BCL2A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and is up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of interleukin-12 production (GO:0032695)4.93922786
2response to peptidoglycan (GO:0032494)4.84769177
3regulation of vitamin D biosynthetic process (GO:0060556)4.79878980
4positive regulation of gamma-delta T cell activation (GO:0046645)4.44716471
5regulation of chronic inflammatory response (GO:0002676)4.36693511
6lipopolysaccharide-mediated signaling pathway (GO:0031663)4.06202468
7positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.05645740
8defense response to protozoan (GO:0042832)4.03962652
9positive regulation of chemokine biosynthetic process (GO:0045080)3.99870426
10regulation of podosome assembly (GO:0071801)3.98556112
11neutrophil activation involved in immune response (GO:0002283)3.90713795
12macrophage activation involved in immune response (GO:0002281)3.88707846
13regulation of T-helper 1 cell differentiation (GO:0045625)3.88479414
14response to protozoan (GO:0001562)3.87561982
15immunoglobulin mediated immune response (GO:0016064)3.85775751
16positive regulation of interleukin-17 production (GO:0032740)3.81634581
17modulation by symbiont of host immune response (GO:0052553)3.78371098
18positive regulation by symbiont of host defense response (GO:0052509)3.78371098
19modulation by symbiont of host defense response (GO:0052031)3.78371098
20modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.78371098
21modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.78371098
22positive regulation by organism of defense response of other organism involved in symbiotic interact3.78371098
23regulation of vitamin metabolic process (GO:0030656)3.75196341
24NIK/NF-kappaB signaling (GO:0038061)3.72057431
25negative regulation of cell killing (GO:0031342)3.71717301
26negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.71717301
27detection of molecule of bacterial origin (GO:0032490)3.70693210
28myeloid dendritic cell differentiation (GO:0043011)3.67849793
29positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.65765677
30regulation of interferon-alpha production (GO:0032647)3.64942005
31type I interferon signaling pathway (GO:0060337)3.63244983
32cellular response to type I interferon (GO:0071357)3.63244983
33positive regulation of interleukin-10 production (GO:0032733)3.61215586
34response to type I interferon (GO:0034340)3.57883816
35T-helper 1 type immune response (GO:0042088)3.56959573
36regulation of chemokine biosynthetic process (GO:0045073)3.54497276
37interferon-gamma-mediated signaling pathway (GO:0060333)3.52533646
38regulation of gamma-delta T cell activation (GO:0046643)3.48866867
39germinal center formation (GO:0002467)3.44262768
40regulation of immunoglobulin secretion (GO:0051023)3.43718262
41cellular extravasation (GO:0045123)3.41939263
42positive regulation of NF-kappaB import into nucleus (GO:0042346)3.40335926
43positive regulation of type 2 immune response (GO:0002830)3.38476782
44regulation of interferon-beta biosynthetic process (GO:0045357)3.34858693
45positive regulation of isotype switching (GO:0045830)3.34688416
46myeloid dendritic cell activation (GO:0001773)3.32618548
47positive regulation of heat generation (GO:0031652)3.29495912
48regulation of interleukin-12 production (GO:0032655)3.28726080
49regulation of dendritic cell antigen processing and presentation (GO:0002604)3.28266413
50positive regulation of interferon-alpha production (GO:0032727)3.28243562
51regulation of T-helper cell differentiation (GO:0045622)3.27611996
52regulation of fever generation (GO:0031620)3.24478610
53positive regulation of B cell mediated immunity (GO:0002714)3.24100966
54positive regulation of immunoglobulin mediated immune response (GO:0002891)3.24100966
55antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.20732427
56CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.20395440
57regulation of interleukin-17 production (GO:0032660)3.19621496
58regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.19395927
59negative regulation of cytokine production involved in immune response (GO:0002719)3.18189081
60positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.17340554
61detection of other organism (GO:0098543)3.16698040
62leukocyte aggregation (GO:0070486)3.15450114
63B cell mediated immunity (GO:0019724)3.14055817
64granulocyte activation (GO:0036230)3.13623952
65positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.13343110
66negative regulation of T cell mediated immunity (GO:0002710)3.11611860
67positive regulation of natural killer cell differentiation (GO:0032825)3.11493939
68dendritic cell differentiation (GO:0097028)3.10407863
69response to muramyl dipeptide (GO:0032495)3.07903663
70positive regulation of B cell proliferation (GO:0030890)3.06984287
71regulation of T-helper 2 cell differentiation (GO:0045628)3.06529191
72regulation of isotype switching to IgG isotypes (GO:0048302)3.06494174
73detection of external biotic stimulus (GO:0098581)3.04286286
74regulation of cytokine secretion involved in immune response (GO:0002739)3.03657531
75positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.03158196
76negative regulation of nitric oxide biosynthetic process (GO:0045019)3.02197553
77positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.01131457
78T-helper cell differentiation (GO:0042093)3.00139486
79CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.00139486
80regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.99952436
81positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.96282832
82regulation of T cell tolerance induction (GO:0002664)2.96218166
83macrophage activation (GO:0042116)2.95812708
84positive regulation of interleukin-12 production (GO:0032735)2.95692324
85regulation of interleukin-10 production (GO:0032653)2.95642186
86positive regulation of antigen processing and presentation (GO:0002579)2.95142310
87regulation of interleukin-2 biosynthetic process (GO:0045076)2.93525022
88regulation of interleukin-8 biosynthetic process (GO:0045414)2.92312767
89positive regulation of acute inflammatory response (GO:0002675)2.92288722
90regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.92205077
91positive regulation of DNA recombination (GO:0045911)2.91267320
92detection of biotic stimulus (GO:0009595)2.90567089
93T cell migration (GO:0072678)2.90523735
94neutrophil activation (GO:0042119)2.90345858
95regulation of interleukin-12 biosynthetic process (GO:0045075)2.89974380
96myeloid cell activation involved in immune response (GO:0002275)2.89377814
97regulation of NF-kappaB import into nucleus (GO:0042345)2.89321220
98regulation of antigen processing and presentation (GO:0002577)2.89281329
99positive regulation of cytokine biosynthetic process (GO:0042108)2.87923602
100regulation of regulatory T cell differentiation (GO:0045589)2.85536722

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.44566273
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.45888835
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.08030254
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.00535021
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.93648180
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.87674091
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.87535831
8IRF8_27001747_Chip-Seq_BMDM_Mouse3.86061138
9* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.65760483
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.55746626
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.30122527
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.21766057
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.16843850
14STAT4_19710469_ChIP-ChIP_TH1__Mouse3.16480866
15MYB_21317192_ChIP-Seq_ERMYB_Mouse3.00742663
16NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.99304247
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.68597651
18Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.67541420
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.59728589
20* SPI1_23547873_ChIP-Seq_NB4_Human2.37516159
21RUNX_20019798_ChIP-Seq_JUKART_Human2.24480657
22VDR_24787735_ChIP-Seq_THP-1_Human2.22120163
23VDR_24763502_ChIP-Seq_THP-1_Human2.18323324
24GATA1_22025678_ChIP-Seq_K562_Human2.16349259
25* MYB_26560356_Chip-Seq_TH2_Human2.09609155
26BRD4_27068464_Chip-Seq_AML-cells_Mouse2.07915502
27RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.98457427
28SMAD_19615063_ChIP-ChIP_OVARY_Human1.97246132
29SPI1_23127762_ChIP-Seq_K562_Human1.92031975
30VDR_21846776_ChIP-Seq_THP-1_Human1.85421374
31* MAF_26560356_Chip-Seq_TH1_Human1.84462672
32CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.81812064
33PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.81332938
34SCL_19346495_ChIP-Seq_HPC-7_Human1.79266653
35NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.76595948
36E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.73340790
37RUNX1_22412390_ChIP-Seq_EML_Mouse1.69139096
38CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.66733682
39FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.62267889
40* MYB_26560356_Chip-Seq_TH1_Human1.58761791
41MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.55574980
42VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.49981675
43PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.47297782
44GATA3_26560356_Chip-Seq_TH2_Human1.47163370
45PU_27001747_Chip-Seq_BMDM_Mouse1.45138471
46LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.44835563
47CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.44048496
48SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.43511453
49CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.43388708
50LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.42774424
51GATA3_27048872_Chip-Seq_THYMUS_Human1.42459896
52FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.39915032
53UTX_26944678_Chip-Seq_JUKART_Human1.37807706
54NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.37013372
55SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.30925809
56CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.30590303
57MYC_22102868_ChIP-Seq_BL_Human1.29250989
58STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.28516346
59STAT6_21828071_ChIP-Seq_BEAS2B_Human1.27116845
60MAF_26560356_Chip-Seq_TH2_Human1.26031026
61PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.26029935
62PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21027683
63STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.20939154
64GATA2_22383799_ChIP-Seq_G1ME_Mouse1.17255788
65NOTCH1_21737748_ChIP-Seq_TLL_Human1.16896553
66KDM2B_26808549_Chip-Seq_SUP-B15_Human1.16666161
67TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.16486252
68GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.16388325
69TCF7_22412390_ChIP-Seq_EML_Mouse1.12414347
70GATA1_19941827_ChIP-Seq_MEL_Mouse1.08471547
71TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01637607
72SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.95558959
73GATA2_21666600_ChIP-Seq_HMVEC_Human0.95496735
74VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.94479346
75PU.1_20513432_ChIP-Seq_Bcells_Mouse0.92899607
76KDM2B_26808549_Chip-Seq_DND41_Human0.92291667
77GATA1_22383799_ChIP-Seq_G1ME_Mouse0.92076152
78SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.91997016
79STAT1_20625510_ChIP-Seq_HELA_Human0.91921246
80GATA1_19941826_ChIP-Seq_K562_Human0.86210719
81EGR1_19032775_ChIP-ChIP_M12_Human0.86176212
82ELK3_25401928_ChIP-Seq_HUVEC_Human0.84492787
83TFEB_21752829_ChIP-Seq_HELA_Human0.83164540
84SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82453049
85KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.80726789
86KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.79885397
87ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.77083926
88* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76339085
89TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.74366458
90GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74298920
91BCL6_27268052_Chip-Seq_Bcells_Human0.72052913
92IKZF1_21737484_ChIP-ChIP_HCT116_Human0.71953062
93FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.71255061
94CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.71166897
95CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.70474931
96SMRT_27268052_Chip-Seq_Bcells_Human0.70369865
97KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.69009756
98KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.69009756
99KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.69009756
100CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.67101694

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation5.01117031
2MP0001835_abnormal_antigen_presentation4.11886045
3MP0003724_increased_susceptibility_to4.05419327
4MP0006082_CNS_inflammation3.60352832
5MP0003436_decreased_susceptibility_to3.58753961
6MP0002148_abnormal_hypersensitivity_rea3.48315500
7MP0009785_altered_susceptibility_to3.41802897
8MP0005671_abnormal_response_to3.16630913
9MP0005000_abnormal_immune_tolerance3.10847830
10MP0001790_abnormal_immune_system3.01671686
11MP0005387_immune_system_phenotype3.01671686
12MP0002419_abnormal_innate_immunity2.78893758
13MP0005025_abnormal_response_to2.73423837
14MP0001800_abnormal_humoral_immune2.67010678
15MP0003300_gastrointestinal_ulcer2.65308850
16MP0002723_abnormal_immune_serum2.50742730
17MP0002452_abnormal_antigen_presenting2.49801941
18MP0000685_abnormal_immune_system2.48959685
19MP0004510_myositis2.40364922
20MP0009764_decreased_sensitivity_to2.29956470
21MP0002420_abnormal_adaptive_immunity2.14355815
22MP0001819_abnormal_immune_cell2.12916687
23MP0001853_heart_inflammation2.09091578
24MP0005058_abnormal_lysosome_morphology2.08429962
25MP0001533_abnormal_skeleton_physiology1.98282970
26MP0010155_abnormal_intestine_physiology1.96440953
27MP0004947_skin_inflammation1.96026325
28MP0001845_abnormal_inflammatory_respons1.93557380
29MP0003075_altered_response_to1.87561550
30MP0002405_respiratory_system_inflammati1.85736713
31MP0009840_abnormal_foam_cell1.79486075
32MP0009278_abnormal_bone_marrow1.78465771
33MP0005310_abnormal_salivary_gland1.75196722
34MP0009333_abnormal_splenocyte_physiolog1.73097562
35MP0005451_abnormal_body_composition1.69838494
36MP0008469_abnormal_protein_level1.65791261
37MP0003172_abnormal_lysosome_physiology1.63263863
38MP0008004_abnormal_stomach_pH1.62568386
39MP0000604_amyloidosis1.59751737
40MP0000343_altered_response_to1.56902282
41MP0000716_abnormal_immune_system1.55898320
42MP0005167_abnormal_blood-brain_barrier1.52936548
43MP0003763_abnormal_thymus_physiology1.47020489
44MP0005464_abnormal_platelet_physiology1.44209329
45MP0002398_abnormal_bone_marrow1.43638215
46MP0005166_decreased_susceptibility_to1.43020806
47MP0002139_abnormal_hepatobiliary_system1.41738645
48MP0003806_abnormal_nucleotide_metabolis1.40487035
49MP0003448_altered_tumor_morphology1.40438463
50MP0005397_hematopoietic_system_phenotyp1.35405115
51MP0001545_abnormal_hematopoietic_system1.35405115
52MP0002998_abnormal_bone_remodeling1.34492251
53MP0003191_abnormal_cellular_cholesterol1.32583345
54MP0001873_stomach_inflammation1.32393815
55MP0000858_altered_metastatic_potential1.28994946
56MP0002254_reproductive_system_inflammat1.28812730
57MP0002332_abnormal_exercise_endurance1.24431398
58MP0002138_abnormal_hepatobiliary_system1.21709023
59MP0002429_abnormal_blood_cell1.20293088
60MP0000689_abnormal_spleen_morphology1.19673552
61MP0003690_abnormal_glial_cell1.15827838
62MP0003656_abnormal_erythrocyte_physiolo1.14320192
63MP0002722_abnormal_immune_system1.12347977
64MP0003453_abnormal_keratinocyte_physiol1.07851041
65MP0000465_gastrointestinal_hemorrhage1.07811111
66MP0005164_abnormal_response_to1.01009157
67MP0009763_increased_sensitivity_to0.98486746
68MP0001663_abnormal_digestive_system0.92188767
69MP0009765_abnormal_xenobiotic_induced0.87728466
70MP0002277_abnormal_respiratory_mucosa0.86980339
71MP0002006_tumorigenesis0.83589019
72MP0003195_calcinosis0.83094949
73MP0006054_spinal_hemorrhage0.82877603
74MP0005390_skeleton_phenotype0.79893566
75MP0004883_abnormal_blood_vessel0.78357960
76MP0003828_pulmonary_edema0.75468142
77MP0003866_abnormal_defecation0.75065443
78MP0008260_abnormal_autophagy0.72122230
79MP0001348_abnormal_lacrimal_gland0.71217424
80MP0000920_abnormal_myelination0.71092091
81MP0005165_increased_susceptibility_to0.70709551
82MP0004808_abnormal_hematopoietic_stem0.69323762
83MP0000703_abnormal_thymus_morphology0.68901209
84MP0000249_abnormal_blood_vessel0.67844744
85MP0001851_eye_inflammation0.66349675
86MP0003045_fibrosis0.65942834
87MP0002166_altered_tumor_susceptibility0.62794040
88MP0003091_abnormal_cell_migration0.61871361
89MP0003183_abnormal_peptide_metabolism0.61427968
90MP0003795_abnormal_bone_structure0.59878066
91MP0008874_decreased_physiological_sensi0.59849099
92MP0003646_muscle_fatigue0.58780705
93MP0002933_joint_inflammation0.56377469
94MP0002693_abnormal_pancreas_physiology0.56148378
95MP0000609_abnormal_liver_physiology0.55088020
96MP0001542_abnormal_bone_strength0.54793264
97MP0002877_abnormal_melanocyte_morpholog0.52770104
98MP0005535_abnormal_body_temperature0.52312391
99MP0000371_diluted_coat_color0.51992764
100MP0005319_abnormal_enzyme/_coenzyme0.50324977

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)5.70384383
2Abnormality of liposaccharide metabolism (HP:0010968)5.52444245
3Abnormality of glycosphingolipid metabolism (HP:0004343)5.52444245
4Abnormality of glycolipid metabolism (HP:0010969)5.52444245
5Optic neuritis (HP:0100653)5.48478168
6Retrobulbar optic neuritis (HP:0100654)5.48478168
7Orchitis (HP:0100796)5.28355830
8Abnormality of macrophages (HP:0004311)5.12186570
9Recurrent bacterial skin infections (HP:0005406)5.08574371
10Myositis (HP:0100614)4.91746593
11Eczematoid dermatitis (HP:0000976)4.66088215
12Recurrent abscess formation (HP:0002722)4.63691661
13Mediastinal lymphadenopathy (HP:0100721)4.36999190
14Elevated erythrocyte sedimentation rate (HP:0003565)4.25725508
15Keratoconjunctivitis sicca (HP:0001097)3.95497501
16Autoimmune thrombocytopenia (HP:0001973)3.87608660
17Recurrent gram-negative bacterial infections (HP:0005420)3.63803064
18Increased cerebral lipofuscin (HP:0011813)3.63216576
19Keratoconjunctivitis (HP:0001096)3.61689598
20Pulmonary infiltrates (HP:0002113)3.61431096
21Increased IgM level (HP:0003496)3.59214714
22Vasculitis (HP:0002633)3.56613438
23Loss of speech (HP:0002371)3.55466727
24Vacuolated lymphocytes (HP:0001922)3.41898262
25Systemic lupus erythematosus (HP:0002725)3.38095191
26Disinhibition (HP:0000734)3.33585085
27Recurrent fungal infections (HP:0002841)3.32233723
28T lymphocytopenia (HP:0005403)3.30052521
29Abnormality of T cell number (HP:0011839)3.21534665
30Recurrent skin infections (HP:0001581)3.16247591
31Obstructive lung disease (HP:0006536)3.12355824
32Chronic obstructive pulmonary disease (HP:0006510)3.12355824
33Hemoptysis (HP:0002105)3.12213852
34Gangrene (HP:0100758)3.11722836
35Meningitis (HP:0001287)3.07013283
36Dysostosis multiplex (HP:0000943)2.99078207
37Recurrent viral infections (HP:0004429)2.97067683
38Gastrointestinal infarctions (HP:0005244)2.93041844
39Encephalitis (HP:0002383)2.92637881
40Increased neuronal autofluorescent lipopigment (HP:0002074)2.92474671
41Arterial thrombosis (HP:0004420)2.82474500
42Autoimmune hemolytic anemia (HP:0001890)2.82013697
43Amyloidosis (HP:0011034)2.79852659
44Urticaria (HP:0001025)2.76774460
45Mutism (HP:0002300)2.74974104
46Anorexia (HP:0002039)2.70499613
47Leukocytosis (HP:0001974)2.68625507
48Abnormal delayed hypersensitivity skin test (HP:0002963)2.61552098
49Increased serum ferritin (HP:0003281)2.59393760
50Polyneuropathy (HP:0001271)2.58133295
51Recurrent cutaneous fungal infections (HP:0011370)2.55238395
52Chronic mucocutaneous candidiasis (HP:0002728)2.55238395
53Gingivitis (HP:0000230)2.51063815
54Myocardial infarction (HP:0001658)2.48627452
55Hypergammaglobulinemia (HP:0010702)2.47004215
56Abnormality of the pleura (HP:0002103)2.44919659
57Increased IgE level (HP:0003212)2.44511704
58Chronic diarrhea (HP:0002028)2.43635827
59Purpura (HP:0000979)2.40991833
60Abnormality of T cells (HP:0002843)2.35413027
61Petechiae (HP:0000967)2.30910566
62Abnormality of B cell number (HP:0010975)2.30337937
63Joint swelling (HP:0001386)2.29702141
64B lymphocytopenia (HP:0010976)2.29567024
65Pulmonary embolism (HP:0002204)2.26933604
66Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.25407707
67Abnormality of mucopolysaccharide metabolism (HP:0011020)2.22776111
68Abnormality of polysaccharide metabolism (HP:0011012)2.22776111
69Abnormality of glycosaminoglycan metabolism (HP:0004371)2.22776111
70Hepatosplenomegaly (HP:0001433)2.21768091
71Gastrointestinal stroma tumor (HP:0100723)2.21442837
72Interstitial pulmonary disease (HP:0006530)2.17278640
73Neurofibrillary tangles (HP:0002185)2.16823965
74Episodic fever (HP:0001954)2.16791946
75Inflammation of the large intestine (HP:0002037)2.14916535
76Vertigo (HP:0002321)2.14540556
77IgA deficiency (HP:0002720)2.11932102
78Abnormality of iron homeostasis (HP:0011031)2.11912271
79Chest pain (HP:0100749)2.09797128
80Arthralgia (HP:0002829)2.09023326
81Restrictive lung disease (HP:0002091)2.08885926
82IgG deficiency (HP:0004315)2.08434457
83Eosinophilia (HP:0001880)2.08175285
84Glomerulopathy (HP:0100820)2.07857903
85Hematochezia (HP:0002573)2.07461233
86Abnormality of the endocardium (HP:0004306)2.06428076
87Mucopolysacchariduria (HP:0008155)2.03860666
88Urinary glycosaminoglycan excretion (HP:0003541)2.03860666
89Amaurosis fugax (HP:0100576)2.02801243
90Inappropriate behavior (HP:0000719)2.02454544
91Spontaneous hematomas (HP:0007420)2.02055905
92Apathy (HP:0000741)2.01559639
93Diminished motivation (HP:0000745)2.00658728
94Fatigue (HP:0012378)1.98918955
95Recurrent bronchitis (HP:0002837)1.98235139
96Nausea (HP:0002018)1.97599354
97Nuclear cataract (HP:0100018)1.97051004
98Granulocytopenia (HP:0001913)1.96494966
99Abnormality of the pericardium (HP:0001697)1.95793905
100Gastrointestinal inflammation (HP:0004386)1.95688049

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK34.37018028
2RIPK43.78891810
3MAP3K143.77399445
4MAP4K13.18901782
5BLK3.18195329
6IRAK42.92796450
7TXK2.72129374
8TAOK22.59525953
9TBK12.52924015
10IKBKE2.52878924
11TYK22.48133557
12CSK2.46514249
13GRK72.44180804
14NME22.43628933
15BMPR22.40753245
16IKBKB2.38907249
17MATK2.14966256
18PRPF4B2.00937174
19JAK31.97205453
20MAP2K31.96516275
21MAP3K111.89152055
22FGR1.84411436
23TAOK11.80098601
24MAP3K31.76812117
25ZAP701.74232695
26IRAK11.50004793
27JAK11.47355847
28DDR21.43805156
29SYK1.41024846
30MAP3K131.40652386
31LYN1.40444653
32CHUK1.36863057
33ERN11.35612973
34IRAK21.31427154
35BTK1.26058047
36ADRBK21.23252242
37JAK21.19006469
38MAP3K11.17507340
39MOS1.17461002
40RIPK11.13254086
41PIM21.09113750
42FES1.09058905
43HCK1.08910888
44TAOK31.05921736
45TGFBR21.03328720
46LCK0.99562245
47SIK30.91726141
48ACVR1B0.91622732
49MAP3K50.90558128
50CDC42BPA0.88919351
51KIT0.88764880
52CSF1R0.86303666
53MARK30.86202844
54ITK0.78896065
55STK100.72368658
56TEC0.71651625
57PIM10.71450925
58TNK20.71173941
59EPHA30.71166174
60EPHB10.67813257
61MAP2K60.65686228
62CLK10.62844067
63KSR20.57053568
64STK240.54629087
65NEK90.51207141
66GRK60.45595175
67TESK20.44787460
68HIPK20.44511844
69ABL20.42028597
70DAPK20.39698532
71SIK20.39198064
72PDK10.38508094
73RPS6KL10.34921136
74RPS6KC10.34921136
75PIK3CG0.32499516
76CAMKK20.31254968
77MAPK40.30523746
78EGFR0.30108853
79ALK0.29929526
80FYN0.29884671
81RPS6KA60.29327857
82FGFR40.29209324
83ABL10.29092060
84CDK60.29051237
85PAK40.28523024
86FGFR30.28040362
87DYRK30.27144717
88MAPKAPK20.27099736
89PRKCQ0.27060127
90MAPK70.25929211
91PDPK10.25620714
92PRKCD0.25471343
93MST40.25393738
94INSR0.25131468
95TYRO30.24265716
96RPS6KA10.23177362
97CDK40.21238691
98SGK30.20612340
99EIF2AK30.19622027
100PKN10.17716701

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053303.53212385
2Asthma_Homo sapiens_hsa053103.23405889
3Graft-versus-host disease_Homo sapiens_hsa053323.01695818
4Autoimmune thyroid disease_Homo sapiens_hsa053202.99135232
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.94585401
6Leishmaniasis_Homo sapiens_hsa051402.88853010
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.76222155
8Toll-like receptor signaling pathway_Homo sapiens_hsa046202.74188885
9Staphylococcus aureus infection_Homo sapiens_hsa051502.62214432
10Osteoclast differentiation_Homo sapiens_hsa043802.58512458
11* NF-kappa B signaling pathway_Homo sapiens_hsa040642.55960714
12Rheumatoid arthritis_Homo sapiens_hsa053232.55324902
13Type I diabetes mellitus_Homo sapiens_hsa049402.43391164
14NOD-like receptor signaling pathway_Homo sapiens_hsa046212.42025623
15Legionellosis_Homo sapiens_hsa051342.16965067
16TNF signaling pathway_Homo sapiens_hsa046682.09368394
17Tuberculosis_Homo sapiens_hsa051522.08763648
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.08263065
19Malaria_Homo sapiens_hsa051442.07882093
20Pertussis_Homo sapiens_hsa051331.84418042
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.80801404
22Influenza A_Homo sapiens_hsa051641.79765709
23Measles_Homo sapiens_hsa051621.78707488
24Hematopoietic cell lineage_Homo sapiens_hsa046401.77219237
25Antigen processing and presentation_Homo sapiens_hsa046121.70181885
26African trypanosomiasis_Homo sapiens_hsa051431.70096823
27Other glycan degradation_Homo sapiens_hsa005111.63911103
28Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.63283127
29Toxoplasmosis_Homo sapiens_hsa051451.62031033
30Jak-STAT signaling pathway_Homo sapiens_hsa046301.56340340
31Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.55059287
32Primary immunodeficiency_Homo sapiens_hsa053401.54320366
33Lysosome_Homo sapiens_hsa041421.52895038
34B cell receptor signaling pathway_Homo sapiens_hsa046621.52825229
35Salmonella infection_Homo sapiens_hsa051321.47406973
36Viral myocarditis_Homo sapiens_hsa054161.42695533
37Herpes simplex infection_Homo sapiens_hsa051681.37720752
38Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.30594279
39Chemokine signaling pathway_Homo sapiens_hsa040621.30258065
40T cell receptor signaling pathway_Homo sapiens_hsa046601.30196563
41Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.23785051
42Phagosome_Homo sapiens_hsa041451.21407909
43Hepatitis B_Homo sapiens_hsa051611.09835781
44Hepatitis C_Homo sapiens_hsa051601.05675488
45Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.00682685
46Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.98950723
47Shigellosis_Homo sapiens_hsa051310.95912096
48Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.95456212
49Glycosaminoglycan degradation_Homo sapiens_hsa005310.90434946
50Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.89438268
51* Apoptosis_Homo sapiens_hsa042100.88011065
52Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.87777209
53Acute myeloid leukemia_Homo sapiens_hsa052210.87688344
54Epstein-Barr virus infection_Homo sapiens_hsa051690.82176688
55AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72168808
56Prolactin signaling pathway_Homo sapiens_hsa049170.70362157
57Amoebiasis_Homo sapiens_hsa051460.69105342
58Prion diseases_Homo sapiens_hsa050200.65860282
59Adipocytokine signaling pathway_Homo sapiens_hsa049200.65598247
60Collecting duct acid secretion_Homo sapiens_hsa049660.59591078
61Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59040090
62VEGF signaling pathway_Homo sapiens_hsa043700.55879944
63Bladder cancer_Homo sapiens_hsa052190.54498723
64* Transcriptional misregulation in cancer_Homo sapiens_hsa052020.51898812
65Systemic lupus erythematosus_Homo sapiens_hsa053220.51452661
66Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50826663
67HTLV-I infection_Homo sapiens_hsa051660.47715095
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46478649
69Viral carcinogenesis_Homo sapiens_hsa052030.44496189
70Sphingolipid signaling pathway_Homo sapiens_hsa040710.43355487
71Neurotrophin signaling pathway_Homo sapiens_hsa047220.42157551
72Type II diabetes mellitus_Homo sapiens_hsa049300.39694177
73Complement and coagulation cascades_Homo sapiens_hsa046100.38015982
74Leukocyte transendothelial migration_Homo sapiens_hsa046700.35251692
75Platelet activation_Homo sapiens_hsa046110.33363407
76HIF-1 signaling pathway_Homo sapiens_hsa040660.32369415
77Pancreatic cancer_Homo sapiens_hsa052120.31500934
78Dorso-ventral axis formation_Homo sapiens_hsa043200.29013282
79Mineral absorption_Homo sapiens_hsa049780.27657759
80Sphingolipid metabolism_Homo sapiens_hsa006000.26872227
81Chronic myeloid leukemia_Homo sapiens_hsa052200.25233905
82Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.24879559
83MAPK signaling pathway_Homo sapiens_hsa040100.22495728
84FoxO signaling pathway_Homo sapiens_hsa040680.20662242
85Insulin resistance_Homo sapiens_hsa049310.18915719
86Renal cell carcinoma_Homo sapiens_hsa052110.15788827
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.15537352
88Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.13970582
89Endocytosis_Homo sapiens_hsa041440.12740342
90Non-small cell lung cancer_Homo sapiens_hsa052230.11181315
91Notch signaling pathway_Homo sapiens_hsa043300.11176412
92PPAR signaling pathway_Homo sapiens_hsa033200.10289237
93Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.09372005
94GnRH signaling pathway_Homo sapiens_hsa049120.08713605
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.07677363
96Vibrio cholerae infection_Homo sapiens_hsa051100.07490361
97Sulfur metabolism_Homo sapiens_hsa009200.05550870
98Phospholipase D signaling pathway_Homo sapiens_hsa040720.05272941
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.05217624
100Fatty acid biosynthesis_Homo sapiens_hsa000610.04974857

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