575
136Increased number of teeth (HP:0011069)1.85576256
137Abnormality of the renal medulla (HP:0100957)1.84822637
138Flared iliac wings (HP:0002869)1.84632474
139Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.84074311
140Abnormality of the right ventricle (HP:0001707)1.84018389
141Abnormality of the ischium (HP:0003174)1.83738713
142Neoplasm of the lung (HP:0100526)1.83668888
143Sensory axonal neuropathy (HP:0003390)1.83576366
144Osteopenia (HP:0000938)1.82049494
145Abnormality of skeletal muscle fiber size (HP:0012084)1.81728531
146Broad long bones (HP:0005622)1.80423229
147Persistence of primary teeth (HP:0006335)1.79695532
148Abnormality of the costochondral junction (HP:0000919)1.78699847
149Congenital glaucoma (HP:0001087)1.78688692
150Coxa vara (HP:0002812)1.76104478
151Short 4th metacarpal (HP:0010044)1.75856274
152Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.75856274
153Vascular calcification (HP:0004934)1.75403539
154Short 5th finger (HP:0009237)1.74816631
155Hypoplasia of the iris (HP:0007676)1.74526893
156Mild short stature (HP:0003502)1.73869030
157Subacute progressive viral hepatitis (HP:0006572)1.73009240
158Corneal dystrophy (HP:0001131)1.72995212
159Disproportionate tall stature (HP:0001519)1.72537029
160Generalized amyotrophy (HP:0003700)1.71981521
161Scapular winging (HP:0003691)1.71312575
162Aplasia/Hypoplasia of the scapulae (HP:0006713)1.71297551
163Hypoplastic scapulae (HP:0000882)1.71297551
164Reduced subcutaneous adipose tissue (HP:0003758)1.71111375
165Short hallux (HP:0010109)1.70682038
166Breech presentation (HP:0001623)1.69622566
167Joint contractures involving the joints of the feet (HP:0100492)1.69025840
168Flexion contracture of toe (HP:0005830)1.69025840
169Venous abnormality (HP:0002624)1.68790123
170Round ear (HP:0100830)1.67155697
171Chondrocalcinosis (HP:0000934)1.65513217
172Limited hip movement (HP:0008800)1.65472027
173Hypokalemic alkalosis (HP:0001949)1.64863528
174Metaphyseal cupping (HP:0003021)1.64394754
175Focal segmental glomerulosclerosis (HP:0000097)1.63456704
176Venous insufficiency (HP:0005293)1.63088418

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR24.69078015
2TTN4.47086172
3TAF13.89552620
4PDGFRA3.56604982
5NTRK23.35711051
6TRIB33.26462185
7LATS13.15637027
8STK242.99781636
9MAP3K122.69745947
10WNK42.66330159
11LATS22.42844247
12FRK2.27154528
13FER2.19419338
14STK38L2.12966591
15PKN22.07903246
16RIPK12.06716527
17GRK12.02330603
18PTK21.99642935
19EPHA31.93253663
20EPHB21.91718293
21SIK11.83815216
22MET1.82543891
23PAK31.81187495
24PTK61.79888803
25TRIM281.77114560
26MAP4K21.74437299
27TGFBR21.72381254
28WNK31.71130513
29NEK91.65318019
30ERN11.65184240
31TNIK1.58172498
32PLK21.57660361
33ADRBK21.54424066
34PAK21.53999745
35LRRK21.49406564
36MUSK1.47898378
37AKT31.47415601
38BMPR1B1.45518897
39PAK41.45164119
40EIF2AK31.41089578
41MYLK1.38695774
42PIK3CA1.37757243
43BLK1.33316423
44DMPK1.32274711
45STK31.30430915
46FGFR21.30313612
47TRPM71.30100636
48OXSR11.26936310
49INSRR1.26133560
50PDGFRB1.25437412
51BMX1.24697553
52MAP3K51.20356505
53ROCK11.18760959
54EPHA21.17589607
55EPHB11.15489839
56STK391.14536003
57GRK71.14222681
58CASK1.09601362
59WNK11.09084022
60FGFR11.07182623
61LMTK21.06231971
62TESK11.05897519
63BMPR21.05746700
64PRKD21.03494733
65ACVR1B1.03131135
66LIMK10.96701650
67MST40.93043221
68RPS6KA40.91420235
69MTOR0.89450939
70NTRK10.89284429
71ILK0.89212318
72ERBB40.89160965
73NUAK10.89021174
74PTK2B0.84143832
75PRKD10.80222876
76MST1R0.76503448
77FLT30.76314158
78ROCK20.75509201
79PINK10.75440938
80CDK80.75179372
81BRSK20.70911525
82MAPK130.70847892
83FGFR40.70518353
84PRKD30.68485528
85SCYL20.67414405
86PKN10.65485643
87GRK50.64208745
88ZAK0.64067670
89MAP2K10.61361700
90PRKCH0.60624878
91STK380.60248437
92GSK3A0.59825748
93PRKCE0.58768406
94STK100.58570320
95IKBKB0.57460262
96DYRK1B0.56083383
97MAPKAPK50.54674684
98INSR0.53454762
99OBSCN0.53370636
100CAMK2A0.51067337
101TEC0.49597841
102JAK10.46680493
103SIK30.46430854
104PDK40.45921615
105PDK30.45921615
106CDC42BPA0.45257031
107CAMK1D0.44345860
108PRKAA10.43687544
109PRKCQ0.43200455
110RET0.42822522
111ABL20.42650884
112MAPK150.42276964
113MAP3K70.41907302
114TGFBR10.41300326
115PLK30.40964379
116MAP3K30.40464711
117ADRBK10.39069632
118DAPK30.39028804
119PRKG10.38677952
120ERBB30.37515933
121MAP2K20.37378239
122SRC0.36797882
123PRKACA0.35346305
124JAK30.34456975
125CAMK2D0.34111711
126CDK60.33615252
127CSNK1A1L0.33552752
128STK160.33388309
129ERBB20.30776550
130CAMK2G0.29902371
131CSNK1G10.29721708
132PIK3CG0.29698956
133IGF1R0.29303952
134KIT0.28654877
135NME20.28519154
136HIPK20.28275747
137PRKCI0.28059674
138PRKCA0.27332421
139ABL10.27270974
140MAP3K80.26610959
141TIE10.25730278
142FGFR30.25623258
143CAMK1G0.24249714
144MAP3K20.23523298
145PDK20.23522818
146BCR0.23398372
147PAK10.22951373
148PRKG20.20529140

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.78421564
2Protein digestion and absorption_Homo sapiens_hsa049743.77358744
3Focal adhesion_Homo sapiens_hsa045103.29999716
4Linoleic acid metabolism_Homo sapiens_hsa005912.72300601
5Olfactory transduction_Homo sapiens_hsa047402.70977029
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.29248276
7Adherens junction_Homo sapiens_hsa045202.28685023
8Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.21961058
9Proteoglycans in cancer_Homo sapiens_hsa052052.19478713
10Dilated cardiomyopathy_Homo sapiens_hsa054142.13036819
11Amoebiasis_Homo sapiens_hsa051462.04523675
12Small cell lung cancer_Homo sapiens_hsa052221.97152227
13Bladder cancer_Homo sapiens_hsa052191.87878266
14Hippo signaling pathway_Homo sapiens_hsa043901.86081923
15AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.78359566
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.75996306
17Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.71141840
18PI3K-Akt signaling pathway_Homo sapiens_hsa041511.66471063
19TGF-beta signaling pathway_Homo sapiens_hsa043501.65852606
20Basal cell carcinoma_Homo sapiens_hsa052171.65396853
21Nitrogen metabolism_Homo sapiens_hsa009101.63960767
22Retinol metabolism_Homo sapiens_hsa008301.56368699
23Malaria_Homo sapiens_hsa051441.53714302
24Tight junction_Homo sapiens_hsa045301.52706846
25Hedgehog signaling pathway_Homo sapiens_hsa043401.52619732
26Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.51724899
27Melanoma_Homo sapiens_hsa052181.51660296
28Circadian rhythm_Homo sapiens_hsa047101.50989505
29Maturity onset diabetes of the young_Homo sapiens_hsa049501.50327301
30Arachidonic acid metabolism_Homo sapiens_hsa005901.49818614
31Chemical carcinogenesis_Homo sapiens_hsa052041.45299266
32Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.44339430
33Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.43775518
34Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.43501635
35Phototransduction_Homo sapiens_hsa047441.43210794
36Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.41835029
37MicroRNAs in cancer_Homo sapiens_hsa052061.41052889
38Caffeine metabolism_Homo sapiens_hsa002321.40587605
39Salivary secretion_Homo sapiens_hsa049701.38321480
40Complement and coagulation cascades_Homo sapiens_hsa046101.36944888
41Bile secretion_Homo sapiens_hsa049761.36395732
42Prostate cancer_Homo sapiens_hsa052151.35617352
43Leukocyte transendothelial migration_Homo sapiens_hsa046701.34326007
44Regulation of actin cytoskeleton_Homo sapiens_hsa048101.31845154
45Sulfur relay system_Homo sapiens_hsa041221.30448817
46Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.29801809
47Collecting duct acid secretion_Homo sapiens_hsa049661.29591385
48Gastric acid secretion_Homo sapiens_hsa049711.29400077
49Steroid hormone biosynthesis_Homo sapiens_hsa001401.28414440
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.25215509
51Vascular smooth muscle contraction_Homo sapiens_hsa042701.22048250
52Dorso-ventral axis formation_Homo sapiens_hsa043201.20442583
53Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.19790592
54Vitamin B6 metabolism_Homo sapiens_hsa007501.09897973
55Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.08538096
56Insulin secretion_Homo sapiens_hsa049111.08505323
57Lysine degradation_Homo sapiens_hsa003101.07431571
58Chronic myeloid leukemia_Homo sapiens_hsa052201.07265708
59Fatty acid degradation_Homo sapiens_hsa000711.06678492
60Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.04367237
61Fat digestion and absorption_Homo sapiens_hsa049751.02926360
62Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.01205663
63Ether lipid metabolism_Homo sapiens_hsa005650.99599225
64Fructose and mannose metabolism_Homo sapiens_hsa000510.99564626
65Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.99252719
66Glutamatergic synapse_Homo sapiens_hsa047240.98921935
67GABAergic synapse_Homo sapiens_hsa047270.98692390
68Taste transduction_Homo sapiens_hsa047420.97914262
69Axon guidance_Homo sapiens_hsa043600.97158744
70Pathways in cancer_Homo sapiens_hsa052000.96200005
71Circadian entrainment_Homo sapiens_hsa047130.96024398
72Viral myocarditis_Homo sapiens_hsa054160.95823703
73Morphine addiction_Homo sapiens_hsa050320.93869208
74Cocaine addiction_Homo sapiens_hsa050300.93064043
75African trypanosomiasis_Homo sapiens_hsa051430.91248226
76Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.91078497
77Rap1 signaling pathway_Homo sapiens_hsa040150.90940256
78Wnt signaling pathway_Homo sapiens_hsa043100.90559407
79Pancreatic cancer_Homo sapiens_hsa052120.88334767
80Serotonergic synapse_Homo sapiens_hsa047260.88176872
81Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.87924577
82Glioma_Homo sapiens_hsa052140.86529744
83Mineral absorption_Homo sapiens_hsa049780.85345038
84Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.84518827
85Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.84363205
86Calcium signaling pathway_Homo sapiens_hsa040200.84313475
87Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.82706406
88Propanoate metabolism_Homo sapiens_hsa006400.81946869
89Primary bile acid biosynthesis_Homo sapiens_hsa001200.80216158
90Sulfur metabolism_Homo sapiens_hsa009200.78996312
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.77620553
92SNARE interactions in vesicular transport_Homo sapiens_hsa041300.76568177
93Thyroid hormone synthesis_Homo sapiens_hsa049180.75352700
94Butanoate metabolism_Homo sapiens_hsa006500.74965642
95Platelet activation_Homo sapiens_hsa046110.74590569
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.74534426
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74479396
98Fatty acid metabolism_Homo sapiens_hsa012120.73522442
99Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.73097132
100Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.72358458
101cAMP signaling pathway_Homo sapiens_hsa040240.71106500
102Sphingolipid metabolism_Homo sapiens_hsa006000.70777910
103Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.70400369
104Pancreatic secretion_Homo sapiens_hsa049720.69234358
105Renal cell carcinoma_Homo sapiens_hsa052110.68430969
106Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.68201633
107Insulin resistance_Homo sapiens_hsa049310.67634051
108Tryptophan metabolism_Homo sapiens_hsa003800.67606839
109Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.66483057
110Glutathione metabolism_Homo sapiens_hsa004800.66481599
111Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.66073626
1122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.64045485
113Endometrial cancer_Homo sapiens_hsa052130.62984474
114Aldosterone synthesis and secretion_Homo sapiens_hsa049250.62548010
115TNF signaling pathway_Homo sapiens_hsa046680.61566368
116Melanogenesis_Homo sapiens_hsa049160.61149357
117Central carbon metabolism in cancer_Homo sapiens_hsa052300.60885431
118Arginine and proline metabolism_Homo sapiens_hsa003300.60704284
119Renin-angiotensin system_Homo sapiens_hsa046140.59089532
120Glycosaminoglycan degradation_Homo sapiens_hsa005310.58919210
121Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.58578496
122Toxoplasmosis_Homo sapiens_hsa051450.57236941
123Pentose and glucuronate interconversions_Homo sapiens_hsa000400.56101822
124Ovarian steroidogenesis_Homo sapiens_hsa049130.55829975
125Starch and sucrose metabolism_Homo sapiens_hsa005000.55796365
126Vitamin digestion and absorption_Homo sapiens_hsa049770.54872794
127PPAR signaling pathway_Homo sapiens_hsa033200.52675772
128AMPK signaling pathway_Homo sapiens_hsa041520.52290813
129HTLV-I infection_Homo sapiens_hsa051660.51627606
130ABC transporters_Homo sapiens_hsa020100.51023859
131Amphetamine addiction_Homo sapiens_hsa050310.51004237
132p53 signaling pathway_Homo sapiens_hsa041150.50027977
133Lysosome_Homo sapiens_hsa041420.49455863
134Phagosome_Homo sapiens_hsa041450.47096488
135Selenocompound metabolism_Homo sapiens_hsa004500.46894206
136Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46365149
137Other glycan degradation_Homo sapiens_hsa005110.45956685
138Ras signaling pathway_Homo sapiens_hsa040140.44985532
139Shigellosis_Homo sapiens_hsa051310.44643869
140Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.43443638
141Cysteine and methionine metabolism_Homo sapiens_hsa002700.43288495
142Gap junction_Homo sapiens_hsa045400.43164385
143Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.43156461
144Cholinergic synapse_Homo sapiens_hsa047250.42927749
145Oxytocin signaling pathway_Homo sapiens_hsa049210.42415781
146FoxO signaling pathway_Homo sapiens_hsa040680.42225949
147N-Glycan biosynthesis_Homo sapiens_hsa005100.41196519
148Endocytosis_Homo sapiens_hsa041440.40464475
149Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40308468
150Thyroid cancer_Homo sapiens_hsa052160.39997073
151Rheumatoid arthritis_Homo sapiens_hsa053230.39781615
152Vibrio cholerae infection_Homo sapiens_hsa051100.39641325
153Protein export_Homo sapiens_hsa030600.39404092
154Oxidative phosphorylation_Homo sapiens_hsa001900.39070861
155Adipocytokine signaling pathway_Homo sapiens_hsa049200.39024618
156cGMP-PKG signaling pathway_Homo sapiens_hsa040220.38970165
157Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38838193
158Phospholipase D signaling pathway_Homo sapiens_hsa040720.37682969
159Pyruvate metabolism_Homo sapiens_hsa006200.37534719

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