BAX

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1formation of translation preinitiation complex (GO:0001731)4.54487647
2DNA deamination (GO:0045006)4.41771714
3viral transcription (GO:0019083)4.22324168
4ribosomal small subunit assembly (GO:0000028)4.22274825
5folic acid-containing compound biosynthetic process (GO:0009396)4.14569268
6translational termination (GO:0006415)4.08352398
7maturation of SSU-rRNA (GO:0030490)4.07173034
8regulation of posttranscriptional gene silencing (GO:0060147)3.99958242
9regulation of gene silencing by miRNA (GO:0060964)3.99958242
10regulation of gene silencing by RNA (GO:0060966)3.99958242
11protein localization to endosome (GO:0036010)3.99011008
12ribosomal small subunit biogenesis (GO:0042274)3.98302402
13pinocytosis (GO:0006907)3.92367581
14NIK/NF-kappaB signaling (GO:0038061)3.91036279
15DNA strand elongation involved in DNA replication (GO:0006271)3.86678920
16translational elongation (GO:0006414)3.79556958
17translational initiation (GO:0006413)3.77049491
18mannose metabolic process (GO:0006013)3.71640883
19telomere maintenance via semi-conservative replication (GO:0032201)3.68732456
20DNA strand elongation (GO:0022616)3.66374215
21DNA unwinding involved in DNA replication (GO:0006268)3.64848146
22ribosome biogenesis (GO:0042254)3.61893824
23ribonucleoprotein complex biogenesis (GO:0022613)3.60883855
24ribosome assembly (GO:0042255)3.57959228
25DNA replication initiation (GO:0006270)3.56127289
26protein localization to kinetochore (GO:0034501)3.54644866
27mitotic nuclear envelope disassembly (GO:0007077)3.51700914
28nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.50820995
29Golgi transport vesicle coating (GO:0048200)3.49781509
30COPI coating of Golgi vesicle (GO:0048205)3.49781509
31DNA replication-dependent nucleosome assembly (GO:0006335)3.49582767
32DNA replication-dependent nucleosome organization (GO:0034723)3.49582767
33ribosomal large subunit biogenesis (GO:0042273)3.48465405
34IMP biosynthetic process (GO:0006188)3.47441516
35SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.45510661
36nucleobase biosynthetic process (GO:0046112)3.43818633
37barbed-end actin filament capping (GO:0051016)3.42417848
38modulation by symbiont of host cellular process (GO:0044068)3.39055293
39negative regulation of erythrocyte differentiation (GO:0045647)3.36352289
40protein targeting to ER (GO:0045047)3.35402044
41regulation of translational fidelity (GO:0006450)3.35278353
42pentose-phosphate shunt (GO:0006098)3.33620452
43cotranslational protein targeting to membrane (GO:0006613)3.32969758
44viral life cycle (GO:0019058)3.32944676
45regulation of early endosome to late endosome transport (GO:2000641)3.32322726
46modulation by symbiont of host defense response (GO:0052031)3.30769150
47modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.30769150
48modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.30769150
49positive regulation by organism of defense response of other organism involved in symbiotic interact3.30769150
50modulation by symbiont of host immune response (GO:0052553)3.30769150
51positive regulation by symbiont of host defense response (GO:0052509)3.30769150
52response to peptidoglycan (GO:0032494)3.29863439
53cellular protein complex disassembly (GO:0043624)3.24904793
54nuclear envelope disassembly (GO:0051081)3.23932233
55membrane disassembly (GO:0030397)3.23932233
56spliceosomal snRNP assembly (GO:0000387)3.21558516
57heterochromatin organization (GO:0070828)3.18539235
58telomere maintenance via recombination (GO:0000722)3.16149853
59establishment of protein localization to endoplasmic reticulum (GO:0072599)3.15552790
60rRNA processing (GO:0006364)3.14890830
61positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.14188559
62mitotic metaphase plate congression (GO:0007080)3.10293954
63protein localization to endoplasmic reticulum (GO:0070972)3.09788868
64negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.06955217
65modulation by virus of host process (GO:0019054)3.06867597
66stress fiber assembly (GO:0043149)3.04334264
67rRNA metabolic process (GO:0016072)3.01341541
68protein complex disassembly (GO:0043241)2.98516946
69regulation of extracellular matrix disassembly (GO:0010715)2.98307219
70peptidyl-arginine omega-N-methylation (GO:0035247)2.96617678
71histone arginine methylation (GO:0034969)2.96454635
72purine nucleobase biosynthetic process (GO:0009113)2.95557952
73telomere maintenance via telomere lengthening (GO:0010833)2.95514428
74regulation of type I interferon-mediated signaling pathway (GO:0060338)2.94731996
75DNA replication checkpoint (GO:0000076)2.94067457
76protein localization to chromosome, centromeric region (GO:0071459)2.93713794
77myeloid dendritic cell differentiation (GO:0043011)2.92418497
78mitotic recombination (GO:0006312)2.92403573
79mitotic sister chromatid segregation (GO:0000070)2.91771816
80positive regulation of Cdc42 GTPase activity (GO:0043089)2.90318343
81hyaluronan catabolic process (GO:0030214)2.90105585
82* negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.89118928
83IMP metabolic process (GO:0046040)2.88021714
843-UTR-mediated mRNA stabilization (GO:0070935)2.87001298
85translation (GO:0006412)2.86958005
86pseudouridine synthesis (GO:0001522)2.86753920
87proline biosynthetic process (GO:0006561)2.86632197
88NADPH regeneration (GO:0006740)2.85562565
89antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.84327727
90negative regulation of RNA splicing (GO:0033119)2.83420389
91antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.83353843
92basement membrane organization (GO:0071711)2.83087960
93activation of MAPKKK activity (GO:0000185)2.82076671
94regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.80725398
95macromolecular complex disassembly (GO:0032984)2.80503517
96establishment of integrated proviral latency (GO:0075713)2.80026887
97nucleotide-excision repair, DNA gap filling (GO:0006297)2.80004974
98negative regulation of interleukin-12 production (GO:0032695)2.77915433
99negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.77600150
100nuclear pore organization (GO:0006999)2.77370698
101proteasome assembly (GO:0043248)2.76669546
102protein retention in ER lumen (GO:0006621)2.75916694
103nuclear-transcribed mRNA catabolic process (GO:0000956)2.75595059
104somatic hypermutation of immunoglobulin genes (GO:0016446)2.75142143
105somatic diversification of immune receptors via somatic mutation (GO:0002566)2.75142143
106mitotic G1 DNA damage checkpoint (GO:0031571)2.74924686
107amino sugar catabolic process (GO:0046348)2.74801907
108protein maturation by protein folding (GO:0022417)2.71413051
109lipopolysaccharide-mediated signaling pathway (GO:0031663)2.71337656
110maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.71243545
111DNA duplex unwinding (GO:0032508)2.71207283
112anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.70613972
113DNA geometric change (GO:0032392)2.70259115
114positive regulation of SMAD protein import into nucleus (GO:0060391)2.69110218
115glucose catabolic process (GO:0006007)2.68442398
116regulation of translational termination (GO:0006449)2.67191647
117antigen processing and presentation of endogenous antigen (GO:0019883)2.67118637
118termination of RNA polymerase II transcription (GO:0006369)2.66200761
119pteridine-containing compound biosynthetic process (GO:0042559)2.65511959
120RNA splicing, via transesterification reactions (GO:0000375)2.65221727
121RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.64632689
122mRNA splicing, via spliceosome (GO:0000398)2.64632689
123spliceosomal complex assembly (GO:0000245)2.63621405
124regulation of spindle organization (GO:0090224)2.63371128
125GDP-mannose metabolic process (GO:0019673)2.62587903
126negative regulation of ligase activity (GO:0051352)2.62244327
127negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.62244327
128glycosphingolipid catabolic process (GO:0046479)2.62002436
129mRNA catabolic process (GO:0006402)2.61968760
130regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.61885063
131RNA catabolic process (GO:0006401)2.61496460
132adhesion of symbiont to host (GO:0044406)2.61169346
133regulation of helicase activity (GO:0051095)2.60685112
134positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.60528789
135positive regulation of gamma-delta T cell activation (GO:0046645)2.60454033
136DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.59991869
137immunoglobulin mediated immune response (GO:0016064)2.59916404
138skin morphogenesis (GO:0043589)2.58619844
139transcription-coupled nucleotide-excision repair (GO:0006283)2.58228157
140nucleobase-containing small molecule interconversion (GO:0015949)2.57961955
141signal transduction involved in DNA integrity checkpoint (GO:0072401)2.56630659
142signal transduction involved in DNA damage checkpoint (GO:0072422)2.56630659
143cellular response to virus (GO:0098586)2.56171015
144intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.55858260
145signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.55858260
146negative regulation of mRNA processing (GO:0050686)2.55182775
147signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.54856371
148signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.54856371
149signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.54856371
150virion attachment to host cell (GO:0019062)2.54630389
151adhesion of symbiont to host cell (GO:0044650)2.54630389
152response to muramyl dipeptide (GO:0032495)2.54270014
153positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.53663551
154glucose 6-phosphate metabolic process (GO:0051156)2.52995830
155UV protection (GO:0009650)2.50647394
156negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.49545226
157negative regulation of cell killing (GO:0031342)2.49545226
158response to laminar fluid shear stress (GO:0034616)2.47411150
159negative regulation of viral release from host cell (GO:1902187)2.47160401
160myeloid dendritic cell activation (GO:0001773)2.44131140
161pentose metabolic process (GO:0019321)2.43866800
162regulation of superoxide anion generation (GO:0032928)2.42933146
163activation of Rac GTPase activity (GO:0032863)2.42646882
164amyloid precursor protein catabolic process (GO:0042987)2.42419227
165embryonic process involved in female pregnancy (GO:0060136)2.41170995
166regulation of defense response to virus by virus (GO:0050690)2.41005975
167focal adhesion assembly (GO:0048041)2.40032229
168cell-substrate adherens junction assembly (GO:0007045)2.40032229
169activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.39159953
170adherens junction assembly (GO:0034333)2.38624223
171negative regulation of cell size (GO:0045792)2.38472283
172regulation of interferon-beta biosynthetic process (GO:0045357)2.38016076
173positive regulation of nuclease activity (GO:0032075)2.32284828
174negative regulation of myeloid cell apoptotic process (GO:0033033)2.31002292
175spliceosomal tri-snRNP complex assembly (GO:0000244)2.27807828
176glycolipid catabolic process (GO:0019377)2.26438413
177regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.25705007
178positive regulation of extracellular matrix organization (GO:1903055)2.23160818
179retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.23101653
180cellular response to type I interferon (GO:0071357)2.21592015
181type I interferon signaling pathway (GO:0060337)2.21592015
182macrophage activation involved in immune response (GO:0002281)2.20551252
183positive regulation of blood vessel endothelial cell migration (GO:0043536)2.19477739
184response to type I interferon (GO:0034340)2.18898724
185apoptotic cell clearance (GO:0043277)2.18733504
186endoplasmic reticulum unfolded protein response (GO:0030968)2.18713107
187maternal placenta development (GO:0001893)2.17831422
188mitotic nuclear envelope reassembly (GO:0007084)2.17276623
189nuclear envelope reassembly (GO:0031468)2.17276623
190regulation of leukocyte degranulation (GO:0043300)2.16999565
191modulation by virus of host morphology or physiology (GO:0019048)2.16836129
192regulation of vitamin D biosynthetic process (GO:0060556)2.16493236
193dendritic cell differentiation (GO:0097028)2.16420459
194negative regulation of phagocytosis (GO:0050765)2.15695670
195positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.15585031
196regulation of nuclease activity (GO:0032069)2.15351542
197planar cell polarity pathway involved in neural tube closure (GO:0090179)2.14987526
198positive thymic T cell selection (GO:0045059)2.14618663
199embryo implantation (GO:0007566)2.13794159

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.84452282
2* MYC_18555785_ChIP-Seq_MESCs_Mouse3.97193870
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.80229006
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.15839457
5* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.95624657
6* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.63051811
7* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.60089802
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.52577430
9LXR_22292898_ChIP-Seq_THP-1_Human2.45064074
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.44685715
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.41818098
12* ETS1_20019798_ChIP-Seq_JURKAT_Human2.41329040
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.36511786
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.33123955
15RARG_19884340_ChIP-ChIP_MEFs_Mouse2.29906484
16XRN2_22483619_ChIP-Seq_HELA_Human2.26444555
17NELFA_20434984_ChIP-Seq_ESCs_Mouse2.18334683
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.16008726
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.14390822
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.11039757
21EGR1_19374776_ChIP-ChIP_THP-1_Human2.08090490
22KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.00321991
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.99619150
24NANOG_18555785_ChIP-Seq_MESCs_Mouse1.99310324
25POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.99261283
26MYC_22102868_ChIP-Seq_BL_Human1.98405688
27KDM2B_26808549_Chip-Seq_SUP-B15_Human1.97762325
28THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.95734638
29* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.94689681
30* TP63_17297297_ChIP-ChIP_HaCaT_Human1.91455708
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.86563171
32* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.82915252
33RACK7_27058665_Chip-Seq_MCF-7_Human1.82895350
34VDR_24763502_ChIP-Seq_THP-1_Human1.82268643
35VDR_23849224_ChIP-Seq_CD4+_Human1.78481766
36TCF7_22412390_ChIP-Seq_EML_Mouse1.74830693
37DCP1A_22483619_ChIP-Seq_HELA_Human1.73838473
38MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.73400593
39KDM2B_26808549_Chip-Seq_DND41_Human1.71925349
40MAF_26560356_Chip-Seq_TH1_Human1.71723131
41ELF1_17652178_ChIP-ChIP_JURKAT_Human1.70764491
42STAT3_1855785_ChIP-Seq_MESCs_Mouse1.70432908
43POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.69073514
44KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.67449709
45KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.67449709
46KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.67449709
47GABP_19822575_ChIP-Seq_HepG2_Human1.65632087
48SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.63370206
49TTF2_22483619_ChIP-Seq_HELA_Human1.63276468
50* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.62840851
51MYCN_18555785_ChIP-Seq_MESCs_Mouse1.61856380
52THAP11_20581084_ChIP-Seq_MESCs_Mouse1.59016039
53PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.58915162
54MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.58604568
55FOXP3_21729870_ChIP-Seq_TREG_Human1.54956089
56KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.52727720
57NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.52635514
58MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.51544871
59TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.51275628
60CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.51260324
61BRD4_27068464_Chip-Seq_AML-cells_Mouse1.50670831
62CIITA_25753668_ChIP-Seq_RAJI_Human1.49129835
63UTX_26944678_Chip-Seq_JUKART_Human1.48736999
64NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.45880272
65VDR_21846776_ChIP-Seq_THP-1_Human1.45623669
66IRF8_22096565_ChIP-ChIP_GC-B_Human1.45608912
67TCF3_18692474_ChIP-Seq_MEFs_Mouse1.45548228
68STAT6_21828071_ChIP-Seq_BEAS2B_Human1.45398110
69YY1_21170310_ChIP-Seq_MESCs_Mouse1.44666592
70* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.44473334
71* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.44356656
72* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.44296326
73* TFEB_21752829_ChIP-Seq_HELA_Human1.43760396
74TET1_21451524_ChIP-Seq_MESCs_Mouse1.43168767
75RUNX1_22412390_ChIP-Seq_EML_Mouse1.43124181
76MAF_26560356_Chip-Seq_TH2_Human1.42181457
77RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.41229655
78E2F1_21310950_ChIP-Seq_MCF-7_Human1.40707719
79TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.39286721
80ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.38765046
81E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.38374789
82POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.37836287
83STAT4_19710469_ChIP-ChIP_TH1__Mouse1.37133369
84KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.37009718
85ZNF263_19887448_ChIP-Seq_K562_Human1.36402462
86TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35121258
87* TP53_22127205_ChIP-Seq_IMR90_Human1.34719722
88KLF4_18555785_ChIP-Seq_MESCs_Mouse1.33986741
89SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.32350475
90CTCF_27219007_Chip-Seq_ERYTHROID_Human1.31676201
91* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.29968239
92* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.29735223
93HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.29175792
94UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.29158372
95GATA1_22383799_ChIP-Seq_G1ME_Mouse1.27598038
96P68_20966046_ChIP-Seq_HELA_Human1.27345361
97SA1_27219007_Chip-Seq_ERYTHROID_Human1.27289948
98SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.27066042
99ELK1_19687146_ChIP-ChIP_HELA_Human1.26675500
100KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.26277513
101NCOR1_26117541_ChIP-Seq_K562_Human1.25589779
102ELF1_20517297_ChIP-Seq_JURKAT_Human1.25575086
103KDM5A_27292631_Chip-Seq_BREAST_Human1.25516893
104* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.25261388
105ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.25101954
106SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.23680127
107ATF3_27146783_Chip-Seq_COLON_Human1.23284586
108PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22123411
109KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.21949915
110PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20771897
111AR_21909140_ChIP-Seq_LNCAP_Human1.20179233
112IRF8_21731497_ChIP-ChIP_J774_Mouse1.19240231
113KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.18697803
114ZFP281_18757296_ChIP-ChIP_E14_Mouse1.18638062
115OCT4_18692474_ChIP-Seq_MEFs_Mouse1.18398477
116P300_27058665_Chip-Seq_ZR-75-30cells_Human1.17970964
117MYB_21317192_ChIP-Seq_ERMYB_Mouse1.17219204
118* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.16261740
119SOX2_18555785_ChIP-Seq_MESCs_Mouse1.16203486
120KDM2B_26808549_Chip-Seq_K562_Human1.16128382
121NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.15933302
122TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.15698074
123CLOCK_20551151_ChIP-Seq_293T_Human1.15343297
124CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13736105
125SOX2_18692474_ChIP-Seq_MEFs_Mouse1.13295628
126TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.12014198
127YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11672838
128SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.10980712
129ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.10462678
130* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.08990644
131KDM2B_26808549_Chip-Seq_JURKAT_Human1.08241045
132NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.07699055
133HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.06972897
134SRF_21415370_ChIP-Seq_HL-1_Mouse1.06827141
135BCOR_27268052_Chip-Seq_Bcells_Human1.06426518
136HOXB4_20404135_ChIP-ChIP_EML_Mouse1.06417585
137ELK3_25401928_ChIP-Seq_HUVEC_Human1.05509699
138FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.05246408
139PU.1_20513432_ChIP-Seq_Bcells_Mouse1.05075962
140KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.04651439
141SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04143014
142ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.03959862
143CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.03498638
144SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.01961959
145SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.01820364
146SPI1_23547873_ChIP-Seq_NB4_Human1.01747009
147ERG_20887958_ChIP-Seq_HPC-7_Mouse1.01745620
148* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.01042979
149BCL6_27268052_Chip-Seq_Bcells_Human0.99799824
150CTCF_26484167_Chip-Seq_Bcells_Mouse0.98950923
151SRY_22984422_ChIP-ChIP_TESTIS_Rat0.97701945
152ELK1_22589737_ChIP-Seq_MCF10A_Human0.97608236
153CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.96936863
154TCF3_18692474_ChIP-Seq_MESCs_Mouse0.95616663
155NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.94717906
156CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.94298538
157BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.94094460
158NOTCH1_21737748_ChIP-Seq_TLL_Human0.93695558
159CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.92371034
160NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.91305626
161E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.91228840

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.11522784
2MP0004957_abnormal_blastocyst_morpholog3.67426706
3MP0003111_abnormal_nucleus_morphology3.54879731
4MP0003077_abnormal_cell_cycle3.14876612
5MP0010352_gastrointestinal_tract_polyps3.10353716
6MP0010094_abnormal_chromosome_stability2.89359772
7MP0009840_abnormal_foam_cell2.70400647
8MP0008057_abnormal_DNA_replication2.51921519
9MP0005451_abnormal_body_composition2.51295749
10MP0008007_abnormal_cellular_replicative2.42808664
11MP0002254_reproductive_system_inflammat2.41135585
12MP0003300_gastrointestinal_ulcer2.39904827
13MP0008932_abnormal_embryonic_tissue2.26827047
14MP0010307_abnormal_tumor_latency2.22191888
15MP0008058_abnormal_DNA_repair2.08939988
16MP0000350_abnormal_cell_proliferation2.07912071
17MP0001730_embryonic_growth_arrest2.06181712
18MP0010030_abnormal_orbit_morphology1.97115924
19MP0008260_abnormal_autophagy1.93206798
20MP0000490_abnormal_crypts_of1.86348559
21MP0004133_heterotaxia1.79729592
22MP0003941_abnormal_skin_development1.79634318
23MP0000858_altered_metastatic_potential1.77749801
24MP0003806_abnormal_nucleotide_metabolis1.75288517
25MP0009333_abnormal_splenocyte_physiolog1.73370629
26MP0002419_abnormal_innate_immunity1.72222408
27MP0003705_abnormal_hypodermis_morpholog1.71632624
28MP0005387_immune_system_phenotype1.69700531
29MP0001790_abnormal_immune_system1.69700531
30MP0003191_abnormal_cellular_cholesterol1.68955660
31MP0005076_abnormal_cell_differentiation1.68706795
32MP0005464_abnormal_platelet_physiology1.65902230
33MP0002653_abnormal_ependyma_morphology1.65374950
34MP0003566_abnormal_cell_adhesion1.61033607
35MP0003786_premature_aging1.59180407
36MP0001697_abnormal_embryo_size1.57955104
37MP0001672_abnormal_embryogenesis/_devel1.55129496
38MP0005380_embryogenesis_phenotype1.55129496
39MP0002148_abnormal_hypersensitivity_rea1.53548510
40MP0009278_abnormal_bone_marrow1.50922275
41MP0002085_abnormal_embryonic_tissue1.49727072
42* MP0002080_prenatal_lethality1.49036819
43MP0005023_abnormal_wound_healing1.47815527
44MP0004858_abnormal_nervous_system1.47178637
45MP0001533_abnormal_skeleton_physiology1.46235629
46* MP0000313_abnormal_cell_death1.43644231
47MP0002019_abnormal_tumor_incidence1.41114844
48MP0004510_myositis1.40513150
49MP0002084_abnormal_developmental_patter1.40134604
50MP0005671_abnormal_response_to1.40129275
51MP0004272_abnormal_basement_membrane1.39106198
52MP0003436_decreased_susceptibility_to1.39100254
53MP0002086_abnormal_extraembryonic_tissu1.38929644
54MP0003984_embryonic_growth_retardation1.38093993
55MP0004197_abnormal_fetal_growth/weight/1.37249847
56MP0005397_hematopoietic_system_phenotyp1.35566040
57MP0001545_abnormal_hematopoietic_system1.35566040
58MP0002088_abnormal_embryonic_growth/wei1.34818158
59MP0002998_abnormal_bone_remodeling1.34388598
60MP0002396_abnormal_hematopoietic_system1.33976586
61MP0000685_abnormal_immune_system1.27154532
62MP0010155_abnormal_intestine_physiology1.26954977
63MP0003123_paternal_imprinting1.24567688
64MP0008438_abnormal_cutaneous_collagen1.24221305
65MP0000604_amyloidosis1.22194114
66MP0004808_abnormal_hematopoietic_stem1.21116638
67MP0001293_anophthalmia1.19789734
68MP0003448_altered_tumor_morphology1.16257049
69* MP0002722_abnormal_immune_system1.14785707
70MP0003890_abnormal_embryonic-extraembry1.14125383
71* MP0002398_abnormal_bone_marrow1.12894653
72MP0001845_abnormal_inflammatory_respons1.11681553
73MP0005623_abnormal_meninges_morphology1.11605654
74MP0003119_abnormal_digestive_system1.11155146
75MP0002405_respiratory_system_inflammati1.10890544
76MP0000767_abnormal_smooth_muscle1.09874060
77MP0001542_abnormal_bone_strength1.09251201
78MP0001348_abnormal_lacrimal_gland1.09188865
79MP0000343_altered_response_to1.08953249
80* MP0000689_abnormal_spleen_morphology1.08444990
81MP0001915_intracranial_hemorrhage1.08172178
82MP0001849_ear_inflammation1.06702925
83MP0002877_abnormal_melanocyte_morpholog1.06534948
84MP0002139_abnormal_hepatobiliary_system1.05063291
85MP0005257_abnormal_intraocular_pressure1.04271584
86MP0004185_abnormal_adipocyte_glucose1.04252230
87* MP0000703_abnormal_thymus_morphology1.02682980
88MP0003718_maternal_effect1.02380283
89MP0008469_abnormal_protein_level1.02126200
90MP0003075_altered_response_to1.01485584
91MP0001958_emphysema1.00562580
92MP0003186_abnormal_redox_activity1.00039735
93MP0005390_skeleton_phenotype0.99788190
94* MP0000358_abnormal_cell_content/0.98685656
95MP0005621_abnormal_cell_physiology0.97469435
96MP0003763_abnormal_thymus_physiology0.97045321
97MP0002111_abnormal_tail_morphology0.96132530
98MP0003172_abnormal_lysosome_physiology0.95854204
99* MP0002429_abnormal_blood_cell0.94179427
100MP0001835_abnormal_antigen_presentation0.94063355
101MP0003329_amyloid_beta_deposits0.94019849
102MP0002452_abnormal_antigen_presenting0.90393849
103MP0005310_abnormal_salivary_gland0.90356420
104MP0006054_spinal_hemorrhage0.89181831
105* MP0005384_cellular_phenotype0.89036339
106MP0000733_abnormal_muscle_development0.88837043
107MP0005000_abnormal_immune_tolerance0.88547314
108MP0001873_stomach_inflammation0.88344745
109MP0003283_abnormal_digestive_organ0.87859102
110MP0003453_abnormal_keratinocyte_physiol0.87129838
111MP0001853_heart_inflammation0.86419670
112MP0005058_abnormal_lysosome_morphology0.86098840
113MP0006082_CNS_inflammation0.85645294
114* MP0000716_abnormal_immune_system0.84644679
115MP0001800_abnormal_humoral_immune0.84413920
116MP0003567_abnormal_fetal_cardiomyocyte0.84052899
117MP0000003_abnormal_adipose_tissue0.82950443
118MP0004233_abnormal_muscle_weight0.82892877
119MP0002933_joint_inflammation0.82005308
120MP0001819_abnormal_immune_cell0.81940941
121MP0000477_abnormal_intestine_morphology0.81639081
122MP0002420_abnormal_adaptive_immunity0.81277572
123MP0000428_abnormal_craniofacial_morphol0.80652454
124MP0009785_altered_susceptibility_to0.80140949
125MP0000371_diluted_coat_color0.77954939
126MP0003795_abnormal_bone_structure0.77905501
127MP0002723_abnormal_immune_serum0.77413560
128MP0002060_abnormal_skin_morphology0.76867840
129MP0004947_skin_inflammation0.76643854
130MP0003091_abnormal_cell_migration0.73963077
131MP0009384_cardiac_valve_regurgitation0.72888622
132MP0005025_abnormal_response_to0.72559555
133MP0005501_abnormal_skin_physiology0.71523093
134MP0003183_abnormal_peptide_metabolism0.71521719
135MP0009053_abnormal_anal_canal0.71289747
136MP0001243_abnormal_dermal_layer0.70672351
137MP0003279_aneurysm0.70290768
138MP0002092_abnormal_eye_morphology0.69260098
139MP0003303_peritoneal_inflammation0.69201580
140MP0000678_abnormal_parathyroid_gland0.67894221
141MP0002697_abnormal_eye_size0.66414788
142MP0002132_abnormal_respiratory_system0.65139966

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.12645027
2Selective tooth agenesis (HP:0001592)3.70232974
3Abnormality of glycolipid metabolism (HP:0010969)3.65320152
4Abnormality of liposaccharide metabolism (HP:0010968)3.65320152
5Abnormality of glycosphingolipid metabolism (HP:0004343)3.65320152
6Trismus (HP:0000211)3.46441748
7Ependymoma (HP:0002888)3.32715317
8Abnormality of cells of the erythroid lineage (HP:0012130)3.31442707
9Increased cerebral lipofuscin (HP:0011813)3.03227902
10Abnormal number of erythroid precursors (HP:0012131)3.02935998
11Agnosia (HP:0010524)3.01744544
12Dysostosis multiplex (HP:0000943)3.01425177
13Abnormality of the anterior horn cell (HP:0006802)3.01224654
14Degeneration of anterior horn cells (HP:0002398)3.01224654
15Rough bone trabeculation (HP:0100670)2.93515418
16Protrusio acetabuli (HP:0003179)2.89904977
17Multiple enchondromatosis (HP:0005701)2.88881400
18Achilles tendon contracture (HP:0001771)2.83377672
19Breast hypoplasia (HP:0003187)2.81203798
20Abnormality of macrophages (HP:0004311)2.78219615
21Birth length less than 3rd percentile (HP:0003561)2.76401640
22Colon cancer (HP:0003003)2.75452837
23Pallor (HP:0000980)2.72150200
24Absent radius (HP:0003974)2.71590437
25Increased neuronal autofluorescent lipopigment (HP:0002074)2.71550485
26Hyperacusis (HP:0010780)2.69998523
27Aplasia/Hypoplasia of the sacrum (HP:0008517)2.65769192
28Patellar aplasia (HP:0006443)2.61691906
29Missing ribs (HP:0000921)2.60039220
30Eczematoid dermatitis (HP:0000976)2.58928749
31Absent thumb (HP:0009777)2.57206522
32Abnormality of the Achilles tendon (HP:0005109)2.56968793
33Absent forearm bone (HP:0003953)2.56420488
34Aplasia involving forearm bones (HP:0009822)2.56420488
35Oral leukoplakia (HP:0002745)2.50771265
36Gastrointestinal stroma tumor (HP:0100723)2.47089847
37Carpal bone hypoplasia (HP:0001498)2.44788174
38Cellulitis (HP:0100658)2.42908972
39Aplasia/hypoplasia of the humerus (HP:0006507)2.42467650
40Aplasia/Hypoplasia of the patella (HP:0006498)2.41248043
41Premature graying of hair (HP:0002216)2.40800673
42Neoplasm of the pancreas (HP:0002894)2.40276829
43Abdominal situs inversus (HP:0003363)2.39823014
44Abnormality of abdominal situs (HP:0011620)2.39823014
45Vacuolated lymphocytes (HP:0001922)2.39063103
46Astrocytoma (HP:0009592)2.38169519
47Abnormality of the astrocytes (HP:0100707)2.38169519
48Emphysema (HP:0002097)2.37508610
49Abnormality of mucopolysaccharide metabolism (HP:0011020)2.36081166
50Abnormality of polysaccharide metabolism (HP:0011012)2.36081166
51Abnormality of glycosaminoglycan metabolism (HP:0004371)2.36081166
52Vertebral compression fractures (HP:0002953)2.36035719
53Recurrent abscess formation (HP:0002722)2.35936004
54Macrocytic anemia (HP:0001972)2.35513214
55Medulloblastoma (HP:0002885)2.32248010
56Urinary glycosaminoglycan excretion (HP:0003541)2.32074251
57Mucopolysacchariduria (HP:0008155)2.32074251
58Rib fusion (HP:0000902)2.30697952
59Recurrent bacterial skin infections (HP:0005406)2.29955962
60Loss of speech (HP:0002371)2.28933849
61Tracheoesophageal fistula (HP:0002575)2.26503035
62Vertebral hypoplasia (HP:0008417)2.26353208
63Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.26353208
64Basal cell carcinoma (HP:0002671)2.24932879
65Systemic lupus erythematosus (HP:0002725)2.24768175
6611 pairs of ribs (HP:0000878)2.24512794
67Blue sclerae (HP:0000592)2.22107112
68Disproportionate tall stature (HP:0001519)2.21987436
69Chromosomal breakage induced by crosslinking agents (HP:0003221)2.21856181
70Abnormal number of incisors (HP:0011064)2.20822346
71Biconcave vertebral bodies (HP:0004586)2.19043047
72Long palpebral fissure (HP:0000637)2.18849723
73Microretrognathia (HP:0000308)2.18076459
74Cerebral hypomyelination (HP:0006808)2.17643701
75Hypertensive crisis (HP:0100735)2.16808237
76Personality changes (HP:0000751)2.16457516
77Spinal muscular atrophy (HP:0007269)2.15855603
78Ankle contracture (HP:0006466)2.15082672
79Abnormality of the ileum (HP:0001549)2.14116825
80Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.13526459
81Myocardial infarction (HP:0001658)2.12648741
82Abnormal trabecular bone morphology (HP:0100671)2.11976378
83Atrophy/Degeneration involving motor neurons (HP:0007373)2.11915606
84Chromsome breakage (HP:0040012)2.11854214
85Purpura (HP:0000979)2.10735297
86Nuclear cataract (HP:0100018)2.10445807
87Mediastinal lymphadenopathy (HP:0100721)2.09829397
88Nonimmune hydrops fetalis (HP:0001790)2.08761390
89Abnormality of the thoracic spine (HP:0100711)2.07247646
90Chronic obstructive pulmonary disease (HP:0006510)2.05907108
91Obstructive lung disease (HP:0006536)2.05907108
92Glioma (HP:0009733)2.05090485
93Aplastic anemia (HP:0001915)2.04994385
94Thin bony cortex (HP:0002753)2.04922362
95Premature rupture of membranes (HP:0001788)2.04193599
96Meckel diverticulum (HP:0002245)2.03521734
97Upper motor neuron abnormality (HP:0002127)2.01956405
98Premature ovarian failure (HP:0008209)2.01277905
99Short humerus (HP:0005792)1.99910573
100Fused cervical vertebrae (HP:0002949)1.99736207
101Upper limb amyotrophy (HP:0009129)1.98075369
102Thoracic kyphosis (HP:0002942)1.97914145
103Squamous cell carcinoma (HP:0002860)1.97036122
104Aplasia/Hypoplasia of the uvula (HP:0010293)1.94165111
105Hemorrhage of the eye (HP:0011885)1.93996376
106Spondylolisthesis (HP:0003302)1.93756233
107Myelodysplasia (HP:0002863)1.92938755
108Hand muscle atrophy (HP:0009130)1.91750891
109Abnormality of reticulocytes (HP:0004312)1.91321675
110Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.91101799
111Progressive neurologic deterioration (HP:0002344)1.90629991
112J-shaped sella turcica (HP:0002680)1.88257831
113Bone marrow hypocellularity (HP:0005528)1.87685383
114Supernumerary spleens (HP:0009799)1.87262976
115Fragile skin (HP:0001030)1.86160894
116Petechiae (HP:0000967)1.85027001
117Dilatation of the ascending aorta (HP:0005111)1.84783072
118Entropion (HP:0000621)1.84360170
119Recurrent viral infections (HP:0004429)1.84274853
120Slender long bone (HP:0003100)1.83844634
121Elbow flexion contracture (HP:0002987)1.83294329
122Stridor (HP:0010307)1.83182142
123Increased serum ferritin (HP:0003281)1.83013063
124Bladder diverticulum (HP:0000015)1.82192921
125Tongue fasciculations (HP:0001308)1.81857589
126Breech presentation (HP:0001623)1.80762897
127Amaurosis fugax (HP:0100576)1.78951016
128Neoplasm of the oral cavity (HP:0100649)1.78242976
129Rhabdomyosarcoma (HP:0002859)1.78135251
130Abnormality of cells of the lymphoid lineage (HP:0012140)1.77622579
131Cleft eyelid (HP:0000625)1.77536227
132Broad face (HP:0000283)1.76792640
133Abnormality of the peritoneum (HP:0002585)1.76624133
134Vertebral fusion (HP:0002948)1.76337489
135Wormian bones (HP:0002645)1.76157277
136Thrombocytosis (HP:0001894)1.75017251
137Glossoptosis (HP:0000162)1.74919122
138Genu recurvatum (HP:0002816)1.74370780
139Cellular immunodeficiency (HP:0005374)1.74363651
140Peritonitis (HP:0002586)1.73800984
141Joint stiffness (HP:0001387)1.73659541
142Generalized amyotrophy (HP:0003700)1.73630633
143Cerebral aneurysm (HP:0004944)1.73220681
144Prolonged neonatal jaundice (HP:0006579)1.73004103
145Lymphopenia (HP:0001888)1.72924991
146Abnormality of the labia minora (HP:0012880)1.72731789
147Muscle fibrillation (HP:0010546)1.72073380
148Increased density of long bones (HP:0006392)1.72005823
149Deviation of the thumb (HP:0009603)1.71785008
150Pustule (HP:0200039)1.70454001
151Ulnar bowing (HP:0003031)1.70453869
152Increased connective tissue (HP:0009025)1.70265562
153Axonal loss (HP:0003447)1.69723926
154Spinal rigidity (HP:0003306)1.69613043
155Abnormality of the preputium (HP:0100587)1.69569882
156Lymphoma (HP:0002665)1.69530339
157Asplenia (HP:0001746)1.69343555
158Distal lower limb amyotrophy (HP:0008944)1.69187250
159Abnormality of the calcaneus (HP:0008364)1.69016946
160Deep venous thrombosis (HP:0002625)1.68578997
161Flat acetabular roof (HP:0003180)1.68542503
162Insomnia (HP:0100785)1.68365936
163Abnormality of dentin (HP:0010299)1.67040473
164Orthostatic hypotension (HP:0001278)1.65035552
165Poor head control (HP:0002421)1.64769924
166Proximal placement of thumb (HP:0009623)1.64701701
167Bone pain (HP:0002653)1.64348848
168Asymmetry of the thorax (HP:0001555)1.64319922
169Aseptic necrosis (HP:0010885)1.63681504
170Cervical subluxation (HP:0003308)1.63524128
171Mitral regurgitation (HP:0001653)1.63509392
172Myositis (HP:0100614)1.63431079
173Hepatosplenomegaly (HP:0001433)1.63154577
174Freckling (HP:0001480)1.62713106
175Shallow orbits (HP:0000586)1.62626850
176Restrictive lung disease (HP:0002091)1.62056157
177Triphalangeal thumb (HP:0001199)1.61517768
178Poikiloderma (HP:0001029)1.61457335
179Increased IgE level (HP:0003212)1.60863052
180Abnormality of the motor neurons (HP:0002450)1.60581704
181Abnormal neuron morphology (HP:0012757)1.60581704
182Distal upper limb amyotrophy (HP:0007149)1.60081711
183Spontaneous hematomas (HP:0007420)1.60025285
184Pathologic fracture (HP:0002756)1.59846162
185Aneurysm (HP:0002617)1.59501518
186IgA deficiency (HP:0002720)1.59395409
187Meningitis (HP:0001287)1.58797924
188Premature skin wrinkling (HP:0100678)1.58312705
189Recurrent skin infections (HP:0001581)1.57624225

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.32738447
2SMG13.64533743
3TESK23.31443642
4EPHA23.10305262
5PRPF4B2.99432410
6WEE12.69798422
7NME22.54403084
8PIM22.54310944
9SIK12.22334784
10MAP3K102.10309653
11TESK12.07427187
12CDC72.05996677
13EEF2K2.05805230
14EIF2AK12.03770872
15RPS6KB22.01524627
16PAK41.98766459
17NEK21.94742110
18FGFR41.89744180
19CDK121.77388662
20MAP3K111.72366837
21MAPKAPK31.69432560
22TTK1.68389656
23IRAK41.65487535
24CDK71.65071459
25NEK11.61292629
26MAP3K131.56029675
27STK101.55708214
28MAP3K141.54693501
29RPS6KA41.49879150
30PLK11.44745433
31TSSK61.43115616
32MAP3K81.42583818
33ERN11.41406039
34DYRK31.41347992
35PASK1.40899737
36KDR1.39983654
37SCYL21.39767052
38PIM11.36987633
39SRPK11.35316065
40TLK11.33757490
41LRRK21.32232526
42PKN21.30910916
43MAP4K11.29701760
44ARAF1.26028770
45CDC42BPA1.18007514
46LIMK11.17955879
47PRKD21.17174515
48AURKA1.12551012
49AURKB1.11579700
50RIPK41.11411764
51PLK41.10805885
52BLK1.10567340
53TRIB31.10021216
54ATR1.09603193
55RIPK11.08534872
56ACVR1B1.06635129
57TAOK11.06269885
58EIF2AK31.03911483
59DDR21.03536165
60FLT31.01793345
61VRK10.99288866
62CDK40.97916513
63VRK20.96318340
64SIK30.95293334
65PTK60.93360151
66PAK10.93178931
67MAPK110.92225023
68ALK0.88214634
69BMX0.87694440
70MAP3K10.87653005
71CHEK10.87025422
72CHEK20.86346721
73LATS20.84449909
74PRKCI0.83987275
75TAOK20.83553573
76TGFBR20.83371761
77STK40.81279674
78STK160.80384639
79IKBKB0.80014706
80PRKG20.79790794
81CSF1R0.79624098
82RPS6KA20.78665186
83IRAK30.78456356
84TGFBR10.75439471
85PDPK10.74618948
86EPHB10.74241599
87IRAK20.74120293
88ZAP700.72504415
89FGR0.71429315
90CHUK0.70444880
91RPS6KC10.70417426
92RPS6KL10.70417426
93KSR20.70271254
94CDK60.67997740
95MTOR0.67643315
96PDGFRA0.67492518
97DAPK30.67431395
98ICK0.65607732
99DYRK1B0.65465739
100PAK20.64407785
101SIK20.64351566
102BRAF0.64342573
103TYRO30.63869221
104CDK20.61775425
105GRK60.61528985
106HIPK20.60008863
107JAK30.54966861
108ZAK0.54720285
109IKBKE0.54702677
110ILK0.52957833
111TBK10.52931771
112BTK0.52721645
113MATK0.52526510
114BRSK20.51995876
115PLK30.51995233
116TTN0.51464547
117MAP2K30.49961642
118PRKD30.49866116
119ABL20.49378985
120CSK0.49371261
121CSNK2A20.49202376
122NEK90.47542536
123MARK20.46814543
124RPS6KA60.46223893
125PBK0.46170042
126DYRK20.45591461
127TYK20.44870684
128CSNK2A10.44698959
129MKNK10.43370513
130ATM0.43139467
131MAPKAPK20.42526331
132MAP3K30.42041312
133CAMK1D0.42032104
134PTK20.41097052
135EPHB20.40109002
136DAPK10.39815348
137HCK0.39763837
138AKT20.39495665
139BRD40.38692802
140RPS6KA50.38474444
141CDK90.37618722
142LMTK20.37185999
143CLK10.37039089
144MOS0.36902192
145PDK10.36838033
146MAP2K20.36634547

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.04114220
2Ribosome_Homo sapiens_hsa030103.70557008
3Mismatch repair_Homo sapiens_hsa034303.56202535
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.20408671
5Spliceosome_Homo sapiens_hsa030403.13313337
6Proteasome_Homo sapiens_hsa030503.08780788
7RNA transport_Homo sapiens_hsa030132.71082922
8Base excision repair_Homo sapiens_hsa034102.70739720
9RNA polymerase_Homo sapiens_hsa030202.70039924
10One carbon pool by folate_Homo sapiens_hsa006702.60061227
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.43907969
12Nucleotide excision repair_Homo sapiens_hsa034202.34984702
13Homologous recombination_Homo sapiens_hsa034402.16823369
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.16379918
15Pyrimidine metabolism_Homo sapiens_hsa002402.06823577
16Cell cycle_Homo sapiens_hsa041102.03318616
17* p53 signaling pathway_Homo sapiens_hsa041151.96978392
18Osteoclast differentiation_Homo sapiens_hsa043801.84677822
19B cell receptor signaling pathway_Homo sapiens_hsa046621.83153928
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.72623968
21Fanconi anemia pathway_Homo sapiens_hsa034601.60001843
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.42390195
23RNA degradation_Homo sapiens_hsa030181.37455245
24mRNA surveillance pathway_Homo sapiens_hsa030151.36599890
25Epstein-Barr virus infection_Homo sapiens_hsa051691.34563357
26Staphylococcus aureus infection_Homo sapiens_hsa051501.26304563
27Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.24336936
28Non-small cell lung cancer_Homo sapiens_hsa052231.23189025
29Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.22973856
30Legionellosis_Homo sapiens_hsa051341.21997366
31Pancreatic cancer_Homo sapiens_hsa052121.21960074
32Sulfur relay system_Homo sapiens_hsa041221.18589981
33Antigen processing and presentation_Homo sapiens_hsa046121.17604822
34* Tuberculosis_Homo sapiens_hsa051521.16513019
35Bladder cancer_Homo sapiens_hsa052191.16002679
36VEGF signaling pathway_Homo sapiens_hsa043701.15208614
37Shigellosis_Homo sapiens_hsa051311.14767932
38Basal transcription factors_Homo sapiens_hsa030221.14676392
39Autoimmune thyroid disease_Homo sapiens_hsa053201.11017969
40* Viral carcinogenesis_Homo sapiens_hsa052031.10379288
41Hepatitis C_Homo sapiens_hsa051601.07259038
42Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.03336881
43Herpes simplex infection_Homo sapiens_hsa051681.02635177
44* AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.02523591
45Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.99272433
46* Apoptosis_Homo sapiens_hsa042100.98339464
47T cell receptor signaling pathway_Homo sapiens_hsa046600.93603645
48Small cell lung cancer_Homo sapiens_hsa052220.92646558
49* Prion diseases_Homo sapiens_hsa050200.91808779
50Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.91782192
51Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.91430160
52Non-homologous end-joining_Homo sapiens_hsa034500.90963565
53Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.89599416
54MicroRNAs in cancer_Homo sapiens_hsa052060.87826939
55* HTLV-I infection_Homo sapiens_hsa051660.87216255
56Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.86390275
57Rheumatoid arthritis_Homo sapiens_hsa053230.84936256
58NF-kappa B signaling pathway_Homo sapiens_hsa040640.84179404
59Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.83648449
60* Neurotrophin signaling pathway_Homo sapiens_hsa047220.83186950
61Amoebiasis_Homo sapiens_hsa051460.81769886
62Systemic lupus erythematosus_Homo sapiens_hsa053220.81078055
63Leishmaniasis_Homo sapiens_hsa051400.80657814
64Vibrio cholerae infection_Homo sapiens_hsa051100.80615368
65Folate biosynthesis_Homo sapiens_hsa007900.80527964
66Pentose phosphate pathway_Homo sapiens_hsa000300.80454764
67Notch signaling pathway_Homo sapiens_hsa043300.80291391
68Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.80242938
69Biosynthesis of amino acids_Homo sapiens_hsa012300.80217090
70Purine metabolism_Homo sapiens_hsa002300.78814386
71Chronic myeloid leukemia_Homo sapiens_hsa052200.77596628
72Measles_Homo sapiens_hsa051620.75447574
73Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.74990129
74Focal adhesion_Homo sapiens_hsa045100.74585097
75Renal cell carcinoma_Homo sapiens_hsa052110.74484442
76Endometrial cancer_Homo sapiens_hsa052130.74164317
77Type I diabetes mellitus_Homo sapiens_hsa049400.73484466
78Primary immunodeficiency_Homo sapiens_hsa053400.71066741
79Prostate cancer_Homo sapiens_hsa052150.70115331
80Endocytosis_Homo sapiens_hsa041440.69603968
81Hippo signaling pathway_Homo sapiens_hsa043900.69476384
82Chemokine signaling pathway_Homo sapiens_hsa040620.69043063
83Viral myocarditis_Homo sapiens_hsa054160.65917871
84Prolactin signaling pathway_Homo sapiens_hsa049170.63567119
85Graft-versus-host disease_Homo sapiens_hsa053320.62582639
86Other glycan degradation_Homo sapiens_hsa005110.59695640
87* Sphingolipid signaling pathway_Homo sapiens_hsa040710.59655636
88Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59431818
89Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.59333589
90Selenocompound metabolism_Homo sapiens_hsa004500.59055661
91Acute myeloid leukemia_Homo sapiens_hsa052210.58525235
92Fructose and mannose metabolism_Homo sapiens_hsa000510.57690852
93Thyroid cancer_Homo sapiens_hsa052160.57543241
94Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.57115346
95HIF-1 signaling pathway_Homo sapiens_hsa040660.56960518
96TGF-beta signaling pathway_Homo sapiens_hsa043500.56770590
97* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.56054659
98Glioma_Homo sapiens_hsa052140.55274279
99Allograft rejection_Homo sapiens_hsa053300.53331426
100Basal cell carcinoma_Homo sapiens_hsa052170.52072725
101* Hepatitis B_Homo sapiens_hsa051610.51110688
102Jak-STAT signaling pathway_Homo sapiens_hsa046300.50774230
103Adipocytokine signaling pathway_Homo sapiens_hsa049200.50059277
104Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49961155
105Hematopoietic cell lineage_Homo sapiens_hsa046400.48205551
106NOD-like receptor signaling pathway_Homo sapiens_hsa046210.46981085
107African trypanosomiasis_Homo sapiens_hsa051430.46755801
108Influenza A_Homo sapiens_hsa051640.45806684
109Leukocyte transendothelial migration_Homo sapiens_hsa046700.45351001
110Lysosome_Homo sapiens_hsa041420.45125398
111Proteoglycans in cancer_Homo sapiens_hsa052050.44982348
112Glycosaminoglycan degradation_Homo sapiens_hsa005310.44938695
113Cysteine and methionine metabolism_Homo sapiens_hsa002700.44386830
114mTOR signaling pathway_Homo sapiens_hsa041500.44363772
115RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.44185031
116Central carbon metabolism in cancer_Homo sapiens_hsa052300.43666542
117Adherens junction_Homo sapiens_hsa045200.42935481
118Salmonella infection_Homo sapiens_hsa051320.42642019
119Asthma_Homo sapiens_hsa053100.42041245
120Cyanoamino acid metabolism_Homo sapiens_hsa004600.41676434
121Glutathione metabolism_Homo sapiens_hsa004800.41286093
122Intestinal immune network for IgA production_Homo sapiens_hsa046720.40197239
123Malaria_Homo sapiens_hsa051440.39517146
124Drug metabolism - other enzymes_Homo sapiens_hsa009830.38159569
125Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37789581
126* Colorectal cancer_Homo sapiens_hsa052100.37783585
127* Pathways in cancer_Homo sapiens_hsa052000.37444673
128TNF signaling pathway_Homo sapiens_hsa046680.37168885
129Galactose metabolism_Homo sapiens_hsa000520.35443710
130Regulation of actin cytoskeleton_Homo sapiens_hsa048100.35018637
131N-Glycan biosynthesis_Homo sapiens_hsa005100.34505763
132Oocyte meiosis_Homo sapiens_hsa041140.33897948
133Hedgehog signaling pathway_Homo sapiens_hsa043400.33764329
134Phagosome_Homo sapiens_hsa041450.32404500
135Toxoplasmosis_Homo sapiens_hsa051450.31879423
136Pertussis_Homo sapiens_hsa051330.31232084
137Protein export_Homo sapiens_hsa030600.31078362
138Melanoma_Homo sapiens_hsa052180.30665436

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