BCL2L1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protoporphyrinogen IX metabolic process (GO:0046501)5.10177595
2* modulation by virus of host process (GO:0019054)4.95335652
3* modulation by symbiont of host cellular process (GO:0044068)4.65369804
4sequestering of actin monomers (GO:0042989)4.57615606
5hemoglobin metabolic process (GO:0020027)4.56172694
6oxygen transport (GO:0015671)4.50988602
7protoporphyrinogen IX biosynthetic process (GO:0006782)4.15560195
8pyrimidine nucleobase catabolic process (GO:0006208)4.05486250
9gas transport (GO:0015669)4.01939453
10barbed-end actin filament capping (GO:0051016)4.00329444
11myelin maintenance (GO:0043217)3.74929328
12phosphorelay signal transduction system (GO:0000160)3.72406131
13very-low-density lipoprotein particle assembly (GO:0034379)3.55999949
14erythrocyte maturation (GO:0043249)3.52663122
15regulation of podosome assembly (GO:0071801)3.50349545
16positive regulation of Cdc42 GTPase activity (GO:0043089)3.46117377
17spinal cord development (GO:0021510)3.42865887
18Golgi transport vesicle coating (GO:0048200)3.42163054
19COPI coating of Golgi vesicle (GO:0048205)3.42163054
20protein localization to endosome (GO:0036010)3.35694994
21neurofilament cytoskeleton organization (GO:0060052)3.33825367
22cellular response to prostaglandin stimulus (GO:0071379)3.33358428
23Rap protein signal transduction (GO:0032486)3.32222588
24regulation of early endosome to late endosome transport (GO:2000641)3.25055594
25regulation of protein targeting to membrane (GO:0090313)3.24753464
26negative regulation of necroptotic process (GO:0060546)3.23311981
273-UTR-mediated mRNA stabilization (GO:0070935)3.22775018
28regulation of necroptotic process (GO:0060544)3.21928220
29positive regulation of receptor recycling (GO:0001921)3.19811969
30negative regulation of erythrocyte differentiation (GO:0045647)3.17939032
31porphyrin-containing compound biosynthetic process (GO:0006779)3.15320569
32hypotonic response (GO:0006971)3.14573572
33positive regulation of protein homooligomerization (GO:0032464)3.11101212
34regulation of response to osmotic stress (GO:0047484)3.08025185
35plasma lipoprotein particle assembly (GO:0034377)3.07838975
36pinocytosis (GO:0006907)3.06963459
37nucleobase catabolic process (GO:0046113)3.04307959
38regulation of hippo signaling (GO:0035330)3.03070125
39low-density lipoprotein particle clearance (GO:0034383)3.00543676
40negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.99588713
41regulation of G0 to G1 transition (GO:0070316)2.97194166
42neutrophil activation involved in immune response (GO:0002283)2.95042087
43regulation of platelet aggregation (GO:0090330)2.94684118
44response to lipoprotein particle (GO:0055094)2.94349746
45protein-lipid complex assembly (GO:0065005)2.93864342
46regulation of NFAT protein import into nucleus (GO:0051532)2.92947820
47positive regulation of extracellular matrix organization (GO:1903055)2.92719685
48cytoskeletal anchoring at plasma membrane (GO:0007016)2.92527333
49cortical actin cytoskeleton organization (GO:0030866)2.88914917
50regulation of cholesterol homeostasis (GO:2000188)2.85750741
51activation of MAPKKK activity (GO:0000185)2.85395341
52actin filament capping (GO:0051693)2.85098553
53stress fiber assembly (GO:0043149)2.83642625
54central nervous system myelination (GO:0022010)2.83332772
55axon ensheathment in central nervous system (GO:0032291)2.83332772
56response to nerve growth factor (GO:1990089)2.77780886
57cellular response to nerve growth factor stimulus (GO:1990090)2.77780886
58protein insertion into membrane (GO:0051205)2.76600609
59regulation of extracellular matrix disassembly (GO:0010715)2.75092246
60glial cell proliferation (GO:0014009)2.74269255
61nerve growth factor signaling pathway (GO:0038180)2.73506079
62embryonic process involved in female pregnancy (GO:0060136)2.73336811
63negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.71568309
64positive regulation by organism of defense response of other organism involved in symbiotic interact2.69384613
65modulation by symbiont of host immune response (GO:0052553)2.69384613
66positive regulation by symbiont of host defense response (GO:0052509)2.69384613
67modulation by symbiont of host defense response (GO:0052031)2.69384613
68modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.69384613
69modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.69384613
70regulation of superoxide anion generation (GO:0032928)2.69025856
71negative regulation of microtubule polymerization (GO:0031115)2.68313597
72antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.68299434
73positive regulation of insulin receptor signaling pathway (GO:0046628)2.67744487
74myeloid cell development (GO:0061515)2.67152310
75morphogenesis of an endothelium (GO:0003159)2.67043708
76endothelial tube morphogenesis (GO:0061154)2.67043708
77negative regulation of fibrinolysis (GO:0051918)2.65410407
78amyloid precursor protein catabolic process (GO:0042987)2.65372587
79cortical cytoskeleton organization (GO:0030865)2.64879287
80ganglion development (GO:0061548)2.64734421
81positive regulation of type 2 immune response (GO:0002830)2.63970351
82protein-DNA complex disassembly (GO:0032986)2.63593058
83nucleosome disassembly (GO:0006337)2.63593058
84regulation of metalloenzyme activity (GO:0048552)2.62635343
85porphyrin-containing compound metabolic process (GO:0006778)2.62396800
86negative regulation of Ras GTPase activity (GO:0034261)2.59998498
87positive regulation of cellular response to insulin stimulus (GO:1900078)2.59568642
88negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.59540975
89negative regulation of cell killing (GO:0031342)2.59540975
90positive regulation of hemostasis (GO:1900048)2.59385157
91positive regulation of blood coagulation (GO:0030194)2.59385157
92negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.57856058
93response to methylmercury (GO:0051597)2.57671049
94skin morphogenesis (GO:0043589)2.56398764
95* extrinsic apoptotic signaling pathway in absence of ligand (GO:0097192)2.55592012
96* signal transduction in absence of ligand (GO:0038034)2.55592012
97negative regulation of adherens junction organization (GO:1903392)2.55478719
98negative regulation of focal adhesion assembly (GO:0051895)2.55478719
99negative regulation of cell junction assembly (GO:1901889)2.55478719
100cell volume homeostasis (GO:0006884)2.54371575
101tetrapyrrole biosynthetic process (GO:0033014)2.54362985
102pentose-phosphate shunt (GO:0006098)2.54220740
103synaptic vesicle maturation (GO:0016188)2.53297025
104iron ion import (GO:0097286)2.52788967
105regulation of necrotic cell death (GO:0010939)2.52337446
106protein targeting to plasma membrane (GO:0072661)2.52332586
107regulation of ARF GTPase activity (GO:0032312)2.51723474
108mesodermal cell differentiation (GO:0048333)2.51675467
109peptidyl-glutamic acid carboxylation (GO:0017187)2.50634790
110protein carboxylation (GO:0018214)2.50634790
111positive regulation of protein targeting to membrane (GO:0090314)2.50397282
112heme metabolic process (GO:0042168)2.50306717
113response to acidic pH (GO:0010447)2.50089630
114activation of Rac GTPase activity (GO:0032863)2.49747319
115* modulation by virus of host morphology or physiology (GO:0019048)2.48561104
116negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.47493025
117heme biosynthetic process (GO:0006783)2.47186946
118positive regulation of coagulation (GO:0050820)2.46509121
119negative regulation of necrotic cell death (GO:0060547)2.46336761
120regulation of leukocyte degranulation (GO:0043300)2.46325289
121regulation of extracellular matrix organization (GO:1903053)2.45985643
122antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.44949445
123adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.44228630
124membrane protein intracellular domain proteolysis (GO:0031293)2.43859302
125regulation of receptor recycling (GO:0001919)2.42262557
126cellular response to nicotine (GO:0071316)2.41606800
127receptor recycling (GO:0001881)2.41194937
128response to peptidoglycan (GO:0032494)2.40678612
129positive regulation of fibroblast migration (GO:0010763)2.40528465
130negative regulation of peptidyl-serine phosphorylation (GO:0033137)2.40521416
131regulation of myeloid leukocyte mediated immunity (GO:0002886)2.40282573
132positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.40052726
133cell-substrate junction assembly (GO:0007044)2.39986190
134signal complex assembly (GO:0007172)2.39901682
135actin filament depolymerization (GO:0030042)2.39689549
136glucose 6-phosphate metabolic process (GO:0051156)2.39416756
137glycine transport (GO:0015816)2.37340981
138negative regulation of protein polymerization (GO:0032272)2.36622000
139antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.36302941
140actin filament bundle assembly (GO:0051017)2.36064556
141actin filament bundle organization (GO:0061572)2.36064556
142calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.34744163
143megakaryocyte development (GO:0035855)2.33612200
144retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.33334677
145positive regulation of actin filament depolymerization (GO:0030836)2.33002090
146decidualization (GO:0046697)2.31200628
147response to lead ion (GO:0010288)2.31156752
148layer formation in cerebral cortex (GO:0021819)2.30600228
149lipopolysaccharide-mediated signaling pathway (GO:0031663)2.29752651
150negative regulation of actin filament polymerization (GO:0030837)2.29652298
151regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.29189775
152negative regulation of actin filament depolymerization (GO:0030835)2.28677047
153regulation of amyloid precursor protein catabolic process (GO:1902991)2.28215402
154response to prostaglandin E (GO:0034695)2.28109923
155regulation of protein homooligomerization (GO:0032462)2.28027743
156positive regulation of macroautophagy (GO:0016239)2.27675809
157glucose catabolic process (GO:0006007)2.27280118
158response to laminar fluid shear stress (GO:0034616)2.27005176
159membrane protein ectodomain proteolysis (GO:0006509)2.26263480
160glycerophospholipid catabolic process (GO:0046475)2.26035903
161proline biosynthetic process (GO:0006561)2.25485961
162positive regulation of macrophage differentiation (GO:0045651)2.25205163
163cellular response to glucagon stimulus (GO:0071377)2.24930632
164limb bud formation (GO:0060174)2.24107845
165import into cell (GO:0098657)2.24003322
166cell migration in hindbrain (GO:0021535)2.23964264
167GDP-mannose metabolic process (GO:0019673)2.23654742
168positive regulation of gamma-delta T cell activation (GO:0046645)2.23355595
169regulation of mast cell degranulation (GO:0043304)2.23200274
170antigen processing and presentation of endogenous antigen (GO:0019883)2.23144934
171cellular hyperosmotic response (GO:0071474)2.23007056
172regulation of defense response to virus by virus (GO:0050690)2.22981468
173semaphorin-plexin signaling pathway (GO:0071526)2.21249461
174erythrocyte development (GO:0048821)2.19991684
175negative regulation of toll-like receptor signaling pathway (GO:0034122)2.18148736
176regulation of interleukin-13 production (GO:0032656)2.18079675
177regulation of actin filament depolymerization (GO:0030834)2.16659468
178positive regulation of axonogenesis (GO:0050772)2.15387938
179negative regulation of skeletal muscle tissue development (GO:0048642)2.14743191
180protein K11-linked deubiquitination (GO:0035871)2.14382629

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.41200611
2THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.32973848
3* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.87964531
4GATA1_19941826_ChIP-Seq_K562_Human2.64221788
5STAT6_21828071_ChIP-Seq_BEAS2B_Human2.61768431
6KDM2B_26808549_Chip-Seq_K562_Human2.57776676
7KDM2B_26808549_Chip-Seq_SUP-B15_Human2.48875635
8* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.32900310
9ZNF263_19887448_ChIP-Seq_K562_Human2.24264028
10MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.21757937
11VDR_21846776_ChIP-Seq_THP-1_Human2.16544147
12RARG_19884340_ChIP-ChIP_MEFs_Mouse2.14082442
13TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.07575787
14ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.06521035
15ZFP281_18757296_ChIP-ChIP_E14_Mouse2.00926818
16MYB_21317192_ChIP-Seq_ERMYB_Mouse1.99841583
17NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.98761483
18KDM2B_26808549_Chip-Seq_DND41_Human1.98438499
19* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.91425458
20* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.89638842
21EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.82856857
22GATA1_22025678_ChIP-Seq_K562_Human1.81695150
23SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.80480447
24KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.80132558
25* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.80005352
26* GATA1_19941827_ChIP-Seq_MEL_Mouse1.77076895
27KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.75230981
28ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.75109879
29BRD4_27068464_Chip-Seq_AML-cells_Mouse1.70848095
30EGR1_19374776_ChIP-ChIP_THP-1_Human1.69512797
31GATA1_22383799_ChIP-Seq_G1ME_Mouse1.65849756
32CLOCK_20551151_ChIP-Seq_293T_Human1.65267837
33ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.64202610
34KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.62947680
35VDR_24763502_ChIP-Seq_THP-1_Human1.62716915
36GATA1_26923725_Chip-Seq_HPCs_Mouse1.62249509
37RUNX1_22412390_ChIP-Seq_EML_Mouse1.62197970
38MAF_26560356_Chip-Seq_TH1_Human1.61762637
39* RXR_22158963_ChIP-Seq_LIVER_Mouse1.60805263
40NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.60143633
41ERG_21242973_ChIP-ChIP_JURKAT_Human1.57617693
42TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56533454
43* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.55207624
44SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.54687915
45TRIM28_21343339_ChIP-Seq_HEK293_Human1.54553119
46NCOR1_26117541_ChIP-Seq_K562_Human1.54115990
47EZH2_22144423_ChIP-Seq_EOC_Human1.53116561
48* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.51180972
49* GATA2_19941826_ChIP-Seq_K562_Human1.49979115
50TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.49258366
51* SPI1_23127762_ChIP-Seq_K562_Human1.48949325
52* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.47589116
53ATF3_27146783_Chip-Seq_COLON_Human1.46532084
54KDM2B_26808549_Chip-Seq_JURKAT_Human1.45116668
55TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.44994263
56SUZ12_27294783_Chip-Seq_ESCs_Mouse1.44524047
57EZH2_27294783_Chip-Seq_ESCs_Mouse1.44433806
58ZFP281_27345836_Chip-Seq_ESCs_Mouse1.44418381
59KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.44160949
60BCOR_27268052_Chip-Seq_Bcells_Human1.43089048
61LXR_22292898_ChIP-Seq_THP-1_Human1.41126473
62ELK3_25401928_ChIP-Seq_HUVEC_Human1.40235200
63* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.39248883
64TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38502490
65SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.36653501
66GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.36088569
67UTX_26944678_Chip-Seq_JUKART_Human1.35128113
68DNAJC2_21179169_ChIP-ChIP_NT2_Human1.34727149
69ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.34550880
70SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.34220990
71* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.33567240
72RNF2_27304074_Chip-Seq_ESCs_Mouse1.32899686
73MYC_22102868_ChIP-Seq_BL_Human1.32743928
74RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.32660132
75Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.31093988
76OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.30571377
77* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.30533649
78P300_27058665_Chip-Seq_ZR-75-30cells_Human1.30098958
79* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.29959287
80NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.29746918
81PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.29386005
82* RACK7_27058665_Chip-Seq_MCF-7_Human1.26634976
83EZH2_18974828_ChIP-Seq_MESCs_Mouse1.25316304
84RNF2_18974828_ChIP-Seq_MESCs_Mouse1.25316304
85CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.25221737
86ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.25172036
87* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.23728321
88* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.21747224
89PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.21049030
90NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.20333852
91FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.20260980
92* RARB_27405468_Chip-Seq_BRAIN_Mouse1.20122491
93GATA2_21666600_ChIP-Seq_HMVEC_Human1.19696194
94IRF8_27001747_Chip-Seq_BMDM_Mouse1.19506008
95* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.18658876
96ESR2_21235772_ChIP-Seq_MCF-7_Human1.18237893
97GATA2_22383799_ChIP-Seq_G1ME_Mouse1.18125717
98MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.18068260
99WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.17087940
100DROSHA_22980978_ChIP-Seq_HELA_Human1.16487098
101JARID2_20075857_ChIP-Seq_MESCs_Mouse1.15949203
102TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.15841179
103AHR_22903824_ChIP-Seq_MCF-7_Human1.15379275
104ESR1_20079471_ChIP-ChIP_T-47D_Human1.15327384
105* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.14929827
106E2F1_20622854_ChIP-Seq_HELA_Human1.14667393
107* TP53_22127205_ChIP-Seq_IMR90_Human1.13275991
108MTF2_20144788_ChIP-Seq_MESCs_Mouse1.13195787
109BCL6_27268052_Chip-Seq_Bcells_Human1.12606398
110STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.12416788
111MAF_26560356_Chip-Seq_TH2_Human1.11631260
112PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11307166
113IRF8_22096565_ChIP-ChIP_GC-B_Human1.11102521
114TCF7_22412390_ChIP-Seq_EML_Mouse1.11047733
115TP53_20018659_ChIP-ChIP_R1E_Mouse1.10003279
116HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.09826923
117TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07673119
118* FOXO3_23340844_ChIP-Seq_DLD1_Human1.07308299
119CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.06996686
120SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.06952324
121SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.06952324
122KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.06160478
123* LXR_22158963_ChIP-Seq_LIVER_Mouse1.05933612
124FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.05826987
125RING1B_27294783_Chip-Seq_NPCs_Mouse1.05741869
126ELF1_20517297_ChIP-Seq_JURKAT_Human1.05660373
127FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.05458808
128REST_18959480_ChIP-ChIP_MESCs_Mouse1.04818294
129KLF4_18555785_ChIP-Seq_MESCs_Mouse1.04463276
130* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.04289673
131SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.03969335
132SMC4_20622854_ChIP-Seq_HELA_Human1.03495007
133TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03482763
134SRY_22984422_ChIP-ChIP_TESTIS_Rat1.03274263
135MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.03263848
136P68_20966046_ChIP-Seq_HELA_Human1.02807735
137* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02395532
138* TP53_23651856_ChIP-Seq_MEFs_Mouse1.02376317
139CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.01876668
140SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.01745322
141SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.01207997
142* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01189585
143* SPI1_23547873_ChIP-Seq_NB4_Human1.00460825
144STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.00129020
145IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.99923518
146CTCF_27219007_Chip-Seq_Bcells_Human0.99787553
147* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.98087567
148CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97571064
149TP63_17297297_ChIP-ChIP_HaCaT_Human0.97247308
150UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.96792841
151PHF8_20622854_ChIP-Seq_HELA_Human0.96486801
152* CREB1_26743006_Chip-Seq_LNCaP_Human0.96318367
153SCL_19346495_ChIP-Seq_HPC-7_Human0.94806379
154DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.94512858
155ELK4_26923725_Chip-Seq_MESODERM_Mouse0.94042529
156TET1_21490601_ChIP-Seq_MESCs_Mouse0.93722743
157JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92245834
158* KLF5_25053715_ChIP-Seq_YYC3_Human0.92158895
159CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.91236181
160RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.90251747
161GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89856403
162VDR_24787735_ChIP-Seq_THP-1_Human0.89052300
163* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.88324797

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003656_abnormal_erythrocyte_physiolo5.24721922
2MP0002653_abnormal_ependyma_morphology4.66703594
3MP0008789_abnormal_olfactory_epithelium4.18947702
4MP0005394_taste/olfaction_phenotype3.87497484
5MP0005499_abnormal_olfactory_system3.87497484
6MP0005451_abnormal_body_composition3.85666379
7MP0008260_abnormal_autophagy3.26439844
8MP0004859_abnormal_synaptic_plasticity2.76643017
9* MP0005464_abnormal_platelet_physiology2.68357489
10MP0001984_abnormal_olfaction2.48742744
11MP0009840_abnormal_foam_cell2.42640894
12MP0003172_abnormal_lysosome_physiology2.42518758
13MP0003705_abnormal_hypodermis_morpholog2.39933820
14MP0005623_abnormal_meninges_morphology2.39019684
15MP0004270_analgesia2.28433712
16MP0004858_abnormal_nervous_system2.23337003
17MP0005377_hearing/vestibular/ear_phenot2.15204572
18MP0003878_abnormal_ear_physiology2.15204572
19MP0000778_abnormal_nervous_system2.02747228
20MP0000920_abnormal_myelination2.01231103
21MP0004947_skin_inflammation1.95501907
22MP0003303_peritoneal_inflammation1.95233255
23MP0003329_amyloid_beta_deposits1.93885688
24MP0000015_abnormal_ear_pigmentation1.80322762
25MP0000604_amyloidosis1.68789877
26MP0003191_abnormal_cellular_cholesterol1.64379023
27MP0004885_abnormal_endolymph1.63287752
28MP0004782_abnormal_surfactant_physiolog1.62366381
29MP0004185_abnormal_adipocyte_glucose1.58058217
30MP0004147_increased_porphyrin_level1.57088038
31MP0005410_abnormal_fertilization1.54647696
32MP0005076_abnormal_cell_differentiation1.53460553
33MP0005025_abnormal_response_to1.52283276
34MP0005645_abnormal_hypothalamus_physiol1.51689370
35MP0003724_increased_susceptibility_to1.51621415
36MP0001958_emphysema1.51547036
37MP0002419_abnormal_innate_immunity1.51524162
38MP0001545_abnormal_hematopoietic_system1.50466893
39MP0005397_hematopoietic_system_phenotyp1.50466893
40MP0003634_abnormal_glial_cell1.46249305
41MP0004264_abnormal_extraembryonic_tissu1.45901708
42MP0001348_abnormal_lacrimal_gland1.44736049
43MP0002132_abnormal_respiratory_system1.43026344
44MP0010234_abnormal_vibrissa_follicle1.42517904
45MP0006082_CNS_inflammation1.36765552
46MP0005058_abnormal_lysosome_morphology1.35819562
47MP0001346_abnormal_lacrimal_gland1.34648455
48MP0005023_abnormal_wound_healing1.33767257
49MP0001835_abnormal_antigen_presentation1.29958389
50MP0004742_abnormal_vestibular_system1.29770313
51MP0003091_abnormal_cell_migration1.27992204
52MP0003632_abnormal_nervous_system1.27646883
53MP0001533_abnormal_skeleton_physiology1.27385910
54* MP0004811_abnormal_neuron_physiology1.26507418
55MP0009785_altered_susceptibility_to1.21917559
56MP0010155_abnormal_intestine_physiology1.21770854
57MP0002882_abnormal_neuron_morphology1.20002259
58MP0005000_abnormal_immune_tolerance1.19904888
59MP0005409_darkened_coat_color1.19739386
60MP0005083_abnormal_biliary_tract1.19040922
61MP0003300_gastrointestinal_ulcer1.18948733
62MP0002138_abnormal_hepatobiliary_system1.17364989
63MP0001790_abnormal_immune_system1.15005022
64MP0005387_immune_system_phenotype1.15005022
65MP0009333_abnormal_splenocyte_physiolog1.14189583
66* MP0002398_abnormal_bone_marrow1.12879202
67* MP0002152_abnormal_brain_morphology1.12173896
68MP0003763_abnormal_thymus_physiology1.11638663
69MP0002063_abnormal_learning/memory/cond1.11095439
70MP0002160_abnormal_reproductive_system1.10755076
71MP0009278_abnormal_bone_marrow1.10547121
72MP0002734_abnormal_mechanical_nocicepti1.09017233
73MP0004883_abnormal_blood_vessel1.08966637
74MP0002139_abnormal_hepatobiliary_system1.08726588
75MP0002751_abnormal_autonomic_nervous1.08673958
76MP0003690_abnormal_glial_cell1.07287922
77MP0002089_abnormal_postnatal_growth/wei1.07233951
78MP0004808_abnormal_hematopoietic_stem1.06070823
79MP0000685_abnormal_immune_system1.05411631
80MP0005501_abnormal_skin_physiology1.04737822
81MP0002420_abnormal_adaptive_immunity1.04596194
82MP0001819_abnormal_immune_cell1.04140858
83MP0003566_abnormal_cell_adhesion1.04079745
84MP0000609_abnormal_liver_physiology1.02191877
85MP0005621_abnormal_cell_physiology1.01938157
86* MP0003861_abnormal_nervous_system1.01826227
87MP0002722_abnormal_immune_system1.01651169
88MP0002723_abnormal_immune_serum1.00547897
89MP0003828_pulmonary_edema1.00065601
90MP0002332_abnormal_exercise_endurance0.99909673
91MP0003866_abnormal_defecation0.99392432
92MP0002452_abnormal_antigen_presenting0.99247657
93MP0004510_myositis0.99190953
94MP0000343_altered_response_to0.97124205
95MP0001845_abnormal_inflammatory_respons0.95868503
96* MP0002429_abnormal_blood_cell0.95226573
97MP0005360_urolithiasis0.94884950
98MP0002148_abnormal_hypersensitivity_rea0.93796013
99MP0002229_neurodegeneration0.93207086
100MP0000955_abnormal_spinal_cord0.92029706
101MP0003635_abnormal_synaptic_transmissio0.91560627
102MP0001915_intracranial_hemorrhage0.91517626
103MP0002796_impaired_skin_barrier0.90653844
104MP0005310_abnormal_salivary_gland0.89637548
105MP0003221_abnormal_cardiomyocyte_apopto0.89555072
106MP0002405_respiratory_system_inflammati0.89096357
107MP0000716_abnormal_immune_system0.89060822
108MP0001851_eye_inflammation0.89016067
109MP0001800_abnormal_humoral_immune0.88776547
110MP0008469_abnormal_protein_level0.88119051
111MP0000689_abnormal_spleen_morphology0.87910562
112MP0003183_abnormal_peptide_metabolism0.87801267
113MP0009931_abnormal_skin_appearance0.87745672
114MP0005666_abnormal_adipose_tissue0.87109153
115MP0002184_abnormal_innervation0.86936223
116MP0002697_abnormal_eye_size0.85611029
117MP0008569_lethality_at_weaning0.83104660
118MP0002877_abnormal_melanocyte_morpholog0.82618747
119MP0005165_increased_susceptibility_to0.82492231
120MP0008874_decreased_physiological_sensi0.81640472
121MP0003950_abnormal_plasma_membrane0.80836289
122MP0003879_abnormal_hair_cell0.80493819
123MP0002752_abnormal_somatic_nervous0.80141068
124MP0000249_abnormal_blood_vessel0.79408520
125MP0008004_abnormal_stomach_pH0.79164255
126MP0009763_increased_sensitivity_to0.78817384
127MP0001485_abnormal_pinna_reflex0.78343384
128MP0003075_altered_response_to0.78130492
129MP0001849_ear_inflammation0.78130162
130MP0005408_hypopigmentation0.77461205
131MP0005365_abnormal_bile_salt0.77364622
132MP0000490_abnormal_crypts_of0.76718669
133MP0000026_abnormal_inner_ear0.76074610
134MP0000703_abnormal_thymus_morphology0.76010227
135MP0000858_altered_metastatic_potential0.75815922
136MP0003045_fibrosis0.75698071
137MP0002060_abnormal_skin_morphology0.74739787
138MP0002166_altered_tumor_susceptibility0.74662251
139MP0001216_abnormal_epidermal_layer0.73335845
140* MP0002066_abnormal_motor_capabilities/c0.72223715
141MP0000534_abnormal_ureter_morphology0.71945645
142MP0002064_seizures0.71854277
143* MP0003631_nervous_system_phenotype0.70549932
144MP0002272_abnormal_nervous_system0.69943023
145MP0002295_abnormal_pulmonary_circulatio0.69726300
146MP0009765_abnormal_xenobiotic_induced0.69061418
147* MP0003453_abnormal_keratinocyte_physiol0.67830775
148MP0001177_atelectasis0.66242468
149MP0005171_absent_coat_pigmentation0.65626110
150MP0003436_decreased_susceptibility_to0.65605400
151MP0002733_abnormal_thermal_nociception0.64969740
152MP0002557_abnormal_social/conspecific_i0.64383507
153MP0005197_abnormal_uvea_morphology0.62841114
154MP0002572_abnormal_emotion/affect_behav0.62816750
155MP0003448_altered_tumor_morphology0.61067594
156MP0002233_abnormal_nose_morphology0.59887278
157MP0005195_abnormal_posterior_eye0.59092081
158MP0005636_abnormal_mineral_homeostasis0.59055422
159MP0002081_perinatal_lethality0.58854783
160MP0008995_early_reproductive_senescence0.58062556
161MP0010352_gastrointestinal_tract_polyps0.58034928
162MP0005164_abnormal_response_to0.58004924
163MP0003115_abnormal_respiratory_system0.57501796
164MP0010030_abnormal_orbit_morphology0.57372527
165MP0001970_abnormal_pain_threshold0.57010233
166MP0002998_abnormal_bone_remodeling0.56117458
167MP0002177_abnormal_outer_ear0.55765202
168MP0009046_muscle_twitch0.55254689
169MP0003787_abnormal_imprinting0.55018670

Predicted human phenotypes

RankGene SetZ-score
1Poikilocytosis (HP:0004447)3.95056261
2Abnormality of the heme biosynthetic pathway (HP:0010472)3.87124140
3Deep venous thrombosis (HP:0002625)3.83468259
4Menorrhagia (HP:0000132)3.52243640
5Prolonged bleeding time (HP:0003010)3.34680830
6Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.30910826
7Degeneration of the lateral corticospinal tracts (HP:0002314)3.30910826
8Supranuclear gaze palsy (HP:0000605)3.27345524
9Reticulocytosis (HP:0001923)3.26377767
10Insomnia (HP:0100785)3.26269076
11Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.14473754
12Cholelithiasis (HP:0001081)3.11740817
13Abnormal gallbladder morphology (HP:0012437)3.10946942
14Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.03207243
15Gingival bleeding (HP:0000225)3.01332952
16Abnormal auditory evoked potentials (HP:0006958)3.01169559
17Osteomalacia (HP:0002749)3.00031340
18Microcytic anemia (HP:0001935)2.93682471
19Purpura (HP:0000979)2.93331437
20Eczematoid dermatitis (HP:0000976)2.86143001
21Abnormality of the corticospinal tract (HP:0002492)2.85854303
22Epistaxis (HP:0000421)2.84966176
23Axonal loss (HP:0003447)2.84004448
24Abnormality of macrophages (HP:0004311)2.83422643
25Abnormal platelet volume (HP:0011876)2.74977006
26Ankle clonus (HP:0011448)2.74216949
27Abnormality of the intervertebral disk (HP:0005108)2.74214177
28Megalencephaly (HP:0001355)2.69782525
29Hemorrhage of the eye (HP:0011885)2.66354423
30Increased mean platelet volume (HP:0011877)2.59813278
31Abnormal hemoglobin (HP:0011902)2.59028714
32Diaphragmatic weakness (HP:0009113)2.58552263
33Flat acetabular roof (HP:0003180)2.53020030
34Abnormality of the gallbladder (HP:0005264)2.52449340
35Neurofibrillary tangles (HP:0002185)2.46912002
36Curly hair (HP:0002212)2.45727890
37Sleep apnea (HP:0010535)2.45556792
38Impaired platelet aggregation (HP:0003540)2.45420185
39Abnormal platelet function (HP:0011869)2.45420185
40Submucous cleft hard palate (HP:0000176)2.44515363
41Abnormality of the common coagulation pathway (HP:0010990)2.44451446
42Paralysis (HP:0003470)2.42820351
43Myocardial infarction (HP:0001658)2.41138843
44Slow saccadic eye movements (HP:0000514)2.40690855
45Vertebral compression fractures (HP:0002953)2.40233183
46Abnormal gallbladder physiology (HP:0012438)2.39810973
47Cholecystitis (HP:0001082)2.39810973
48Lower limb amyotrophy (HP:0007210)2.37570093
49Gastrointestinal infarctions (HP:0005244)2.37302980
50Febrile seizures (HP:0002373)2.37132288
51Turricephaly (HP:0000262)2.29070016
52Failure to thrive in infancy (HP:0001531)2.26726533
53Joint hemorrhage (HP:0005261)2.26573134
54Cerebral inclusion bodies (HP:0100314)2.23599895
55Hypochromic microcytic anemia (HP:0004840)2.23595716
56Recurrent abscess formation (HP:0002722)2.22106427
57Long palpebral fissure (HP:0000637)2.21972200
58Increased circulating renin level (HP:0000848)2.21609936
59Increased serum ferritin (HP:0003281)2.20130428
60Hypokalemic alkalosis (HP:0001949)2.19042438
61Increased connective tissue (HP:0009025)2.18293015
62Osteolytic defects of the hand bones (HP:0009699)2.18279336
63Osteolytic defects of the phalanges of the hand (HP:0009771)2.18279336
64Toxemia of pregnancy (HP:0100603)2.18003496
65Foot dorsiflexor weakness (HP:0009027)2.15873918
66Amyloidosis (HP:0011034)2.15473925
67Limb dystonia (HP:0002451)2.15012822
68Recurrent bacterial skin infections (HP:0005406)2.14996944
69Hypomagnesemia (HP:0002917)2.14520212
70Petechiae (HP:0000967)2.14137240
71Orthostatic hypotension (HP:0001278)2.13065712
72Abnormality of magnesium homeostasis (HP:0004921)2.11273858
73Hypochromic anemia (HP:0001931)2.09551361
74Decreased motor nerve conduction velocity (HP:0003431)2.09294722
75Myokymia (HP:0002411)2.09284972
76Onion bulb formation (HP:0003383)2.08688665
77Hypertriglyceridemia (HP:0002155)2.07647285
78Arterial tortuosity (HP:0005116)2.06955020
79Orchitis (HP:0100796)2.05963795
80Hypercortisolism (HP:0001578)2.05409681
81Abnormality of iron homeostasis (HP:0011031)2.04807560
82Myositis (HP:0100614)2.02702582
83Anosmia (HP:0000458)2.02194918
84Cellulitis (HP:0100658)2.01919211
85Nasal polyposis (HP:0100582)2.01816802
86Segmental peripheral demyelination/remyelination (HP:0003481)2.00081857
87Abnormality of hair growth rate (HP:0011363)1.99246266
88Slow-growing hair (HP:0002217)1.99246266
89Diplopia (HP:0000651)1.98397409
90Abnormality of binocular vision (HP:0011514)1.98397409
91Thickened helices (HP:0000391)1.97782113
92Abnormality of the Achilles tendon (HP:0005109)1.96992738
93Recurrent gram-negative bacterial infections (HP:0005420)1.96819772
94Lower limb muscle weakness (HP:0007340)1.96579950
95Distal upper limb amyotrophy (HP:0007149)1.96094359
96Upper limb amyotrophy (HP:0009129)1.96094359
97Protrusio acetabuli (HP:0003179)1.95731729
98Peritonitis (HP:0002586)1.95385384
99Persistence of primary teeth (HP:0006335)1.95185684
100Tetany (HP:0001281)1.95043001
101Metabolic alkalosis (HP:0200114)1.94430495
102Gingivitis (HP:0000230)1.93824579
103Distal lower limb muscle weakness (HP:0009053)1.91287111
104Xanthomatosis (HP:0000991)1.91027703
105Urticaria (HP:0001025)1.89961863
106Progressive sensorineural hearing impairment (HP:0000408)1.89455078
107Broad face (HP:0000283)1.89342475
108Hemiparesis (HP:0001269)1.88708193
109Truncal ataxia (HP:0002078)1.87404499
110Subacute progressive viral hepatitis (HP:0006572)1.86890851
111Xerostomia (HP:0000217)1.86801881
112Broad nasal tip (HP:0000455)1.85196328
113Cerebral hypomyelination (HP:0006808)1.84669253
114Adrenal hypoplasia (HP:0000835)1.84441155
115Abnormality of the anterior horn cell (HP:0006802)1.84168077
116Degeneration of anterior horn cells (HP:0002398)1.84168077
117Dysostosis multiplex (HP:0000943)1.83648955
118Vascular tortuosity (HP:0004948)1.83230236
119Cerebral aneurysm (HP:0004944)1.82956095
120Interstitial pulmonary disease (HP:0006530)1.81929640
121Systemic lupus erythematosus (HP:0002725)1.81259484
122Peripheral hypomyelination (HP:0007182)1.80779321
123Abnormality of the nasal mucosa (HP:0000433)1.80723123
124Achilles tendon contracture (HP:0001771)1.80643432
125Abnormality of carpal bone ossification (HP:0006257)1.80548900
126Abnormality of the foot musculature (HP:0001436)1.80235293
127Polydipsia (HP:0001959)1.79962641
128Abnormal drinking behavior (HP:0030082)1.79962641
129Spastic paraplegia (HP:0001258)1.79034284
130Obstructive sleep apnea (HP:0002870)1.78563865
131Abnormality of complement system (HP:0005339)1.78532274
132Short nail (HP:0001799)1.78153897
133Bruising susceptibility (HP:0000978)1.78030326
134Bilateral sensorineural hearing impairment (HP:0008619)1.77540716
135Ileus (HP:0002595)1.77129554
136Distal sensory impairment (HP:0002936)1.73783891
137Abnormality of glycosphingolipid metabolism (HP:0004343)1.70782981
138Abnormality of glycolipid metabolism (HP:0010969)1.70782981
139Abnormality of liposaccharide metabolism (HP:0010968)1.70782981
140Polyuria (HP:0000103)1.69879516
141Focal segmental glomerulosclerosis (HP:0000097)1.69411892
142Renal salt wasting (HP:0000127)1.68924038
143Increased cerebral lipofuscin (HP:0011813)1.68498391
144Fatigue (HP:0012378)1.68488963
145Hyperactive renin-angiotensin system (HP:0000841)1.67964601
146Hepatocellular carcinoma (HP:0001402)1.66914346
147Adrenal overactivity (HP:0002717)1.66269322
148Abnormality of the aortic arch (HP:0012303)1.65760935
149Pustule (HP:0200039)1.65440288
150Abnormality of renal excretion (HP:0011036)1.65308375
151Hypoplasia of the iris (HP:0007676)1.65103382
152Distal lower limb amyotrophy (HP:0008944)1.64873690
153Polycythemia (HP:0001901)1.64659527
154Paraplegia (HP:0010550)1.64109033
155Heterotopia (HP:0002282)1.63921963
156Mitral stenosis (HP:0001718)1.63560598
157Ankyloglossia (HP:0010296)1.63473252
158Stridor (HP:0010307)1.63181090
159Spontaneous hematomas (HP:0007420)1.63134721
160Arterial thrombosis (HP:0004420)1.63043046
161Glomerulosclerosis (HP:0000096)1.62990086
162Obstructive lung disease (HP:0006536)1.62859979
163Chronic obstructive pulmonary disease (HP:0006510)1.62859979
164Hyperparathyroidism (HP:0000843)1.62821002
165Gastrointestinal inflammation (HP:0004386)1.62517361
166Abnormal ossification of hand bones (HP:0005921)1.62220504
167Episodic fever (HP:0001954)1.61697242
168Spina bifida occulta (HP:0003298)1.61221065
169Acanthocytosis (HP:0001927)1.61057671
170Asymmetry of the thorax (HP:0001555)1.60498295
171Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.60389088
172Hand muscle atrophy (HP:0009130)1.60092948
173Abnormality of the gastric mucosa (HP:0004295)1.60082198
174Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.60041270

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B5.75685104
2ARAF4.17941798
3PIM24.09714865
4ERN13.09201850
5IRAK32.67401921
6ICK2.66512180
7MAP3K32.49092115
8BMPR22.43027579
9ERBB32.42846409
10BRAF2.38611934
11WNK42.22277207
12LIMK12.08912114
13RIPK42.06405538
14FGFR41.99079833
15PRKD31.97986436
16SIK11.96716167
17SMG11.96708892
18SGK4941.95664362
19SGK2231.95664362
20TESK11.93769818
21RIPK11.87679042
22STK391.83597568
23MST1R1.80709201
24DYRK21.71204251
25EPHB11.70179828
26GRK61.61031566
27CDK121.60196067
28TAOK21.59531545
29TAOK11.55477190
30MAP3K141.51786252
31MAP3K111.45172369
32MARK11.43225187
33UHMK11.41983304
34OXSR11.41352645
35ZAP701.35490854
36DYRK1B1.33692262
37BMX1.26572847
38PAK41.25434660
39LMTK21.22854246
40SGK21.22469456
41SGK31.19212965
42KSR21.14983171
43YES11.14689703
44CHUK1.14193388
45IRAK41.13869343
46DAPK21.11285545
47CSK1.10175693
48WNK11.07572906
49PDGFRA1.07223069
50MAP4K11.05073419
51RPS6KA21.04170120
52PKN21.02644091
53EPHA21.02274872
54NME21.01902389
55STK381.00230537
56NTRK20.96943948
57FGFR30.96592682
58AKT30.95560281
59FGR0.94524534
60SIK30.93586175
61TYK20.93578563
62TGFBR20.92705927
63MAP3K20.92557143
64PKN10.92196474
65TTN0.90991052
66PDPK10.88627050
67TRPM70.87081147
68PLK20.85878977
69BLK0.85364989
70PIM10.85129662
71MAPK130.84485013
72TYRO30.83126103
73EIF2AK10.83061054
74EIF2AK20.81546590
75RAF10.80906682
76PTK60.80070135
77TESK20.78505558
78MET0.77803349
79MAP3K80.76159179
80JAK30.74895985
81BCR0.74628875
82MARK20.74192832
83DAPK30.73363246
84PRKD20.72023945
85ROCK20.71521525
86TRIB30.69905208
87MAP3K60.69842495
88MAP3K50.69068536
89EPHB20.68977354
90MAP3K100.68757820
91GRK50.67972715
92IKBKB0.67250613
93CLK10.65218473
94MAPKAPK50.65108091
95LRRK20.63452096
96RET0.63039834
97EEF2K0.62625807
98DDR20.62323317
99ROCK10.62069027
100HCK0.61741963
101CDK50.61287506
102PAK60.60682769
103MTOR0.60553138
104SIK20.60340810
105RPS6KC10.59827297
106RPS6KL10.59827297
107PDK10.59694562
108STK100.59643550
109IRAK20.59144597
110MAPK110.58381979
111MAP3K130.56116033
112BTK0.55676462
113RPS6KA60.54567142
114TNK20.54101987
115PAK10.53618397
116MINK10.53270103
117PTK2B0.53177398
118TIE10.51928896
119IKBKE0.51277911
120STK40.50688101
121JAK10.50142177
122PRKCH0.49872719
123KSR10.49754962
124RPS6KA10.49462026
125SYK0.49239227
126LATS20.48625718
127SCYL20.48555526
128JAK20.48491201
129CDK140.47957876
130PAK30.47871218
131PRKG20.47160389
132RPS6KA50.45876731
133CSNK1A1L0.45221462
134CDK180.44847563
135CDC42BPA0.44768056
136CDK150.44317436
137MOS0.39998635
138HIPK20.39606349
139MAP2K30.39538487
140PDGFRB0.39445313
141DMPK0.38979499
142AURKA0.38143936
143PRKD10.36742471
144* MAPKAPK20.35516444
145PRKCZ0.35018495
146NTRK10.34733775
147GRK70.34705347
148PTK20.33705899
149CDK11A0.32455675
150CSF1R0.32064606
151MARK30.31243681
152MAP3K70.30872092
153TBK10.30734415
154MAP3K10.30037639
155WNK30.29030275

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.17538785
2Collecting duct acid secretion_Homo sapiens_hsa049662.22169517
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.96689767
4Olfactory transduction_Homo sapiens_hsa047401.95715193
5Endometrial cancer_Homo sapiens_hsa052131.94193262
6Other glycan degradation_Homo sapiens_hsa005111.90633938
7Synaptic vesicle cycle_Homo sapiens_hsa047211.88743727
8Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.87880496
9Allograft rejection_Homo sapiens_hsa053301.76062979
10Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.74921065
11Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.73177985
12* Chronic myeloid leukemia_Homo sapiens_hsa052201.64633237
13Bladder cancer_Homo sapiens_hsa052191.50888358
14Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.47094027
15Non-small cell lung cancer_Homo sapiens_hsa052231.46248458
16B cell receptor signaling pathway_Homo sapiens_hsa046621.45235890
17Axon guidance_Homo sapiens_hsa043601.41675665
18Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.41269433
19Complement and coagulation cascades_Homo sapiens_hsa046101.41072528
20Endocytosis_Homo sapiens_hsa041441.38997788
21Chemokine signaling pathway_Homo sapiens_hsa040621.38519449
22Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.36011075
23ErbB signaling pathway_Homo sapiens_hsa040121.33018135
24Tight junction_Homo sapiens_hsa045301.32974174
25Glycosaminoglycan degradation_Homo sapiens_hsa005311.26656668
26Shigellosis_Homo sapiens_hsa051311.26293726
27Adipocytokine signaling pathway_Homo sapiens_hsa049201.24656588
28Rheumatoid arthritis_Homo sapiens_hsa053231.23146347
29Type I diabetes mellitus_Homo sapiens_hsa049401.21770369
30Neurotrophin signaling pathway_Homo sapiens_hsa047221.21166975
31African trypanosomiasis_Homo sapiens_hsa051431.20442324
32* Pancreatic cancer_Homo sapiens_hsa052121.20172099
33Glioma_Homo sapiens_hsa052141.18057718
34Central carbon metabolism in cancer_Homo sapiens_hsa052301.17915330
35* Apoptosis_Homo sapiens_hsa042101.15280374
36Hepatitis C_Homo sapiens_hsa051601.15092907
37Renal cell carcinoma_Homo sapiens_hsa052111.14282300
38Phagosome_Homo sapiens_hsa041451.13785882
39Graft-versus-host disease_Homo sapiens_hsa053321.13391676
40Vitamin B6 metabolism_Homo sapiens_hsa007501.13008980
41Prion diseases_Homo sapiens_hsa050201.12966759
42Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.10889609
43Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.10844413
44Acute myeloid leukemia_Homo sapiens_hsa052211.09766763
45Platelet activation_Homo sapiens_hsa046111.09501779
46Colorectal cancer_Homo sapiens_hsa052101.07167768
47Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.07013182
48Fructose and mannose metabolism_Homo sapiens_hsa000511.06970416
49Salmonella infection_Homo sapiens_hsa051321.05033130
50Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.03536272
51GABAergic synapse_Homo sapiens_hsa047271.03200390
52Cholinergic synapse_Homo sapiens_hsa047251.02288744
53Autoimmune thyroid disease_Homo sapiens_hsa053201.02006283
54mTOR signaling pathway_Homo sapiens_hsa041501.00123184
55Prostate cancer_Homo sapiens_hsa052150.98747540
56VEGF signaling pathway_Homo sapiens_hsa043700.96990857
57Melanoma_Homo sapiens_hsa052180.96867477
58Toll-like receptor signaling pathway_Homo sapiens_hsa046200.94550136
59Regulation of actin cytoskeleton_Homo sapiens_hsa048100.94301915
60Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.94003836
61Pentose phosphate pathway_Homo sapiens_hsa000300.93847681
62MicroRNAs in cancer_Homo sapiens_hsa052060.93767116
63Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.92739269
64Prolactin signaling pathway_Homo sapiens_hsa049170.92390276
65* Ras signaling pathway_Homo sapiens_hsa040140.91989498
66Insulin signaling pathway_Homo sapiens_hsa049100.91389436
67Serotonergic synapse_Homo sapiens_hsa047260.90226009
68Pertussis_Homo sapiens_hsa051330.90087513
69Galactose metabolism_Homo sapiens_hsa000520.89801680
70Leukocyte transendothelial migration_Homo sapiens_hsa046700.89587507
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.89104009
72RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.88621513
73TNF signaling pathway_Homo sapiens_hsa046680.88078764
74Notch signaling pathway_Homo sapiens_hsa043300.87500180
75Insulin resistance_Homo sapiens_hsa049310.87132853
76Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.86201880
77HIF-1 signaling pathway_Homo sapiens_hsa040660.85869740
78Staphylococcus aureus infection_Homo sapiens_hsa051500.85750886
79Morphine addiction_Homo sapiens_hsa050320.85581154
80* Toxoplasmosis_Homo sapiens_hsa051450.84732595
81Hippo signaling pathway_Homo sapiens_hsa043900.84398767
82Tuberculosis_Homo sapiens_hsa051520.84226988
83Dopaminergic synapse_Homo sapiens_hsa047280.83450381
84Lysosome_Homo sapiens_hsa041420.83228906
85Thyroid cancer_Homo sapiens_hsa052160.83063694
86Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.82944545
87Viral myocarditis_Homo sapiens_hsa054160.82900352
88Alcoholism_Homo sapiens_hsa050340.82333650
89Viral carcinogenesis_Homo sapiens_hsa052030.82288367
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.81909134
91Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.81583103
92AMPK signaling pathway_Homo sapiens_hsa041520.81147814
93Hematopoietic cell lineage_Homo sapiens_hsa046400.80960873
94Inositol phosphate metabolism_Homo sapiens_hsa005620.80797246
95Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.79965991
96Adherens junction_Homo sapiens_hsa045200.79810418
97Ether lipid metabolism_Homo sapiens_hsa005650.79733541
98* Jak-STAT signaling pathway_Homo sapiens_hsa046300.77969328
99Malaria_Homo sapiens_hsa051440.76296199
100Leishmaniasis_Homo sapiens_hsa051400.74749526
101Gap junction_Homo sapiens_hsa045400.74409322
102Hepatitis B_Homo sapiens_hsa051610.74344155
103T cell receptor signaling pathway_Homo sapiens_hsa046600.74130134
104Choline metabolism in cancer_Homo sapiens_hsa052310.72292522
105Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.71444907
106Glutamatergic synapse_Homo sapiens_hsa047240.71301167
107MAPK signaling pathway_Homo sapiens_hsa040100.71078386
108FoxO signaling pathway_Homo sapiens_hsa040680.70554342
109Influenza A_Homo sapiens_hsa051640.70417372
110Measles_Homo sapiens_hsa051620.69619766
111Herpes simplex infection_Homo sapiens_hsa051680.69326382
112Rap1 signaling pathway_Homo sapiens_hsa040150.69208324
113* Small cell lung cancer_Homo sapiens_hsa052220.69124959
114Phospholipase D signaling pathway_Homo sapiens_hsa040720.68249607
115GnRH signaling pathway_Homo sapiens_hsa049120.68126208
116Circadian entrainment_Homo sapiens_hsa047130.66197854
117Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66003579
118* Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65570458
119* NF-kappa B signaling pathway_Homo sapiens_hsa040640.65274563
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.64251844
121Legionellosis_Homo sapiens_hsa051340.63106361
122Osteoclast differentiation_Homo sapiens_hsa043800.62754434
123Proteoglycans in cancer_Homo sapiens_hsa052050.62152338
124AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.61158676
125Phosphatidylinositol signaling system_Homo sapiens_hsa040700.60986979
126Steroid biosynthesis_Homo sapiens_hsa001000.60580960
127N-Glycan biosynthesis_Homo sapiens_hsa005100.59645001
128Vibrio cholerae infection_Homo sapiens_hsa051100.59295904
129Amoebiasis_Homo sapiens_hsa051460.59124643
130Focal adhesion_Homo sapiens_hsa045100.58852834
131Asthma_Homo sapiens_hsa053100.58310895
132NOD-like receptor signaling pathway_Homo sapiens_hsa046210.58017352
133Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57138021
134* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.56270496
135Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56034657
136Fatty acid biosynthesis_Homo sapiens_hsa000610.54759533
137ECM-receptor interaction_Homo sapiens_hsa045120.51367153
138Glycerophospholipid metabolism_Homo sapiens_hsa005640.50894641

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