BATF3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the basic leucine zipper protein family. The encoded protein functions as a transcriptional repressor when heterodimerizing with JUN. The protein may play a role in repression of interleukin-2 and matrix metalloproteinase-1 transcription. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)5.66810778
2NIK/NF-kappaB signaling (GO:0038061)5.53523373
3regulation of vitamin D biosynthetic process (GO:0060556)5.44275693
4regulation of dendritic cell antigen processing and presentation (GO:0002604)5.34452695
5regulation of chronic inflammatory response (GO:0002676)5.24053940
6regulation of T-helper 1 cell differentiation (GO:0045625)5.15064871
7neutrophil activation (GO:0042119)4.91348462
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.87566739
9positive regulation of antigen processing and presentation (GO:0002579)4.82818116
10granulocyte activation (GO:0036230)4.73923598
11cellular response to exogenous dsRNA (GO:0071360)4.71874620
12antigen processing and presentation of endogenous antigen (GO:0019883)4.61826897
13regulation of activation of Janus kinase activity (GO:0010533)4.58572708
14negative regulation of interleukin-12 production (GO:0032695)4.49490637
15positive regulation of interferon-alpha production (GO:0032727)4.46117119
16positive regulation of interleukin-12 production (GO:0032735)4.44172293
17regulation of RIG-I signaling pathway (GO:0039535)4.41422951
18response to muramyl dipeptide (GO:0032495)4.23100170
19regulation of immunoglobulin secretion (GO:0051023)4.22818928
20regulation of vitamin metabolic process (GO:0030656)4.18603344
21regulation of interferon-alpha production (GO:0032647)4.17860163
22* myeloid dendritic cell differentiation (GO:0043011)4.17145496
23regulation of antigen processing and presentation (GO:0002577)4.12225241
24natural killer cell mediated cytotoxicity (GO:0042267)4.07616307
25natural killer cell mediated immunity (GO:0002228)4.07616307
26immunoglobulin mediated immune response (GO:0016064)4.03122974
27regulation of interleukin-12 biosynthetic process (GO:0045075)4.01157867
28regulation of interleukin-2 biosynthetic process (GO:0045076)3.95498501
29cellular response to interferon-beta (GO:0035458)3.90994373
30positive regulation of natural killer cell differentiation (GO:0032825)3.90780308
31response to protozoan (GO:0001562)3.88041572
32* myeloid dendritic cell activation (GO:0001773)3.87821097
33positive regulation of T-helper cell differentiation (GO:0045624)3.86707406
34interferon-gamma-mediated signaling pathway (GO:0060333)3.86043421
35positive regulation of monocyte chemotaxis (GO:0090026)3.84951933
36regulation of hypersensitivity (GO:0002883)3.83942048
37positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.81496839
38regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.78586277
39regulation of cytokine secretion involved in immune response (GO:0002739)3.74156492
40positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.73569620
41positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.71928228
42positive regulation of T-helper 1 type immune response (GO:0002827)3.69537881
43cellular response to type I interferon (GO:0071357)3.68816803
44type I interferon signaling pathway (GO:0060337)3.68816803
45regulation of inflammatory response to antigenic stimulus (GO:0002861)3.67592520
46cellular response to zinc ion (GO:0071294)3.67381750
47regulation of interferon-beta biosynthetic process (GO:0045357)3.65823576
48antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.65515239
49antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.65515239
50growth hormone receptor signaling pathway (GO:0060396)3.64504277
51monocyte chemotaxis (GO:0002548)3.63724298
52response to type I interferon (GO:0034340)3.62679547
53regulation of T-helper 1 type immune response (GO:0002825)3.53656110
54negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.52073545
55response to peptidoglycan (GO:0032494)3.48918161
56T-helper 1 type immune response (GO:0042088)3.48775070
57* dendritic cell differentiation (GO:0097028)3.48569441
58regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.44905913
59positive regulation of type 2 immune response (GO:0002830)3.43806389
60modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.43526070
61modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.43526070
62positive regulation by organism of defense response of other organism involved in symbiotic interact3.43526070
63modulation by symbiont of host immune response (GO:0052553)3.43526070
64positive regulation by symbiont of host defense response (GO:0052509)3.43526070
65modulation by symbiont of host defense response (GO:0052031)3.43526070
66positive regulation of chemokine biosynthetic process (GO:0045080)3.43235482
67regulation of interleukin-12 production (GO:0032655)3.41327683
68positive regulation of defense response to virus by host (GO:0002230)3.40498756
69positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.39852935
70positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.39850099
71lipopolysaccharide-mediated signaling pathway (GO:0031663)3.37853348
72regulation of T-helper 2 cell differentiation (GO:0045628)3.36877338
73respiratory burst (GO:0045730)3.36762282
74positive regulation of immunoglobulin mediated immune response (GO:0002891)3.36374199
75positive regulation of B cell mediated immunity (GO:0002714)3.36374199
76positive regulation of interleukin-2 production (GO:0032743)3.35803368
77positive regulation of alpha-beta T cell proliferation (GO:0046641)3.35736195
78regulation of podosome assembly (GO:0071801)3.35394542
79regulation of alpha-beta T cell proliferation (GO:0046640)3.32607396
80positive regulation of gamma-delta T cell activation (GO:0046645)3.32062304
81Arp2/3 complex-mediated actin nucleation (GO:0034314)3.29032005
82negative thymic T cell selection (GO:0045060)3.26644492
83regulation of T-helper cell differentiation (GO:0045622)3.25163212
84dendritic cell chemotaxis (GO:0002407)3.22803822
85sequestering of actin monomers (GO:0042989)3.22651097
86regulation of type I interferon-mediated signaling pathway (GO:0060338)3.22222178
87macrophage activation involved in immune response (GO:0002281)3.21237349
88regulation of interleukin-8 biosynthetic process (GO:0045414)3.20909805
89negative regulation of viral genome replication (GO:0045071)3.18448979
90positive regulation of interferon-beta production (GO:0032728)3.17335614
91CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.17321767
92dendritic cell migration (GO:0036336)3.16945104
93regulation of chemokine biosynthetic process (GO:0045073)3.12743645
94B cell mediated immunity (GO:0019724)3.11792132
95negative regulation of cytokine production involved in immune response (GO:0002719)3.11594018
96leukocyte mediated cytotoxicity (GO:0001909)3.11409204
97positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.10805729
98positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.10470396
99regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.08682302
100positive regulation of interferon-gamma production (GO:0032729)3.08675520
101cellular response to growth hormone stimulus (GO:0071378)3.07901932
102regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.06006695
103positive regulation of humoral immune response (GO:0002922)3.05299955
104response to interferon-beta (GO:0035456)3.03709452
105negative T cell selection (GO:0043383)3.03575588
106cytokine secretion (GO:0050663)3.03147560
107cellular response to interferon-gamma (GO:0071346)3.01698193
108positive regulation of cellular amide metabolic process (GO:0034250)2.99981661
109T cell migration (GO:0072678)2.99292719
110natural killer cell differentiation (GO:0001779)2.98459418
111negative regulation of growth of symbiont in host (GO:0044130)2.97333596
112negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.97333596
113modulation of growth of symbiont involved in interaction with host (GO:0044144)2.97333596
114regulation of growth of symbiont in host (GO:0044126)2.97333596
115lymphocyte mediated immunity (GO:0002449)2.95504455
116positive regulation of NF-kappaB import into nucleus (GO:0042346)2.95418813
117* myeloid leukocyte activation (GO:0002274)2.94778763
118regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.94594979
119myeloid cell activation involved in immune response (GO:0002275)2.93846599
120positive regulation of isotype switching (GO:0045830)2.93167596
121response to interferon-gamma (GO:0034341)2.92799390
122regulation of mononuclear cell migration (GO:0071675)2.89654892
123regulation of B cell receptor signaling pathway (GO:0050855)2.89586950
124eosinophil chemotaxis (GO:0048245)2.89306599
125defense response to protozoan (GO:0042832)2.89257989
126positive regulation of cytokine biosynthetic process (GO:0042108)2.85953813
127positive regulation of interleukin-10 production (GO:0032733)2.85863417
128regulation of fever generation (GO:0031620)2.85279646
129positive regulation of lymphocyte apoptotic process (GO:0070230)2.85216286
130natural killer cell activation (GO:0030101)2.84457374
131positive regulation of interleukin-17 production (GO:0032740)2.84364043
132positive regulation of heat generation (GO:0031652)2.84239898
133pinocytosis (GO:0006907)2.83649965
134regulation of response to interferon-gamma (GO:0060330)2.83255467
135regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.82742908
136regulation of T cell tolerance induction (GO:0002664)2.82675556
137production of molecular mediator involved in inflammatory response (GO:0002532)2.81796520
138response to interleukin-15 (GO:0070672)2.81103484
139germinal center formation (GO:0002467)2.79789105
140regulation of interleukin-2 production (GO:0032663)2.77776497
141cellular response to interleukin-15 (GO:0071350)2.76838364
142branching involved in labyrinthine layer morphogenesis (GO:0060670)2.76152016
143negative regulation of myeloid cell apoptotic process (GO:0033033)2.73624374
144regulation of defense response to virus by host (GO:0050691)2.73612347
145JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.71971513
146regulation of interferon-gamma production (GO:0032649)2.71330566
147regulation of isotype switching (GO:0045191)2.71005433
148leukocyte apoptotic process (GO:0071887)2.70677336
149positive regulation of protein homooligomerization (GO:0032464)2.70232895
150T cell differentiation involved in immune response (GO:0002292)2.69671654
151alpha-beta T cell differentiation involved in immune response (GO:0002293)2.69671654
152alpha-beta T cell activation involved in immune response (GO:0002287)2.69671654
153regulation of B cell mediated immunity (GO:0002712)2.69528867
154positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.69475217
155regulation of immunoglobulin mediated immune response (GO:0002889)2.67601045

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.29027419
2IRF8_21731497_ChIP-ChIP_J774_Mouse7.07315835
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.21228753
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.81811476
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.77927791
6* IRF8_27001747_Chip-Seq_BMDM_Mouse4.32069509
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.19955355
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.65021860
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.40819294
10RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.32824164
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.30407097
12STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.23381082
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.11710657
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.94148405
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.94032636
16Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.91113915
17STAT4_19710469_ChIP-ChIP_TH1__Mouse2.89702490
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.86028125
19MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.80526951
20MYB_21317192_ChIP-Seq_ERMYB_Mouse2.69880562
21TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.49903972
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.35727610
23NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.35327840
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.22705548
25VDR_24787735_ChIP-Seq_THP-1_Human2.10136186
26SPI1_23547873_ChIP-Seq_NB4_Human1.98634568
27* MYB_26560356_Chip-Seq_TH2_Human1.96381569
28EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.95715271
29NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.94305966
30BRD4_27068464_Chip-Seq_AML-cells_Mouse1.91731554
31TP63_17297297_ChIP-ChIP_HaCaT_Human1.87871124
32MYC_22102868_ChIP-Seq_BL_Human1.86741477
33SMAD_19615063_ChIP-ChIP_OVARY_Human1.84226155
34RUNX_20019798_ChIP-Seq_JUKART_Human1.84175920
35JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.81139870
36STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.77548957
37* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.77325420
38MAF_26560356_Chip-Seq_TH1_Human1.70757902
39VDR_24763502_ChIP-Seq_THP-1_Human1.66041057
40FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.64850009
41MYC_18555785_ChIP-Seq_MESCs_Mouse1.63098533
42PU_27001747_Chip-Seq_BMDM_Mouse1.62786582
43KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.61857915
44THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.60523840
45VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.57712463
46* MYB_26560356_Chip-Seq_TH1_Human1.51836760
47ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.51493753
48* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.50412724
49ETS1_20019798_ChIP-Seq_JURKAT_Human1.50241070
50SPI1_23127762_ChIP-Seq_K562_Human1.49777074
51TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.44521419
52* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.44328905
53* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.43775211
54MYC_18358816_ChIP-ChIP_MESCs_Mouse1.39841009
55GATA3_27048872_Chip-Seq_THYMUS_Human1.38017986
56CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.38005738
57* RUNX1_22412390_ChIP-Seq_EML_Mouse1.35800907
58HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.33684630
59CREB1_15753290_ChIP-ChIP_HEK293T_Human1.29941965
60VDR_21846776_ChIP-Seq_THP-1_Human1.26771459
61RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.25708796
62SCL_19346495_ChIP-Seq_HPC-7_Human1.24665024
63EGR1_19032775_ChIP-ChIP_M12_Human1.24502572
64* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.24484231
65DCP1A_22483619_ChIP-Seq_HELA_Human1.24461152
66GATA3_26560356_Chip-Seq_TH2_Human1.22500120
67STAT3_1855785_ChIP-Seq_MESCs_Mouse1.20158765
68GABP_17652178_ChIP-ChIP_JURKAT_Human1.17567237
69VDR_23849224_ChIP-Seq_CD4+_Human1.17001525
70* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16577748
71MYC_19030024_ChIP-ChIP_MESCs_Mouse1.16371959
72SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.15044450
73MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.13389659
74GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.11318145
75TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11053409
76TFEB_21752829_ChIP-Seq_HELA_Human1.10066405
77* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.09486433
78SMRT_27268052_Chip-Seq_Bcells_Human1.09224951
79EST1_17652178_ChIP-ChIP_JURKAT_Human1.08450820
80* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08355443
81GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.08204360
82CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.07952818
83FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.06837492
84HOXB4_20404135_ChIP-ChIP_EML_Mouse1.06003109
85LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.05756097
86CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.05674066
87FOXP3_21729870_ChIP-Seq_TREG_Human1.05399851
88E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.04924932
89NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.04127503
90* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03673189
91SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01462505
92TCF7_22412390_ChIP-Seq_EML_Mouse1.00971113
93E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.00876677
94TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00262746
95MAF_26560356_Chip-Seq_TH2_Human0.95801481
96SRY_22984422_ChIP-ChIP_TESTIS_Rat0.95468844
97MYC_19079543_ChIP-ChIP_MESCs_Mouse0.94990218
98THAP11_20581084_ChIP-Seq_MESCs_Mouse0.92167883
99CIITA_25753668_ChIP-Seq_RAJI_Human0.92051422
100LXR_22292898_ChIP-Seq_THP-1_Human0.91691513
101GATA2_22383799_ChIP-Seq_G1ME_Mouse0.90957097
102ZNF263_19887448_ChIP-Seq_K562_Human0.90528626
103* CTCF_26484167_Chip-Seq_Bcells_Mouse0.89958394
104STAT1_20625510_ChIP-Seq_HELA_Human0.87130447
105TRIM28_21343339_ChIP-Seq_HEK293_Human0.86766923
106BCL6_27268052_Chip-Seq_Bcells_Human0.86737790
107GABP_19822575_ChIP-Seq_HepG2_Human0.86222807
108CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.85424039
109E2F1_18555785_ChIP-Seq_MESCs_Mouse0.83095838
110GATA2_21666600_ChIP-Seq_HMVEC_Human0.79900080
111ELK3_25401928_ChIP-Seq_HUVEC_Human0.79622137
112SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.79136736
113SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.79136736
114UTX_26944678_Chip-Seq_JUKART_Human0.77551059
115GATA1_22025678_ChIP-Seq_K562_Human0.75269903
116CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.71665170
117ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.71009439
118LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.70836875
119* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.70780973
120NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.70641290
121NRF2_20460467_ChIP-Seq_MEFs_Mouse0.70641290
122SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.70634903
123* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.70321509
124* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.69777286
125JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.68913806
126CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.68255103
127GATA1_19941827_ChIP-Seq_MEL_Mouse0.66273837
128KDM2B_26808549_Chip-Seq_SUP-B15_Human0.65907740
129CJUN_26792858_Chip-Seq_BT549_Human0.64760032
130SOX2_20726797_ChIP-Seq_SW620_Human0.64320851
131* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.63497657
132TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.60928034
133KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.60703229
134CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.60038656
135* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.59150455
136SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.58786042
137* KDM2B_26808549_Chip-Seq_DND41_Human0.58642488
138FOXO3_23340844_ChIP-Seq_DLD1_Human0.57017869
139NOTCH1_21737748_ChIP-Seq_TLL_Human0.53496646
140KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.52981957
141IKZF1_21737484_ChIP-ChIP_HCT116_Human0.52313920

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0001835_abnormal_antigen_presentation5.73765525
2MP0000685_abnormal_immune_system3.97877839
3MP0002148_abnormal_hypersensitivity_rea3.86332943
4MP0003436_decreased_susceptibility_to3.73780963
5MP0002138_abnormal_hepatobiliary_system3.65996114
6MP0009785_altered_susceptibility_to3.45618951
7MP0004510_myositis3.40539694
8* MP0001790_abnormal_immune_system3.20878446
9* MP0005387_immune_system_phenotype3.20878446
10MP0005000_abnormal_immune_tolerance3.08343743
11MP0005671_abnormal_response_to2.99354587
12MP0002419_abnormal_innate_immunity2.80225277
13* MP0002452_abnormal_antigen_presenting2.70053889
14MP0005025_abnormal_response_to2.66246456
15MP0006082_CNS_inflammation2.64224908
16MP0001800_abnormal_humoral_immune2.63530648
17MP0002723_abnormal_immune_serum2.51198344
18MP0002006_tumorigenesis2.44313106
19MP0002254_reproductive_system_inflammat2.41474011
20MP0002166_altered_tumor_susceptibility2.33544026
21* MP0001819_abnormal_immune_cell2.32662673
22MP0005310_abnormal_salivary_gland2.29926912
23MP0003303_peritoneal_inflammation2.27751335
24* MP0002420_abnormal_adaptive_immunity2.26332472
25MP0002163_abnormal_gland_morphology2.25324005
26MP0001853_heart_inflammation2.16848263
27MP0001348_abnormal_lacrimal_gland2.15730333
28MP0002405_respiratory_system_inflammati1.88465545
29MP0003724_increased_susceptibility_to1.87675289
30MP0001533_abnormal_skeleton_physiology1.85267319
31* MP0000716_abnormal_immune_system1.74790308
32MP0003448_altered_tumor_morphology1.67596569
33MP0009764_decreased_sensitivity_to1.67330482
34MP0002398_abnormal_bone_marrow1.65296064
35MP0001845_abnormal_inflammatory_respons1.63472241
36MP0003806_abnormal_nucleotide_metabolis1.62749996
37MP0009840_abnormal_foam_cell1.62157322
38MP0002877_abnormal_melanocyte_morpholog1.60845067
39MP0009333_abnormal_splenocyte_physiolog1.58108390
40MP0002277_abnormal_respiratory_mucosa1.54804873
41MP0002933_joint_inflammation1.54756741
42MP0010155_abnormal_intestine_physiology1.49649621
43MP0005076_abnormal_cell_differentiation1.45198469
44MP0008469_abnormal_protein_level1.42898096
45MP0004947_skin_inflammation1.41049571
46MP0001346_abnormal_lacrimal_gland1.40251343
47MP0000858_altered_metastatic_potential1.38624888
48MP0005058_abnormal_lysosome_morphology1.37785997
49* MP0002429_abnormal_blood_cell1.35224534
50MP0002332_abnormal_exercise_endurance1.35222214
51MP0005464_abnormal_platelet_physiology1.34973655
52MP0003191_abnormal_cellular_cholesterol1.32539156
53MP0000689_abnormal_spleen_morphology1.24295418
54MP0002009_preneoplasia1.24053780
55MP0002998_abnormal_bone_remodeling1.23724125
56MP0001873_stomach_inflammation1.20733588
57MP0002722_abnormal_immune_system1.20366544
58MP0008260_abnormal_autophagy1.15948462
59MP0008004_abnormal_stomach_pH1.10617197
60MP0000343_altered_response_to1.07646506
61MP0003763_abnormal_thymus_physiology1.07298078
62MP0004782_abnormal_surfactant_physiolog1.06851683
63MP0005379_endocrine/exocrine_gland_phen1.02615963
64MP0003091_abnormal_cell_migration1.01123827
65MP0003075_altered_response_to0.99438383
66MP0005390_skeleton_phenotype0.99410588
67MP0002139_abnormal_hepatobiliary_system0.98855196
68MP0003195_calcinosis0.98572334
69MP0005397_hematopoietic_system_phenotyp0.93906994
70MP0001545_abnormal_hematopoietic_system0.93906994
71MP0003566_abnormal_cell_adhesion0.92679418
72MP0003453_abnormal_keratinocyte_physiol0.91424981
73MP0001881_abnormal_mammary_gland0.89096735
74MP0000569_abnormal_digit_pigmentation0.88029271
75MP0005451_abnormal_body_composition0.83370344
76MP0005166_decreased_susceptibility_to0.82740786
77MP0010307_abnormal_tumor_latency0.82268104
78MP0003186_abnormal_redox_activity0.77220337
79MP0005165_increased_susceptibility_to0.76189925
80MP0003646_muscle_fatigue0.75355386
81MP0009763_increased_sensitivity_to0.74765215
82MP0001986_abnormal_taste_sensitivity0.74157647
83MP0003866_abnormal_defecation0.73585014
84MP0000249_abnormal_blood_vessel0.73233625
85MP0003300_gastrointestinal_ulcer0.71652028
86MP0000703_abnormal_thymus_morphology0.71332363
87MP0009765_abnormal_xenobiotic_induced0.69239557
88MP0003795_abnormal_bone_structure0.66539668
89MP0000767_abnormal_smooth_muscle0.66372644
90MP0008873_increased_physiological_sensi0.64950750
91MP0005381_digestive/alimentary_phenotyp0.63152835
92MP0003705_abnormal_hypodermis_morpholog0.62900169
93MP0005167_abnormal_blood-brain_barrier0.62415404
94MP0003693_abnormal_embryo_hatching0.62034802
95MP0000604_amyloidosis0.60629683
96MP0000627_abnormal_mammary_gland0.60444268
97MP0001849_ear_inflammation0.59266931
98MP0000465_gastrointestinal_hemorrhage0.59002718
99MP0000490_abnormal_crypts_of0.58435530
100MP0004808_abnormal_hematopoietic_stem0.58123406
101MP0005164_abnormal_response_to0.57947071
102MP0002136_abnormal_kidney_physiology0.56980282
103MP0002019_abnormal_tumor_incidence0.56928755
104MP0005084_abnormal_gallbladder_morpholo0.56509145
105MP0006054_spinal_hemorrhage0.54257404
106MP0002876_abnormal_thyroid_physiology0.54015489
107MP0003172_abnormal_lysosome_physiology0.53789376
108MP0010386_abnormal_urinary_bladder0.53620335
109MP0002396_abnormal_hematopoietic_system0.53161446
110MP0002693_abnormal_pancreas_physiology0.52425228
111MP0005647_abnormal_sex_gland0.52095296
112MP0004883_abnormal_blood_vessel0.52091069
113MP0001919_abnormal_reproductive_system0.51810447
114MP0001542_abnormal_bone_strength0.51731772
115MP0000313_abnormal_cell_death0.51521906
116MP0001501_abnormal_sleep_pattern0.51406514
117MP0005266_abnormal_metabolism0.50731290
118MP0001663_abnormal_digestive_system0.50407167
119MP0005319_abnormal_enzyme/_coenzyme0.49219809
120MP0000371_diluted_coat_color0.49149225
121MP0005584_abnormal_enzyme/coenzyme_acti0.48811137
122MP0008874_decreased_physiological_sensi0.48144977
123MP0009278_abnormal_bone_marrow0.47511362
124MP0001243_abnormal_dermal_layer0.46597705
125MP0005174_abnormal_tail_pigmentation0.46438410

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.80958177
2Recurrent bacterial skin infections (HP:0005406)5.53521874
3Recurrent abscess formation (HP:0002722)5.46228025
4Myositis (HP:0100614)4.51953832
5Elevated erythrocyte sedimentation rate (HP:0003565)4.45816485
6Recurrent gram-negative bacterial infections (HP:0005420)4.44626553
7Optic neuritis (HP:0100653)4.22216075
8Retrobulbar optic neuritis (HP:0100654)4.22216075
9Recurrent fungal infections (HP:0002841)4.21124921
10Mediastinal lymphadenopathy (HP:0100721)4.19496035
11Orchitis (HP:0100796)4.12525775
12Epiphyseal dysplasia (HP:0002656)4.07096653
13Recurrent viral infections (HP:0004429)3.87160316
14Abnormality of macrophages (HP:0004311)3.84556858
15Recurrent skin infections (HP:0001581)3.82708842
16IgA deficiency (HP:0002720)3.76242594
17Systemic lupus erythematosus (HP:0002725)3.67172486
18Increased IgM level (HP:0003496)3.62389613
19Irregular epiphyses (HP:0010582)3.56068154
20Recurrent cutaneous fungal infections (HP:0011370)3.55947310
21Chronic mucocutaneous candidiasis (HP:0002728)3.55947310
22Vasculitis (HP:0002633)3.34701430
23Autoimmune hemolytic anemia (HP:0001890)3.34030674
24Abnormal delayed hypersensitivity skin test (HP:0002963)3.13538530
25Gastrointestinal infarctions (HP:0005244)3.10746282
26Basal ganglia calcification (HP:0002135)3.10593873
27Gangrene (HP:0100758)3.10300763
28Pulmonary infiltrates (HP:0002113)3.01045289
29T lymphocytopenia (HP:0005403)2.99922580
30Chronic obstructive pulmonary disease (HP:0006510)2.99885269
31Obstructive lung disease (HP:0006536)2.99885269
32Arterial thrombosis (HP:0004420)2.96653360
33Myocardial infarction (HP:0001658)2.95536483
34Chronic otitis media (HP:0000389)2.94904369
35Autoimmune thrombocytopenia (HP:0001973)2.93823613
36Abnormality of T cells (HP:0002843)2.87983124
37Vitreoretinal degeneration (HP:0000655)2.86830239
38Thrombocytosis (HP:0001894)2.83062601
39Recurrent pneumonia (HP:0006532)2.82254215
40Gingivitis (HP:0000230)2.81278087
41Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.75447139
42Hypergammaglobulinemia (HP:0010702)2.71686651
43Recurrent lower respiratory tract infections (HP:0002783)2.67114493
44Meningitis (HP:0001287)2.64871038
45Hepatosplenomegaly (HP:0001433)2.64747104
46Small epiphyses (HP:0010585)2.63889486
47Vacuolated lymphocytes (HP:0001922)2.63485719
48Periodontitis (HP:0000704)2.62111670
49Increased cerebral lipofuscin (HP:0011813)2.62086721
50Colitis (HP:0002583)2.59016481
51Delayed epiphyseal ossification (HP:0002663)2.58879148
52Keratoconjunctivitis sicca (HP:0001097)2.58797249
53Increased neuronal autofluorescent lipopigment (HP:0002074)2.55392595
54Cellulitis (HP:0100658)2.52814666
55Polyneuropathy (HP:0001271)2.50483257
56Abnormality of the pleura (HP:0002103)2.50172407
57Keratoconjunctivitis (HP:0001096)2.47587066
58Absent rod-and cone-mediated responses on ERG (HP:0007688)2.45844446
59IgG deficiency (HP:0004315)2.45691786
60Chronic diarrhea (HP:0002028)2.45608407
61Abnormal tarsal ossification (HP:0008369)2.44246699
62Interstitial pulmonary disease (HP:0006530)2.41846560
63Increased serum ferritin (HP:0003281)2.41105406
64Hemoptysis (HP:0002105)2.40520773
65Absent frontal sinuses (HP:0002688)2.38991397
66Anorexia (HP:0002039)2.37320092
67Flat capital femoral epiphysis (HP:0003370)2.35938157
68Glomerulonephritis (HP:0000099)2.34737780
69Mutism (HP:0002300)2.32128143
70Parakeratosis (HP:0001036)2.31990997
71Arthralgia (HP:0002829)2.31268375
72Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.30558459
73Peritonitis (HP:0002586)2.29675892
74Increased IgE level (HP:0003212)2.29266849
75Leukocytosis (HP:0001974)2.28240196
76Abnormality of proline metabolism (HP:0010907)2.28215350
77Hydroxyprolinuria (HP:0003080)2.28215350
78Abnormality of glycolipid metabolism (HP:0010969)2.26950536
79Abnormality of liposaccharide metabolism (HP:0010968)2.26950536
80Abnormality of glycosphingolipid metabolism (HP:0004343)2.26950536
81Agammaglobulinemia (HP:0004432)2.25147928
82Porencephaly (HP:0002132)2.24250315
83Gingival bleeding (HP:0000225)2.23889010
84Panhypogammaglobulinemia (HP:0003139)2.22879452
85Keratitis (HP:0000491)2.21862799
86Gastrointestinal stroma tumor (HP:0100723)2.20767591
87Vertebral compression fractures (HP:0002953)2.20644298
88Tetraparesis (HP:0002273)2.20530943
89Lymphopenia (HP:0001888)2.19722336
90Hypertensive crisis (HP:0100735)2.19455236
91Premature loss of primary teeth (HP:0006323)2.17697301
92Encephalitis (HP:0002383)2.17685158
93Inflammation of the large intestine (HP:0002037)2.17644643
94Arthropathy (HP:0003040)2.17398108
95Abnormality of cells of the lymphoid lineage (HP:0012140)2.16867193
96Poor head control (HP:0002421)2.16544721
97Osteomyelitis (HP:0002754)2.14029613
98Axonal loss (HP:0003447)2.12459333
99Osteolytic defects of the hand bones (HP:0009699)2.11755276
100Osteolytic defects of the phalanges of the hand (HP:0009771)2.11755276
101Glomerulopathy (HP:0100820)2.11752650
102Abnormality of T cell number (HP:0011839)2.11147537
103Disinhibition (HP:0000734)2.10560764
104Cupped ribs (HP:0000887)2.09822374
105Abnormality of the pericardium (HP:0001697)2.08148579
106Cortical dysplasia (HP:0002539)2.07439454
107Loss of speech (HP:0002371)2.04708980
108Gastrointestinal inflammation (HP:0004386)2.02992889
109Nasal polyposis (HP:0100582)2.02845857
110Urticaria (HP:0001025)2.02053482
111Anhidrosis (HP:0000970)2.00413986
112Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.99925775
113Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.99407061
114Flat acetabular roof (HP:0003180)1.99247239
115Recurrent bronchitis (HP:0002837)1.98645108
116Petechiae (HP:0000967)1.98189875
117Cheilitis (HP:0100825)1.98032919
118Flat occiput (HP:0005469)1.97147739
119Generalized aminoaciduria (HP:0002909)1.96914244
120Abnormality of T cell physiology (HP:0011840)1.96078365
121Abnormality of the prostate (HP:0008775)1.95415900
122Nephritis (HP:0000123)1.94817428
123Exertional dyspnea (HP:0002875)1.94377880
124Purpura (HP:0000979)1.94174698
125Abnormal foot bone ossification (HP:0010675)1.94117407
126IgM deficiency (HP:0002850)1.92080601
127Stomatitis (HP:0010280)1.91600931
128Abnormality of the lumbar spine (HP:0100712)1.91112724
129Ragged-red muscle fibers (HP:0003200)1.90915385
130Joint swelling (HP:0001386)1.90322888
131Eosinophilia (HP:0001880)1.90305255
132Renal Fanconi syndrome (HP:0001994)1.89698714
133Hypoplastic ischia (HP:0003175)1.89352611
134Abnormality of the fingertips (HP:0001211)1.89309118
135Cleft eyelid (HP:0000625)1.87910076
136Microvesicular hepatic steatosis (HP:0001414)1.87790530
137Amyloidosis (HP:0011034)1.87604591
138Bone pain (HP:0002653)1.87501969
139Abnormality of complement system (HP:0005339)1.87439296
140Abnormality of the endocardium (HP:0004306)1.87179034
141Microretrognathia (HP:0000308)1.86660565
142Increased hepatocellular lipid droplets (HP:0006565)1.86095800
143B lymphocytopenia (HP:0010976)1.85441085
144Enlarged epiphyses (HP:0010580)1.84062810
145Amaurosis fugax (HP:0100576)1.83326143
146Emphysema (HP:0002097)1.83122498
147Skin rash (HP:0000988)1.82995990

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K146.55572651
2TBK13.70866640
3TYK23.57529814
4IKBKB3.57064365
5BLK3.13779496
6JAK32.99440856
7RIPK42.80857494
8CHUK2.64110329
9MAP3K132.60505187
10TAOK22.60294376
11IRAK42.57727930
12IKBKE2.51679568
13JAK12.43873656
14NEK92.37714686
15TAOK32.33274491
16PRPF4B2.32175063
17MAP4K12.10956357
18IRAK32.00545187
19PIM22.00189647
20BMPR21.98126471
21BUB11.95469365
22EPHB11.81900430
23KIT1.72394788
24CSF1R1.61794860
25TXK1.61002785
26MST41.60989035
27STK161.59486424
28PBK1.57844826
29SMG11.41110663
30STK241.37163309
31PIM11.33858569
32SYK1.27439827
33MATK1.23945180
34VRK21.23937549
35EIF2AK21.19064417
36BMX1.18311270
37JAK21.15563082
38FLT31.15409789
39FGFR31.14994972
40ZAP701.13095340
41BTK1.09265783
42FGFR41.07114076
43ABL21.05075880
44CSK1.03928240
45NEK11.01730596
46EPHA31.00578652
47HCK0.99496233
48NUAK10.94418939
49CDC42BPA0.90320542
50ERBB30.88968256
51RPS6KA40.88238092
52MOS0.87964023
53LYN0.84515516
54PKN10.83912747
55LCK0.82661575
56STK30.82132170
57MAPK110.80594357
58TGFBR20.79450170
59MAP3K80.76677542
60EIF2AK30.75876406
61PRKCQ0.75357152
62STK100.74047020
63TEC0.73097098
64IRAK20.71078735
65MAP3K10.70915877
66MAPKAPK20.68216538
67ARAF0.67790290
68DDR20.67720783
69CDK40.67589547
70HIPK20.65823488
71FES0.63740935
72TRPM70.63248257
73MAP3K30.61540792
74NLK0.61398564
75CLK10.59952723
76STK40.59913577
77PTK60.59602098
78DAPK30.59159387
79KDR0.57976875
80ABL10.57272986
81ICK0.57186944
82LRRK20.56659991
83PRKCD0.56371028
84MAP2K60.55998993
85NME20.54656819
86PAK40.50015042
87IRAK10.49833453
88GRK70.49530740
89TAOK10.47515886
90MAP3K50.46003965
91ILK0.45412537
92SRPK10.45212422
93MAP3K100.44800112
94ERN10.44428065
95YES10.43411224
96DYRK30.43265476
97PAK10.42890826
98SCYL20.42881909
99RPS6KA10.42596724
100NME10.42027302
101EGFR0.41792220
102ALK0.41101190
103SIK30.39194784
104TESK10.38368054
105ITK0.38311005
106CDK60.37917269
107RIPK10.36259245
108BRAF0.35240438
109TESK20.35016761
110MAP2K30.34104721
111RPS6KA60.32349864
112TAF10.32306828
113AURKA0.31040459
114TNK20.30936750
115PRKAA20.30072960
116FGR0.29759234
117MAPK40.28823331
118MAP3K120.28374461
119INSR0.28260878
120MARK30.27587461
121PRKG20.27395498
122DAPK10.27128345
123MAP3K110.26931304
124PDK10.26799632
125CSNK2A10.25750591
126RPS6KA50.25653453
127GSK3A0.25587455
128GRK60.24409207
129TRIB30.24220464
130BCR0.24200717
131NEK60.22768508
132PKN20.22384263
133DYRK1B0.20439633
134RET0.19119066
135TLK10.18533221
136ADRBK20.18478801
137IGF1R0.16505515
138AKT10.15739151

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053323.43389696
2Allograft rejection_Homo sapiens_hsa053303.20911216
3Leishmaniasis_Homo sapiens_hsa051403.18561092
4NF-kappa B signaling pathway_Homo sapiens_hsa040643.13385029
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.73732023
6Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.69948674
7Toll-like receptor signaling pathway_Homo sapiens_hsa046202.68795153
8NOD-like receptor signaling pathway_Homo sapiens_hsa046212.65041750
9Osteoclast differentiation_Homo sapiens_hsa043802.48606077
10Measles_Homo sapiens_hsa051622.38755273
11Type I diabetes mellitus_Homo sapiens_hsa049402.13091011
12RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.11615218
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.05836577
14Antigen processing and presentation_Homo sapiens_hsa046122.04988977
15Legionellosis_Homo sapiens_hsa051342.03129621
16Staphylococcus aureus infection_Homo sapiens_hsa051502.02573309
17Autoimmune thyroid disease_Homo sapiens_hsa053202.02147100
18TNF signaling pathway_Homo sapiens_hsa046681.99917991
19Influenza A_Homo sapiens_hsa051641.97638880
20Toxoplasmosis_Homo sapiens_hsa051451.94139579
21Pertussis_Homo sapiens_hsa051331.94008115
22Tuberculosis_Homo sapiens_hsa051521.86944698
23Rheumatoid arthritis_Homo sapiens_hsa053231.82186771
24Herpes simplex infection_Homo sapiens_hsa051681.78454599
25Malaria_Homo sapiens_hsa051441.76657561
26Apoptosis_Homo sapiens_hsa042101.72068452
27Chemokine signaling pathway_Homo sapiens_hsa040621.68014441
28B cell receptor signaling pathway_Homo sapiens_hsa046621.62271491
29Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.60699276
30Jak-STAT signaling pathway_Homo sapiens_hsa046301.59824189
31Salmonella infection_Homo sapiens_hsa051321.56890839
32Shigellosis_Homo sapiens_hsa051311.53678521
33Viral myocarditis_Homo sapiens_hsa054161.53013623
34Primary immunodeficiency_Homo sapiens_hsa053401.48851909
35Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.48542847
36Asthma_Homo sapiens_hsa053101.35625680
37Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.32820627
38Ribosome_Homo sapiens_hsa030101.26145162
39Phagosome_Homo sapiens_hsa041451.21627181
40Lysosome_Homo sapiens_hsa041421.20519913
41Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.17473893
42African trypanosomiasis_Homo sapiens_hsa051431.16828797
43Hepatitis B_Homo sapiens_hsa051611.15164190
44Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.13860325
45Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.12700013
46T cell receptor signaling pathway_Homo sapiens_hsa046601.08125761
47Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.02235800
48Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.97838835
49Hematopoietic cell lineage_Homo sapiens_hsa046400.97683379
50Prolactin signaling pathway_Homo sapiens_hsa049170.97629920
51AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.97457874
52Hepatitis C_Homo sapiens_hsa051600.96272816
53Acute myeloid leukemia_Homo sapiens_hsa052210.90250743
54Epstein-Barr virus infection_Homo sapiens_hsa051690.89355143
55Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.87738624
56Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.83820125
57Other glycan degradation_Homo sapiens_hsa005110.82589156
58RNA polymerase_Homo sapiens_hsa030200.78594854
59Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.78269515
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.74155335
61Leukocyte transendothelial migration_Homo sapiens_hsa046700.73395027
62Prion diseases_Homo sapiens_hsa050200.68571423
63Glycosaminoglycan degradation_Homo sapiens_hsa005310.68306412
64Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68285858
65Pyrimidine metabolism_Homo sapiens_hsa002400.67487725
66Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.65296620
67Pancreatic cancer_Homo sapiens_hsa052120.65139391
68Small cell lung cancer_Homo sapiens_hsa052220.63295857
69Chronic myeloid leukemia_Homo sapiens_hsa052200.63070391
70Proteasome_Homo sapiens_hsa030500.61615031
71Viral carcinogenesis_Homo sapiens_hsa052030.58291856
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.55743818
73Amoebiasis_Homo sapiens_hsa051460.52249043
74Platelet activation_Homo sapiens_hsa046110.51829324
75Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.51749886
76HTLV-I infection_Homo sapiens_hsa051660.51663032
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51118133
78p53 signaling pathway_Homo sapiens_hsa041150.49895218
79HIF-1 signaling pathway_Homo sapiens_hsa040660.46569109
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.45655960
81Folate biosynthesis_Homo sapiens_hsa007900.44717606
82Spliceosome_Homo sapiens_hsa030400.44590389
83Complement and coagulation cascades_Homo sapiens_hsa046100.43174858
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39460418
85Sulfur relay system_Homo sapiens_hsa041220.38893952
86Sulfur metabolism_Homo sapiens_hsa009200.37284263
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37038407
88DNA replication_Homo sapiens_hsa030300.37019479
89Regulation of autophagy_Homo sapiens_hsa041400.36339951
90Regulation of actin cytoskeleton_Homo sapiens_hsa048100.35643757
91Bladder cancer_Homo sapiens_hsa052190.33206886
92Fructose and mannose metabolism_Homo sapiens_hsa000510.30713741
93Oxidative phosphorylation_Homo sapiens_hsa001900.30515662
94MAPK signaling pathway_Homo sapiens_hsa040100.30508409
95VEGF signaling pathway_Homo sapiens_hsa043700.28710494
96Pentose and glucuronate interconversions_Homo sapiens_hsa000400.28508404
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.25434410
98MicroRNAs in cancer_Homo sapiens_hsa052060.23962336
99Dorso-ventral axis formation_Homo sapiens_hsa043200.23308620
100Parkinsons disease_Homo sapiens_hsa050120.22682188
101Endocytosis_Homo sapiens_hsa041440.22198321
102Adherens junction_Homo sapiens_hsa045200.21671323
103Proteoglycans in cancer_Homo sapiens_hsa052050.21485023
104Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.20373614
105Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.19307648
106RNA transport_Homo sapiens_hsa030130.17498434
107Focal adhesion_Homo sapiens_hsa045100.16970331
108FoxO signaling pathway_Homo sapiens_hsa040680.15871978
109Insulin resistance_Homo sapiens_hsa049310.14982123
110Sphingolipid metabolism_Homo sapiens_hsa006000.14711479
111Prostate cancer_Homo sapiens_hsa052150.13579736
112Pathways in cancer_Homo sapiens_hsa052000.11981447
113Protein export_Homo sapiens_hsa030600.11252510
114Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.10976209
115Systemic lupus erythematosus_Homo sapiens_hsa053220.10955198
116Galactose metabolism_Homo sapiens_hsa000520.10398987
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.10242389
118Drug metabolism - other enzymes_Homo sapiens_hsa009830.09158494
119Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.09055797
120Notch signaling pathway_Homo sapiens_hsa043300.08409161
121Type II diabetes mellitus_Homo sapiens_hsa049300.08214887
122Homologous recombination_Homo sapiens_hsa034400.06724143
123ECM-receptor interaction_Homo sapiens_hsa045120.04126026
124Collecting duct acid secretion_Homo sapiens_hsa049660.03376645

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