BFAR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)7.11957558
2regulation of antigen processing and presentation of peptide antigen (GO:0002583)6.51724139
3antigen processing and presentation via MHC class Ib (GO:0002475)6.34006868
4establishment of protein localization to mitochondrial membrane (GO:0090151)5.45328842
5nuclear envelope reassembly (GO:0031468)5.28935573
6mitotic nuclear envelope reassembly (GO:0007084)5.28935573
7ribosomal small subunit assembly (GO:0000028)4.92445607
8peptidyl-lysine dimethylation (GO:0018027)4.83028108
9negative regulation of catenin import into nucleus (GO:0035414)4.43385504
10ribosomal small subunit biogenesis (GO:0042274)4.33345782
11platelet dense granule organization (GO:0060155)3.87785432
12antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.80211845
13proline biosynthetic process (GO:0006561)3.70794268
14rRNA modification (GO:0000154)3.60212126
15ribonucleoprotein complex biogenesis (GO:0022613)3.53795162
16rRNA methylation (GO:0031167)3.50397898
17ribosome biogenesis (GO:0042254)3.41798784
18ribosomal large subunit biogenesis (GO:0042273)3.39588603
19mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.37243753
20presynaptic membrane assembly (GO:0097105)3.35682140
21SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.32285942
22negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.32134491
23cotranslational protein targeting to membrane (GO:0006613)3.25926542
24ribosome assembly (GO:0042255)3.24680427
25viral transcription (GO:0019083)3.23885067
26protein targeting to ER (GO:0045047)3.23705775
27L-phenylalanine catabolic process (GO:0006559)3.21395233
28erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.21395233
29regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.20070104
30regulation of sister chromatid cohesion (GO:0007063)3.18968927
31determination of adult lifespan (GO:0008340)3.17855732
32translational termination (GO:0006415)3.17815527
33establishment of integrated proviral latency (GO:0075713)3.15338107
34positive regulation of chromosome segregation (GO:0051984)3.11425357
35positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.10974265
36establishment of protein localization to endoplasmic reticulum (GO:0072599)3.10289529
37positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.09993512
38positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.09993512
39positive regulation of mitotic sister chromatid separation (GO:1901970)3.09993512
40anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.06004664
41negative regulation of ligase activity (GO:0051352)3.04191496
42negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.04191496
43opsonization (GO:0008228)3.03708378
44transcription elongation from RNA polymerase III promoter (GO:0006385)3.01682722
45termination of RNA polymerase III transcription (GO:0006386)3.01682722
46protein localization to endoplasmic reticulum (GO:0070972)3.00043479
47translational elongation (GO:0006414)2.94357095
48cellular component biogenesis (GO:0044085)2.93822132
49mitotic nuclear envelope disassembly (GO:0007077)2.92817706
50aromatic amino acid family catabolic process (GO:0009074)2.92287155
51regulation of cellular amino acid metabolic process (GO:0006521)2.91325600
52negative regulation of granulocyte differentiation (GO:0030853)2.90774887
53translational initiation (GO:0006413)2.89765098
54positive regulation of protein kinase C signaling (GO:0090037)2.89502556
55positive regulation of antigen processing and presentation (GO:0002579)2.82566662
56translation (GO:0006412)2.81167340
57prenylation (GO:0097354)2.79906757
58protein prenylation (GO:0018342)2.79906757
59erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.77860150
60L-phenylalanine metabolic process (GO:0006558)2.77860150
61fatty acid elongation (GO:0030497)2.77587990
62intracellular transport of virus (GO:0075733)2.76883943
63multi-organism transport (GO:0044766)2.76883943
64multi-organism localization (GO:1902579)2.76883943
65multi-organism intracellular transport (GO:1902583)2.76883943
66transport of virus (GO:0046794)2.76883943
67presynaptic membrane organization (GO:0097090)2.76881191
68DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.75863473
69signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.75394068
70signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.75394068
71signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.75394068
72antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.74252403
73signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.73363707
74intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.73363707
75indole-containing compound catabolic process (GO:0042436)2.73348432
76indolalkylamine catabolic process (GO:0046218)2.73348432
77tryptophan catabolic process (GO:0006569)2.73348432
78maturation of SSU-rRNA (GO:0030490)2.72550923
79regulation of activation of Janus kinase activity (GO:0010533)2.72505336
80positive regulation of protein export from nucleus (GO:0046827)2.72211217
81transcription elongation from RNA polymerase II promoter (GO:0006368)2.70312646
82antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.69360761
83coenzyme catabolic process (GO:0009109)2.68284453
84chromatin remodeling at centromere (GO:0031055)2.67843223
85signal transduction involved in DNA integrity checkpoint (GO:0072401)2.67665021
86signal transduction involved in DNA damage checkpoint (GO:0072422)2.67665021
87neuron remodeling (GO:0016322)2.66577129
88positive regulation of cellular amine metabolic process (GO:0033240)2.65385455
89proline metabolic process (GO:0006560)2.65119888
90CENP-A containing nucleosome assembly (GO:0034080)2.64321930
91positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.64139380
92regulation of catenin import into nucleus (GO:0035412)2.63389785
93nuclear envelope disassembly (GO:0051081)2.63325904
94membrane disassembly (GO:0030397)2.63325904
95mitotic metaphase plate congression (GO:0007080)2.62926987
96signal transduction involved in cell cycle checkpoint (GO:0072395)2.62662694
97superoxide anion generation (GO:0042554)2.61776081
98response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.60827043
99axon ensheathment in central nervous system (GO:0032291)2.60797542
100central nervous system myelination (GO:0022010)2.60797542
101tryptophan metabolic process (GO:0006568)2.59672708
102nucleotide transmembrane transport (GO:1901679)2.57538629
103mesenchymal cell differentiation involved in kidney development (GO:0072161)2.56829987
104mesenchymal cell differentiation involved in renal system development (GO:2001012)2.56829987
105neuron cell-cell adhesion (GO:0007158)2.56762356
106regulation of mitotic metaphase/anaphase transition (GO:0030071)2.56594731
107regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.56594731
108tRNA aminoacylation for protein translation (GO:0006418)2.56121739
109paraxial mesoderm development (GO:0048339)2.56018108
110respiratory electron transport chain (GO:0022904)2.54949283
111cellular response to interferon-beta (GO:0035458)2.54837351
112formation of translation preinitiation complex (GO:0001731)2.54776595
113cellular biogenic amine catabolic process (GO:0042402)2.54584533
114amine catabolic process (GO:0009310)2.54584533
115mitotic spindle checkpoint (GO:0071174)2.53985331
116tRNA aminoacylation (GO:0043039)2.53297132
117amino acid activation (GO:0043038)2.53297132
118spindle checkpoint (GO:0031577)2.52101205
119negative regulation of chromosome segregation (GO:0051985)2.51891995
120negative regulation of mitotic sister chromatid separation (GO:2000816)2.51860401
121negative regulation of sister chromatid segregation (GO:0033046)2.51860401
122negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.51860401
123negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.51860401
124negative regulation of mitotic sister chromatid segregation (GO:0033048)2.51860401
125nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.50769154
126nucleotide-sugar biosynthetic process (GO:0009226)2.50042468
127positive regulation of ligase activity (GO:0051351)2.49804102
128regulation of mitotic sister chromatid segregation (GO:0033047)2.49722588
129regulation of sister chromatid segregation (GO:0033045)2.49722588
130cofactor catabolic process (GO:0051187)2.48858996
131opioid receptor signaling pathway (GO:0038003)2.48198138
132blood coagulation, intrinsic pathway (GO:0007597)2.47075629
133electron transport chain (GO:0022900)2.46750030
134ATP synthesis coupled proton transport (GO:0015986)2.46027658
135energy coupled proton transport, down electrochemical gradient (GO:0015985)2.46027658
136positive regulation of action potential (GO:0045760)2.44934745
137NAD biosynthetic process (GO:0009435)2.40167009
138negative regulation of synaptic transmission, GABAergic (GO:0032229)2.37981109
139T-helper 1 type immune response (GO:0042088)2.37827777
140aldehyde catabolic process (GO:0046185)2.37681197
141indolalkylamine metabolic process (GO:0006586)2.36340808
142intracellular pH reduction (GO:0051452)2.34976028
143response to interferon-beta (GO:0035456)2.33934076
144polyketide metabolic process (GO:0030638)2.32229584
145doxorubicin metabolic process (GO:0044598)2.32229584
146daunorubicin metabolic process (GO:0044597)2.32229584
147triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.31920010
148mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.31737458
149alkaloid metabolic process (GO:0009820)2.29356784
150adenosine metabolic process (GO:0046085)2.27909429
151limb bud formation (GO:0060174)2.27565668
152respiratory chain complex IV assembly (GO:0008535)2.23715680
153regulation of T-helper 1 cell differentiation (GO:0045625)2.23121237
154bile acid biosynthetic process (GO:0006699)2.21995053
155cellular ketone body metabolic process (GO:0046950)2.20214889
156cerebral cortex radially oriented cell migration (GO:0021799)2.18653121
157kynurenine metabolic process (GO:0070189)2.17780361
158glycerophospholipid catabolic process (GO:0046475)2.17522009
159regulation of interleukin-8 secretion (GO:2000482)2.16659955
160postsynaptic membrane organization (GO:0001941)2.16328759
161dopamine transport (GO:0015872)2.14956857
162positive regulation of acute inflammatory response (GO:0002675)2.14685636
163regulation of memory T cell differentiation (GO:0043380)2.14544107
164regulation of fibrinolysis (GO:0051917)2.14249189
165import into cell (GO:0098657)2.13629406
166tyrosine metabolic process (GO:0006570)2.12836792
167respiratory burst (GO:0045730)2.11030345
168positive regulation of toll-like receptor signaling pathway (GO:0034123)2.10247391
169regulation of cholesterol esterification (GO:0010872)2.09137723
170low-density lipoprotein particle remodeling (GO:0034374)2.08563887
171aromatic amino acid family metabolic process (GO:0009072)2.08166021
172regulation of triglyceride catabolic process (GO:0010896)2.07794776
173short-term memory (GO:0007614)2.07443753
174lymphoid progenitor cell differentiation (GO:0002320)2.07323656
175positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.07254977
176phospholipid efflux (GO:0033700)2.05511638
177negative regulation of lipase activity (GO:0060192)2.05307629
178glyoxylate metabolic process (GO:0046487)2.03767078
179dopamine biosynthetic process (GO:0042416)2.02630882
180activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.02351655
181DNA strand renaturation (GO:0000733)10.0921149
182protein carboxylation (GO:0018214)1.99943737
183peptidyl-glutamic acid carboxylation (GO:0017187)1.99943737
184fibrinolysis (GO:0042730)1.99724253
185high-density lipoprotein particle remodeling (GO:0034375)1.97386189
186negative regulation of protein localization to cell surface (GO:2000009)1.95490522
187behavioral response to nicotine (GO:0035095)1.95409985
188righting reflex (GO:0060013)1.94810057
189negative regulation of neurotransmitter transport (GO:0051589)1.94674380
190cholesterol efflux (GO:0033344)1.94397580
191cellular response to exogenous dsRNA (GO:0071360)1.94285153
192pH reduction (GO:0045851)1.93856846
193uronic acid metabolic process (GO:0006063)1.92943800
194glucuronate metabolic process (GO:0019585)1.92943800
195plasma lipoprotein particle remodeling (GO:0034369)1.92901009
196protein-lipid complex remodeling (GO:0034368)1.92901009
197macromolecular complex remodeling (GO:0034367)1.92901009
198regulation of acute inflammatory response to antigenic stimulus (GO:0002864)1.92213002
199very long-chain fatty acid metabolic process (GO:0000038)1.90616949

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.46189497
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.25612786
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.23718815
4* GABP_17652178_ChIP-ChIP_JURKAT_Human3.93203297
5GBX2_23144817_ChIP-Seq_PC3_Human3.17396346
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.17069458
7TAF15_26573619_Chip-Seq_HEK293_Human2.95000137
8CREB1_15753290_ChIP-ChIP_HEK293T_Human2.87365616
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.85970689
10* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.85334321
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.76813329
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.73148965
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.70751930
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.69978595
15* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.61387055
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.57535615
17EZH2_22144423_ChIP-Seq_EOC_Human2.54757511
18* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.54545288
19ZFP57_27257070_Chip-Seq_ESCs_Mouse2.51060724
20* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.46341839
21ELK1_19687146_ChIP-ChIP_HELA_Human2.44841640
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.40266436
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.39972827
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.38639823
25AR_21909140_ChIP-Seq_LNCAP_Human2.17289138
26EGR1_23403033_ChIP-Seq_LIVER_Mouse2.12293238
27POU3F2_20337985_ChIP-ChIP_501MEL_Human2.10434522
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.08732707
29E2F1_18555785_ChIP-Seq_MESCs_Mouse2.06714693
30VDR_22108803_ChIP-Seq_LS180_Human2.05865104
31* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.04351463
32JARID2_20064375_ChIP-Seq_MESCs_Mouse2.02988408
33SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.99419721
34EED_16625203_ChIP-ChIP_MESCs_Mouse1.98971718
35IRF8_22096565_ChIP-ChIP_GC-B_Human1.98573447
36FOXM1_23109430_ChIP-Seq_U2OS_Human1.94556162
37* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.94380926
38HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.92781913
39SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.91980207
40SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.91467389
41DCP1A_22483619_ChIP-Seq_HELA_Human1.88986059
42BP1_19119308_ChIP-ChIP_Hs578T_Human1.85865497
43TTF2_22483619_ChIP-Seq_HELA_Human1.85695153
44PCGF2_27294783_Chip-Seq_ESCs_Mouse1.85661269
45SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.84662449
46THAP11_20581084_ChIP-Seq_MESCs_Mouse1.84200507
47IGF1R_20145208_ChIP-Seq_DFB_Human1.84024199
48P300_19829295_ChIP-Seq_ESCs_Human1.83829511
49MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.80877847
50BMI1_23680149_ChIP-Seq_NPCS_Mouse1.79824375
51FOXP3_21729870_ChIP-Seq_TREG_Human1.78896563
52CDX2_19796622_ChIP-Seq_MESCs_Mouse1.77728421
53EZH2_27304074_Chip-Seq_ESCs_Mouse1.76951828
54CBX2_27304074_Chip-Seq_ESCs_Mouse1.76885172
55SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.73143779
56IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.72143265
57PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.70627449
58FLI1_27457419_Chip-Seq_LIVER_Mouse1.69764724
59NANOG_18555785_ChIP-Seq_MESCs_Mouse1.69403803
60ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.68832280
61NOTCH1_21737748_ChIP-Seq_TLL_Human1.67651134
62VDR_23849224_ChIP-Seq_CD4+_Human1.66191987
63SUZ12_27294783_Chip-Seq_NPCs_Mouse1.65965092
64CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.65200791
65TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.64982057
66ESR1_15608294_ChIP-ChIP_MCF-7_Human1.64326914
67XRN2_22483619_ChIP-Seq_HELA_Human1.63011245
68ER_23166858_ChIP-Seq_MCF-7_Human1.62975650
69YY1_21170310_ChIP-Seq_MESCs_Mouse1.61871688
70FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.61817541
71PCGF2_27294783_Chip-Seq_NPCs_Mouse1.61487069
72SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.60344563
73POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.60316570
74IRF8_21731497_ChIP-ChIP_J774_Mouse1.60100915
75CTBP2_25329375_ChIP-Seq_LNCAP_Human1.59731262
76POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.59718165
77NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.59494978
78ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.59217420
79MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.58463890
80GABP_19822575_ChIP-Seq_HepG2_Human1.58378835
81JARID2_20075857_ChIP-Seq_MESCs_Mouse1.58031848
82PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.56642769
83* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56356804
84MYCN_18555785_ChIP-Seq_MESCs_Mouse1.55652441
85AR_21572438_ChIP-Seq_LNCaP_Human1.55124900
86NFE2_27457419_Chip-Seq_LIVER_Mouse1.53790255
87KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.52770271
88KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.52770271
89KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.52770271
90EZH2_18974828_ChIP-Seq_MESCs_Mouse1.52456185
91RNF2_18974828_ChIP-Seq_MESCs_Mouse1.52456185
92EZH2_27294783_Chip-Seq_NPCs_Mouse1.52329654
93SOX17_20123909_ChIP-Seq_XEN_Mouse1.51719807
94YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.51676375
95EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.50460111
96CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48664635
97MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.47483166
98SRF_21415370_ChIP-Seq_HL-1_Mouse1.47131346
99PIAS1_25552417_ChIP-Seq_VCAP_Human1.44908460
100KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.44451073
101NANOG_18555785_Chip-Seq_ESCs_Mouse1.43623242
102SUZ12_18555785_Chip-Seq_ESCs_Mouse1.42730759
103ZFX_18555785_ChIP-Seq_MESCs_Mouse1.41685394
104NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.40188566
105MTF2_20144788_ChIP-Seq_MESCs_Mouse1.39238562
106TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.39188150
107EZH2_27294783_Chip-Seq_ESCs_Mouse1.38528924
108EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.37938107
109P53_22387025_ChIP-Seq_ESCs_Mouse1.37284071
110RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.37009950
111SUZ12_27294783_Chip-Seq_ESCs_Mouse1.36790085
112TP53_18474530_ChIP-ChIP_U2OS_Human1.35871860
113PADI4_21655091_ChIP-ChIP_MCF-7_Human1.35655252
114UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.34706882
115SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.34114295
116SMAD_19615063_ChIP-ChIP_OVARY_Human1.34006016
117E2F1_18555785_Chip-Seq_ESCs_Mouse1.33877957
118FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.32501756
119RUNX1_27457419_Chip-Seq_LIVER_Mouse1.32442835
120SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31903699
121E2F1_21310950_ChIP-Seq_MCF-7_Human1.30089744
122SMAD4_21799915_ChIP-Seq_A2780_Human1.29807256
123STAT3_18555785_Chip-Seq_ESCs_Mouse1.29712144
124CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.29703412
125SMAD3_21741376_ChIP-Seq_EPCs_Human1.28666870
126FUS_26573619_Chip-Seq_HEK293_Human1.28663388
127CMYC_18555785_Chip-Seq_ESCs_Mouse1.27229497
128HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.26909058
129OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25216897
130P300_18555785_Chip-Seq_ESCs_Mouse1.24750585
131E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.24663398
132PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.23851965
133TFEB_21752829_ChIP-Seq_HELA_Human1.22873983
134IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.22853093
135CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.22139222
136HTT_18923047_ChIP-ChIP_STHdh_Human1.21873070
137HOXB4_20404135_ChIP-ChIP_EML_Mouse1.21793916
138ZNF263_19887448_ChIP-Seq_K562_Human1.21464209
139POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.20611010
140ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.20514573
141NMYC_18555785_Chip-Seq_ESCs_Mouse1.19244082
142NANOG_16153702_ChIP-ChIP_HESCs_Human1.18500904
143RXR_22158963_ChIP-Seq_LIVER_Mouse1.17328358
144PU1_27457419_Chip-Seq_LIVER_Mouse1.17272473
145SOX2_18555785_Chip-Seq_ESCs_Mouse1.16970205
146ELK1_22589737_ChIP-Seq_MCF10A_Human1.16645206
147SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.15441061
148RNF2_27304074_Chip-Seq_NSC_Mouse1.14856027
149ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.14556643
150CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.14424568
151TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14028662
152TRIM28_21343339_ChIP-Seq_HEK293_Human1.13957755
153ZFX_18555785_Chip-Seq_ESCs_Mouse1.13384379
154CRX_20693478_ChIP-Seq_RETINA_Mouse1.13107448
155OCT4_18555785_Chip-Seq_ESCs_Mouse1.12640637
156TCF3_18692474_ChIP-Seq_MEFs_Mouse1.12190231
157FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.11938501
158TAL1_26923725_Chip-Seq_HPCs_Mouse1.11276861
159Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.11256054
160RNF2_27304074_Chip-Seq_ESCs_Mouse1.10477986
161PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.10293030
162NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.09962654
163NRF2_20460467_ChIP-Seq_MEFs_Mouse1.09962654
164SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.09397926
165CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.09293295
166SMAD1_18555785_Chip-Seq_ESCs_Mouse1.08659787
167* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.08357773
168BCAT_22108803_ChIP-Seq_LS180_Human1.07097536
169KLF4_18555785_Chip-Seq_ESCs_Mouse1.06905052
170OCT4_21477851_ChIP-Seq_ESCs_Mouse1.06764964
171WT1_19549856_ChIP-ChIP_CCG9911_Human1.06077329
172CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.06036230
173SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.05877535
174STAT3_1855785_ChIP-Seq_MESCs_Mouse1.05500061
175KDM2B_26808549_Chip-Seq_REH_Human1.03938500
176MYC_18940864_ChIP-ChIP_HL60_Human0.98770753
177RBPJ_22232070_ChIP-Seq_NCS_Mouse0.92117982
178SOX2_18555785_ChIP-Seq_MESCs_Mouse0.90978967
179TP63_17297297_ChIP-ChIP_HaCaT_Human0.90581208
180SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.90579833
181CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.88731083
182BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.88552228
183PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.88542586
184KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.88463978
185SALL1_21062744_ChIP-ChIP_HESCs_Human0.85443369
186POU5F1_16153702_ChIP-ChIP_HESCs_Human0.85269126
187NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.84797514
188EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.83883044
189CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.79674026
190TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.79378920
191CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.79335545
192HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.79139555
193SOX2_18692474_ChIP-Seq_MEFs_Mouse0.77822302
194KDM5A_27292631_Chip-Seq_BREAST_Human0.76854997

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003878_abnormal_ear_physiology3.73419842
2MP0005377_hearing/vestibular/ear_phenot3.73419842
3MP0008438_abnormal_cutaneous_collagen3.53352045
4MP0003724_increased_susceptibility_to3.41888836
5MP0003111_abnormal_nucleus_morphology3.16109236
6MP0003941_abnormal_skin_development3.05104611
7MP0003880_abnormal_central_pattern2.96995173
8MP0003693_abnormal_embryo_hatching2.86183281
9MP0002139_abnormal_hepatobiliary_system2.83594588
10MP0004272_abnormal_basement_membrane2.81924335
11MP0004957_abnormal_blastocyst_morpholog2.79555724
12MP0010030_abnormal_orbit_morphology2.75309260
13MP0005408_hypopigmentation2.52578653
14MP0005085_abnormal_gallbladder_physiolo2.41934763
15MP0002938_white_spotting2.36739404
16MP0005379_endocrine/exocrine_gland_phen2.33505098
17MP0005360_urolithiasis2.22774446
18MP0000372_irregular_coat_pigmentation2.21819368
19MP0003950_abnormal_plasma_membrane2.17747416
20MP0008932_abnormal_embryonic_tissue2.17152193
21MP0003937_abnormal_limbs/digits/tail_de2.14505558
22MP0005257_abnormal_intraocular_pressure2.10545695
23MP0003195_calcinosis2.07386875
24MP0005365_abnormal_bile_salt2.01186646
25MP0001835_abnormal_antigen_presentation1.99209494
26MP0004381_abnormal_hair_follicle1.96663134
27MP0008875_abnormal_xenobiotic_pharmacok1.95906397
28MP0003136_yellow_coat_color1.95315481
29MP0001346_abnormal_lacrimal_gland1.94791844
30MP0006276_abnormal_autonomic_nervous1.93264180
31MP0002148_abnormal_hypersensitivity_rea1.92601654
32MP0003718_maternal_effect1.87644346
33MP0002876_abnormal_thyroid_physiology1.83764886
34MP0010368_abnormal_lymphatic_system1.79241873
35MP0000566_synostosis1.76903565
36MP0003077_abnormal_cell_cycle1.75862637
37MP0005451_abnormal_body_composition1.71615254
38MP0004142_abnormal_muscle_tone1.70553335
39MP0009785_altered_susceptibility_to1.69858064
40MP0002163_abnormal_gland_morphology1.69743708
41MP0001188_hyperpigmentation1.65845939
42MP0005409_darkened_coat_color1.65340657
43MP0010094_abnormal_chromosome_stability1.63957322
44MP0004742_abnormal_vestibular_system1.63170136
45MP0000350_abnormal_cell_proliferation1.59209269
46MP0001905_abnormal_dopamine_level1.57193110
47MP0003890_abnormal_embryonic-extraembry1.56037195
48MP0002102_abnormal_ear_morphology1.54470015
49MP0002166_altered_tumor_susceptibility1.54294472
50MP0002277_abnormal_respiratory_mucosa1.53782741
51MP0001529_abnormal_vocalization1.51278055
52MP0002837_dystrophic_cardiac_calcinosis1.50477696
53MP0008058_abnormal_DNA_repair1.49532230
54MP0001986_abnormal_taste_sensitivity1.48744429
55MP0009250_abnormal_appendicular_skeleto1.47893311
56MP0002006_tumorigenesis1.43225627
57MP0001293_anophthalmia1.40861520
58MP0001730_embryonic_growth_arrest1.40779775
59MP0009379_abnormal_foot_pigmentation1.39574846
60MP0002638_abnormal_pupillary_reflex1.37788428
61MP0005671_abnormal_response_to1.36149340
62MP0001790_abnormal_immune_system1.34656776
63MP0005387_immune_system_phenotype1.34656776
64MP0005551_abnormal_eye_electrophysiolog1.34600241
65MP0002419_abnormal_innate_immunity1.32378222
66MP0005000_abnormal_immune_tolerance1.32179153
67MP0001486_abnormal_startle_reflex1.31282829
68MP0003123_paternal_imprinting1.30777733
69MP0006082_CNS_inflammation1.27214210
70MP0010352_gastrointestinal_tract_polyps1.26997508
71MP0009764_decreased_sensitivity_to1.26282401
72MP0001501_abnormal_sleep_pattern1.26281814
73MP0000920_abnormal_myelination1.25808188
74MP0003315_abnormal_perineum_morphology1.23211145
75MP0008004_abnormal_stomach_pH1.22277283
76MP0002085_abnormal_embryonic_tissue1.21895082
77MP0003690_abnormal_glial_cell1.21735731
78MP0010386_abnormal_urinary_bladder1.21460488
79MP0003567_abnormal_fetal_cardiomyocyte1.19914180
80MP0009745_abnormal_behavioral_response1.19652210
81MP0003868_abnormal_feces_composition1.19482082
82MP0005535_abnormal_body_temperature1.19145958
83MP0005197_abnormal_uvea_morphology1.18379379
84MP0005025_abnormal_response_to1.18333740
85MP0002697_abnormal_eye_size1.15283143
86MP0010329_abnormal_lipoprotein_level1.14492591
87MP0000762_abnormal_tongue_morphology1.14077296
88MP0005275_abnormal_skin_tensile1.13911081
89MP0001440_abnormal_grooming_behavior1.13277593
90MP0001672_abnormal_embryogenesis/_devel1.13163791
91MP0005380_embryogenesis_phenotype1.13163791
92MP0003122_maternal_imprinting1.11779035
93MP0009046_muscle_twitch1.11238533
94MP0002064_seizures1.11153630
95MP0005423_abnormal_somatic_nervous1.11105332
96MP0001984_abnormal_olfaction1.11042894
97MP0002084_abnormal_developmental_patter1.10794846
98MP0003436_decreased_susceptibility_to1.10490726
99MP0002254_reproductive_system_inflammat1.09576450
100MP0002272_abnormal_nervous_system1.09059895
101MP0004134_abnormal_chest_morphology1.08344216
102MP0002086_abnormal_extraembryonic_tissu1.07990183
103MP0002736_abnormal_nociception_after1.07125394
104MP0009384_cardiac_valve_regurgitation1.07067072
105MP0005083_abnormal_biliary_tract1.06344858
106MP0001661_extended_life_span1.05924486
107MP0002088_abnormal_embryonic_growth/wei1.05326882
108MP0001968_abnormal_touch/_nociception1.05321937
109MP0001697_abnormal_embryo_size1.05168853
110MP0001286_abnormal_eye_development1.04438437
111MP0005645_abnormal_hypothalamus_physiol1.03866763
112MP0003984_embryonic_growth_retardation1.03266038
113MP0004019_abnormal_vitamin_homeostasis1.02428708
114MP0003566_abnormal_cell_adhesion1.02274895
115MP0008007_abnormal_cellular_replicative1.02176026
116MP0001666_abnormal_nutrient_absorption1.02052994
117MP0006292_abnormal_olfactory_placode1.00873481
118MP0005646_abnormal_pituitary_gland1.00726121
119MP0002067_abnormal_sensory_capabilities1.00612768
120MP0004510_myositis1.00129305
121MP0009672_abnormal_birth_weight0.99992575
122MP0003942_abnormal_urinary_system0.98941579
123MP0000358_abnormal_cell_content/0.98558699
124MP0005332_abnormal_amino_acid0.97031272
125MP0003806_abnormal_nucleotide_metabolis0.96816562
126MP0005171_absent_coat_pigmentation0.93675260
127MP0002971_abnormal_brown_adipose0.93166516
128MP0006054_spinal_hemorrhage0.91826583
129MP0005595_abnormal_vascular_smooth0.91784694
130MP0008469_abnormal_protein_level0.90799717
131MP0005164_abnormal_response_to0.90661051
132MP0003191_abnormal_cellular_cholesterol0.89815041
133MP0002080_prenatal_lethality0.89168338
134MP0009697_abnormal_copulation0.88906374
135MP0010307_abnormal_tumor_latency0.88378246
136MP0001764_abnormal_homeostasis0.88045160
137MP0003011_delayed_dark_adaptation0.88037911
138MP0002735_abnormal_chemical_nociception0.88007965
139MP0002118_abnormal_lipid_homeostasis0.87757895
140MP0002723_abnormal_immune_serum0.87476472
141MP0002751_abnormal_autonomic_nervous0.86476869
142MP0005670_abnormal_white_adipose0.86318483
143MP0008057_abnormal_DNA_replication0.84261729
144MP0005084_abnormal_gallbladder_morpholo0.83698606
145MP0002572_abnormal_emotion/affect_behav0.83555719
146MP0005464_abnormal_platelet_physiology0.83328605
147MP0001324_abnormal_eye_pigmentation0.83034109
148MP0003186_abnormal_redox_activity0.82837770
149MP0002233_abnormal_nose_morphology0.82761762
150MP0004782_abnormal_surfactant_physiolog0.82550801
151MP0001800_abnormal_humoral_immune0.82470231
152MP0000015_abnormal_ear_pigmentation0.81594225
153MP0005389_reproductive_system_phenotype0.81379086
154MP0002933_joint_inflammation0.81323226
155MP0003705_abnormal_hypodermis_morpholog0.81312636
156MP0002295_abnormal_pulmonary_circulatio0.81275467
157MP0001119_abnormal_female_reproductive0.81183920
158MP0005174_abnormal_tail_pigmentation0.80818387
159MP0009763_increased_sensitivity_to0.79522447
160MP0005248_abnormal_Harderian_gland0.78613603
161MP0000026_abnormal_inner_ear0.78309894
162MP0002452_abnormal_antigen_presenting0.76461949
163MP0004233_abnormal_muscle_weight0.76428590
164MP0003879_abnormal_hair_cell0.76241018
165MP0003283_abnormal_digestive_organ0.76194305
166MP0005165_increased_susceptibility_to0.75291173
167MP0008874_decreased_physiological_sensi0.74797453
168MP0005584_abnormal_enzyme/coenzyme_acti0.74633738
169MP0000579_abnormal_nail_morphology0.74223893
170MP0001533_abnormal_skeleton_physiology0.73821702
171MP0002060_abnormal_skin_morphology0.73644094
172MP0001915_intracranial_hemorrhage0.71463379
173MP0002210_abnormal_sex_determination0.70799150
174MP0005623_abnormal_meninges_morphology0.70414819
175MP0000432_abnormal_head_morphology0.69991001
176MP0003755_abnormal_palate_morphology0.69143636
177MP0001919_abnormal_reproductive_system0.68240502
178MP0003935_abnormal_craniofacial_develop0.67841653
179MP0002160_abnormal_reproductive_system0.67032795
180MP0005023_abnormal_wound_healing0.64523322
181MP0001299_abnormal_eye_distance/0.64508841
182MP0000647_abnormal_sebaceous_gland0.62616324
183MP0005075_abnormal_melanosome_morpholog0.62245374
184MP0000627_abnormal_mammary_gland0.62231123
185MP0001881_abnormal_mammary_gland0.61616428

Predicted human phenotypes

RankGene SetZ-score
1Chronic otitis media (HP:0000389)6.15305715
2Reduced subcutaneous adipose tissue (HP:0003758)4.63779565
3Muscle fiber atrophy (HP:0100295)4.34364614
4Achilles tendon contracture (HP:0001771)4.26434397
5Shawl scrotum (HP:0000049)4.19066948
6Prolonged partial thromboplastin time (HP:0003645)4.15657244
7Large eyes (HP:0001090)4.12814089
8Abnormality of the Achilles tendon (HP:0005109)4.08438913
9Trismus (HP:0000211)4.06164881
10Esophageal atresia (HP:0002032)3.98374500
11Flat capital femoral epiphysis (HP:0003370)3.82730400
12Nasal polyposis (HP:0100582)3.71256070
13Large for gestational age (HP:0001520)3.62576537
14Chronic sinusitis (HP:0011109)3.56715107
15Acute necrotizing encephalopathy (HP:0006965)3.55041504
16Elbow flexion contracture (HP:0002987)3.50293948
17Parakeratosis (HP:0001036)3.33905454
18Joint hemorrhage (HP:0005261)3.16626891
19Reticulocytopenia (HP:0001896)3.14940559
20Overlapping toe (HP:0001845)3.13980322
21Acute encephalopathy (HP:0006846)3.11616032
22Progressive macrocephaly (HP:0004481)3.07144427
23Abnormal mitochondria in muscle tissue (HP:0008316)3.06715228
24Abnormality of the nasal mucosa (HP:0000433)3.06423087
25Chronic hepatic failure (HP:0100626)3.03632083
26Abnormality of cells of the erythroid lineage (HP:0012130)3.02927614
27Abnormal number of erythroid precursors (HP:0012131)3.01215403
28Septo-optic dysplasia (HP:0100842)2.99089435
29Respiratory difficulties (HP:0002880)2.93975409
30Mitochondrial inheritance (HP:0001427)2.93859084
31Renal Fanconi syndrome (HP:0001994)2.86040438
32Abnormality of aromatic amino acid family metabolism (HP:0004338)2.85670537
33Cerebral edema (HP:0002181)2.83550840
34Hypothermia (HP:0002045)2.79817723
35Rib fusion (HP:0000902)2.79361458
36Gastrointestinal atresia (HP:0002589)2.77679010
37Increased IgM level (HP:0003496)2.76371684
38Sparse eyelashes (HP:0000653)2.72040911
39Premature rupture of membranes (HP:0001788)2.69234143
40Type I transferrin isoform profile (HP:0003642)2.68890469
41Atrioventricular block (HP:0001678)2.67531688
42Hypoglycemic seizures (HP:0002173)2.66214377
43Hyperlipoproteinemia (HP:0010980)2.65252416
44Focal motor seizures (HP:0011153)2.64451498
45Dynein arm defect of respiratory motile cilia (HP:0012255)2.60063768
46Absent/shortened dynein arms (HP:0200106)2.60063768
47Midline defect of the nose (HP:0004122)2.59044088
48Optic disc pallor (HP:0000543)2.56863318
49Beaking of vertebral bodies (HP:0004568)2.54883786
50Hepatocellular necrosis (HP:0001404)2.53065923
513-Methylglutaconic aciduria (HP:0003535)2.42801604
52Hepatic necrosis (HP:0002605)2.42350091
53Renal cortical cysts (HP:0000803)2.39745563
54Increased CSF lactate (HP:0002490)2.35582012
55Increased hepatocellular lipid droplets (HP:0006565)2.34657006
56Recurrent gram-negative bacterial infections (HP:0005420)2.32340341
57Large earlobe (HP:0009748)2.32267461
58Flexion contracture of toe (HP:0005830)2.30039732
59Joint contractures involving the joints of the feet (HP:0100492)2.30039732
60Lipid accumulation in hepatocytes (HP:0006561)2.27492664
61Abnormal biliary tract physiology (HP:0012439)2.27251549
62Bile duct proliferation (HP:0001408)2.27251549
63Proximal placement of thumb (HP:0009623)2.26453817
64Abnormality of renal resorption (HP:0011038)2.26348479
65Intrahepatic cholestasis (HP:0001406)2.23789017
66Decreased central vision (HP:0007663)2.21986445
67Deviation of the thumb (HP:0009603)2.21216396
68Macrocytic anemia (HP:0001972)2.20937270
69Prolonged neonatal jaundice (HP:0006579)2.20719903
70Hypophosphatemic rickets (HP:0004912)2.20176679
71Hyperventilation (HP:0002883)2.19401182
72Hypoglycemic coma (HP:0001325)2.17281127
73Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.17137114
74Purpura (HP:0000979)2.16994075
75Pulmonary artery stenosis (HP:0004415)2.16276658
76Elevated erythrocyte sedimentation rate (HP:0003565)2.14703419
77Ectopia lentis (HP:0001083)2.12629304
78Thyroid-stimulating hormone excess (HP:0002925)2.10589913
79Abnormality of methionine metabolism (HP:0010901)2.09567205
80Protrusio acetabuli (HP:0003179)2.09422728
81Hypoplasia of the capital femoral epiphysis (HP:0003090)2.08487939
82Abnormality of secondary sexual hair (HP:0009888)2.07301014
83Abnormality of the axillary hair (HP:0100134)2.07301014
84Basal ganglia calcification (HP:0002135)2.06424160
85Abnormal pupillary function (HP:0007686)2.05975913
86Enlarged kidneys (HP:0000105)2.05678179
87Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.05342309
88Febrile seizures (HP:0002373)2.05060391
89Recurrent bronchitis (HP:0002837)2.03773403
90Increased intramyocellular lipid droplets (HP:0012240)2.03615274
91Wide intermamillary distance (HP:0006610)2.03424713
92Long toe (HP:0010511)2.03410970
93Hyperinsulinemic hypoglycemia (HP:0000825)2.02847953
94Osteomalacia (HP:0002749)2.02105382
95Wide nose (HP:0000445)2.01652601
96Abnormality of aspartate family amino acid metabolism (HP:0010899)1.98675096
97Vascular calcification (HP:0004934)1.97711973
98Hypoplastic pelvis (HP:0008839)1.96076485
99Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.95464607
100Abnormal protein N-linked glycosylation (HP:0012347)1.95464607
101Abnormal protein glycosylation (HP:0012346)1.95464607
102Abnormal glycosylation (HP:0012345)1.95464607
103Progressive inability to walk (HP:0002505)1.95108257
104Pancreatic islet-cell hyperplasia (HP:0004510)1.94954711
105Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.94303155
106Gingival bleeding (HP:0000225)1.94121480
107Progressive muscle weakness (HP:0003323)1.93826627
108Abnormal ciliary motility (HP:0012262)1.92692386
109Lactic acidosis (HP:0003128)1.92274488
110Clubbing of toes (HP:0100760)1.91324285
111Abnormality of the renal cortex (HP:0011035)1.87696013
112Increased muscle lipid content (HP:0009058)1.87357078
113Muscle hypertrophy of the lower extremities (HP:0008968)1.86946243
114Fair hair (HP:0002286)1.83961351
115Increased serum pyruvate (HP:0003542)1.83246554
116Abnormality of glycolysis (HP:0004366)1.83246554
117Menorrhagia (HP:0000132)1.82960876
118Symptomatic seizures (HP:0011145)1.82849385
119Trigonocephaly (HP:0000243)1.81988057
120Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.81978495
121Aplasia/Hypoplasia of the sacrum (HP:0008517)1.81976530
122Amyloidosis (HP:0011034)1.81628700
123Colon cancer (HP:0003003)1.81178183
124Abnormality of urine glucose concentration (HP:0011016)1.79599508
125Glycosuria (HP:0003076)1.79599508
126Reduced antithrombin III activity (HP:0001976)1.79101104
127Congenital stationary night blindness (HP:0007642)1.78809136
128Recurrent bacterial skin infections (HP:0005406)1.78759066
129Conjugated hyperbilirubinemia (HP:0002908)1.78574286
130Absent septum pellucidum (HP:0001331)1.78543546
131Optic nerve hypoplasia (HP:0000609)1.77735795
132Deep venous thrombosis (HP:0002625)1.77565711
133Ankle contracture (HP:0006466)1.77511671
134Vacuolated lymphocytes (HP:0001922)1.76993510
135Glomerulonephritis (HP:0000099)1.76697735
136Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.76037028
137Decreased activity of mitochondrial respiratory chain (HP:0008972)1.76037028
138Xanthomatosis (HP:0000991)1.75709749
139Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.75437176
140Abnormal lung lobation (HP:0002101)1.74600156
141Conical tooth (HP:0000698)1.73175170
142True hermaphroditism (HP:0010459)1.73026257
143Patchy hypopigmentation of hair (HP:0011365)1.72684488
144Arachnodactyly (HP:0001166)1.72074203
145Microvesicular hepatic steatosis (HP:0001414)1.71964969
146Keratoconus (HP:0000563)1.71719827
147Increased corneal curvature (HP:0100692)1.71719827
148Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.71550478
149Hypobetalipoproteinemia (HP:0003563)1.70370607
150Recurrent skin infections (HP:0001581)1.68942603
151White forelock (HP:0002211)1.68370011
152Lethargy (HP:0001254)1.67747666
153Cardiovascular calcification (HP:0011915)1.67284767
154Deep philtrum (HP:0002002)1.67277559
155Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.67101269
156Exercise intolerance (HP:0003546)1.66383328
157Dry hair (HP:0011359)1.65651064
158Recurrent abscess formation (HP:0002722)1.65564596
159Spontaneous abortion (HP:0005268)1.65262452
160Short middle phalanx of the 5th finger (HP:0004220)1.64822840
161Systemic lupus erythematosus (HP:0002725)1.64789892
162Abnormality of incisor morphology (HP:0011063)1.64752242
163Self-mutilation (HP:0000742)1.64527088
164Chromosomal breakage induced by crosslinking agents (HP:0003221)1.64033625
165Leukodystrophy (HP:0002415)1.63804812
166Respiratory failure (HP:0002878)1.63121418
167Bifid tongue (HP:0010297)1.63095090
168Blepharitis (HP:0000498)1.62879918
169Meckel diverticulum (HP:0002245)1.62099468
170Partial agenesis of the corpus callosum (HP:0001338)1.61083351
171Abolished electroretinogram (ERG) (HP:0000550)1.60362083
172X-linked dominant inheritance (HP:0001423)1.59812474
173Upper limb muscle weakness (HP:0003484)1.59792640
174Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.59710953
175Preauricular skin tag (HP:0000384)1.57957384
176Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.57366119
177Absent epiphyses (HP:0010577)1.57366119
178Arthrogryposis multiplex congenita (HP:0002804)1.56847705
179Abnormality of the ileum (HP:0001549)1.56740574
180Abnormality of the fingertips (HP:0001211)1.53797565
181Abnormality of dentin (HP:0010299)1.53515022
182Patellar aplasia (HP:0006443)1.52265367
183Prominent nose (HP:0000448)1.51954010
184Gout (HP:0001997)1.51444785
185Bifid uvula (HP:0000193)1.50689922
186Abnormality of macular pigmentation (HP:0008002)1.49462527
187Chromsome breakage (HP:0040012)1.47664792
188Camptodactyly of toe (HP:0001836)1.47012638
189Aplasia/Hypoplasia of the patella (HP:0006498)1.46967171
190Flat face (HP:0012368)1.46799860
191Adactyly (HP:0009776)1.46698650

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR24.33914937
2CASK4.26532936
3MOS3.78271763
4TNIK3.24573180
5STK102.89216830
6BUB12.73517772
7STK162.59927628
8PTK22.58801196
9PBK2.52422812
10NME22.40981197
11IRAK32.35845051
12BLK2.35232614
13IRAK42.22526318
14TAOK22.19998485
15GRK72.11190513
16MUSK2.07423373
17RIPK42.03148329
18INSRR2.00486850
19TTK1.98311388
20ADRBK21.93486644
21MAP3K141.89164793
22VRK21.88381004
23EIF2AK11.83406900
24PDK21.81176686
25ZAK1.77272262
26SRPK11.75836924
27TSSK61.71538317
28CDC71.71116559
29PLK31.68974206
30IRAK11.66105690
31IRAK21.66099635
32EPHA31.61961301
33PKN11.60632455
34MAP3K101.60526874
35EIF2AK31.57842200
36BMPR21.57426239
37NEK11.56669032
38MAP3K131.48225076
39TAOK31.46807911
40GRK51.46638796
41BMPR1B1.43648416
42STK391.40454194
43PIK3CG1.39458343
44KIT1.39326015
45CLK11.38079228
46WNK31.35053358
47PAK41.31706398
48FES1.29853428
49IKBKE1.28261125
50MST41.27154002
51WEE11.26949882
52MAP3K121.23329130
53OXSR11.23005705
54LRRK21.22643321
55YES11.20763856
56GRK11.19945277
57PIK3CA1.19325662
58CHEK21.19238951
59MAP3K31.16879874
60MYLK1.15384049
61TXK1.13020751
62MAP2K71.12300102
63BRSK21.10239570
64NUAK11.09492355
65MAPKAPK51.08343545
66NME11.05543272
67TBK11.04154721
68CDK191.01797530
69ABL20.99597897
70PLK10.98849153
71BCKDK0.98516935
72LMTK20.97853904
73IKBKB0.96523335
74EIF2AK20.96011253
75TYK20.95189037
76JAK10.94713218
77VRK10.94567033
78AURKA0.91746806
79MAPK130.91460302
80MET0.89935491
81PRKCE0.89911971
82DMPK0.89151889
83SIK30.88718976
84PLK40.88474903
85PRKCQ0.87782407
86TIE10.87565485
87OBSCN0.86963646
88BCR0.86735295
89TEC0.86289898
90EPHB10.84616580
91EPHA20.83536439
92STK30.83399953
93TAOK10.79934401
94CDK70.79665720
95FGFR10.78911280
96JAK30.77543968
97PRPF4B0.75888381
98ERBB40.74582535
99CAMK2A0.74327838
100MAP3K80.72619166
101CDK30.71884890
102NLK0.71401858
103TRIM280.71249045
104DYRK20.70420675
105PASK0.70397608
106PHKG10.68516023
107PHKG20.68516023
108CAMK2B0.68439303
109CDK80.68212956
110CHEK10.67480168
111LYN0.67355679
112NTRK30.67314552
113ILK0.67312007
114PDGFRA0.66705662
115CAMK2D0.66538915
116AURKB0.66119757
117PRKAA20.66088801
118NEK60.65990259
119SYK0.65456939
120MAPK120.64239363
121LCK0.64040784
122TRPM70.62636797
123STK38L0.61340156
124MST1R0.59964736
125EPHA40.59909288
126CAMK2G0.58637961
127FGR0.57700379
128FGFR40.57357778
129FGFR20.57153302
130MAP2K40.56493495
131CSNK2A10.55022232
132TLK10.54441008
133ADRBK10.54431005
134BRSK10.54344774
135PAK10.53903743
136NEK20.52075948
137CAMK1G0.51854118
138FLT30.51791111
139MKNK20.51618066
140CSNK2A20.51346939
141RAF10.51098319
142MAP2K30.51056888
143LATS20.50370593
144STK240.50253192
145PRKG10.50145988
146SIK20.50143650
147PRKACA0.48318221
148SGK20.48156601
149CDK40.48056276
150TNK20.47532071
151CAMKK20.47483737
152MKNK10.47438816
153MAPK40.46002202
154SGK4940.45677588
155SGK2230.45677588
156WNK40.45151396
157PAK20.44475190
158PNCK0.43500745
159BTK0.42471615
160NTRK10.41247206
161RPS6KA50.40341978
162HCK0.40097622
163CSF1R0.39980748
164CSNK1G30.39947018
165PIM20.39867221
166FER0.39806647
167ACVR1B0.38999556
168LATS10.38277681
169TAF10.38104332
170ATM0.38080373
171DDR20.37905453
172CSNK1G10.35224624
173ATR0.33566283
174ARAF0.32628659
175TGFBR10.32207846
176CSNK1E0.31084910

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.33868360
2Ribosome_Homo sapiens_hsa030103.63469850
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.84943570
4Oxidative phosphorylation_Homo sapiens_hsa001902.80540555
5Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.77061232
6RNA polymerase_Homo sapiens_hsa030202.57469221
7Fatty acid elongation_Homo sapiens_hsa000622.56285291
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.51202668
9Primary bile acid biosynthesis_Homo sapiens_hsa001202.41869355
10DNA replication_Homo sapiens_hsa030302.35839285
11Mismatch repair_Homo sapiens_hsa034302.33311982
12Basal transcription factors_Homo sapiens_hsa030222.25454851
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.20214657
14Staphylococcus aureus infection_Homo sapiens_hsa051502.10750640
15One carbon pool by folate_Homo sapiens_hsa006701.96343371
16Parkinsons disease_Homo sapiens_hsa050121.94773763
17Histidine metabolism_Homo sapiens_hsa003401.92005620
18Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.89917450
19Complement and coagulation cascades_Homo sapiens_hsa046101.88018946
20Allograft rejection_Homo sapiens_hsa053301.84676316
21Peroxisome_Homo sapiens_hsa041461.84530529
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.79831178
23RNA transport_Homo sapiens_hsa030131.79004305
24Tryptophan metabolism_Homo sapiens_hsa003801.76162657
25Nicotine addiction_Homo sapiens_hsa050331.72333571
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.70496351
27Alzheimers disease_Homo sapiens_hsa050101.70314251
28Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.69214459
29Butanoate metabolism_Homo sapiens_hsa006501.67928095
30Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.65469844
31Propanoate metabolism_Homo sapiens_hsa006401.60079447
32Graft-versus-host disease_Homo sapiens_hsa053321.56743595
33Selenocompound metabolism_Homo sapiens_hsa004501.55888234
34Cell cycle_Homo sapiens_hsa041101.55792574
35Spliceosome_Homo sapiens_hsa030401.55572157
36Steroid biosynthesis_Homo sapiens_hsa001001.53970798
37Fatty acid degradation_Homo sapiens_hsa000711.53272278
38Autoimmune thyroid disease_Homo sapiens_hsa053201.50724461
39Nucleotide excision repair_Homo sapiens_hsa034201.50237932
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.48086760
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.47514923
42Steroid hormone biosynthesis_Homo sapiens_hsa001401.47021397
43Pyrimidine metabolism_Homo sapiens_hsa002401.44859588
44beta-Alanine metabolism_Homo sapiens_hsa004101.40924696
45Protein export_Homo sapiens_hsa030601.40830776
46Chemical carcinogenesis_Homo sapiens_hsa052041.38263095
47Phenylalanine metabolism_Homo sapiens_hsa003601.36490398
48Rheumatoid arthritis_Homo sapiens_hsa053231.35965417
49Pentose and glucuronate interconversions_Homo sapiens_hsa000401.35336892
50Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.34355936
51Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.32829699
52Retinol metabolism_Homo sapiens_hsa008301.32493366
53Tyrosine metabolism_Homo sapiens_hsa003501.32318733
54Homologous recombination_Homo sapiens_hsa034401.31920102
55ECM-receptor interaction_Homo sapiens_hsa045121.28994143
56Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.28918933
57Non-homologous end-joining_Homo sapiens_hsa034501.26454560
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.25668303
59Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.23749561
60Biosynthesis of amino acids_Homo sapiens_hsa012301.22967454
61N-Glycan biosynthesis_Homo sapiens_hsa005101.21461967
62Fatty acid metabolism_Homo sapiens_hsa012121.21359763
63Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.20447984
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.19498966
65Base excision repair_Homo sapiens_hsa034101.17890642
66Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.17272929
67ABC transporters_Homo sapiens_hsa020101.16519547
68African trypanosomiasis_Homo sapiens_hsa051431.16406372
69Serotonergic synapse_Homo sapiens_hsa047261.14100643
70Intestinal immune network for IgA production_Homo sapiens_hsa046721.13877647
71Fanconi anemia pathway_Homo sapiens_hsa034601.12570790
72Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.11683645
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.09541250
74PPAR signaling pathway_Homo sapiens_hsa033201.08008223
75p53 signaling pathway_Homo sapiens_hsa041151.05953082
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.05072975
77Glutathione metabolism_Homo sapiens_hsa004801.01612443
78Ether lipid metabolism_Homo sapiens_hsa005651.01177461
79Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.00671723
80Vitamin B6 metabolism_Homo sapiens_hsa007501.00215303
81RNA degradation_Homo sapiens_hsa030180.99944134
82Arginine biosynthesis_Homo sapiens_hsa002200.97539577
83Malaria_Homo sapiens_hsa051440.96217911
84Huntingtons disease_Homo sapiens_hsa050160.94930337
85Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.94674716
86Collecting duct acid secretion_Homo sapiens_hsa049660.94541219
87Asthma_Homo sapiens_hsa053100.93419116
88Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.93110303
89Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.92526560
90Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.92041107
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.92039885
92Maturity onset diabetes of the young_Homo sapiens_hsa049500.91699647
93Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.91668214
94Galactose metabolism_Homo sapiens_hsa000520.88502262
95Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.88442909
96Purine metabolism_Homo sapiens_hsa002300.87304064
97Carbon metabolism_Homo sapiens_hsa012000.87025668
98Phototransduction_Homo sapiens_hsa047440.85158614
99Arachidonic acid metabolism_Homo sapiens_hsa005900.85044671
100Vitamin digestion and absorption_Homo sapiens_hsa049770.82917592
101Cardiac muscle contraction_Homo sapiens_hsa042600.82523581
102Fat digestion and absorption_Homo sapiens_hsa049750.81333784
103Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.80958041
104NF-kappa B signaling pathway_Homo sapiens_hsa040640.79413033
105Sulfur metabolism_Homo sapiens_hsa009200.79245572
106Protein digestion and absorption_Homo sapiens_hsa049740.78789931
107Arginine and proline metabolism_Homo sapiens_hsa003300.77440780
108Toll-like receptor signaling pathway_Homo sapiens_hsa046200.76719320
109Sphingolipid metabolism_Homo sapiens_hsa006000.74349930
110Type I diabetes mellitus_Homo sapiens_hsa049400.73402311
1112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.73278053
112Morphine addiction_Homo sapiens_hsa050320.70675935
113Measles_Homo sapiens_hsa051620.70060883
114Starch and sucrose metabolism_Homo sapiens_hsa005000.69066892
115GABAergic synapse_Homo sapiens_hsa047270.68105384
116Primary immunodeficiency_Homo sapiens_hsa053400.67884599
117Mineral absorption_Homo sapiens_hsa049780.67323120
118Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65753423
119Lysine degradation_Homo sapiens_hsa003100.65312395
120Linoleic acid metabolism_Homo sapiens_hsa005910.65139990
121Pentose phosphate pathway_Homo sapiens_hsa000300.64876733
122Taste transduction_Homo sapiens_hsa047420.63794750
123Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62949443
124Phagosome_Homo sapiens_hsa041450.61691289
125RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.61395424
126TGF-beta signaling pathway_Homo sapiens_hsa043500.61290652
127Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.60530050
128Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.59778905
129mRNA surveillance pathway_Homo sapiens_hsa030150.59464198
130Metabolic pathways_Homo sapiens_hsa011000.57311947
131Dilated cardiomyopathy_Homo sapiens_hsa054140.56938646
132Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54159915
133Hippo signaling pathway_Homo sapiens_hsa043900.52515201
134Fructose and mannose metabolism_Homo sapiens_hsa000510.52178303
135Pertussis_Homo sapiens_hsa051330.52042799
136Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51731714
137Leishmaniasis_Homo sapiens_hsa051400.51706546
138Other glycan degradation_Homo sapiens_hsa005110.50906648
139alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.49590404
140Glutamatergic synapse_Homo sapiens_hsa047240.48526132
141Caffeine metabolism_Homo sapiens_hsa002320.48367953
142Pyruvate metabolism_Homo sapiens_hsa006200.47063073
143SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46732071
144Basal cell carcinoma_Homo sapiens_hsa052170.46325247
145Folate biosynthesis_Homo sapiens_hsa007900.46242702
146Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.45357515
147Calcium signaling pathway_Homo sapiens_hsa040200.44818362
148Adherens junction_Homo sapiens_hsa045200.44274752
149Hematopoietic cell lineage_Homo sapiens_hsa046400.44185174
150Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44081265
151Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41133941
152Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39972442
153Drug metabolism - other enzymes_Homo sapiens_hsa009830.39067099
154Ovarian steroidogenesis_Homo sapiens_hsa049130.37726141
155Regulation of autophagy_Homo sapiens_hsa041400.37227621
156NOD-like receptor signaling pathway_Homo sapiens_hsa046210.34641041
157Axon guidance_Homo sapiens_hsa043600.28845706

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