BDKRB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Bradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate responses to these pathophysiologic conditions. The protein encoded by this gene is one of these receptors and is synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular response to arsenic-containing substance (GO:0071243)9.36860450
2L-ascorbic acid metabolic process (GO:0019852)8.64898514
3negative regulation of leukocyte chemotaxis (GO:0002689)7.91598017
4oxygen transport (GO:0015671)7.75198256
5sequestering of extracellular ligand from receptor (GO:0035581)7.36884909
6regulation of histone phosphorylation (GO:0033127)7.09525613
7stress fiber assembly (GO:0043149)6.85881193
8photoreceptor cell differentiation (GO:0046530)6.69664384
9eye photoreceptor cell differentiation (GO:0001754)6.69664384
10receptor recycling (GO:0001881)6.46313873
11bone trabecula formation (GO:0060346)5.88013459
12regulation of meiosis I (GO:0060631)5.77393991
13positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003605.61630463
14extracellular fibril organization (GO:0043206)5.60281083
15vesicle targeting (GO:0006903)5.59107901
16protein heterotrimerization (GO:0070208)5.54987768
17ncRNA 3-end processing (GO:0043628)5.39222626
18negative regulation of cardiac muscle tissue growth (GO:0055022)5.26894633
19negative regulation of heart growth (GO:0061117)5.26894633
20positive regulation of meiosis (GO:0045836)5.17429707
21vitamin A metabolic process (GO:0006776)5.03996025
22mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)4.91439005
23positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021104.91439005
24fibril organization (GO:0097435)4.88161795
25type B pancreatic cell proliferation (GO:0044342)4.80508122
26negative regulation of cAMP-mediated signaling (GO:0043951)4.77214240
27positive regulation of meiotic cell cycle (GO:0051446)4.73951175
28protein retention in ER lumen (GO:0006621)4.62625609
29adhesion of symbiont to host cell (GO:0044650)4.59410929
30virion attachment to host cell (GO:0019062)4.59410929
31lung vasculature development (GO:0060426)4.56000313
32pericardium development (GO:0060039)4.54574234
33regulation of monocyte chemotaxis (GO:0090025)4.47469501
34negative regulation of Rho protein signal transduction (GO:0035024)4.43277902
35cellular zinc ion homeostasis (GO:0006882)4.41503758
36gas transport (GO:0015669)4.35617042
37endocardial cushion development (GO:0003197)4.25488235
38mitochondrial fragmentation involved in apoptotic process (GO:0043653)4.25095216
39response to arsenic-containing substance (GO:0046685)4.14895889
40substrate-dependent cell migration (GO:0006929)4.12016337
41maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.11904223
42dermatan sulfate biosynthetic process (GO:0030208)4.02883070
43cell aggregation (GO:0098743)4.00196572
44cartilage condensation (GO:0001502)4.00196572
45negative regulation of axon extension involved in axon guidance (GO:0048843)3.94552678
46inner cell mass cell proliferation (GO:0001833)3.89298596
47metanephric mesenchyme development (GO:0072075)3.88645160
48positive regulation of mitochondrial fission (GO:0090141)3.87017155
49endodermal cell differentiation (GO:0035987)3.84147331
50negative regulation of viral release from host cell (GO:1902187)3.83247553
51extracellular regulation of signal transduction (GO:1900115)3.81561573
52extracellular negative regulation of signal transduction (GO:1900116)3.81561573
53negative regulation of axon guidance (GO:1902668)3.79121650
54blood vessel maturation (GO:0001955)3.75582221
55regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.74957976
56positive regulation of p38MAPK cascade (GO:1900745)3.74718073
57response to hyperoxia (GO:0055093)3.71346025
58response to increased oxygen levels (GO:0036296)3.71346025
59adhesion of symbiont to host (GO:0044406)3.71236357
60collagen fibril organization (GO:0030199)3.70341370
61regulation of integrin-mediated signaling pathway (GO:2001044)3.69802522
62dermatan sulfate metabolic process (GO:0030205)3.69531597
63outer ear morphogenesis (GO:0042473)3.68675185
64positive regulation of mitochondrial membrane permeability (GO:0035794)3.68281535
65histone H2A ubiquitination (GO:0033522)3.62278372
66female mating behavior (GO:0060180)3.59718178
67smooth muscle tissue development (GO:0048745)3.59267006
68regulation of female receptivity (GO:0045924)3.54716291
69negative regulation of smooth muscle cell migration (GO:0014912)3.53807865
70cell migration involved in heart development (GO:0060973)3.52008859
71negative regulation of mast cell activation (GO:0033004)3.49049791
72skin morphogenesis (GO:0043589)3.48640699
73middle ear morphogenesis (GO:0042474)3.48158503
74positive regulation of male gonad development (GO:2000020)3.46311793
75cellular response to vitamin (GO:0071295)3.43389697
76collagen catabolic process (GO:0030574)3.43058789
77heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.42497525
78regulation of transforming growth factor beta1 production (GO:0032908)3.41436727
79mesenchymal cell proliferation (GO:0010463)3.38048654
80kidney mesenchyme development (GO:0072074)3.37970034
81regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.36241678
82zinc ion homeostasis (GO:0055069)3.35796481
83collagen metabolic process (GO:0032963)3.34621773
84negative regulation of cardiac muscle tissue development (GO:0055026)3.32870177
85regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.32285201
86inner ear receptor cell development (GO:0060119)3.29186700
87mesenchymal-epithelial cell signaling (GO:0060638)3.28450698
88respiratory tube development (GO:0030323)3.28158899
89bone resorption (GO:0045453)3.26878572
90chondrocyte development (GO:0002063)3.23362267
91extracellular matrix disassembly (GO:0022617)3.22869699
92snRNA processing (GO:0016180)3.22051325
93ovulation cycle (GO:0042698)3.19553907
94glutathione derivative biosynthetic process (GO:1901687)3.17994494
95glutathione derivative metabolic process (GO:1901685)3.17994494
96chondrocyte proliferation (GO:0035988)3.16873066
97multicellular organismal macromolecule metabolic process (GO:0044259)3.16179726
98blood circulation (GO:0008015)3.15903968
99response to laminar fluid shear stress (GO:0034616)3.14770308
100response to redox state (GO:0051775)3.13510181
101nonmotile primary cilium assembly (GO:0035058)3.13338052
102regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.13232040
103multicellular organismal catabolic process (GO:0044243)3.12702288
104positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-3.11594242
105olfactory bulb development (GO:0021772)3.10280401
106negative regulation of viral entry into host cell (GO:0046597)3.10077657
107positive regulation of astrocyte differentiation (GO:0048711)3.09749233
108homocysteine metabolic process (GO:0050667)3.08622318
109pattern specification involved in kidney development (GO:0061004)3.08218548
110peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.08189709
111positive regulation of DNA recombination (GO:0045911)3.08150274
112lung lobe morphogenesis (GO:0060463)3.07262143
113gonadal mesoderm development (GO:0007506)3.06090941
114renal tubule development (GO:0061326)3.05697603
115nucleoside diphosphate catabolic process (GO:0009134)3.05427688
116lymphangiogenesis (GO:0001946)3.04131479
117cell migration involved in sprouting angiogenesis (GO:0002042)3.02552723
118mesodermal cell differentiation (GO:0048333)3.01884821
119positive regulation of odontogenesis (GO:0042482)3.01623878
120cellular response to fluid shear stress (GO:0071498)3.01481153
121multicellular organismal metabolic process (GO:0044236)3.01010784
122negative regulation of leukocyte migration (GO:0002686)3.00965102
123cellular response to nicotine (GO:0071316)3.00930370
124cell adhesion mediated by integrin (GO:0033627)3.00858829
125negative regulation of synaptic transmission, GABAergic (GO:0032229)2.99911017
126positive regulation of blood vessel endothelial cell migration (GO:0043536)2.99767954
127tooth mineralization (GO:0034505)2.98582551
128polarized epithelial cell differentiation (GO:0030859)2.96729867
129negative regulation of osteoblast proliferation (GO:0033689)2.95339553
130negative regulation of nitric-oxide synthase activity (GO:0051001)2.93949482
131axon extension involved in axon guidance (GO:0048846)2.93527742
132neuron projection extension involved in neuron projection guidance (GO:1902284)2.93527742
133regulation of p38MAPK cascade (GO:1900744)2.92670359
134regulation of axon guidance (GO:1902667)2.92538728
135blood vessel remodeling (GO:0001974)2.91153301
136cellular response to vitamin D (GO:0071305)2.90936726
137regulation of female gonad development (GO:2000194)2.90440484
138extracellular matrix assembly (GO:0085029)2.90414527
139regulation of axon extension involved in axon guidance (GO:0048841)2.90252955
140face morphogenesis (GO:0060325)2.87871558
141regulation of male gonad development (GO:2000018)2.85372585
142regulation of type B pancreatic cell apoptotic process (GO:2000674)2.83156180
143heparan sulfate proteoglycan metabolic process (GO:0030201)2.82471758
144positive regulation of osteoblast proliferation (GO:0033690)2.82275366
145regulation of plasminogen activation (GO:0010755)2.81541756
146induction of positive chemotaxis (GO:0050930)2.80425424
147positive regulation of protein autophosphorylation (GO:0031954)2.80011695
148keratan sulfate catabolic process (GO:0042340)2.78701060
149proteoglycan biosynthetic process (GO:0030166)2.74619750
150regulation of extracellular matrix disassembly (GO:0010715)2.74263431
151regulation of smooth muscle cell migration (GO:0014910)2.71972883
152substrate adhesion-dependent cell spreading (GO:0034446)2.70939730
153regulation of metalloenzyme activity (GO:0048552)2.66205351
154cellular response to interferon-alpha (GO:0035457)2.64199412
155mesenchymal cell differentiation involved in kidney development (GO:0072161)2.64066060
156mesenchymal cell differentiation involved in renal system development (GO:2001012)2.64066060
157cell differentiation involved in metanephros development (GO:0072202)2.63177908
158vascular endothelial growth factor signaling pathway (GO:0038084)2.62870455
159peptidyl-proline hydroxylation (GO:0019511)2.62840696
160regulation of apoptotic process involved in morphogenesis (GO:1902337)2.62027346
161regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.59948702
162positive regulation of fibroblast migration (GO:0010763)2.58350395
163regulation of interleukin-8 secretion (GO:2000482)2.58171892
164platelet dense granule organization (GO:0060155)2.56513533
165proteoglycan metabolic process (GO:0006029)2.55101712
166cellular response to amino acid stimulus (GO:0071230)2.53453005
167cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.51512371
168extracellular matrix organization (GO:0030198)2.50396509
169branching involved in salivary gland morphogenesis (GO:0060445)2.50232451
170extracellular structure organization (GO:0043062)2.49527980
171positive regulation of positive chemotaxis (GO:0050927)2.49256906
172negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.48699192
173positive regulation of extracellular matrix organization (GO:1903055)2.48172497
174negative chemotaxis (GO:0050919)2.46501598

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human6.52818746
2STAT6_21828071_ChIP-Seq_BEAS2B_Human4.11517882
3PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.86983041
4PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.60706730
5ESR1_21235772_ChIP-Seq_MCF-7_Human2.96648697
6RARG_19884340_ChIP-ChIP_MEFs_Mouse2.73977634
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.61890986
8KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.35381708
9KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.35381708
10KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.35381708
11CLOCK_20551151_ChIP-Seq_293T_Human2.12243270
12ESR2_21235772_ChIP-Seq_MCF-7_Human2.11461743
13TP63_17297297_ChIP-ChIP_HaCaT_Human2.10967757
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.08875929
15WT1_19549856_ChIP-ChIP_CCG9911_Human2.06362755
16HIF1A_21447827_ChIP-Seq_MCF-7_Human2.03192530
17CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.96723921
18FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.92324036
19FOXO3_23340844_ChIP-Seq_DLD1_Human1.90543226
20* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.86927471
21ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.82747920
22EP300_21415370_ChIP-Seq_HL-1_Mouse1.81527325
23SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.80848015
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.80487745
25PIAS1_25552417_ChIP-Seq_VCAP_Human1.78225146
26GBX2_23144817_ChIP-Seq_PC3_Human1.78009009
27SALL1_21062744_ChIP-ChIP_HESCs_Human1.75424506
28DROSHA_22980978_ChIP-Seq_HELA_Human1.74266792
29PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.73422463
30TP53_18474530_ChIP-ChIP_U2OS_Human1.73029465
31CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.72877106
32* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.72427692
33SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.72288079
34ZNF274_21170338_ChIP-Seq_K562_Hela1.70395179
35* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.69658413
36EZH2_18974828_ChIP-Seq_MESCs_Mouse1.68600220
37RNF2_18974828_ChIP-Seq_MESCs_Mouse1.68600220
38SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.62931719
39WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.61932421
40* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.61854174
41* CJUN_26792858_Chip-Seq_BT549_Human1.59239124
42TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.53179834
43EZH2_27304074_Chip-Seq_ESCs_Mouse1.48158306
44BP1_19119308_ChIP-ChIP_Hs578T_Human1.47511067
45SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.47163475
46EED_16625203_ChIP-ChIP_MESCs_Mouse1.46362910
47IKZF1_21737484_ChIP-ChIP_HCT116_Human1.45395947
48RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.44753179
49TCF3_18692474_ChIP-Seq_MEFs_Mouse1.44531175
50PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.43802875
51KDM2B_26808549_Chip-Seq_K562_Human1.40068044
52AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.39497528
53PPAR_26484153_Chip-Seq_NCI-H1993_Human1.39395065
54CBX2_27304074_Chip-Seq_ESCs_Mouse1.39078565
55ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.37219315
56SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.37085493
57* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.35723055
58PCGF2_27294783_Chip-Seq_ESCs_Mouse1.35640070
59TCF4_18268006_ChIP-ChIP_LS174T_Human1.35629438
60ZFP281_18757296_ChIP-ChIP_E14_Mouse1.35061399
61TP53_22127205_ChIP-Seq_IMR90_Human1.34562976
62FLI1_27457419_Chip-Seq_LIVER_Mouse1.31332342
63SMAD4_21799915_ChIP-Seq_A2780_Human1.29832506
64TP53_16413492_ChIP-PET_HCT116_Human1.29356534
65SA1_22415368_ChIP-Seq_MEFs_Mouse1.29245022
66PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.28440429
67GATA1_26923725_Chip-Seq_HPCs_Mouse1.25438758
68SMC3_22415368_ChIP-Seq_MEFs_Mouse1.25410024
69RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.24138036
70RNF2_27304074_Chip-Seq_ESCs_Mouse1.23402846
71FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.22613591
72ERG_21242973_ChIP-ChIP_JURKAT_Human1.21838442
73KDM2B_26808549_Chip-Seq_SUP-B15_Human1.20484094
74ARNT_22903824_ChIP-Seq_MCF-7_Human1.20303196
75MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19547753
76MTF2_20144788_ChIP-Seq_MESCs_Mouse1.19276861
77SMC1_22415368_ChIP-Seq_MEFs_Mouse1.19014005
78TP53_20018659_ChIP-ChIP_R1E_Mouse1.18606299
79SMAD_19615063_ChIP-ChIP_OVARY_Human1.16109655
80SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.15833288
81BRD4_25478319_ChIP-Seq_HGPS_Human1.15776488
82CTBP2_25329375_ChIP-Seq_LNCAP_Human1.14951078
83BCAT_22108803_ChIP-Seq_LS180_Human1.14267085
84NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14195685
85NRF2_20460467_ChIP-Seq_MEFs_Mouse1.13862334
86NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.13862334
87SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13320093
88SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13194316
89P300_19829295_ChIP-Seq_ESCs_Human1.12480161
90AR_21572438_ChIP-Seq_LNCaP_Human1.12153123
91SALL4_18804426_ChIP-ChIP_XEN_Mouse1.11555259
92* PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human1.11390099
93BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.10564768
94JARID2_20075857_ChIP-Seq_MESCs_Mouse1.10327160
95PCGF2_27294783_Chip-Seq_NPCs_Mouse1.09886426
96RING1B_27294783_Chip-Seq_NPCs_Mouse1.09754851
97AHR_22903824_ChIP-Seq_MCF-7_Human1.09644249
98EZH2_27294783_Chip-Seq_ESCs_Mouse1.09587860
99AR_25329375_ChIP-Seq_VCAP_Human1.09444772
100BMI1_23680149_ChIP-Seq_NPCS_Mouse1.09343823
101EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.09306830
102CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09255112
103POU3F2_20337985_ChIP-ChIP_501MEL_Human1.08471824
104JUN_21703547_ChIP-Seq_K562_Human1.07666601
105EZH2_27294783_Chip-Seq_NPCs_Mouse1.06372513
106OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05002333
107SUZ12_27294783_Chip-Seq_ESCs_Mouse1.04470220
108SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.04150447
109VDR_24787735_ChIP-Seq_THP-1_Human1.04127617
110TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.03841574
111TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.03447879
112MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.03406274
113TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02420849
114* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.01467284
115KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.00649874
116HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.00183901
117JARID2_20064375_ChIP-Seq_MESCs_Mouse0.98984369
118* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98858301
119GATA2_21666600_ChIP-Seq_HMVEC_Human0.98840378
120RING1B_27294783_Chip-Seq_ESCs_Mouse0.97689933
121CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.97258850
122* TP53_23651856_ChIP-Seq_MEFs_Mouse0.97064902
123NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.97010825
124SUZ12_27294783_Chip-Seq_NPCs_Mouse0.96291216
125ZNF217_24962896_ChIP-Seq_MCF-7_Human0.95438033
126STAT3_23295773_ChIP-Seq_U87_Human0.95419742
127SOX2_20726797_ChIP-Seq_SW620_Human0.95412488
128CDX2_19796622_ChIP-Seq_MESCs_Mouse0.94094841
129CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.93794401
130SMAD3_21741376_ChIP-Seq_EPCs_Human0.93529105
131CBP_20019798_ChIP-Seq_JUKART_Human0.93306207
132IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.93306207
133EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.92424412
134KDM2B_26808549_Chip-Seq_REH_Human0.92407387
135SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.92045960
136* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.90216624
137NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.88634030
138TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.88604499
139SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.88304230
140TOP2B_26459242_ChIP-Seq_MCF-7_Human0.88236531
141MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.85558346
142* CTBP1_25329375_ChIP-Seq_LNCAP_Human0.84834380
143* TP63_23658742_ChIP-Seq_EP156T_Human0.84754267
144RXR_22158963_ChIP-Seq_LIVER_Mouse0.82771502
145TBX20_22328084_ChIP-Seq_HEART_Mouse0.82491715
146TBX20_22080862_ChIP-Seq_HEART_Mouse0.82491715
147ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.82479894
148ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.82164611
149ZFP281_27345836_Chip-Seq_ESCs_Mouse0.81604925
150PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.79300590

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001958_emphysema6.49796677
2MP0006054_spinal_hemorrhage6.09409082
3MP0010368_abnormal_lymphatic_system4.58350943
4MP0005503_abnormal_tendon_morphology4.44751740
5MP0001542_abnormal_bone_strength4.17686020
6MP0003950_abnormal_plasma_membrane3.98417948
7MP0003011_delayed_dark_adaptation3.74693296
8MP0008438_abnormal_cutaneous_collagen3.53451193
9MP0003279_aneurysm3.29902529
10MP0004883_abnormal_blood_vessel3.08699576
11MP0009384_cardiac_valve_regurgitation2.80383714
12MP0005275_abnormal_skin_tensile2.64035760
13MP0000049_abnormal_middle_ear2.56555806
14MP0002254_reproductive_system_inflammat2.41324250
15MP0005623_abnormal_meninges_morphology2.40490865
16MP0005508_abnormal_skeleton_morphology2.35752051
17MP0010386_abnormal_urinary_bladder2.27273367
18MP0009780_abnormal_chondrocyte_physiolo2.26060581
19MP0001177_atelectasis2.25064733
20MP0005164_abnormal_response_to2.06682553
21MP0005257_abnormal_intraocular_pressure2.02319460
22MP0002249_abnormal_larynx_morphology1.91454403
23MP0009250_abnormal_appendicular_skeleto1.89954664
24MP0004484_altered_response_of1.89653809
25MP0003283_abnormal_digestive_organ1.89077634
26MP0000604_amyloidosis1.88802698
27MP0010030_abnormal_orbit_morphology1.87527489
28MP0000534_abnormal_ureter_morphology1.83289970
29MP0003115_abnormal_respiratory_system1.82528281
30MP0000163_abnormal_cartilage_morphology1.82168500
31MP0000767_abnormal_smooth_muscle1.81830712
32MP0001849_ear_inflammation1.77709611
33MP0001348_abnormal_lacrimal_gland1.75655752
34MP0005390_skeleton_phenotype1.71534197
35MP0004134_abnormal_chest_morphology1.64148576
36MP0005595_abnormal_vascular_smooth1.59426855
37MP0000013_abnormal_adipose_tissue1.55463598
38MP0002896_abnormal_bone_mineralization1.52395996
39MP0000681_abnormal_thyroid_gland1.50779584
40MP0003878_abnormal_ear_physiology1.50082054
41MP0005377_hearing/vestibular/ear_phenot1.50082054
42MP0001533_abnormal_skeleton_physiology1.46794676
43MP0002115_abnormal_skeleton_extremities1.43653811
44MP0002877_abnormal_melanocyte_morpholog1.41421680
45MP0003941_abnormal_skin_development1.39303596
46MP0001879_abnormal_lymphatic_vessel1.39075305
47MP0002133_abnormal_respiratory_system1.38647429
48MP0005388_respiratory_system_phenotype1.38647429
49MP0002295_abnormal_pulmonary_circulatio1.38365056
50MP0000538_abnormal_urinary_bladder1.37455444
51MP0000762_abnormal_tongue_morphology1.37305575
52MP0001986_abnormal_taste_sensitivity1.33252840
53MP0003795_abnormal_bone_structure1.33012435
54MP0003938_abnormal_ear_development1.32033966
55MP0002282_abnormal_trachea_morphology1.31988194
56MP0000428_abnormal_craniofacial_morphol1.31916260
57MP0005451_abnormal_body_composition1.28434414
58MP0002998_abnormal_bone_remodeling1.25840049
59MP0004885_abnormal_endolymph1.24585004
60MP0002102_abnormal_ear_morphology1.21222644
61MP0001299_abnormal_eye_distance/1.20962800
62MP0004859_abnormal_synaptic_plasticity1.17896034
63MP0001270_distended_abdomen1.17508167
64MP0002933_joint_inflammation1.15786027
65MP0002113_abnormal_skeleton_development1.15315359
66MP0001175_abnormal_lung_morphology1.14814039
67MP0005171_absent_coat_pigmentation1.08420016
68MP0005197_abnormal_uvea_morphology1.07487091
69MP0002127_abnormal_cardiovascular_syste1.02357785
70MP0003186_abnormal_redox_activity1.01124653
71MP0002735_abnormal_chemical_nociception1.00149414
72MP0003091_abnormal_cell_migration1.00043798
73MP0009053_abnormal_anal_canal0.98961318
74MP0002234_abnormal_pharynx_morphology0.98454279
75MP0002108_abnormal_muscle_morphology0.97032636
76MP0006082_CNS_inflammation0.96330222
77MP0009840_abnormal_foam_cell0.93760940
78MP0002116_abnormal_craniofacial_bone0.93411343
79MP0000427_abnormal_hair_cycle0.92892704
80MP0004272_abnormal_basement_membrane0.92781848
81MP0002177_abnormal_outer_ear0.91217547
82MP0000613_abnormal_salivary_gland0.89180561
83MP0002876_abnormal_thyroid_physiology0.88182036
84MP0000733_abnormal_muscle_development0.86581011
85MP0003705_abnormal_hypodermis_morpholog0.85604167
86MP0003123_paternal_imprinting0.84555457
87MP0003755_abnormal_palate_morphology0.84178902
88MP0002114_abnormal_axial_skeleton0.80976685
89MP0005084_abnormal_gallbladder_morpholo0.80842850
90MP0002736_abnormal_nociception_after0.80766961
91MP0002128_abnormal_blood_circulation0.79699221
92MP0003221_abnormal_cardiomyocyte_apopto0.78341083
93MP0002009_preneoplasia0.78136925
94MP0004858_abnormal_nervous_system0.78031317
95MP0001243_abnormal_dermal_layer0.77421659
96MP0000432_abnormal_head_morphology0.75615662
97MP0005165_increased_susceptibility_to0.75037664
98MP0002168_other_aberrant_phenotype0.74964157
99MP0002163_abnormal_gland_morphology0.74467513
100MP0000230_abnormal_systemic_arterial0.74297860
101MP0008775_abnormal_heart_ventricle0.73445937
102MP0001968_abnormal_touch/_nociception0.72209319
103MP0005023_abnormal_wound_healing0.72021795
104MP0001544_abnormal_cardiovascular_syste0.71588820
105MP0005385_cardiovascular_system_phenoty0.71588820
106MP0002751_abnormal_autonomic_nervous0.70723529
107MP0003942_abnormal_urinary_system0.70282237
108MP0004019_abnormal_vitamin_homeostasis0.70052839
109MP0003828_pulmonary_edema0.69728409
110MP0004133_heterotaxia0.67894563
111MP0000750_abnormal_muscle_regeneration0.67256917
112MP0003191_abnormal_cellular_cholesterol0.67075540
113* MP0004085_abnormal_heartbeat0.65590616
114MP0002089_abnormal_postnatal_growth/wei0.64182120
115MP0002109_abnormal_limb_morphology0.63772927
116MP0003937_abnormal_limbs/digits/tail_de0.63094442
117MP0000751_myopathy0.62292222
118MP0002111_abnormal_tail_morphology0.62213093
119MP0002932_abnormal_joint_morphology0.61353359
120MP0000003_abnormal_adipose_tissue0.60412090
121MP0003935_abnormal_craniofacial_develop0.58972778
122MP0001915_intracranial_hemorrhage0.58655152
123* MP0001970_abnormal_pain_threshold0.57465417
124MP0003448_altered_tumor_morphology0.56716471
125MP0003385_abnormal_body_wall0.55988738
126MP0002233_abnormal_nose_morphology0.55852857
127MP0000749_muscle_degeneration0.55672346
128MP0010352_gastrointestinal_tract_polyps0.55225043
129MP0003566_abnormal_cell_adhesion0.55173319
130MP0001614_abnormal_blood_vessel0.54671268
131MP0001346_abnormal_lacrimal_gland0.54417414
132MP0003724_increased_susceptibility_to0.53013449
133MP0000569_abnormal_digit_pigmentation0.52565497
134MP0003329_amyloid_beta_deposits0.51031944
135MP0000249_abnormal_blood_vessel0.50231172
136MP0000343_altered_response_to0.49899312
137MP0002938_white_spotting0.49809898
138MP0002060_abnormal_skin_morphology0.47300523
139MP0005319_abnormal_enzyme/_coenzyme0.47207826
140MP0005166_decreased_susceptibility_to0.46986265

Predicted human phenotypes

RankGene SetZ-score
1Pulmonary artery stenosis (HP:0004415)7.07195485
2Redundant skin (HP:0001582)6.78181158
3Follicular hyperkeratosis (HP:0007502)6.38238685
4Renovascular hypertension (HP:0100817)5.99504436
5Hyperacusis (HP:0010780)5.87888363
6Elfin facies (HP:0004428)5.84033175
7Overriding aorta (HP:0002623)5.72838429
8Renal duplication (HP:0000075)5.72772462
9Bladder diverticulum (HP:0000015)5.57724027
10Broad metatarsal (HP:0001783)5.10049782
11Absent frontal sinuses (HP:0002688)4.97706095
12Flat cornea (HP:0007720)4.91023467
13Insomnia (HP:0100785)4.87040838
14Soft skin (HP:0000977)4.74350113
15Papilledema (HP:0001085)4.66463747
16Cervical subluxation (HP:0003308)4.55564669
17Type 1 muscle fiber predominance (HP:0003803)4.44521051
18Premature rupture of membranes (HP:0001788)4.37513460
19Aortic regurgitation (HP:0001659)4.17222385
20Slender build (HP:0001533)4.12765781
21Turricephaly (HP:0000262)4.09867465
22Mitral regurgitation (HP:0001653)4.04872422
23Spondylolisthesis (HP:0003302)4.01674128
24Osteolytic defects of the hand bones (HP:0009699)3.95147486
25Osteolytic defects of the phalanges of the hand (HP:0009771)3.95147486
26Bowel diverticulosis (HP:0005222)3.94867354
27Abnormality of the diencephalon (HP:0010662)3.81565319
28Arterial tortuosity (HP:0005116)3.70566562
29Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)3.68243287
30Aortic valve stenosis (HP:0001650)3.63823949
31Hydroxyprolinuria (HP:0003080)3.59794578
32Abnormality of proline metabolism (HP:0010907)3.59794578
33Hypoventilation (HP:0002791)3.58497971
34Protrusio acetabuli (HP:0003179)3.47624543
35Emphysema (HP:0002097)3.43853787
36Increased corneal curvature (HP:0100692)3.35016797
37Keratoconus (HP:0000563)3.35016797
38Wormian bones (HP:0002645)3.32086568
39Adrenal hypoplasia (HP:0000835)3.12536559
40Genu recurvatum (HP:0002816)3.07391687
41Bronchomalacia (HP:0002780)3.06429949
42Wrist flexion contracture (HP:0001239)3.06078611
43Persistence of primary teeth (HP:0006335)3.00384312
44Hypoplastic toenails (HP:0001800)2.99537901
45Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.93854276
46Shallow orbits (HP:0000586)2.92498276
47Abnormality of the frontal sinuses (HP:0002687)2.91269931
48Breech presentation (HP:0001623)2.87201352
49Ridged nail (HP:0001807)2.81290277
50Fragile skin (HP:0001030)2.81258488
51Elbow flexion contracture (HP:0002987)2.80204830
52Short nail (HP:0001799)2.79979957
53Vertebral compression fractures (HP:0002953)2.77048462
54Hypercalcemia (HP:0003072)2.74545581
55Arnold-Chiari malformation (HP:0002308)2.66795518
56Abnormal delivery (HP:0001787)2.64152323
57Joint laxity (HP:0001388)2.61409512
58Abnormal rod and cone electroretinograms (HP:0008323)2.58386117
59Abnormal cartilage morphology (HP:0002763)2.56781683
60Bell-shaped thorax (HP:0001591)2.51091658
61Delayed closure of the anterior fontanelle (HP:0001476)2.50698326
62Megalocornea (HP:0000485)2.46869556
63Deviation of the hallux (HP:0010051)2.46790875
64Neonatal short-limb short stature (HP:0008921)2.45723232
65Increased nuchal translucency (HP:0010880)2.44515801
66Wide anterior fontanel (HP:0000260)2.44469755
67Blue sclerae (HP:0000592)2.42883351
68Ovoid vertebral bodies (HP:0003300)2.41821974
69Long toe (HP:0010511)2.40722246
70Coronal craniosynostosis (HP:0004440)2.38595433
71Protruding ear (HP:0000411)2.38027249
72Hyperextensible skin (HP:0000974)2.36972738
73Short hallux (HP:0010109)2.32230101
74Knee flexion contracture (HP:0006380)2.32022772
75Hypercalciuria (HP:0002150)2.29404669
76Flared iliac wings (HP:0002869)2.27291859
77Delayed gross motor development (HP:0002194)2.26257130
78Vascular tortuosity (HP:0004948)2.24438040
79Biconcave vertebral bodies (HP:0004586)2.23576340
80Atrophic scars (HP:0001075)2.21968658
81Concave nail (HP:0001598)2.18773894
82Inguinal hernia (HP:0000023)2.18571169
83Bony spicule pigmentary retinopathy (HP:0007737)2.18094916
84Femoral bowing (HP:0002980)2.15121006
85Abnormality of glutamine family amino acid metabolism (HP:0010902)2.14885437
86Abnormality of the gastric mucosa (HP:0004295)2.14846550
87Abnormality of the acetabulum (HP:0003170)2.14508111
88Joint stiffness (HP:0001387)2.14036347
89Overgrowth (HP:0001548)2.13770951
90Pulmonic stenosis (HP:0001642)2.13116476
91Flat capital femoral epiphysis (HP:0003370)2.11289190
92Hypoplasia of the odontoid process (HP:0003311)2.07062106
93Mitral stenosis (HP:0001718)2.06098981
94Broad ribs (HP:0000885)2.05939252
95Mitral valve prolapse (HP:0001634)2.05783421
96Aortic dissection (HP:0002647)2.04419255
97Increased variability in muscle fiber diameter (HP:0003557)2.03844671
98Aplasia/Hypoplasia of the hallux (HP:0008362)2.03519970
99Limb-girdle muscle weakness (HP:0003325)2.02094779
100Posterior embryotoxon (HP:0000627)2.00774832
101Hallux valgus (HP:0001822)2.00057367
102Delayed cranial suture closure (HP:0000270)1.99333823
103Cardiovascular calcification (HP:0011915)1.98072315
104Abnormality of the distal phalanges of the toes (HP:0010182)1.96862397
105Glossoptosis (HP:0000162)1.96704926
106Trismus (HP:0000211)1.96301757
107Hypochromic microcytic anemia (HP:0004840)1.95866246
108Aortic aneurysm (HP:0004942)1.95296393
109Infantile muscular hypotonia (HP:0008947)1.94958050
110Hydroureter (HP:0000072)1.94776925
111Nonimmune hydrops fetalis (HP:0001790)1.93400444
112Ankyloglossia (HP:0010296)1.92294186
113Mesomelia (HP:0003027)1.91648865
114Abnormality of the odontoid process (HP:0003310)1.91538141
115Epiphyseal dysplasia (HP:0002656)1.90926270
116Camptodactyly of toe (HP:0001836)1.88359872
117Hip contracture (HP:0003273)1.87976100
118Multiple enchondromatosis (HP:0005701)1.87758167
119Round ear (HP:0100830)1.87110528
120Abnormality of the line of Schwalbe (HP:0008048)1.86772771
121Periorbital edema (HP:0100539)1.85821866
122Patellar dislocation (HP:0002999)1.85174341
123Aplasia of the musculature (HP:0100854)1.82136441
124Generalized amyotrophy (HP:0003700)1.81706537
125Congenital glaucoma (HP:0001087)1.81071767
126Narrow nasal bridge (HP:0000446)1.80519041
127Upper limb muscle weakness (HP:0003484)1.79896044
128Abnormality of the fetal cardiovascular system (HP:0010948)1.79805215
129Abnormal umbilical cord blood vessels (HP:0011403)1.79805215
130Single umbilical artery (HP:0001195)1.79805215
131Morphological abnormality of the middle ear (HP:0008609)1.79497425
132Cerebral aneurysm (HP:0004944)1.78588882
133Osteoarthritis (HP:0002758)1.77178754
134Increased connective tissue (HP:0009025)1.76027895
135Bulbous nose (HP:0000414)1.75854333
136Facial edema (HP:0000282)1.75011375
137Tarsal synostosis (HP:0008368)1.74917954
138Limited hip movement (HP:0008800)1.74797107
139Dilatation of the ascending aorta (HP:0005111)1.74793141
140Distal lower limb amyotrophy (HP:0008944)1.72440124
141Bradycardia (HP:0001662)1.71809232
142Vertebral arch anomaly (HP:0008438)1.71239571
143Buphthalmos (HP:0000557)1.70929864
144Upper limb amyotrophy (HP:0009129)1.70357817
145Distal upper limb amyotrophy (HP:0007149)1.70357817
146Mesangial abnormality (HP:0001966)1.70137596
147Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.67884512
148Thoracolumbar scoliosis (HP:0002944)1.67614437
149Ankle contracture (HP:0006466)1.67458944
150Abnormality of the pulmonary veins (HP:0011718)1.67369341
151Premature skin wrinkling (HP:0100678)1.65947146
152Mildly elevated creatine phosphokinase (HP:0008180)1.65826750
153Abnormality of the lumbar spine (HP:0100712)1.65636733
154Disproportionate short-trunk short stature (HP:0003521)1.65466766
155Humeroradial synostosis (HP:0003041)1.65082865
156Synostosis involving the elbow (HP:0003938)1.65082865
157Abnormality of dentin (HP:0010299)1.64911200
158Abnormality of the middle phalanges of the toes (HP:0010183)1.64537626
159Peritonitis (HP:0002586)1.64529357
160Aneurysm (HP:0002617)1.63494275
161Enlarged penis (HP:0000040)1.63338545
162Widely patent fontanelles and sutures (HP:0004492)1.60785560
163Spinal rigidity (HP:0003306)1.59222080

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BMX5.74368230
2ACVR1B4.98249225
3MYLK4.91379566
4NME14.88142132
5MAP3K24.86584338
6MAP3K43.80864080
7MAP3K143.25472061
8CDK123.10430065
9TGFBR22.87467654
10PRKD22.35718339
11MAP3K72.29788331
12STK382.26327121
13EPHB22.13953541
14FRK2.12790802
15INSRR2.09665952
16AKT32.01947397
17MAP3K131.97755031
18PINK11.94714119
19BMPR1B1.87246068
20PAK21.80095385
21RIPK41.79317765
22PIK3CG1.77387010
23BCR1.73703116
24DDR21.73527821
25FGR1.71324786
26MAP3K121.62345129
27PAK31.54090774
28LATS21.52452443
29NUAK11.48762751
30DMPK1.48088627
31EPHA41.43518482
32PNCK1.37687793
33MAPKAPK31.36947423
34WNK11.36822348
35GRK51.35077646
36FLT31.33740821
37STK38L1.32511148
38PTK2B1.32384479
39WNK41.29328525
40ERN11.26358793
41PIM21.26124623
42TRPM71.23614927
43TESK11.22873019
44CDK81.17289792
45NEK91.11972746
46MOS1.09414904
47STK31.08659680
48KSR21.04902252
49TGFBR11.04738607
50CASK1.03091025
51JAK31.01882977
52KIT1.00415153
53MET1.00018597
54PDGFRB0.96508160
55PRKG20.93752453
56MAPK130.89547055
57SIK10.89483632
58PAK60.87155075
59PRKCH0.86608854
60BMPR20.85046488
61DAPK30.84949482
62MAP3K30.84657568
63LIMK10.83501293
64MARK10.80162956
65EIF2AK20.79121117
66NME20.77797173
67GRK60.77289894
68GRK70.76176423
69RIPK10.71798496
70MAPK70.71100076
71MAP4K20.70110131
72STK160.70029528
73STK100.68410244
74HIPK20.66656477
75FGFR10.66453375
76MAP2K70.66409027
77NTRK20.66029588
78JAK10.64922545
79ROCK20.64486204
80DYRK1A0.64459310
81MKNK20.62603721
82LRRK20.62539337
83PAK40.61690108
84MUSK0.61346021
85TTN0.60695679
86PRKCD0.59541089
87MAPKAPK20.59264789
88ADRBK20.58148204
89PRKCQ0.57359456
90CAMKK20.56626478
91ERBB40.56624682
92CDK70.55627198
93EGFR0.55537131
94PRKCG0.53935552
95PRKD30.53700381
96GSK3A0.53573302
97CAMK2G0.52782767
98PBK0.52687712
99MAP2K20.52442601
100MKNK10.52392121
101PDGFRA0.51641117
102ADRBK10.49647493
103CDC42BPA0.49065287
104TNIK0.48638602
105MAPK110.47090416
106ABL20.47023302
107CDK50.46761626
108LMTK20.46733586
109NTRK10.46721384
110PLK20.46510119
111CAMK10.45851786
112MAPKAPK50.45675778
113TAOK30.45310466
114TBK10.44333718
115DYRK30.43165707
116IKBKB0.42851235
117RPS6KA20.41409211
118WNK30.40961340
119MELK0.40837803
120FYN0.40014236
121GRK10.39989427
122PIK3CA0.39356789
123PTK20.38614175
124CDK60.38480363
125PRKD10.37807273
126EPHA30.36673706
127INSR0.36552774
128CAMK2D0.34038667
129SRC0.33187708
130RAF10.32736040
131LATS10.32207317
132PRKCE0.32122516
133CAMK2A0.32065684
134MAPK150.31606735
135CHUK0.31212429
136IRAK30.30968397
137CSNK1G20.29908726
138IGF1R0.29668288
139CSNK1D0.29442368
140TIE10.29065898
141PDK20.27980760
142EPHB10.27469290
143CSNK1E0.26200171
144MINK10.25897208
145CDK140.25570630
146STK110.24695636
147ILK0.23333792
148CDK150.23226383
149MAP3K10.22472627
150DYRK1B0.22184587
151MAPK30.22141589
152MAPK40.22120689
153MAP2K10.21268780
154MAPK140.20919167
155MATK0.20814751
156ROCK10.20012076
157PRKCA0.19867707

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein digestion and absorption_Homo sapiens_hsa049743.79664752
2SNARE interactions in vesicular transport_Homo sapiens_hsa041303.46987304
3Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.40242964
4Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.28107445
5Chemical carcinogenesis_Homo sapiens_hsa052043.01531631
6Glycosaminoglycan degradation_Homo sapiens_hsa005312.74171272
7ECM-receptor interaction_Homo sapiens_hsa045122.57108759
8Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.17631727
9AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.14103479
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.13142429
11Malaria_Homo sapiens_hsa051442.04745060
12Glutathione metabolism_Homo sapiens_hsa004801.99564775
13Hedgehog signaling pathway_Homo sapiens_hsa043401.90500658
14TGF-beta signaling pathway_Homo sapiens_hsa043501.87046787
15Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.74993712
16Rheumatoid arthritis_Homo sapiens_hsa053231.71050499
17Sulfur metabolism_Homo sapiens_hsa009201.69810379
18* Complement and coagulation cascades_Homo sapiens_hsa046101.59760253
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.59024150
20Protein export_Homo sapiens_hsa030601.56559364
21Legionellosis_Homo sapiens_hsa051341.55381425
22Vitamin B6 metabolism_Homo sapiens_hsa007501.54299789
23Amoebiasis_Homo sapiens_hsa051461.48531089
24Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.48234691
25Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.41524374
26Leishmaniasis_Homo sapiens_hsa051401.39770592
27Dilated cardiomyopathy_Homo sapiens_hsa054141.38481800
28Staphylococcus aureus infection_Homo sapiens_hsa051501.34243643
29GnRH signaling pathway_Homo sapiens_hsa049121.34019176
30TNF signaling pathway_Homo sapiens_hsa046681.31967091
31Osteoclast differentiation_Homo sapiens_hsa043801.31466398
32Proteoglycans in cancer_Homo sapiens_hsa052051.30840877
33Selenocompound metabolism_Homo sapiens_hsa004501.30627397
34Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.26512121
35Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.26128536
36PI3K-Akt signaling pathway_Homo sapiens_hsa041511.24416767
37Focal adhesion_Homo sapiens_hsa045101.19439848
38Melanogenesis_Homo sapiens_hsa049161.18749261
39Melanoma_Homo sapiens_hsa052181.18666783
40Phototransduction_Homo sapiens_hsa047441.18500363
41Type I diabetes mellitus_Homo sapiens_hsa049401.18187996
42Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.17541267
43Graft-versus-host disease_Homo sapiens_hsa053321.16840845
44Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.16681396
45Pentose and glucuronate interconversions_Homo sapiens_hsa000401.16224781
46Lysine degradation_Homo sapiens_hsa003101.15995089
47Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.15261865
48Mineral absorption_Homo sapiens_hsa049781.14718162
49HIF-1 signaling pathway_Homo sapiens_hsa040661.13586255
50mTOR signaling pathway_Homo sapiens_hsa041501.12749557
51Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.11320460
52N-Glycan biosynthesis_Homo sapiens_hsa005101.09686499
53Basal cell carcinoma_Homo sapiens_hsa052171.04331879
54* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.01022230
55African trypanosomiasis_Homo sapiens_hsa051431.00515999
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.00329384
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.98759126
58Bladder cancer_Homo sapiens_hsa052190.98312734
59Axon guidance_Homo sapiens_hsa043600.96818375
60Rap1 signaling pathway_Homo sapiens_hsa040150.94733801
61MAPK signaling pathway_Homo sapiens_hsa040100.94144028
62* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.92575764
63Vibrio cholerae infection_Homo sapiens_hsa051100.92100338
64Galactose metabolism_Homo sapiens_hsa000520.91612076
65Circadian entrainment_Homo sapiens_hsa047130.91333255
66Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.91152431
67Ras signaling pathway_Homo sapiens_hsa040140.89906364
68Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.88950405
69Allograft rejection_Homo sapiens_hsa053300.87579403
70Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.86484844
71Prion diseases_Homo sapiens_hsa050200.84711532
72Taste transduction_Homo sapiens_hsa047420.84504497
73p53 signaling pathway_Homo sapiens_hsa041150.83466304
74Hippo signaling pathway_Homo sapiens_hsa043900.82524928
75Tryptophan metabolism_Homo sapiens_hsa003800.82505350
76Basal transcription factors_Homo sapiens_hsa030220.81917237
77NOD-like receptor signaling pathway_Homo sapiens_hsa046210.81233299
78* Pathways in cancer_Homo sapiens_hsa052000.81076119
79Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.80606202
80* Calcium signaling pathway_Homo sapiens_hsa040200.79732527
81Amphetamine addiction_Homo sapiens_hsa050310.79225126
82Adherens junction_Homo sapiens_hsa045200.77941254
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.75826951
84Circadian rhythm_Homo sapiens_hsa047100.74647264
85cGMP-PKG signaling pathway_Homo sapiens_hsa040220.73217400
86Lysosome_Homo sapiens_hsa041420.72999665
87NF-kappa B signaling pathway_Homo sapiens_hsa040640.72834235
88Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.72537916
89Dorso-ventral axis formation_Homo sapiens_hsa043200.69879004
90cAMP signaling pathway_Homo sapiens_hsa040240.69864269
91Glutamatergic synapse_Homo sapiens_hsa047240.69034233
92Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.66214176
93Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.65962855
94Starch and sucrose metabolism_Homo sapiens_hsa005000.64575272
95Phospholipase D signaling pathway_Homo sapiens_hsa040720.63736324
96Sphingolipid metabolism_Homo sapiens_hsa006000.63265805
97Apoptosis_Homo sapiens_hsa042100.63162943
98Primary bile acid biosynthesis_Homo sapiens_hsa001200.62874536
99alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.62774819
100Pertussis_Homo sapiens_hsa051330.61955838
101Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.61499527
102Vascular smooth muscle contraction_Homo sapiens_hsa042700.60600863
103Regulation of autophagy_Homo sapiens_hsa041400.60145892
104Toll-like receptor signaling pathway_Homo sapiens_hsa046200.59117111
105Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.59079027
106Cholinergic synapse_Homo sapiens_hsa047250.59061440
107Gap junction_Homo sapiens_hsa045400.59042131
108Platelet activation_Homo sapiens_hsa046110.58081428
109Other glycan degradation_Homo sapiens_hsa005110.55941345
110Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.54170536
111Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53638588
112Oxytocin signaling pathway_Homo sapiens_hsa049210.53518290
113GABAergic synapse_Homo sapiens_hsa047270.53223630
114Ovarian steroidogenesis_Homo sapiens_hsa049130.52227022
115Tight junction_Homo sapiens_hsa045300.52195818
116Linoleic acid metabolism_Homo sapiens_hsa005910.50568041
117Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48930805
118Thyroid hormone synthesis_Homo sapiens_hsa049180.47695199
119HTLV-I infection_Homo sapiens_hsa051660.46248699
120Insulin secretion_Homo sapiens_hsa049110.46233463
121Central carbon metabolism in cancer_Homo sapiens_hsa052300.45372208
122Prostate cancer_Homo sapiens_hsa052150.44872409
123Arginine biosynthesis_Homo sapiens_hsa002200.44592438
124Olfactory transduction_Homo sapiens_hsa047400.43384751
125Morphine addiction_Homo sapiens_hsa050320.43065282
126Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.41981919
127Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.41422065
128Caffeine metabolism_Homo sapiens_hsa002320.40540715
129Renin secretion_Homo sapiens_hsa049240.40502009
130Cyanoamino acid metabolism_Homo sapiens_hsa004600.40196006
131Wnt signaling pathway_Homo sapiens_hsa043100.39785768
132Nitrogen metabolism_Homo sapiens_hsa009100.39694281
133Arachidonic acid metabolism_Homo sapiens_hsa005900.39578954
134Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36977399
135Long-term depression_Homo sapiens_hsa047300.36872861
136PPAR signaling pathway_Homo sapiens_hsa033200.36857777
137Aldosterone synthesis and secretion_Homo sapiens_hsa049250.36790500
138Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36595847
139Cocaine addiction_Homo sapiens_hsa050300.36519769
140FoxO signaling pathway_Homo sapiens_hsa040680.36107382
141Ether lipid metabolism_Homo sapiens_hsa005650.35585273
142Small cell lung cancer_Homo sapiens_hsa052220.35537385
143Tuberculosis_Homo sapiens_hsa051520.34433649
144Salivary secretion_Homo sapiens_hsa049700.33919072
145* Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.33711586
146Chemokine signaling pathway_Homo sapiens_hsa040620.31081492
147MicroRNAs in cancer_Homo sapiens_hsa052060.30808940

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