BHLHA15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1digestion (GO:0007586)8.55493498
2activation of signaling protein activity involved in unfolded protein response (GO:0006987)7.46554743
3positive regulation of nuclease activity (GO:0032075)7.15665632
4signal peptide processing (GO:0006465)6.80047701
5COPII vesicle coating (GO:0048208)6.79892199
6regulation of nuclease activity (GO:0032069)6.55728483
7retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)6.50004758
8endoplasmic reticulum unfolded protein response (GO:0030968)6.47510887
9transcytosis (GO:0045056)6.32321209
10cellular response to unfolded protein (GO:0034620)6.28772077
11ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)6.10212406
12regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022356.05934051
13ER-nucleus signaling pathway (GO:0006984)6.00397345
14cellular response to topologically incorrect protein (GO:0035967)5.94339241
15response to endoplasmic reticulum stress (GO:0034976)5.90332359
16valine metabolic process (GO:0006573)5.72961440
17intestinal epithelial cell development (GO:0060576)5.67906336
18protein maturation by protein folding (GO:0022417)5.59179442
19ER overload response (GO:0006983)5.47565208
20proline biosynthetic process (GO:0006561)5.44050953
21protein N-linked glycosylation via asparagine (GO:0018279)5.36716010
22peptidyl-asparagine modification (GO:0018196)5.34387024
23detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)5.24146678
24intestinal absorption (GO:0050892)5.10363683
25peptidyl-proline hydroxylation (GO:0019511)5.10187512
26vesicle coating (GO:0006901)4.96469139
27response to unfolded protein (GO:0006986)4.95659145
28protein N-linked glycosylation (GO:0006487)4.92398483
29cobalamin metabolic process (GO:0009235)4.76269793
30regulation of cholesterol homeostasis (GO:2000188)4.72605106
31response to topologically incorrect protein (GO:0035966)4.71935918
32zinc ion transport (GO:0006829)4.70603918
33regulation of glucose import in response to insulin stimulus (GO:2001273)4.68417629
34GDP-mannose metabolic process (GO:0019673)4.61829710
35cysteine metabolic process (GO:0006534)4.59458514
36UDP-N-acetylglucosamine metabolic process (GO:0006047)4.47950373
37endocrine pancreas development (GO:0031018)4.42497871
38branched-chain amino acid catabolic process (GO:0009083)4.31144832
39branched-chain amino acid metabolic process (GO:0009081)4.25852253
404-hydroxyproline metabolic process (GO:0019471)4.19891978
41protein hydroxylation (GO:0018126)4.14192679
42glandular epithelial cell differentiation (GO:0002067)4.10030730
43regulation of translational fidelity (GO:0006450)3.98625532
44sequestering of metal ion (GO:0051238)3.93380038
45maintenance of protein localization in organelle (GO:0072595)3.92199613
46glycolipid catabolic process (GO:0019377)3.88718185
47negative regulation of digestive system process (GO:0060457)3.79668620
48ER to Golgi vesicle-mediated transport (GO:0006888)3.74691581
49cell redox homeostasis (GO:0045454)3.74533905
50cholesterol catabolic process (GO:0006707)3.73060817
51sterol catabolic process (GO:0016127)3.73060817
52regulation of phospholipase A2 activity (GO:0032429)3.63867680
53positive regulation of growth hormone secretion (GO:0060124)3.61521007
54complement activation, classical pathway (GO:0006958)3.60940580
55intra-Golgi vesicle-mediated transport (GO:0006891)3.60724076
56cellular modified amino acid catabolic process (GO:0042219)3.55581477
57proline metabolic process (GO:0006560)3.55166752
58ceramide catabolic process (GO:0046514)3.54410899
59membrane lipid catabolic process (GO:0046466)3.53001873
60peptide catabolic process (GO:0043171)3.52570241
61L-alpha-amino acid transmembrane transport (GO:1902475)3.50319452
62leukotriene metabolic process (GO:0006691)3.44811061
63negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.39789115
64bundle of His cell to Purkinje myocyte communication (GO:0086069)3.39343303
65serine family amino acid biosynthetic process (GO:0009070)3.37732910
66columnar/cuboidal epithelial cell development (GO:0002066)3.33957368
67activation of Rac GTPase activity (GO:0032863)3.33449700
68nucleotide-sugar biosynthetic process (GO:0009226)3.33280689
69mannose metabolic process (GO:0006013)3.31740156
70* Golgi organization (GO:0007030)3.30218496
71lung secretory cell differentiation (GO:0061140)3.27943800
72creatine metabolic process (GO:0006600)3.26119611
73glutamine family amino acid biosynthetic process (GO:0009084)3.23909542
74nucleotide-sugar metabolic process (GO:0009225)3.19260945
75protein localization to Golgi apparatus (GO:0034067)3.18860178
76regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.18828053
77nucleoside diphosphate catabolic process (GO:0009134)3.15684239
78N-glycan processing (GO:0006491)3.10688168
79insulin-like growth factor receptor signaling pathway (GO:0048009)3.08329465
80detection of chemical stimulus involved in sensory perception of taste (GO:0050912)3.06860529
81regulation of cholesterol biosynthetic process (GO:0045540)3.05459925
82antibacterial humoral response (GO:0019731)3.03662694
83fucose metabolic process (GO:0006004)3.02992457
84antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.01481057
85leukotriene biosynthetic process (GO:0019370)2.94323921
86NADH metabolic process (GO:0006734)2.93598181
87peptide hormone processing (GO:0016486)2.91098736
88urea cycle (GO:0000050)2.90239568
89negative regulation of viral release from host cell (GO:1902187)2.88528424
90muscle organ morphogenesis (GO:0048644)2.87218131
91sulfur amino acid catabolic process (GO:0000098)2.86712370
92negative regulation of glycogen biosynthetic process (GO:0045719)2.85992824
93polarized epithelial cell differentiation (GO:0030859)2.85523875
94peptidyl-glutamic acid carboxylation (GO:0017187)2.83475663
95protein carboxylation (GO:0018214)2.83475663
96macromolecule glycosylation (GO:0043413)2.82970856
97protein glycosylation (GO:0006486)2.82970856
98glutamine metabolic process (GO:0006541)2.82776535
99glutathione biosynthetic process (GO:0006750)2.82729532
100antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.82165370
101regulation of growth hormone secretion (GO:0060123)2.80413073
102antimicrobial humoral response (GO:0019730)2.80378105
103intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.79920248
104epithelial cell maturation (GO:0002070)2.79338088
105glycosylation (GO:0070085)2.78841103
106negative regulation of cell size (GO:0045792)2.78733738
107positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.76047325
108Golgi vesicle transport (GO:0048193)2.75413973
109serine transport (GO:0032329)2.73786991
110urea metabolic process (GO:0019627)2.73662063
111apoptotic process involved in morphogenesis (GO:0060561)2.72932035
112very-low-density lipoprotein particle assembly (GO:0034379)2.72913616
113fatty acid derivative biosynthetic process (GO:1901570)2.72578934
114icosanoid biosynthetic process (GO:0046456)2.72578934
115biotin metabolic process (GO:0006768)2.70313415
116complement activation (GO:0006956)2.69212938
117positive regulation of glycoprotein metabolic process (GO:1903020)2.68874195
118L-serine transport (GO:0015825)2.68693420
119folic acid metabolic process (GO:0046655)2.67694704
120mitotic chromosome condensation (GO:0007076)2.66493610
121embryonic process involved in female pregnancy (GO:0060136)2.66377592
122cellular response to virus (GO:0098586)2.64951949
123regulation of cholesterol metabolic process (GO:0090181)2.64005231
124positive regulation of keratinocyte differentiation (GO:0045618)2.63955183
125protein targeting to Golgi (GO:0000042)2.63689456
126endoplasmic reticulum organization (GO:0007029)2.62385999
127spliceosomal tri-snRNP complex assembly (GO:0000244)2.61323756
128fucosylation (GO:0036065)2.61177009
129detection of chemical stimulus involved in sensory perception (GO:0050907)2.59703744
130unsaturated fatty acid biosynthetic process (GO:0006636)2.59668291
131post-translational protein modification (GO:0043687)2.59111750
132protein localization to endosome (GO:0036010)2.58978036
133innate immune response in mucosa (GO:0002227)2.58700412
134maternal placenta development (GO:0001893)2.58325244
135positive regulation of heat generation (GO:0031652)2.56266534
136receptor catabolic process (GO:0032801)2.56052762
137positive regulation of Cdc42 GTPase activity (GO:0043089)2.56013785
138gonadal mesoderm development (GO:0007506)2.54028326
139antigen processing and presentation of endogenous antigen (GO:0019883)2.51603015
140L-serine metabolic process (GO:0006563)2.51158373
141glutamate metabolic process (GO:0006536)2.48673821
142low-density lipoprotein particle clearance (GO:0034383)2.47230396
143cell-substrate adherens junction assembly (GO:0007045)2.46550029
144focal adhesion assembly (GO:0048041)2.46550029
145nitrogen cycle metabolic process (GO:0071941)2.46419394
146detection of molecule of bacterial origin (GO:0032490)2.44418544
147positive regulation of histone deacetylation (GO:0031065)2.44296588
148branching involved in mammary gland duct morphogenesis (GO:0060444)2.42607286
149positive regulation by symbiont of host defense response (GO:0052509)2.42195130
150modulation by symbiont of host defense response (GO:0052031)2.42195130
151modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.42195130
152modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.42195130
153positive regulation by organism of defense response of other organism involved in symbiotic interact2.42195130
154modulation by symbiont of host immune response (GO:0052553)2.42195130
155glucose catabolic process (GO:0006007)2.39658959
156nonribosomal peptide biosynthetic process (GO:0019184)2.39506977
157plasma lipoprotein particle assembly (GO:0034377)2.38003761
158regulation of fatty acid beta-oxidation (GO:0031998)2.37052979
159regulation of mammary gland epithelial cell proliferation (GO:0033599)2.36901894
160exocrine pancreas development (GO:0031017)12.4567584
161maintenance of protein localization in endoplasmic reticulum (GO:0035437)11.0691726
162Golgi transport vesicle coating (GO:0048200)10.9745644
163COPI coating of Golgi vesicle (GO:0048205)10.9745644
164protein retention in ER lumen (GO:0006621)10.7652544
165intestinal cholesterol absorption (GO:0030299)10.1381321

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.47979371
2STAT6_21828071_ChIP-Seq_BEAS2B_Human3.96893924
3STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse3.39907902
4SOX2_27498859_Chip-Seq_STOMACH_Mouse3.35246211
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.10836894
6GATA1_22025678_ChIP-Seq_K562_Human2.99419630
7TP63_17297297_ChIP-ChIP_HaCaT_Human2.98222233
8VDR_21846776_ChIP-Seq_THP-1_Human2.96992926
9ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.82744390
10ESR1_21235772_ChIP-Seq_MCF-7_Human2.59541497
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.57409944
12E2F7_22180533_ChIP-Seq_HELA_Human2.50428222
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.48995581
14GATA6_25053715_ChIP-Seq_YYC3_Human2.45179694
15* GATA4_25053715_ChIP-Seq_YYC3_Human2.37509682
16DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.32340466
17FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human2.30144109
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.20805059
19ESR2_21235772_ChIP-Seq_MCF-7_Human2.20477183
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.15942353
21CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.06551926
22* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.05589185
23PPARA_22158963_ChIP-Seq_LIVER_Mouse1.99912913
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.99358453
25PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.96324810
26TCF7_22412390_ChIP-Seq_EML_Mouse1.93711566
27CHD1_26751641_Chip-Seq_LNCaP_Human1.92044076
28LXR_22158963_ChIP-Seq_LIVER_Mouse1.81799971
29ERG_21242973_ChIP-ChIP_JURKAT_Human1.81330840
30* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.79026619
31FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.78264796
32ELK3_25401928_ChIP-Seq_HUVEC_Human1.78011313
33TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.76361950
34DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.73590657
35KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.72398381
36KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.72398381
37KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.72398381
38KDM2B_26808549_Chip-Seq_SUP-B15_Human1.72335871
39RXR_22158963_ChIP-Seq_LIVER_Mouse1.69664270
40* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.68215482
41SOX2_20726797_ChIP-Seq_SW620_Human1.62879351
42MAF_26560356_Chip-Seq_TH1_Human1.62434223
43PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.61645388
44FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.60829809
45SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.59648963
46VDR_24763502_ChIP-Seq_THP-1_Human1.58129373
47EGR1_19374776_ChIP-ChIP_THP-1_Human1.57765530
48RUNX1_27514584_Chip-Seq_MCF-7_Human1.54936658
49PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.54083702
50NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.53745396
51FOXA1_25552417_ChIP-Seq_VCAP_Human1.52767904
52THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.50262876
53GATA3_24758297_ChIP-Seq_MCF-7_Human1.49762962
54EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.49620374
55TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49546062
56FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.47272815
57MYC_18555785_ChIP-Seq_MESCs_Mouse1.46931725
58ESR1_20079471_ChIP-ChIP_T-47D_Human1.46448798
59HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.43989663
60HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.43395992
61RARG_19884340_ChIP-ChIP_MEFs_Mouse1.43041987
62KDM2B_26808549_Chip-Seq_DND41_Human1.42141193
63CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.41994203
64ZNF217_24962896_ChIP-Seq_MCF-7_Human1.41634400
65* MAF_26560356_Chip-Seq_TH2_Human1.41532613
66ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.41530503
67FOXM1_23109430_ChIP-Seq_U2OS_Human1.40906955
68MYC_22102868_ChIP-Seq_BL_Human1.40855750
69FOXA2_19822575_ChIP-Seq_HepG2_Human1.38755022
70ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.38432652
71XRN2_22483619_ChIP-Seq_HELA_Human1.38129503
72ERG_20517297_ChIP-Seq_VCAP_Human1.37797361
73TET1_21451524_ChIP-Seq_MESCs_Mouse1.37589940
74AR_21909140_ChIP-Seq_LNCAP_Human1.37552239
75RACK7_27058665_Chip-Seq_MCF-7_Human1.37429821
76CREB1_26743006_Chip-Seq_LNCaP_Human1.37081253
77HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.36901536
78SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.36345996
79PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.35000630
80PKCTHETA_26484144_Chip-Seq_BREAST_Human1.32562029
81MYC_19079543_ChIP-ChIP_MESCs_Mouse1.31943877
82BRD4_27068464_Chip-Seq_AML-cells_Mouse1.31457221
83CTCF_27219007_Chip-Seq_ERYTHROID_Human1.30451529
84TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29692250
85SMC4_20622854_ChIP-Seq_HELA_Human1.29536316
86FOXO3_23340844_ChIP-Seq_DLD1_Human1.28733988
87UTX_26944678_Chip-Seq_JUKART_Human1.28642899
88CLOCK_20551151_ChIP-Seq_293T_Human1.28444852
89SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.28355328
90MYC_18358816_ChIP-ChIP_MESCs_Mouse1.27734826
91CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.26518526
92FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.26316958
93CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.25091057
94STAT3_1855785_ChIP-Seq_MESCs_Mouse1.24562725
95PU.1_20513432_ChIP-Seq_Bcells_Mouse1.24131852
96KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.23887083
97SA1_27219007_Chip-Seq_ERYTHROID_Human1.23567761
98SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.20030541
99BCOR_27268052_Chip-Seq_Bcells_Human1.18192802
100SRY_22984422_ChIP-ChIP_TESTIS_Rat1.18020194
101PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.15487175
102KLF4_18555785_ChIP-Seq_MESCs_Mouse1.14765390
103CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.14519457
104RARA_24833708_ChIP-Seq_LIVER_Mouse1.14362023
105LXR_22292898_ChIP-Seq_THP-1_Human1.14252284
106SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.14177428
107ATF3_27146783_Chip-Seq_COLON_Human1.13703167
108KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.13325218
109KDM2B_26808549_Chip-Seq_K562_Human1.12767775
110STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.12322508
111IRF1_19129219_ChIP-ChIP_H3396_Human1.11051815
112RUNX1_22412390_ChIP-Seq_EML_Mouse1.09947517
113MYC_19030024_ChIP-ChIP_MESCs_Mouse1.09827592
114MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.08454799
115CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.07045511
116EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.05899231
117RARB_24833708_ChIP-Seq_LIVER_Mouse1.05233748
118CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.05152220
119UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.04611297
120SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04296740
121NELFA_20434984_ChIP-Seq_ESCs_Mouse1.04092804
122TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.03747896
123TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.03508272
124STAT4_19710469_ChIP-ChIP_TH1__Mouse1.03407169
125TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.02819153
126P63_26484246_Chip-Seq_KERATINOCYTES_Human1.02238288
127GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.01428529
128GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.01300043
129TBX20_22328084_ChIP-Seq_HEART_Mouse1.00518492
130TBX20_22080862_ChIP-Seq_HEART_Mouse1.00518492
131NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.98992972
132GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98080545
133KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.97477125
134ETS1_21867929_ChIP-Seq_TH2_Mouse0.97476230
135BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.97065808
136ERG_20887958_ChIP-Seq_HPC-7_Mouse0.96253495
137* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.94557268
138TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.93861882
139ETS1_22383799_ChIP-Seq_G1ME_Mouse0.93053183
140TBX5_21415370_ChIP-Seq_HL-1_Mouse0.91789800
141ZNF263_19887448_ChIP-Seq_K562_Human0.91353384
142FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.89417357
143TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88997299
144ZNF274_21170338_ChIP-Seq_K562_Hela0.87636674
145PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.87082198
146FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.86723641
147KDM5A_27292631_Chip-Seq_BREAST_Human0.84748278
148SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.84226474
149TP63_22573176_ChIP-Seq_HFKS_Human0.80132786
150PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.79779293
151GATA3_26560356_Chip-Seq_TH1_Human0.79652700
152NFIB_24661679_ChIP-Seq_LUNG_Mouse0.79569912
153* ESET_19884257_ChIP-Seq_ESCs_Mouse0.79090905
154GATA3_27048872_Chip-Seq_THYMUS_Human0.78413997
155P68_20966046_ChIP-Seq_HELA_Human0.76420684
156* FOXH1_21741376_ChIP-Seq_ESCs_Human0.75274902
157RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.74325546
158NCOR1_26117541_ChIP-Seq_K562_Human0.72646100
159ZFX_18555785_ChIP-Seq_MESCs_Mouse0.72028526

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001666_abnormal_nutrient_absorption7.26477877
2MP0005083_abnormal_biliary_tract6.82096376
3* MP0005220_abnormal_exocrine_pancreas5.27370864
4MP0005365_abnormal_bile_salt4.66922955
5MP0005451_abnormal_body_composition4.23550484
6MP0003868_abnormal_feces_composition4.01575749
7MP0004264_abnormal_extraembryonic_tissu3.90071230
8MP0002693_abnormal_pancreas_physiology3.80343916
9MP0005084_abnormal_gallbladder_morpholo3.21631614
10MP0010234_abnormal_vibrissa_follicle2.96494062
11* MP0001944_abnormal_pancreas_morphology2.86219563
12MP0009780_abnormal_chondrocyte_physiolo2.48065395
13MP0003283_abnormal_digestive_organ2.44640074
14MP0001664_abnormal_digestion2.43520336
15MP0003183_abnormal_peptide_metabolism2.39278765
16MP0005360_urolithiasis2.37068076
17MP0010386_abnormal_urinary_bladder2.33957459
18MP0003959_abnormal_lean_body2.31742858
19MP0002089_abnormal_postnatal_growth/wei2.09115093
20MP0005085_abnormal_gallbladder_physiolo2.04766579
21MP0004043_abnormal_pH_regulation1.99634535
22MP0004858_abnormal_nervous_system1.97607308
23MP0000685_abnormal_immune_system1.95853610
24MP0003693_abnormal_embryo_hatching1.93721914
25MP0001873_stomach_inflammation1.89368013
26MP0005058_abnormal_lysosome_morphology1.69189110
27MP0005310_abnormal_salivary_gland1.68007586
28MP0003303_peritoneal_inflammation1.65601300
29MP0002006_tumorigenesis1.64661753
30MP0002078_abnormal_glucose_homeostasis1.62316320
31MP0003453_abnormal_keratinocyte_physiol1.58583347
32MP0009333_abnormal_splenocyte_physiolog1.57524895
33MP0002909_abnormal_adrenal_gland1.56456837
34MP0002796_impaired_skin_barrier1.55251823
35MP0002877_abnormal_melanocyte_morpholog1.54968224
36MP0004947_skin_inflammation1.51271671
37MP0002277_abnormal_respiratory_mucosa1.48720398
38MP0000003_abnormal_adipose_tissue1.48101220
39MP0009643_abnormal_urine_homeostasis1.47880032
40MP0001835_abnormal_antigen_presentation1.47664976
41MP0003300_gastrointestinal_ulcer1.44562786
42MP0001765_abnormal_ion_homeostasis1.42469932
43MP0006054_spinal_hemorrhage1.41495296
44MP0003763_abnormal_thymus_physiology1.41490495
45MP0005666_abnormal_adipose_tissue1.36108671
46MP0009840_abnormal_foam_cell1.35369763
47MP0005501_abnormal_skin_physiology1.34804241
48MP0005387_immune_system_phenotype1.34649752
49MP0001790_abnormal_immune_system1.34649752
50MP0002396_abnormal_hematopoietic_system1.34366655
51MP0000566_synostosis1.33200922
52MP0003705_abnormal_hypodermis_morpholog1.32788344
53MP0005379_endocrine/exocrine_gland_phen1.31945756
54MP0000013_abnormal_adipose_tissue1.28107759
55MP0003111_abnormal_nucleus_morphology1.26701373
56MP0001348_abnormal_lacrimal_gland1.26108410
57MP0003436_decreased_susceptibility_to1.25987169
58MP0004233_abnormal_muscle_weight1.24292487
59MP0002009_preneoplasia1.22464095
60MP0005448_abnormal_energy_balance1.21849624
61MP0002896_abnormal_bone_mineralization1.21592295
62MP0010352_gastrointestinal_tract_polyps1.16213177
63MP0001730_embryonic_growth_arrest1.16054823
64MP0001661_extended_life_span1.15337181
65MP0008961_abnormal_basal_metabolism1.14778705
66MP0000462_abnormal_digestive_system1.14434991
67MP0002139_abnormal_hepatobiliary_system1.13408866
68MP0008260_abnormal_autophagy1.09957631
69MP0003566_abnormal_cell_adhesion1.09857300
70MP0001800_abnormal_humoral_immune1.09668023
71MP0001756_abnormal_urination1.08300765
72MP0000490_abnormal_crypts_of1.08048372
73MP0004782_abnormal_surfactant_physiolog1.07752253
74MP0003953_abnormal_hormone_level1.07747768
75MP0004957_abnormal_blastocyst_morpholog1.07742034
76MP0005332_abnormal_amino_acid1.06168956
77MP0001346_abnormal_lacrimal_gland1.06090871
78MP0005408_hypopigmentation1.04087137
79MP0002118_abnormal_lipid_homeostasis1.03637913
80MP0005409_darkened_coat_color1.03624843
81MP0001881_abnormal_mammary_gland1.02386659
82MP0002398_abnormal_bone_marrow1.00260445
83* MP0000858_altered_metastatic_potential1.00169846
84MP0005636_abnormal_mineral_homeostasis0.99809403
85MP0003638_abnormal_response/metabolism_0.97555474
86MP0000537_abnormal_urethra_morphology0.96227175
87MP0008004_abnormal_stomach_pH0.94755685
88MP0003077_abnormal_cell_cycle0.94296391
89MP0005025_abnormal_response_to0.92682320
90MP0003191_abnormal_cellular_cholesterol0.91398347
91MP0005381_digestive/alimentary_phenotyp0.90869543
92MP0003091_abnormal_cell_migration0.90692484
93MP0003195_calcinosis0.90252714
94* MP0000470_abnormal_stomach_morphology0.90038320
95MP0001216_abnormal_epidermal_layer0.88945033
96MP0002166_altered_tumor_susceptibility0.88943089
97MP0002928_abnormal_bile_duct0.88640467
98MP0002429_abnormal_blood_cell0.88135965
99MP0000350_abnormal_cell_proliferation0.88110659
100MP0002452_abnormal_antigen_presenting0.86461715
101MP0000716_abnormal_immune_system0.86105091
102MP0005646_abnormal_pituitary_gland0.85933452
103MP0000678_abnormal_parathyroid_gland0.85736074
104MP0000477_abnormal_intestine_morphology0.85684318
105MP0001849_ear_inflammation0.85223166
106MP0010094_abnormal_chromosome_stability0.85162948
107* MP0000613_abnormal_salivary_gland0.85003980
108MP0010329_abnormal_lipoprotein_level0.84781220
109MP0003252_abnormal_bile_duct0.84236259
110MP0002723_abnormal_immune_serum0.84209849
111MP0002086_abnormal_extraembryonic_tissu0.82743778
112MP0002098_abnormal_vibrissa_morphology0.82279117
113MP0001819_abnormal_immune_cell0.81270857
114MP0000703_abnormal_thymus_morphology0.80433258
115MP0002420_abnormal_adaptive_immunity0.80361278
116MP0005621_abnormal_cell_physiology0.79307494
117MP0003315_abnormal_perineum_morphology0.78270758
118MP0002080_prenatal_lethality0.77906448
119MP0002722_abnormal_immune_system0.77878001
120MP0004808_abnormal_hematopoietic_stem0.77207291
121MP0009931_abnormal_skin_appearance0.76773019
122MP0001663_abnormal_digestive_system0.76174924
123MP0003122_maternal_imprinting0.75447628
124MP0009384_cardiac_valve_regurgitation0.75117077
125MP0005000_abnormal_immune_tolerance0.74997493
126* MP0000598_abnormal_liver_morphology0.74743172
127MP0005535_abnormal_body_temperature0.73771894
128MP0006072_abnormal_retinal_apoptosis0.72923778
129MP0000371_diluted_coat_color0.72246882
130MP0005375_adipose_tissue_phenotype0.72017764
131MP0003795_abnormal_bone_structure0.68958140
132MP0002876_abnormal_thyroid_physiology0.67151674
133MP0003172_abnormal_lysosome_physiology0.66470437
134MP0005076_abnormal_cell_differentiation0.65129188
135MP0005187_abnormal_penis_morphology0.62983912
136MP0001845_abnormal_inflammatory_respons0.62746547
137MP0003045_fibrosis0.62676206
138MP0008789_abnormal_olfactory_epithelium0.62482247
139MP0000681_abnormal_thyroid_gland0.61844972
140MP0003866_abnormal_defecation0.61171745
141MP0002138_abnormal_hepatobiliary_system0.60994356
142MP0001731_abnormal_postnatal_growth0.59741273
143MP0005165_increased_susceptibility_to0.59324717
144MP0004185_abnormal_adipocyte_glucose0.58792105
145MP0005452_abnormal_adipose_tissue0.56726617
146MP0000538_abnormal_urinary_bladder0.55077715
147MP0002234_abnormal_pharynx_morphology0.54611230
148MP0005319_abnormal_enzyme/_coenzyme0.54364232
149MP0001270_distended_abdomen0.54275283
150MP0010678_abnormal_skin_adnexa0.53427022
151MP0009765_abnormal_xenobiotic_induced0.53259752
152MP0009642_abnormal_blood_homeostasis0.52354364
153MP0005334_abnormal_fat_pad0.51683092
154MP0000609_abnormal_liver_physiology0.50730936
155MP0000579_abnormal_nail_morphology0.48800051
156MP0002060_abnormal_skin_morphology0.46346258
157MP0010155_abnormal_intestine_physiology0.45831469
158MP0000367_abnormal_coat/_hair0.45809962
159MP0000627_abnormal_mammary_gland0.44811538
160MP0009703_decreased_birth_body0.43480207
161MP0000639_abnormal_adrenal_gland0.43320651

Predicted human phenotypes

RankGene SetZ-score
1Steatorrhea (HP:0002570)5.25506098
2Exocrine pancreatic insufficiency (HP:0001738)5.24652362
3Abnormality of the intrinsic pathway (HP:0010989)5.04724326
4Fat malabsorption (HP:0002630)4.55094065
5Hypoplasia of the pons (HP:0012110)4.52662684
6Abnormality of endocrine pancreas physiology (HP:0012093)4.43196068
7Abnormality of the pancreatic islet cells (HP:0006476)4.43196068
8Abnormal pancreas size (HP:0012094)4.35247063
9Hyperinsulinemic hypoglycemia (HP:0000825)4.34903690
10Vacuolated lymphocytes (HP:0001922)4.21838919
11Hypoglycemic seizures (HP:0002173)4.13235236
12Abnormality of the pons (HP:0007361)4.07505209
13Ketoacidosis (HP:0001993)4.01533450
14Hemorrhage of the eye (HP:0011885)3.99293257
15Hypoglycemic coma (HP:0001325)3.79834799
16Deep venous thrombosis (HP:0002625)3.78749633
17Gout (HP:0001997)3.78073826
18Flat acetabular roof (HP:0003180)3.67621801
19Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.65136146
20Abnormality of subcutaneous fat tissue (HP:0001001)3.53403111
21Symptomatic seizures (HP:0011145)3.50083640
22Dysostosis multiplex (HP:0000943)3.48498091
23Urinary glycosaminoglycan excretion (HP:0003541)3.42655465
24Mucopolysacchariduria (HP:0008155)3.42655465
25Pancreatitis (HP:0001733)3.39211459
26Abnormal protein glycosylation (HP:0012346)3.38518667
27Abnormal glycosylation (HP:0012345)3.38518667
28Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.38518667
29Abnormal protein N-linked glycosylation (HP:0012347)3.38518667
30Type I diabetes mellitus (HP:0100651)3.37939907
31Ketosis (HP:0001946)3.22929239
32Decreased subcutaneous fat (HP:0001002)3.20261080
33Colitis (HP:0002583)3.19279494
34Insulin-resistant diabetes mellitus (HP:0000831)3.11608073
35Abnormality of polysaccharide metabolism (HP:0011012)3.07553015
36Abnormality of glycosaminoglycan metabolism (HP:0004371)3.07553015
37Abnormality of mucopolysaccharide metabolism (HP:0011020)3.07553015
38Gastrointestinal stroma tumor (HP:0100723)3.01313011
39Late onset (HP:0003584)2.92902177
40Hyperglycemia (HP:0003074)2.87177220
41Thin bony cortex (HP:0002753)2.82156921
42Large for gestational age (HP:0001520)2.80455592
43Thoracolumbar scoliosis (HP:0002944)2.73009820
44Abnormality of the common coagulation pathway (HP:0010990)2.72905672
45Hyperacusis (HP:0010780)2.72569322
46Premature skin wrinkling (HP:0100678)2.70151900
47Abnormality of monocarboxylic acid metabolism (HP:0010996)2.67222901
48Short chin (HP:0000331)2.65661756
49Abdominal distention (HP:0003270)2.63842386
50Congenital glaucoma (HP:0001087)2.62660184
51Joint hemorrhage (HP:0005261)2.62455740
52Pancreatic islet-cell hyperplasia (HP:0004510)2.56459242
53Cellulitis (HP:0100658)2.55286113
54Cortical dysplasia (HP:0002539)2.53775517
55Reduced antithrombin III activity (HP:0001976)2.49974807
56Type I transferrin isoform profile (HP:0003642)2.49193631
57Agitation (HP:0000713)2.48545319
58Gastrointestinal inflammation (HP:0004386)2.46077982
59Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.46013547
60Maternal diabetes (HP:0009800)2.44647954
61Hypoproteinemia (HP:0003075)2.41447166
62Hyperphosphatemia (HP:0002905)2.41382943
63Fatigue (HP:0012378)2.40875995
64Hyperactive renin-angiotensin system (HP:0000841)2.37731702
65Prolonged partial thromboplastin time (HP:0003645)2.37131013
66Hypoplasia of the uterus (HP:0000013)2.34601722
67Abnormal tarsal ossification (HP:0008369)2.33817559
68Joint stiffness (HP:0001387)2.33412669
69Dysmetric saccades (HP:0000641)2.32747027
70Type II lissencephaly (HP:0007260)2.31463599
71Conjugated hyperbilirubinemia (HP:0002908)2.28317518
72Long toe (HP:0010511)2.27196953
73Rectal prolapse (HP:0002035)2.25892432
74Abnormality of the fingertips (HP:0001211)2.25563805
75Ankyloglossia (HP:0010296)2.24955260
76Myopathic facies (HP:0002058)2.21243104
77Generalized aminoaciduria (HP:0002909)2.20235937
78Long palpebral fissure (HP:0000637)2.19632143
79Abnormal foot bone ossification (HP:0010675)2.18278436
80Recurrent viral infections (HP:0004429)2.16374849
81Testicular atrophy (HP:0000029)2.16001984
82Severe short stature (HP:0003510)2.14420906
83Inflammation of the large intestine (HP:0002037)2.14068979
84Thoracic kyphosis (HP:0002942)2.13278632
85Broad face (HP:0000283)2.11985016
86Cortical visual impairment (HP:0100704)2.11962069
87Abnormality of aromatic amino acid family metabolism (HP:0004338)2.11215367
88Abnormality of the thoracic spine (HP:0100711)2.11204888
89Aplastic anemia (HP:0001915)2.11034198
90Squamous cell carcinoma (HP:0002860)2.09269362
91Long foot (HP:0001833)2.08972867
92Abnormality of the gastric mucosa (HP:0004295)2.07646154
93Intrahepatic cholestasis (HP:0001406)2.06719746
94Emphysema (HP:0002097)2.05834555
95Limb hypertonia (HP:0002509)2.05205649
96Poikiloderma (HP:0001029)2.05124263
97Abnormality of the Achilles tendon (HP:0005109)2.05103144
98Coxa valga (HP:0002673)2.04560828
99Progressive muscle weakness (HP:0003323)2.03959471
100Retinal atrophy (HP:0001105)2.03555725
101Right ventricular cardiomyopathy (HP:0011663)2.03196347
102Septate vagina (HP:0001153)2.02194142
103Agammaglobulinemia (HP:0004432)2.01783587
104Insulin resistance (HP:0000855)2.01638308
105Absent eyelashes (HP:0000561)2.01378005
106Eczematoid dermatitis (HP:0000976)2.01335681
107Decreased circulating renin level (HP:0003351)2.00664161
108Hypoplasia of the odontoid process (HP:0003311)1.99885328
109Abnormality of calcium-phosphate metabolism (HP:0100530)1.99864726
110Recurrent bronchitis (HP:0002837)1.99394219
111Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.98964618
112Elevated alkaline phosphatase (HP:0003155)1.98674040
113Hypotension (HP:0002615)1.98539389
114Abnormality of alkaline phosphatase activity (HP:0004379)1.98376316
115Abnormality of the lumbar spine (HP:0100712)1.98247969
116Shawl scrotum (HP:0000049)1.97909476
117Unilateral renal agenesis (HP:0000122)1.97258881
118Xanthomatosis (HP:0000991)1.96267992
119Asymmetry of the thorax (HP:0001555)1.96262760
120Tubulointerstitial nephritis (HP:0001970)1.95573933
121Ragged-red muscle fibers (HP:0003200)1.95376210
122Germ cell neoplasia (HP:0100728)1.95375424
123Vaginal fistula (HP:0004320)1.94813736
124Hypobetalipoproteinemia (HP:0003563)1.93864523
125IgA deficiency (HP:0002720)1.93526915
126Ulnar bowing (HP:0003031)1.92943163
127Barrel-shaped chest (HP:0001552)1.92885240
128Recurrent sinusitis (HP:0011108)1.92585705
129Achilles tendon contracture (HP:0001771)1.90611133
130Pectus carinatum (HP:0000768)1.89893227
131Abnormality of purine metabolism (HP:0004352)1.89382183
132Abnormal enzyme/coenzyme activity (HP:0012379)1.88481727
133Hyperparathyroidism (HP:0000843)1.88099278
134Cholecystitis (HP:0001082)1.88088378
135Abnormal gallbladder physiology (HP:0012438)1.88088378
136Cerebellar dysplasia (HP:0007033)1.87743179
137Abnormality of small intestinal villus morphology (HP:0011472)1.87053979
138Villous atrophy (HP:0011473)1.87053979
139IgM deficiency (HP:0002850)1.86035738
140Seborrheic dermatitis (HP:0001051)1.85400797
141Abnormality of complement system (HP:0005339)1.85236861
142Flattened epiphyses (HP:0003071)1.85024205
143Hepatitis (HP:0012115)1.84635782
144Malnutrition (HP:0004395)1.84533180
145Hypsarrhythmia (HP:0002521)1.84321799
146Meningitis (HP:0001287)1.84006974
147Hyponatremia (HP:0002902)1.83343441
148Macroorchidism (HP:0000053)1.82824933
149Testicular neoplasm (HP:0010788)1.82178052
150Cholelithiasis (HP:0001081)1.80786250
151EEG with generalized epileptiform discharges (HP:0011198)1.80054312
152Aplasia/hypoplasia of the uterus (HP:0008684)1.78856341
153Nephritis (HP:0000123)1.78466766
154Protuberant abdomen (HP:0001538)1.77009883
155Ridged nail (HP:0001807)1.76969281
156Micronodular cirrhosis (HP:0001413)1.76583571
157Abnormality of cells of the lymphoid lineage (HP:0012140)1.76138139
158Sparse lateral eyebrow (HP:0005338)1.75359950
159Amelogenesis imperfecta (HP:0000705)1.74264989
160Hypertensive crisis (HP:0100735)1.74047956
161Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.72707163
162Lower limb hyperreflexia (HP:0002395)1.71294925
163Premature loss of primary teeth (HP:0006323)1.69962034
164Widely patent fontanelles and sutures (HP:0004492)1.69655133
165Advanced eruption of teeth (HP:0006288)1.68494916
166Vasculitis (HP:0002633)1.67838878
167Abnormality of carpal bone ossification (HP:0006257)1.67043483
168Neonatal death (HP:0003811)1.66736557
169Delayed epiphyseal ossification (HP:0002663)1.66081265
17011 pairs of ribs (HP:0000878)1.65415981
171Abnormal hair laboratory examination (HP:0003328)1.64817226
172Death in childhood (HP:0003819)1.64730425
173Growth hormone excess (HP:0000845)1.64257909
174Recurrent otitis media (HP:0000403)1.64151038
175Progressive external ophthalmoplegia (HP:0000590)1.63888497
176Acute hepatic failure (HP:0006554)1.62432385
177Abnormality of the gallbladder (HP:0005264)1.62352394
178J-shaped sella turcica (HP:0002680)1.59582172
179Cheilitis (HP:0100825)1.58906683
180Urticaria (HP:0001025)1.58605111
181Trismus (HP:0000211)1.57896064
182Abnormality of the distal phalanx of the thumb (HP:0009617)1.57571455
183Facial hemangioma (HP:0000329)1.57200788

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.20675151
2ERN16.03803358
3TAOK35.35533151
4AKT34.04204551
5INSRR3.64581568
6SMG13.53812711
7PRPF4B3.49141614
8ICK3.11998340
9FRK3.03399868
10TRIB32.86417076
11EIF2AK32.83554306
12IRAK32.57641339
13MAP2K22.48242941
14EEF2K2.35421561
15FGFR42.31657714
16PKN22.30682900
17CDK122.25804771
18FLT32.14408738
19LATS12.13383299
20PASK1.93306641
21MAP3K21.85040242
22SIK11.81890417
23MAP4K11.70050559
24MAPKAPK31.68836903
25SCYL21.66641619
26PTK61.56165914
27PIK3CG1.32933922
28BLK1.31698239
29HIPK21.29347022
30WNK41.27564038
31TAOK11.27003384
32STK391.20624475
33MAP3K131.19011111
34RIPK41.15888344
35ARAF1.15002563
36LMTK21.13156767
37ZAP701.11397318
38PAK21.11329504
39PIK3CA1.09860576
40RPS6KB21.09564499
41MAP2K31.07270522
42TAOK21.05727671
43NME21.03969550
44PDGFRA1.00391375
45MET0.98819321
46KSR20.96868750
47TESK20.94896316
48MAP3K80.93916256
49TLK10.91947314
50MAPK110.89493554
51PDK20.88812370
52NTRK10.88174700
53IRAK40.86811468
54PRKCI0.86212027
55MAP3K110.82192909
56CDK70.81618486
57BRAF0.79259638
58PDGFRB0.78818102
59GRK60.77805496
60FER0.77574511
61JAK30.77488928
62PIM20.76790554
63CDK40.76023437
64MAP2K10.75988339
65MAPK150.75592806
66FGFR30.74332035
67MST40.71521605
68MARK20.71256532
69MTOR0.68706075
70RET0.67252893
71PTK20.65794944
72IRAK10.65259602
73NUAK10.64571741
74IRAK20.64304085
75PRKD30.63437989
76LRRK20.62454077
77MAP3K10.62267581
78MAP3K90.61435959
79MELK0.59588944
80MAP3K140.58549399
81PAK40.58101608
82EPHA30.55822790
83NEK60.54729532
84AURKA0.54341341
85TNK20.54216895
86MAP3K30.53789727
87CDC42BPA0.52621384
88JAK20.51801331
89IKBKE0.51162521
90STK40.49879361
91MYLK0.49645050
92RPS6KB10.49558474
93RAF10.46704436
94PRKCH0.46248330
95NEK90.45842140
96DYRK1A0.42457732
97CAMK1G0.40207752
98CAMKK10.40018817
99JAK10.39070897
100CAMK1D0.38100428
101CDK80.38068248
102SIK20.37920552
103RIPK10.37138721
104SGK30.36418990
105PRKD20.35908988
106PDPK10.35788700
107TYK20.35619688
108DYRK1B0.34787563
109CSF1R0.34626319
110RPS6KA20.34452303
111NME10.33812034
112AKT20.33661840
113CDK90.33247087
114MAP3K100.33189197
115MAP3K70.30005700
116CDK60.29995647
117TBK10.29407802
118RPS6KA50.29017099
119EIF2AK10.28844621
120PRKAA20.28762398
121LATS20.28385323
122PIM10.27006442
123PRKD10.26573146
124CHEK10.25917653
125PDK10.25423784
126EPHB10.24391219
127MAPKAPK20.23824963
128CAMKK20.23547775
129MAPK30.22600125
130MST1R0.22306245
131WNK10.22146593
132PRKAA10.21069450
133STK30.20735599
134EPHA20.20566745
135TRPM70.18459897
136IGF1R0.17740657
137GRK10.16447675
138MATK0.15655825
139EGFR0.15511739
140CHUK0.14066657
141PRKCE0.13693931
142AKT10.13664830
143CSNK1A10.13025802
144GSK3A0.11644850
145BTK0.10508102
146RPS6KA10.10332120
147PRKCZ0.07352135
148NTRK30.07294851
149MAPK140.07074561
150MAPK10.06294610

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030606.62993554
2Pancreatic secretion_Homo sapiens_hsa049725.96685771
3Protein processing in endoplasmic reticulum_Homo sapiens_hsa041414.49454876
4* Maturity onset diabetes of the young_Homo sapiens_hsa049504.48181906
5Fat digestion and absorption_Homo sapiens_hsa049753.91175201
6Protein digestion and absorption_Homo sapiens_hsa049743.89172850
7Fatty acid biosynthesis_Homo sapiens_hsa000613.20744069
8Sulfur metabolism_Homo sapiens_hsa009202.83730680
9N-Glycan biosynthesis_Homo sapiens_hsa005102.72150895
10Caffeine metabolism_Homo sapiens_hsa002322.29527046
11Systemic lupus erythematosus_Homo sapiens_hsa053222.13478051
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.13150281
13Folate biosynthesis_Homo sapiens_hsa007902.07145227
14Glycerolipid metabolism_Homo sapiens_hsa005611.83865058
15Other glycan degradation_Homo sapiens_hsa005111.81983779
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.76474575
17Arginine biosynthesis_Homo sapiens_hsa002201.69759387
18Cyanoamino acid metabolism_Homo sapiens_hsa004601.62601789
19Vibrio cholerae infection_Homo sapiens_hsa051101.62144844
20Insulin secretion_Homo sapiens_hsa049111.53307826
21Sulfur relay system_Homo sapiens_hsa041221.50871046
22B cell receptor signaling pathway_Homo sapiens_hsa046621.47884743
23Renin-angiotensin system_Homo sapiens_hsa046141.46483252
24Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.42200011
25Intestinal immune network for IgA production_Homo sapiens_hsa046721.39294112
26Selenocompound metabolism_Homo sapiens_hsa004501.37699982
27Phenylalanine metabolism_Homo sapiens_hsa003601.36945801
28Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.36569489
29Carbohydrate digestion and absorption_Homo sapiens_hsa049731.33903388
30Vitamin B6 metabolism_Homo sapiens_hsa007501.32397280
31Viral carcinogenesis_Homo sapiens_hsa052031.27828517
32Chronic myeloid leukemia_Homo sapiens_hsa052201.24465082
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.23405254
34Lysosome_Homo sapiens_hsa041421.19571068
35Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.18083017
36Alcoholism_Homo sapiens_hsa050341.17500287
37Propanoate metabolism_Homo sapiens_hsa006401.16936294
38Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.14529883
39Central carbon metabolism in cancer_Homo sapiens_hsa052301.10173656
40Pentose phosphate pathway_Homo sapiens_hsa000301.09728218
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.08000144
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.03689953
43Carbon metabolism_Homo sapiens_hsa012001.00463966
44Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.92754872
45Vitamin digestion and absorption_Homo sapiens_hsa049770.92066284
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.91286018
47Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.91180263
48Prion diseases_Homo sapiens_hsa050200.85466413
49Arginine and proline metabolism_Homo sapiens_hsa003300.84895794
50Toll-like receptor signaling pathway_Homo sapiens_hsa046200.82538770
51Type I diabetes mellitus_Homo sapiens_hsa049400.79181503
52Thyroid hormone synthesis_Homo sapiens_hsa049180.77357183
53Type II diabetes mellitus_Homo sapiens_hsa049300.76610959
54Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.73865858
55Apoptosis_Homo sapiens_hsa042100.72705130
56Drug metabolism - other enzymes_Homo sapiens_hsa009830.68396437
57alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.67823797
58Herpes simplex infection_Homo sapiens_hsa051680.67674699
59Insulin resistance_Homo sapiens_hsa049310.67388135
60Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.66359177
61DNA replication_Homo sapiens_hsa030300.65914616
62Glycosaminoglycan degradation_Homo sapiens_hsa005310.65529427
63Influenza A_Homo sapiens_hsa051640.65199631
64Bile secretion_Homo sapiens_hsa049760.64724266
65Hepatitis B_Homo sapiens_hsa051610.64599722
66Starch and sucrose metabolism_Homo sapiens_hsa005000.60965635
67Primary immunodeficiency_Homo sapiens_hsa053400.60687678
68Leishmaniasis_Homo sapiens_hsa051400.60645920
69Prostate cancer_Homo sapiens_hsa052150.59834301
70Legionellosis_Homo sapiens_hsa051340.59359103
71Prolactin signaling pathway_Homo sapiens_hsa049170.58275458
72Linoleic acid metabolism_Homo sapiens_hsa005910.57196188
73Galactose metabolism_Homo sapiens_hsa000520.57087006
74Fatty acid metabolism_Homo sapiens_hsa012120.56434161
75Endometrial cancer_Homo sapiens_hsa052130.55748844
76Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.54982661
77Adipocytokine signaling pathway_Homo sapiens_hsa049200.54309818
78PPAR signaling pathway_Homo sapiens_hsa033200.53838683
79NF-kappa B signaling pathway_Homo sapiens_hsa040640.53607953
80Fructose and mannose metabolism_Homo sapiens_hsa000510.52648132
81Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.52480371
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52135802
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51832476
84Measles_Homo sapiens_hsa051620.51444153
85Staphylococcus aureus infection_Homo sapiens_hsa051500.51089488
86Epstein-Barr virus infection_Homo sapiens_hsa051690.50343361
87mTOR signaling pathway_Homo sapiens_hsa041500.49794471
88HTLV-I infection_Homo sapiens_hsa051660.48090314
89Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.47810715
90Renal cell carcinoma_Homo sapiens_hsa052110.47431091
91One carbon pool by folate_Homo sapiens_hsa006700.47321354
92Notch signaling pathway_Homo sapiens_hsa043300.46433464
93Allograft rejection_Homo sapiens_hsa053300.44196981
94beta-Alanine metabolism_Homo sapiens_hsa004100.43375462
95Transcriptional misregulation in cancer_Homo sapiens_hsa052020.43231326
96Regulation of autophagy_Homo sapiens_hsa041400.42411742
97Complement and coagulation cascades_Homo sapiens_hsa046100.41894699
98Autoimmune thyroid disease_Homo sapiens_hsa053200.41875405
99Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41404689
100TNF signaling pathway_Homo sapiens_hsa046680.40843819
101Cocaine addiction_Homo sapiens_hsa050300.38193207
102Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37319642
103Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.35479923
104Estrogen signaling pathway_Homo sapiens_hsa049150.35254333
105Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.33642805
106Insulin signaling pathway_Homo sapiens_hsa049100.30107801
107Lysine degradation_Homo sapiens_hsa003100.30030968
108Pyruvate metabolism_Homo sapiens_hsa006200.28570213
109Tryptophan metabolism_Homo sapiens_hsa003800.27880923
110Biosynthesis of amino acids_Homo sapiens_hsa012300.26917787
111Hepatitis C_Homo sapiens_hsa051600.25301308
112Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.25299256
113Inositol phosphate metabolism_Homo sapiens_hsa005620.24547730
114Aldosterone synthesis and secretion_Homo sapiens_hsa049250.24281137
115Steroid biosynthesis_Homo sapiens_hsa001000.24211080
116Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.24112092
117Fatty acid degradation_Homo sapiens_hsa000710.23943276
118Cysteine and methionine metabolism_Homo sapiens_hsa002700.23789769
119Salivary secretion_Homo sapiens_hsa049700.23341032
120Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.23149929
1212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.22836411
122AMPK signaling pathway_Homo sapiens_hsa041520.21766247
123Bladder cancer_Homo sapiens_hsa052190.21665413
124Pancreatic cancer_Homo sapiens_hsa052120.21146152
125Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.20661467
126Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.19441594
127Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.19014707
128Vascular smooth muscle contraction_Homo sapiens_hsa042700.18633872
129Acute myeloid leukemia_Homo sapiens_hsa052210.18520863
130Neurotrophin signaling pathway_Homo sapiens_hsa047220.16811065
131Toxoplasmosis_Homo sapiens_hsa051450.16484263
132Glucagon signaling pathway_Homo sapiens_hsa049220.15581697
133ABC transporters_Homo sapiens_hsa020100.15064231
134Non-small cell lung cancer_Homo sapiens_hsa052230.14281342
135Histidine metabolism_Homo sapiens_hsa003400.13450356
136Thyroid cancer_Homo sapiens_hsa052160.13175083
137Gastric acid secretion_Homo sapiens_hsa049710.12650000
138Metabolic pathways_Homo sapiens_hsa011000.12473495
139Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.10855642
140Antigen processing and presentation_Homo sapiens_hsa046120.10366256
141Phosphatidylinositol signaling system_Homo sapiens_hsa040700.10351127
142Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.09151148
143Taste transduction_Homo sapiens_hsa047420.08369671
144Tight junction_Homo sapiens_hsa045300.07840447
145VEGF signaling pathway_Homo sapiens_hsa043700.07799502

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »