BCAT2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a branched chain aminotransferase found in mitochondria. The encoded protein forms a dimer that catalyzes the first step in the production of the branched chain amino acids leucine, isoleucine, and valine. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* valine metabolic process (GO:0006573)4.68165838
2deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.67871848
3regulation of mitochondrial translation (GO:0070129)4.58946834
4protein maturation by protein folding (GO:0022417)4.50273552
5* branched-chain amino acid catabolic process (GO:0009083)4.41112471
6* branched-chain amino acid metabolic process (GO:0009081)4.17580676
7lysine metabolic process (GO:0006553)3.95154764
8lysine catabolic process (GO:0006554)3.95154764
9regulation of sequestering of triglyceride (GO:0010889)3.82202373
102-oxoglutarate metabolic process (GO:0006103)3.78872635
11proteasome assembly (GO:0043248)3.76559504
12GDP-mannose metabolic process (GO:0019673)3.75124815
13mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.72973858
14biotin metabolic process (GO:0006768)3.72264237
15DNA strand elongation (GO:0022616)3.70447271
16negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.68920057
17fatty acid beta-oxidation (GO:0006635)3.61869414
18peptidyl-arginine omega-N-methylation (GO:0035247)3.59779995
19guanosine-containing compound biosynthetic process (GO:1901070)3.59530500
20tricarboxylic acid cycle (GO:0006099)3.57044436
21UTP biosynthetic process (GO:0006228)3.46343282
22pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.46102106
23glycine metabolic process (GO:0006544)3.41485400
24ribosomal small subunit biogenesis (GO:0042274)3.39717517
25tricarboxylic acid metabolic process (GO:0072350)3.39410505
26low-density lipoprotein particle clearance (GO:0034383)3.34074142
27ATP synthesis coupled proton transport (GO:0015986)3.30686708
28energy coupled proton transport, down electrochemical gradient (GO:0015985)3.30686708
29pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.30163432
30pentose metabolic process (GO:0019321)3.30077520
31Golgi transport vesicle coating (GO:0048200)3.29166743
32COPI coating of Golgi vesicle (GO:0048205)3.29166743
33oxaloacetate metabolic process (GO:0006107)3.28992555
34sulfur amino acid catabolic process (GO:0000098)3.28857240
35homocysteine metabolic process (GO:0050667)3.28543379
36pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.25652795
37pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.25410234
38GTP biosynthetic process (GO:0006183)3.23047843
39regulation of translational fidelity (GO:0006450)3.22510116
40proline biosynthetic process (GO:0006561)3.22300778
41nucleobase-containing small molecule interconversion (GO:0015949)3.20741786
42negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.20023526
43protein targeting to mitochondrion (GO:0006626)3.18021147
44folic acid-containing compound biosynthetic process (GO:0009396)3.17819586
45fatty acid oxidation (GO:0019395)3.17563233
46cysteine metabolic process (GO:0006534)3.15849391
47nuclear envelope reassembly (GO:0031468)3.15810039
48mitotic nuclear envelope reassembly (GO:0007084)3.15810039
49UTP metabolic process (GO:0046051)3.14269680
50DNA unwinding involved in DNA replication (GO:0006268)3.13458509
51pseudouridine synthesis (GO:0001522)3.13050329
52gluconeogenesis (GO:0006094)3.12964693
53carnitine metabolic process (GO:0009437)3.12875475
54lipid oxidation (GO:0034440)3.11631900
55DNA deamination (GO:0045006)3.11136831
56NADH metabolic process (GO:0006734)3.11017245
57fatty acid catabolic process (GO:0009062)3.09012452
58aspartate family amino acid catabolic process (GO:0009068)3.08918677
59oxidative phosphorylation (GO:0006119)3.08916657
60CTP biosynthetic process (GO:0006241)3.07991868
61CTP metabolic process (GO:0046036)3.07991868
62rRNA modification (GO:0000154)3.07335059
63respiratory electron transport chain (GO:0022904)3.07249874
64establishment of protein localization to mitochondrial membrane (GO:0090151)3.07156892
65serine family amino acid biosynthetic process (GO:0009070)3.06151010
66base-excision repair, AP site formation (GO:0006285)3.04538555
67peptidyl-histidine modification (GO:0018202)3.03536885
68pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.03108588
69amino-acid betaine metabolic process (GO:0006577)3.02522173
70glyoxylate metabolic process (GO:0046487)3.01204227
71monosaccharide biosynthetic process (GO:0046364)3.00517771
72electron transport chain (GO:0022900)3.00476352
73negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.00318202
74negative regulation of ligase activity (GO:0051352)3.00318202
75pentose-phosphate shunt (GO:0006098)2.99013036
76rRNA transcription (GO:0009303)2.96811246
77GMP metabolic process (GO:0046037)2.95092137
78fatty acid transmembrane transport (GO:1902001)2.94351055
79establishment of protein localization to mitochondrion (GO:0072655)2.94215010
80peptidyl-arginine N-methylation (GO:0035246)2.93856284
81peptidyl-arginine methylation (GO:0018216)2.93856284
82serine family amino acid metabolic process (GO:0009069)2.93802640
83hexose biosynthetic process (GO:0019319)2.93515575
84ribosomal large subunit biogenesis (GO:0042273)2.93103764
85positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.92897574
86acetyl-CoA metabolic process (GO:0006084)2.91867079
87DNA replication initiation (GO:0006270)2.91580777
88regulation of cellular amino acid metabolic process (GO:0006521)2.90366463
89regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.90007210
90iron-sulfur cluster assembly (GO:0016226)2.89440843
91metallo-sulfur cluster assembly (GO:0031163)2.89440843
92proline metabolic process (GO:0006560)2.89000433
93histone arginine methylation (GO:0034969)2.88381164
94fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.87948608
95protein complex biogenesis (GO:0070271)2.87425098
96formation of translation preinitiation complex (GO:0001731)2.86663229
97mitochondrial respiratory chain complex assembly (GO:0033108)2.86525440
98carnitine shuttle (GO:0006853)2.86356512
99nucleoside transmembrane transport (GO:1901642)2.86277012
100pyrimidine nucleotide catabolic process (GO:0006244)2.85522520
101ribonucleoprotein complex biogenesis (GO:0022613)2.85369879
102folic acid metabolic process (GO:0046655)2.85055626
103anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.84825288
104mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.84349892
105IMP biosynthetic process (GO:0006188)2.82501154
106cullin deneddylation (GO:0010388)2.80998305
107NADPH regeneration (GO:0006740)2.80464475
108ethanol oxidation (GO:0006069)2.80076439
109pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.79940261
110telomere maintenance via recombination (GO:0000722)2.79777171
111serine family amino acid catabolic process (GO:0009071)2.76931505
112erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.75687762
113L-phenylalanine metabolic process (GO:0006558)2.75687762
114establishment of integrated proviral latency (GO:0075713)2.75255869
115base-excision repair (GO:0006284)2.74724002
116ribosome biogenesis (GO:0042254)2.73562306
117tRNA aminoacylation for protein translation (GO:0006418)2.72874383
118viral mRNA export from host cell nucleus (GO:0046784)2.72640990
119protein localization to mitochondrion (GO:0070585)2.72516128
120cytochrome complex assembly (GO:0017004)2.72238615
121respiratory chain complex IV assembly (GO:0008535)2.71926974
122cellular component biogenesis (GO:0044085)2.71643048
123SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.71212096
124viral transcription (GO:0019083)2.70510576
125regulation of cholesterol storage (GO:0010885)2.70380367
126spliceosomal snRNP assembly (GO:0000387)2.70327473
127amino acid activation (GO:0043038)2.69938055
128tRNA aminoacylation (GO:0043039)2.69938055
129nucleotide-excision repair, DNA gap filling (GO:0006297)2.69865721
130translation (GO:0006412)2.69836163
131monocarboxylic acid catabolic process (GO:0072329)2.68021177
132ribosomal small subunit assembly (GO:0000028)2.67645175
133tetrahydrofolate metabolic process (GO:0046653)2.66427269
134nucleobase biosynthetic process (GO:0046112)2.66148126
135short-chain fatty acid metabolic process (GO:0046459)2.61422765
136intestinal cholesterol absorption (GO:0030299)2.59700637
137alpha-linolenic acid metabolic process (GO:0036109)2.53101750
138L-serine metabolic process (GO:0006563)2.51595720
139negative regulation of fatty acid biosynthetic process (GO:0045717)2.50319714
140kynurenine metabolic process (GO:0070189)2.49188682
141aspartate family amino acid metabolic process (GO:0009066)2.48786249
142* carboxylic acid catabolic process (GO:0046395)2.48496558
143* organic acid catabolic process (GO:0016054)2.48496558
144positive regulation of lipid storage (GO:0010884)2.48360001
145regulation of triglyceride catabolic process (GO:0010896)2.47581283
1464-hydroxyproline metabolic process (GO:0019471)2.46553783
147pteridine-containing compound biosynthetic process (GO:0042559)2.45431417
148IMP metabolic process (GO:0046040)2.42958919
149sulfur amino acid biosynthetic process (GO:0000097)2.42883077
150regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.42098043
151folic acid-containing compound metabolic process (GO:0006760)2.41653949
152glucose catabolic process (GO:0006007)2.41241640
153* cellular amino acid catabolic process (GO:0009063)2.41132833
154triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.40240258
155lipid particle organization (GO:0034389)2.40070431
156carnitine transmembrane transport (GO:1902603)2.39735907
157brown fat cell differentiation (GO:0050873)2.39327555
158* alpha-amino acid catabolic process (GO:1901606)2.38359000
159L-phenylalanine catabolic process (GO:0006559)2.37989266
160erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.37989266
161carnitine transport (GO:0015879)2.36889346
162amino-acid betaine transport (GO:0015838)2.36889346
163xenobiotic catabolic process (GO:0042178)2.32951917
164aromatic amino acid family catabolic process (GO:0009074)2.32506165
165pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.32011952
166cellular modified amino acid catabolic process (GO:0042219)2.31997086
167one-carbon metabolic process (GO:0006730)2.31982801
168DNA strand elongation involved in DNA replication (GO:0006271)2.31663751
169indole-containing compound catabolic process (GO:0042436)2.31119907
170indolalkylamine catabolic process (GO:0046218)2.31119907
171tryptophan catabolic process (GO:0006569)2.31119907
172purine nucleobase biosynthetic process (GO:0009113)2.29101268
173complement activation, alternative pathway (GO:0006957)2.28551727
174AMP metabolic process (GO:0046033)2.28055326
175regulation of fatty acid oxidation (GO:0046320)2.25343484
176sulfur amino acid metabolic process (GO:0000096)2.23577334
177fatty acid homeostasis (GO:0055089)2.23537210
178pteridine-containing compound metabolic process (GO:0042558)2.22614178
179telomere maintenance via semi-conservative replication (GO:0032201)2.22589956
180nucleotide salvage (GO:0043173)2.21754838
181NADP metabolic process (GO:0006739)2.21469287
182tryptophan metabolic process (GO:0006568)2.21092962
183plasma lipoprotein particle clearance (GO:0034381)2.20743929
184triglyceride catabolic process (GO:0019433)2.20176217

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.76745598
2E2F7_22180533_ChIP-Seq_HELA_Human4.41909643
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.48513129
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.20532456
5MYC_18555785_ChIP-Seq_MESCs_Mouse2.89493823
6TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.56478473
7* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.38630482
8* RXR_22158963_ChIP-Seq_LIVER_Mouse2.31792081
9MYC_18358816_ChIP-ChIP_MESCs_Mouse2.15827033
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.09024548
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.08314139
12CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.03505123
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.02867390
14MYC_19079543_ChIP-ChIP_MESCs_Mouse1.98344078
15STAT3_1855785_ChIP-Seq_MESCs_Mouse1.95823697
16MYC_19030024_ChIP-ChIP_MESCs_Mouse1.92954365
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.90694479
18* ETS1_20019798_ChIP-Seq_JURKAT_Human1.81560968
19CREB1_15753290_ChIP-ChIP_HEK293T_Human1.79764642
20EST1_17652178_ChIP-ChIP_JURKAT_Human1.79495640
21POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.72680838
22E2F1_18555785_ChIP-Seq_MESCs_Mouse1.72647644
23CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.66959735
24NELFA_20434984_ChIP-Seq_ESCs_Mouse1.65719966
25ELF1_17652178_ChIP-ChIP_JURKAT_Human1.65582513
26FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.62697530
27* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.62425146
28TTF2_22483619_ChIP-Seq_HELA_Human1.60846519
29LXR_22158963_ChIP-Seq_LIVER_Mouse1.60760094
30CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.60483132
31GABP_17652178_ChIP-ChIP_JURKAT_Human1.59132266
32IRF8_22096565_ChIP-ChIP_GC-B_Human1.56380864
33TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53414380
34TET1_21451524_ChIP-Seq_MESCs_Mouse1.53029851
35FOXM1_23109430_ChIP-Seq_U2OS_Human1.52865042
36SRF_21415370_ChIP-Seq_HL-1_Mouse1.50762813
37* LXR_22292898_ChIP-Seq_THP-1_Human1.50266957
38* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.49852435
39NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.48209409
40E2F4_17652178_ChIP-ChIP_JURKAT_Human1.44960194
41DCP1A_22483619_ChIP-Seq_HELA_Human1.44721168
42ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.44475884
43SRY_22984422_ChIP-ChIP_TESTIS_Rat1.44374041
44FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.41489505
45XRN2_22483619_ChIP-Seq_HELA_Human1.40423288
46SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.38171141
47STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.38155341
48DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.36030046
49* RACK7_27058665_Chip-Seq_MCF-7_Human1.35818919
50CTCF_18555785_ChIP-Seq_MESCs_Mouse1.35154873
51* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.34087998
52CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.33021874
53* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.31578911
54SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.30651201
55SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.30459250
56MYC_22102868_ChIP-Seq_BL_Human1.30360110
57P68_20966046_ChIP-Seq_HELA_Human1.30141687
58CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.29158452
59TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.28798270
60HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.28670495
61ESR1_15608294_ChIP-ChIP_MCF-7_Human1.27649182
62YY1_21170310_ChIP-Seq_MESCs_Mouse1.27399601
63HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.27281590
64* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.26398513
65VDR_23849224_ChIP-Seq_CD4+_Human1.26217402
66GABP_19822575_ChIP-Seq_HepG2_Human1.25465172
67FOXP1_21924763_ChIP-Seq_HESCs_Human1.24845056
68FOXP3_21729870_ChIP-Seq_TREG_Human1.24553471
69AR_21909140_ChIP-Seq_LNCAP_Human1.23373068
70ELF1_20517297_ChIP-Seq_JURKAT_Human1.22248275
71CLOCK_20551151_ChIP-Seq_293T_Human1.21477901
72VDR_21846776_ChIP-Seq_THP-1_Human1.21141807
73* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.20953697
74E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.19732338
75CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.19655023
76CIITA_25753668_ChIP-Seq_RAJI_Human1.19094219
77ELK3_25401928_ChIP-Seq_HUVEC_Human1.19039761
78FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.19022584
79* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.17714863
80ZFX_18555785_ChIP-Seq_MESCs_Mouse1.17128795
81POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.17059165
82PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15927851
83TBX5_21415370_ChIP-Seq_HL-1_Mouse1.15537955
84* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.10156799
85STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.10116131
86CTCF_26484167_Chip-Seq_Bcells_Mouse1.08053640
87ZNF263_19887448_ChIP-Seq_K562_Human1.07921730
88TFEB_21752829_ChIP-Seq_HELA_Human1.07380709
89TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.07310638
90E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07293385
91SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.07149300
92EGR1_19374776_ChIP-ChIP_THP-1_Human1.06917498
93SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.06317786
94* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.05447801
95IRF8_21731497_ChIP-ChIP_J774_Mouse1.05337734
96CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.05233991
97BP1_19119308_ChIP-ChIP_Hs578T_Human1.03960124
98* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.03668960
99YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03028250
100KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.03009974
101KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.03009974
102KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.03009974
103* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.01622166
104ATF3_27146783_Chip-Seq_COLON_Human1.01553791
105SA1_27219007_Chip-Seq_ERYTHROID_Human1.01117683
106BCOR_27268052_Chip-Seq_Bcells_Human1.01035387
107KDM5A_27292631_Chip-Seq_BREAST_Human1.00625174
108* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.00533566
109CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.00454641
110E2F1_21310950_ChIP-Seq_MCF-7_Human1.00306725
111THAP11_20581084_ChIP-Seq_MESCs_Mouse1.00302258
112RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.98831172
113ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.98431562
114RARG_19884340_ChIP-ChIP_MEFs_Mouse0.98313100
115* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.98235307
116* SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.98139822
117TCF3_18692474_ChIP-Seq_MEFs_Mouse0.97112622
118PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.96554329
119* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.95312434
120* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.95170165
121HOXB4_20404135_ChIP-ChIP_EML_Mouse0.93434496
122NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.93017133
123MYB_21317192_ChIP-Seq_ERMYB_Mouse0.92725436
124IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.91846974
125* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.91247218
126NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.90967666
127* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.90551416
128SPI1_23547873_ChIP-Seq_NB4_Human0.90033989
129FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.86845571
130HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.86812998
131DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.86325853

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis3.61529774
2MP0005670_abnormal_white_adipose3.36464235
3MP0005365_abnormal_bile_salt2.97682339
4MP0002139_abnormal_hepatobiliary_system2.81177059
5MP0010030_abnormal_orbit_morphology2.55879300
6MP0003186_abnormal_redox_activity2.49835643
7MP0008932_abnormal_embryonic_tissue2.31158773
8MP0005360_urolithiasis2.30910036
9MP0003646_muscle_fatigue2.25058859
10MP0005085_abnormal_gallbladder_physiolo2.23421416
11MP0000678_abnormal_parathyroid_gland2.18906379
12MP0005666_abnormal_adipose_tissue2.17082197
13MP0005083_abnormal_biliary_tract2.15121566
14MP0001666_abnormal_nutrient_absorption2.05665379
15MP0004130_abnormal_muscle_cell2.04269677
16MP0002837_dystrophic_cardiac_calcinosis1.97128472
17MP0002163_abnormal_gland_morphology1.94488201
18MP0009697_abnormal_copulation1.93948875
19MP0010234_abnormal_vibrissa_follicle1.92552927
20MP0006036_abnormal_mitochondrial_physio1.86663071
21MP0004185_abnormal_adipocyte_glucose1.83036883
22MP0003693_abnormal_embryo_hatching1.82963037
23MP0003705_abnormal_hypodermis_morpholog1.77982372
24MP0010329_abnormal_lipoprotein_level1.72603431
25* MP0005332_abnormal_amino_acid1.71215489
26MP0000003_abnormal_adipose_tissue1.65802171
27MP0005501_abnormal_skin_physiology1.59220805
28MP0003191_abnormal_cellular_cholesterol1.58476822
29MP0001730_embryonic_growth_arrest1.55449012
30MP0001853_heart_inflammation1.53520990
31MP0005319_abnormal_enzyme/_coenzyme1.52892472
32MP0004084_abnormal_cardiac_muscle1.47737393
33MP0003123_paternal_imprinting1.46699944
34MP0004233_abnormal_muscle_weight1.46173987
35MP0000537_abnormal_urethra_morphology1.45245257
36MP0005367_renal/urinary_system_phenotyp1.45013542
37MP0000516_abnormal_urinary_system1.45013542
38MP0009840_abnormal_foam_cell1.43711538
39MP0002249_abnormal_larynx_morphology1.43584871
40MP0003221_abnormal_cardiomyocyte_apopto1.41270186
41MP0000609_abnormal_liver_physiology1.40995323
42MP0003718_maternal_effect1.39966917
43MP0004957_abnormal_blastocyst_morpholog1.38530739
44MP0000750_abnormal_muscle_regeneration1.36855614
45MP0005330_cardiomyopathy1.35986827
46MP0008007_abnormal_cellular_replicative1.35898246
47* MP0009643_abnormal_urine_homeostasis1.32746284
48MP0001727_abnormal_embryo_implantation1.32365912
49MP0003315_abnormal_perineum_morphology1.31612853
50MP0000350_abnormal_cell_proliferation1.31005703
51MP0008438_abnormal_cutaneous_collagen1.28934018
52MP0003111_abnormal_nucleus_morphology1.27725438
53MP0002796_impaired_skin_barrier1.25819412
54MP0010352_gastrointestinal_tract_polyps1.25252355
55MP0005375_adipose_tissue_phenotype1.25016082
56MP0008875_abnormal_xenobiotic_pharmacok1.24711466
57* MP0002118_abnormal_lipid_homeostasis1.23329589
58MP0008995_early_reproductive_senescence1.20197610
59MP0001881_abnormal_mammary_gland1.19662301
60MP0003195_calcinosis1.19439249
61MP0000747_muscle_weakness1.18285095
62MP0002234_abnormal_pharynx_morphology1.18175913
63MP0000313_abnormal_cell_death1.17471462
64MP0001849_ear_inflammation1.17412327
65MP0002269_muscular_atrophy1.16885129
66MP0003077_abnormal_cell_cycle1.16436877
67MP0002080_prenatal_lethality1.16198171
68MP0001697_abnormal_embryo_size1.16079629
69MP0005075_abnormal_melanosome_morpholog1.12465581
70MP0003283_abnormal_digestive_organ1.12281209
71MP0001835_abnormal_antigen_presentation1.10075928
72MP0010094_abnormal_chromosome_stability1.09312475
73MP0002396_abnormal_hematopoietic_system1.08588666
74MP0006035_abnormal_mitochondrial_morpho1.08405159
75MP0001944_abnormal_pancreas_morphology1.08296122
76MP0002138_abnormal_hepatobiliary_system1.08067822
77MP0000343_altered_response_to1.07649368
78MP0000598_abnormal_liver_morphology1.05447179
79MP0003566_abnormal_cell_adhesion1.04533681
80MP0005397_hematopoietic_system_phenotyp1.04329324
81MP0001545_abnormal_hematopoietic_system1.04329324
82MP0005380_embryogenesis_phenotype1.03586779
83MP0001672_abnormal_embryogenesis/_devel1.03586779
84* MP0001764_abnormal_homeostasis1.02825686
85MP0004087_abnormal_muscle_fiber1.02676108
86MP0005266_abnormal_metabolism1.02545072
87MP0005451_abnormal_body_composition1.02400925
88MP0009115_abnormal_fat_cell1.02016953
89MP0001544_abnormal_cardiovascular_syste1.02013584
90MP0005385_cardiovascular_system_phenoty1.02013584
91MP0003252_abnormal_bile_duct1.01572022
92MP0010630_abnormal_cardiac_muscle1.01043372
93MP0005220_abnormal_exocrine_pancreas1.00292792
94MP0001661_extended_life_span1.00085755
95MP0000749_muscle_degeneration1.00005426
96MP0003436_decreased_susceptibility_to0.99778773
97MP0002971_abnormal_brown_adipose0.99754914
98MP0000538_abnormal_urinary_bladder0.99584635
99MP0000490_abnormal_crypts_of0.99422465
100MP0005645_abnormal_hypothalamus_physiol0.98579922
101MP0002254_reproductive_system_inflammat0.98528711
102MP0008775_abnormal_heart_ventricle0.97387962
103MP0000462_abnormal_digestive_system0.96036931
104MP0004019_abnormal_vitamin_homeostasis0.95981217
105MP0001873_stomach_inflammation0.95784090
106MP0002970_abnormal_white_adipose0.95620665
107MP0005058_abnormal_lysosome_morphology0.95336304
108MP0003828_pulmonary_edema0.95062348
109MP0005584_abnormal_enzyme/coenzyme_acti0.94390996
110MP0009672_abnormal_birth_weight0.94125094
111MP0003942_abnormal_urinary_system0.94118422
112MP0003656_abnormal_erythrocyte_physiolo0.93589318
113MP0002088_abnormal_embryonic_growth/wei0.92620899
114MP0002132_abnormal_respiratory_system0.92522732
115MP0008057_abnormal_DNA_replication0.90663163
116MP0001529_abnormal_vocalization0.90428905
117MP0003567_abnormal_fetal_cardiomyocyte0.89587238
118MP0008469_abnormal_protein_level0.88649705
119MP0000858_altered_metastatic_potential0.87273146
120MP0000685_abnormal_immune_system0.86647225
121MP0005636_abnormal_mineral_homeostasis0.86562013
122MP0004036_abnormal_muscle_relaxation0.85541390
123MP0002877_abnormal_melanocyte_morpholog0.85538456
124MP0005379_endocrine/exocrine_gland_phen0.85152614
125MP0002938_white_spotting0.82301445
126MP0009333_abnormal_splenocyte_physiolog0.81309531
127MP0003724_increased_susceptibility_to0.80694354
128* MP0005334_abnormal_fat_pad0.80672734
129MP0009763_increased_sensitivity_to0.80333022
130MP0008260_abnormal_autophagy0.78931456
131MP0002085_abnormal_embryonic_tissue0.77941988
132MP0000759_abnormal_skeletal_muscle0.77637316
133MP0002019_abnormal_tumor_incidence0.76431677
134MP0000751_myopathy0.75941569
135MP0000372_irregular_coat_pigmentation0.75818801
136MP0008058_abnormal_DNA_repair0.75070045
137MP0009785_altered_susceptibility_to0.73659634
138MP0006138_congestive_heart_failure0.73062853
139MP0002972_abnormal_cardiac_muscle0.73035155
140MP0000013_abnormal_adipose_tissue0.72539373
141MP0009379_abnormal_foot_pigmentation0.72235796
142* MP0001756_abnormal_urination0.72124911
143MP0005025_abnormal_response_to0.71858173
144MP0003763_abnormal_thymus_physiology0.71728422
145MP0004147_increased_porphyrin_level0.71568645
146MP0002060_abnormal_skin_morphology0.71002143
147MP0003786_premature_aging0.70822388
148MP0005647_abnormal_sex_gland0.70572740
149MP0003984_embryonic_growth_retardation0.69640960
150MP0004145_abnormal_muscle_electrophysio0.69378425
151* MP0002136_abnormal_kidney_physiology0.69247899
152MP0001845_abnormal_inflammatory_respons0.69195232
153MP0000358_abnormal_cell_content/0.68712934

Predicted human phenotypes

RankGene SetZ-score
1Hyperglycinuria (HP:0003108)4.73972111
2Abnormality of glycine metabolism (HP:0010895)3.92509016
3Abnormality of serine family amino acid metabolism (HP:0010894)3.92509016
4Abnormality of fatty-acid metabolism (HP:0004359)3.91311933
5Nausea (HP:0002018)3.86966536
6Abnormal mitochondria in muscle tissue (HP:0008316)3.80261827
7Dicarboxylic aciduria (HP:0003215)3.72039899
8Abnormality of dicarboxylic acid metabolism (HP:0010995)3.72039899
9Hyperammonemia (HP:0001987)3.68482146
10Myoglobinuria (HP:0002913)3.68445121
11Rhabdomyolysis (HP:0003201)3.66880933
12Abnormal gallbladder physiology (HP:0012438)3.62448709
13Cholecystitis (HP:0001082)3.62448709
14Hypoglycemic coma (HP:0001325)3.60270379
15Multiple enchondromatosis (HP:0005701)3.41988858
16Acute necrotizing encephalopathy (HP:0006965)3.37422533
17Mitochondrial inheritance (HP:0001427)3.36811788
18Ketosis (HP:0001946)3.31872237
19Hyperglycinemia (HP:0002154)3.30416195
20Increased CSF lactate (HP:0002490)3.14375165
21Septate vagina (HP:0001153)3.02815965
22Ketoacidosis (HP:0001993)3.01603408
23Generalized aminoaciduria (HP:0002909)3.00379158
24Abnormality of pyrimidine metabolism (HP:0004353)2.94126980
25Aplasia/Hypoplasia of the sacrum (HP:0008517)2.86980403
26Hepatic necrosis (HP:0002605)2.84994163
27Increased intramyocellular lipid droplets (HP:0012240)2.83383144
28Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.73948134
29Type I transferrin isoform profile (HP:0003642)2.69950206
30Microretrognathia (HP:0000308)2.68386018
31Abnormality of monocarboxylic acid metabolism (HP:0010996)2.67942187
32Truncus arteriosus (HP:0001660)2.67185331
33Ventricular tachycardia (HP:0004756)2.65866652
34Cerebral edema (HP:0002181)2.62084861
35Progressive macrocephaly (HP:0004481)2.59938515
36Lethargy (HP:0001254)2.59217675
37Increased muscle lipid content (HP:0009058)2.58414639
38Hypokinesia (HP:0002375)2.56007135
39Increased connective tissue (HP:0009025)2.55496012
40Hyperthyroidism (HP:0000836)2.53895612
41Proximal tubulopathy (HP:0000114)2.50736512
42Abnormality of serum amino acid levels (HP:0003112)2.47182422
43Hypertriglyceridemia (HP:0002155)2.46596356
44Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.39835019
45Abnormal protein N-linked glycosylation (HP:0012347)2.39835019
46Abnormal protein glycosylation (HP:0012346)2.39835019
47Abnormal glycosylation (HP:0012345)2.39835019
48Hyperinsulinemic hypoglycemia (HP:0000825)2.38105744
49Progressive muscle weakness (HP:0003323)2.37249549
50Abnormality of nucleobase metabolism (HP:0010932)2.36605759
51Respiratory failure (HP:0002878)2.36352308
52Pancreatitis (HP:0001733)2.33206882
53Abnormality of aromatic amino acid family metabolism (HP:0004338)2.32326298
54Xanthomatosis (HP:0000991)2.31645013
55Metabolic acidosis (HP:0001942)2.31169617
56Myopathic facies (HP:0002058)2.30818891
57Exercise-induced muscle cramps (HP:0003710)2.30785963
58Abnormality of sulfur amino acid metabolism (HP:0004339)2.30173440
59Hypoplastic left heart (HP:0004383)2.29846195
60Lipoatrophy (HP:0100578)2.29470558
61Hypoalphalipoproteinemia (HP:0003233)2.29450437
62Rough bone trabeculation (HP:0100670)2.29025163
63Palpitations (HP:0001962)2.27515037
64Stridor (HP:0010307)2.26937218
65Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.23693380
66Decreased activity of mitochondrial respiratory chain (HP:0008972)2.21222768
67Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.21222768
68Trismus (HP:0000211)2.20721422
69Abnormal gallbladder morphology (HP:0012437)2.18622512
70Right ventricular cardiomyopathy (HP:0011663)2.17649686
71Vomiting (HP:0002013)2.17007487
72Renal cortical cysts (HP:0000803)2.16561183
73Hyperlipoproteinemia (HP:0010980)2.16479304
74Gout (HP:0001997)2.16059646
75Lactic acidosis (HP:0003128)2.15799392
76Cholelithiasis (HP:0001081)2.15554167
77Intrahepatic cholestasis (HP:0001406)2.14805376
78Abnormality of aspartate family amino acid metabolism (HP:0010899)2.11065104
79Abnormality of the anterior horn cell (HP:0006802)2.11054178
80Degeneration of anterior horn cells (HP:0002398)2.11054178
81Abnormality of glutamine family amino acid metabolism (HP:0010902)2.10712921
82Abnormality of cells of the erythroid lineage (HP:0012130)2.10643810
83Congenital malformation of the right heart (HP:0011723)2.10193280
84Double outlet right ventricle (HP:0001719)2.10193280
85Abnormal cartilage morphology (HP:0002763)2.09848188
86Unilateral renal agenesis (HP:0000122)2.09138109
87Hypoglycemic seizures (HP:0002173)2.08257350
88Prolonged neonatal jaundice (HP:0006579)2.08216102
89Abnormality of purine metabolism (HP:0004352)2.07845149
903-Methylglutaconic aciduria (HP:0003535)2.07815345
91Abnormal number of erythroid precursors (HP:0012131)2.06799956
92Increased purine levels (HP:0004368)2.06716342
93Hyperuricemia (HP:0002149)2.06716342
94Secondary amenorrhea (HP:0000869)2.06058467
95Abnormality of glycolysis (HP:0004366)2.05677119
96Increased serum pyruvate (HP:0003542)2.05677119
97Complement deficiency (HP:0004431)2.04144469
98Villous atrophy (HP:0011473)2.03338287
99Abnormality of small intestinal villus morphology (HP:0011472)2.03338287
100Renal Fanconi syndrome (HP:0001994)2.02599563
101Abnormality of the gallbladder (HP:0005264)2.00772788
102Abnormality of methionine metabolism (HP:0010901)2.00769676
103Centrally nucleated skeletal muscle fibers (HP:0003687)2.00032645
104Abnormality of the umbilical cord (HP:0010881)1.99208744
105Long foot (HP:0001833)1.98620202
106Myocardial infarction (HP:0001658)1.98130860
107Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.97699696
108Testicular atrophy (HP:0000029)1.97515538
109Hepatocellular necrosis (HP:0001404)1.96307893
110Abnormal trabecular bone morphology (HP:0100671)1.96098752
111Increased hepatocellular lipid droplets (HP:0006565)1.95932730
112Dilated cardiomyopathy (HP:0001644)1.95175214
113Hypergonadotropic hypogonadism (HP:0000815)1.95151449
114Acute encephalopathy (HP:0006846)1.94844914
115Lipid accumulation in hepatocytes (HP:0006561)1.93730577
116Reduced antithrombin III activity (HP:0001976)1.93325081
117Increased serum lactate (HP:0002151)1.92623323
118Hypolipoproteinemia (HP:0010981)1.91295226
119Redundant skin (HP:0001582)1.88441777
120Increased serum ferritin (HP:0003281)1.86587243
121Reticulocytopenia (HP:0001896)1.84503284
122Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.83931152
123Delayed CNS myelination (HP:0002188)1.83721999
124Exercise-induced myalgia (HP:0003738)1.83474286
125Steatorrhea (HP:0002570)1.83422057
126Prominent metopic ridge (HP:0005487)1.83046065
127Generalized amyotrophy (HP:0003700)1.80103449
128Abnormality of transition element cation homeostasis (HP:0011030)1.79886890
129Distal lower limb muscle weakness (HP:0009053)1.79741109
130Prenatal maternal abnormality (HP:0002686)1.79583790
131Methylmalonic aciduria (HP:0012120)1.78474611
132Hypoplastic heart (HP:0001961)1.77966383
133Muscle fiber splitting (HP:0003555)1.77081340
134Exercise intolerance (HP:0003546)1.76881542
135Acute hepatic failure (HP:0006554)1.76500479
136Hydroxyprolinuria (HP:0003080)1.76434448
137Abnormality of proline metabolism (HP:0010907)1.76434448
138Abnormality of complement system (HP:0005339)1.76212954
139Opisthotonus (HP:0002179)1.75332024
140Ragged-red muscle fibers (HP:0003200)1.75021537
141Epidermoid cyst (HP:0200040)1.73873730
142Achilles tendon contracture (HP:0001771)1.73771432
143Petechiae (HP:0000967)1.72978070
144Microvesicular hepatic steatosis (HP:0001414)1.72334183
145Asymmetric septal hypertrophy (HP:0001670)1.71785293
146Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.71720697
147Abnormality of alanine metabolism (HP:0010916)1.71720697
148Hyperalaninemia (HP:0003348)1.71720697
149Macrocytic anemia (HP:0001972)1.71597209
150Abnormality of reticulocytes (HP:0004312)1.71393013
151Seborrheic dermatitis (HP:0001051)1.71057254
152J-shaped sella turcica (HP:0002680)1.70954128
153Oligomenorrhea (HP:0000876)1.70791513
154Systemic lupus erythematosus (HP:0002725)1.69661592
155Abnormalities of placenta or umbilical cord (HP:0001194)1.69453020
156Sparse eyelashes (HP:0000653)1.69399616
157Squamous cell carcinoma (HP:0002860)1.68861738
158Symptomatic seizures (HP:0011145)1.68813128
159Abnormality of the Achilles tendon (HP:0005109)1.68665563
160Abnormality of iron homeostasis (HP:0011031)1.68333168
161Fat malabsorption (HP:0002630)1.67400467
162Insulin resistance (HP:0000855)1.66129484
163Abnormality of the intrinsic pathway (HP:0010989)1.65434645
164Metaphyseal cupping (HP:0003021)1.63125538
165Neoplasm of head and neck (HP:0012288)1.63051540

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.01877718
2VRK24.53860641
3SMG13.37018166
4TRIB33.19656085
5PKN23.09884263
6ERN12.82215759
7FLT32.46483377
8NME22.40374649
9ARAF2.36410252
10TESK12.22541259
11IRAK32.18507044
12PDK32.18393560
13PDK42.18393560
14NEK12.06481132
15TTN2.01345938
16EIF2AK11.99652302
17TESK21.97972836
18BUB11.91646926
19VRK11.84675976
20MAP2K31.73316759
21MAPKAPK31.64166194
22EIF2AK31.63639502
23PDK21.61810894
24NME11.61578694
25WEE11.45742403
26SIK11.45091085
27KDR1.42892407
28RPS6KB21.37957369
29TYK21.33963016
30LIMK11.30420846
31MAP4K11.29739859
32AURKA1.28285433
33MYLK1.27046037
34CDK81.26666913
35STK41.25745087
36DAPK11.24011388
37PINK11.19152989
38JAK31.17935971
39EEF2K1.14973007
40ICK1.13642991
41CDK41.12624882
42TLK11.11375325
43MST1R1.10038600
44PIM21.08850785
45SCYL21.08539518
46CDK71.08377125
47FGFR41.06911521
48LMTK21.05380672
49MAP3K111.05329041
50PRKCI1.04482173
51ZAP701.01619337
52STK38L1.00236301
53BRSK11.00077052
54CSNK1G30.99577655
55BRAF0.98961452
56TBK10.98670998
57LRRK20.98552198
58MAP3K30.97474255
59TTK0.97363426
60RPS6KA50.95337291
61CHEK20.92014481
62PIM10.91263555
63PRKD30.87367595
64MAPK110.87333766
65EPHA20.82707030
66ZAK0.81518891
67MAP3K80.81372379
68STK100.79533688
69IRAK40.79180431
70NEK90.78424075
71PAK40.78244982
72TAF10.78227571
73TIE10.78166927
74MST40.77946793
75NEK20.77626466
76CSNK1G10.76622105
77CAMK1D0.76443992
78CDK120.76211295
79OBSCN0.76073611
80MAP3K140.75859623
81IKBKB0.74196789
82PASK0.73800932
83RPS6KA40.73644523
84ATR0.73196830
85MUSK0.71291738
86BLK0.70662048
87PLK10.68018050
88AURKB0.66127515
89CSNK1A1L0.65479117
90NUAK10.65442013
91RIPK10.65147231
92MAP3K120.65019375
93ABL20.64191436
94TAOK20.62547804
95TGFBR10.62183385
96STK160.60464935
97MAP3K100.58991315
98CDK60.58699979
99ILK0.58656745
100BTK0.58270147
101TGFBR20.57924535
102CDC70.57244182
103CHEK10.56293509
104MTOR0.55210808
105PAK10.53136720
106MAPKAPK50.51565670
107TSSK60.49998943
108RAF10.49842697
109PHKG10.49359860
110PHKG20.49359860
111MAP2K20.48985552
112MAP3K10.48861161
113CHUK0.48710442
114PTK60.47870588
115LATS10.47700454
116EIF2AK20.47600690
117MAP4K20.47160478
118JAK20.46987692
119PRKAA20.46467996
120CAMK2G0.46428952
121FER0.46108945
122PBK0.45950300
123PLK30.45515553
124DAPK30.44873654
125PTK20.43170872
126AKT20.42423031
127CSNK2A20.42089134
128KIT0.41643000
129MAPK120.41613268
130RPS6KA60.41393297
131SRPK10.41173839
132IKBKE0.40908879
133HIPK20.40679118
134EPHB10.40570104
135PLK40.39472379
136IRAK20.39391380
137CSF1R0.39370279
138MAP3K50.39311571
139PIK3CG0.39228200
140CDK90.37222779
141PRKAA10.36891685
142MAP2K60.36520476
143CSNK2A10.36492337
144RPS6KL10.36452364
145RPS6KC10.36452364
146PRPF4B0.35444061
147BMX0.30905501

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.06656843
2Propanoate metabolism_Homo sapiens_hsa006403.00501953
3* 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.97819252
4* Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.81279321
5Fatty acid degradation_Homo sapiens_hsa000712.58339881
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.31041710
7Carbon metabolism_Homo sapiens_hsa012002.17109800
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.11836399
9One carbon pool by folate_Homo sapiens_hsa006702.04995506
10Fatty acid metabolism_Homo sapiens_hsa012121.93792682
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.92998747
12DNA replication_Homo sapiens_hsa030301.88627350
13* Biosynthesis of amino acids_Homo sapiens_hsa012301.85100487
14beta-Alanine metabolism_Homo sapiens_hsa004101.76007103
15Pyruvate metabolism_Homo sapiens_hsa006201.73895661
16PPAR signaling pathway_Homo sapiens_hsa033201.67163766
17Folate biosynthesis_Homo sapiens_hsa007901.65256086
18Sulfur metabolism_Homo sapiens_hsa009201.63660521
19Tryptophan metabolism_Homo sapiens_hsa003801.61597782
20Peroxisome_Homo sapiens_hsa041461.60577329
21Mismatch repair_Homo sapiens_hsa034301.53947688
22Fat digestion and absorption_Homo sapiens_hsa049751.53005116
23Proteasome_Homo sapiens_hsa030501.51191942
24Ribosome_Homo sapiens_hsa030101.46145721
25Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.37555523
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.37422013
27Sulfur relay system_Homo sapiens_hsa041221.33297170
28Selenocompound metabolism_Homo sapiens_hsa004501.31985814
29Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.30987724
30Pentose phosphate pathway_Homo sapiens_hsa000301.30431514
31* Cysteine and methionine metabolism_Homo sapiens_hsa002701.30247112
32Arginine biosynthesis_Homo sapiens_hsa002201.29708910
33Drug metabolism - other enzymes_Homo sapiens_hsa009831.29679418
34Primary bile acid biosynthesis_Homo sapiens_hsa001201.28782500
35Phenylalanine metabolism_Homo sapiens_hsa003601.27712589
36Pentose and glucuronate interconversions_Homo sapiens_hsa000401.24642653
37Base excision repair_Homo sapiens_hsa034101.24605601
38Alzheimers disease_Homo sapiens_hsa050101.19171822
39Maturity onset diabetes of the young_Homo sapiens_hsa049501.18522734
40Glycerolipid metabolism_Homo sapiens_hsa005611.16473420
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.13669898
42Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.12677561
43N-Glycan biosynthesis_Homo sapiens_hsa005101.12647207
44Cyanoamino acid metabolism_Homo sapiens_hsa004601.12479980
45Fructose and mannose metabolism_Homo sapiens_hsa000511.12053688
46RNA polymerase_Homo sapiens_hsa030201.10721127
47Pyrimidine metabolism_Homo sapiens_hsa002401.10295319
48Glutathione metabolism_Homo sapiens_hsa004801.07547607
49Arginine and proline metabolism_Homo sapiens_hsa003301.06974231
50Fatty acid biosynthesis_Homo sapiens_hsa000611.05009012
51* Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.99909768
52Starch and sucrose metabolism_Homo sapiens_hsa005000.98302925
53Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.98194107
54Caffeine metabolism_Homo sapiens_hsa002320.96610506
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.94856640
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.93737423
57Homologous recombination_Homo sapiens_hsa034400.93377467
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.93315609
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.92112697
60Non-homologous end-joining_Homo sapiens_hsa034500.91915280
61Butanoate metabolism_Homo sapiens_hsa006500.91091530
62Vibrio cholerae infection_Homo sapiens_hsa051100.90029246
63Tyrosine metabolism_Homo sapiens_hsa003500.86890883
64Staphylococcus aureus infection_Homo sapiens_hsa051500.84319484
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.84229722
66Chemical carcinogenesis_Homo sapiens_hsa052040.83337293
67Steroid biosynthesis_Homo sapiens_hsa001000.82728883
68Nucleotide excision repair_Homo sapiens_hsa034200.82185864
69Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.81721373
70Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.81585317
71Complement and coagulation cascades_Homo sapiens_hsa046100.81260239
72Lysine degradation_Homo sapiens_hsa003100.81075045
73Vitamin digestion and absorption_Homo sapiens_hsa049770.80745748
74Galactose metabolism_Homo sapiens_hsa000520.79951300
75Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.78770940
76Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.75665245
77Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.74704436
78RNA transport_Homo sapiens_hsa030130.74382748
79Systemic lupus erythematosus_Homo sapiens_hsa053220.72186647
80Histidine metabolism_Homo sapiens_hsa003400.71347552
81Fatty acid elongation_Homo sapiens_hsa000620.69422924
82Other glycan degradation_Homo sapiens_hsa005110.68080097
83Legionellosis_Homo sapiens_hsa051340.67843814
84Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.67072222
85Parkinsons disease_Homo sapiens_hsa050120.67059083
86Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.67043652
87* Metabolic pathways_Homo sapiens_hsa011000.63529828
88Spliceosome_Homo sapiens_hsa030400.61841180
89Oxidative phosphorylation_Homo sapiens_hsa001900.59432619
90Glycosaminoglycan degradation_Homo sapiens_hsa005310.57949849
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.55989194
92Protein digestion and absorption_Homo sapiens_hsa049740.50688601
93Nitrogen metabolism_Homo sapiens_hsa009100.50247277
94Central carbon metabolism in cancer_Homo sapiens_hsa052300.48393912
95Basal transcription factors_Homo sapiens_hsa030220.47044494
96Cardiac muscle contraction_Homo sapiens_hsa042600.45028530
97alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.44958645
98Retinol metabolism_Homo sapiens_hsa008300.43849319
99p53 signaling pathway_Homo sapiens_hsa041150.43720290
100Alcoholism_Homo sapiens_hsa050340.43524994
101Fanconi anemia pathway_Homo sapiens_hsa034600.40538485
102Insulin resistance_Homo sapiens_hsa049310.40322556
103RNA degradation_Homo sapiens_hsa030180.40280075
104Vitamin B6 metabolism_Homo sapiens_hsa007500.39178894
105Protein export_Homo sapiens_hsa030600.37554671
106Arachidonic acid metabolism_Homo sapiens_hsa005900.37530937
107Linoleic acid metabolism_Homo sapiens_hsa005910.37080270
108Herpes simplex infection_Homo sapiens_hsa051680.37006202
109Purine metabolism_Homo sapiens_hsa002300.36710179
110Huntingtons disease_Homo sapiens_hsa050160.36037303
111Cell cycle_Homo sapiens_hsa041100.35396987
112Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.34851008
113Renin-angiotensin system_Homo sapiens_hsa046140.32698568
114Viral myocarditis_Homo sapiens_hsa054160.32688452
115ABC transporters_Homo sapiens_hsa020100.32503611
116Glucagon signaling pathway_Homo sapiens_hsa049220.30874265
117Steroid hormone biosynthesis_Homo sapiens_hsa001400.30300638
118Collecting duct acid secretion_Homo sapiens_hsa049660.24808951
119Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.24184022
120AMPK signaling pathway_Homo sapiens_hsa041520.21638262
121mRNA surveillance pathway_Homo sapiens_hsa030150.18293924
122Bladder cancer_Homo sapiens_hsa052190.16197463
123Epstein-Barr virus infection_Homo sapiens_hsa051690.15060907
124Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.14332823

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