BAZ1A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The BAZ1A gene encodes the accessory subunit of the ATP-dependent chromatin assembly factor (ACF), a member of the ISWI ('imitation switch') family of chromatin remodeling complexes (summarized by Racki et al., 2009 [PubMed 20033039]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)3.98873428
2positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.78439219
3macrophage activation involved in immune response (GO:0002281)3.65453471
4protein localization to kinetochore (GO:0034501)3.64139483
5nuclear pore organization (GO:0006999)3.57826596
6protein localization to chromosome, centromeric region (GO:0071459)3.53978383
7positive regulation of gamma-delta T cell activation (GO:0046645)3.53243083
8detection of molecule of bacterial origin (GO:0032490)3.52577955
9mitotic sister chromatid cohesion (GO:0007064)3.44880760
10regulation of interferon-alpha production (GO:0032647)3.43886721
11positive regulation of interferon-alpha production (GO:0032727)3.41548502
12negative regulation of cell killing (GO:0031342)3.38059020
13negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.38059020
14regulation of interferon-beta biosynthetic process (GO:0045357)3.37161197
15pore complex assembly (GO:0046931)3.32200639
16neutrophil mediated immunity (GO:0002446)3.29777256
17positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.27756593
18positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.23987751
19detection of other organism (GO:0098543)3.21878366
20positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.16867423
21defense response to protozoan (GO:0042832)3.15154353
22lipopolysaccharide-mediated signaling pathway (GO:0031663)3.12741201
23cellular response to type I interferon (GO:0071357)3.08818645
24type I interferon signaling pathway (GO:0060337)3.08818645
25response to type I interferon (GO:0034340)3.05809444
26mitotic metaphase plate congression (GO:0007080)3.04052364
27mitotic nuclear envelope disassembly (GO:0007077)3.02772399
28regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.01138767
29detection of external biotic stimulus (GO:0098581)3.01025692
30leukocyte aggregation (GO:0070486)3.00237133
31microglial cell activation (GO:0001774)2.99708970
32regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.97212907
33DNA replication checkpoint (GO:0000076)2.97189145
34kinetochore organization (GO:0051383)2.94225270
35neutrophil activation (GO:0042119)2.93582659
36mitotic chromosome condensation (GO:0007076)2.92777112
37negative regulation of T cell mediated immunity (GO:0002710)2.91961641
38positive regulation of interferon-beta production (GO:0032728)2.91449076
39regulation of spindle organization (GO:0090224)2.90608381
40response to host immune response (GO:0052572)2.90174374
41response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.90174374
42myeloid cell activation involved in immune response (GO:0002275)2.89144562
43antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.89050526
44antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.89050526
45antigen processing and presentation of endogenous antigen (GO:0019883)2.88831179
46T cell migration (GO:0072678)2.88569664
47meiotic chromosome segregation (GO:0045132)2.85737071
48myeloid leukocyte mediated immunity (GO:0002444)2.82882946
49detection of bacterium (GO:0016045)2.81922500
50granulocyte activation (GO:0036230)2.80737209
51germinal center formation (GO:0002467)2.80181273
52membrane disassembly (GO:0030397)2.79583161
53nuclear envelope disassembly (GO:0051081)2.79583161
54DNA unwinding involved in DNA replication (GO:0006268)2.78888225
55macrophage activation (GO:0042116)2.78320594
56antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.78156419
57positive regulation of chromosome segregation (GO:0051984)2.76125543
58negative regulation of phagocytosis (GO:0050765)2.75161237
59regulation of alpha-beta T cell proliferation (GO:0046640)2.74646207
60Arp2/3 complex-mediated actin nucleation (GO:0034314)2.74475720
61response to interleukin-15 (GO:0070672)2.74127143
62positive regulation of B cell differentiation (GO:0045579)2.73307109
63interferon-gamma-mediated signaling pathway (GO:0060333)2.72994982
64histone H3-K36 demethylation (GO:0070544)2.71521133
65production of molecular mediator involved in inflammatory response (GO:0002532)2.70943422
66response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.70794844
67response to host (GO:0075136)2.70794844
68response to host defenses (GO:0052200)2.70794844
69DNA strand elongation involved in DNA replication (GO:0006271)2.70445176
70regulation of DNA endoreduplication (GO:0032875)2.69832997
71detection of biotic stimulus (GO:0009595)2.69304759
72positive regulation of alpha-beta T cell proliferation (GO:0046641)2.68418336
73regulation of interleukin-12 biosynthetic process (GO:0045075)2.68054366
74DNA replication initiation (GO:0006270)2.66861214
75monoubiquitinated protein deubiquitination (GO:0035520)2.65867760
76metaphase plate congression (GO:0051310)2.63982374
77regulation of vitamin D biosynthetic process (GO:0060556)2.63380406
78regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.63358162
79regulation of B cell receptor signaling pathway (GO:0050855)2.63245909
80sister chromatid segregation (GO:0000819)2.63162710
81interferon-gamma production (GO:0032609)2.63145682
82regulation of RNA export from nucleus (GO:0046831)2.61710326
83regulation of interleukin-8 biosynthetic process (GO:0045414)2.61016451
84immunoglobulin mediated immune response (GO:0016064)2.59855418
85DNA strand elongation (GO:0022616)2.59833453
86mitotic sister chromatid segregation (GO:0000070)2.59659033
87regulation of interferon-beta production (GO:0032648)2.59320071
88negative regulation of B cell proliferation (GO:0030889)2.58994997
89positive regulation of mitotic sister chromatid separation (GO:1901970)2.58901811
90positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.58901811
91positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.58901811
92regulation of histone H3-K9 methylation (GO:0051570)2.58002122
93regulation of mitotic spindle organization (GO:0060236)2.57664089
94telomere maintenance via recombination (GO:0000722)2.57643242
95establishment of chromosome localization (GO:0051303)2.56976873
96positive thymic T cell selection (GO:0045059)2.56361726
97negative regulation of interleukin-12 production (GO:0032695)2.55921967
98hepatocyte apoptotic process (GO:0097284)2.55917321
99mitotic recombination (GO:0006312)2.55858415
100natural killer cell mediated immunity (GO:0002228)2.55404207
101natural killer cell mediated cytotoxicity (GO:0042267)2.55404207
102response to peptidoglycan (GO:0032494)2.55401934
103regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.54002017
104regulation of B cell differentiation (GO:0045577)2.53860614
105positive regulation of granulocyte differentiation (GO:0030854)2.53814709
106protein localization to chromosome (GO:0034502)2.53389713
107NIK/NF-kappaB signaling (GO:0038061)2.53324580
108telomere maintenance via semi-conservative replication (GO:0032201)2.53081095
109regulation of tolerance induction (GO:0002643)2.51927780
110histone H3-K4 trimethylation (GO:0080182)2.51507579
111B cell proliferation (GO:0042100)2.50754123
112necroptotic process (GO:0070266)2.49796944
113tolerance induction (GO:0002507)2.47543694
114regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.47062695
115regulation of gamma-delta T cell differentiation (GO:0045586)2.46062995
116positive regulation of isotype switching (GO:0045830)2.45229254
117regulation of interleukin-12 production (GO:0032655)2.44844023
118regulation of gamma-delta T cell activation (GO:0046643)2.44777046
1193-UTR-mediated mRNA stabilization (GO:0070935)2.44770904
120translesion synthesis (GO:0019985)2.44379860
121negative regulation of lymphocyte mediated immunity (GO:0002707)2.43739966
122positive regulation of toll-like receptor signaling pathway (GO:0034123)2.43699859
123T-helper 1 type immune response (GO:0042088)2.43682715
124DNA topological change (GO:0006265)2.43525634
125negative regulation of growth of symbiont in host (GO:0044130)2.43498234
126negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.43498234
127regulation of growth of symbiont in host (GO:0044126)2.43498234
128attachment of spindle microtubules to kinetochore (GO:0008608)2.35891725
129negative thymic T cell selection (GO:0045060)2.35497798
130cellular extravasation (GO:0045123)2.35234064
131myeloid dendritic cell activation (GO:0001773)2.33808707
132modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.33522082
133positive regulation by organism of defense response of other organism involved in symbiotic interact2.33522082
134modulation by symbiont of host immune response (GO:0052553)2.33522082
135positive regulation by symbiont of host defense response (GO:0052509)2.33522082
136modulation by symbiont of host defense response (GO:0052031)2.33522082
137modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.33522082
138negative T cell selection (GO:0043383)2.32926453
139regulation of necroptotic process (GO:0060544)2.32841574
140DNA replication-independent nucleosome assembly (GO:0006336)2.32630095
141DNA replication-independent nucleosome organization (GO:0034724)2.32630095
142B cell receptor signaling pathway (GO:0050853)2.31895677
143response to muramyl dipeptide (GO:0032495)2.31703727
144ribosomal small subunit assembly (GO:0000028)2.31544359
145CENP-A containing nucleosome assembly (GO:0034080)2.30880759
146chromatin remodeling at centromere (GO:0031055)2.30848071
147positive regulation of protein import into nucleus, translocation (GO:0033160)2.30704270
148kinetochore assembly (GO:0051382)2.29779852
149B cell mediated immunity (GO:0019724)2.29736788
150dosage compensation (GO:0007549)2.29452782
151response to protozoan (GO:0001562)2.29168029
152DNA duplex unwinding (GO:0032508)2.28644099
153nuclear envelope organization (GO:0006998)2.28630428
154neutrophil activation involved in immune response (GO:0002283)2.27418314
155DNA geometric change (GO:0032392)2.27272261
156negative regulation of histone methylation (GO:0031061)2.26328673
157positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.25539412
158negative regulation of DNA-dependent DNA replication (GO:2000104)2.24919598
159respiratory burst (GO:0045730)2.24501569
160regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.22629902
161chromatin assembly or disassembly (GO:0006333)2.22346970

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.66655759
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.60469406
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.55538673
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.43070964
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.90382451
6IRF8_22096565_ChIP-ChIP_GC-B_Human2.85195349
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.80074954
8IRF8_21731497_ChIP-ChIP_J774_Mouse2.65990044
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.43516699
10* MYC_22102868_ChIP-Seq_BL_Human2.39569240
11* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.36004705
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.35303799
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.32487754
14SMAD_19615063_ChIP-ChIP_OVARY_Human2.23946219
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.22981090
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.18428297
17GATA1_22025678_ChIP-Seq_K562_Human2.10918536
18* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.10695612
19* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.09752145
20ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.07929273
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.98768006
22BP1_19119308_ChIP-ChIP_Hs578T_Human1.96541049
23* VDR_21846776_ChIP-Seq_THP-1_Human1.96406572
24STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.95534895
25E2F1_21310950_ChIP-Seq_MCF-7_Human1.94557779
26MYB_26560356_Chip-Seq_TH2_Human1.91625574
27IRF8_27001747_Chip-Seq_BMDM_Mouse1.89418882
28SPI1_23547873_ChIP-Seq_NB4_Human1.89275869
29MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.85981812
30SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.85184266
31STAT4_19710469_ChIP-ChIP_TH1__Mouse1.85149421
32NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.84962901
33* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.83505762
34* MYB_26560356_Chip-Seq_TH1_Human1.79837565
35BRD4_27068464_Chip-Seq_AML-cells_Mouse1.76162232
36AR_21909140_ChIP-Seq_LNCAP_Human1.75968655
37IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.66887197
38VDR_24787735_ChIP-Seq_THP-1_Human1.66259130
39* MAF_26560356_Chip-Seq_TH1_Human1.64965117
40VDR_23849224_ChIP-Seq_CD4+_Human1.63437239
41FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.62030601
42ELF1_17652178_ChIP-ChIP_JURKAT_Human1.61012276
43MYC_19079543_ChIP-ChIP_MESCs_Mouse1.59980651
44SCL_19346495_ChIP-Seq_HPC-7_Human1.54278822
45TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.51144272
46NOTCH1_21737748_ChIP-Seq_TLL_Human1.50801744
47* UTX_26944678_Chip-Seq_JUKART_Human1.49632969
48GATA3_26560356_Chip-Seq_TH2_Human1.49414601
49SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.49051436
50MYC_19030024_ChIP-ChIP_MESCs_Mouse1.48332235
51RUNX1_22412390_ChIP-Seq_EML_Mouse1.46300338
52KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.43455305
53* VDR_24763502_ChIP-Seq_THP-1_Human1.43273304
54ELK1_19687146_ChIP-ChIP_HELA_Human1.42121712
55FOXP3_21729870_ChIP-Seq_TREG_Human1.40709016
56HOXB4_20404135_ChIP-ChIP_EML_Mouse1.39755773
57CIITA_25753668_ChIP-Seq_RAJI_Human1.39165347
58FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.37503832
59EST1_17652178_ChIP-ChIP_JURKAT_Human1.36538382
60NELFA_20434984_ChIP-Seq_ESCs_Mouse1.35471306
61SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.32964549
62CREB1_15753290_ChIP-ChIP_HEK293T_Human1.30829482
63* TCF7_22412390_ChIP-Seq_EML_Mouse1.30026495
64MYC_18358816_ChIP-ChIP_MESCs_Mouse1.28261079
65GABP_17652178_ChIP-ChIP_JURKAT_Human1.27896025
66XRN2_22483619_ChIP-Seq_HELA_Human1.27562685
67CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.27419052
68KDM5A_27292631_Chip-Seq_BREAST_Human1.27021779
69SALL1_21062744_ChIP-ChIP_HESCs_Human1.26882060
70TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.26220189
71KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.20159666
72GATA2_22383799_ChIP-Seq_G1ME_Mouse1.19825437
73ETS1_20019798_ChIP-Seq_JURKAT_Human1.19200100
74RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.18355927
75ERG_20887958_ChIP-Seq_HPC-7_Mouse1.17254684
76BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.16250216
77MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.15998253
78MYCN_18555785_ChIP-Seq_MESCs_Mouse1.13555105
79MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.13505654
80PU_27001747_Chip-Seq_BMDM_Mouse1.12361368
81PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11861831
82RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.11371063
83* MAF_26560356_Chip-Seq_TH2_Human1.10652697
84RUNX_20019798_ChIP-Seq_JUKART_Human1.10540092
85NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.08216332
86FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.07567074
87VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.07072387
88STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.05894415
89PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05189772
90TFEB_21752829_ChIP-Seq_HELA_Human1.05045875
91NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.03166555
92DCP1A_22483619_ChIP-Seq_HELA_Human1.02584359
93GATA3_27048872_Chip-Seq_THYMUS_Human1.00368042
94GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.00199753
95FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.98869227
96* TP63_19390658_ChIP-ChIP_HaCaT_Human0.98639326
97PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98255845
98* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.97924993
99* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.97736450
100TTF2_22483619_ChIP-Seq_HELA_Human0.96518510
101RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.96077712
102TP63_17297297_ChIP-ChIP_HaCaT_Human0.95808372
103* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.95711784
104E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.94843069
105* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.94232203
106* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.94101366
107GABP_19822575_ChIP-Seq_HepG2_Human0.94042603
108STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.93688155
109MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.92220758
110SPI1_23127762_ChIP-Seq_K562_Human0.91785523
111JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.91117401
112PADI4_21655091_ChIP-ChIP_MCF-7_Human0.88719736
113CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86909733
114NANOG_18555785_ChIP-Seq_MESCs_Mouse0.86467525
115POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.85375912
116* NCOR1_26117541_ChIP-Seq_K562_Human0.85243606
117CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81044481
118STAT6_21828071_ChIP-Seq_BEAS2B_Human0.80566935
119SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.77840158
120SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.77840158
121GATA1_19941827_ChIP-Seq_MEL86_Mouse0.77541886
122* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.77279215
123* KDM2B_26808549_Chip-Seq_DND41_Human0.76674524
124GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76210465
125GATA2_21666600_ChIP-Seq_HMVEC_Human0.73167418
126GATA1_19941827_ChIP-Seq_MEL_Mouse0.72666809
127PKCTHETA_26484144_Chip-Seq_BREAST_Human0.72230951

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.30872609
2MP0001835_abnormal_antigen_presentation3.03114810
3MP0008057_abnormal_DNA_replication2.97748322
4MP0003303_peritoneal_inflammation2.82945528
5MP0010094_abnormal_chromosome_stability2.76232299
6MP0002396_abnormal_hematopoietic_system2.73796319
7MP0003111_abnormal_nucleus_morphology2.59852885
8MP0001800_abnormal_humoral_immune2.41861312
9MP0005671_abnormal_response_to2.33276274
10MP0003077_abnormal_cell_cycle2.32913849
11MP0003436_decreased_susceptibility_to2.30201331
12MP0002452_abnormal_antigen_presenting2.16301839
13MP0003763_abnormal_thymus_physiology2.14982148
14MP0001790_abnormal_immune_system2.09674869
15MP0005387_immune_system_phenotype2.09674869
16MP0005000_abnormal_immune_tolerance2.07849462
17MP0000685_abnormal_immune_system2.05125697
18MP0004808_abnormal_hematopoietic_stem2.03921024
19MP0002398_abnormal_bone_marrow2.01341104
20MP0004957_abnormal_blastocyst_morpholog2.00712293
21MP0010307_abnormal_tumor_latency1.99358982
22MP0002723_abnormal_immune_serum1.99300226
23MP0009785_altered_susceptibility_to1.98574717
24MP0002420_abnormal_adaptive_immunity1.96542645
25MP0001819_abnormal_immune_cell1.95396835
26MP0010352_gastrointestinal_tract_polyps1.93649706
27MP0003656_abnormal_erythrocyte_physiolo1.92190046
28MP0005397_hematopoietic_system_phenotyp1.89479356
29MP0001545_abnormal_hematopoietic_system1.89479356
30MP0003300_gastrointestinal_ulcer1.87869894
31MP0009333_abnormal_splenocyte_physiolog1.87015352
32MP0005025_abnormal_response_to1.85685786
33MP0008058_abnormal_DNA_repair1.85418707
34MP0002419_abnormal_innate_immunity1.85106314
35MP0002166_altered_tumor_susceptibility1.85002611
36MP0005076_abnormal_cell_differentiation1.79861175
37MP0005451_abnormal_body_composition1.78806098
38MP0002405_respiratory_system_inflammati1.75036466
39MP0000716_abnormal_immune_system1.73741184
40MP0002006_tumorigenesis1.71244058
41MP0000490_abnormal_crypts_of1.71179150
42MP0002148_abnormal_hypersensitivity_rea1.67916569
43MP0000689_abnormal_spleen_morphology1.66307907
44MP0002722_abnormal_immune_system1.65186038
45MP0008007_abnormal_cellular_replicative1.64382224
46MP0004381_abnormal_hair_follicle1.60208514
47MP0001873_stomach_inflammation1.57990847
48MP0001853_heart_inflammation1.53923886
49MP0002429_abnormal_blood_cell1.53262197
50MP0000703_abnormal_thymus_morphology1.51428620
51MP0010155_abnormal_intestine_physiology1.50593284
52MP0005464_abnormal_platelet_physiology1.50186589
53MP0004947_skin_inflammation1.43815714
54MP0009278_abnormal_bone_marrow1.43331700
55MP0008877_abnormal_DNA_methylation1.36384684
56MP0008260_abnormal_autophagy1.34816263
57MP0009764_decreased_sensitivity_to1.34097441
58MP0000350_abnormal_cell_proliferation1.31160246
59MP0001845_abnormal_inflammatory_respons1.30793679
60MP0002019_abnormal_tumor_incidence1.30245601
61MP0003448_altered_tumor_morphology1.28722636
62MP0000569_abnormal_digit_pigmentation1.25994468
63MP0000858_altered_metastatic_potential1.25835212
64MP0003724_increased_susceptibility_to1.19862522
65MP0001730_embryonic_growth_arrest1.19759661
66MP0003172_abnormal_lysosome_physiology1.15887967
67MP0005174_abnormal_tail_pigmentation1.14808937
68MP0006082_CNS_inflammation1.13423602
69MP0000465_gastrointestinal_hemorrhage1.12995208
70MP0003566_abnormal_cell_adhesion1.11953614
71MP0003191_abnormal_cellular_cholesterol1.11628826
72MP0004185_abnormal_adipocyte_glucose1.09775492
73MP0005075_abnormal_melanosome_morpholog1.05076176
74MP0003221_abnormal_cardiomyocyte_apopto1.01616351
75MP0000313_abnormal_cell_death1.01579781
76MP0001533_abnormal_skeleton_physiology1.01527476
77MP0008932_abnormal_embryonic_tissue1.00326222
78MP0004264_abnormal_extraembryonic_tissu0.97269262
79MP0004883_abnormal_blood_vessel0.96263023
80MP0003183_abnormal_peptide_metabolism0.94933131
81MP0001672_abnormal_embryogenesis/_devel0.94001278
82MP0005380_embryogenesis_phenotype0.94001278
83MP0003786_premature_aging0.93236140
84MP0003984_embryonic_growth_retardation0.93119434
85MP0005164_abnormal_response_to0.93099862
86MP0002088_abnormal_embryonic_growth/wei0.91377331
87MP0005310_abnormal_salivary_gland0.88629275
88MP0003866_abnormal_defecation0.88474003
89MP0002086_abnormal_extraembryonic_tissu0.86670814
90MP0008469_abnormal_protein_level0.86023156
91MP0004510_myositis0.85954794
92MP0003828_pulmonary_edema0.85642431
93MP0003453_abnormal_keratinocyte_physiol0.83511093
94MP0005023_abnormal_wound_healing0.83164252
95MP0008004_abnormal_stomach_pH0.80315267
96MP0002877_abnormal_melanocyte_morpholog0.79930104
97MP0002998_abnormal_bone_remodeling0.79924240
98MP0001851_eye_inflammation0.79256357
99MP0001697_abnormal_embryo_size0.78572401
100MP0002080_prenatal_lethality0.76792510
101MP0003091_abnormal_cell_migration0.76475330
102MP0001216_abnormal_epidermal_layer0.76233315
103MP0002009_preneoplasia0.75828978
104MP0002095_abnormal_skin_pigmentation0.75527844
105MP0009763_increased_sensitivity_to0.75205364
106MP0002933_joint_inflammation0.74397477
107MP0010234_abnormal_vibrissa_follicle0.73652466
108MP0000015_abnormal_ear_pigmentation0.73615647
109MP0006054_spinal_hemorrhage0.72714172
110MP0005058_abnormal_lysosome_morphology0.71609530
111MP0005621_abnormal_cell_physiology0.69550985
112MP0002332_abnormal_exercise_endurance0.68341383
113MP0009765_abnormal_xenobiotic_induced0.67815979
114MP0000627_abnormal_mammary_gland0.67753996
115MP0000733_abnormal_muscle_development0.64941257
116MP0004197_abnormal_fetal_growth/weight/0.62983876
117MP0003705_abnormal_hypodermis_morpholog0.62915732
118MP0009931_abnormal_skin_appearance0.60297975
119MP0000377_abnormal_hair_follicle0.59378539
120MP0000383_abnormal_hair_follicle0.58989382
121MP0000371_diluted_coat_color0.58839587
122MP0002132_abnormal_respiratory_system0.58803131

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.13623605
2Recurrent abscess formation (HP:0002722)4.08664061
3Recurrent bacterial skin infections (HP:0005406)3.77326650
4Recurrent viral infections (HP:0004429)3.63561804
5Recurrent fungal infections (HP:0002841)3.57384496
6Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.55718262
7Obstructive lung disease (HP:0006536)3.41341343
8Chronic obstructive pulmonary disease (HP:0006510)3.41341343
9IgM deficiency (HP:0002850)3.22094909
10Chromsome breakage (HP:0040012)3.21498171
11Keratoconjunctivitis (HP:0001096)3.17193209
12Myositis (HP:0100614)3.13447632
13Thrombocytosis (HP:0001894)3.12795492
14Mediastinal lymphadenopathy (HP:0100721)3.07798116
15Cellulitis (HP:0100658)3.01948169
16Abnormality of the fingertips (HP:0001211)2.96461329
17Autoimmune hemolytic anemia (HP:0001890)2.95348522
18Recurrent bronchitis (HP:0002837)2.90582543
19Meningitis (HP:0001287)2.88006491
20Chromosomal breakage induced by crosslinking agents (HP:0003221)2.86254535
21Retrobulbar optic neuritis (HP:0100654)2.74034183
22Optic neuritis (HP:0100653)2.74034183
23Vasculitis (HP:0002633)2.72999757
24Pustule (HP:0200039)2.70182215
25Chronic mucocutaneous candidiasis (HP:0002728)2.70056699
26Recurrent cutaneous fungal infections (HP:0011370)2.70056699
27Abnormality of B cell number (HP:0010975)2.68840025
28B lymphocytopenia (HP:0010976)2.68840025
29Abnormality of the prostate (HP:0008775)2.64717484
30Recurrent gram-negative bacterial infections (HP:0005420)2.62360257
31Elevated erythrocyte sedimentation rate (HP:0003565)2.61452636
32T lymphocytopenia (HP:0005403)2.61050021
33Acute myeloid leukemia (HP:0004808)2.60003453
34Recurrent skin infections (HP:0001581)2.59538849
35Abnormality of T cells (HP:0002843)2.58171278
36Orchitis (HP:0100796)2.56907844
37Gangrene (HP:0100758)2.56863667
38Autoimmune thrombocytopenia (HP:0001973)2.55855517
39Eosinophilia (HP:0001880)2.54649893
40Abnormality of T cell number (HP:0011839)2.53404407
41Entropion (HP:0000621)2.52330854
42Abnormality of chromosome stability (HP:0003220)2.51472482
43Abnormality of T cell physiology (HP:0011840)2.50265829
44Chronic otitis media (HP:0000389)2.49243704
45Gingival bleeding (HP:0000225)2.44911420
46Abnormal delayed hypersensitivity skin test (HP:0002963)2.43660133
47Reticulocytopenia (HP:0001896)2.41939409
48Papillary thyroid carcinoma (HP:0002895)2.37458804
49Lymphopenia (HP:0001888)2.35723800
50IgG deficiency (HP:0004315)2.34905412
51Abnormality of cells of the lymphoid lineage (HP:0012140)2.33921727
52Agammaglobulinemia (HP:0004432)2.33683722
53Prominent nose (HP:0000448)2.33324250
54Lymphoma (HP:0002665)2.32564371
55Periodontitis (HP:0000704)2.31902661
56Nasal polyposis (HP:0100582)2.31580602
57Leukocytosis (HP:0001974)2.31123829
58IgA deficiency (HP:0002720)2.30621416
59Myelodysplasia (HP:0002863)2.30150985
60Pulmonary infiltrates (HP:0002113)2.29886378
61Prolonged bleeding time (HP:0003010)2.28483380
62Recurrent sinusitis (HP:0011108)2.27545673
63Panhypogammaglobulinemia (HP:0003139)2.26903090
64Birth length less than 3rd percentile (HP:0003561)2.26246767
65Granulocytopenia (HP:0001913)2.26125959
66Arterial thrombosis (HP:0004420)2.24132782
67Urticaria (HP:0001025)2.24073675
68Gingivitis (HP:0000230)2.24002153
69Osteomyelitis (HP:0002754)2.23673697
70Subacute progressive viral hepatitis (HP:0006572)2.23557920
71Osteolytic defects of the phalanges of the hand (HP:0009771)2.23099617
72Osteolytic defects of the hand bones (HP:0009699)2.23099617
73Ectopic kidney (HP:0000086)2.21415650
74Viral hepatitis (HP:0006562)2.20686536
75Stomatitis (HP:0010280)2.17815433
76Volvulus (HP:0002580)2.17459649
77Thyroiditis (HP:0100646)2.17047219
78Epistaxis (HP:0000421)2.16768983
79Abnormality of macrophages (HP:0004311)2.16721672
80Petechiae (HP:0000967)2.15761271
81Amaurosis fugax (HP:0100576)2.15295956
82Spinal cord lesions (HP:0100561)2.14363005
83Syringomyelia (HP:0003396)2.14363005
84Hemoptysis (HP:0002105)2.12829441
85Deep philtrum (HP:0002002)2.12644963
86Leukopenia (HP:0001882)2.12619337
87Abnormality of eosinophils (HP:0001879)2.12074188
88Pulmonary fibrosis (HP:0002206)2.11368157
89Inflammation of the large intestine (HP:0002037)2.11310404
90Abnormality of the preputium (HP:0100587)2.10541965
91Encephalitis (HP:0002383)2.10209005
92Recurrent pneumonia (HP:0006532)2.08260223
93Colitis (HP:0002583)2.07134835
94Abnormality of the pleura (HP:0002103)2.05509786
95Combined immunodeficiency (HP:0005387)2.05320974
96Gastrointestinal inflammation (HP:0004386)2.03805571
97Abnormality of the peritoneum (HP:0002585)2.01366706
98Facial hemangioma (HP:0000329)2.00353246
99Aplasia/Hypoplasia of the thymus (HP:0010515)1.99471830
100Clubbing of toes (HP:0100760)1.99207392
101Gastrointestinal infarctions (HP:0005244)1.98682870
102Anorexia (HP:0002039)1.98459348
103Increased IgM level (HP:0003496)1.98425908
104Slow saccadic eye movements (HP:0000514)1.97705270
105Severe combined immunodeficiency (HP:0004430)1.96758666
106Keratoconjunctivitis sicca (HP:0001097)1.96685291
107Increased IgE level (HP:0003212)1.96599871
108Cutaneous melanoma (HP:0012056)1.95587364
109Glomerulopathy (HP:0100820)1.95440540
110Skin ulcer (HP:0200042)1.95310611
111Prostate neoplasm (HP:0100787)1.93309648
112Chest pain (HP:0100749)1.93212103
113Meckel diverticulum (HP:0002245)1.91331094
114Spontaneous hematomas (HP:0007420)1.89972086
115Impulsivity (HP:0100710)1.88601950
116Recurrent lower respiratory tract infections (HP:0002783)1.88259288
117Abnormality of cells of the erythroid lineage (HP:0012130)1.87799880
118Poikiloderma (HP:0001029)1.87769258
119Acute lymphatic leukemia (HP:0006721)1.86947002
120Pulmonary embolism (HP:0002204)1.85769751
121Aplasia/Hypoplasia of the uvula (HP:0010293)1.85184594
122Fatigue (HP:0012378)1.84865707
123Abnormal number of erythroid precursors (HP:0012131)1.84592476
124Abnormal platelet volume (HP:0011876)1.83887428
125Verrucae (HP:0200043)1.82916703
126Disinhibition (HP:0000734)1.81303958
127Neoplasm of the tracheobronchial system (HP:0100552)1.80392889
128Abnormal foot bone ossification (HP:0010675)1.76263072
129Abnormality of the vasculature of the conjunctiva (HP:0008054)1.74486143
130Keratitis (HP:0000491)1.74400372

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.67038681
2CDC72.79126004
3NEK22.45062407
4TXK2.44758119
5CDK122.35472695
6STK102.24422074
7IRAK42.12961933
8WEE12.09622275
9MAP3K142.06627591
10JAK31.93043012
11EIF2AK11.80779464
12TAOK31.77274596
13BLK1.75442921
14RPS6KA41.71694354
15EEF2K1.69974340
16MAP3K131.66983355
17TYK21.65321860
18PLK41.63701985
19IRAK31.61674171
20PIM11.56129164
21SRPK11.55391096
22FGR1.52548134
23IRAK11.51727461
24TEC1.47443079
25BMPR21.46812058
26PRPF4B1.46577573
27BUB11.43801153
28ZAP701.42721121
29BTK1.41510996
30MATK1.41041431
31BRSK21.41007030
32STK31.40904850
33CDK41.38081921
34IRAK21.37376821
35STK41.36180248
36IKBKB1.36160628
37TBK11.33016982
38MAP3K101.30454894
39YES11.27746614
40ATR1.26699608
41CDK61.26209631
42NUAK11.25095392
43AURKB1.19740523
44PIM21.17724910
45NME21.13630156
46CAMK1G1.13496973
47EIF2AK31.12377070
48ITK1.12090205
49IKBKE1.08546699
50CLK11.08522484
51MAP3K81.08029869
52SYK1.07704116
53TTK1.05883296
54JAK11.05492743
55CHUK1.05402137
56KSR11.05016605
57LRRK21.04356931
58CSF1R1.03814071
59NEK91.02978647
60CSK1.02871438
61MKNK21.02839557
62GRK61.01532371
63MST41.00846203
64TAOK11.00494084
65KIT1.00299727
66MARK30.98398248
67HCK0.95806473
68CDK70.95197519
69PLK10.93673331
70NEK60.89625758
71MKNK10.88995020
72RIPK40.88904752
73MAP3K30.88198052
74* CHEK10.87878961
75LCK0.87560658
76TSSK60.87363701
77ACVR1B0.86447678
78MAP3K20.86366096
79TESK20.86226990
80DYRK30.85753295
81CHEK20.85660766
82FGFR30.85376310
83MAP3K10.85182571
84ALK0.85073521
85GRK70.84504394
86RPS6KB20.83775387
87SIK30.82372227
88RAF10.80221366
89WNK10.79734576
90LYN0.76378456
91EIF2AK20.75361465
92TLK10.73768481
93KSR20.73643427
94NLK0.72201674
95ATM0.71946540
96MAP2K30.71872962
97ZAK0.69741213
98SMG10.67531917
99PLK30.64939610
100TTN0.63952358
101TRPM70.63406941
102MOS0.62297980
103BRD40.62032713
104STK240.61544945
105CDK90.61249065
106FGFR40.55870501
107PDK10.55139398
108CDK20.54534251
109PIK3CG0.54117155
110JAK20.53865757
111TRIB30.53768983
112PASK0.52789116
113VRK10.52198102
114DMPK0.51703712
115PKN20.51030695
116TGFBR20.50982596
117EPHB10.50657855
118MELK0.50171927
119FES0.49430223
120ERN10.48113563
121BRSK10.46066285
122TNK20.45631773
123MAPKAPK20.45191453
124PNCK0.44151772
125ABL10.43539287
126SCYL20.43486035
127CAMK1D0.43338828
128MAP3K50.43117834
129TAOK20.42107952

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030302.86844189
2Primary immunodeficiency_Homo sapiens_hsa053402.29734162
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.20327420
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.09565096
5Leishmaniasis_Homo sapiens_hsa051402.04750629
6Intestinal immune network for IgA production_Homo sapiens_hsa046721.98557816
7Mismatch repair_Homo sapiens_hsa034301.98004250
8Cell cycle_Homo sapiens_hsa041101.97635508
9Homologous recombination_Homo sapiens_hsa034401.97020228
10Base excision repair_Homo sapiens_hsa034101.92101979
11Antigen processing and presentation_Homo sapiens_hsa046121.90475464
12RNA transport_Homo sapiens_hsa030131.87172190
13Measles_Homo sapiens_hsa051621.81559989
14Spliceosome_Homo sapiens_hsa030401.79133221
15Non-homologous end-joining_Homo sapiens_hsa034501.77461917
16Allograft rejection_Homo sapiens_hsa053301.77417195
17B cell receptor signaling pathway_Homo sapiens_hsa046621.76565592
18Herpes simplex infection_Homo sapiens_hsa051681.74177865
19Fanconi anemia pathway_Homo sapiens_hsa034601.72360881
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.64165563
21Hematopoietic cell lineage_Homo sapiens_hsa046401.63171429
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.60088177
23NOD-like receptor signaling pathway_Homo sapiens_hsa046211.56114814
24Osteoclast differentiation_Homo sapiens_hsa043801.54900933
25p53 signaling pathway_Homo sapiens_hsa041151.53802068
26Graft-versus-host disease_Homo sapiens_hsa053321.53329110
27Asthma_Homo sapiens_hsa053101.44151544
28Legionellosis_Homo sapiens_hsa051341.38291244
29Epstein-Barr virus infection_Homo sapiens_hsa051691.37879774
30Ribosome_Homo sapiens_hsa030101.37462978
31Nucleotide excision repair_Homo sapiens_hsa034201.35719485
32One carbon pool by folate_Homo sapiens_hsa006701.35308920
33T cell receptor signaling pathway_Homo sapiens_hsa046601.32360713
34RNA polymerase_Homo sapiens_hsa030201.32024287
35Apoptosis_Homo sapiens_hsa042101.28121626
36RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.28036039
37Toll-like receptor signaling pathway_Homo sapiens_hsa046201.27799892
38Viral carcinogenesis_Homo sapiens_hsa052031.25338628
39Jak-STAT signaling pathway_Homo sapiens_hsa046301.24014010
40Influenza A_Homo sapiens_hsa051641.22816380
41Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.22705237
42Toxoplasmosis_Homo sapiens_hsa051451.20141741
43Hepatitis B_Homo sapiens_hsa051611.16351067
44Small cell lung cancer_Homo sapiens_hsa052221.15545897
45Basal transcription factors_Homo sapiens_hsa030221.14381933
46mRNA surveillance pathway_Homo sapiens_hsa030151.12264364
47TNF signaling pathway_Homo sapiens_hsa046681.11943159
48Chronic myeloid leukemia_Homo sapiens_hsa052201.10899311
49RNA degradation_Homo sapiens_hsa030181.10583168
50Systemic lupus erythematosus_Homo sapiens_hsa053221.09447344
51Viral myocarditis_Homo sapiens_hsa054161.08509863
52Transcriptional misregulation in cancer_Homo sapiens_hsa052021.06913035
53Malaria_Homo sapiens_hsa051441.06572977
54Pyrimidine metabolism_Homo sapiens_hsa002401.06118459
55Tuberculosis_Homo sapiens_hsa051521.05533548
56Autoimmune thyroid disease_Homo sapiens_hsa053201.05454340
57HTLV-I infection_Homo sapiens_hsa051661.02602057
58Shigellosis_Homo sapiens_hsa051311.02532703
59Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.01428214
60Acute myeloid leukemia_Homo sapiens_hsa052210.99317632
61Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.99124485
62Leukocyte transendothelial migration_Homo sapiens_hsa046700.97905794
63Renal cell carcinoma_Homo sapiens_hsa052110.96106462
64MicroRNAs in cancer_Homo sapiens_hsa052060.94550129
65Dorso-ventral axis formation_Homo sapiens_hsa043200.90238316
66Pertussis_Homo sapiens_hsa051330.89371455
67Rheumatoid arthritis_Homo sapiens_hsa053230.86993926
68VEGF signaling pathway_Homo sapiens_hsa043700.84788063
69Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.84785455
70Bladder cancer_Homo sapiens_hsa052190.82060025
71Pancreatic cancer_Homo sapiens_hsa052120.81576381
72Proteasome_Homo sapiens_hsa030500.81338826
73Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.80584693
74Pentose phosphate pathway_Homo sapiens_hsa000300.79548986
75Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.78457941
76Chemokine signaling pathway_Homo sapiens_hsa040620.77965807
77Staphylococcus aureus infection_Homo sapiens_hsa051500.77157660
78AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.69504290
79Salmonella infection_Homo sapiens_hsa051320.69010814
80Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.68030662
81Endometrial cancer_Homo sapiens_hsa052130.67727392
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.66206350
83Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.65814056
84Hepatitis C_Homo sapiens_hsa051600.65713770
85Phagosome_Homo sapiens_hsa041450.65374125
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.60962990
87Platelet activation_Homo sapiens_hsa046110.59871907
88Amoebiasis_Homo sapiens_hsa051460.58815795
89Adipocytokine signaling pathway_Homo sapiens_hsa049200.58152002
90Vitamin B6 metabolism_Homo sapiens_hsa007500.56947023
91Prostate cancer_Homo sapiens_hsa052150.54661680
92Type I diabetes mellitus_Homo sapiens_hsa049400.54427762
93ErbB signaling pathway_Homo sapiens_hsa040120.53860169
94Non-small cell lung cancer_Homo sapiens_hsa052230.53816629
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53687171
96FoxO signaling pathway_Homo sapiens_hsa040680.52233073
97Inositol phosphate metabolism_Homo sapiens_hsa005620.51180975
98HIF-1 signaling pathway_Homo sapiens_hsa040660.48968881
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.48582294
100Glioma_Homo sapiens_hsa052140.48546348
101Phosphatidylinositol signaling system_Homo sapiens_hsa040700.48508321
102Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.48247775
103Fatty acid biosynthesis_Homo sapiens_hsa000610.48207167
104Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46219170
105Notch signaling pathway_Homo sapiens_hsa043300.42197619
106African trypanosomiasis_Homo sapiens_hsa051430.42170204
107Renin-angiotensin system_Homo sapiens_hsa046140.40780535
108Thyroid cancer_Homo sapiens_hsa052160.40669803
109Neurotrophin signaling pathway_Homo sapiens_hsa047220.40049661
110Adherens junction_Homo sapiens_hsa045200.39361765
111Colorectal cancer_Homo sapiens_hsa052100.39102395
112Prolactin signaling pathway_Homo sapiens_hsa049170.38883085
113Purine metabolism_Homo sapiens_hsa002300.37994917
114Other glycan degradation_Homo sapiens_hsa005110.37363547
115Proteoglycans in cancer_Homo sapiens_hsa052050.36185588
116mTOR signaling pathway_Homo sapiens_hsa041500.35006552

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