BCAM

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes Lutheran blood group glycoprotein, a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin. The protein contains five extracellular immunoglobulin domains, a single transmembrane domain, and a short C-terminal cytoplasmic tail. This protein may play a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease. Polymorphisms in this gene define some of the antigens in the Lutheran system and also the Auberger system. Inactivating variants of this gene result in the recessive Lutheran null phenotype, Lu(a-b-), of the Lutheran blood group. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1surfactant homeostasis (GO:0043129)6.66369225
2hemidesmosome assembly (GO:0031581)6.19104824
3bundle of His cell to Purkinje myocyte communication (GO:0086069)6.05877326
4chemical homeostasis within a tissue (GO:0048875)5.21404761
5sarcomere organization (GO:0045214)5.03563518
6negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.96428780
7plasma membrane repair (GO:0001778)4.82206853
8glomerular visceral epithelial cell development (GO:0072015)4.81358097
9cardiac myofibril assembly (GO:0055003)4.69755872
10desmosome organization (GO:0002934)4.50328036
11negative regulation of potassium ion transmembrane transport (GO:1901380)4.50259981
12glomerular epithelial cell development (GO:0072310)4.48567649
13epithelial cell-cell adhesion (GO:0090136)4.20325501
14renal filtration (GO:0097205)4.16347225
15glomerular basement membrane development (GO:0032836)4.14845925
16ventricular cardiac muscle cell action potential (GO:0086005)4.13911586
17vascular endothelial growth factor signaling pathway (GO:0038084)4.13574907
18regulation of cardioblast differentiation (GO:0051890)4.07497747
19thyroid hormone generation (GO:0006590)4.02777485
20myofibril assembly (GO:0030239)3.98260895
21regulation of cholesterol biosynthetic process (GO:0045540)3.95447665
22cell communication involved in cardiac conduction (GO:0086065)3.91616767
23cell-substrate junction assembly (GO:0007044)3.88730381
24semaphorin-plexin signaling pathway (GO:0071526)3.84845187
25regulation of hippo signaling (GO:0035330)3.79964394
26planar cell polarity pathway involved in neural tube closure (GO:0090179)3.74776264
27cardiac muscle cell development (GO:0055013)3.67586096
28positive regulation of hormone metabolic process (GO:0032352)3.65235641
29actomyosin structure organization (GO:0031032)3.60017435
30cardiac muscle contraction (GO:0060048)3.57845073
31muscle filament sliding (GO:0030049)3.57426785
32actin-myosin filament sliding (GO:0033275)3.57426785
33cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.55690189
34cardiac cell development (GO:0055006)3.55246088
35heart trabecula formation (GO:0060347)3.52126003
36peptidyl-tyrosine autophosphorylation (GO:0038083)3.50329097
37regulation of cholesterol homeostasis (GO:2000188)3.45696135
38ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.45508418
39cell-cell junction maintenance (GO:0045217)3.44058843
40regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.42676191
41Golgi transport vesicle coating (GO:0048200)3.41853038
42COPI coating of Golgi vesicle (GO:0048205)3.41853038
43biotin metabolic process (GO:0006768)3.40435655
44regulation of p38MAPK cascade (GO:1900744)3.40136075
45gap junction assembly (GO:0016264)3.35713499
46atrioventricular valve morphogenesis (GO:0003181)3.33700030
47branching involved in salivary gland morphogenesis (GO:0060445)3.33045817
48cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.32006382
49cytoskeletal anchoring at plasma membrane (GO:0007016)3.31026320
50cell migration involved in sprouting angiogenesis (GO:0002042)3.29948186
51coronary vasculature morphogenesis (GO:0060977)3.27957494
52insulin-like growth factor receptor signaling pathway (GO:0048009)3.26253338
53tricarboxylic acid cycle (GO:0006099)3.25432688
54establishment of apical/basal cell polarity (GO:0035089)3.24409066
55regulation of water loss via skin (GO:0033561)3.24401083
56lung epithelium development (GO:0060428)3.24173951
57glomerular filtration (GO:0003094)3.23227457
58regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.22825025
59negative regulation of cell size (GO:0045792)3.22118748
60cardiac muscle tissue morphogenesis (GO:0055008)3.21891170
61negative regulation of fatty acid transport (GO:2000192)3.19064776
62basement membrane organization (GO:0071711)3.16912887
63regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.16518379
64positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.12938963
65peptidyl-glutamic acid carboxylation (GO:0017187)3.12014108
66protein carboxylation (GO:0018214)3.12014108
67protein localization to endosome (GO:0036010)3.11587571
68epithelial cell differentiation involved in prostate gland development (GO:0060742)3.10717166
69actin-mediated cell contraction (GO:0070252)3.10514024
70regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.10009810
71regulation of endothelial cell differentiation (GO:0045601)3.08486459
72regulation of tight junction assembly (GO:2000810)3.07555098
73regulation of actin filament-based movement (GO:1903115)3.07498201
74lymphangiogenesis (GO:0001946)3.05980871
75branching involved in mammary gland duct morphogenesis (GO:0060444)3.05904444
76embryonic retina morphogenesis in camera-type eye (GO:0060059)3.05594426
77cell junction maintenance (GO:0034331)3.04535560
78endothelial tube morphogenesis (GO:0061154)3.03790175
79morphogenesis of an endothelium (GO:0003159)3.03790175
80endothelial cell chemotaxis (GO:0035767)3.02578073
81proline biosynthetic process (GO:0006561)3.02574146
82carnitine shuttle (GO:0006853)3.02224909
83protein retention in ER lumen (GO:0006621)3.00763264
84cell communication by electrical coupling (GO:0010644)3.00701299
85ear development (GO:0043583)2.99048995
86muscle tissue morphogenesis (GO:0060415)2.99034363
87thyroid hormone metabolic process (GO:0042403)2.98816052
88outflow tract septum morphogenesis (GO:0003148)2.95343474
89maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.94362790
90very-low-density lipoprotein particle assembly (GO:0034379)2.92800395
91positive regulation of p38MAPK cascade (GO:1900745)2.90851095
92regulation of fatty acid beta-oxidation (GO:0031998)2.90771039
93regulation of skeletal muscle contraction (GO:0014819)2.90478891
94positive regulation of cellular amine metabolic process (GO:0033240)2.90078351
95proline metabolic process (GO:0006560)2.89578547
96establishment of monopolar cell polarity (GO:0061162)2.89442220
97establishment or maintenance of monopolar cell polarity (GO:0061339)2.89442220
98positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.88277737
99membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.87967783
100negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.87718919
101response to parathyroid hormone (GO:0071107)2.86560881
102cardiac muscle cell action potential involved in contraction (GO:0086002)2.86473453
103polarized epithelial cell differentiation (GO:0030859)2.84860757
104regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.84475956
105adherens junction assembly (GO:0034333)2.84358042
106regulation of cholesterol metabolic process (GO:0090181)2.81844216
107venous blood vessel morphogenesis (GO:0048845)2.80341267
108regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.79873794
109fatty acid transmembrane transport (GO:1902001)2.77499465
110cardiac muscle cell action potential (GO:0086001)2.77084696
111retina vasculature morphogenesis in camera-type eye (GO:0061299)2.77017594
112multicellular organismal water homeostasis (GO:0050891)2.75280206
113establishment of skin barrier (GO:0061436)2.75014634
114phosphate ion homeostasis (GO:0055062)2.73758524
115trivalent inorganic anion homeostasis (GO:0072506)2.73758524
116regulation of apoptotic cell clearance (GO:2000425)2.73706476
117apoptotic process involved in morphogenesis (GO:0060561)2.73297770
118regulation of the force of heart contraction (GO:0002026)2.72905683
119membrane repolarization during action potential (GO:0086011)2.72753292
120cardiac right ventricle morphogenesis (GO:0003215)2.70432917
121regulation of endothelial cell chemotaxis (GO:2001026)2.70315291
122positive regulation of fatty acid beta-oxidation (GO:0032000)2.68714942
123actin filament-based movement (GO:0030048)2.67697522
124dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.67676331
125blood vessel endothelial cell migration (GO:0043534)2.67148750
126lymph vessel development (GO:0001945)2.66049377
127negative regulation of cell fate specification (GO:0009996)2.65260824
128cell-substrate adherens junction assembly (GO:0007045)2.63988078
129focal adhesion assembly (GO:0048041)2.63988078
130cell adhesion mediated by integrin (GO:0033627)2.63386263
131vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.62607528
132mesodermal cell differentiation (GO:0048333)2.62316304
133striated muscle contraction (GO:0006941)2.62113899
134negative regulation of cardiac muscle tissue growth (GO:0055022)2.61898412
135negative regulation of heart growth (GO:0061117)2.61898412
136exocrine pancreas development (GO:0031017)2.61663624
137retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.61127157
138endothelial cell morphogenesis (GO:0001886)2.60928902
139relaxation of cardiac muscle (GO:0055119)2.60924664
140intestinal epithelial cell development (GO:0060576)2.60800276
141Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.59907382
142regulation of glomerular filtration (GO:0003093)2.59323597
143stress fiber assembly (GO:0043149)2.59144108
144wound healing, spreading of epidermal cells (GO:0035313)2.59129006
145regulation of extracellular matrix disassembly (GO:0010715)2.56883269
146regulation of heart rate by cardiac conduction (GO:0086091)2.56065127
147apical protein localization (GO:0045176)2.55008906
148activation of Rac GTPase activity (GO:0032863)2.54246075
149plasma lipoprotein particle assembly (GO:0034377)2.53526146
150regulation of glucose import in response to insulin stimulus (GO:2001273)2.51178483
151regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.50322645
152regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.47779548
153negative regulation of cell fate commitment (GO:0010454)2.46500959
154renal system development (GO:0072001)2.46497592
155regulation of establishment of planar polarity (GO:0090175)2.45362506
156regulation of plasminogen activation (GO:0010755)2.45169156
157convergent extension (GO:0060026)2.44593993
158maternal placenta development (GO:0001893)2.43623583
159negative regulation of fibrinolysis (GO:0051918)2.40844502
160positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.39208097
161regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.38438359
162cellular zinc ion homeostasis (GO:0006882)2.37296077
163heart valve morphogenesis (GO:0003179)2.35038458
1644-hydroxyproline metabolic process (GO:0019471)2.34131274
165non-canonical Wnt signaling pathway (GO:0035567)2.33995737
166acetyl-CoA metabolic process (GO:0006084)2.32199057
167mammary gland epithelial cell differentiation (GO:0060644)2.31006118
168long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.30823452
169establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.29868083
170asymmetric protein localization (GO:0008105)2.29429877
171positive regulation of steroid biosynthetic process (GO:0010893)2.29000113
172water homeostasis (GO:0030104)2.28899735
173regulation of cell proliferation involved in kidney development (GO:1901722)2.28293431
174positive regulation of glycogen biosynthetic process (GO:0045725)2.27187816

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.78843845
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.81553208
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.34716364
4ZNF263_19887448_ChIP-Seq_K562_Human3.03377937
5TRIM28_21343339_ChIP-Seq_HEK293_Human3.02586159
6CLOCK_20551151_ChIP-Seq_293T_Human2.89747585
7* ESR2_21235772_ChIP-Seq_MCF-7_Human2.75533147
8ESR1_21235772_ChIP-Seq_MCF-7_Human2.55903040
9EP300_21415370_ChIP-Seq_HL-1_Mouse2.52264466
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.41951370
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.36145188
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.26810101
13NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.25548796
14ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.20482351
15TBX20_22080862_ChIP-Seq_HEART_Mouse2.16445147
16TBX20_22328084_ChIP-Seq_HEART_Mouse2.16445147
17TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.03431737
18SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.03010840
19RACK7_27058665_Chip-Seq_MCF-7_Human1.98651304
20PPARA_22158963_ChIP-Seq_LIVER_Mouse1.98251408
21ELK3_25401928_ChIP-Seq_HUVEC_Human1.96734661
22RXR_22158963_ChIP-Seq_LIVER_Mouse1.92029186
23STAT6_21828071_ChIP-Seq_BEAS2B_Human1.88392517
24* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.86965610
25TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.86389943
26KDM2B_26808549_Chip-Seq_SUP-B15_Human1.83459298
27TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.80509307
28EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.75278003
29* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.72330388
30HIF1A_21447827_ChIP-Seq_MCF-7_Human1.71857605
31ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.71577584
32* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.70717138
33* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.69865585
34FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.69001831
35LXR_22292898_ChIP-Seq_THP-1_Human1.66607619
36POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.66022408
37THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.64846161
38* ESR1_20079471_ChIP-ChIP_T-47D_Human1.63125985
39RUNX1_27514584_Chip-Seq_MCF-7_Human1.57806551
40GATA2_21666600_ChIP-Seq_HMVEC_Human1.57693044
41ESR1_15608294_ChIP-ChIP_MCF-7_Human1.57677345
42FOXO3_23340844_ChIP-Seq_DLD1_Human1.57224743
43* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.55583039
44SMC4_20622854_ChIP-Seq_HELA_Human1.54970434
45TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54075125
46RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.52073703
47KDM2B_26808549_Chip-Seq_K562_Human1.50321157
48ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.50074159
49CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.49781014
50ATF3_27146783_Chip-Seq_COLON_Human1.49014943
51TCF7_22412390_ChIP-Seq_EML_Mouse1.48728238
52PPAR_26484153_Chip-Seq_NCI-H1993_Human1.44434559
53* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.44319688
54* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.43935264
55* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.42743073
56CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.42584939
57ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.42437902
58* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.40767644
59FOXA2_19822575_ChIP-Seq_HepG2_Human1.40712973
60KDM2B_26808549_Chip-Seq_DND41_Human1.39043783
61TET1_21451524_ChIP-Seq_MESCs_Mouse1.37924766
62P300_27058665_Chip-Seq_ZR-75-30cells_Human1.36390822
63TCF3_18692474_ChIP-Seq_MEFs_Mouse1.35868303
64UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.35144966
65P63_26484246_Chip-Seq_KERATINOCYTES_Human1.33519237
66* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.32897826
67ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.31095797
68SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.29554223
69STAT3_1855785_ChIP-Seq_MESCs_Mouse1.29152362
70SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.28907792
71SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.28720193
72SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.28720193
73DNAJC2_21179169_ChIP-ChIP_NT2_Human1.27336427
74ZNF217_24962896_ChIP-Seq_MCF-7_Human1.26587339
75LXR_22158963_ChIP-Seq_LIVER_Mouse1.26467864
76KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.24523483
77KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.24523483
78KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.24523483
79CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.23968081
80NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.23843792
81SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.21653978
82SOX2_27498859_Chip-Seq_STOMACH_Mouse1.21115477
83* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19766977
84TP53_22127205_ChIP-Seq_IMR90_Human1.19541929
85KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.19338498
86GATA1_22025678_ChIP-Seq_K562_Human1.15716263
87NFIB_24661679_ChIP-Seq_LUNG_Mouse1.15308581
88TP63_22573176_ChIP-Seq_HFKS_Human1.13884918
89ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.13738572
90CJUN_26792858_Chip-Seq_BT549_Human1.13196173
91EGR1_19374776_ChIP-ChIP_THP-1_Human1.12693004
92PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.12638885
93GATA3_24758297_ChIP-Seq_MCF-7_Human1.12546661
94ZFP281_27345836_Chip-Seq_ESCs_Mouse1.12157277
95NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.11499008
96SA1_27219007_Chip-Seq_ERYTHROID_Human1.09950713
97SOX2_20726797_ChIP-Seq_SW620_Human1.09820444
98RARB_24833708_ChIP-Seq_LIVER_Mouse1.09401816
99KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.09248643
100TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08865182
101AHR_22903824_ChIP-Seq_MCF-7_Human1.08711419
102* ISL1_27105846_Chip-Seq_CPCs_Mouse1.08618846
103KLF5_25053715_ChIP-Seq_YYC3_Human1.08453939
104MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.08231089
105BP1_19119308_ChIP-ChIP_Hs578T_Human1.07439804
106SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.07367842
107DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.07007112
108GATA6_25053715_ChIP-Seq_YYC3_Human1.06974194
109CREB1_26743006_Chip-Seq_LNCaP_Human1.06218895
110ERG_21242973_ChIP-ChIP_JURKAT_Human1.06185139
111UBF1/2_26484160_Chip-Seq_HMECs_Human1.05360126
112STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.05050038
113NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.05006623
114CTCF_27219007_Chip-Seq_ERYTHROID_Human1.04356842
115* TET1_21490601_ChIP-Seq_MESCs_Mouse1.04195906
116JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03712016
117MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.03313181
118RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02720058
119SOX2_18692474_ChIP-Seq_MEFs_Mouse1.01751434
120TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01676454
121DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.01663078
122CTCF_27219007_Chip-Seq_Bcells_Human1.01050546
123CDX2_20551321_ChIP-Seq_CACO-2_Human1.00920613
124* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.99172424
125DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.99077516
126SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.98358498
127P68_20966046_ChIP-Seq_HELA_Human0.98250833
128ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.97769434
129EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.97339704
130FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.97218507
131STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.91906849
132VDR_21846776_ChIP-Seq_THP-1_Human0.89566667
133SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.88564919
134SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.88496038
135TP53_23651856_ChIP-Seq_MEFs_Mouse0.88120066

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004084_abnormal_cardiac_muscle4.70055145
2MP0000566_synostosis4.09894816
3MP0002837_dystrophic_cardiac_calcinosis3.57974721
4MP0004264_abnormal_extraembryonic_tissu3.11658942
5MP0000751_myopathy3.11321930
6MP0004272_abnormal_basement_membrane3.10752720
7MP0004036_abnormal_muscle_relaxation3.08452827
8MP0010368_abnormal_lymphatic_system2.65572977
9MP0003705_abnormal_hypodermis_morpholog2.62037158
10MP0003566_abnormal_cell_adhesion2.58178556
11MP0001958_emphysema2.55762583
12MP0004215_abnormal_myocardial_fiber2.53939338
13MP0005330_cardiomyopathy2.44983709
14MP0005076_abnormal_cell_differentiation2.38403862
15MP0010234_abnormal_vibrissa_follicle2.33782994
16MP0005360_urolithiasis2.32946654
17MP0009780_abnormal_chondrocyte_physiolo2.29547803
18MP0008775_abnormal_heart_ventricle2.26182003
19MP0005409_darkened_coat_color2.21308718
20MP0004782_abnormal_surfactant_physiolog2.20472197
21MP0002972_abnormal_cardiac_muscle2.18060505
22MP0006138_congestive_heart_failure2.13840774
23MP0005275_abnormal_skin_tensile2.07303918
24MP0000749_muscle_degeneration2.04449169
25MP0004087_abnormal_muscle_fiber2.02285278
26MP0000537_abnormal_urethra_morphology2.01899044
27MP0010630_abnormal_cardiac_muscle1.97081580
28MP0005385_cardiovascular_system_phenoty1.95633736
29MP0001544_abnormal_cardiovascular_syste1.95633736
30MP0001879_abnormal_lymphatic_vessel1.94766697
31MP0000750_abnormal_muscle_regeneration1.94390152
32MP0003646_muscle_fatigue1.93871261
33MP0005623_abnormal_meninges_morphology1.87087283
34MP0003828_pulmonary_edema1.86637742
35MP0002234_abnormal_pharynx_morphology1.81706537
36MP0000467_abnormal_esophagus_morphology1.78225394
37MP0002089_abnormal_postnatal_growth/wei1.75931592
38MP0002249_abnormal_larynx_morphology1.75618557
39MP0005620_abnormal_muscle_contractility1.67223503
40MP0009384_cardiac_valve_regurgitation1.64087999
41MP0002796_impaired_skin_barrier1.63250438
42MP0004130_abnormal_muscle_cell1.62203424
43MP0005167_abnormal_blood-brain_barrier1.59964267
44MP0005670_abnormal_white_adipose1.58618469
45MP0003137_abnormal_impulse_conducting1.53007376
46MP0004185_abnormal_adipocyte_glucose1.52334728
47MP0005058_abnormal_lysosome_morphology1.51947152
48MP0005451_abnormal_body_composition1.50958724
49MP0004381_abnormal_hair_follicle1.50956401
50MP0004484_altered_response_of1.50651539
51MP0003279_aneurysm1.50214605
52MP0000534_abnormal_ureter_morphology1.49818656
53MP0003122_maternal_imprinting1.47397371
54MP0010678_abnormal_skin_adnexa1.41961615
55MP0003942_abnormal_urinary_system1.40790298
56MP0001849_ear_inflammation1.39977007
57MP0002269_muscular_atrophy1.39521315
58MP0003941_abnormal_skin_development1.38652920
59MP0000383_abnormal_hair_follicle1.37192258
60MP0004858_abnormal_nervous_system1.36273420
61MP0008438_abnormal_cutaneous_collagen1.33740888
62MP0002138_abnormal_hepatobiliary_system1.31404239
63MP0000579_abnormal_nail_morphology1.31365399
64MP0002106_abnormal_muscle_physiology1.30288690
65MP0003315_abnormal_perineum_morphology1.28697217
66MP0004085_abnormal_heartbeat1.28379611
67MP0005165_increased_susceptibility_to1.26037082
68MP0010030_abnormal_orbit_morphology1.25507425
69MP0000747_muscle_weakness1.24777323
70MP0003283_abnormal_digestive_organ1.24447917
71MP0001216_abnormal_epidermal_layer1.22964436
72MP0000767_abnormal_smooth_muscle1.21622259
73MP0002127_abnormal_cardiovascular_syste1.21533003
74MP0010329_abnormal_lipoprotein_level1.19612108
75MP0000003_abnormal_adipose_tissue1.19183066
76MP0000377_abnormal_hair_follicle1.18715675
77MP0003950_abnormal_plasma_membrane1.18597700
78MP0005257_abnormal_intraocular_pressure1.18308521
79MP0005666_abnormal_adipose_tissue1.17935196
80MP0002108_abnormal_muscle_morphology1.16186332
81MP0004233_abnormal_muscle_weight1.15003032
82MP0001348_abnormal_lacrimal_gland1.14795839
83MP0000538_abnormal_urinary_bladder1.13257294
84MP0000343_altered_response_to1.12335918
85MP0000762_abnormal_tongue_morphology1.10702345
86MP0002166_altered_tumor_susceptibility1.10091780
87MP0000759_abnormal_skeletal_muscle1.08277586
88MP0005023_abnormal_wound_healing1.07850759
89MP0002925_abnormal_cardiovascular_devel1.06004920
90MP0003123_paternal_imprinting1.05743806
91MP0003567_abnormal_fetal_cardiomyocyte1.05452265
92MP0000266_abnormal_heart_morphology1.04276794
93MP0002128_abnormal_blood_circulation1.02766249
94MP0002295_abnormal_pulmonary_circulatio1.02073828
95MP0005369_muscle_phenotype1.01595825
96MP0000627_abnormal_mammary_gland1.01038070
97MP0000678_abnormal_parathyroid_gland0.99786519
98MP0005083_abnormal_biliary_tract0.98193411
99MP0010352_gastrointestinal_tract_polyps0.96466659
100MP0008961_abnormal_basal_metabolism0.95478869
101MP0005377_hearing/vestibular/ear_phenot0.95330399
102MP0003878_abnormal_ear_physiology0.95330399
103MP0001756_abnormal_urination0.94470434
104MP0005375_adipose_tissue_phenotype0.94113995
105MP0002098_abnormal_vibrissa_morphology0.94002972
106MP0004043_abnormal_pH_regulation0.93955491
107MP0005365_abnormal_bile_salt0.93455491
108MP0008004_abnormal_stomach_pH0.92677907
109MP0003115_abnormal_respiratory_system0.92593668
110MP0009672_abnormal_birth_weight0.92518996
111MP0008995_early_reproductive_senescence0.92343836
112MP0002909_abnormal_adrenal_gland0.91903592
113MP0003221_abnormal_cardiomyocyte_apopto0.90156123
114MP0002133_abnormal_respiratory_system0.89884899
115MP0005388_respiratory_system_phenotype0.89884899
116MP0002896_abnormal_bone_mineralization0.89251068
117MP0005501_abnormal_skin_physiology0.88597863
118MP0002060_abnormal_skin_morphology0.88006357
119MP0004145_abnormal_muscle_electrophysio0.86768906
120MP0009840_abnormal_foam_cell0.85759157
121MP0002332_abnormal_exercise_endurance0.85312169
122MP0000733_abnormal_muscle_development0.85200095
123MP0001614_abnormal_blood_vessel0.84658324
124MP0003091_abnormal_cell_migration0.82771752
125MP0009643_abnormal_urine_homeostasis0.82050424
126MP0003191_abnormal_cellular_cholesterol0.80809676
127MP0003453_abnormal_keratinocyte_physiol0.79767877
128MP0009278_abnormal_bone_marrow0.79404369
129MP0003879_abnormal_hair_cell0.79202689
130MP0006054_spinal_hemorrhage0.78771465
131MP0001666_abnormal_nutrient_absorption0.78409011
132MP0001661_extended_life_span0.76786535
133MP0009931_abnormal_skin_appearance0.76586641
134MP0008260_abnormal_autophagy0.76139035
135MP0002697_abnormal_eye_size0.75190351
136MP0002254_reproductive_system_inflammat0.75139472
137MP0001784_abnormal_fluid_regulation0.75138107
138MP0000462_abnormal_digestive_system0.74146826
139MP0000681_abnormal_thyroid_gland0.73705019
140MP0001765_abnormal_ion_homeostasis0.73095048
141MP0009053_abnormal_anal_canal0.73053409
142MP0000013_abnormal_adipose_tissue0.72111388
143MP0004019_abnormal_vitamin_homeostasis0.70957991
144MP0002116_abnormal_craniofacial_bone0.70451973
145MP0010771_integument_phenotype0.70381080
146MP0003172_abnormal_lysosome_physiology0.64667959
147MP0002111_abnormal_tail_morphology0.63932988

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)5.53647154
2Right ventricular cardiomyopathy (HP:0011663)5.17833182
3Ventricular tachycardia (HP:0004756)4.90060062
4Muscle fiber splitting (HP:0003555)4.61755948
5Deep venous thrombosis (HP:0002625)4.40249610
6Hyporeflexia of lower limbs (HP:0002600)4.30687826
7Increased connective tissue (HP:0009025)4.00346942
8Interstitial pulmonary disease (HP:0006530)3.95861035
9Milia (HP:0001056)3.69679339
10Onycholysis (HP:0001806)3.65082379
11Flat acetabular roof (HP:0003180)3.53159586
12Atrial fibrillation (HP:0005110)3.48624269
13Pili torti (HP:0003777)3.47701253
14Exercise-induced muscle cramps (HP:0003710)3.30441670
15Hyperactive renin-angiotensin system (HP:0000841)3.27360743
16Atrophic scars (HP:0001075)3.27211303
17Primary atrial arrhythmia (HP:0001692)3.27162004
18Broad face (HP:0000283)3.25705714
19Septate vagina (HP:0001153)3.25097290
20Advanced eruption of teeth (HP:0006288)3.22526019
21Asymmetry of the thorax (HP:0001555)3.21939853
22Supraventricular arrhythmia (HP:0005115)3.20374204
23Pterygium (HP:0001059)3.18807818
24Cervical subluxation (HP:0003308)3.17484091
25Broad metatarsal (HP:0001783)3.15908275
26Supraventricular tachycardia (HP:0004755)3.12764737
27Syncope (HP:0001279)3.10951985
28Distal lower limb muscle weakness (HP:0009053)3.08910375
29Lipoatrophy (HP:0100578)3.08446626
30Abnormality of the calf musculature (HP:0001430)3.07580588
31Asymmetric septal hypertrophy (HP:0001670)2.96621283
32Calf muscle hypertrophy (HP:0008981)2.94300183
33Mesangial abnormality (HP:0001966)2.93510405
34Cerebral aneurysm (HP:0004944)2.91695962
35Ventricular fibrillation (HP:0001663)2.90930149
36Abnormality of the left ventricular outflow tract (HP:0011103)2.89650887
37Subaortic stenosis (HP:0001682)2.89650887
38Palpitations (HP:0001962)2.87269030
39Exercise-induced myalgia (HP:0003738)2.85827462
40Difficulty climbing stairs (HP:0003551)2.85680849
41Fragile nails (HP:0001808)2.84462589
42Difficulty running (HP:0009046)2.78134152
43Ventricular arrhythmia (HP:0004308)2.76718312
44Lymphangioma (HP:0100764)2.68836741
45Polycythemia (HP:0001901)2.67201361
46Renal salt wasting (HP:0000127)2.65186830
47Ankle contracture (HP:0006466)2.62141267
48Alopecia of scalp (HP:0002293)2.60435281
49EMG: myopathic abnormalities (HP:0003458)2.60312483
50Prolonged QT interval (HP:0001657)2.55369432
51Testicular atrophy (HP:0000029)2.55335198
52Bundle branch block (HP:0011710)2.54693127
53Myoglobinuria (HP:0002913)2.53901586
54Type 1 muscle fiber predominance (HP:0003803)2.53815591
55Dilated cardiomyopathy (HP:0001644)2.52642830
56Mildly elevated creatine phosphokinase (HP:0008180)2.52038556
57Abnormality of carpal bone ossification (HP:0006257)2.51350526
58Muscle hypertrophy of the lower extremities (HP:0008968)2.50085649
59Hyperacusis (HP:0010780)2.48351346
60Goiter (HP:0000853)2.45301947
61Hemorrhage of the eye (HP:0011885)2.42466272
62Focal segmental glomerulosclerosis (HP:0000097)2.40886645
63Thin bony cortex (HP:0002753)2.39265056
64Hematochezia (HP:0002573)2.37672017
65J-shaped sella turcica (HP:0002680)2.33263291
66Increased variability in muscle fiber diameter (HP:0003557)2.30801630
67Obstructive sleep apnea (HP:0002870)2.29864716
68Atrioventricular block (HP:0001678)2.29453345
69Glomerulosclerosis (HP:0000096)2.29194600
70Protrusio acetabuli (HP:0003179)2.27513061
71Myotonia (HP:0002486)2.27270602
72Gout (HP:0001997)2.26666280
73Visceral angiomatosis (HP:0100761)2.26388323
74Natal tooth (HP:0000695)2.25963291
75Abnormal tarsal ossification (HP:0008369)2.25889544
76Amelogenesis imperfecta (HP:0000705)2.20951404
77Shallow orbits (HP:0000586)2.19995627
78Popliteal pterygium (HP:0009756)2.18030420
79Aplasia involving bones of the extremities (HP:0009825)2.15380311
80Aplasia involving bones of the upper limbs (HP:0009823)2.15380311
81Aplasia of the phalanges of the hand (HP:0009802)2.15380311
82Abnormal atrioventricular conduction (HP:0005150)2.14252676
83Heart block (HP:0012722)2.13126477
84Bronchomalacia (HP:0002780)2.09328240
85Hypoplasia of dental enamel (HP:0006297)2.08311718
86Abnormality of nail color (HP:0100643)2.08197422
87Plantar hyperkeratosis (HP:0007556)2.08086923
88Scapular winging (HP:0003691)2.07964674
89Abnormality of the foot musculature (HP:0001436)2.07383403
90Abnormality of skeletal muscle fiber size (HP:0012084)2.07331075
91Aneurysm (HP:0002617)2.06877484
92Hemangiomatosis (HP:0007461)2.06404158
93Nail dystrophy (HP:0008404)2.06018605
94Hypercholesterolemia (HP:0003124)2.05974158
95Abnormal ossification of hand bones (HP:0005921)2.05146771
96Rectal prolapse (HP:0002035)2.05064719
97Abnormality of chloride homeostasis (HP:0011422)2.03096038
98Prolonged partial thromboplastin time (HP:0003645)2.02918821
99Rapidly progressive (HP:0003678)2.01968832
100Foot dorsiflexor weakness (HP:0009027)2.01735264
101Back pain (HP:0003418)2.01650416
102Ulnar claw (HP:0001178)1.99220027
103Esophageal varix (HP:0002040)1.97962578
104Vascular calcification (HP:0004934)1.97752531
105Abnormality of the dental root (HP:0006486)1.97464503
106Taurodontia (HP:0000679)1.97464503
107Abnormality of permanent molar morphology (HP:0011071)1.97464503
108Palmoplantar keratoderma (HP:0000982)1.96871411
109Limb-girdle muscle atrophy (HP:0003797)1.95085311
110Tetany (HP:0001281)1.94527013
111Partial duplication of thumb phalanx (HP:0009944)1.94284964
112Long toe (HP:0010511)1.93925987
113Selective tooth agenesis (HP:0001592)1.92512093
114Acanthosis nigricans (HP:0000956)1.92294110
115Hypokalemic alkalosis (HP:0001949)1.92136138
116Spinal rigidity (HP:0003306)1.90799829
117Hyperaldosteronism (HP:0000859)1.90737318
118Conjunctival hamartoma (HP:0100780)1.90665817
119Tubulointerstitial fibrosis (HP:0005576)1.89689975
120Abnormality of the lacrimal duct (HP:0011481)1.89104938
121Biconcave vertebral bodies (HP:0004586)1.88230347
122Stridor (HP:0010307)1.87689195
123Abnormal hand bone ossification (HP:0010660)1.87404177
124Bifid scrotum (HP:0000048)1.87364698
125Respiratory distress (HP:0002098)1.85440232
126Abnormality of the distal phalanges of the toes (HP:0010182)1.85103571
127Abnormality of molar (HP:0011077)1.84697572
128Abnormality of molar morphology (HP:0011070)1.84697572
129Fragile skin (HP:0001030)1.84372718
130Joint hemorrhage (HP:0005261)1.84248369
131Germ cell neoplasia (HP:0100728)1.83717024
132Hypotrichosis (HP:0001006)1.82646681
133Abnormality of the Achilles tendon (HP:0005109)1.81972982
134Sudden cardiac death (HP:0001645)1.80105541
135Coxa vara (HP:0002812)1.79419607
136Pulmonary artery stenosis (HP:0004415)1.79121684
137Woolly hair (HP:0002224)1.78767338
138Abnormality of the distal phalanx of the thumb (HP:0009617)1.78084623
139Testicular neoplasm (HP:0010788)1.77759836
140Cavernous hemangioma (HP:0001048)1.77062128
141Laryngomalacia (HP:0001601)1.76991759
142Abnormality of the nasal mucosa (HP:0000433)1.76653295
143Absent eyelashes (HP:0000561)1.76237101
144Ulnar bowing (HP:0003031)1.76207917
145Neonatal death (HP:0003811)1.74942160
146EMG: neuropathic changes (HP:0003445)1.74690042
147Choanal stenosis (HP:0000452)1.74599137
148Facial shape deformation (HP:0011334)1.74419691
149Potter facies (HP:0002009)1.74419691
150Abnormality of the dental pulp (HP:0006479)1.73862983
151Flattened epiphyses (HP:0003071)1.73370806
152Abnormal hair laboratory examination (HP:0003328)1.73206988
153Aortic aneurysm (HP:0004942)1.73002264
154Generalized muscle weakness (HP:0003324)1.72553194
155Nasolacrimal duct obstruction (HP:0000579)1.72427318
156Down-sloping shoulders (HP:0200021)1.70553798
157Round ear (HP:0100830)1.70507260
158Complement deficiency (HP:0004431)1.70505163
159Oligodontia (HP:0000677)1.70496908
160Premature rupture of membranes (HP:0001788)1.70333808
161Tracheal stenosis (HP:0002777)1.70052848
162Short nail (HP:0001799)1.69746220
163Rhabdomyolysis (HP:0003201)1.69621808
164Easy fatigability (HP:0003388)1.68812545
165Cardiovascular calcification (HP:0011915)1.66291229
166Trismus (HP:0000211)1.65038725
167Abnormality of the salivary glands (HP:0010286)1.63192482
168Bulbar palsy (HP:0001283)1.58493894
169Glomerulonephritis (HP:0000099)1.57382948
170Abnormality of the axillary hair (HP:0100134)1.56899587
171Abnormality of secondary sexual hair (HP:0009888)1.56899587
172Achilles tendon contracture (HP:0001771)1.56705043
173Ulnar deviation of the wrist (HP:0003049)1.55862773
174Xanthomatosis (HP:0000991)1.55182008

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE14.05964452
2TTN3.94127560
3TRIB33.54176249
4LMTK23.30145114
5MYLK2.98666630
6PKN22.80357613
7EPHA22.64780952
8RIPK12.46312818
9SMG12.37492137
10EPHB22.16100828
11TGFBR22.15967414
12WNK42.07019718
13MAPKAPK32.04256429
14PHKG11.98124158
15PHKG21.98124158
16FER1.93358213
17DMPK1.89504692
18CAMK1G1.88239830
19PDGFRA1.78053201
20EPHB11.76167220
21PAK41.73205299
22NEK11.71513533
23TNK21.71324758
24LRRK21.66902061
25STK241.59037323
26PDK31.58711627
27PDK41.58711627
28ERN11.46196907
29LATS11.44739717
30MARK21.42949978
31PRKD21.41103261
32PTK61.39934472
33ILK1.35104783
34NME11.31633853
35MUSK1.29763323
36LATS21.29580388
37DDR21.27490514
38IRAK31.25887207
39KDR1.24222834
40MAP3K31.23721882
41KSR21.19304659
42TGFBR11.15801810
43FGFR41.14896592
44STK38L1.12693121
45PTK21.11380909
46PDK21.10202864
47FGFR21.08585534
48MET1.05658628
49OBSCN1.05334179
50RPS6KB21.05027834
51PIM21.04778243
52PRKD11.03734355
53MAP3K21.02353769
54BCKDK0.98555187
55ARAF0.89670058
56ROCK10.86888486
57PAK30.85100340
58MAP2K20.84686566
59SIK10.83044368
60CDC42BPA0.83031260
61MAP2K30.83018580
62STK390.78879990
63RET0.78539719
64NTRK10.77316337
65EPHA30.77130331
66ERBB20.76922856
67ICK0.74386673
68PDGFRB0.73754272
69MAPK150.73591311
70STK100.73302820
71DAPK30.73285112
72TRPM70.72675344
73PRKAA20.72403048
74CDK70.72208615
75MAP3K70.71514868
76MST1R0.70955299
77MAP2K10.69653740
78PRKG20.69120969
79CHUK0.63666710
80FGFR10.62693502
81MTOR0.62610309
82PRKAA10.62091091
83STK380.61990265
84PTK2B0.61922834
85FLT30.61238163
86MAP3K60.60195487
87CAMK1D0.60130936
88TYRO30.59935497
89BMX0.57938547
90PIK3CA0.57368457
91MAP3K110.56362894
92MAP2K60.56201458
93LIMK10.55637627
94MAP3K10.55082514
95MST40.54751254
96ROCK20.52628485
97MAP3K100.52512721
98HIPK20.51531387
99PAK20.50792156
100RPS6KL10.49176888
101RPS6KC10.49176888
102EEF2K0.48085763
103RPS6KA20.47485693
104WNK10.47433638
105FGFR30.47418360
106MATK0.47382843
107MAP3K90.46779251
108CDK120.46750631
109GSK3A0.46229474
110TESK10.45302517
111RPS6KA60.40078934
112DYRK1B0.39220497
113RPS6KA10.38248852
114AKT30.37603166
115MAPK80.37006105
116PRKD30.36539132
117PDPK10.36503359
118PRKCI0.34696600
119CAMK10.34274908
120MAP3K80.34184737
121MAPKAPK20.33272448
122WNK30.32738192
123CAMK40.32214619
124TAOK10.31611669
125NEK60.31135247
126CAMK2G0.29680241
127NME20.29193954
128AKT20.28545878
129SGK30.27152902
130PRKCZ0.23585054
131MAPK110.21939922
132SCYL20.21885037
133IRAK20.21256027
134CDK90.20037800

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.89866970
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.07342375
3Dilated cardiomyopathy_Homo sapiens_hsa054143.01125018
4Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.95663845
5ECM-receptor interaction_Homo sapiens_hsa045122.87200046
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.73180183
7Cyanoamino acid metabolism_Homo sapiens_hsa004602.33838852
8Focal adhesion_Homo sapiens_hsa045102.21762050
9Cardiac muscle contraction_Homo sapiens_hsa042602.11254471
10Other glycan degradation_Homo sapiens_hsa005112.03254995
11Adherens junction_Homo sapiens_hsa045201.99424388
12Steroid biosynthesis_Homo sapiens_hsa001001.92359693
13Tight junction_Homo sapiens_hsa045301.92033744
14Fatty acid degradation_Homo sapiens_hsa000711.89966765
15Glycosaminoglycan degradation_Homo sapiens_hsa005311.89134075
16Complement and coagulation cascades_Homo sapiens_hsa046101.86099061
17Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.83500210
18Phenylalanine metabolism_Homo sapiens_hsa003601.75876514
19Amoebiasis_Homo sapiens_hsa051461.69883651
20Arginine biosynthesis_Homo sapiens_hsa002201.65650778
21Hippo signaling pathway_Homo sapiens_hsa043901.60636852
22Small cell lung cancer_Homo sapiens_hsa052221.57466480
23Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.56614586
24Viral myocarditis_Homo sapiens_hsa054161.56082478
25Propanoate metabolism_Homo sapiens_hsa006401.50780098
26Protein digestion and absorption_Homo sapiens_hsa049741.44854320
27Proteoglycans in cancer_Homo sapiens_hsa052051.43695375
28Basal cell carcinoma_Homo sapiens_hsa052171.41784251
29Histidine metabolism_Homo sapiens_hsa003401.41199334
30Carbon metabolism_Homo sapiens_hsa012001.39814696
31Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.37755941
32AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.37247651
33Leukocyte transendothelial migration_Homo sapiens_hsa046701.35793794
34Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.31809702
35Fatty acid metabolism_Homo sapiens_hsa012121.31458463
36Bladder cancer_Homo sapiens_hsa052191.28523789
37Vitamin digestion and absorption_Homo sapiens_hsa049771.25947121
38Dorso-ventral axis formation_Homo sapiens_hsa043201.20273340
39ABC transporters_Homo sapiens_hsa020101.18037612
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.17761213
41Central carbon metabolism in cancer_Homo sapiens_hsa052301.17724576
42Insulin resistance_Homo sapiens_hsa049311.16635172
43Thyroid hormone synthesis_Homo sapiens_hsa049181.15761454
44Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.14891991
45Fructose and mannose metabolism_Homo sapiens_hsa000511.14368880
46Hedgehog signaling pathway_Homo sapiens_hsa043401.13573544
47Notch signaling pathway_Homo sapiens_hsa043301.13514229
48Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.13497872
49Thyroid cancer_Homo sapiens_hsa052161.07837224
50N-Glycan biosynthesis_Homo sapiens_hsa005101.06990798
51Regulation of actin cytoskeleton_Homo sapiens_hsa048101.06560776
52Arginine and proline metabolism_Homo sapiens_hsa003301.05283147
53VEGF signaling pathway_Homo sapiens_hsa043701.04640158
54Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.03212742
55Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.02185117
56Thyroid hormone signaling pathway_Homo sapiens_hsa049190.99668895
57Pyruvate metabolism_Homo sapiens_hsa006200.99506248
58Adipocytokine signaling pathway_Homo sapiens_hsa049200.96870587
59Insulin signaling pathway_Homo sapiens_hsa049100.95939075
60Tyrosine metabolism_Homo sapiens_hsa003500.94628425
61Mineral absorption_Homo sapiens_hsa049780.93257055
62Gastric acid secretion_Homo sapiens_hsa049710.93207265
63Rap1 signaling pathway_Homo sapiens_hsa040150.92281540
64Galactose metabolism_Homo sapiens_hsa000520.90386177
65Prostate cancer_Homo sapiens_hsa052150.89603592
66Pathways in cancer_Homo sapiens_hsa052000.88775789
67Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.88630052
68cGMP-PKG signaling pathway_Homo sapiens_hsa040220.87775488
69Renal cell carcinoma_Homo sapiens_hsa052110.87624301
70Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.86820905
71PI3K-Akt signaling pathway_Homo sapiens_hsa041510.86292858
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.84137751
73Sphingolipid metabolism_Homo sapiens_hsa006000.83483226
74ErbB signaling pathway_Homo sapiens_hsa040120.83420026
75Toxoplasmosis_Homo sapiens_hsa051450.82911154
76HIF-1 signaling pathway_Homo sapiens_hsa040660.82893891
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.82324288
78Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.81483742
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.80014285
80Endometrial cancer_Homo sapiens_hsa052130.78537623
81TGF-beta signaling pathway_Homo sapiens_hsa043500.78354778
82Fatty acid biosynthesis_Homo sapiens_hsa000610.76019319
83Fat digestion and absorption_Homo sapiens_hsa049750.75290073
84Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.75129911
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.73059924
86Bile secretion_Homo sapiens_hsa049760.72744987
87PPAR signaling pathway_Homo sapiens_hsa033200.71982202
88Melanogenesis_Homo sapiens_hsa049160.71706422
89AMPK signaling pathway_Homo sapiens_hsa041520.70427725
90Glucagon signaling pathway_Homo sapiens_hsa049220.70043239
91mTOR signaling pathway_Homo sapiens_hsa041500.69826550
92Prion diseases_Homo sapiens_hsa050200.69778781
93Ovarian steroidogenesis_Homo sapiens_hsa049130.68406732
94Axon guidance_Homo sapiens_hsa043600.66312262
95Aldosterone synthesis and secretion_Homo sapiens_hsa049250.65071573
96Choline metabolism in cancer_Homo sapiens_hsa052310.65034071
97Lysine degradation_Homo sapiens_hsa003100.64320177
98Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.63831240
99Melanoma_Homo sapiens_hsa052180.62826485
100Platelet activation_Homo sapiens_hsa046110.61904176
101Estrogen signaling pathway_Homo sapiens_hsa049150.60699038
102Glycerophospholipid metabolism_Homo sapiens_hsa005640.60227986
103Renin secretion_Homo sapiens_hsa049240.58489610
104MicroRNAs in cancer_Homo sapiens_hsa052060.57124164
105Non-small cell lung cancer_Homo sapiens_hsa052230.57076489
106Sulfur relay system_Homo sapiens_hsa041220.56906438
107Vibrio cholerae infection_Homo sapiens_hsa051100.56606403
108Renin-angiotensin system_Homo sapiens_hsa046140.56044024
109Gap junction_Homo sapiens_hsa045400.55017729
110Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.54814469
111Biosynthesis of amino acids_Homo sapiens_hsa012300.54451465
112Pentose phosphate pathway_Homo sapiens_hsa000300.53217842
113Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.53208832
114Chronic myeloid leukemia_Homo sapiens_hsa052200.52862428
115Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.52003541
116Parkinsons disease_Homo sapiens_hsa050120.50402517
117Starch and sucrose metabolism_Homo sapiens_hsa005000.48940876
118Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46680078
119Pentose and glucuronate interconversions_Homo sapiens_hsa000400.46498771
120Endocytosis_Homo sapiens_hsa041440.45758748
121Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.45454800
122Salmonella infection_Homo sapiens_hsa051320.43915000
123Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42989698
124Acute myeloid leukemia_Homo sapiens_hsa052210.41246004
125Pancreatic cancer_Homo sapiens_hsa052120.40292504
126Neurotrophin signaling pathway_Homo sapiens_hsa047220.38594721
127Tryptophan metabolism_Homo sapiens_hsa003800.38554534
128Glioma_Homo sapiens_hsa052140.37831967
129Oxytocin signaling pathway_Homo sapiens_hsa049210.36642841
130Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34765414
131GnRH signaling pathway_Homo sapiens_hsa049120.34327888
132Fatty acid elongation_Homo sapiens_hsa000620.33894378
133Wnt signaling pathway_Homo sapiens_hsa043100.32992767
134Alzheimers disease_Homo sapiens_hsa050100.32608200
135Phospholipase D signaling pathway_Homo sapiens_hsa040720.31749724
136Lysosome_Homo sapiens_hsa041420.30400397
137cAMP signaling pathway_Homo sapiens_hsa040240.30019977

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