BBIP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of eight proteins that form the BBSome complex and is essential for its assembly. The BBSome complex is involved in trafficking signal receptors to and from the cilia. Mutations in this gene result in Bardet-Biedl syndrome 18. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.24058278
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.87830746
3presynaptic membrane assembly (GO:0097105)4.79435079
4ATP synthesis coupled proton transport (GO:0015986)4.74326737
5energy coupled proton transport, down electrochemical gradient (GO:0015985)4.74326737
6presynaptic membrane organization (GO:0097090)4.47926302
7respiratory electron transport chain (GO:0022904)4.30423779
8behavioral response to nicotine (GO:0035095)4.24397007
9electron transport chain (GO:0022900)4.19707497
10central nervous system myelination (GO:0022010)4.18751976
11axon ensheathment in central nervous system (GO:0032291)4.18751976
12GTP biosynthetic process (GO:0006183)4.14789095
13neuron cell-cell adhesion (GO:0007158)4.14660752
14indolalkylamine metabolic process (GO:0006586)3.95563968
15protein neddylation (GO:0045116)3.95431084
16protein complex biogenesis (GO:0070271)3.90563077
17neural tube formation (GO:0001841)3.66556821
18chaperone-mediated protein transport (GO:0072321)3.63222346
19mitochondrial respiratory chain complex I assembly (GO:0032981)3.58905231
20NADH dehydrogenase complex assembly (GO:0010257)3.58905231
21mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.58905231
22postsynaptic membrane organization (GO:0001941)3.53033339
23epithelial cilium movement (GO:0003351)3.47750490
24cilium movement (GO:0003341)3.43132772
25mitochondrial respiratory chain complex assembly (GO:0033108)3.42461883
26pyrimidine nucleobase catabolic process (GO:0006208)3.41745764
27water-soluble vitamin biosynthetic process (GO:0042364)3.35669721
28axonemal dynein complex assembly (GO:0070286)3.34766179
29respiratory chain complex IV assembly (GO:0008535)3.23378057
30long-chain fatty acid biosynthetic process (GO:0042759)3.20192635
31cilium morphogenesis (GO:0060271)3.16436729
32platelet dense granule organization (GO:0060155)3.15976647
33UTP biosynthetic process (GO:0006228)3.10627901
34serotonin metabolic process (GO:0042428)3.06680958
35detection of light stimulus involved in visual perception (GO:0050908)3.05954797
36detection of light stimulus involved in sensory perception (GO:0050962)3.05954797
37L-fucose catabolic process (GO:0042355)3.04456561
38fucose catabolic process (GO:0019317)3.04456561
39L-fucose metabolic process (GO:0042354)3.04456561
40nucleobase catabolic process (GO:0046113)3.02465526
41negative regulation of execution phase of apoptosis (GO:1900118)3.01445539
42indole-containing compound catabolic process (GO:0042436)3.01162756
43indolalkylamine catabolic process (GO:0046218)3.01162756
44tryptophan catabolic process (GO:0006569)3.01162756
45intraciliary transport (GO:0042073)3.01009794
46response to pheromone (GO:0019236)3.00438577
47cytochrome complex assembly (GO:0017004)2.99082821
48cellular ketone body metabolic process (GO:0046950)2.98513049
49primary amino compound metabolic process (GO:1901160)2.97154881
50detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.94207062
51hydrogen ion transmembrane transport (GO:1902600)2.93904327
52axoneme assembly (GO:0035082)2.93462874
53neuronal action potential propagation (GO:0019227)2.91933580
54negative regulation of neurotransmitter transport (GO:0051589)2.90023410
55protein K11-linked deubiquitination (GO:0035871)2.87925264
56indole-containing compound metabolic process (GO:0042430)2.86378065
57tryptophan metabolic process (GO:0006568)2.85273997
58nonmotile primary cilium assembly (GO:0035058)2.84878589
59kidney morphogenesis (GO:0060993)2.82955036
60cerebral cortex radially oriented cell migration (GO:0021799)2.82404391
61guanosine-containing compound biosynthetic process (GO:1901070)2.81834693
62regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.81130100
63mannosylation (GO:0097502)2.80478193
64nucleoside diphosphate phosphorylation (GO:0006165)2.80217567
65alkaloid metabolic process (GO:0009820)2.79969679
66GPI anchor biosynthetic process (GO:0006506)2.79770015
67CTP metabolic process (GO:0046036)2.78917767
68CTP biosynthetic process (GO:0006241)2.78917767
69inositol phosphate catabolic process (GO:0071545)2.76852706
70proton transport (GO:0015992)2.76326784
71negative regulation of cytosolic calcium ion concentration (GO:0051481)2.75318881
72protein localization to cilium (GO:0061512)2.74579183
73protein localization to synapse (GO:0035418)2.72703374
74ketone body metabolic process (GO:1902224)2.72587706
75substantia nigra development (GO:0021762)2.72039147
76regulation of cilium movement (GO:0003352)2.71272366
77neuronal action potential (GO:0019228)2.69287968
78hydrogen transport (GO:0006818)2.68449374
79magnesium ion transport (GO:0015693)2.68016889
80regulation of action potential (GO:0098900)2.66796796
81retinal ganglion cell axon guidance (GO:0031290)2.66240491
82positive regulation of synapse assembly (GO:0051965)2.65648829
83establishment of protein localization to Golgi (GO:0072600)2.65061308
84cornea development in camera-type eye (GO:0061303)2.64517419
85regulation of pigment cell differentiation (GO:0050932)2.64045657
86purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.63885938
87behavioral response to ethanol (GO:0048149)2.62832937
88protein-cofactor linkage (GO:0018065)2.62424615
89dendritic spine morphogenesis (GO:0060997)2.62064231
90somite development (GO:0061053)2.61440560
91developmental pigmentation (GO:0048066)2.61308502
92neuron recognition (GO:0008038)2.59880947
93photoreceptor cell maintenance (GO:0045494)2.58591911
94signal peptide processing (GO:0006465)2.57766559
95protein polyglutamylation (GO:0018095)2.57443239
96glycosphingolipid biosynthetic process (GO:0006688)2.54883642
97UTP metabolic process (GO:0046051)2.54798436
98reflex (GO:0060004)2.54287928
99positive regulation of oligodendrocyte differentiation (GO:0048714)2.54097433
100purine nucleoside triphosphate biosynthetic process (GO:0009145)2.53697651
101preassembly of GPI anchor in ER membrane (GO:0016254)2.53147900
102transcription elongation from RNA polymerase III promoter (GO:0006385)2.52855861
103termination of RNA polymerase III transcription (GO:0006386)2.52855861
104GPI anchor metabolic process (GO:0006505)2.52706160
105negative regulation of calcium ion transport into cytosol (GO:0010523)2.51427078
106kynurenine metabolic process (GO:0070189)2.51154260
107regulation of dopamine metabolic process (GO:0042053)2.50602765
108regulation of catecholamine metabolic process (GO:0042069)2.50602765
109cullin deneddylation (GO:0010388)2.50210232
110DNA deamination (GO:0045006)2.49420544
111negative regulation of transcription regulatory region DNA binding (GO:2000678)2.48780956
112limb bud formation (GO:0060174)2.48228795
113cilium or flagellum-dependent cell motility (GO:0001539)2.47286765
114G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.46659753
115gamma-aminobutyric acid transport (GO:0015812)2.46442760
116hindbrain development (GO:0030902)2.46385231
117piRNA metabolic process (GO:0034587)2.45279539
118regulation of hexokinase activity (GO:1903299)2.44809281
119regulation of glucokinase activity (GO:0033131)2.44809281
120phosphorylated carbohydrate dephosphorylation (GO:0046838)2.43888039
121inositol phosphate dephosphorylation (GO:0046855)2.43888039
122negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.43697720
123RNA destabilization (GO:0050779)2.43459876
124positive regulation of protein homodimerization activity (GO:0090073)2.43382802
125keratinocyte development (GO:0003334)2.43117688
126nephron epithelium morphogenesis (GO:0072088)2.42603657
127nephron tubule morphogenesis (GO:0072078)2.42603657
128regulation of mitochondrial translation (GO:0070129)2.42305944
129polyol catabolic process (GO:0046174)2.41901438
130synaptic transmission, cholinergic (GO:0007271)2.41794035
131spinal cord motor neuron differentiation (GO:0021522)2.41666465
132retinal cone cell development (GO:0046549)2.41661849
133prenylation (GO:0097354)2.41343849
134protein prenylation (GO:0018342)2.41343849
135negative regulation of neurotransmitter secretion (GO:0046929)2.40401033
136centriole replication (GO:0007099)2.39812013
137negative regulation of synaptic transmission, GABAergic (GO:0032229)2.39393243
138regulation of neurotransmitter uptake (GO:0051580)2.39365635
139startle response (GO:0001964)2.37850317
140protein targeting to Golgi (GO:0000042)2.37563874
141spermatid nucleus differentiation (GO:0007289)2.36259511
142response to redox state (GO:0051775)2.32774741
143transmission of nerve impulse (GO:0019226)2.32724710
144fatty acid elongation (GO:0030497)2.32452362
145* cilium assembly (GO:0042384)2.32204964
146proteasome assembly (GO:0043248)2.31910237
147epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.28952813
148regulation of respiratory system process (GO:0044065)2.28516197
149regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.27454856
150establishment of protein localization to mitochondrial membrane (GO:0090151)2.26424325
1517-methylguanosine RNA capping (GO:0009452)2.25555520
152RNA capping (GO:0036260)2.25555520
153anterograde synaptic vesicle transport (GO:0048490)2.25260756
154* cilium organization (GO:0044782)2.24250598
155neuron fate determination (GO:0048664)2.24130273
156neurotransmitter uptake (GO:0001504)2.21950430
157protein deneddylation (GO:0000338)2.20960517
158regulation of axon regeneration (GO:0048679)2.20887703
159regulation of neuron projection regeneration (GO:0070570)2.20887703
160ATP biosynthetic process (GO:0006754)2.20770750
161phagosome maturation (GO:0090382)2.20140722
1627-methylguanosine mRNA capping (GO:0006370)2.18959158
163ATP hydrolysis coupled proton transport (GO:0015991)2.18235041
164energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.18235041
165ribonucleoside triphosphate biosynthetic process (GO:0009201)2.18016819
166C-terminal protein lipidation (GO:0006501)2.17798630
167ionotropic glutamate receptor signaling pathway (GO:0035235)2.17684743
168dopamine biosynthetic process (GO:0042416)2.16891878

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.05879107
2GBX2_23144817_ChIP-Seq_PC3_Human3.50806081
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.95323692
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.91248493
5TAF15_26573619_Chip-Seq_HEK293_Human2.81894543
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.66849225
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.66120723
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.45067699
9VDR_22108803_ChIP-Seq_LS180_Human2.44011084
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.34330272
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.33806585
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.26931414
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.24784496
14BMI1_23680149_ChIP-Seq_NPCS_Mouse2.17387634
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.09377676
16PCGF2_27294783_Chip-Seq_ESCs_Mouse1.99422217
17CBX2_27304074_Chip-Seq_ESCs_Mouse1.99308713
18JARID2_20064375_ChIP-Seq_MESCs_Mouse1.97595911
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.97579199
20P300_19829295_ChIP-Seq_ESCs_Human1.91497702
21FUS_26573619_Chip-Seq_HEK293_Human1.90472097
22CTBP2_25329375_ChIP-Seq_LNCAP_Human1.89889621
23EZH2_27304074_Chip-Seq_ESCs_Mouse1.88099061
24AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.87951261
25SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.84295962
26KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.83771262
27ER_23166858_ChIP-Seq_MCF-7_Human1.81606263
28RNF2_27304074_Chip-Seq_NSC_Mouse1.79242379
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.79131403
30IGF1R_20145208_ChIP-Seq_DFB_Human1.70218408
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.63185870
32HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.63069685
33GABP_17652178_ChIP-ChIP_JURKAT_Human1.62976072
34SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.60395619
35EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.59742968
36NANOG_18555785_Chip-Seq_ESCs_Mouse1.59717867
37SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.58886694
38SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.58415558
39BCAT_22108803_ChIP-Seq_LS180_Human1.58130501
40EED_16625203_ChIP-ChIP_MESCs_Mouse1.56272764
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.55542249
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.54392614
43TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.53092020
44SUZ12_18555785_Chip-Seq_ESCs_Mouse1.53086212
45P53_22387025_ChIP-Seq_ESCs_Mouse1.51625597
46SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.51405788
47OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.51146005
48IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.50917334
49CBP_20019798_ChIP-Seq_JUKART_Human1.50917334
50TOP2B_26459242_ChIP-Seq_MCF-7_Human1.50529726
51AR_25329375_ChIP-Seq_VCAP_Human1.48159010
52SUZ12_27294783_Chip-Seq_NPCs_Mouse1.47349956
53STAT3_23295773_ChIP-Seq_U87_Human1.46439706
54MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.46371739
55SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.44981373
56E2F1_18555785_Chip-Seq_ESCs_Mouse1.44899804
57CMYC_18555785_Chip-Seq_ESCs_Mouse1.43982713
58P300_18555785_Chip-Seq_ESCs_Mouse1.43669557
59SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43661712
60STAT3_18555785_Chip-Seq_ESCs_Mouse1.43415807
61BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.43317012
62JARID2_20075857_ChIP-Seq_MESCs_Mouse1.42429772
63EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.42268325
64NR3C1_21868756_ChIP-Seq_MCF10A_Human1.41359875
65EWS_26573619_Chip-Seq_HEK293_Human1.40558478
66EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.39327130
67TP53_22573176_ChIP-Seq_HFKS_Human1.38474858
68AR_21572438_ChIP-Seq_LNCaP_Human1.37888194
69PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.37445848
70REST_21632747_ChIP-Seq_MESCs_Mouse1.37268648
71TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36968042
72POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.36968042
73TAL1_26923725_Chip-Seq_HPCs_Mouse1.36932476
74NFE2_27457419_Chip-Seq_LIVER_Mouse1.36919326
75TCF4_23295773_ChIP-Seq_U87_Human1.36818010
76CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.36439966
77EZH2_27294783_Chip-Seq_ESCs_Mouse1.35938471
78NMYC_18555785_Chip-Seq_ESCs_Mouse1.35634368
79SUZ12_27294783_Chip-Seq_ESCs_Mouse1.35387527
80SOX2_18555785_Chip-Seq_ESCs_Mouse1.33354219
81SMAD3_21741376_ChIP-Seq_EPCs_Human1.32872661
82GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.32824042
83EZH2_27294783_Chip-Seq_NPCs_Mouse1.32146890
84FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.32043904
85IRF1_19129219_ChIP-ChIP_H3396_Human1.30980062
86SMAD4_21799915_ChIP-Seq_A2780_Human1.30803258
87RUNX1_27457419_Chip-Seq_LIVER_Mouse1.30587430
88RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.29751504
89SOX2_19829295_ChIP-Seq_ESCs_Human1.27039376
90NANOG_19829295_ChIP-Seq_ESCs_Human1.27039376
91EST1_17652178_ChIP-ChIP_JURKAT_Human1.26781208
92PCGF2_27294783_Chip-Seq_NPCs_Mouse1.26489478
93SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.25650557
94UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25161066
95NOTCH1_21737748_ChIP-Seq_TLL_Human1.25077259
96RUNX2_22187159_ChIP-Seq_PCA_Human1.24938416
97TCF4_22108803_ChIP-Seq_LS180_Human1.24676739
98NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.21909343
99ELF1_17652178_ChIP-ChIP_JURKAT_Human1.21756209
100NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.21534611
101RNF2_18974828_ChIP-Seq_MESCs_Mouse1.21124003
102EZH2_18974828_ChIP-Seq_MESCs_Mouse1.21124003
103ZFX_18555785_Chip-Seq_ESCs_Mouse1.20905702
104FLI1_21867929_ChIP-Seq_TH2_Mouse1.18303416
105RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.18136734
106PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.18090498
107MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17933142
108OCT4_18555785_Chip-Seq_ESCs_Mouse1.17868134
109MTF2_20144788_ChIP-Seq_MESCs_Mouse1.17727450
110KLF4_18555785_Chip-Seq_ESCs_Mouse1.16803953
111SMAD1_18555785_Chip-Seq_ESCs_Mouse1.16418061
112PRDM14_20953172_ChIP-Seq_ESCs_Human1.16381107
113CDX2_19796622_ChIP-Seq_MESCs_Mouse1.16135303
114KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16058759
115FOXA1_21572438_ChIP-Seq_LNCaP_Human1.14566855
116FOXA1_25329375_ChIP-Seq_VCAP_Human1.14463661
117FOXA1_27270436_Chip-Seq_PROSTATE_Human1.14463661
118TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14422167
119RNF2_27304074_Chip-Seq_ESCs_Mouse1.13787912
120EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.13736201
121PIAS1_25552417_ChIP-Seq_VCAP_Human1.12472811
122CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.12338864
123ELK1_19687146_ChIP-ChIP_HELA_Human1.12293954
124RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11384901
125PU1_27457419_Chip-Seq_LIVER_Mouse1.10193351
126CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10182740
127GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.10166734
128MYC_18940864_ChIP-ChIP_HL60_Human1.09058035
129CTCF_18555785_Chip-Seq_ESCs_Mouse1.07281903
130SMAD4_21741376_ChIP-Seq_EPCs_Human1.05392002
131HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.05375760
132POU5F1_16153702_ChIP-ChIP_HESCs_Human1.04283393
133JUN_21703547_ChIP-Seq_K562_Human1.04145791
134KDM2B_26808549_Chip-Seq_REH_Human1.03948920
135ESRRB_18555785_Chip-Seq_ESCs_Mouse1.03641877
136ZNF274_21170338_ChIP-Seq_K562_Hela1.03479971
137CRX_20693478_ChIP-Seq_RETINA_Mouse1.03257944
138ETV2_25802403_ChIP-Seq_MESCs_Mouse1.00528815
139SOX2_21211035_ChIP-Seq_LN229_Gbm0.97950469
140NCOR_22424771_ChIP-Seq_293T_Human0.97939405

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.40069194
2MP0000569_abnormal_digit_pigmentation3.77527641
3MP0009379_abnormal_foot_pigmentation3.09266989
4MP0003787_abnormal_imprinting2.95145366
5MP0001188_hyperpigmentation2.83160280
6MP0006276_abnormal_autonomic_nervous2.78281777
7MP0008877_abnormal_DNA_methylation2.66968029
8MP0001529_abnormal_vocalization2.65694481
9MP0001905_abnormal_dopamine_level2.42208793
10MP0003195_calcinosis2.38702630
11MP0006292_abnormal_olfactory_placode2.38463214
12MP0001984_abnormal_olfaction2.35849909
13MP0005423_abnormal_somatic_nervous2.29355117
14MP0005409_darkened_coat_color2.27067462
15MP0003136_yellow_coat_color2.14733123
16MP0004270_analgesia2.11069729
17MP0002734_abnormal_mechanical_nocicepti2.07700894
18MP0002837_dystrophic_cardiac_calcinosis2.07330684
19MP0009745_abnormal_behavioral_response2.05516270
20MP0001968_abnormal_touch/_nociception2.00872807
21MP0000778_abnormal_nervous_system1.98204235
22MP0002272_abnormal_nervous_system1.96742097
23MP0002638_abnormal_pupillary_reflex1.96733399
24MP0001986_abnormal_taste_sensitivity1.93736182
25MP0005645_abnormal_hypothalamus_physiol1.92725372
26MP0002735_abnormal_chemical_nociception1.90493840
27MP0005646_abnormal_pituitary_gland1.89199096
28MP0001486_abnormal_startle_reflex1.88472947
29MP0003635_abnormal_synaptic_transmissio1.84689088
30MP0002064_seizures1.83487957
31MP0002736_abnormal_nociception_after1.82534957
32MP0004742_abnormal_vestibular_system1.78863569
33MP0002572_abnormal_emotion/affect_behav1.77837556
34MP0002102_abnormal_ear_morphology1.75626507
35MP0001485_abnormal_pinna_reflex1.72050466
36MP0003121_genomic_imprinting1.69990423
37MP0000015_abnormal_ear_pigmentation1.68245487
38MP0002063_abnormal_learning/memory/cond1.61407075
39MP0009046_muscle_twitch1.61356318
40MP0003011_delayed_dark_adaptation1.60134461
41MP0005171_absent_coat_pigmentation1.58867404
42MP0004142_abnormal_muscle_tone1.57932981
43MP0002163_abnormal_gland_morphology1.57580073
44MP0010386_abnormal_urinary_bladder1.51374985
45MP0008789_abnormal_olfactory_epithelium1.50513426
46MP0002067_abnormal_sensory_capabilities1.50374404
47MP0000920_abnormal_myelination1.49880023
48MP0005379_endocrine/exocrine_gland_phen1.49732683
49MP0001970_abnormal_pain_threshold1.48784800
50MP0002876_abnormal_thyroid_physiology1.47749648
51MP0004133_heterotaxia1.46183012
52MP0005410_abnormal_fertilization1.42465751
53MP0005551_abnormal_eye_electrophysiolog1.42294581
54MP0006072_abnormal_retinal_apoptosis1.36643313
55MP0000631_abnormal_neuroendocrine_gland1.33540111
56MP0001440_abnormal_grooming_behavior1.32335367
57MP0000372_irregular_coat_pigmentation1.32228650
58MP0002909_abnormal_adrenal_gland1.32184334
59MP0000427_abnormal_hair_cycle1.31541441
60MP0002557_abnormal_social/conspecific_i1.31007915
61MP0004859_abnormal_synaptic_plasticity1.29235501
62MP0004381_abnormal_hair_follicle1.27417315
63MP0001502_abnormal_circadian_rhythm1.27262024
64MP0005499_abnormal_olfactory_system1.27236140
65MP0005394_taste/olfaction_phenotype1.27236140
66MP0002928_abnormal_bile_duct1.27147039
67MP0000026_abnormal_inner_ear1.26398556
68MP0002184_abnormal_innervation1.24706092
69MP0002733_abnormal_thermal_nociception1.24272658
70MP0001963_abnormal_hearing_physiology1.22907947
71MP0008872_abnormal_physiological_respon1.21919559
72MP0005253_abnormal_eye_physiology1.17593685
73MP0002653_abnormal_ependyma_morphology1.17155855
74MP0005174_abnormal_tail_pigmentation1.16922061
75MP0005389_reproductive_system_phenotype1.15659374
76MP0001501_abnormal_sleep_pattern1.15657071
77MP0004924_abnormal_behavior1.14202132
78MP0005386_behavior/neurological_phenoty1.14202132
79MP0002751_abnormal_autonomic_nervous1.14000767
80MP0002277_abnormal_respiratory_mucosa1.13254231
81MP0002938_white_spotting1.09413247
82MP0002160_abnormal_reproductive_system1.08942999
83MP0002882_abnormal_neuron_morphology1.07523860
84MP0008995_early_reproductive_senescence1.06277844
85MP0003938_abnormal_ear_development1.06099956
86MP0008875_abnormal_xenobiotic_pharmacok1.05312528
87MP0008961_abnormal_basal_metabolism1.04908640
88MP0002752_abnormal_somatic_nervous1.02940293
89MP0003890_abnormal_embryonic-extraembry1.02894649
90MP0002234_abnormal_pharynx_morphology1.02421651
91MP0003646_muscle_fatigue1.01737379
92MP0001919_abnormal_reproductive_system0.96694921
93MP0004043_abnormal_pH_regulation0.95938847
94MP0002822_catalepsy0.95912769
95MP0005187_abnormal_penis_morphology0.95356048
96MP0008569_lethality_at_weaning0.92409456
97MP0004147_increased_porphyrin_level0.92067560
98MP0001324_abnormal_eye_pigmentation0.92010457
99MP0002229_neurodegeneration0.91820469
100MP0002066_abnormal_motor_capabilities/c0.91634946
101MP0002095_abnormal_skin_pigmentation0.91273808
102MP0001944_abnormal_pancreas_morphology0.87629093
103MP0000955_abnormal_spinal_cord0.87250049
104MP0004215_abnormal_myocardial_fiber0.84735018
105MP0001664_abnormal_digestion0.83817016
106MP0002148_abnormal_hypersensitivity_rea0.83444241
107MP0005075_abnormal_melanosome_morpholog0.83123686
108MP0000049_abnormal_middle_ear0.83108543
109MP0003634_abnormal_glial_cell0.82344933
110MP0003724_increased_susceptibility_to0.80851940
111MP0000647_abnormal_sebaceous_gland0.80806717
112MP0000566_synostosis0.78206474
113MP0003122_maternal_imprinting0.78097469
114MP0005671_abnormal_response_to0.78037033
115MP0005391_vision/eye_phenotype0.76144203
116MP0001293_anophthalmia0.75895738
117MP0005195_abnormal_posterior_eye0.74884039
118MP0004134_abnormal_chest_morphology0.71763190
119MP0004145_abnormal_muscle_electrophysio0.70169726
120MP0002009_preneoplasia0.69950922
121MP0004885_abnormal_endolymph0.69814815
122MP0003698_abnormal_male_reproductive0.69356838
123MP0002152_abnormal_brain_morphology0.67010921
124MP0002177_abnormal_outer_ear0.65054252
125MP0005408_hypopigmentation0.64141161
126MP0005084_abnormal_gallbladder_morpholo0.62866618
127MP0003183_abnormal_peptide_metabolism0.62257750
128MP0004811_abnormal_neuron_physiology0.61361502
129MP0002132_abnormal_respiratory_system0.60452077
130MP0002693_abnormal_pancreas_physiology0.60303159

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.71897635
2Mitochondrial inheritance (HP:0001427)4.23714492
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.15730670
4Progressive macrocephaly (HP:0004481)4.06686925
5Abnormal mitochondria in muscle tissue (HP:0008316)4.03118078
6Dynein arm defect of respiratory motile cilia (HP:0012255)3.88222404
7Absent/shortened dynein arms (HP:0200106)3.88222404
8Abnormal ciliary motility (HP:0012262)3.68700841
9Abnormal respiratory motile cilium morphology (HP:0005938)3.66284252
10Abnormal respiratory epithelium morphology (HP:0012253)3.66284252
11Acute encephalopathy (HP:0006846)3.65939190
12Abnormal respiratory motile cilium physiology (HP:0012261)3.64064361
13Increased hepatocellular lipid droplets (HP:0006565)3.63994370
14Renal Fanconi syndrome (HP:0001994)3.59306440
15Hepatocellular necrosis (HP:0001404)3.40366877
16Increased CSF lactate (HP:0002490)3.36818425
17Congenital stationary night blindness (HP:0007642)3.32081099
18Gait imbalance (HP:0002141)3.24796885
19* Medial flaring of the eyebrow (HP:0010747)3.19765512
20Hypothermia (HP:0002045)3.16947863
21Abnormality of the renal medulla (HP:0100957)3.11063631
22Optic disc pallor (HP:0000543)3.08804931
23Congenital primary aphakia (HP:0007707)3.05351498
24Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.04868591
25Nephrogenic diabetes insipidus (HP:0009806)3.03989777
26Abnormality of the renal cortex (HP:0011035)3.01640757
27Abnormal hair whorl (HP:0010721)2.99524977
283-Methylglutaconic aciduria (HP:0003535)2.96533535
29Lipid accumulation in hepatocytes (HP:0006561)2.94073676
30Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.87696733
31Retinal dysplasia (HP:0007973)2.81724161
32Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.79231841
33Parakeratosis (HP:0001036)2.75819616
34Focal motor seizures (HP:0011153)2.75529813
35Abnormality of renal resorption (HP:0011038)2.67453012
36Type II lissencephaly (HP:0007260)2.66298881
37Rhinitis (HP:0012384)2.63777111
38True hermaphroditism (HP:0010459)2.60438751
39Large for gestational age (HP:0001520)2.58964655
40Exertional dyspnea (HP:0002875)2.56527987
41Chronic hepatic failure (HP:0100626)2.53623719
42Hepatic necrosis (HP:0002605)2.50501440
43Pancreatic fibrosis (HP:0100732)2.46146005
44Intestinal atresia (HP:0011100)2.43655017
45Genital tract atresia (HP:0001827)2.43609830
46Cystic liver disease (HP:0006706)2.42089355
47Gaze-evoked nystagmus (HP:0000640)2.41390147
48Vaginal atresia (HP:0000148)2.41259221
49Leukodystrophy (HP:0002415)2.38869193
50Absent speech (HP:0001344)2.33451763
51Abnormal rod and cone electroretinograms (HP:0008323)2.31527668
52Renal cortical cysts (HP:0000803)2.30521946
53Tubulointerstitial nephritis (HP:0001970)2.30291167
54Polydipsia (HP:0001959)2.29702790
55Abnormal drinking behavior (HP:0030082)2.29702790
56Exercise intolerance (HP:0003546)2.28208013
57Febrile seizures (HP:0002373)2.27575615
58Epileptic encephalopathy (HP:0200134)2.27240434
59Attenuation of retinal blood vessels (HP:0007843)2.25348761
60Atonic seizures (HP:0010819)2.22953651
61Tubular atrophy (HP:0000092)2.16998370
62Hemiparesis (HP:0001269)2.16887788
63Abnormality of midbrain morphology (HP:0002418)2.15945842
64Molar tooth sign on MRI (HP:0002419)2.15945842
65Abnormality of glycolysis (HP:0004366)2.15821370
66Increased serum pyruvate (HP:0003542)2.15821370
67Aplasia/Hypoplasia of the lens (HP:0008063)2.15250514
68Abolished electroretinogram (ERG) (HP:0000550)2.12712200
69Patchy hypopigmentation of hair (HP:0011365)2.12421726
70Pancreatic cysts (HP:0001737)2.08725607
71Bony spicule pigmentary retinopathy (HP:0007737)2.08165448
72Respiratory failure (HP:0002878)2.07894127
73Poor coordination (HP:0002370)2.07086603
74Increased intramyocellular lipid droplets (HP:0012240)2.06612604
75Oligodactyly (hands) (HP:0001180)2.06297732
76Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.06199198
77Degeneration of the lateral corticospinal tracts (HP:0002314)2.06199198
78Increased serum lactate (HP:0002151)2.02680421
79Hyperventilation (HP:0002883)2.01820735
80Widely spaced teeth (HP:0000687)1.99810853
81Respiratory difficulties (HP:0002880)1.98558124
82Lactic acidosis (HP:0003128)1.98362330
83Furrowed tongue (HP:0000221)1.98045916
84Congenital hepatic fibrosis (HP:0002612)1.97036830
85Limb dystonia (HP:0002451)1.96896991
86Broad-based gait (HP:0002136)1.95427468
87Bile duct proliferation (HP:0001408)1.95194774
88Abnormal biliary tract physiology (HP:0012439)1.95194774
89Agitation (HP:0000713)1.91634128
90Dialeptic seizures (HP:0011146)1.91455109
91Aplasia/Hypoplasia of the tongue (HP:0010295)1.90915336
92Microvesicular hepatic steatosis (HP:0001414)1.89278258
93Inability to walk (HP:0002540)1.88676794
94Congenital, generalized hypertrichosis (HP:0004540)1.88041978
95Methylmalonic aciduria (HP:0012120)1.86555909
96* Postaxial hand polydactyly (HP:0001162)1.85688813
97Nephronophthisis (HP:0000090)1.85228815
98Focal seizures (HP:0007359)1.84387310
99Esotropia (HP:0000565)1.84015324
100Sensory axonal neuropathy (HP:0003390)1.83740460
101White forelock (HP:0002211)1.83694095
102Polyuria (HP:0000103)1.82927898
103Type I transferrin isoform profile (HP:0003642)1.81651178
104Abnormality of vitamin B metabolism (HP:0004340)1.80867305
105Postaxial foot polydactyly (HP:0001830)1.80609648
106Congenital sensorineural hearing impairment (HP:0008527)1.80563235
107Optic nerve hypoplasia (HP:0000609)1.80203034
108Myokymia (HP:0002411)1.79908866
109Narrow forehead (HP:0000341)1.79834481
110Progressive inability to walk (HP:0002505)1.79730987
111Limb hypertonia (HP:0002509)1.79155158
112Protruding tongue (HP:0010808)1.78840345
113Abnormality of the labia minora (HP:0012880)1.77475229
114Chronic bronchitis (HP:0004469)1.77407343
115Genetic anticipation (HP:0003743)1.77326752
116Ketosis (HP:0001946)1.77149260
117Neuroendocrine neoplasm (HP:0100634)1.76780299
118Volvulus (HP:0002580)1.75564936
119Pachygyria (HP:0001302)1.74361325
120X-linked dominant inheritance (HP:0001423)1.74302085
121Renal tubular dysfunction (HP:0000124)1.73775976
122Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.73540304
123Decreased activity of mitochondrial respiratory chain (HP:0008972)1.73540304
124Polyphagia (HP:0002591)1.73473736
125Aplasia/Hypoplasia of the sacrum (HP:0008517)1.72246041
126Pendular nystagmus (HP:0012043)1.72082296
127Cerebral edema (HP:0002181)1.70539538
128Absent rod-and cone-mediated responses on ERG (HP:0007688)1.70378973
129Fair hair (HP:0002286)1.67920442
130Nasolacrimal duct obstruction (HP:0000579)1.67782943
131Aplasia/hypoplasia of the uterus (HP:0008684)1.67128388
132Glycosuria (HP:0003076)1.66754666
133Preaxial hand polydactyly (HP:0001177)1.66517576
134Sclerocornea (HP:0000647)1.63874044
135Aganglionic megacolon (HP:0002251)1.63571353
136Congenital ichthyosiform erythroderma (HP:0007431)1.63458870
137Male pseudohermaphroditism (HP:0000037)1.60840276
138Abnormality of secondary sexual hair (HP:0009888)1.58759337
139Abnormality of the axillary hair (HP:0100134)1.58759337
140Methylmalonic acidemia (HP:0002912)1.56088216
141Anencephaly (HP:0002323)1.55492272
142Decreased central vision (HP:0007663)1.55234573
143Progressive cerebellar ataxia (HP:0002073)1.55140228
144Septate vagina (HP:0001153)1.54994771
145Asthma (HP:0002099)1.53459117
146Bronchiectasis (HP:0002110)1.53358937
147Pheochromocytoma (HP:0002666)1.53286871
148Lissencephaly (HP:0001339)1.53208716

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.55859450
2CASK4.22606247
3TNIK2.89883787
4STK162.83345369
5MAP4K22.40738097
6MAP3K122.26813135
7MARK12.12886980
8PINK12.09348855
9ACVR1B2.06699112
10STK392.03900152
11MAPK131.93786803
12MAP2K71.91041117
13OXSR11.88929757
14TAOK31.87358198
15PBK1.86267812
16CDK191.82186482
17IRAK41.78944017
18BMPR1B1.78684433
19TXK1.77335305
20BMPR21.71147248
21VRK11.67654096
22NME11.61715856
23GRK71.58006935
24MUSK1.56551467
25PRPF4B1.56014223
26ZAK1.55391498
27ADRBK21.54143090
28MST41.53931009
29INSRR1.47756935
30PAK31.46282544
31FGFR21.45624443
32TLK11.40125375
33BCR1.39759880
34TRIM281.39689216
35ARAF1.38382309
36PNCK1.38207323
37DYRK21.37366622
38IRAK31.35747487
39MKNK21.35244062
40IRAK21.34023491
41YES11.32627460
42PLK21.28121145
43NTRK31.24929980
44MAPK151.24304196
45UHMK11.22712198
46EPHA41.19485295
47BCKDK1.18329770
48CSNK1G31.10823597
49MKNK11.10639902
50CAMK2B1.10016823
51GRK51.07790060
52WNK41.07447043
53LIMK11.06922361
54NEK61.06833181
55PKN11.04336968
56CAMKK21.03949674
57MAPKAPK51.01312346
58IRAK11.01293853
59RIPK40.97357183
60BRAF0.96981868
61SRPK10.95006741
62EIF2AK10.89864018
63CSNK1A1L0.86668922
64CAMK2A0.86207753
65DYRK1A0.85937086
66FES0.82310719
67ERBB30.82209709
68TEC0.81365259
69CSNK1G20.80601997
70CSNK1G10.78624008
71TGFBR10.76958606
72NME20.75883880
73FGR0.75377149
74PRKCE0.75093818
75CLK10.74125180
76SIK30.73345577
77SGK4940.73191923
78SGK2230.73191923
79PHKG20.72921457
80PHKG10.72921457
81WNK30.72058340
82CDK30.71035976
83STK38L0.70564462
84CAMK2D0.69807189
85MINK10.67344214
86NTRK20.65331584
87NUAK10.63550845
88MAP3K140.63252634
89MAP2K60.62812884
90MYLK0.61884115
91MAP2K40.60805381
92CDK50.60244635
93ADRBK10.60176527
94STK110.58254091
95EIF2AK30.57657643
96EIF2AK20.57418295
97SGK20.57371969
98RPS6KA50.57283162
99BLK0.56913218
100NLK0.55302302
101GRK10.54942626
102PIK3CA0.54295771
103PIM20.54139803
104CAMK2G0.53495650
105ERBB20.52139582
106PASK0.51186265
107PRKCQ0.50562945
108MAP3K40.50103421
109PTK2B0.48846291
110SYK0.48358760
111IKBKB0.46903391
112HIPK20.46888117
113CAMK10.46270741
114PRKACA0.46084301
115EPHB20.44900187
116CCNB10.44477561
117CDK140.43641604
118AKT30.43608617
119PRKG10.43418596
120TNK20.43176350
121DAPK20.41919722
122CHUK0.41535406
123PRKCG0.41464378
124VRK20.41336868
125BRSK20.40535512
126PRKCH0.40373949
127STK30.40000627
128STK240.38483249
129CDK180.38306998
130ITK0.38217572
131SGK10.37548403
132CSNK1A10.37519054
133LYN0.37388901
134PLK30.36021050
135CSNK1D0.35833400
136DYRK30.34655512
137OBSCN0.34286365
138CDK11A0.33702006
139PRKCZ0.33577895
140FGFR10.32272660

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.67771086
2Parkinsons disease_Homo sapiens_hsa050123.79240037
3Protein export_Homo sapiens_hsa030603.52306007
4Alzheimers disease_Homo sapiens_hsa050103.12971408
5Huntingtons disease_Homo sapiens_hsa050162.91880420
6Ribosome_Homo sapiens_hsa030102.53750957
7Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.23974395
8Butanoate metabolism_Homo sapiens_hsa006502.22731992
9Collecting duct acid secretion_Homo sapiens_hsa049662.15874035
10Nicotine addiction_Homo sapiens_hsa050332.13728890
11Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.07733898
12Proteasome_Homo sapiens_hsa030501.95446407
13Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.94725000
14RNA polymerase_Homo sapiens_hsa030201.92159211
15Nitrogen metabolism_Homo sapiens_hsa009101.89594893
16SNARE interactions in vesicular transport_Homo sapiens_hsa041301.81437879
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.78404292
18Cardiac muscle contraction_Homo sapiens_hsa042601.72926811
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.72762634
20Phototransduction_Homo sapiens_hsa047441.70797546
21Tryptophan metabolism_Homo sapiens_hsa003801.69533196
22Propanoate metabolism_Homo sapiens_hsa006401.64614570
23Serotonergic synapse_Homo sapiens_hsa047261.55769894
24Vibrio cholerae infection_Homo sapiens_hsa051101.55503793
25Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.54102395
26Ether lipid metabolism_Homo sapiens_hsa005651.50235195
27Taste transduction_Homo sapiens_hsa047421.44663379
28Morphine addiction_Homo sapiens_hsa050321.43347986
29Rheumatoid arthritis_Homo sapiens_hsa053231.43336419
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.42263250
31Sphingolipid metabolism_Homo sapiens_hsa006001.33558910
32Synaptic vesicle cycle_Homo sapiens_hsa047211.33094162
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.28656515
34Glutamatergic synapse_Homo sapiens_hsa047241.27566301
35Caffeine metabolism_Homo sapiens_hsa002321.27352817
36Graft-versus-host disease_Homo sapiens_hsa053321.23576953
37Steroid biosynthesis_Homo sapiens_hsa001001.22306752
38GABAergic synapse_Homo sapiens_hsa047271.22246354
39Autoimmune thyroid disease_Homo sapiens_hsa053201.18599744
40Sulfur metabolism_Homo sapiens_hsa009201.17427114
41Selenocompound metabolism_Homo sapiens_hsa004501.13305558
42Circadian entrainment_Homo sapiens_hsa047131.13049984
43Allograft rejection_Homo sapiens_hsa053301.11697200
44Olfactory transduction_Homo sapiens_hsa047401.10314893
45Basal transcription factors_Homo sapiens_hsa030221.10291778
46Peroxisome_Homo sapiens_hsa041461.05881098
47Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.01518164
48Primary bile acid biosynthesis_Homo sapiens_hsa001201.00475675
49Circadian rhythm_Homo sapiens_hsa047101.00409114
50Amphetamine addiction_Homo sapiens_hsa050310.98854946
51Chemical carcinogenesis_Homo sapiens_hsa052040.97343680
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.97011685
53Fatty acid elongation_Homo sapiens_hsa000620.96768427
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.95592018
55Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.91834565
56Dopaminergic synapse_Homo sapiens_hsa047280.91749031
57Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.91565704
58Long-term depression_Homo sapiens_hsa047300.89876168
59Purine metabolism_Homo sapiens_hsa002300.87448087
60Asthma_Homo sapiens_hsa053100.86899546
61Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.86782753
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85922966
63Steroid hormone biosynthesis_Homo sapiens_hsa001400.84114441
64Pyrimidine metabolism_Homo sapiens_hsa002400.83433805
65Cocaine addiction_Homo sapiens_hsa050300.82589733
66Histidine metabolism_Homo sapiens_hsa003400.81583144
67Phagosome_Homo sapiens_hsa041450.81340503
68Dorso-ventral axis formation_Homo sapiens_hsa043200.81281997
69ABC transporters_Homo sapiens_hsa020100.80550118
70Axon guidance_Homo sapiens_hsa043600.78909286
71Arachidonic acid metabolism_Homo sapiens_hsa005900.77113354
72Retinol metabolism_Homo sapiens_hsa008300.76179550
73Type I diabetes mellitus_Homo sapiens_hsa049400.75833433
74Cholinergic synapse_Homo sapiens_hsa047250.75223302
75beta-Alanine metabolism_Homo sapiens_hsa004100.72425788
76Long-term potentiation_Homo sapiens_hsa047200.72067749
77Hedgehog signaling pathway_Homo sapiens_hsa043400.71529016
78Regulation of autophagy_Homo sapiens_hsa041400.69996602
79Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.69979131
80Insulin secretion_Homo sapiens_hsa049110.68333600
81Hematopoietic cell lineage_Homo sapiens_hsa046400.67162335
82Renin secretion_Homo sapiens_hsa049240.66715482
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.66588408
84Primary immunodeficiency_Homo sapiens_hsa053400.65170306
85Intestinal immune network for IgA production_Homo sapiens_hsa046720.63856172
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.62651810
87Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.61336063
88Maturity onset diabetes of the young_Homo sapiens_hsa049500.61090672
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59870277
90Calcium signaling pathway_Homo sapiens_hsa040200.58591575
91Alcoholism_Homo sapiens_hsa050340.57394162
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57382423
93Ovarian steroidogenesis_Homo sapiens_hsa049130.56871964
94Fanconi anemia pathway_Homo sapiens_hsa034600.54151892
95Non-homologous end-joining_Homo sapiens_hsa034500.53992005
96Linoleic acid metabolism_Homo sapiens_hsa005910.53838904
97Nucleotide excision repair_Homo sapiens_hsa034200.53274971
98Salivary secretion_Homo sapiens_hsa049700.52006587
99Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52003365
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.51532795
101Spliceosome_Homo sapiens_hsa030400.51355302
102Gastric acid secretion_Homo sapiens_hsa049710.50998032
103Homologous recombination_Homo sapiens_hsa034400.50677765
104RNA degradation_Homo sapiens_hsa030180.50425334
105Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.49574669
106Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48786942
107Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.48070132
108Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.45646204
109Fatty acid degradation_Homo sapiens_hsa000710.45172506
110Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44231516
111Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43499706
112Mineral absorption_Homo sapiens_hsa049780.42248188
113Glycerolipid metabolism_Homo sapiens_hsa005610.42200654
114Metabolic pathways_Homo sapiens_hsa011000.41791585
115Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36817831
116Sphingolipid signaling pathway_Homo sapiens_hsa040710.35410286
117Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.34877100
118Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34841758
119Vascular smooth muscle contraction_Homo sapiens_hsa042700.34661180
120Oxytocin signaling pathway_Homo sapiens_hsa049210.34490296
121African trypanosomiasis_Homo sapiens_hsa051430.33842775
122cAMP signaling pathway_Homo sapiens_hsa040240.33708389
123Pancreatic secretion_Homo sapiens_hsa049720.32640474
124Ras signaling pathway_Homo sapiens_hsa040140.32205299
125Type II diabetes mellitus_Homo sapiens_hsa049300.30401816
126Basal cell carcinoma_Homo sapiens_hsa052170.30361199
127Malaria_Homo sapiens_hsa051440.29936443
128Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.29826770
129T cell receptor signaling pathway_Homo sapiens_hsa046600.29358354
130Other glycan degradation_Homo sapiens_hsa005110.29148476
131alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28680852
132Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.27737901
133Melanogenesis_Homo sapiens_hsa049160.25469393
134Sulfur relay system_Homo sapiens_hsa041220.23727597
135Pertussis_Homo sapiens_hsa051330.23664143

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