BCCIP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)5.13884773
2DNA deamination (GO:0045006)4.64595233
3ribosomal small subunit assembly (GO:0000028)4.49611537
4maturation of SSU-rRNA (GO:0030490)4.47444429
5formation of translation preinitiation complex (GO:0001731)4.39116288
6nucleobase biosynthetic process (GO:0046112)4.34042476
7purine nucleobase biosynthetic process (GO:0009113)4.26217252
8cullin deneddylation (GO:0010388)4.20570621
9ribosomal small subunit biogenesis (GO:0042274)4.14531498
10negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.99264744
11protein deneddylation (GO:0000338)3.95742114
12ribosomal large subunit biogenesis (GO:0042273)3.95083032
13chaperone-mediated protein transport (GO:0072321)3.93927233
14L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.92875285
15ribosome assembly (GO:0042255)3.92865283
16mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.86142317
17regulation of cellular amino acid metabolic process (GO:0006521)3.81192326
18positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.80749381
19mitotic metaphase plate congression (GO:0007080)3.80333866
20transcription elongation from RNA polymerase III promoter (GO:0006385)3.80244009
21termination of RNA polymerase III transcription (GO:0006386)3.80244009
22histone exchange (GO:0043486)3.79968736
23ribonucleoprotein complex biogenesis (GO:0022613)3.77157354
24rRNA modification (GO:0000154)3.75146004
25protein localization to kinetochore (GO:0034501)3.74011009
26SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.70115261
27regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.69498461
28translational termination (GO:0006415)3.68890455
29viral transcription (GO:0019083)3.68489736
30DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.66692236
31L-methionine salvage (GO:0071267)3.66233978
32L-methionine biosynthetic process (GO:0071265)3.66233978
33amino acid salvage (GO:0043102)3.66233978
34cotranslational protein targeting to membrane (GO:0006613)3.65529560
35anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.64157768
36ribosome biogenesis (GO:0042254)3.63605231
37DNA replication-independent nucleosome assembly (GO:0006336)3.63257196
38DNA replication-independent nucleosome organization (GO:0034724)3.63257196
39DNA damage response, detection of DNA damage (GO:0042769)3.62884253
40folic acid-containing compound biosynthetic process (GO:0009396)3.61645812
41translation (GO:0006412)3.61290189
42negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.61151120
43negative regulation of ligase activity (GO:0051352)3.61151120
44protein targeting to ER (GO:0045047)3.60913461
45intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.60441173
46signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.60441173
47signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.58856725
48signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.58856725
49signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.58856725
50IMP biosynthetic process (GO:0006188)3.58601890
51signal transduction involved in DNA integrity checkpoint (GO:0072401)3.53928122
52signal transduction involved in DNA damage checkpoint (GO:0072422)3.53928122
53DNA strand elongation involved in DNA replication (GO:0006271)3.52964773
54regulation of mitochondrial translation (GO:0070129)3.52400293
55DNA ligation (GO:0006266)3.52348417
56telomere maintenance via semi-conservative replication (GO:0032201)3.50098137
57signal transduction involved in cell cycle checkpoint (GO:0072395)3.49868355
58pseudouridine synthesis (GO:0001522)3.47976958
59protein localization to endoplasmic reticulum (GO:0070972)3.47916321
60rRNA processing (GO:0006364)3.46616881
61ATP synthesis coupled proton transport (GO:0015986)3.45472535
62energy coupled proton transport, down electrochemical gradient (GO:0015985)3.45472535
63translational elongation (GO:0006414)3.45189619
647-methylguanosine mRNA capping (GO:0006370)3.44949520
65antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.44805058
66metaphase plate congression (GO:0051310)3.41815748
67DNA strand elongation (GO:0022616)3.40789167
68establishment of integrated proviral latency (GO:0075713)3.39935425
69DNA double-strand break processing (GO:0000729)3.39600438
70establishment of protein localization to endoplasmic reticulum (GO:0072599)3.38919731
71establishment of protein localization to mitochondrial membrane (GO:0090151)3.38790669
72translational initiation (GO:0006413)3.38473855
73mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.37248661
747-methylguanosine RNA capping (GO:0009452)3.37224687
75RNA capping (GO:0036260)3.37224687
76cellular component biogenesis (GO:0044085)3.36230401
77mitotic recombination (GO:0006312)3.35803883
78regulation of helicase activity (GO:0051095)3.35245528
79positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.34479060
80spliceosomal snRNP assembly (GO:0000387)3.33584082
81oxidative phosphorylation (GO:0006119)3.33314716
82rRNA metabolic process (GO:0016072)3.32930807
83regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.26188613
84regulation of mitotic spindle checkpoint (GO:1903504)3.26188613
85exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.25337468
86DNA replication initiation (GO:0006270)3.24571601
87DNA catabolic process, exonucleolytic (GO:0000738)3.23447447
88CENP-A containing nucleosome assembly (GO:0034080)3.21181994
89positive regulation of ligase activity (GO:0051351)3.20970758
90antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.19400618
91nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.19382679
92transcription-coupled nucleotide-excision repair (GO:0006283)3.16933012
93protein localization to chromosome, centromeric region (GO:0071459)3.15639341
94deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.15303872
95DNA replication-dependent nucleosome organization (GO:0034723)3.14515943
96DNA replication-dependent nucleosome assembly (GO:0006335)3.14515943
97transcription from RNA polymerase I promoter (GO:0006360)3.14245166
98respiratory electron transport chain (GO:0022904)3.13785532
99pteridine-containing compound biosynthetic process (GO:0042559)3.12161776
100transcription elongation from RNA polymerase I promoter (GO:0006362)3.11723664
101chromatin remodeling at centromere (GO:0031055)3.11480564
102protein targeting to mitochondrion (GO:0006626)3.10546909
103termination of RNA polymerase I transcription (GO:0006363)3.09943521
104kinetochore organization (GO:0051383)3.09421378
105folic acid metabolic process (GO:0046655)3.09406605
106methionine biosynthetic process (GO:0009086)3.07594435
107nucleotide-excision repair, DNA gap filling (GO:0006297)3.07419817
108maturation of 5.8S rRNA (GO:0000460)3.07124883
109double-strand break repair via nonhomologous end joining (GO:0006303)3.06939178
110non-recombinational repair (GO:0000726)3.06939178
111mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.06836855
112mitochondrial respiratory chain complex I assembly (GO:0032981)3.06836855
113NADH dehydrogenase complex assembly (GO:0010257)3.06836855
114electron transport chain (GO:0022900)3.05989706
115spindle checkpoint (GO:0031577)3.05967744
116telomere maintenance via recombination (GO:0000722)3.05723920
117mitotic sister chromatid segregation (GO:0000070)3.05600415
118IMP metabolic process (GO:0046040)3.03790285
119negative regulation of mitotic sister chromatid separation (GO:2000816)3.03193332
120negative regulation of sister chromatid segregation (GO:0033046)3.03193332
121negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.03193332
122negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.03193332
123negative regulation of mitotic sister chromatid segregation (GO:0033048)3.03193332
124mitotic spindle checkpoint (GO:0071174)3.02179865
125DNA replication checkpoint (GO:0000076)3.01945219
126mitochondrial respiratory chain complex assembly (GO:0033108)3.01938426
127protein neddylation (GO:0045116)3.01875529
128telomere maintenance via telomere lengthening (GO:0010833)3.01733796
129methionine metabolic process (GO:0006555)3.01648509
130rRNA methylation (GO:0031167)3.01071820
131negative regulation of chromosome segregation (GO:0051985)3.00057929
132regulation of ubiquitin-protein transferase activity (GO:0051438)2.99927191
133cell cycle G1/S phase transition (GO:0044843)2.98593459
134G1/S transition of mitotic cell cycle (GO:0000082)2.98593459
135somatic hypermutation of immunoglobulin genes (GO:0016446)2.94498175
136nucleobase-containing small molecule interconversion (GO:0015949)2.93956157
137establishment of protein localization to mitochondrion (GO:0072655)2.92683529
138deoxyribonucleotide biosynthetic process (GO:0009263)2.92336480
139viral life cycle (GO:0019058)2.92059399
140establishment of viral latency (GO:0019043)2.91516684
1412-deoxyribonucleotide biosynthetic process (GO:0009265)2.91298245
142deoxyribose phosphate biosynthetic process (GO:0046385)2.91298245

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.21467545
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.53167821
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.50480759
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.95971080
5* EST1_17652178_ChIP-ChIP_JURKAT_Human3.94844917
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.78412416
7* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.73554323
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.44025862
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.42983257
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.32131292
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.07232517
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.94785416
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.87522351
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.86827368
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.78690746
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.71673274
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.68845148
18VDR_23849224_ChIP-Seq_CD4+_Human2.58842887
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.58267427
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.57156506
21SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.46948124
22E2F1_18555785_ChIP-Seq_MESCs_Mouse2.40535820
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.38398209
24XRN2_22483619_ChIP-Seq_HELA_Human2.33462629
25DCP1A_22483619_ChIP-Seq_HELA_Human2.30997557
26FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.30614185
27* FOXP3_21729870_ChIP-Seq_TREG_Human2.20817242
28THAP11_20581084_ChIP-Seq_MESCs_Mouse2.19657083
29SRF_21415370_ChIP-Seq_HL-1_Mouse2.17431527
30* PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.15779620
31ELK1_19687146_ChIP-ChIP_HELA_Human2.11162144
32PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.09668650
33GABP_19822575_ChIP-Seq_HepG2_Human2.04353821
34CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.87721813
35TTF2_22483619_ChIP-Seq_HELA_Human1.85447823
36CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.85392202
37YY1_21170310_ChIP-Seq_MESCs_Mouse1.85232167
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.82331846
39* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.79555732
40MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.75059411
41* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.74326388
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.71328496
43YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.71098480
44MYCN_18555785_ChIP-Seq_MESCs_Mouse1.69101041
45FOXM1_23109430_ChIP-Seq_U2OS_Human1.67419663
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.66659252
47NANOG_18555785_ChIP-Seq_MESCs_Mouse1.59263231
48CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.58809263
49MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.55362372
50SALL1_21062744_ChIP-ChIP_HESCs_Human1.54399495
51ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.51590404
52ZFX_18555785_ChIP-Seq_MESCs_Mouse1.50223486
53PADI4_21655091_ChIP-ChIP_MCF-7_Human1.46314025
54* AR_21909140_ChIP-Seq_LNCAP_Human1.45685023
55POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.39623118
56EWS_26573619_Chip-Seq_HEK293_Human1.37894003
57HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.37656519
58KDM5A_27292631_Chip-Seq_BREAST_Human1.37465478
59E2F1_21310950_ChIP-Seq_MCF-7_Human1.36940340
60* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.35697188
61FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.32593677
62ERG_20887958_ChIP-Seq_HPC-7_Mouse1.29775415
63EGR1_23403033_ChIP-Seq_LIVER_Mouse1.28670828
64BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.27781451
65ELK1_22589737_ChIP-Seq_MCF10A_Human1.24414424
66ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.22582913
67RBPJ_22232070_ChIP-Seq_NCS_Mouse1.22045249
68MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.21739011
69STAT3_1855785_ChIP-Seq_MESCs_Mouse1.21481051
70FUS_26573619_Chip-Seq_HEK293_Human1.17492258
71NANOG_16153702_ChIP-ChIP_HESCs_Human1.16678915
72POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.16202989
73* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.15890990
74CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.15324661
75CIITA_25753668_ChIP-Seq_RAJI_Human1.11478595
76POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11164901
77SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.10282764
78MYC_18940864_ChIP-ChIP_HL60_Human1.10160251
79CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.07350514
80SOX2_16153702_ChIP-ChIP_HESCs_Human1.06816707
81DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.05386932
82PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.04757215
83CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.04755627
84TFEB_21752829_ChIP-Seq_HELA_Human1.02613425
85NOTCH1_21737748_ChIP-Seq_TLL_Human1.01876952
86CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.01125448
87IRF1_19129219_ChIP-ChIP_H3396_Human0.99803420
88HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.98795473
89ZNF274_21170338_ChIP-Seq_K562_Hela0.96074055
90SOX2_18555785_ChIP-Seq_MESCs_Mouse0.94455848
91* SOX17_20123909_ChIP-Seq_XEN_Mouse0.94407416
92HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.93567104
93KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.90817134
94E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.90801438
95CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.85661385
96* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.85072085
97OCT4_18692474_ChIP-Seq_MEFs_Mouse0.85048620
98TP63_19390658_ChIP-ChIP_HaCaT_Human0.84721409
99VDR_22108803_ChIP-Seq_LS180_Human0.81968655
100SOX2_18692474_ChIP-Seq_MEFs_Mouse0.80929098
101TCF3_18692474_ChIP-Seq_MEFs_Mouse0.80539016
102GATA1_22025678_ChIP-Seq_K562_Human0.80258101
103SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.80157016
104NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.79956774
105SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.79126722
106PPARA_22158963_ChIP-Seq_LIVER_Mouse0.76482426
107SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.75614879
108SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.75197808
109GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.74208524
110KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.72391428
111KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.72391428
112KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.72391428
113IGF1R_20145208_ChIP-Seq_DFB_Human0.72054413
114TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.70595155
115FLI1_27457419_Chip-Seq_LIVER_Mouse0.70180626
116ESR1_15608294_ChIP-ChIP_MCF-7_Human0.68664236
117RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.68352268
118POU3F2_20337985_ChIP-ChIP_501MEL_Human0.65174286

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis5.26651428
2MP0003693_abnormal_embryo_hatching5.13577925
3MP0004957_abnormal_blastocyst_morpholog4.58617270
4MP0010094_abnormal_chromosome_stability3.43907758
5MP0002139_abnormal_hepatobiliary_system3.42025569
6MP0008058_abnormal_DNA_repair3.17929161
7MP0008057_abnormal_DNA_replication3.08491881
8MP0003111_abnormal_nucleus_morphology2.98247364
9MP0003077_abnormal_cell_cycle2.97318499
10MP0003195_calcinosis2.91139819
11MP0003186_abnormal_redox_activity2.76918725
12MP0005085_abnormal_gallbladder_physiolo2.73188654
13MP0005365_abnormal_bile_salt2.58415900
14MP0008932_abnormal_embryonic_tissue2.47885920
15MP0006036_abnormal_mitochondrial_physio2.32448344
16MP0003718_maternal_effect2.29509846
17MP0008007_abnormal_cellular_replicative2.25590093
18MP0008875_abnormal_xenobiotic_pharmacok2.11570563
19MP0003786_premature_aging2.09997455
20MP0001764_abnormal_homeostasis2.07685118
21MP0009697_abnormal_copulation2.05552831
22MP0003123_paternal_imprinting2.03809960
23MP0006035_abnormal_mitochondrial_morpho1.99707321
24MP0001293_anophthalmia1.98239712
25MP0005360_urolithiasis1.96833713
26MP0006072_abnormal_retinal_apoptosis1.74891357
27MP0009379_abnormal_foot_pigmentation1.69783860
28MP0008789_abnormal_olfactory_epithelium1.61967107
29MP0001730_embryonic_growth_arrest1.58855801
30MP0005083_abnormal_biliary_tract1.45253825
31MP0003937_abnormal_limbs/digits/tail_de1.40225789
32MP0005332_abnormal_amino_acid1.39344889
33MP0002396_abnormal_hematopoietic_system1.35471097
34MP0002102_abnormal_ear_morphology1.35004807
35MP0008995_early_reproductive_senescence1.33150739
36MP0000350_abnormal_cell_proliferation1.29830726
37MP0005408_hypopigmentation1.28993389
38MP0004147_increased_porphyrin_level1.27907255
39MP0003121_genomic_imprinting1.22418051
40MP0001929_abnormal_gametogenesis1.18569077
41MP0003656_abnormal_erythrocyte_physiolo1.16408518
42MP0001666_abnormal_nutrient_absorption1.16115204
43MP0001697_abnormal_embryo_size1.14921372
44MP0002132_abnormal_respiratory_system1.14489497
45MP0006054_spinal_hemorrhage1.13863809
46MP0000358_abnormal_cell_content/1.13807330
47MP0002080_prenatal_lethality1.13381153
48MP0005499_abnormal_olfactory_system1.11990305
49MP0005394_taste/olfaction_phenotype1.11990305
50MP0000313_abnormal_cell_death1.11524568
51MP0001286_abnormal_eye_development1.10937353
52MP0005266_abnormal_metabolism1.10554955
53MP0003136_yellow_coat_color1.09613990
54MP0004043_abnormal_pH_regulation1.08885100
55MP0005389_reproductive_system_phenotype1.08372568
56MP0003315_abnormal_perineum_morphology1.07894360
57MP0002233_abnormal_nose_morphology1.07401948
58MP0005319_abnormal_enzyme/_coenzyme1.05768921
59MP0005636_abnormal_mineral_homeostasis1.04880458
60MP0002697_abnormal_eye_size1.03094879
61MP0003119_abnormal_digestive_system1.03014905
62MP0008877_abnormal_DNA_methylation1.01647251
63MP0005380_embryogenesis_phenotype0.99920934
64MP0001672_abnormal_embryogenesis/_devel0.99920934
65MP0010307_abnormal_tumor_latency0.98566894
66MP0002019_abnormal_tumor_incidence0.98423191
67MP0002938_white_spotting0.97470875
68MP0009333_abnormal_splenocyte_physiolog0.96971415
69MP0001542_abnormal_bone_strength0.96921421
70MP0000372_irregular_coat_pigmentation0.96772879
71MP0004019_abnormal_vitamin_homeostasis0.94242354
72MP0002234_abnormal_pharynx_morphology0.92477360
73MP0001919_abnormal_reproductive_system0.92239336
74MP0006292_abnormal_olfactory_placode0.92157805
75MP0005376_homeostasis/metabolism_phenot0.91767132
76MP0003984_embryonic_growth_retardation0.91054415
77MP0001188_hyperpigmentation0.90999740
78MP0003763_abnormal_thymus_physiology0.89796646
79MP0005084_abnormal_gallbladder_morpholo0.89742564
80MP0009643_abnormal_urine_homeostasis0.88800780
81MP0002088_abnormal_embryonic_growth/wei0.87619356
82MP0002736_abnormal_nociception_after0.87249597
83MP0002111_abnormal_tail_morphology0.86983378
84MP0000598_abnormal_liver_morphology0.86773261
85MP0000647_abnormal_sebaceous_gland0.86559671
86MP0004133_heterotaxia0.86060598
87MP0001727_abnormal_embryo_implantation0.85980258
88MP0002160_abnormal_reproductive_system0.85534815
89MP0005075_abnormal_melanosome_morpholog0.84364381
90MP0002876_abnormal_thyroid_physiology0.81048294
91MP0005379_endocrine/exocrine_gland_phen0.80539030
92MP0000537_abnormal_urethra_morphology0.80288969
93MP0000631_abnormal_neuroendocrine_gland0.79768481
94MP0001529_abnormal_vocalization0.79455259
95MP0002751_abnormal_autonomic_nervous0.78485494
96MP0000049_abnormal_middle_ear0.77809056
97MP0005395_other_phenotype0.77429191
98MP0010329_abnormal_lipoprotein_level0.76057049
99MP0000490_abnormal_crypts_of0.75690580
100MP0005253_abnormal_eye_physiology0.75646042
101MP0003698_abnormal_male_reproductive0.75565737
102MP0001243_abnormal_dermal_layer0.75165916
103MP0005391_vision/eye_phenotype0.74040667
104MP0009703_decreased_birth_body0.73801570
105MP0002086_abnormal_extraembryonic_tissu0.73642995
106MP0000609_abnormal_liver_physiology0.73571220
107MP0002163_abnormal_gland_morphology0.73452566
108MP0001984_abnormal_olfaction0.72177104
109MP0002090_abnormal_vision0.72079986
110MP0003221_abnormal_cardiomyocyte_apopto0.71671878
111MP0002837_dystrophic_cardiac_calcinosis0.71598670
112MP0002085_abnormal_embryonic_tissue0.70568790
113MP0005220_abnormal_exocrine_pancreas0.69831347
114MP0000749_muscle_degeneration0.69779228
115MP0000689_abnormal_spleen_morphology0.69314788
116MP0010030_abnormal_orbit_morphology0.68746300
117MP0004215_abnormal_myocardial_fiber0.68127699
118MP0002269_muscular_atrophy0.68002675
119MP0001853_heart_inflammation0.67869242
120MP0001485_abnormal_pinna_reflex0.67678012
121MP0003755_abnormal_palate_morphology0.66778878
122MP0008873_increased_physiological_sensi0.66295335
123MP0008260_abnormal_autophagy0.65855036
124MP0003890_abnormal_embryonic-extraembry0.65701129
125MP0003567_abnormal_fetal_cardiomyocyte0.65430576
126MP0003861_abnormal_nervous_system0.64778420
127MP0005187_abnormal_penis_morphology0.64727965
128MP0003941_abnormal_skin_development0.64669001
129MP0004197_abnormal_fetal_growth/weight/0.64476819
130MP0001661_extended_life_span0.64216820
131MP0001145_abnormal_male_reproductive0.63462023
132MP0001119_abnormal_female_reproductive0.62873454
133MP0002722_abnormal_immune_system0.61224474
134MP0002210_abnormal_sex_determination0.61219525
135MP0002084_abnormal_developmental_patter0.61161147
136MP0004782_abnormal_surfactant_physiolog0.60968075
137MP0002282_abnormal_trachea_morphology0.60083532
138MP0002161_abnormal_fertility/fecundity0.59201662
139MP0002092_abnormal_eye_morphology0.59180715
140MP0002095_abnormal_skin_pigmentation0.58147358
141MP0001986_abnormal_taste_sensitivity0.58059390
142MP0000653_abnormal_sex_gland0.57936688
143MP0009672_abnormal_birth_weight0.57595774

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.56701520
2Abnormal mitochondria in muscle tissue (HP:0008316)4.23823613
3Acute encephalopathy (HP:0006846)4.10692393
4Birth length less than 3rd percentile (HP:0003561)4.07986902
5Mitochondrial inheritance (HP:0001427)4.00358878
6Increased CSF lactate (HP:0002490)3.84505295
73-Methylglutaconic aciduria (HP:0003535)3.76579683
8Hepatic necrosis (HP:0002605)3.66050913
9Chromosomal breakage induced by crosslinking agents (HP:0003221)3.63889605
10Hepatocellular necrosis (HP:0001404)3.60412662
11Chromsome breakage (HP:0040012)3.57871509
12Abnormality of glycolysis (HP:0004366)3.57566981
13Increased serum pyruvate (HP:0003542)3.57566981
14Abnormality of cells of the erythroid lineage (HP:0012130)3.50342533
15Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.48537645
16Decreased activity of mitochondrial respiratory chain (HP:0008972)3.48537645
17Progressive macrocephaly (HP:0004481)3.48526378
18Cerebral edema (HP:0002181)3.40861544
19Breast hypoplasia (HP:0003187)3.36934981
20Abnormal number of erythroid precursors (HP:0012131)3.36303796
21Increased serum lactate (HP:0002151)3.33201034
22Colon cancer (HP:0003003)3.29992412
23Cerebral hypomyelination (HP:0006808)3.26729913
24Oral leukoplakia (HP:0002745)3.23673103
25Meckel diverticulum (HP:0002245)3.14715598
26Hypobetalipoproteinemia (HP:0003563)3.08694704
27Lactic acidosis (HP:0003128)2.97967929
28Abnormality of the ileum (HP:0001549)2.96473997
29Abnormality of the labia minora (HP:0012880)2.95811430
30Macrocytic anemia (HP:0001972)2.95644631
31Rough bone trabeculation (HP:0100670)2.93813071
32Reticulocytopenia (HP:0001896)2.91695917
33Abnormality of chromosome stability (HP:0003220)2.90506218
34Secondary amenorrhea (HP:0000869)2.89793327
35Increased hepatocellular lipid droplets (HP:0006565)2.80796207
36Aplasia/Hypoplasia of the uvula (HP:0010293)2.79634976
37Lipid accumulation in hepatocytes (HP:0006561)2.78941500
38Abnormality of the preputium (HP:0100587)2.78884823
39Carpal bone hypoplasia (HP:0001498)2.76843935
40Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.71133846
41Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.70716531
42Lethargy (HP:0001254)2.70096199
43Abnormality of aromatic amino acid family metabolism (HP:0004338)2.70048572
44Exercise intolerance (HP:0003546)2.69854074
45Aplastic anemia (HP:0001915)2.67242869
46Abnormal lung lobation (HP:0002101)2.65364253
47Respiratory failure (HP:0002878)2.58730043
48Type I transferrin isoform profile (HP:0003642)2.54274960
49Nausea (HP:0002018)2.52014710
50CNS demyelination (HP:0007305)2.48130787
51Degeneration of anterior horn cells (HP:0002398)2.45245697
52Abnormality of the anterior horn cell (HP:0006802)2.45245697
53Duodenal stenosis (HP:0100867)2.44303030
54Small intestinal stenosis (HP:0012848)2.44303030
55Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.43023102
56Abnormality of alanine metabolism (HP:0010916)2.43023102
57Hyperalaninemia (HP:0003348)2.43023102
58Irregular epiphyses (HP:0010582)2.41122733
59Abnormality of monocarboxylic acid metabolism (HP:0010996)2.37029861
60Multiple enchondromatosis (HP:0005701)2.35151110
61Abnormality of methionine metabolism (HP:0010901)2.32906883
62Renal Fanconi syndrome (HP:0001994)2.32566165
63Hyperglycinemia (HP:0002154)2.31771768
64Generalized aminoaciduria (HP:0002909)2.31670573
65Abnormality of serum amino acid levels (HP:0003112)2.31051259
66Increased intramyocellular lipid droplets (HP:0012240)2.29406995
67Megaloblastic anemia (HP:0001889)2.25893886
68Intrahepatic cholestasis (HP:0001406)2.25424505
69Microretrognathia (HP:0000308)2.25023560
70Leukodystrophy (HP:0002415)2.23520371
71Volvulus (HP:0002580)2.21260455
72Abnormality of pyrimidine metabolism (HP:0004353)2.21105717
73Microvesicular hepatic steatosis (HP:0001414)2.20139105
74Premature graying of hair (HP:0002216)2.19192557
75Triphalangeal thumb (HP:0001199)2.16716019
76Abnormality of the duodenum (HP:0002246)2.16486047
77Abnormal trabecular bone morphology (HP:0100671)2.16446902
78Hypoglycemic coma (HP:0001325)2.15222703
79Sparse eyelashes (HP:0000653)2.11809058
80Myelodysplasia (HP:0002863)2.10884849
81Methylmalonic acidemia (HP:0002912)2.10656848
82CNS hypomyelination (HP:0003429)2.10065847
83Horseshoe kidney (HP:0000085)2.08611890
84Medulloblastoma (HP:0002885)2.07638729
85Increased muscle lipid content (HP:0009058)2.07390156
86Poor head control (HP:0002421)2.03746169
87Nephroblastoma (Wilms tumor) (HP:0002667)2.02921349
88Premature ovarian failure (HP:0008209)1.99873280
89Pallor (HP:0000980)1.99498235
90Respiratory difficulties (HP:0002880)1.99226807
91Gonadotropin excess (HP:0000837)1.98577050
92Absent thumb (HP:0009777)1.98470206
93Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.97391298
94Abnormality of dicarboxylic acid metabolism (HP:0010995)1.96915819
95Dicarboxylic aciduria (HP:0003215)1.96915819
96Septo-optic dysplasia (HP:0100842)1.96261431
97Abnormality of the heme biosynthetic pathway (HP:0010472)1.96062947
98Sloping forehead (HP:0000340)1.95890350
99Embryonal renal neoplasm (HP:0011794)1.95278569
100Cellular immunodeficiency (HP:0005374)1.95226082
101Aplasia/Hypoplasia of the sacrum (HP:0008517)1.95013314
102Optic disc pallor (HP:0000543)1.92638118
103Abnormality of urine glucose concentration (HP:0011016)1.89568096
104Glycosuria (HP:0003076)1.89568096
105Abnormality of aspartate family amino acid metabolism (HP:0010899)1.88715378
106Opisthotonus (HP:0002179)1.87034974
107Neoplasm of the colon (HP:0100273)1.86201045
108Abnormal protein glycosylation (HP:0012346)1.85978909
109Abnormal glycosylation (HP:0012345)1.85978909
110Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.85978909
111Abnormal protein N-linked glycosylation (HP:0012347)1.85978909
112Rhabdomyosarcoma (HP:0002859)1.85589992
113Trismus (HP:0000211)1.84605197
114Pancytopenia (HP:0001876)1.84562660
115Hyperglycinuria (HP:0003108)1.84210155
116Emotional lability (HP:0000712)1.83534986
117Exertional dyspnea (HP:0002875)1.83219293
118Absent radius (HP:0003974)1.83111336
119Ependymoma (HP:0002888)1.83016005
120Patellar aplasia (HP:0006443)1.80658602
121Stenosis of the external auditory canal (HP:0000402)1.80603786
122Abnormality of fatty-acid metabolism (HP:0004359)1.80222089
123Hyperammonemia (HP:0001987)1.80080126
124Testicular atrophy (HP:0000029)1.80000011
125Abnormality of serine family amino acid metabolism (HP:0010894)1.79463130
126Abnormality of glycine metabolism (HP:0010895)1.79463130
127Supernumerary spleens (HP:0009799)1.78404711
128Prolonged partial thromboplastin time (HP:0003645)1.77803625
12911 pairs of ribs (HP:0000878)1.77246578
130Pancreatic fibrosis (HP:0100732)1.76438365
131Aplasia involving forearm bones (HP:0009822)1.74983693
132Absent forearm bone (HP:0003953)1.74983693
133Methylmalonic aciduria (HP:0012120)1.73241197
134Postnatal microcephaly (HP:0005484)1.72634755
135True hermaphroditism (HP:0010459)1.72097003
136Progressive muscle weakness (HP:0003323)1.71167648
137Absent septum pellucidum (HP:0001331)1.70807281
138Pancreatic cysts (HP:0001737)1.70475289
139Abnormality of the carotid arteries (HP:0005344)1.68937968
140Abnormality of midbrain morphology (HP:0002418)1.68855416
141Molar tooth sign on MRI (HP:0002419)1.68855416

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK14.52916236
2STK164.47781544
3BUB14.34022212
4VRK23.38546087
5WEE13.33058842
6TSSK63.29368912
7EIF2AK33.09931327
8NME22.77471181
9SRPK12.41183710
10BCKDK2.29308399
11VRK12.22391288
12PLK42.22033503
13TESK22.03461961
14CDC72.03295823
15BRSK21.92805324
16NME11.85103705
17NUAK11.76171538
18NEK11.74872995
19TRIM281.72227715
20AKT31.68285071
21MKNK11.64854667
22ACVR1B1.64710042
23PASK1.62335483
24PLK31.57832111
25MST41.54793920
26MAPKAPK31.51018215
27TAF11.50795723
28PLK11.44908700
29KDR1.41715796
30TTK1.40160440
31PIM21.39639829
32PBK1.38350987
33TNIK1.30156597
34RPS6KB21.28627327
35EPHA21.28505110
36BRAF1.28353404
37AURKB1.22086253
38MKNK21.21026911
39ZAK1.20145183
40BMPR1B1.15924749
41WNK31.13316004
42MAP4K21.09250003
43AURKA1.06078559
44BRSK11.04054631
45TLK11.03026149
46ATR1.02113213
47CDK80.97229832
48CDK70.95105278
49ERBB30.94745525
50DAPK10.88730791
51NEK20.87458558
52CSNK2A10.87127372
53CSNK2A20.86091646
54DYRK30.86081539
55CSNK1G10.85829604
56ALK0.81441488
57CCNB10.81015888
58STK38L0.80711436
59MAP3K30.80004067
60PDK20.78042704
61TESK10.77244545
62CSNK1G20.76392835
63MAP3K110.72059783
64CHEK20.71619383
65EIF2AK20.71244976
66TXK0.71078552
67PDK30.69890631
68PDK40.69890631
69NEK90.69878125
70MYLK0.69091232
71CHEK10.67949182
72MAP3K80.65056810
73TGFBR10.64631506
74CSNK1A1L0.64058073
75RPS6KA40.63970497
76IRAK30.63390276
77CDK190.63220710
78FLT30.62257896
79MAP3K120.56937220
80STK30.56847211
81BCR0.56463423
82ARAF0.55634796
83SCYL20.55350453
84RPS6KA50.54330064
85PRKCI0.53943088
86ABL20.53719279
87ATM0.53195813
88PIM10.52952555
89STK40.52893745
90MAP3K40.52352342
91DYRK20.51975849
92CLK10.50878449
93LIMK10.50829418
94STK390.48249993
95ERBB40.46714832
96PAK40.46184496
97CDK20.45582629
98MAP4K10.44364439
99CDK30.44246747
100TEC0.44219530
101PLK20.42210624
102MAP2K70.40367121
103OXSR10.38378427
104PRKDC0.36474160
105OBSCN0.36319538
106PIK3CG0.36096566
107CDK10.34356496
108MINK10.32751276
109ADRBK20.32367904
110GRK10.31782202
111CDK40.31537419
112FGFR10.31359302
113INSRR0.30683971
114STK100.30361798
115BRD40.29432949
116STK240.29363803
117ZAP700.29073845
118PNCK0.28627571
119CDK90.27510863
120MET0.26575446
121BMPR20.25743057
122CSNK1E0.24814747
123CDK60.24650129
124AKT20.24491146
125PAK10.23953117
126ILK0.23697556
127PINK10.23511115
128CSNK1A10.22636756
129WNK40.22612556
130CDK140.22502514
131LYN0.20916081
132MAPKAPK20.20222066
133CSNK1G30.19852357

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.22811248
2Ribosome_Homo sapiens_hsa030103.60585015
3RNA polymerase_Homo sapiens_hsa030203.24785271
4DNA replication_Homo sapiens_hsa030303.19367210
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.97867958
6Mismatch repair_Homo sapiens_hsa034302.89812712
7Protein export_Homo sapiens_hsa030602.66308916
8Spliceosome_Homo sapiens_hsa030402.44854732
9Pyrimidine metabolism_Homo sapiens_hsa002402.36122447
10Oxidative phosphorylation_Homo sapiens_hsa001902.27837937
11One carbon pool by folate_Homo sapiens_hsa006702.20943731
12Nucleotide excision repair_Homo sapiens_hsa034202.19596418
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.14440468
14RNA transport_Homo sapiens_hsa030132.12781131
15Parkinsons disease_Homo sapiens_hsa050122.00712346
16Homologous recombination_Homo sapiens_hsa034401.90348580
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.85305658
18Base excision repair_Homo sapiens_hsa034101.82932607
19Basal transcription factors_Homo sapiens_hsa030221.59057926
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.57769122
21Folate biosynthesis_Homo sapiens_hsa007901.55257940
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.54861110
23Huntingtons disease_Homo sapiens_hsa050161.51252135
24Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.49169075
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.47779369
26RNA degradation_Homo sapiens_hsa030181.44816734
27Selenocompound metabolism_Homo sapiens_hsa004501.44169180
28Non-homologous end-joining_Homo sapiens_hsa034501.43255535
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.42924926
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.36081903
31Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.29658829
32Purine metabolism_Homo sapiens_hsa002301.23645869
33Cell cycle_Homo sapiens_hsa041101.23187715
34Alzheimers disease_Homo sapiens_hsa050101.20426041
35Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.20215618
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.16175073
37Fanconi anemia pathway_Homo sapiens_hsa034601.15485702
38Glutathione metabolism_Homo sapiens_hsa004801.10924842
39Biosynthesis of amino acids_Homo sapiens_hsa012301.10900284
40Vitamin B6 metabolism_Homo sapiens_hsa007501.10249162
41Primary bile acid biosynthesis_Homo sapiens_hsa001201.09296532
42Maturity onset diabetes of the young_Homo sapiens_hsa049501.09231388
43Sulfur metabolism_Homo sapiens_hsa009201.08552213
44Carbon metabolism_Homo sapiens_hsa012001.08453735
45Cyanoamino acid metabolism_Homo sapiens_hsa004601.08304583
46Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.08128453
47Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.04497635
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.99350651
49Pyruvate metabolism_Homo sapiens_hsa006200.99029846
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.95305835
51Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.94156924
52Cardiac muscle contraction_Homo sapiens_hsa042600.93407692
53Propanoate metabolism_Homo sapiens_hsa006400.92326652
54Oocyte meiosis_Homo sapiens_hsa041140.87748194
55Chemical carcinogenesis_Homo sapiens_hsa052040.86951719
56Fatty acid elongation_Homo sapiens_hsa000620.86597859
57Peroxisome_Homo sapiens_hsa041460.85433297
58Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.84619813
59Fructose and mannose metabolism_Homo sapiens_hsa000510.81184826
60Phenylalanine metabolism_Homo sapiens_hsa003600.80198452
61Sulfur relay system_Homo sapiens_hsa041220.79880664
62Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.78926487
63Metabolic pathways_Homo sapiens_hsa011000.78752227
64Tyrosine metabolism_Homo sapiens_hsa003500.76657753
65Pentose phosphate pathway_Homo sapiens_hsa000300.75703519
66Tryptophan metabolism_Homo sapiens_hsa003800.73555573
67Arginine and proline metabolism_Homo sapiens_hsa003300.71122502
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.70976260
69Epstein-Barr virus infection_Homo sapiens_hsa051690.70348872
70Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.70312175
71Pentose and glucuronate interconversions_Homo sapiens_hsa000400.68489611
72mRNA surveillance pathway_Homo sapiens_hsa030150.68169813
73Histidine metabolism_Homo sapiens_hsa003400.67375965
74Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.67348620
75Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67136145
76Fatty acid degradation_Homo sapiens_hsa000710.65837418
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.62016865
78p53 signaling pathway_Homo sapiens_hsa041150.61407758
79beta-Alanine metabolism_Homo sapiens_hsa004100.59238478
80Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.57525257
81Galactose metabolism_Homo sapiens_hsa000520.56625249
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55744686
83Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.54687097
84Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.49886029
85Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.48701794
86Arachidonic acid metabolism_Homo sapiens_hsa005900.47946200
87Butanoate metabolism_Homo sapiens_hsa006500.46047785
88Retinol metabolism_Homo sapiens_hsa008300.45846917
89Regulation of autophagy_Homo sapiens_hsa041400.44192709
90Caffeine metabolism_Homo sapiens_hsa002320.40590834
91Linoleic acid metabolism_Homo sapiens_hsa005910.40522116
92Systemic lupus erythematosus_Homo sapiens_hsa053220.40396241
93Steroid biosynthesis_Homo sapiens_hsa001000.39324427
94N-Glycan biosynthesis_Homo sapiens_hsa005100.35976500
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34979814
96Antigen processing and presentation_Homo sapiens_hsa046120.34821896
97Steroid hormone biosynthesis_Homo sapiens_hsa001400.34565956
98Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.32041736
99Fat digestion and absorption_Homo sapiens_hsa049750.31848516
100Legionellosis_Homo sapiens_hsa051340.31312935
101Complement and coagulation cascades_Homo sapiens_hsa046100.30291387
102Phototransduction_Homo sapiens_hsa047440.30190852
103Arginine biosynthesis_Homo sapiens_hsa002200.27767026
104TGF-beta signaling pathway_Homo sapiens_hsa043500.27264643
105Vitamin digestion and absorption_Homo sapiens_hsa049770.26369906
106Herpes simplex infection_Homo sapiens_hsa051680.25328029
107Fatty acid metabolism_Homo sapiens_hsa012120.25263529
108Nitrogen metabolism_Homo sapiens_hsa009100.23888008
109Basal cell carcinoma_Homo sapiens_hsa052170.22465147
110Hedgehog signaling pathway_Homo sapiens_hsa043400.18636038
111Wnt signaling pathway_Homo sapiens_hsa043100.14542186
112Hippo signaling pathway_Homo sapiens_hsa043900.14095587
113Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.09667383
114Lysine degradation_Homo sapiens_hsa003100.05192240
115Collecting duct acid secretion_Homo sapiens_hsa049660.04479040
116Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.04048873

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